DOCSLIB.ORG

LAWS of MINNESOTA for 1987 16

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
LAWS of MINNESOTA for 1987 16 A Ch. 13 LAWS of MINNESOTA for 1987 16 954.93 ggl central angle o_f Q degrees minutes 42 seconds 33; a_ fl for g distance o_f 1497.42 _fe_et; thence North 9 degrees Q8 minutes seconds distance 691.02 thence along tangen- _3_3_~ E_as;t fir i_i o_f E‘, 9 right 1145.92 distance t_igl curve th_e having radius @ Q a_1 39 g 9_f o_f 348.41 fgg 19 g 1% Q th_e north Iii gfsiig Northwest Quar- te_r being 808.61 £e_et eit 91‘ the northwest corner o_f @ Section g M there terminating. Except that part o_f E existing Lexington Avenue right o_f way; containing 2.4702 acres, more gr less. See. 3. EFFECTIVE DATE. This a_ct Q effective Q63 Qty after compliance with Minnesota Statutes, section 645.021, subdivision 35 by ’th_e board o_f Ramsey county commissioners. Approved March 27, 1987 CHAPTER 14—H.F.No. 688 An act relating to controlled substances; classifying the substance alfentanil as a sched- ule II controlled substance; amending Minnesota Statutes 1986, section 152.02, subdivision 3. BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF MINNESOTA: Section 1. Minnesota Statutes 1986, section 152.02, subdivision 3, is amended to read: Subd. 3. The following items are listed in Schedule II: (1) Unless specifically excepted or unless listed in another schedule, any of the following substances whether produced directly or indirectly by extraction from substances of vegetable origin or independently by means of chemical synthesis, or by a combination of extraction and chemical synthesis: (a) Opium and opiate, and any salt, compound, derivative, or preparation of opium or opiate, including the following: raw opium, opium extracts, opium fluidextracts, powdered opium, granulated opium, tincture of opium, apomor- phine, codeine, ethylmorphine, hydrocodone, hydromorphone, metopon, mor- phine, oxycodone, oxymorphone, thebaine. (b) Any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of the substances referred to in clause (a), except that these substances shall not include the isoquinoline alkaloids of opium. (c) Opium poppy and poppy straw. Changes or additions are indicated by underline, deletions by Copyright © 1987 by the Office of the Revisor of Statutes, State of Minnesota. All Rights Reserved. 17 LAWS of MINNESOTA for 1987 Ch. 14 derivative, preparation oi‘ ((1) Coca leaves and any salt, compound, or coca leaves, and any salt, compound, derivative, or preparation thereof which is chemically equivalent or identical with any of these substances, except that the substances shall not include decocainized coca leaves or extraction of coca leaves, which extractions do not contain cocaine or ecgonine. (2) Any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters and ethers, unless specifically excepted, or unless listed in another schedule, whenever the existence of such isomers, esters, ethers and salts is possible within the specific chemical designation: Alfentanil Alpha- prodine; Anileridineg Bezitramide; Dihydrocodeine; Dihydromorphinone; Diphen- oxylate; Fentanyl; Isomethadone; Levomethorphan; Levorphanol; Metazocine; Methadone; Methadone - Intermediate, 4-cyano-2-dimethylamino-4, 4-diphenyl- butane; Moramide - Intermediate, 2-methyl-3-morpholino-l, l-diphenyl-propane- carboxylic acid; Pethidine; Pethidine - Intermediate - A, 4-cyano-l-methy1—4- phenylpiperidine; Pethidine - Intermediate - B, ethyl-4-phenylpiperidine-4-car- boxylate; Pethidine - Intermediate ~ C, 1-methyl-4—phenylpiperidine—4—carboxylic acid; Phenazocine; Piminodine; Racemethorphan; Racemorphan. (3) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a stimulant efi"ect on the central nervous system: (a) Amphetamine, its salts, optical isomers, and salts of its optical isomers; (b) Methamphetamine, its salts, isomers, and salts of its isomers; (c) Phenmetrazine and its salts; (d) Methylphenidate. (4) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation which contains any quantity of the following substances having a depressant effect on the central nervous system, including its salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical desig- nation: (a) Methaqualonc (b) Amobarbital (c) Secobarbital (d) Pentobarbital (e) Phencyclidine (i) Phencyclidine immediate precursors: (i) 1—phenylcyclohexylamine Changes or additions are indicated by underline, deletions by stsileeeut. Copyright © 1987 by the Office of the Revisor of Statutes, State of Minnesota. All Rights Reserved. Ch. 14 LAWS of MINNESOTA for 1987 18 (ii) 1—piperidinocyclohexanecarbonitrile. Sec. 2. EFFECTIVE DATE. following enactment. 1 i_s e_fi"__e_g1i_‘_/p 33 _d_ay f1_r_1_al Approved March 27, 1987 CHAPTER 15—H.F.N0. 1 An act relating to agriculture; extending and financing the interest rate buy-down program; establishing benefit limits; appropriating money; amending Laws 1986, chapter ‘ 398, article 23, section 4, by adding a subdivision. BE IT ENACTED BY THE LEGISLATURE OF THE STATE OF MINNESOTA: FARM OPERATING LOAN INTEREST BUY-DOWN PROGRAM. Section 1. DEFINITIONS. Subdivision L APPLICABILITY. [lg definitions ip iis section apply _tp sections I Q 1 £1 Q; :I‘_l§ definitions i_n @ section Q apply t_o sections § unless different definition provided section g_r_1_c_l 2 e_1 § i_n g Subd. Q; APPROVED ADULT FARIVI MANAGEMENT PROGRAM. “Approved adult farm management program” means g farm management train- farming been i_ng program designed Q persons currently engaged ir_1 E figs 'approved subdivision py t_l1§ commissioner under section 5, ; “Commissioner” Subd. 3. COMMISSIONER. means t_h__e commissioner o_f COIIIITIGICC. COMMISSIONER’S INTEREST INDEX. “Commissioner’s Subd. :l_. Q index” terest means Q interest ra_te th_at i_s ;; percent above me current lending rfl 9_f1l;§ Federal Intermediate Credit Bank t_o production credit associations Q certified month py fl1_6_: commissioner. Subd. 5. ELIGIBLE BORROWER. “Eligible borrower” means g farmer who applies lender farm operating loan meets Qualifications t_o z_1 E Q E1 a_ll established _ip section 2 Qt} a_ny further gualifications that may Q established ip ’ch_e guidelines adopted by pile commissioner under section 3, subdivision L eligible borrower must complete loan application with participating Q a_ Q lender between January I, 1987, §n_<i December 114 1987. Subd. Q FARM OPERATING LOAN. “Farm operating loan” means gr renegotiated loan credit obtained farmer original; extended, o_r Q HE pf pg §._ financing operations farm. farm from 3 lender [cg flip purpose o_f E pf _a A Changes or additions are indicated by underline, deletions by str-i-leeeut. Copyright © 1987 by the Office of the Revisor of Statutes, State of Minnesota. All Rights Reserved. .
