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IDIBAPS Rosselló, 149-153 08036 Barcelona

Editorial board

IDIBAPS Scientific Coordination Office

Art direction & graphic design

Marc Montalà www.marcmontala.com

Cover photo

© Irene Portolés

© IDIBAPS 2019 http://creativecommons.org/licenses/by-nc-sa/4.0/

ANNUAL

SCIENTIFIC REPORT

2018

INDEX

08 Foreword IDIBAPS

Director’s foreword About IDIBAPS Staff Research and innovation outputs Funding Institutional projects Scientific facilities Training Communication and public engagement News

56 Area 1

Biological aggression and response mechanisms

94 Area 2

Respiratory, cardiovascular and renal pathobiology and bioengineering

152 Area 3

Liver, digestive system and metabolism

218 Area 4

Clinical and experimental neuroscience

276 Area 5

Oncology and haematology

332 Transversal research groups

343

Team and group leaders index

ANNUAL

SCIENTIFIC REPORT

2018

FOREWORD IDIBAPS

© Patricia Solé

Director’s foreword

It is a great privilege and satisfaction to present in this 2018 Annual Report the activities and outstanding achievements of all the people working at IDIBAPS. Our scientific contributions are improving the understanding of the diseases we study and are changing the way we practice medicine. Our commitment to society stimulates us to spread this knowledge and these values to citizens of all ages.

From the institutional perspective, I would like to highlight the work to culminate our new strategic plan (2018-2022), which was discussed by a broad representation of the research and management communities. An analysis of the current situation of biomedical research and the social and scientific challenges that we all face have led us to define the strategic objectives and actions that will serve as a roadmap for addressing the complex situation in which we work. Major effort will be dedicated to consolidating and improving excellence in translational research, attracting and retaining talent, particularly with the crucial task of generational renewal and the need to promote the clinician scientist career. We need to reinforce innovation and technology translation to attain the highest impact in clinical practice and optimize the resources to achieve the desired objectives. Next year will be crucial for the institutional fusion of IDIBAPS and Fundació Clínic per a la Recerca Biomèdica (SUMA project), which should facilitate research in the Clínic Barcelona Campus.

This year, the Board of Governors accepted the nomination of Prof José María Mato as new President of the Scientific Advisory Board (SAB), replacing Prof Jesús Ávila, who remains as member of the SAB. We welcome Prof Amparo Cano, Full Professor of the Autonomous University of Madrid and researcher at the Institute of Biomedical Research “Alberto Sols”, and Dr Pura Muñoz, ICREA researcher at Pompeu Fabra University, as new members of the SAB,replacing Dr Guadalupe García-Tsa, Roberto Grozman, Bartolome Celli and Miguel Ángel Pozo. We are extremely grateful to all of them for their contributions to the success of IDIBAPS. The SAB is instrumental in guaranteeing the high standards in the scientific goals of the Institute.

This year, the Direction and Administration of IDIBAPS also made an extra effort to provide all the key performance Indicators (KPIs) required by the Instituto de Salud Carlos III Health Institute (ISCIII) to renew our accreditation as . In addition, we compiled all the documents requested by Fundación Científica de la Asociación Española Contra el Cáncer (FC-AECC) to obtain the new accreditation as a recognized center in Cancer Research.

The major strength of IDIBAPS continues to be the intense and excellent scientific production of its researchers, who in 2018 have maintained the high level reached in previous years. Of more than 1,100 original articles published, almost 350 (31%) were in first-decile journals and 170 (16%) in top journals (impact factor over 10). Our researchers also published 314 reviews and editorial articles, which underscores the high level of international leadership of our researchers. These excellent contributions encompass a broad spectrum of activities, from novel discoveries that are changing treatment standards to basic studies that improve understanding of the diseases in question. It would be difficult to summarize the tremendous amount of contributions, but some examples worthy of mention include the seminal contributions in the treatment of hepatocellular carcinoma, nosocomial pneumonia, cardiac arrhythmias, and the use of stem cells for the treatment of chronic inflammatory bowel disease. They have also provided important novel information on the evolution of diseases such as autoimmune encephalitis and hepatitis C. From a more basic perspective, our scientists have developed animal models for understanding liver fibrosis and treatment of cirrhosis, and have elucidated the genome-wide epigenomic modifications that shape the development of chronic lymphocytic leukemia. I should also mention the 39 international clinical guidelines, in which our researchers have participated, setting the standards for diagnostic procedures and therapeutic management of a variety of diseases–clear proof of the institutional spirit and commitment to translate research into clinical practice.

