news¬es
NOVEMBER 13, 1998 VOLUME 9, NUMBER 8 THE ROCKEFELLER UNIVERSITY
Friday lecture Torsten Wiesel set to retire after RU’s Müller will discuss “historic” presidency at RU evolution of eukaryotes ROBIN THOMAS orsten Wiesel, president of The During the Wiesel administration, the ssociate Professor and head of Rockefeller University, will retire university also established six interdisci- laboratory Miklós Müller is an Tnext month after serving the uni- plinary research centers, in the areas of AM.D. with an interest in the versity for fifteen years, seven of those as human genetics, immunology, sensory diversity of life and its evolution; Charles president. neuroscience, Alzheimer’s research, chem- Darwin was an evolutionist with medical A neurobiologist who shared the istry, and physics and biology. To support training. A bit of Darwin will creep into 1981 Nobel Prize in Medicine, Wiesel these centers, appointments and related the Friday lecture today (Nov. 13) when joined the Rockefeller faculty in 1983 to capital improvements, the university has Müller discusses “Evolutionary head a new laboratory of neurobiology, raised $190 million in private gifts during Adaptations to Anaerobic Life in and later that year he was named the the seven years of Wiesel’s presidency. Eukaryotes.” university’s Vincent and Brooke Astor In addition, Wiesel set and met his Free-living and parasitic unicellular Professor. He became the university’s goals for achieving a balanced operating eukaryotes (organisms whose cells have seventh president in 1992. budget, rebuilding and beautifying the nuclei) have long been the focus of Under Wiesel’s direction, The campus, strengthening the campus com- Müller’s work at RU. In the past quarter Rockefeller University formulated and munity and establishing links with con- century, he became interested in the successfully implemented a strategic aca- stituencies and communities beyond the question of how some of these organisms demic plan to enhance research and edu- university’s gates evolve in environments without oxygen? cation. As a result, the university now As told in the following pages, the The main adaptive change to be noted has 74 active laboratories, with 30 Wiesel presidency has enjoyed resound- was the loss of mitochondria, the directed by newly appointed or promot- ing success. The university community is organelles that supply a cell with energy. Torsten Wiesel is retiring next month after seven ed faculty members, including 16 at the grateful for Torsten Wiesel’s service and While some of the species have no rem- years as president of The Rockefeller University. rank of tenured professor. wishes him well in his future pursuits. nant of this organelle, others have a structure called a hydrogenosome—a structure discovered in Müller’s lab at RU 25 years ago—that has a common origin An interview with President Wiesel with mitochondria. Müller believes that the study of such metabolic adaptations Recently Geoffrey Montgomery, assistant can help scientists elucidate the origin of to the president for special projects, and eukaryotes. Mariellen Gallagher, vice president of com- In agreement with a growing number munications and public affairs, met with of other researchers, he assumes that the retiring President Torsten Wiesel to get his meeting of two organisms was the criti- thoughts on his presidential tenure at RU. cal step in the emergence of the eukary- otic cell, a process he will discuss in GM: Before becoming president of RU, detail in his talk. “This is the only event did you ever envision yourself as the head we can safely deduce,” he notes, “but we of an institution? cannot find support for the broadly accepted view, found in may textbooks, TW: Not really, I didn’t have any that among the living organisms we can ambitions in that direction. I was chair- find forms that reveal the step-by-step man of the Department of Neurobiology assembly of the cell. Without exception, at Harvard. But there the current chair- extant eukaryotic organisms seem to man, being good friends with me, asked Wiesel chats with students at an RU picnic. have diverged from a common ancestor me if I would consider running the place that had all major components charac- for a while. So, it was more a matter of but my training was a long time ago. TW: Genetics is probably the area teristic of the eukaryotic cell. In addition collegiality than one of me striving for And the whole field of molecular biology that has come to the forefront for all of the position. and genetics has developed during my us in biology. Certainly if I did start out In some ways I feel that this presi- time as a scientist. This has been one of today, genetics would be part of my dency [at RU] has been a little bit like