DOCSLIB.ORG

Uses and Administration Adverse Effects, Treatment, and Precautions

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Uses and Administration Adverse Effects, Treatment, and Precautions 2006 Miotics activity, an enzyme likely to be involved in the metabolism of action similar to that of ecothiopate iodide (p. 2007.2). It Uses and Administration of cydopentolate. has been used as a 0.125 or 0.25% ophthalmic solution in Cyclopentolate hydrochloride is a tertiary amine antimusca­ l. Awan KJ. Adverse systemic reactions of topical cyclopentolate the treatment of open-angle glaucoma and in the diagnosis rinic with actions similar to those of atropine (p. 1310.3). It hydrochloride. Ann Ophthalmol l976; 8: 695-8. and management of accommodative convergent strabismus. is used to produce mydriasis and cycloplegia (p. 2000.2) for 2. Bauer CR. et al. Systemic cyclopentolate (Cyclogyl) toxicity in the Pediatr 92: ophthalmic diagnostic procedures and also in the treatment newborn infant. 1 1973; 501�5. 3. Fitzgerald DA, et al. Seizures associated with 1% cyclopentolate i of uveitis and iritis (p. 1615.1). It acts more quickly than eyedrops. J Paediatr Child Health 1990; 26: 106-7. Preparat ons atropine and has a shorter duration of action; the maximum 4. Demayo AP, Reidenberg MM. Grand mal seizure in a child 30 minutes mydriatic effect is produced 30 to 60 minutes after after Cyclogyl (cyclopentolate hydrochloride) and 10% Neo-Synephrine Pharmacopoeial Preparations (phenylephrine hydrochloride) eye drops were instilled. Abstract: USP 36: instillation, and may persist for up to 24 hours or longer in Demecarium Bromide Ophthalmic Solution. Pediatrics 2004; 113: 1390-1. Full version: http:f/pcdiatrics. some patients; the maximum cycloplegic effect is produced aappublications.org/cgi/reprim/ll3/5/e499 (accessed 24111/05) within 25 to 75 minutes and accommodation recovers within 6 to 24 hours. For diagnostic procedures, instillation of a 0.5% Interactions ophthalmic solution of cydopentolate hydrochloride, As for antimuscarinics in general (see Atropine Sulfate, repeated after about 5 to 15 minutes if necessary, is usually p. 1312.3). sufficient. Higher strengths have been used. In the treatment of uveitis and iritis, a 0.5% ophthalmic solution of cyclopentolate hydrochloride is instilled into the ProprietaryPreparations (details are given in Volume B) eye up to four times daily. Deeply pigmented eyes are more resistant to pupillary Single-ingredient Preparations, Arg. : Ciclopenal; Austral.: Cyclo­ dilatation and may require the use of a 1% solution. gyl; Belg.: Cyclogyl; Braz. : Ciclolato; Cicloplegico; Canad.: Ak­ Chile: China: For details of doses in children, see below. Pentolate; Cyclogyl; Diopentolate; Cyclogyl; Cyclogyl ('1\''i.it); Denm.: Cyclogyl; Fin.: Oftan Syklo; Fr.: Skiacol; Ger.: Zykolat-EDO; Gr.: Cyclogyl; Hong Kong: Cyclo­ Administration in children, For diagnostic procedures in gyl; Hung. : Humapent; India: Bell Pentolatet; Cyclate; Cyclo­ children, instillation of a I% ophthalmic solution of cyclo­ gik; Cyclogyl; Cyclopent; Dilate; Irl.: Mydrilate; Ital. : Ciclolux; pentolate hydrochloride, repeated after about 5 to 15 min­ Malaysia: Colircusi Cicloplejico; Cyclogyl; Mex. : Refractyl; Diclofenamide is an inhibitor of carbonic anhydrase with utes if necessary, is usually sufficient. Higher strengths Neth.: Cyclogyl; NZ: Cyclogyl; Port. : Cicloplegicedol; Midrioda­ properties similar to those of acetazolamide (p. 200 l.l). have been used. However, some recommend that vi; Rus.: Cyclomed (UHKJIOMM); Cycloptic (UHKJIOITTHK); S.Afr. : When given orally its effect begins within hour and lasts strengths greater than 0.5% should not be used in infants Cyclogyl; Singapore: Cyclogylt; Spain: Ciclopegic; Cicloplejico; I and that cyclopentolate should not be used at all during Swed. : Cyclogyl; Switz.: Cyclogyl; Thai.: Cyclogyl; Turk. : Siklo­ for 6 to 12 hours. Diclofenamide is used to reduce intra-ocular pressure in the first 3 months of life. mid; Sikloplejin; UK: Mydrilate; Ukr. : Cyclomed (l.