Load more

Recommended publications
  • (19) United States (12) Patent Application Publication (10) Pub
    US 20050181041A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0181041 A1 Goldman (43) Pub. Date: Aug. 18, 2005 (54) METHOD OF PREPARATION OF MIXED Related US. Application Data PHASE CO-CRYSTALS WITH ACTIVE AGENTS (60) Provisional application No. 60/528,232, ?led on Dec. 9, 2003. Provisional application No. 60/559,862, ?led (75) Inventor: David Goldman, Portland, CT (US) on Apr. 6, 2004. Correspondence Address: Publication Classi?cation LEYDIG VOIT & MAYER, LTD (51) Int. Cl.7 ....................... .. A61K 31/56; A61K 38/00; TWO PRUDENTIAL PLAZA, SUITE 4900 A61K 9/64 180 NORTH STETSON AVENUE (52) US. Cl. ............................ .. 424/456; 514/179; 514/2; CHICAGO, IL 60601-6780 (US) 514/221 (73) Assignee: MedCrystalForms, LLC, Hunt Valley, (57) ABSTRACT MD This invention pertains to a method of preparing mixed phase co-crystals of active agents With one or more materials (21) Appl. No.: 11/008,034 that alloWs the modi?cation of the active agent to a neW physical/crystal form With unique properties useful for the delivery of the active agent, as Well as compositions com (22) Filed: Dec. 9, 2004 prising the mixed phase co-crystals. Patent Application Publication Aug. 18, 2005 Sheet 1 0f 8 US 2005/0181041 A1 FIG. 1a 214.70°C z.m."m.n... 206.98°C n..0ao 142 OJ/g as:20m=3: -0.8 -1.0 40 90 1:10 2110 Temperture (°C) FIG. 1b 0.01 as:22“.Km: 217 095 24221.4 39Jmum/Q -0.8 35 155 255 255 Temperture (°C) Patent Application Publication Aug.
    [Show full text]
  • Measures and CDS for Safer Opioid Prescribing: a Literature Review
    Measures and CDS for Safer Opioid Prescribing: A Literature Review Measures and CDS for Safer Opioid Prescribing: A Literature Review Executive Summary The U.S. opioid epidemic continues to pose significant challenges for patients, families, clinicians, and public health policy. Opioids are responsible for an estimated 315,000 deaths (from 1999 to 2016) and have caused 115 deaths per day.1 In 2017, the U.S. Department of Health and Human Services declared the opioid epidemic a public health crisis.2 The total economic burden of opioid abuse in the United States has been estimated to be $78.5 billion per year.3 Although providing care for chronic opioid users is important, equally vital are efforts to prevent so-called opioid-naïve patients (patients with no history of opioid use) from developing regular opioid use, misuse, or abuse. However, much remains unclear regarding what role clinician prescribing habits play and what duration or dose of opioids may safely be prescribed without promoting long-term use.4,5 In 2013, ECRI Institute convened the Partnership for Health IT Patient Safety, and its component, single-topic-focused workgroups followed. For this subject, the Electronic Health Record Association (EHRA): Measures and Clinical Decision Support (CDS) for Safer Opioid Prescribing workgroup included members from the Healthcare Information and Management Systems Society (HIMSS) EHRA and the Partnership team. The project was oriented towards exploring methods to enable a synergistic cycle of performance measurement and identifying electronic health record (EHR)/health information technology (IT)–enabled approaches to support healthcare organizations’ ability to assess and measure opioid prescribing.
    [Show full text]
  • Thesis, Stereochemistry and Structure-Activity Relationship of Opioid Ligands Related to 4-Aryl-1-Methylpiperidines and Phencyclidine
    University of Bath PHD On the investigation of the synthesis, stereochemistry and structure-activity relationship of opioid ligands related to 4-aryl-1-methylpiperidines and phencyclidine Al-Deeb, Omar A. A. Award date: 1989 Awarding institution: University of Bath Link to publication Alternative formats If you require this document in an alternative format, please contact: [email protected] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 07. Oct. 2021 IN THE NAME OF. ALLAH THE MERCIFUL THE COMPASSIONATE ON THE INVESTIGATION OF THE SYNTHESIS, STEREOCHEMISTRY AND STRUCTURE-ACTIVITY RELATIONSHIP OF OPIOID LIGANDS RELATED TO 4-ARYL-l-METHYLPIPERIDINES AND PHENCYCLIDINE Thesis Submitted by OMAR A.A. AL-DEEB, B.SC., M.So., for the degree of Doctor of Philosophy of the University of Bath 1989 This research has been carried out in the School of Pharmacy and Pharmacology under the supervision of Dr.