the great challenges of this job. armament for studying problems in neu- that—it has been quite congenial and In some ways I have felt that I was roscience. But I still would go into neu- collegial. not particularly suited in terms of my roscience. scientific competence to have such a GM: You’ve said that in your Harvard broad mandate. Therefore, I have come GM: Was your background in psychiatry days, a lot of administration was done in to rely very much on my colleagues on of any help to you in this job? the hallway. Here at RU, it is a little bit the faculty for consultation and discus- more formal. sion; I also consulted with scientists TW: (Laughs) I think perhaps my from outside the university for advice. attitude with people, my willingness and Associate Professor Miklós Müller will challenge TW: You are right. It’s a bigger assign- One of the attractive aspects of being interest in listening to them, has been of conventional textbook explanations of eukaryotic ment because being president is a greater president is that it has expanded my sci- some help. I should say that I was never evolution at the Friday lecture today (Nov. 13). responsibility. Here there is such a broad entific interests. As a working scientist, a card-carrying psychiatrist. I never com- range of science—from physics to clini- doing or discussing new experiments mitted myself to psychiatry as a profes- to increasing specialization, functional cal science. I was trained in medicine, every day, you rarely have the time or sion—but perhaps that training does losses played a significant role in the fur- opportunity to venture too far from the give you a more open perspective about ther evolution of this ancestral cell.” questions you are studying in your labo- people. “My major statement,” says Müller, is Campus reflections ratory. that the conventional explanation “ain’t 2 MG: Have you found the people here necessarily so. One has to look at the GM: Are there any areas of science, out- interesting? available evidence with a fresh eye.” 3 Come one, come all side your own, that you have been particu- Müller’s talk will begin at 3:45 p.m. larly attracted to—that if you were young see WIESEL, page 3 in Caspary Auditorium and will be pre- and starting out today you could imagine ceded by a tea at 3:15 p.m. in Abby 4 Calendar yourself going into? Aldrich Lounge. All are welcome. 2 news¬es NOVEMBER 13, 1998
The RU community reflects on Anniversary-Retirement Dinner Torsten Wiesel’s tenure The annual Anniversary-Retirement Dinner will be held on Mon., Nov. 23 at 6:30 p.m. in Abby Aldrich Lounge. Any retirees on campus who did not receive an invitation and would like to attend should call Amy Ites in Human Resources Office, x8300, by the end of the day today, Fri., Nov. 13.
Special Honoree Verline Barrett Hoover Gonzalez Torsten Wiesel Mario Castillo Jules Hirsch David Cowburn Elizabeth Horak 45 Years: James E. Darnell Rose Lawrence T.P. King Angie Dohnert Edgar Gordon Lewis Eugene Roth Herbert Gibbs Robert Luckey Victor Wilson Cynthia Payne Aleksandar Angela Piperno Milutinovic 40 Years: Anne-Marie Scully Herbert Negron Paul Rosen Paulette Zabriskie Frank O’Brien Mary Xikis Geraldine Perdomo Retirees: Julien Rouse 25 Years: William Agosta Vera Smith David Rockefeller and Torsten Wiesel Norma Akande Leonard Beaton Iris Vallecilla Vincent Alleyne Isaias Coats Sandra Walsh David Rockefeller, Honorary the talents, insights, and energy of oth- Chairman of the Board ers in accomplishing our shared goals Working with Torsten over the past and dreams. His inclusive style brought Tom Muir, Assistant Professor seven years has given me an apprecia- trustees, faculty and staff together in a and Head of Lab tion for the qualities that have made shared purpose. In a real sense, he has He was proactive in getting chemistry Potpourri him both a great scientist and a great made us feel that his accomplishments back here, and he was very persuasive in administrator. His wit, warmth and are our accomplishments. He is an convincing all of us that there was a charm, his wide-ranging knowledge, uncommon individual and his is truly a chance for interdisciplinary research, TRIP deadline his appreciation for culture and art historic presidency. that that was the environment we were Today, Fri., Nov. 13, is the last and, most importantly, his firm insis- getting into. day to return your forms to tence upon the highest standards of Maria Karayiorgou, Assistant Human Resources for the excellence have made Rockefeller Professor and Head of Lab Fred Bohen, Transportation Reimbursement University a stronger institution. I consider myself fortunate and hon- Executive Vice President Incentive Program (TRIP). ored that I was recruited under President Wiesel has countless