DOCSLIB.ORG

Technical Data Sheet US Patent 5877254

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Technical Data Sheet US Patent 5877254 Technical Data Sheet US Patent 5877254 DESCRIPTION Two part-polyurethane-based thermal cure coating, provides excellent resistance to fogging, scratching, and chemical attack. Visgard consists of cross-linked hydrophilic polymers that cause condensed moisture to spread invisibly rather than forming droplets that appear as fog. Intended for use on polycar- bonate, acrylics, nylon, PVC, PETG, and certain other clear Substrate Materials plastics without primers, where • Acrylic (PMMA) limited cure time is applicable. • Nylon Formulation appropriate for pan- • Polycarbonate (PC) • PVC & PETG fed reverse roll, Meyer rod and • Certain Other Clear Plastics slot die coating methods. Premium Anti-Fog, Abrasion, and Physical Characteristics Chemical Resistance • Excellent Abrasion, Chemical, Part A Part B Impact & Scratch Resistance Product Applications Appearance Colorless to Pale Clear Solution • Water Washable Anti-Fog Amber • Polycarbonate Sheet & Film Properties Density 0.94 g/cc 1.05 g/cc • Motorcycle Visors & Face Shields • Exceptional Optical Clarity • Protective Goggles & Masks Solids Content 28% 68% • Anti-Reflective (A/R) Compati- (by weight) • Ski Goggles ble Solvents Diacetone N-butylacetate/ Alcohol xylene Designed for roll-to-roll coating, delivers best-in- Cyclohexane BENEFITS class abrasion, chemical, impact, and scratch re- Tertiary butanol 2,4- • Can be stored at room tem- sistances, with exceptional optical clarity. Visgard pentanedione perature N-methyl scratch resistance is equal to many commercial ant- pyrrolidone • Streamlines manufacturing, fog scratch finishes. Anti-fog properties are retained enhancing yields and profita- Viscosity 8 — 25 cps 200 — 500 cps after repeated washings and years of use. Many (Brookfield) bility. other anti-fog coatings lose their active ingredient or become saturated and fail after only brief expo- sure to water. 1/4 Abrasion Chemical & Scratch Resistant Anti-fog Coating Mixing Ratio Suggested Starting Formulations Mix 10 parts A to 4 parts B, by weight (2.8:1 by TRANSPORTATION & volume) ad mix at low speed until homogene- IN-TRANSIT PRODUCT ous. Be sure all compoentns are fully dissolved. Visgard Part A 100 parts CONDITIONS Aloow to stand long enough for all bubbles to Product can be stored in Visgard Part B 40 parts break. ambient conditions during Tertiary Butyl Alcohol 28 parts shipment from FSICT to the This will give clear solution with a low viscosity customer’s site. of 15-20 cps (12-14 sec. Ford 4) containing 40% Diacetone Alcohol 42 parts solids. The coating formulation works best if it STORAGE CONDITIONS Solids Content 27% is deiluted to 27% solids with a mixture of 75% When stored in a cool dry tertiary butanol (TBA) and 25% diacetone alco- place, Part A will last for one Viscosity 16 cps hol (DAA). Recommended dry coating thickness (1) year, Part B for six (6) ranges frin 0.4 to 0.5 miles (10 to 15 microns), months from the date of Filtration with the thicker coatings providing the best manufacturing. Solutions should be filtered through a 0.2 mi- properties. cron filter cartridge for several hours before coating operations begin and continuously PRODUCT SHIPPING & Caution throughout the coating process. When opera- AVAILABILITY Silicone hard coatings are incompatible with tions stop, drain Visgard from system and Typical lead-time for ship- Visgard and will impair anti-fog performance store at 41-50°F (5-10°C) in a sealed container. ment of Visgard 106-94L is even at low concentrations. Be sure all equip- Circulate DAA through system and drain before four (4) weeks from confirma- ment is thoroughly clean and free from other replacing with Visgard if shut-down will extend tion of a purchase order. coating residues before evaluating Visgard in more than 24 hrs. If shutdown will be over- FSICT provides several ship- production systems. night only, continue pumping but do not allow ping options. Please contact A peristatic pump is best for initial tests be- Visgard to flow in contact with atmosphere. Do an FSICT representative to cause there is no actual contact of Visgard not allow Visgard to stand in a warm pump determine which option best with the pump chamber or mechanical parts. chamber as this may cause gelation. fits your needs. All orders are Circulating diacetone alcohol through the shipped F.O.B. Additional pump, hoses and filter is a good way to re- Pot Life shipment charges including move possible contaminants before start-up IMPORTANT NOTE: The pot life of Visgard customs clearance and fees (if or change over. solutions depends on the environment, spe- applicable) are the responsi- cifically the level of humidity in mixing and bility of the customer. Pure TBA is a solid of 75°F (24°C) and can be application areas. At 22°C (72°F) and 35% handled more easily by adding 10% DAA. This relative humidity (RH), the pot life will range will