    [Show full text]
  • Thesis Rests with the Author
    University of Bath PHD Stereochemical studies of narcotic analgesics related to pethidine and fentanyl. Ogungbamila, Francis Omoseyin Award date: 1982 Awarding institution: University of Bath Link to publication Alternative formats If you require this document in an alternative format, please contact: [email protected] General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 07. Oct. 2021 STEREOCHEMICAL STUDIES OF NARCOTIC ANALGESICS RELATED TO PETHIDINE AND FENTANYL. Submitted by FRANCIS OMOSEYIN OGUNGBAMILA for the degree of Doctor of Philosophy of the University of Bath, 1982. This research has been carried out in the School of Pharmacy and Pharmacology of the University of Bath, under the supervision of Dr. A.F. Casy, D.Sc., Ph.D., F.P.S., C.Chem., F .R.S.C. COPYRIGHT. Attention is drawn to the fact that copyright of this thesis rests with the author.
    [Show full text]
  • ATP, 489 Absolute Configuration Benzomotphans, 204 Levotphanol
    Index AIDA, 495 Affinity labeling, analogs of (Cont.) cAMP, 409, 489 motphine,448 ATP, 409, 489 naltrexone, 449 [3H] ATP, 489 norlevotphanol,449 Absolute configuration normetazocine, 181 benzomotphans, 204 norpethidine, 232 levotphanol, 115 oripavine, 453 methadone and analogs, 316 oxymotphone, 449 motphine, 86 K-Agonists, 179,405,434 phenoperidine, 234 Aid in Interactive Drug Analysis, 495 piperazine derivatives, 399 [L-Ala2] dermotphin, 363 prodines and analogs, 272 [D-Ala, D-Leu] enkephalin (DADL), 68, 344 sinomenine, 28, 115 [D-Ala2 , Bugs] enkephalinamide, 347, 447 viminol, 400 [D-Ala2, Met'] enkephalinamide, 337, 346, Ac 61-91,360 371,489 Acetylcholine, 5, 407 [D-Ala2]leu-enkephalin, 344, 346, 348 Acetylcholine analogs, 186, 191 [D-Ala2] met-enkephalin, 348 l-Acetylcodeine, 32 [D-Ala2] enkephalins, 347 Acetylmethadols (a and (3) Alfentanil, 296 maintenance of addicts by a-isomer, 304, 309 (±)-I1(3-Alkylbenzomotphans, 167, 170 metabolism, 309 11(3-Alkylbenzomotphans, 204 N-allyl and N-CPM analogs, 310, 431 7-Alkylisomotphinans, 146 stereochemistry, 323 N-Alkylnorketobemidones, 431 synthesis, 309 N-Alkylnorpethidines, 233 X-ray crystallography, 327 N-Allylnormetazocine, 420 6-Acetylmotphine, receptor binding, 27 N-Allylnormotphine, 405 Acetylnormethadol, 323 N-Allylnorpethidine, 233 8(3-Acyldihydrocodeinones, 52 3-Allylprodines (a and (3), 256 14-Acyl-4,5-epoxymotphinans, 58 'H-NMR and stereochemistry, 256 7-Acylhydromotphones, 128 X-ray crystallography, 256 Addiction, 4 N-Allylnormetazocine, 420 Adenylate cyclase, 6, 409, 413, 424,
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2016/0317530 A1 Sandhu Et Al
    US 20160317530A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2016/0317530 A1 Sandhu et al. (43) Pub. Date: Nov. 3, 2016 (54) ABUSE-RESISTANT DRUG FORMULATIONS Publication Classification (71) Applicant: KASHIV PHARMA, LLC, (51) Int. Cl. Bridgewater, NJ (US) A63L/485 (2006.01) A63L/35 (2006.01) (72) Inventors: Harpreet Kaur Sandhu, West Orange, A6II 47/22 (2006.01) NJ (US); Siva Ram Kiran Vaka, A6II 47/8 (2006.01) Piscataway, NJ (US); Ashish Chatterji, A6II 47/10 (2006.01) East Brunswick, NJ (US); Dipen Desai, A6II 47/4 (2006.01) Whippany, NJ (US); Wantanee A6II 47/02 (2006.01) Phuapradit, Montville, NJ (US); A6II 47/44 (2006.01) Navnit H. Shah, Clifton, NJ (US) A6II 3/167 (2006.01) A6II 47/20 (2006.01) (52) U.S. Cl. (73) Assignee: Kashiv Pharma, LLC, Bridgewater, NJ CPC ........... A61K 31/485 (2013.01); A61K 3 1/167 (US) (2013.01); A61K 31/135 (2013.01); A61 K 47/22 (2013.01); A61K 47/20 (2013.01); A61 K (21) Appl. No.: 15/108,157 47/10 (2013.01); A61K 47/14 (2013.01); A61 K 47/02 (2013.01); A61K 47/44 (2013.01); A61 K (22) PCT Fed: Dec. 31, 2014 47/18 (2013.01) (86) PCT No.: PCT/US2O14/072968 (57) ABSTRACT Disclosed are abuse resistant oral pharmaceutical composi S 371 (c)(1), tions that reduce the likelihood of improper administration (2) Date: Jun. 24, 2016 of drugs that are susceptible to abuse. The oral pharmaceu tical formulations contain abuse deterrent agents that cause discomfort to the user when administered in an improper Related U.S.