attrib- Marnie Imhoff, Vice President Torsten. His personal scientific interest utes as a leader, but one stands out for Purchasing Corner for Development in neurobiology, behavior and psychi- me. He is purposeful and tenacious in Lab Safety has recommended For Torsten, fund-raising was an atric diseases influenced my decision to pursuing his larger goals and objectives, that the nitrile gloves in the store- extension of the community and colle- come to RU a great deal, and he has and not easily distracted or sidetracked. room be replaced with the follow- giality that he created on campus. inspired my work for the last couple of He aims very high, in both big issues, ing Nitrile High Five gloves: Glove Torsten has a unique ability to make years. I’ll miss him more than he like faculty appointments, and small but Nitrile Powder Free, small, G3801; people feel connected and privileged to knows. important matters, like how things look. medium, G3802; large, G3803. be a part of the extraordinary scientific As a result, his impact here is both broad enterprise at the university. I believe Michael John, and deep. And, I believe, lasting. that the qualities our benefactors Captain of Security news¬es is published each Friday admire in him most are his personal Our goal at the Security Department throughout the academic year by integrity, astute judgment, uncommon has been to bring our staff to a higher The Rockefeller University, leadership ability and his daunting level of professionalism. Dr. Wiesel’s 1230 York Avenue, work ethic. He has inspired all of us to professionalism and charming character New York, NY 10021-6399 Phone: 212-327-8967 accomplish more than we ever thought are a perfect example to emulate. http://www.rockefeller.edu/pubinfo/news_notes.html possible. Another thing was his support. Dr. Wiesel has always supported the Torsten N. Wiesel, President Mariellen Gallagher,Vice President for Richard Furlaud, Chairman Security Office in maintaining a high Communications and Public Affairs Emeritus of the Board of level of security on campus. Joseph Bonner, Acting Director of Communications Trustees Lisa Stillman, Editor It has been a pleasure and a privi- Jeffrey Friedman, Professor and Paul Focazio, Communications Associate and lege to work with Torsten. We faced Head of Lab Calendar Editor enormous challenges together, but As Torsten finishes his term as presi- Robert Reichert, Photography Media Resource Service Center, Pre-press and Torsten always transformed them into dent, he leaves an institution that is far Offset opportunities to make the university a stronger than it was when he began. We better, stronger place. Torsten instinc- are all grateful for his immense efforts Ideas and submissions can be sent interoffice (Box 68), tively grasped the process of effective on behalf of the university. I look for- by electronic mail (newsno), or by fax (212-327-7876). Copyright, 1998. The Rockefeller University. For leadership; he knew when to be ward to continuing interactions with permission to quote or reprint material from this newslet- patient, when to push and, most him as he returns to the laboratory as an Wiesel was a professor at RU before being tapped ter, please contact the editor. The Rockefeller University is importantly, he knew how to harness esteemed member of our faculty. for the presidency. an equal opportunity/affirmative action employer.
Torsten N. Wiesel SEVEN YEARS OF EXCELLENCE : HIGHLIGHTS FROM PRESIDENT WIESEL’S ADMINISTRATION
DECEMBER 1991 SEPTEMBER 1992 JUNE 1994 ¨ Torsten N. Wiesel appointed President ¨ The John D. Rockefeller, Jr., and ¨ The Board of Trustees approves of The Rockefeller University. David Rockefeller Research Building Wiesel’s Academic Plan, which intensi- opens. fies the renewal of the faculty, leading to new labs and academic centers. MAY 1993 ¨ RU Adjunct Professor and Visiting JUNE 1995 Physician Lewis Thomas is presented ¨ University announces first balanced with the first Lewis Thomas Prize, operating budget since 1987. honoring the scientist as poet. JULY 1995 50th Anniversary of DNA Discovery: Maclyn McCarty and Wiesel OCTOBER 1993 ¨ RU Professor Jeffrey Friedman,* ¨ Professor Günter Blobel* receives the FEBRUARY 1994 collaborating with RU Professor Stephen Albert Lasker Basic Research Award, for ¨ RU celebrates the 50th anniversary of Burley,* reports that leptin, the hormone “landmark discoveries concerning the the discovery by RU researchers Oswald made by the ob gene, regulates body process by which intercellular proteins Avery, Colin MacLeod and Maclyn McCarty weight by curbing food intake and Lewis Thomas Prize: Lewis Thomas and Wiesel are targeted across cell membranes.” in 1944 that genes are made of DNA. increasing energy expenditure.