liquefy solid material and will prevent it from 36 to 48 hours. Adding freshly mixed solu- from solidifying at temperatures as low as 32°F tion to “old” materials extends the working life. (0°C). Do not use normal butyl alcohol, isobu- tyl alcohol or secondary butyl alcohol. Do not Caution: When the pot life of mixed solutions add water, alcohols (other than those recom- has been reached, the material will thicken and mended), glycol ethers, or other compounds gel. This can be stopped by adding a mixture that are reactive toward isocyanates. of methanol and toluene (1:1) when the solu- tion viscosity becomes noticeably high. Avoid The coating composition will tolerate small using Visgard where humidity is 70% or higher. amounts of aliphatic and aromatic hydrocar- Under these conditions the pot life may be as bons, as well as simple ketones and esters. short as 12 hours and gels may limit usefulness. However, these solvents may affect wetting If Visgard solutions are chilled, be sure that behavior and may attack sensitive plastics. humidity in the coating area is low enough to Solvents that contain moisture will cause gela- prevent moisture condensation in and around tion. If solvent-soluble dyes are to be added, it tanks, coated rollers and film substrates. is important to first evaluate color stability plus the effect on pot life and final coating proper- ties 2/4 Abrasion Chemical & Scratch Resistant Anti-fog Coating Clean-Up Shelf Life Wash equipment with Isopropanol, diacetone alcohol HEALTH & SAFETY The unmixed components of Part A remains stable for one year, and the Part B for six or methyl ethyl ketone before the coating cures. INFORMATION Fully cured coatings may be difficult to remove. Add months. Do not use if either material contains Before using this product, 10% isopropyl or alcohol to any leftover Visgard to read and understand the lumps or insoluble precipitate. Do not open prevent gelation so waste can be properly disposed. Safety Data Sheet, SDS, which containers in a humid area. Store in a cool, dry place, away from sources of ignition. provides information on TECHNICAL MEMO health, physical, and environ- VSIGARD PERFORMANCE PROPERTIES mental hazards, handling Applications & Cure Requirements precautions and first aid rec- Cure requirements range from about 30 sec- Clarity ommendations. For a copy of onds at 300°F (150°C) to 2 min. or more at 220° Visgard coatings are exceptionally clear. While an SDS, contact an FSICT F (104°C0. After curing, the coating will feel the specification limit is 1% haze, actual values sales or customer service rubbery and it will take an impression from any are usually less than 0.5%. Often the coating representative. uneven surface it contacts. For this reason it is will fill in fine scratches and actually improve important to laminate a hard, smooth and the clarity of molded parts. WARRANTY & LIABILITY glossing masking before winding. High gloss LIMITATIONS oriented polyester film (PET) or polyethylene- Scratch Resistance This document does not polyester co extruded film such as Scapa Tables Rubbing lightly with #0000 steel wool will constitute any warranty or 1/2 laminating film #26/D8 is recommended. leave only a few light scratches on the Visgard representation regarding Oriented polypropylene film may affect anti- surface. Occasionally, fine scratches will appear FSICT’s product. Please refer fog properties. Adhesive backed or co-extruded but will heal when warmed slightly or when to FISCT Coating Technologies polyethylene masking films are also not recom- moistened, or after simply standing at room Standard Terms and Condi- mended. Any masking other than those recom- temperature for 15 to 30 minutes. Pencil hard- tions or to your purchase mended may be thoroughly tested before com- ness is 8H (on acrylic). agreement with FSICT for the mercial use. warranty coverage of FSICT’s The following data were obtained using a Taber product. Substrates abraser with CS10F wheel and 500g load, ac- The preferred substrates are polycarbonate cording to ASTM D1044: and biaxial oriented polyester films. Excellent wetting flow and adhesion are usually obtained TRADEMARKS 100 Cycles 500 Cycles Fantastik® is a registered trademark without the use of primers or additives. Acryl- of S. C. Johnson & Son, Inc. ics, PVC, PETG, cellulosics, metalized plastics, Uncoated 28%（approx.) 86%（approx.) and some nylons also be coated without pri- Polycarbonate ∆ haze ∆ haze Formula 409® is a registered trade- mers. PVC and cellulosic plastics may contain (PC) mark of The Clorox Company. plasticizers than ca be extracted by the sol- Visgard coated 5.6% ∆ haze 25.5% ∆ haze Lexan® is a registered trademark of vents in Visgard and may be problematic. PC, 15 microns the SABIC. If a substrate cannot tolerate sufficient heat to Visgard coated 7.6% ∆ haze 43.3% ∆ haze Scotch Brite® is a registered trade- cure Visgard, then masking films may not re- PC, 8 microns mark of the 3M Corporation. move cleanly, or may leave haze or spots.