(HKJIOMe.IJ;); In the treatment of uveitis, the BNFC suggests that a USA: Ak-Pentolate; Cyclogyl; Ocu-Pentolate; Pentolairt; glaucoma (p. 1999.1). The usual initial oral dose is I 00 mg every 6 to 12 hours until the desired response is obtained, 0.5% ophthalmic solution of cyclopentolate hydrochloride Venez. : Cyclogyl. followed by a maintenance dose of 50 mg every 8 hours. may be instilled into the eye 2 to 4 times daily; a 1% India: Cycdex; Cyclogyl-D; Cyclo­ Multi·ingredient Preparations. Didofenamide sodium has been given by injection. solution should be used for deeply pigmented eyes. pent Plus; Cyclopent-DM; Malaysia: Cyclomydril; S.Afr. : Cyclo­ mydril; Singapore: Cyclomydrilt; USA: Cyclomydril. Diclofenamide may be of benefit in hyper- and hypokalaemic periodic paralysis. Adverse Effects, Treatment, and Precautions Pharmacopoeial Preparations BP 2014: Cyclopentolate Eye Drops; As for Atropine Sulfate, p. 1312.1. USP 36: Cyclopentolate Hydrochloride Ophthalmic Solution. Preparations Eye drops of cyclopentolate hydrochloride may cause ....... .................... (details are given in Volume B) temporary irritation. ProprietaryPreparations Dapipra:z:ole Hydrochloride (USAN, r/NNM) Single-ingredient Preparations. Gr.: Oratrol; Ital.: Antidrasit; Abuse, Cyclopentolate eye drops have been abused. 1 One Spain: de, Da iprazole,. Chlorhy, Fenamide; Glauconidet. of 2 patients who did so had been instilling 200 to 400 AF-2139; Dapiprazol. hidrodoruro p drale d<:\ Dapiprazoli Hydrochlof!dum; Hidroc!oruro de drops of cyclopentolate into both eyes daily for about 4 . Pharmacopoeial Preparations months, presumably for its CNS effects, and had intense daplprazol; ,[lan\<1npa3olla f'14AP0><11opMA. USP 36: Dichlorphenamide Tablets. nausea, vomiting, weakness, and tremors on withdrawal. S,q,7,8·Tetril hydro-3-[2 -14·0'lolxh1-piper azinyilethyJJ··Hria­ l. Sato EH, et al. Abuse of cydopentolate hydrochloride (Cydogyl)· drops. N zolo[4,�-a]pyridine monohydrochioride 326: Engl 1 Med 1992; 1363---4. C:lfpN:,!-lCI:'361.9 . Dorzolamide Hydrochloride C45· ;_ . T}lf22 -!:PJ (di:rpiptazole;; 72822- 13.-0 (dapipraz;ole Hypersensitivity. Two children developed hypersensitivity hyctr��hJoride), (BANM, USAN, r/NNM) @ reactions shortly after the instillation of I% cyclopentolate ATC� S01EX02. Dorzolamid Hidrokloror: Dorzolamida, . tlidrodon.;ro de; hydrochloride eye drops into each eye.1 Both children . ATCVet -::-- QSQ iEX02, Dorzolamide, Chforhyd rate Dorzolamidhydro hlori�; initially had a facial rash but in one of them the rash later d�; · � iJJ\fil -· DS9U)Nl !(JX. Dorzolamidi hydrochloridu ; Hidroclorura de .dormlarr>ida; spread to include the arms and legs and was accompanied !11 (dorzolamide); by mild breathlessness. L-671152 MK-0507; i'vll<-'507; .Qop3onaMMAa I. Jones LWJ, Hodes DT. Possible allergic reactions to cydopentolate f11APQXf10PI11l. (45,65}-4,(Ethyiam!no)'5,6,dihydro-6-rrethyi-4H. thien (2,3'" hydrochloride: case reports with literature review of uses and adverse Dapiprazole hydrochloride is an alpha blocker given as eye ? reactions. Ophthalmic Physiol Opt 1991; II: 16-21. .blthiopyranc 2-S<Jiphonamide -dioxid� hyd ro;:hloride. drops to reverse mydriasis; it is also used in some countries 7/ .. CwH;0N,04S3;HCI'=360_9 in the management of glaucoma. Porphyria. The Drug Database for Acute Porphyria, com­ CA S-'- 120279-96- 1 (dorzotom ide); }30693-82-2 (dorto lamide piled by the Norwegian Porphyria Centre (NAPOS) and Preparations hyrjrochidride). the Porphyria Centre Sweden, classifies cyclopentolate as ......................... ATC --: SO! fC03 probably not porphyrinogenic; it may be used as a drug of ProprietaryPreparations (details are given in Volume B) ATC Ve t-- QSOI.ECOJ. first choice and no precautions are needed. 