*HHMI investigator NOVEMBER 13, 1998 news¬es 3
TW: I have been very pleased with Come join us... the appointments that have been made during my presidency. We now have a President Wiesel will be feted at a round younger group of faculty. The average of receptions celebrating his presidency. age decreased by about a decade. I’m If you did not receive your invitation, particularly pleased that during my please call Public Affairs, x8967. administration three women have received tenured appointments. I have Members of the South Campus also been proud of the creation of con- Monday, November 16 ceptual centers in different areas of sci- 2:30 -4:30 p.m. ence; the Center for Studies in Physics Welch Hall and Biology was the first; it’s the kind of thing, I think, a place like this should Faculty and Students do. The center has been able to get Tuesday, November 17 grants from foundations to support sci- 2:00-4:00 p.m. entists who are doing very interesting Weiss Café Wiesel inaugurated the new playground at the RU work, but who don’t have such an easy Members of the North Campus Child and Family Center. time getting money from the NIH because of the unconventional nature of Wednesday, November 18 their studies. 2:00-4:00 p.m. WIESEL, continued from page 1 I am also very pleased with the bridge Abby Aldrich Rockefeller Hall and the plaza [renovation project]. It is not TW: Yes. Scientists in general are an academic achievement, but I certainly ple a sense of freedom and a sense that cortex, which of course has been my curious about things, so I feel very had to fight for that. I am very grateful to they are in an intellectual community that major scientific interest over the years. happy and comfortable here being the Board and the community for their is supportive and stimulating. So I think this will be an ideal environ- around the people in this scientific vil- help. I also think that the expansion of the ment for me both collegially and in lage and interacting with them. I really children’s school is really important because MG: What’s your secret? terms of my research. enjoy my day-to-day interaction with the you want to have young families come here. I have outside obligations, too. I’ve nonscientists on campus. I feel a sense of Many scientists are married to other scien- TW: I have probably been lucky. Money been elected president of the International camaraderie with everyone. It’s a warm tists, so you have to accommodate their has come in, so we have had more appoint- Brain Research Organization, which is place. needs, more so in this country than in ments, and there has not been unpleasant based in Paris, and I will continue to be Europe. I’m also proud of the dining room competition between different research involved in the Pew Charitable Trusts, GM: Was faculty and administration here in Caspary; we tried to create an areas. I appreciate my relationship with the chairing the scientific advisory board for interaction enhanced by the academic plan- atmosphere for the scientists and others Board, which has given me strong and con- Pew Scholars and the Pew Foundation ning process? working at the university that is friendly sistent support. I very much enjoyed my Latin American Fellows program. I’ve also and warm, and again I wish I had done interactions with David Rockefeller and been elected the president of the TW: Yes, I think the plan was very more of this. It sets a tone that the universi- Richard Furlaud, Chairman of the Board. To Neuroscience Division of the McKnight important, and the process of academic ty community enjoys, and I think it helps to me, the most surprising thing is that I have Foundation; they give money for assistant planning was more important than the create an environment where good science been able to raise so much money. I can’t professors and also to neuroscientists in plan itself, both