Load more

Recommended publications
  • Alcohols Combined 1405
    ALCOHOLS COMBINED 1405 Formulas: Table 1 MW: Table 1 CAS: Table 2 RTECS: Table 2 METHOD: 1405, Issue 1 EVALUATION: PARTIAL Issue 1: 15 March 2003 OSHA : Table 2 PROPERTIES: Table 1 NIOSH: Table 2 ACGIH: Table 2 COMPOUNDS: (1) n-butyl alcohol (4) n-propyl alcohol (7) cyclohexanol (2) sec-butyl alcohol (5) allyl alcohol (8) isoamyl alcohol (3) isobutyl alcohol (6) diacetone alcohol (9) methyl isobutyl carbinol SYNONYMS: See Table 3. SAMPLING MEASUREMENT SAMPLER: SOLID SORBENT TUBE TECHNIQUE: GAS CHROMATOGRAPHY, FID (Coconut shell charcoal, 100 mg/50 mg) ANALYTE: Compounds above FLOW RATE: 0.01 to 0.2 L/min DESORPTION: 1 mL 5% 2-propanol in CS2 Compounds: (1-3 ) (4-9) VOL-MIN: 2 L 1 L INJECTION -MAX: 10 L 10 L VOLUME: 1 µL SHIPMENT: Routine TEMPERATURE -INJECTION: 220 °C SAMPLE -DETECTOR: 250 - 300 °C STABILITY: See Evaluation of Method. -COLUMN: 35 °C (7 minutes), to 60 °C at 5 °C/minute, hold 5 minutes, up to BLANKS: 2 to 10 field blanks per set 120 °C at 10 °C /minute, hold 3 minutes. CARRIER GAS: He, 4 mL/min ACCURACY COLUMN: Capillary, fused silica, 30 m x 0.32-mm RANGE STUDIED: Not studied [1, 2]. ID; 0.5 µm film polyethylene glycol, DB- wax or equivalent BIAS: Not determined CALIBRATION: Solutions of analyte in eluent (internal OVERALL standard optional) PRECISION (Ö ): Not determined rT RANGE: See EVALUATION OF METHOD. ACCURACY: Not determined ESTIMATED LOD: 1 µg each analyte per sample PRECISION: See EVALUATION OF METHOD. APPLICABILITY: This method may be used to determine two or more of the specified analytes simultaneously.
    [Show full text]
  • Supporting Information
    Supporting Information Section 1 Components of DCM based coating strippers Table 1. Composition of Klean Strip Premium. CAS # Components Concentration 75-09-2 Dichloromethane 70.0-95.0% 67-56-1 Methanol < 5.0% 127087-87-0 Poly(oxy-1,2-ethandiyl) < 5.0% 124-38-9 Carbon dioxide < 5.0% Table 2. Composition of Klean Strip X. CAS # Components Concentration 75-09-2 Dichloromethane 30.0 – 40.0% 67-56-1 Methanol 15.0 – 26.0% 67-64-1 Acetone < 10.0% 1330-20-7 Xylene < 10.0% 108-88-3 Toluene < 10.0% 100-41-4 Ethylbenzene < 5.0% 64-17-5 Ethyl alcohol < 5.0% 67-63-0 Isopropyl alcohol < 5.0% Section 2 Sample preparation for the dwell time test As Figure S1 shows, a gasket was pasted on the conformal coating surface and a sheet of parafilm attached to the back of the printed circuit board to avoid solvent leakage dur- ing the dwell test. Figure 1. Sample preparation for the dwell time test. Section 3 Thickness measurement of coated PCBs Materials and Equipment Printed circuit boards (PCB), acrylic conformal coating, tape, Dektak stylus profiler (Bruker, Arizona, USA). Methods A piece of tape was attached on a PCB before coating. The coating was applied on the PCB using the same method as dip coating in the dwell time test. The PCB was sta- tioned and dried at room temperature for over 24 hours. The tape was then torn out to create a coating step. The PCB was fixed on the detection table using tapes. The stylus scanned from sub- strate to coated area.