1 Single-ingredient Preparations. Austria: Benglaut; Gr.: Glamido­ UNit -- · QZ05366ElNl I. The Drug Database for Acute Porphyria. Available at: http:/lwww. lo; !tal.: Glamidolo; USA: Rev-Eyest. drugs-porphyria.org (accessed 25110/ll) Pharmacopoeias. In Bur. (see p. vii) and US. Ph. Eur. 8: (Dorzolamide Hydrochloride). A white or almost Systemic toxicity. Ten of 66 patients (29 males and 37 white, crystalline powder. Soluble in water; very slightly females) who received one drop of 2% cyclopentolate in soluble in anhydrous alcohol; slightly soluble in methyl each eye developed mild to moderate systemic toxicity; 9 alcohol. It exhibits polymorphism. of the I 0 were female.1 Toxic signs included physical USP 36: (Dorzolamide Hydrochloride). A white to off-white weakness, nausea, lightheadedness, changes in emotional crystalline powder. Soluble in water. Store at 15 degrees to attitude, unprovoked weeping, and loss of equilibrium; 30 degrees. Protect from light. tachycardia was always present but changes in blood pres­ sure were insignificant. Spontaneous recovery occurred within l hour to several days. Uses and Administration As with atropine, it has been recommended that Dorzolamide is a carbonic anhydrase inhibitor with actions cydopentolate eye drops should not be used during the first similar to those of acetazolamide (p. 2001.1). It is used in the 3 months of life because of the possible association with managen1ent of open-angle glaucoma, pseudo-exfoHative development of amblyopia. Systemic toxicity has also been glaucoma, and ocular hypertension (p. 1999.1 ), either alone reported in neonates given ocular cyclopentolate.2 or as an adjunct to a topical beta blocker. A 4-year-old boy with cerebral palsy and paraplegia Dorzolamide is given as eye drops containing dorzola­ suffered tonic-clonic seizures, facial flushing, and tachy­ mide hydrochloride equivalent to 2% of the base. For cardia 70 minutes after
Load more

Recommended publications
  • Classification of Medicinal Drugs and Driving: Co-Ordination and Synthesis Report
    Project No. TREN-05-FP6TR-S07.61320-518404-DRUID DRUID Driving under the Influence of Drugs, Alcohol and Medicines Integrated Project 1.6. Sustainable Development, Global Change and Ecosystem 1.6.2: Sustainable Surface Transport 6th Framework Programme Deliverable 4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Due date of deliverable: 21.07.2011 Actual submission date: 21.07.2011 Revision date: 21.07.2011 Start date of project: 15.10.2006 Duration: 48 months Organisation name of lead contractor for this deliverable: UVA Revision 0.0 Project co-funded by the European Commission within the Sixth Framework Programme (2002-2006) Dissemination Level PU Public PP Restricted to other programme participants (including the Commission x Services) RE Restricted to a group specified by the consortium (including the Commission Services) CO Confidential, only for members of the consortium (including the Commission Services) DRUID 6th Framework Programme Deliverable D.4.4.1 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Page 1 of 243 Classification of medicinal drugs and driving: Co-ordination and synthesis report. Authors Trinidad Gómez-Talegón, Inmaculada Fierro, M. Carmen Del Río, F. Javier Álvarez (UVa, University of Valladolid, Spain) Partners - Silvia Ravera, Susana Monteiro, Han de Gier (RUGPha, University of Groningen, the Netherlands) - Gertrude Van der Linden, Sara-Ann Legrand, Kristof Pil, Alain Verstraete (UGent, Ghent University, Belgium) - Michel Mallaret, Charles Mercier-Guyon, Isabelle Mercier-Guyon (UGren, University of Grenoble, Centre Regional de Pharmacovigilance, France) - Katerina Touliou (CERT-HIT, Centre for Research and Technology Hellas, Greece) - Michael Hei βing (BASt, Bundesanstalt für Straßenwesen, Germany).