to the faculty and to the can flourish. understand it at all. mid-career, which is very important, Board. The faculty forum that we began because most private programs just sup- last year for the heads of laboratories GM: Isn’t that part of the history of MG: People don’t donate unless they are port faculty in the early years of their was also important. I’m pleased that it RU— freeing scientists to do creative work? confident about the vision of the place. career. I also chair the Committee for was organized through a faculty initia- Human Rights associated with the NAS, tive. And much more could be done. TW: Yes. Part of my task has been to TW: We have a very good develop- NAE and IOM. I don’t think it has any avoid burdening the faculty with admin- ment office. Marnie [Imhoff] is wonder- relationship to this job, but I don’t mind MG: Is there a Rockefeller tradition of istrative tasks and to allow the investiga- ful, and Fred Bohen and others have using my Nobel Prize for good purposes. education and, if so, can you describe it? tors to concentrate on their science. been a wonderful management team. They deserve a great deal of the credit. MG: People usually work on their golf TW: I think the hallmark of The GM: Has that helped you recruit out- game when they retire. It doesn’t sound as Rockefeller University is how we leave standing scientists here—that they saw this MG: People talk about your vitality and though you are retiring. people very much on their own in the as a place where they could really concen- your zest for life. At a Women and Science labs. I think most student learning takes trate on their science? forum, you said, “Take a baby aspirin every TW: It will be nice not to be so sched- place in the labs. In contrast to many other day.” Do you? uled. I have a lot of reading to do. I have universities, we pay the students a stipend TW: I think so. It is an interesting not been able to keep up with the scientific for six years instead of putting them on process—the dynamics of an institution. TW: Yes, I take a baby aspirin every day. literature very well. You know, the presiden- research grants. In many places, an incom- Most institutions have periods of ascent It seems to me that some people are old cy is basically a service job. You are serving ing student would be supported for a year and periods of decline. Harvard Medical when they are 20, while other people keep a community. It has been an assignment or two when they are given course work; School as a whole, for instance, has having an interest in life. I suppose that I that has given me a sense of responsibility then, when they get in the lab, the univer- always been at the leading edge because am still interested in exploring, learning. and duty to try to do as well as possible. I sity tells them they have to be supported it is so big, even if different departments feel a little like an artist who has been asked by a grant. This, therefore, does not allow at different times have gone into decline. MG: What’s next? to be the curator of a museum that is devot- the student free choice to study what he or But we are so small by comparison that ed to living artists doing all kinds of inter- she wants to do, and free choice often mistakes can be critical—losing a few TW: I will have an office here in the esting and important work. I’m very leased leads to important discoveries. major laboratories can change the tenor of Rockefeller Research Building, close to that it has gone well, but once you have science on the whole campus. Excellence Charles Gilbert, with whom I collaborat- done science and felt the day-to-day excite- MG: What has been your proudest is a delicate flower. You really need to be ed for many years. He’s working on sys- ment of doing experiments and making dis- accomplishment as president? sensitive to what is required to give peo- tems neuroscience, studying the visual coveries, nothing else comes close.