    [Show full text]
  • Silfort* SHC1200 Silfort* SHC1200
    Technical Data Sheet SilFORT* SHC1200 SilFORT* SHC1200 Description SilFORT SHC1200 Hard Coat SHC1200 hard coat has been found to yield a clear mar-resistant film when applied to a suitably prepared plastic substrate. It can be applied by flow, dip or spray coating. SilFORT SHP401 Primer SHP401 air-dried primer is used as an adhesion promoter for SHC1200 hard coat on polycarbonate resin. It can be applied by flow, dip or spray coating. Key Features and Benefits Fast cure Abrasion resistance Scratch resistance Good clarity Solvent/chemical resistance SHP401 Primer No thermal cure required Improves coating adhesion Improves water resistance Page 1 of 6 *SilFORT ist ein Markenname der Momentive Performance Materials Inc. SilFORT* SHC1200 Improves ultraviolet resistance SHP401 Primer/SHC1200 Hard Coat on polycarbonate (2 - 4 micron Topcoat Thickness) Cured Film Properties Film Thickness, slow dip coat, 10-18 cm/min 2 – 4 micron withdrawal,18-20% solids at 22C Taber Abrasion, 500 cycles 500G on primed < 6.0 % Haze measured per polycarbonate (CS10F wheel) ASTM D1003. * Index of Refraction 1.4 *Humidity during coating and testing will affect final values. Typical Physical Properties Property SHC1200 Hard Coat SHP401 Primer Solids Content, % 20 ± 1 2.1 ± 0.2 Methanol, Isobutanol, 1-Methoxy-2-propanol, Diacetone Solvent Isopropanol Alcohol Flash Point, PMCC 19.4C 36.1C Density, g/cm3 0.911 0.959 pH 7.3 ± 0.2 - Viscosity, cstk @ 25°C 20 ± 3 4 - 7 Dry Film Thickness, 2.75 - 4.5 0.5 micron VOC, g/l 710 937 Patent Status Nothing contained herein shall be construed to imply the nonexistence of any relevant patents or to constitute the permission, inducement or recommendation to practice any invention covered by any patent, without authority from the owner of the patent.
    [Show full text]
  • Methanol and Acetone Is in Organic Synthesis
    Honeywell Burdick & Jackson® Characterization and Evaluation of Technical Grade Solvents and Comparison to their Purified Counterparts S. Lorenz, M. Bosma, A. Kemperman, V. Mohan and J. Przybytek Abstract: Technical grade solvents and their purified counterparts are separately useful for many different applications. One important application for the common solvents acetonitrile, methanol and acetone is in organic synthesis. Another important application for acetonitrile and methanol is as a diluent or mobile phase in chemical analysis, ie: UV-VIS spectroscopy, HPLC and LC-MS. We have observed and identified a number of impurities in these solvents that may interfere with synthesis and/or accurate analytical testing. For instance, a common contaminant in acetonitrile is acrylonitrile. Trace aldehydes and ketones can be found in methanol. Diacetone alcohol is commonly found in acetone. We have characterized impurity levels in commonly used solvents and will show the variability present in technical grade and purified solvents, using GC, GC-MS and LC-MS. Results on the impurities and their probable effect on synthesis and analytical testing will be presented. METHANOL HPLC Comparison of Methanol Grades HPLC Trace using HPLC Trace using HPLC Method Technical Grade Methanol Purified Methanol 0.200 0.200 Time % % 0.190 0.190 0.180 0.180 (min) Water Methanol 0.170 0.170 0.160 0.160 0.150 0.150 0 95 5 0.140 AU) 0.140 AU) ( ( 0.130 0.130 e e 20 0 100 c 0.120 c 0.120 n 0.110 n 0.110 a a b 0.100 b 0.100 r r 25 0 100 o 0.090 o 0.090 s s 0.080 0.080