    [Show full text]
  • PHARMACEUTICAL APPENDIX to the TARIFF SCHEDULE 2 Table 1
    Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2020) Revision 19 Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names INN which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service CAS registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known.
    [Show full text]
  • Treatment of Pulmonary Hypertension with Carbonic Anhydrase Inhibitors in Combination with a Sympathomimetic Amine
    (19) TZZ _Z9B_T (11) EP 2 167 099 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61K 31/7048 (2006.01) A61K 31/137 (2006.01) 17.10.2012 Bulletin 2012/42 A61K 31/423 (2006.01) A61K 31/433 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01) (2006.01) (21) Application number: 08767969.2 A61P 11/00 (22) Date of filing: 30.05.2008 (86) International application number: PCT/US2008/006850 (87) International publication number: WO 2008/156550 (24.12.2008 Gazette 2008/52) (54) TREATMENT OF PULMONARY HYPERTENSION WITH CARBONIC ANHYDRASE INHIBITORS IN COMBINATION WITH A SYMPATHOMIMETIC AMINE BEHANLDUNG VON PULMONALER HYPERTONIE MIT CARBONSÄUREANHYDRASE- INHIBITOREN IN KOMBINATION MIT EINEM SYMPATHOMIMETISCHEN AMIN TRAITEMENT DE L’HYPERTENSION PULMONAIRE AVEC DES INHIBITEURS DE L’ANHYDRASE CARBONIQUE (84) Designated Contracting States: •TAM,Peter AT BE BG CH CY CZ DE DK EE ES FI FR GB GR Redwood City, CA 94061 (US) HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT • WILSON, Leland RO SE SI SK TR Menlo Park, CA 94025 (US) • PETERSON, Craig (30) Priority: 13.06.2007 US 818306 Mountain View, CA 94040 (US) (43) Date of publication of application: (74) Representative: Finnie, Isobel Lara et al 31.03.2010 Bulletin 2010/13 Mintz Levin Cohn Ferris Glovsky and Popeo Intellectual Property LLP (60) Divisional application: Alder Castle 12172276.3 / 2 500 024 10 Noble Street London (73) Proprietor: Vivus, Inc. EC2V 7JX (GB) Mountain View, CA 94040 (US) (56) References cited: (72) Inventors: WO-A-00/76493 WO-A-2006/063078 • NAJARIAN, Thomas WO-A-2007/084290 WO-A-2008/060963 Los Osos, CA 93402 (US) Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations.
    [Show full text]
  • Partial Agreement in the Social and Public Health Field
    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
    [Show full text]
  • Extension of an Existing Screening Method for Diuretics with Beta- Blocking Agents
    In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (13). Sport und Buch Strauß - Köln 2005 K. Deventer, P. Van Eenoo, F.T. Delbeke Extension of an existing screening method for diuretics with beta- blocking agents Doping Control Laboratory (DoCoLab), Ghent University-UGent, Technologiepark 30B, B-9052 Zwijnaarde, Belgium 1. Introduction At the beginning of 2004 WADA took over the fight against doping from the IOC. The existing list of prohibited compounds was re-evaluated thouroughly. New compounds were added to the list1 . One group of compounds which was extended are the beta-blocking agents. It was evident to include these new beta-blockers in the existing GC/MS-screening method for beta-blocking agents2-3 (screening II) However problems with derivatization occured and therefore the detection by LC/MS has been investigated resulting in a highly sensitive method 4. The aim of this study was to include the beta-blockers in the existing LC/MS screening method for diuretics5. 2. Experimental 2.1. Chemicals and reagents The origin and suppliers of the diuretics have been previously described5. Beta-blockers obtained as reference substances were: acebutolol from Rhone-Poulenc (Brussels), alprenolol from Astra Chemicals (Holstein, Germany), atenolol and propranolol from ICI (Kortenberg, Belgium), betaxolol from Synthelabo (Brussels), labetolol from Glaxo (Brussels), 21 In: W Schänzer, H Geyer, A Gotzmann, U Mareck (eds.) Recent Advances In Doping Analysis (13). Sport und Buch Strauß - Köln 2005 metoprolol from Ciba-Geigy (Groot-Bijgaarden), nadolol from Squibb (Braine l'Alleud, Belgium), oxprenolol from CIBA (Dilbeek, Belgium), pindolol from Sandoz (Vilvoorde, Belgium), sotalol from Pfizer (Brussels), timolol from MSD (Brussels), penbutolol from Thomson (London, United Kingdom), bisoprolol from Merck, mepindolol from Schering ( Machelen, Belgium) and carvedilol from Roche (Mannheim, Germany).