    [Show full text]
  • Chapter 152 Minnesota Statutes 1974
    MINNESOTA STATUTES 1974 2111 PROHIBITED DRUGS 152.01 CHAPTER 152 PROHIBITED DRUGS Sec. Sec. 152.01 Definitions 152.12 Doctors may prescribe 152.02 Schedules of controlled substances; admin­ 152.13 Duties of state board of pharmacy istration of chapter 152.15 Violations; penalties 152.09 Prohibited acts 152.18 Discharge and dismissal 152.10 Sales, persons eligible 152.19 Forfeitures 152.101 Manufacturers, records 152.20 Penalties under other laws 152.11 Written or oral prescriptions, requisites 152.01 DEFINITIONS. Subdivision 1. Words, terms, and phrases. Unless the language or context clearly indicates that a different meaning is intended, the fol­ lowing words, terms, and phrases, for the purposes of this chapter, shall be given the meanings subjoined to them. Subd. 2. Drug. The term "drug" includes all medicines and preparations recognized in the United States pharmacopoeia or national formulary and any substance or mixture of substances intended to be used for the cure, mitigation, or prevention of disease of either man or other animals. Subd. 3. M.S. 1967 [Repealed, 1969 c 933 s 22] Subd. 3. Administer. "Administer" means to deliver by, or pursuant to the lawful order of a practitioner a single dose of a controlled substance to a patient or research subject by injection, inhalation, ingestion, or by any other immediate means. Subd. 4. M.S. 1967 [Repealed, 1969 c 933 s 22] Subd. 4. Controlled substance. "Controlled substance" means a drug, sub­ stance, or immediate precursor in Schedules I through V of section 152.02. The term shall not include distilled spirits, wine, malt beverages, intoxicating liquors or tobacco.
    [Show full text]
  • Pain and Addiction Therapeutics
    The State of Innovation in Highly Prevalent Chronic Diseases Volume II: Pain and Addiction Therapeutics by David Thomas, CFA and Chad Wessel BIO INDUSTRY ANALYSIS February 2018 Introduction The following report is the second in a series on the current funding and R&D landscape of highly prevalent, chronic diseases. In our previously published research, emerging company investment for drug development in many of these common diseases was shown to be declining over the last decade and low relative to the prevalence and cost of these diseases (Figure 1).1 The persistence of this trend could have implications for the future output of innovative medicines in these disease areas. The cause for concern is magnified by the impact these chronic disease areas are having on the overall healthcare system in the US. Thus, it is important that barriers to therapeutic innovation are identified and removed. This volume takes an in depth look at the state of innovation in pain as well as addiction therapeutics. Chronic pain affects as many as 100 million people in the US alone.2 Total economic and direct healthcare costs for treating pain in the US have been estimated to be as high as $635 billion annually, higher than the costs for cancer, Alzheimer’s, or cardiovascular disease.3 Addiction to drugs and alcohol affects more than 23 million Americans and continues to rise, in part due to abuses of pain medications.4 Total economic and direct healthcare costs for substance abuse is an alarming $700 billion per year.5 Herein, we analyze all drugs marketed in the US for pain and addiction, as well as potential future drugs that are progressing through the clinical pipeline to meet the urgent needs of patients.