To sustain this production activity, IDIBAPS researchers have raised a significant amount of national and international funds, with more than 200 new projects from competitive and private sources. Indeed, IDIBAPS appears to be one of the national institutions with a better success rate in the ISCIII and H2020 programs. In 2018, two groups from IDIBAPS obtained a prestigious ERC Synergy grant in collaboration with two groups from CNAG-CRG to participate in the international project of the Human

9

Cell Atlas and study the chronic lymphocytic leukemia at a single cell level. Three groups obtained the highly competitive grants from the La Caixa Health program, two groups participate in major European consortiums funded by the FC-AECC, together with charities from the UK (CRUK) and Italy (AIRC) to study hepatocellular carcinoma and early manifestations of hematological disorders, and one group obtained a PO1 grant from the National Institutes of Health of the USA.

A special extraordinary achievement that deserves our deepest gratitude is the commitment and generosity of more than 1,600 donors raising more than one million euros, which has made it possible to initiate the immunotherapy program with the innovative CAR-T cell strategies in the project that we have named the ARI-project, after the lovely person who inspired all of us in this endeavor and who we all miss.

None of all this would have been possible without the commitment of our researchers. In 2018, we welcomed two new junior group leaders, Patricia Pérez-Galán as head of the group Microenvironment in lymphoma pathogenesis and therapy and Virginia Amador as head of the group Functional characterization of oncogenic mechanisms in lymphomagenesis. Our Junior Group Leader Iñaki Martín-Subero was also awarded an ICREA professor position. We should all be proud of the recognition of Dr Àlvar Agustí as the 2018 Clinical Biomedical Research awardee of the Lilly Foundation and of the inclusion of 13 of our researchers among the 1% most cited investigators according to Clarivate Analytics.

IDIBAPS is firmly committed to promoting the education of the young scientific community. In 2018, 96 students defended their theses. We have organized 41 institutional seminars and a special mention goes to our Stepping-Stone training program, which seeks to provide young researchers at IDIBAPS with the non-scientific tools and skills that are key to the development of their careers. One of the major difficulties we have continued to face in 2018 is limited institutional funding for renewing and improving our support infrastructure. Nevertheless, IDIBAPS core facilities are making a tremendous effort to help our scientists reach their objectives. The activity of our five core facilities has increased significantly, providing almost 600 services. In 2018, the Biobank, the KTT and the Clinical Trials Unit, were recognized by the ISCIII as key participants in the respective national networks, Red Nacional de Biobancos, ITEMAS and SCREN. Of particular importance was the grant obtained from the Spanish Ministry of Science, Innovation and Universities to renew our informatics infrastructure. This support will allow us to meet the needs of our groups and expand the power of the many projects developed in our institution on the generation and analysis of biomedical big data.

Science needs to reach and permeate our society. We have developed new initiatives to reinforce our commitment in this regard. In 2018, we organized 48 activities that reached 2,131 people of all ages, from 4 years old in the Science Summer Camps and programs for young students who want to follow a scientific career, to the most elderly attending the talks at the Urgell Civic Center. It is notable that some of these activities received competitive funding from Barcelona City Council. We also began construction of the new website, which will improve the visibility of our researchers and of the institution. This new website will be linked to the new website of Hospital Clínic de Barcelona and the Portal Clínic, to reinforce collaboration between the two institutions.

We are well prepared to face the challenges that 2019 will bring us. Of particular importance is the continuing implementation of our Strategic Plan in a context of social change and economical constraint that, conditions that, we must acknowledge, are jeopardizing the high levels of scientific achievement not only of IDIBAPS but of the entire scientific community in our country. Our commitment as an institution and as individual researchers is unquestionably pushing science forward. Our greatest reward is to experience for ourselves how this work improves the life of our patients. IDIBAPS will continue to be an excellent benchmark center in this endeavor.

Elías Campo

Director

10

About IDIBAPS

Additionally, 3 transversal groups perform research in Primary Care, Nursing, Pharmacology and Clinical Trials.

The Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) is a biomedical research institute of excellence. It combines clinical and basic research in order to accelerate the translation of the knowledge to the benefit of the patients. IDIBAPS is a CERCA (Research Centers of Catalonia) center and was first accredited as Instituto de Investigación Sanitaria (Instituto de Salud Carlos III) in 2009.

Scientific breakthroughs are never the result of chance. They are the fruit of long-term commitments that involve not only researchers, but also society as a whole.

IDIBAPS is a consortium that has made such a commitment, to encourage translational research, innovation and technological progress in the field of biomedicine, through different programmes addressing diseases with a high prevalence, morbidity and mortality in our society.
Founded in 1996, it is a public consortium formed by the Generalitat de Catalunya, Hospital Clínic de Barcelona, School of Medicine and Health Sciences of the University of Barcelona and, as an associated partner, the CSIC’s Barcelona Biomedical Research Institute.
The data presented in this Annual Scientific Report details the ever-growing scientific achievements made by IDIBAPS investigators and their capacity for attracting public and private funding. This enormous potential for capturing resources and their translation into applied results for clinical practice constitute the best guarantee for securing the future of the Institute and its impact on society and industry.
The Fundació Clínic per a la Recerca Biomèdica (FCRB) is a key institution to understand the functioning of IDIBAPS as a whole. It is a research foundation that provides researchers with administrative and management support. The IDIBAPS research community is composed of more than 1,500 people, grouped into 107 groups organized across 5 different areas of knowledge.

AREA 1

Biological aggression and response mechanisms

AREA 2

Respiratory, cardiovascular and renal pathobiology and bioengineering

AREA 3

Liver, digestive system and metabolism

AREA 4

Clinical and experimental neuroscience

AREA 5

Oncology and haematology

11

FOREWORD IDIBAPS

Organisation chart

IDIBAPS requires a solid administrative infrastructure to support the state of the art research developed by its researchers.

IDIBAPS works together with the Fundació Clínic per a la Recerca Biomèdica (FCRB) to ensure efficiency and quality in the services offered to its research staff, in particular, in the areas of research project management and administration.

Marga Nadal, PhD

Director of Strategy

Elías Campo, MD PhD

Director of IDIBAPS and of FCRB

Rosa Vilavella

General Manager

Arantxa Fernández

Secretary

Gemma Pedrola

Secretary

Laura Lopera

Secretary [email protected] T.+34 93 227 18 30 CEK, mezzanine floor [email protected] T. +34 93 312 94 11 CEK, mezzanine floor [email protected] T. +34 93 227 18 42 CEK, mezzanine floor

Gemma Llaverías

Head of the Scientific Coordination Office

Marta Fernández

Head of the Human Resources Office

Sònia Meléndez

Head of the Accounting and Finance Office

Elisenda Vendrell

Head of the KTT Office

Ernest Costa

Head of the TIC Office

Daniel Arbós

Head of the Communication Office

Juan Suero

Head of the Purchasing

Gemma Pascual

Head of the Institutional Actions Office and General Services Office

Sandra Piquer

Coordinator of IDIBAPS laboratories

Guillem Masdeu

Head of the Legal Office

Aina Rodríguez

Head of IDIBAPS core facilities and Biobank coordinator

RESEARCH MANAGEMENT OFFICE

Sandra Pérez

Head of the Pre-Award Office for National Grants

Juan Abolafia

Head of the Pre-Award Office for International Grants

Judit Martínez

Head of the Post-award Grants Office

12

Governance and structure

Governance is exercised through the following boards and committees:

THE SCIENTIFIC ADVISORY BOARD

Jesús San Miguel

Hospital Clínico de Salamanca

THE BOARD OF GOVERNORS
External leading scientists chosen by the Board of Governors, compose this board to advise IDIBAPS on the different scientific issues affecting its activities. These leading scientists have in-depth knowledge of the Spanish, European and/or American R+D+I systems as they hold positions in prestigious research institutions.
Conformed by representatives of the different institutions of the consortium, supervises IDIBAPS actions, budget and results. Its mission is to take scientific decisions in consultation with the Scientific Advisory Board, and to evaluate the implementation of the strategic plan.