    [Show full text]
  • Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
    20558 Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DEPARMENT OF THE TREASURY Services, U.S. Customs Service, 1301 TABLE 1.ÐPHARMACEUTICAL APPEN- Constitution Avenue NW, Washington, DIX TO THE HTSUSÐContinued Customs Service D.C. 20229 at (202) 927±1060. CAS No. Pharmaceutical [T.D. 95±33] Dated: April 14, 1995. 52±78±8 ..................... NORETHANDROLONE. A. W. Tennant, 52±86±8 ..................... HALOPERIDOL. Pharmaceutical Tables 1 and 3 of the Director, Office of Laboratories and Scientific 52±88±0 ..................... ATROPINE METHONITRATE. HTSUS 52±90±4 ..................... CYSTEINE. Services. 53±03±2 ..................... PREDNISONE. 53±06±5 ..................... CORTISONE. AGENCY: Customs Service, Department TABLE 1.ÐPHARMACEUTICAL 53±10±1 ..................... HYDROXYDIONE SODIUM SUCCI- of the Treasury. NATE. APPENDIX TO THE HTSUS 53±16±7 ..................... ESTRONE. ACTION: Listing of the products found in 53±18±9 ..................... BIETASERPINE. Table 1 and Table 3 of the CAS No. Pharmaceutical 53±19±0 ..................... MITOTANE. 53±31±6 ..................... MEDIBAZINE. Pharmaceutical Appendix to the N/A ............................. ACTAGARDIN. 53±33±8 ..................... PARAMETHASONE. Harmonized Tariff Schedule of the N/A ............................. ARDACIN. 53±34±9 ..................... FLUPREDNISOLONE. N/A ............................. BICIROMAB. 53±39±4 ..................... OXANDROLONE. United States of America in Chemical N/A ............................. CELUCLORAL. 53±43±0
    [Show full text]
  • Carbonic Anhydrase Inhibitors (Systemic)/DIAMOX/ACETAZOLAMIDE/METHAZOLAMIDE
    Carbonic Anhydrase Inhibitors (Systemic)/DIAMOX/ACETAZOLAMIDE/METHAZOLAMIDE For quick reference, the following carbonic anhydrase inhibitors are numbered to match the Note: corresponding brand names. Another commonly used name for dichlorphenamide is diclofenamide. Category • Altitude sickness, acute, prophylactic and therapeutic agent --Acetazolamide • Anticonvulsant --Acetazolamide • Antiglaucoma agent, systemic -- Acetazolamide; Dichlorphenamide; Methazolamide • Antiparalytic, familial periodic paralysis --Acetazolamide • Antiurolithic, cystine calculi --Acetazolamide • Antiurolithic, uric acid calculi --Acetazolamide • Diuretic, urinary alkalinizing -- Acetazolamide Description Carbonic anhydrase inhibitors are used to treat glaucoma. Acetazolamide is also used as an anticonvulsant to control certain seizures in the treatment of epilepsy. It is also sometimes used to prevent or lessen some effects in mountain climbers who climb to high altitudes, and to treat other conditions as determined by your doctor. These medicines are available only with your doctor's prescription, in the following dosage forms: Oral • Acetazolamide /Dichlorphenam/ Methazolamide Before Using This Medicine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For carbonic anhydrase inhibitors, the following should be considered: Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to carbonic anhydrase inhibitors, sulfonamides (sulfa drugs), or thiazide diuretics (a type of water pill). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Pregnancy—Carbonic anhydrase inhibitors have not been studied in pregnant women. However, studies in animals have shown that carbonic anhydrase inhibitors cause birth defects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.