    [Show full text]
  • Committee on Energy and Commerce U.S. House of Representatives Witness Disclosure Requirement - "Truth in Testimony" Required by House Rule XI, Clause 2(G)(5)
    Committee on Energy and Commerce U.S. House of Representatives Witness Disclosure Requirement - "Truth in Testimony" Required by House Rule XI, Clause 2(g)(5) 1. Your Name: Patrick M. Beardsley, Ph.D. 2. Your Title: Professor, Pharmacology and Toxicology 3. The Entity(ies) You are Representing: Self; selected by American Society for Pharmacology and Experimental Therapeutics 4. Are you testifying on behalf of the Federal, or a State or local Yes No government entity? x Please list any Federal grants or contracts, or contracts or payments originating with a foreign government, that you or the entity(ies) you represent have received on or after January 1, 2015. Only grants, contracts, or payments related to the subject matter of the hearing must be listed. 1. Beardsley, P. M., (PI) (2017-2022). Preclinical medications discovery and abuse liability testing for the National Institute on Drug Abuse. $4,318,971. $7,607,514 (Ultimate Contract Value (Base Period, Option Periods, and Option Quantities), National Institute on Drug Abuse. 2. Beardsley, P. M. (PI) (2017). Analgesia studies: Solicitation number: D-17-OD-0092, Drug Enforcement Agency. $149,040. 3. Beardsley, P. M., (PI) (2014). Medication discovery using rat models of relapse. $2,954,759. $4,496,997 (Ultimate Contract Value (Base Period, Option Periods, and Option Quantities), National Institute on Drug Abuse. 1. Please attach your curriculum vitae to your completed disclosure form. Signature: _______________ ____Date:____20180228_____________ CURRICULUM VITAE PATRICK M. BEARDSLEY, Ph.D. Virginia Commonwealth University Department of Pharmacology & Toxicology, Institute for Drug and Alcohol Studies & Center for Biomarker Research and Personalized Medicine 410 N.
    [Show full text]
  • Codeine and Its Alternates for Pain and Cough Relief* 1
    Bull. Org. mond. Sante 1 1968, 38, 673-741 Bull. Wld Hlth Org. Codeine and its Alternates for Pain and Cough Relief* 1. Codeine, Exclusive of its Antitussive Action NATHAN B. EDDY, M.D.,1' HANS FRIEBEL, Dr. med.,2 KLAUS-JORGEN HAHN, Dr. med.3 & HANS HALBACH, Dr. med. Dr.-Ing.4 This report-thefirst ofa series on codeine and its alternates for pain and cough relief- presents a detailed evaluation of experimental and clinical data concerning the analgesic action of codeine (the antitussive action will be assessed separately). The authors discuss the pharmacology of the drug, including side-effects and toxicity; effects on the respiratory, circulatory, digestive and urinary systems; tolerance, dependence and liability to abuse; metabolic effects; and mechanism ofaction. Though codeine is generally more toxic than morphine to animals on account of its convulsant action, it is less toxic to man, possibly because it produces less respiratory depression. Again, tolerance to its analgesic effects has been demonstrated in several animal species, but dependence in man is observedfar less frequently than it is with morphine, and the abstinence syndrome is less intense. From their extensive review of the evidence available, the authors conclude that codeine is a good analgesic and that little risk to public health is likely to arise from its clinical use to relieve pain. CONTENTS INTRODUCTION ..... 673 EFFECT ON BLOOD ENZYMES AND OTHER ENZYME ANALGESIC ACTION . 676 SYSTEMS ..... .... ........ 707 SEDATIVE ACTION AND OTHER EFFECTS ON THE METABOLIC EFFECTS ... ...... 709 NERVOUS SYSTEM . ...... .. 693 TOXICrTy ..... ........ 710 . 695 SIDE-EFFECTS AND TOXIC REACTIONS TOLERANCE, DEPENDENCE AND ABUSE LIABILITY .