Francisco Sánchez-Madrid

Hospital La Princesa, Madrid

Eugenio Santos

Centro de Investigación del Cáncer (CIC), Salamanca

Antonio Vidal-Puig

School of Clinical Medicine, University of Cambridge, UK

CHAIRMAN

Joan Gómez Pallarés

CHAIRMAN

General Director, Direcció General de Recerca, Departament d’ Empresa i Coneixement. Generalitat de Catalunya

José María Mato

CIC bioGUNE, Bilbao

BOARD MEMBERS

THE STEERING COMMITTEE

VICE-CHAIRMAN

Jesús Ávila

Centro de Biología Molecular Severo Ochoa (CBM), Madrid

Josep Maria Campistol

General Manager, Hospital Clínic de Barcelona

Which is responsible for the supervision of the progress achieved by the five IDIBAPS research areas, the recruitment of new scientists within the framework of different research programmes, and the evaluation of IDIBAPS training

Fernando Arenzana-Seisdedos

Institut Pasteur, Shangai, China

BOARD MEMBERS

Albert Barberà

General Director, Direcció General de Recerca I Innovació en Salut, Departament de Salut, Generalitat de Catalunya

Amparo Cano

Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid

programmes.

CHAIRMAN

Elías Campo

Director

Domènec Espriu

Research Vice-Dean, Universitat de Barcelona

Francisco Fernández Avilés

Hospital Gregorio Marañón, Madrid

MEMBERS

Lluís Calvo

Institutional Coordinator, Consejo Superior de Investigaciones Científicas (CSIC) in Catalonia

Ramon Gomis

IDIBAPS, Barcelona

Neus Agell

Vice-Dean of School of Medicine and Health Sciences

Universitat de Barcelona

José López Barneo

Instituto de Biomedicina de Sevilla (IBiS)

Francesc Cardellach

Dean of the School of Medicine, Universitat de Barcelona

Cristina Fillat

Group Leader

Carlos López Otín

Universidad de Oviedo

Gene therapy and cancer

Elías Campo

Director, IDIBAPS

  • Carlos Macaya
  • Joan Carles García-Pagán

Hospital Clínico San Carlos, Madrid

Antoni Castells

Medical Director, Hospital Clínic de Barcelona
Research Deputy Director (HCB)

Óscar Marín

King's College London, UK

Josep Maria Llovet

Group Leader

Translational research in hepatic oncology

Roser Cortés

Director, Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC)

Federico Mayor

Centro de Biología Molecular Severo Ochoa, Madrid

Anna Planas

Coordinator of the IDIBAPS Research Area 4

SECRETARY

Lluís Rovira

Director, CERCA

Pura Muñoz

ICREA, Universitat Pompeu Fabra

Rosa Vilavella

General Manager

Angel Pellicer

SECRETARY

NYU School of Medicine, New York, US

Marga Nadal

Strategy Director

Ciril Rozman

Hospital Clínic de Barcelona, Universitat de Barcelona

13

FOREWORD IDIBAPS

GUEST MEMBERS

THE INTERNAL ADVISORY COMMITTEE

The Clinical Research Ethics Committee (Comitè d’Ètica d’Investigació amb Medicaments - CEIm) of the HCB

[email protected]

Montserrat Batlle

Works Committee President

IDIBAPS researchers representing all research areas advise the IDIBAPS director to implement the strategic decisions taken by the Board of Governors.

Jaume Bosch

Researcher

Hepatic hemodynamics and portal hypertension

The Animal Experimentation Ethics Committee (Comitè d’Ètica d’Experimentació Animal - CEEA) of the UB

CHAIRMAN

Francesc Cardellach

Dean of the School of Medicine

Universitat de Barcelona

Elías Campo

Director

Biosafety Committee (CBS)

STEERING COMMITTEE REPRESENTATIVES

Josep Maria Llovet

Group Leader

[email protected]

Fàtima Crispi

Researcher

Fetal and perinatal medicine

Core Facilities Committees

[email protected]

Translational research in hepatic oncology

Roser Cortés

Director

Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC)

Joan Carles García-Pagán

Research Deputy Director

Hospital Clínic de Barcelona

Mentoring Committee Training Committee

[email protected]