    [Show full text]
  • Reseptregisteret 2014–2018 the Norwegian Prescription Database 2014–2018
    LEGEMIDDELSTATISTIKK 2019:2 Reseptregisteret 2014–2018 The Norwegian Prescription Database 2014–2018 Reseptregisteret 2014–2018 The Norwegian Prescription Database 2014–2018 Christian Lie Berg Kristine Olsen Solveig Sakshaug Utgitt av Folkehelseinstituttet / Published by Norwegian Institute of Public Health Område for Helsedata og digitalisering Avdeling for Legemiddelstatistikk Juni 2019 Tittel/Title: Legemiddelstatistikk 2019:2 Reseptregisteret 2014–2018 / The Norwegian Prescription Database 2014–2018 Forfattere/Authors: Christian Berg, redaktør/editor Kristine Olsen Solveig Sakshaug Acknowledgement: Julie D. W. Johansen (English text) Bestilling/Order: Rapporten kan lastes ned som pdf på Folkehelseinstituttets nettsider: www.fhi.no / The report can be downloaded from www.fhi.no Grafisk design omslag: Fete Typer Ombrekking: Houston911 Kontaktinformasjon / Contact information: Folkehelseinstituttet / Norwegian Institute of Public Health Postboks 222 Skøyen N-0213 Oslo Tel: +47 21 07 70 00 ISSN: 1890-9647 ISBN: 978-82-8406-014-9 Sitering/Citation: Berg, C (red), Reseptregisteret 2014–2018 [The Norwegian Prescription Database 2014–2018] Legemiddelstatistikk 2019:2, Oslo, Norge: Folkehelseinstituttet, 2019. Tidligere utgaver / Previous editions: 2008: Reseptregisteret 2004–2007 / The Norwegian Prescription Database 2004–2007 2009: Legemiddelstatistikk 2009:2: Reseptregisteret 2004–2008 / The Norwegian Prescription Database 2004–2008 2010: Legemiddelstatistikk 2010:2: Reseptregisteret 2005–2009. Tema: Vanedannende legemidler / The Norwegian
    [Show full text]
  • Drug/Substance Trade Name(S)
    A B C D E F G H I J K 1 Drug/Substance Trade Name(s) Drug Class Existing Penalty Class Special Notation T1:Doping/Endangerment Level T2: Mismanagement Level Comments Methylenedioxypyrovalerone is a stimulant of the cathinone class which acts as a 3,4-methylenedioxypyprovaleroneMDPV, “bath salts” norepinephrine-dopamine reuptake inhibitor. It was first developed in the 1960s by a team at 1 A Yes A A 2 Boehringer Ingelheim. No 3 Alfentanil Alfenta Narcotic used to control pain and keep patients asleep during surgery. 1 A Yes A No A Aminoxafen, Aminorex is a weight loss stimulant drug. It was withdrawn from the market after it was found Aminorex Aminoxaphen, Apiquel, to cause pulmonary hypertension. 1 A Yes A A 4 McN-742, Menocil No Amphetamine is a potent central nervous system stimulant that is used in the treatment of Amphetamine Speed, Upper 1 A Yes A A 5 attention deficit hyperactivity disorder, narcolepsy, and obesity. No Anileridine is a synthetic analgesic drug and is a member of the piperidine class of analgesic Anileridine Leritine 1 A Yes A A 6 agents developed by Merck & Co. in the 1950s. No Dopamine promoter used to treat loss of muscle movement control caused by Parkinson's Apomorphine Apokyn, Ixense 1 A Yes A A 7 disease. No Recreational drug with euphoriant and stimulant properties. The effects produced by BZP are comparable to those produced by amphetamine. It is often claimed that BZP was originally Benzylpiperazine BZP 1 A Yes A A synthesized as a potential antihelminthic (anti-parasitic) agent for use in farm animals.
    [Show full text]
  • In Vitro and in Vivo Activities of the Carbonic Anhydrase Inhibitor, Dorzolamide, Against Vancomycin-Resistant Enterococci
    In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci Nader S. Abutaleb1,2, Ahmed E.M. Elhassanny1, Daniel P. Flaherty3,4 and Mohamed N. Seleem1,2 1 Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA, United States of America 2 Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States of America 3 Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, United States of America 4 Purdue Institute for Drug Discovery, Purdue University, West Lafayette, IN, United States of America ABSTRACT Vancomycin-resistant enterococci (VRE) are a serious public health threat and a leading cause of healthcare-associated infections. Bacterial resistance to antibiotics recom- mended for the treatment of enterococcal infections complicates the management of these infections. Hence, there is a critical need for the discovery of new anti-VRE agents. We previously reported carbonic anhydrase inhibitors (CAIs) as new potent VRE inhibitors. In the present study, the activity of the CAI, dorzolamide was evaluated against VRE both in vitro and in vivo. Dorzolamide exhibited potent activity against a panel of clinical VRE isolates, with minimum inhibitory concentration (MIC) values ranging from 1 mg/mL to 8 mg/mL. A killing kinetics experiment determined that dorzolamide exhibited a bacteriostatic effect against VRE, which was similar to the drug of choice (linezolid). Dorzolamide interacted synergistically with gentamicin against four strains of VRE, and exhibited an additive interaction with gentamicin against six VRE strains, reducing gentamicin's MIC by several folds.