    [Show full text]
  • US EPA, Inert (Other) Pesticide Ingredients in Pesticide Products
    Inert Ingredients ordered by CAS Number Updated August 2004 CAS PREFIX NAME List No. 50-21-5 Lactic acid 4B 50-70-4 Sorbitol 4A 50-81-7 L- Ascorbic acid 4A 50-99-7 Dextrose 4A 51-03-6 Piperonyl butoxide 3 51-05-8 Procaine hydrochloride 3 51-55-8 Atropine 3 52-51-7 2- Bromo-2-nitro-propane-1,3-dio 3 54-21-7 Sodium salicylate 3 56-81-5 Glycerol (glycerin) 1,2,3 propanetriol 4A 56-86-0 L- Glutamic acid 3 56-95-1 Chlorhexidine diacetate 3 57-10-3 Hexadecanoic acid 4A 57-11-4 Stearic acid 4A 57-13-6 Urea 4A 57-48-7 D- Fructose 4B 57-50-1 Sugar 4A 57-55-6 Propylene glycol 4B 57-88-5 (3.beta.)- Cholest-5-en-3-ol 4B 58-08-2 1H- Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- 4B 58-56-0 Thiamine mononitrate 4B 58-85-5 Biotin 3 58-86-6 D- Xylose 4B 58-95-7 Vitamin E acetate 3 59-30-3 Folic acid 4B 59-40-5 N-(2- Quinoxalinyl)sulfanilide 3 59-67-6 Nicotinic acid 3 60-00-4 Ethylenediaminetetraacetic acid (EDTA) 4B 60-12-8 Benzeneethanol 3 60-29-7 Ethane, 1,1'-oxybis- 3 60-33-3 Linoleic acid 3 61-73-4 C.I. Basic Blue 9 3 62-33-9 Ethylenediaminetetraacetic acid (EDTA), calcium4B 62-54-4 Acetic acid, calcium salt 4A 63-42-3 D-(+)-Lactose 4A 63-68-3 L- Methionine 4B 64-02-8 Ethylenediaminetetraacetic acid (EDTA), tetraso4B 64-17-5 Ethanol 4B 64-18-6 Formic acid 3 64-19-7 Acetic acid 4B 64-86-8 Colchicine 3 65-85-0 Benzoic acid 4B 66-71-7 1,10- Phenanthroline 3 67-03-8 Thiamin hydrochloride 3 67-43-6 1,1,4,7,7- Diethylenetriaminepentaacetic acid 3 67-48-1 Choline chloride 4B 67-56-1 Methyl alcohol 3 67-63-0 2- Propanol 4B 67-64-1 Acetone 3 67-68-5 Dimethyl
    [Show full text]
  • Safety Assessment of Diacetone Alcohol As Used in Cosmetics
    Safety Assessment of Diacetone Alcohol as Used in Cosmetics Status: Draft Tentative Report for Panel Review Release Date: February 16, 2021 Panel Meeting Date: March 11 – 12, 2021 The Expert Panel for Cosmetic Ingredient Safety members are: Chair, Wilma F. Bergfeld, M.D., F.A.C.P.; Donald V. Belsito, M.D.; David E. Cohen, M.D.; Curtis D. Klaassen, Ph.D.; Daniel C. Liebler, Ph.D.; Lisa A. Peterson, Ph.D.; Ronald C. Shank, Ph.D.; Thomas J. Slaga, Ph.D.; and Paul W. Snyder, D.V.M., Ph.D. Previous Panel member involved in this assessment: James G. Marks, Jr., M.D. The Cosmetic Ingredient Review (CIR) Executive Director is Bart Heldreth, Ph.D. This safety assessment was prepared by Priya Cherian, Scientific Analyst/Writer, CIR. © Cosmetic Ingredient Review 1620 L Street, NW, Suite 1200 ♢ Washington, DC 20036-4702 ♢ ph 202.331.0651 ♢ fax 202.331.0088 ♢ [email protected] Distributed for Comment Only -- Do Not Cite or Quote Commitment & Credibility since 1976 Memorandum To: Expert Panel for Cosmetic Ingredient Safety Members and Liaisons From: Priya Cherian, Scientific Analyst/Writer, CIR Date: February 16, 2021 Subject: Safety Assessment of Diacetone Alcohol as Used in Cosmetics Enclosed is the Draft Tentative Report of the Safety Assessment of Diacetone Alcohol as Used in Cosmetics (diacet032021rep). At the September 2020 meeting, the Expert Panel for Cosmetic Ingredient Review Safety (Panel) issued an Insufficient Data Announcement (IDA) for this ingredient. In order to come to a conclusion of safety, the Panel requested impurities data. Since the previous review of this report, no new data have been received.