Center (ADARC) for the City of New York Cour his laboratory, tesy of Roderick MacKinnon and appoints ADARC scientific director, together with David Ho, as a professor. members of the Chait Copyright Amgen, Inc. DECEMBER 1996 laboratory, ¨ Professor David Ho is named announce Time Magazine’s Man of the Year. that they have solved the NOVEMBER 1997 long-elusive ¨ Board Chairman Richard Furlaud structure of the potassium ion channel. SEPTEMBER 1995 announces the successful conclusion of ¨ RU receives $38.4 million in gifts and the three-year public phase of the MARCH 1998 pledges in fiscal year 1994–1995, mak- university’s Campaign for Faculty ¨ Board announces that Trustee Richard ing it the most successful fund-raising Development, which exceeds its three- B. Fisher will succeed retiring chairman Plaza redesign year in the history of the institution. year goal of $82 million by more than Richard Furlaud on July 1, 1998. JUNE 1998 $4 million. ¨ Arnold J. Levine elected eighth JUNE 1996 ¨ The Board of Trustees approves plans president of The Rockefeller University, ¨ In accord with a plan voted on by its APRIL 1998 to build a bridge connecting the South to succeed President Wiesel after the fall Board of Trustees, the university affiliates ¨ Professor and HHMI investigator campus area to Scholar’s Residence and Board of Trustees meeting. with the Aaron Diamond AIDS Research Roderick MacKinnon and members of to beautify the Plaza area. NOVEMBER
13 29NOVEMBER calendarofevents http://www.rockefeller.edu/rucal THE ROCKEFELLER UNIVERSITY — Please Post
FRIDAY, NOVEMBER 13 12:00 p.m. Expression Monitoring of 10:00 a.m.-12:00 p.m. Mirror Neurons and 10:00 a.m.-11:30 a.m. How to Optimize Colon Cancer with DNA Microarrays. the Neural Basis of Social Understanding. THE ROCKEFELLER UNIVERSITY Your DNA Sequence Using Your Core Daniel A. Notterman, Dept. of Molecular Vittorio Gallese, Institute of Human Physiol- Facility. Dale Baskin, Field Applications Biology, and Chairman, Committee on the ogy, Parma, Italy. The Duration of Memory. Friday Lectures Specialist, PE Applied Biosystems. Lecture. Health Professions, Princeton U. Clinical Tim Tully, Cold Spring Harbor Laboratory. 110B Nurses Residence. Refreshments prior Research Seminar. 110B Nurses Residence. Neurobiology of Behavior and Learning Events are held in Caspary Auditorium at to lecture. Contact Anthony Rully, 327-7545. Seminar. 110 Rockefeller Research Building. 3:45 p.m. Tea is served in Abby Aldrich 3:45 p.m. The Molecular Logic of Olfactory Contact Fernando Nottebohm, 914-677-3059. Rockefeller Lounge at 3:15 p.m. All are 10:00 a.m. and 1:00 p.m. Gene Synapses Perception. Richard Axel, Higgins Professor, welcome. Biochemistry and Pathology, Columbia U. MONDAY, NOVEMBER 23 and Long-term Memory. Eric Kandel, FRIDAY, NOVEMBER 13 Columbia U. Cocaine Addiction: A Collab- College of Physicians and Surgeons, and 11:00 a.m. Developmental Regulation of Evolutionary Adaptations to Anaer- oration between Learning and Pharmaco- Investigator, HHMI. Seminar. Auditorium, VDJ Recombination at the TCR Alpha/ obic Life in Eukaryotes. Miklós logy. Peter Kalavis, Medical U. of South Rockefeller Research Laboratories, Delta Locus. Michael S. Krangel, Professor, Müller, Associate Professor, RU. Carolina–Charleston. Neurobiology of MSKCC, 430 East 67th St. Tea 3:00 p.m. Immunology, Duke U. Immunology Seminar. 116 Rockefeller Research Laboratories, Behavior and Learning Seminar. 110 Rocke- FRIDAY, NOVEMBER 20 feller Research Building. Contact Fernando THURSDAY, NOVEMBER 19 MSKCC, 430 East 67th St. CANCELED Nottebohm, 914-677-3059. 