    [Show full text]
  • Problems of Drug Dependence 1998: Proceedings of the 60Th Annual Scientific Meeting the College on Problems of Drug Dependence, Inc
    National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Problems of Drug Dependence 1998: Proceedings of the 60th Annual Scientific Meeting The College on Problems of Drug Dependence, Inc. U.S. Department of Health and Human Services1 • National79 Institutes of Health Problems of Drug Dependence, 1998: Proceedings of the 66th Annual Scientific Meeting, The College on Problems of Drug Dependence, Inc. Editor: Louis S. Harris, Ph.D. Virginia Commonwealth University NIDA Research Monograph 179 1998 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Institute on Drug Abuse 6001 Executive Boulevard Bethesda, MD 20892 ACKNOWLEDGEMENT The College on Problems of Drug Dependence, Inc., an independent, non-profit organization conducts drug testing and evaluations for academic institutions, government, and industry. This monograph is based on papers or presentations from the 60th Annual Scientific Meeting of the CPDD, held in Scottsdale, Arizona, June 12-17, 1998. In the interest of rapid dissemination, it is published by the National Institute on Drug Abuse in its Research Monograph series as reviewed and submitted by the CPDD. Dr. Louis S. Harris, Department of Pharmacology and Toxicology, Virginia Commonwealth University was the editor of this monograph. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published materials as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2005/0163856A1 Maloney Et Al
    US 2005O163856A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0163856A1 Maloney et al. (43) Pub. Date: Jul. 28, 2005 (54) ABUSE-RESISTANTSUSTAINED-RELEASE Related U.S. Application Data OPOD FORMULATION (63) Continuation of application No. 10/264,020, filed on Oct. 3, 2002, which is a continuation-in-part of appli (75) Inventors: Ann Maloney, Dublin, OH (US); cation No. 10/085,597, filed on Feb. 27, 2002, now Debra Marie Murwin, Orient, OH abandoned, and which is a continuation of application (US); Michael Jay Schobelock, Grove No. 09/626,584, filed on Jul. 27, 2000, now aban City, OH (US) doned. (60) Provisional application No. 60/146,298, filed on Jul. Correspondence Address: 29, 1999. MICHAEL P. MORRIS Publication Classification BOEHRINGER INGELHEM CORPORATION 900 RIDGEBURY ROAD (51) Int. CI.7. ... A61K 31/485; A61K 9/14 PO BOX 368 (52) U.S. Cl. ............................................ 424/486; 514/282 RIDGEFIELD, CT 06877-0368 (US) (57) ABSTRACT (73) Assignee: Roxane Laboratories, Inc., Columbus, A method for reducing the abuse potential of an oral dosage OH form of an opioid extractable by commonly available house hold Solvents Said method comprising combining a thera (21) Appl. No.: 11/087,154 peutically effective amount of the opioid compound, or a Salt thereof, a matrix-forming polymer and an ionic exchange (22) Filed: Mar. 23, 2005 resin. US 2005/0163856 A1 Jul. 28, 2005 ABUSE-RESISTANTSUSTAINED-RELEASE after repeated administration of the drug, a given dose of the OPOD FORMULATION drug produces a decreased effect, or conversely, when increasingly larger doses of the drug must be administered RELATED APPLICATIONS to obtain effects observed with the original dose.
    [Show full text]