    [Show full text]
  • Trace Analysis of Mesityl Oxide and Diacetone Alcohol in Pharmaceuticals by Capillary Gas Chromatography with Flame Ionization Detection
    id22818046 pdfMachine by Broadgun Software - a great PDF writer! - a great PDF creator! - http://www.pdfmachine.com http://www.broadgun.com AASeptemnnbeaar 2ll0y0y9ttiiccaall Volume 8 Issue 3 An Indian Journal Trade Science Inc. CCHHEEMMIISSTTRRYY Full Paper ACAIJ, 8(3) 2009 [346-349] Trace analysis of mesityl oxide and diacetone alcohol in pharmaceuticals by capillary gas chromatography with flame ionization detection K.Rama Seshaiah*1,2, V.Krishna Reddy1, Ch.Krishnaiah1, VVNKV Prasadaraju1, K.Mukkanti2, V.Ranga Reddy1 ’ 1Dr.Reddy s Laboratories Ltd. Active pharmaceutical ingredients, IPDO, Bachupally, Hyderabad-500072, A.P, (INDIA) 2Department of chemisty, J.N.T.University, Kukatpally, Hyderabad-500072, A.P, (INDIA) E-mail: [email protected] Received: 26th May, 2009 ; Accepted: 5th June, 2009 ABSTRACT KEYWORDS A capillary gas chromatographic method using flame ionization detection Pharmaceutical analysis; was developed and validated for the trace analysis (ppm level) of mesityl Mesityl oxide and Diacetone oxide and diacetone alcohol in pharmaceutical drug substance. The method alcohol. utilizes a megabore capillary column with bonded and crosslinked polyeth- ylene glycol stationary phase. A dissolve-and-injection approach was adopted for sample introduction in a split mode (1:1). Water is used as ppm and limit of sample solvent. A limit of detection of about 1.5 and 2 ppm were achieved for the Mesityl oxide and quantitation of about 6 and 10 Diacetone alcohol in drug substance samples. The method optimization and validation are also discussed in this paper. 2009 Trade Science Inc. - INDIA INTRODUCTION ods that are sensitive enough and meet all the regula- tory requirements. Recently, the potential health hazards of trace The pure mesityl oxide and diacetone alcohol are amounts of mesityl oxide and diacetone alcohol in phar- liquids at ambient temperature with a boiling point °C and 170°C respectively.
    [Show full text]
  • Final Report of the Addendum to The
    International Journal of Toxicology, 27(Suppl. 2f53—69, 2008 Copyright © American College of Toxicology ISSN: 1091-5818 print! 1092-874X online 001: 10.1080/10915810802244504 Final Report of the Addendum to the Safety Assessment of n-Butyl Alcohol as Used in Cosmetics’ n-Butyl Alcohol is a primary aliphatic alcohol historically used in care cosmetic products, but new concentration as a solvent nail INTRODUCTION of use data indicate that it also is being used at low concentrations in eye makeup, personal hygiene, and shaving cosmetic products. The Cosmetic Ingredient Review (CIR) evaluated the safety it-Butyl Alcohol has been generally recognized as safe for use as a of n-Butyl Alcohol (n-BuOH) in 1987, finding it safe in the flavoring substance in food and appears on the 1982 Food and Drug practices of use and concentration in nail products (Elder 1987). list of inactive ingredients for approved pre Administration (FDA) This original safety assessment was specific in that the conclu scription drug products. n-Butyl Alcohol can be absorbed through regards the use of n-Butyl Alcohol in the skin, tangs, and gastrointestinal tract. n-Butyl Alcohol may be sion was issued only as formed by hydrolysis of butyl acetate in the blood, but is rapidly nail products. oxidized. The single oral dose ED50 of n-Butyl Alcohol for rats was Recently, CIR undertook a re-review of this ingredient to de 0.79 to 4.36 g/kg. The dermal ED50 for rabbits was 4.2 g/kg. Inhala termine what additional data relevant to the safety of n-Butyl Al humans demonstrate sensory irritation of tion toxicity studies in 3.