INSTITUTIONAL REPRESENTATIVES

Joan Cid

Physicians’ Representatives

Hospital Clínic de Barcelona

Josep M. Gatell

National Coordinator of the RETIC on AIDS

Clinicians and Research Committee Ombuds Committee

Anna Novials Francesca Pons

Francesc Graus

Cellex building representative

Guadalupe Mengod

Deputy Director

Instituto de Investigaciones Biomédicas de Barcelona (IIBB-CSIC)

Marc Roda Joan Serratosa [email protected]

Anna Novials

Group Leader

Pathogenesis and prevention of diabetes

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    DIRECCIONES DE LAS OFICINAS DE REHABILITACION (O.R.V.E) 1.- O.R.V.E. DE PAMPLONA C/ Eslava, nº 1 (antigua Casa Luna).- 31001 – PAMPLONA Telf.: 948.224.951 Fax: 948.222.169 2.- O.R.V.E. DE LA COMARCA DE PAMPLONA C/ Joaquín Azcárate, nº 6-bajo.- 31600 – BURLADA Telf.: 948.130.233 Fax: 948.140.385 3.- O.R.V.E. DE TIERRA ESTELLA C/ Fray Diego, nº 3.- 31200 – ESTELLA Telf.: 948.552.250 / 203 Fax: 948.552.103 4.- O.R.V.E. DE SAKANA Gazteizbide.- 31830 – LAKUNTZA Telf.: 948.464.867 / 948.576.293 Fax: 948.464.853 En LEITZA tramitan los expedientes de algunas localidades (L) Tel.: 948.510.009 / 510.310 Fax.: 948.510.816 5.- O.R.V.E. DE LA COMARCA DE TAFALLA Pº Padre Calatayud, nº 1-1º.- 31300 – TAFALLA Telf.: 948.755.034 / 948.755.194 Fax: 948.704.080 6.- O.R.V.E. DE LA RIBERA Plaza de los Fueros, nº 7-2º (Casa del Reloj).- 31500 – TUDELA Telf.: 948.825.641 Fax: 948.826.492 7.- O.R.V.E. DEPARTAMENTO Avda. del Ejercito, 2.- 31002 - PAMPLONA NOTA: LAS LOCALIDADES Y O.R.V.E QUE LES CORRESPONDE ESTAN RELACIONADAS EN LAS PAGINAS SIGUIENTES Servicio de Vivienda LOCALIDADES Y O.R.V.E. QUE LES CORRESPONDE LOCALIDAD AYUNTAMIENTO O.R.V.E. Abáigar Abáigar Estella Abárzuza Abárzuza Estella Abaurrea Alta / Abaurregaina Abaurrea Alta / Abaurregaina Departamento Abaurrea Baja / Abaurrepea Abaurrea Baja / Abaurrepea Departamento Aberin Aberin Estella Abínzano Ibargoiti Departamento Ablitas Ablitas Tudela Acedo Mendaza Estella Acotáin / Akotain Lónguida / Longida Departamento Adansa Romanzado Departamento Adériz Ezcabarte Burlada Adiós Adiós Tafalla Adóain Urraúl
  • Desigualdades Territoriales En Navarra

    Desigualdades Territoriales En Navarra

    Desigualdades territoriales en Navarra www.unavarra.es/ciparaiis [email protected] Sagrario Anaut Miguel Laparra Ángel García Pamplona-Iruña, Mayo de 2014 1 Índice 1. Introducción ............................................................................................................... 3 2. Una población desigualmente distribuida y estructurada .................................. 5 3. Desigualdades territoriales en el nivel socioeducativo ...................................... 12 4. Desigualdades territoriales en materia de empleo ............................................ 16 5. Desigualdades territoriales en los niveles de ingresos ........................................ 21 6. Prestaciones sociales: ¿desigualdad insuficiente? ............................................. 25 7. Desigualdad en las condiciones de la vivienda y su entorno .......................... 28 8. El estado de salud: desigualdades en su percepción ....................................... 33 9. Conclusión: El reto de las desigualdades territoriales en Navarra ................... 36 Bibliografía .................................................................................................................... 39 Anexo: Municipios de las Zonas Navarra 2000 ........................................................ 40 2 1. Introducción Ubicar en el espacio físico acontecimientos, procesos, actividades económicas o sociales de toda índole, grupos específicos de población, etc., puede parecer una tarea sencilla si tan solo el territorio se entiende como un lugar
  • Lo Forestalillo