12:00 p.m. Persisting Problems in Tuber- culosis: Latent Infection, Chronic Persis- 12:00 p.m. The Role of Integrins and 12:00 p.m. Structural Studies on Signaling tence and Antibiotic Tolerance. John Integrin Antagonists in Angiogenesis. by SH2 and SH3 Domains. John Kuriyan, McKinney, Albert Einstein College of Medi- Martin Friedlander, Associate Professor, Dept. The Arts and Professor, RU, and Investigator, HHMI. Cel- cine. CFAR Seminar. 6th Floor Conference of Cell Biology, Scripps Research Institute, lular Biochemistry and Biophysics Seminar. Room, ADARC, 455 First Ave. Chief of Retina, Division of Ophthalmology, Other Events 116 Rockefeller Research Laboratories, Scripps Clinic. Seminar. 301 Weiss. MSKCC, 430 East 67th St. 12:00 p.m. The Role of Cytoplasmic Dynein FRIDAY, NOVEMBER 13 in Mitosis, Transport and Development. 12:00 p.m. Recombinant Vesiculoviruses: 12:00 p.m. Tri-institutional Noon Recitals. 1:15 p.m.-2:15 p.m. Regulation of Natural Richard Vallee, Professor, Cell Biology, Studies of Assembly, Targeting and Vaccine An die Musik, string, wind and piano quintet, Killer Cell Cytotoxicity by Killer Cell Massachusetts Medical School. Biochemistry Applications. Jack Rose, Yale U. School of performing works by Mozart and others. Immunoglobulin-like Cell Receptors. Lecture. E-115 CUMC, 1300 York Ave. Medicine. CFAR Seminar. 6th Floor Confer- Ruth Westheimer, narrator, “Goldilocks and Bo Dupont, Professor, Immunology Program, ence Room, ADARC, 455 First Ave. the Three Bears,” composed by Bruce Adolphe. MSKCC. Immunology Seminar. Weill 12:00 p.m. Mammalian Fertilization: Profile Caspary Auditorium. Free admission. Open Auditorium, C-200 CUMC, 1300 York of a Sperm Receptor. Paul Wassarman, 12:30 p.m. The Role of Fibrillin-1 in Mouse to RU/CUMC/NYPH/MSKCC community Ave. Contact Michele Lavarde, 746-6452. Professor, Dept. of Cell Biology and Anatomy, and Human Scleroderma. Constantin Bona, and guests. Mt. Sinai School of Medicine. Endocrinology Professor, Microbiology, Mt. Sinai Medical MONDAY, NOVEMBER 16 and Reproductive Biology Seminar. 301 Weiss. School. Immunology Lecture. Second Floor 7:00 p.m. Chinese Class and Yan Xin 11:00 a.m. Structure, Function and Engi- Conference Room, HSS, 535 East 70th St. Qigong Practice. Didi Waters, writer and neering of a T cell Receptor. David M. 2:00 p.m. Analysis of Gene Expression artist. 17th Floor Weiss. Contact Wenyong Kranz, Associate Professor, Dept. of Biochem- Patterns. Uri Alon, Postdoctorate, Depts. of 4:00 p.m. Hepatitis C: Progress and Chal- Zhang, 327-7922. istry, U. of Illinois. Immunology Seminar. Molecular Biology and Physics, Princeton U. lenges. Charles Rice, Professor, Dept. of 116 Rockefeller Research Laboratories, Starr Center for Human Genetics Seminar. Molecular Microbiology, Washington U. TUESDAY, NOVEMBER 17 MSKCC, 430 East 67th St. 305 Weiss. Rescheduled from October 27. School of Medicine. Seminar. 301 Weiss. 7:30 p.m. Rockefeller University Film Series. Shall We Dance? Japan, 1997. Color. Japanese 4:00 p.m. Surprising Roles for the Matrix 4:00 p.m. Proliferation and Pathogenesis 4:30 p.m. Electrical Measurements of Protein with English subtitles. 118 min. Directed Metalloproteinase Matrilysin in Normal of a Chemical Called Poliovirus. Eckard Conformational Changes in Voltage Depen- by Masayuki Suo. Caspary Auditorium. and Neoplastic Processes. Lynn M. Matrisian, Wimmer, Professor and Chairman, Dept. of dent Ion Channels. Enrico Stefani, Professor Free admission. Open to RU/CUMC/NYPH/ Professor, Dept. of Cell Biology, Vanderbilt Molecular Genetics and Microbiology, SUNY and Vice Chair of Research, Dept. of Anesthe- MSKCC community and guests. U. School of Medicine. Cell Biology and at Stony Brook. LFKRI Research Seminar. siology, U.C.