    [Show full text]
  • New-Drug-Classificat
    FOOD AND DRUGS BOARD REVIEWED DRUG CLASSIFICATION LIST PRESCRIPTION ONLY MEDICINES (POM) The salts, preparations and admixture of the following; Acarbose Acebutolol Acetazolamide Acetohexamide Acetylcysteine Acetyldigitoxin Acetyldihydrocodeine Actinomycin-D Acyclovir (preparations containing more than 5 %) Aescin, other than preparations intended for topical use only Aceclofenac Alcuronium Alfadolonum Alfaxalonum Alfentanil Alfuzosin Allergy desensitization treatment sets, in graded doses Allopurinol Alprazolam, CD Alprostadil Alseroxylon Altretamine Amantadine Amineptine Aminocaproic acid Amitriptyline Amlodipine Amoxapine Amphotericin (except in lozenges) Anaesthetic agents, including local anaesthetics intended for injection, but excluding those preparations intended for topical use and procaine for oral use Anastrozole Antibacterial substances, including any preparations and admixtures, other than the following- a. eye ointments containing 1% tetracycline or oxytetracycline which are for use in Trachoma b. Chloramphenicol eye preparations Antimony Arteether (beta alfa) injection Artemether and its derivatives Atazanavir Atenolol Atracurium Azacyclonal Azathioprine Azapropazone Azithromycin Baclofen Barbituric acid, other than preparations containing 15mg or less in combination with other drugs per unit dose Beclomethasone Bemagride Benztropine Benzydamine Betahistine Betamethasone Betaxolol Bicalutamide Bimatoprost Bisoprolol Brimonidine Brinzolamide Bromazepam, CD Bromocriptine Bromvaletone Brucine Budesonide Buccal insulin preparations
    [Show full text]
  • Pharmacological Drugs Inducing Ototoxicity, Vestibular Symptoms and Tinnitus: a Reasoned and Updated Guide
    European Review for Medical and Pharmacological Sciences 2011; 15: 601-636 Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: a reasoned and updated guide G. CIANFRONE1, D. PENTANGELO1, F. CIANFRONE2, F. MAZZEI1, R. TURCHETTA1, M.P. ORLANDO1, G. ALTISSIMI1 1Department of Otolaryngology, Audiology and Phoniatrics, “Umberto I” University Hospital, Sapienza University, Rome (Italy); 2Institute of Otorhinolaryngology, School of Medicine, Catholic University of the Sacred Heart, Rome (Italy) Abstract. – The present work on drug-in- Introduction duced ototoxicity, tinnitus and vertigo repre- sents the update and revision of a previous The panorama of the pharmacological origin guide to adverse drug reactions for italian physi- iatrogenic noxae able to induce either harmful cians (2005). The panorama of drug-induced side effects causing ototoxicity or symptoms ototoxic effects or just a symptomatology like tin- such as tinnitus or dizziness and vertigo has en- nitus or balance disturbances, without any harm- larged in recent years, thanks to a better knowl- ful consequence, has widened in the last few edge and a more specific attention of pharma- years. The reason for this is the progress of scien- ceutical firms and drug-control institutions. In tific knowledge, the increased awareness of the daily clinical practice, there is a need for the pharmaceutical companies and of the institutions, family physician and the ENT specialist or audi- ologist (also in consideration of the possible which supervise pharmaceutical production. medico-legal implications) to focus the attention Only through continuous updating and experi- on the possible risk of otological side effects. ence sharing it’s possible to offer patients the This would allow a clinical risk-benefit evalua- certainty of receiving the treatment that is appro- tion, weighing the possible clinical advantage in priate, safe and effective and based upon the their field of competence against possible oto- most credited clinical studies.
    [Show full text]