    Lo Forestalillo

    Generalitat de Catalunya Departament d’Interior Direcció General d'Emergències LLLooo FFFooorrreeessstttaaallliiillllllooo i Seguretat Civil Divisió Operativa NNNººº 888555 222111---666---222000000666 GRAF Situation of Forest Fires in Catalonia LLIIGGHHTTNNIINNGGSS,, RREESSCCOOLLDDSS AANNDD CCEERREEAALL FFIIEELLDDSS Effects of the behavior of the right flank in Alforja fire (13/6/2006) What we have had Compared tendency from 1/1/06 until: 18/06/2005 18/06/2006 Nº Services 4618 2361 (VA+VU+VF) Area (ha) 2174 1838 VA: services of agricultural fire VU: services of urban fire VF: services of forest fire FAITH OF ERRORS: From the Forestalillo 81 we come an erroneous datum in the number of hectares during 2006, due to the management of the data base. So we were amounting twice the burned area of Number of services (VA+VU+VF) from 01/05 Vandellòs fire. With this faith, it remains the until 18/06/06, and services larger than >2 ha. datum corrected and it is brought to light. Generalitat de Catalunya Departament d’Interior Direcció General d'Emergències i Seguretat Civil Divisió Operativa GRAF DDDeeessscccrrriiippptttiiiooonnn ooofff ttthhheee sssiiitttuuuaaatttiiiooonnn EEEvvvooollluuutttiiiooonnn ooofff dddrrrooouuuggghhhttt (((aaavvvaaaiiilllaaabbbiiillliiitttyyy ooofff llliiivvveee fffuuueeelll,,, aaannnddd lllaaarrrgggeee dddeeeaaaddd fffuuueeelllsss))) The predicted period of instability has arrived at last, although it has not been generalized all over the territory as it was predicted. We have had isolated cloudbursts in the metropolitan regions, and intense storms in the Pyrinees area. However, the effects of these rains are not going to last, and the lightings that felt down with the rain woke up four days afterwards. During the 4 last days, the availability of the dead fine fuel has been scarce, and the effect has been noticed with a decrease in the services of agricultural vegetation.
  • Aguilar De Segarra / 797 AGUILAR DE SEGARRA

    Aguilar De Segarra / 797 AGUILAR DE SEGARRA

    AGUILAR DE SEGARRA / 797 AGUILAR DE SEGARRA Aguilar de Segarra está situado en el extremo occidental de la comarca del Bages, cerca de las estri- baciones orientales del altiplano de la Segarra, encuadrado por las cuencas de los ríos Segre, Anoia y Llobregat. Dista 23 km de Manresa y accedemos desde la C-25 en dirección a Cervera, tomando la salida 114 (Aguilar de Segarra/Fonollosa). El actual término se formó con tierras escindidas de los castillos de Aguilar y Castellar, que llegaron a ser municipios independientes hasta su unificación en el siglo XIX, y los términos más meridionales del castillo de Maçana. Los lugares de Aguilar y Cas- tellar aparecen citados en la consagración de la iglesia del monasterio de Sant Llorenç prop Bagà (Guardiola de Berguedà) en 983, aunque el castillo de Aguilar está documentado con anterioridad. Castillo de Aguilar AS RUINAS DEL ANTIGUO CASTILLO se conservan en la ver- obispos vicenses infeudarán la fortaleza a Hug Dalmau de tiente sureste de una colina (el cementiri vell) que dista 1,5 Cervera en 1066, en manos de cuya familia continuó durante Lkm al noroeste de Aguilar de Segarra. Hay que tomar el siglo XII. Los Cervera la cederán a unos castlans que tomaron la carretera BV-3008 hasta superar el km 20, donde una pista el nombre de Aguilar y ejercieron su poder hasta bien entra- que parte hacia la derecha nos conduce hasta la fortaleza, do el siglo XIII. Terminó en manos del pavorde (administrador cuyos escasos restos aparecen completamente cubiertos por general) de la canónica de Santa Maria de Manresa hasta la vegetación circundante.
  • Plan Hidrológico De Los Ríos Queiles Y Huecha