–Los Angeles. PBMM Research Genetics Seminar. Well Auditorium, C- Lower Level Conference Room, New York Seminar. Weill Auditorium, CUMC, 1300 WEDNESDAY, NOVEMBER 18 200 CUMC, 1300 York Ave. Blood Center, 310 East 67th St. Tea 3:45 p.m. York Ave. 8:00 p.m. Peggy Rockefeller Concerts. Contact Rosanna Martinez, 570-3357. Kyung-Wha Chung, violin, and Itamar Golan, TUESDAY, NOVEMBER 17 TUESDAY, NOVEMBER 24 piano, performing works by Shubert, Bartók 4:00 p.m. Synthesis of Natural Product 8:00 p.m. From Flies to Mammals: Study- 2:00 p.m. Oligonucleotides, DNA and and Schumann. Caspary Auditorium. Inhibitors of Protein Phosphatases. James S. ing Neural Development and Function. Protein Microchips: Their Manufacturing, Contact Cathy Rogers, 327-8437. Panek, Professor, Dept. of Chemistry, Boston Yuh Nung Jan and Lily Yeh Jan, Professors, Properties and Application. Andrei U. 116 Rockefeller Research Laboratories, Physiology and Biochemistry, and Investiga- Mirzabekov, Director, Engelhardt Institute of FRIDAY, NOVEMBER 20 MSKCC, 430 East 67th St. Tea 3:30 p.m. tors, HHMI, U.C.–San Francisco. Harvey Soci- Molecular Biology, Moscow, Russia, Senior 12:00 p.m. Tri-institutional Noon Recitals. ety Lecture. Caspary Auditorium. Reception Scientist, Center for Mechanistic Biology Karen Gomyo, violin, and Rohan De Silva, WEDNESDAY, NOVEMBER 18 7:30 p.m. Contact Oneida Cintron, 824-7728. and Biotechnology, Argonne National Labo- piano, performing works by Janácek, Mozart, 11:00 a.m. hMrell/hRad50: Linkage of ratory. Starr Center for Human Genetics Tchiakovsky and Wieniawski. Caspary Double Strand Break Repair to the Cel- FRIDAY, NOVEMBER 20 Seminar. 301 Weiss. Auditorium. Free admission. Open to RU/ lular DNA Damage Response. John Petrini, 9:00 a.m.-5:00 p.m. Molecular Biology Near CUMC/NYPH/MSKCC community and guests. Assistant Professor, Laboratory of Genetics, the Millennium: A Symposium Honoring 4:00 p.m. Role of Receptor Phosphatases U. of Wisconsin Medical School. Weekly the Scientific Contributions of Jerard in Axonal Guidance and Target Recognition. Research Seminar. 305 Weiss. Contact Hurwitz. Paul Berg, Stanford U. Medical Eduardo Macagno, Professor, Biological Shauna Seliy, 327-8655. Center; David Baltimore, Caltech; Stanley Sciences, Dean, Graduate School of Arts N Cohen, Stanford U.; Kenneth J. Marians, and Sciences, Columbia U. Progress in Neuro- The Calendar of Events is published Fridays through- MSKCC; Paul A. Marks, MSKCC; Carol Prives, science Seminar. Weill Auditorium, CUMC, out the academic year. Deadline for submitting events is 12:00 p.m. Tuesday. Events submitted by the Columbia U.; Danny Reinberg, Robert Wood 1300 York Ave. Tea 3:45 p.m. PAID First-Class U.S. postage Tuesday two weeks before the event will be announced Johnson Medical School, U. of Medicine NY New York, in two consecutive calendars—space permitting. and Dentistry of New Jersey; Lucille Shapiro, 4:00 p.m. DNA Nanotechnology. Nadrian Permit no. 7619 Events may be submitted via e-mail to Stanford U. School of Medicine; Ann Skalka, Seeman, Professor, Dept. of Chemistry, NYU. [email protected], through the World Wide Fox Chase Cancer Center; Stewart Shuman, Center for Studies in Physics and Biology Web (http://www.rockefeller.edu/rucal/ru-entry.html), MSKCC; S. Lawrence Zipursky, U.C.–Los Seminar. B Level Conference Room, Smith or by fax (212-327-7876). Contact Paul C. Focazio Angeles. Seminar. Auditorium, Rockefeller Hall Annex. Tea 3:30 p.m. (212-327-8969) for more information. Research Laboratories, MSKCC, 430 East To reserve space for on-campus events, e-mail 67th St. For more information, call 639-5890. WEDNESDAY, NOVEMBER 25 [email protected] or contact Julie Ranton-Francis via fax (212-327-7876) or phone 12:00 p.m. Pathogenicity of SSA/Ro-SSB/ (212-327-8072). Items will not be listed in the calendar La Antibodies in Congenital Heart Block- without a previously confirmed room reservation. neonatal Lupus. Jill Buyon, Vice Chair-
To subscribe to the Calendar of Events mailing person, Dept. of Rheumatology, Hospital notes list, send e-mail to macjordomo@comm. for Joint Diseases. Clinical Research Seminar. rockefeller.edu with SUBSCRIBE RUCAL-L 110B Nurses Residence. &