    [Show full text]
  • These Two Workbooks Are Provided by As a Convenient Introduc
    These two workbooks are provided by www.hansen-solubility.com as a convenient introduc They are Copyright © 2013 Prof Steven Abbott If you find bugs/issues or would like extra functionality, please email Steven Abbott [email protected] ction to some of the basic HSP methods HSP Sphere dD dP dH R Good 11 18.4 9.7 8.0 7.1 Bad 11 Test Value 16 7 8 Total 22 Delta 2.4 11.4 10.4 Distance 5.5 RED 0.77 Solvents dD dP dH MVol Score Distance Acetone 15.5 10.4 7 73.8 1 5.915773 Acetonitrile 15.3 18 6.1 52.9 0 10.52754 n-Amyl Acetate 15.8 3.3 6.1 148 0 n-Amyl Alcohol 15.9 5.9 13.9 108.6 0 Benzene 18.4 0 2 52.9 0 11.38507 Benzyl Alcohol 18.4 6.3 13.7 103.8 0 Benzyl Benzoate 20 5.1 5.2 190.3 0 1-Butanol 16 5.7 15.8 92 0 2-Butanol 15.8 5.7 14.5 92 0 n-Butyl Acetate 15.8 3.7 6.3 132.6 0 t-Butyl Acetate 15 3.7 6 134.8 0 t-Butyl Alcohol 15.2 5.1 14.7 96 0 Butyl Benzoate 18.3 5.6 5.5 178.1 0 Butyl Diglycol Acetate 16 4.1 8.2 208.2 0 Butyl Glycol Acetate 15.3 7.5 6.8 171.2 0 n-Butyl Propionate 15.7 5.5 5.9 149.3 0 Caprolactone (Epsilon) 19.7 15 7.4 110.8 0 Chloroform 17.8 3.1 5.7 80.5 1 7.075453 m-Cresol 18.5 6.5 13.7 105 1 6.563973 Cyclohexane 16.8 0 0.2 108.9 0 12.82752 Cyclohexanol 17.4 4.1 13.5 105.7 0 Cyclohexanone 17.8 8.4 5.1 104.2 0 Di-isoButyl Ketone 16 3.7 4.1 177.4 0 Diacetone Alcohol 15.8 8.2 10.8 124.3 0 Diethyl Ether 14.5 2.9 4.6 104.7 0 10.87429 Diethylene Glycol Monobut 16 7 10.6 170.4 0 Dimethyl Cyclohexane 16.1 0 1.1 140 0 Dimethyl Sulfoxide (DMSO) 18.4 16.4 10.2 71.3 1 7.066692 1,4-Dioxane 17.5 1.8 9 85.7 0 8.160898 1,3-Dioxolane
    [Show full text]
  • The Mechanism and Kinetics of Methyl Isobutyl Ketone Synthesis from Acetone Over Ion-Exchanged Hydroxyapatite ⇑ Christopher R
    Journal of Catalysis 365 (2018) 174–183 Contents lists available at ScienceDirect Journal of Catalysis journal homepage: www.elsevier.com/locate/jcat The mechanism and kinetics of methyl isobutyl ketone synthesis from acetone over ion-exchanged hydroxyapatite ⇑ Christopher R. Ho a,b, Steven Zheng a, Sankaranarayanapillai Shylesh a,b, Alexis T. Bell a,b, a Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720-1462, United States b Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States article info abstract Article history: The synthesis of methyl isobutyl ketone (MIBK) can be carried out by the condensation of acetone in the Received 9 May 2018 presence of hydrogen over a supported metal catalyst. Previous studies have shown that hydroxyapatite Revised 26 June 2018 is an excellent catalyst for condensation reactions. The present investigation was undertaken in order to Accepted 2 July 2018 elucidate the reaction mechanism and site requirements for acetone coupling to MIBK over a physical Available online 18 July 2018 mixture of hydroxyapatite and Pd/SiO2. The reaction is found to proceed by consecutive aldol addition to form diacetone alcohol (DAA), dehydration of DAA to mesityl oxide (MO), and hydrogenation of MO Keywords: to MIBK. The products formed by feeding DAA and MO reveal that aldol addition of acetone is rapid Aldol condensation and reversible, and that the subsequent dehydration of DAA is rate-limiting. Pyridine and CO titration Acid-base strength 2 CAC coupling show that aldol dehydration occurs over basic sites via an E1cB mechanism. A series of cation- Green chemistry substituted hydroxyapatite samples were prepared by ion-exchange to further investigate the role of acid-base strength on catalyst performance.
    [Show full text]
  • Chemical Compatibility Chart
    Chemical Compatibility Chart 1 Inorganic Acids 1 2 Organic acids X 2 3 Caustics X X 3 4 Amines & Alkanolamines X X 4 5 Halogenated Compounds X X X 5 6 Alcohols, Glycols & Glycol Ethers X 6 7 Aldehydes X X X X X 7 8 Ketone X X X X 8 9 Saturated Hydrocarbons 9 10 Aromatic Hydrocarbons X 10 11 Olefins X X 11 12 Petrolum Oils 12 13 Esters X X X 13 14 Monomers & Polymerizable Esters X X X X X X 14 15 Phenols X X X X 15 16 Alkylene Oxides X X X X X X X X 16 17 Cyanohydrins X X X X X X X 17 18 Nitriles X X X X X 18 19 Ammonia X X X X X X X X X 19 20 Halogens X X X X X X X X X X X X 20 21 Ethers X X X 21 22 Phosphorus, Elemental X X X X 22 23 Sulfur, Molten X X X X X X 23 24 Acid Anhydrides X X X X X X X X X X 24 X Represents Unsafe Combinations Represents Safe Combinations Group 1: Inorganic Acids Dichloropropane Chlorosulfonic acid Dichloropropene Hydrochloric acid (aqueous) Ethyl chloride Hydrofluoric acid (aqueous) Ethylene dibromide Hydrogen chloride (anhydrous) Ethylene dichloride Hydrogen fluoride (anhydrous) Methyl bromide Nitric acid Methyl chloride Oleum Methylene chloride Phosphoric acid Monochlorodifluoromethane Sulfuric acid Perchloroethylene Propylene dichloride Group 2: Organic Acids 1,2,4-Trichlorobenzene Acetic acid 1,1,1-Trichloroethane Butyric acid (n-) Trichloroethylene Formic acid Trichlorofluoromethane Propionic acid Rosin Oil Group 6: Alcohols, Glycols and Glycol Ethers Tall oil Allyl alcohol Amyl alcohol Group 3: Caustics 1,4-Butanediol Caustic potash solution Butyl alcohol (iso, n, sec, tert) Caustic soda solution Butylene
    [Show full text]
  • Ep 0095783 A2
    Europaisch.es Patentamt European Patent Office ® Publication number: 0 095 783 A2 Office europeen des brevets ® EUROPEAN PATENT APPLICATION © Application number: 83105450.7 ® Int. CI.3: C 07 C 45/74, C 07 C 49/203, C 07 C B 01 J ^ 49/603, 29/04, @ Dateof filing: 01.06.83 B 01 J 21/16 (§) Priority: 02.06.82 US 384212 @ Applicant: UNION CARBIDE CORPORATION, Old Ridgebury Road, Danbury Connecticut 06817 (US) @@on ~ ... ,.... ,... nun on ^(7?) Inventor: Reichle, Walter Thomas, 158 Mountain Avenue, j^J/^ Warren New Jersey 07060 (US) @ Representative : Wuesthoff , Franz, Dr.-lng. et al, Patentanwalte Wuesthoff -v. Pechmann-Behrens-Goetz @ Designated Contracting States : DE FR GB Schweigerstrasse 2, D-8000 Miinchen 90 (DE) @ Catalyzed aldol condensations. Heat treated anionic clay mineral is an improved catalyst for the conversion of acetone to mesityl oxide and isophorone as well as for the aldol condensation of other carbonyl-contain- ing compounds. BACKGROUND OF THE INVENTION This invention pertains to aldol condensations catalyzed by heat-treated synthetic anionic clay minerals ana more particularly to the use of these catalysts ror the conversion of acetone to mesityl oxide and isophorone. The alaol condensation of active hydrogen-containing organic carbonyl compounds has found wide use in the chemical industry for the synthesis of a myriad of organic compounds. The earliest catalysts used for this conaensation reaction were bases, such as, alkali metal hydroxides which have been used for the production of 2-ethylhexanediol-l, 3, 2-ethylhexanol-l, diacetone alcohol, isopnorone, mesityl oxide, methylisoamyl ketone, and methylisobutyl ketone. A variety of methods has been disclosed in the literature for converting, for example, acetone by aldol condensation into a wide spectrum of products particularly isophorone and mesityl oxide which are used in industrial solvents and as chemical intermediates for resins, dyes, intersecticiaes.
    [Show full text]