    Plan Hidrológico De Los Ríos Queiles Y Huecha

    Resumen de las reuniones de participación de los ríos Queiles y Huecha - 1 de 39- PLAN HIDROLÓGICO DE LOS RÍOS QUEILES Y HUECHA RESUMEN DE LAS REUNIONES DE PARTICIPACIÓN Enero de 2008 Resumen de las reuniones de participación de los ríos Queiles y Huecha - 2 de 39- Resumen de las reuniones de participación de los ríos Queiles y Huecha - 3 de 39- COMENTARIOS APORTADOS DURANTE EL PROCESO DE PARTICIPACIÓN DE LAS CUENCAS DE LOS RÍOS QUEILES Y HUECHA Nota: Este resumen tiene el objetivo de recoger todas las propuestas aportadas por los asistentes a las reuniones. No debe entenderse que existía un acuerdo unánime por parte de los asistentes en cada una de ellas. Sesión de agentes sociales y medioambientales Fecha reunión: 13/12/2007 Sugerencias principales: 1. RÍO QUEILES a) Cumplimiento de los objetivos medioambientales - Realizar un inventario de ríos en los que habitan especies catalogadas, al objeto de evitar actuaciones que pongan en peligro su supervivencia (cangrejo autóctono, endemismos botánicos, visón europeo). - Elaboración por parte de la Universidad de Zaragoza de un Estudio Integral de las Riberas de Aragón. Mediante la creación de Catálogos provinciales de Riberas sobresalientes. - Realizar un inventario de bosques de chopos cabeceros junto a un programa de tratamiento y consolidación. - Prohibición expresa de la corta de vegetación autóctona. - Aplicación de técnicas de Restauración de ríos y riberas. - Establecimiento de caudalímetros medidores del caudal ecológico en los ríos y afluentes más importantes. - Se debe prestar un tratamiento adecuado de conformidad a la normativa vigente de depuración de aguas residuales a todas las poblaciones que vierten sus aguas residuales en la cuenca del Queiles.
  • Relació De PARADES De Transport Escolar (Tots Els Centres Educatius

    Relació De PARADES De Transport Escolar (Tots Els Centres Educatius

    CENTRE EDUCATIU PARADA FONOLLOSA ‐ Ctra. BV‐3008. Granja Pujol Torras FONOLLOSA (Fals)– Restaurant Molí de Boixeda FONOLLOSA ‐ Can Baló FONOLLOSA (CAMPS)‐ Cruïlla Ctra. a Camps FONOLLOSA (CANET DE FALS) ‐ Ctra. BV‐3008. (Restaurant 10 d’Últimes) FONOLLOSA (CANET DE FALS) ‐ C/ Ramon Oliveras ESCOLA AGRUPACIÓ FONOLLOSA (CANET DE FALS) ‐ La Masia SANT JORDI FONOLLOSA (FALS) – Parc Infantil FONOLLOSA (Goscan) RAJADELL ‐ L’Estació (FONOLLOSA) RAJADELL ‐ N‐141. Rètol Les Casetes RAJADELL ‐ Els Molins RAJADELL – Rètol Monistrolet (sota el pont) RAJADELL – Can Servitge AGUILAR DE SEGARRA‐CASTELLAR – El Molinot N‐141, km.3 AGUILAR DE SEGARRA‐CASTELLAR – Nucli urbà AGUILAR DE SEGARRA ‐ Església de Sant Andreu AGUILAR DE SEGARRA ‐ Trencall de Cal Vendrell AGUILAR DE SEGARRA ‐ Sortida 114 (C‐25) AGUILAR DE SEGARRA ‐ Entrada camí dels Plans SANT JOAN DE VILATORRADA – Zona Esportiva (només si l'esteu utilitzant actualment) SANT JOAN DE VILATORRADA – C/ Collbaix (només si l'esteu utilitzant actualment) SANT MATEU DE BAGES ‐ CASTELLTALLAT SANT MATEU DE BAGES‐ CASTELLTALLAT ( PLAÇA AJUNTAMENT) ESCOLA MONSENYOR GIBERT SANT FRUITOS DE BAGES‐ROSALEDA ‐ Parada bus SANT FRUITOS DE BAGES‐TORROELLA ‐ Parada bus ‐ SANT FRUITÓS DE BAGES ‐ SANT FRUITOS DE BAGES‐LES BRUCARDES ‐ C/ del Serrat s/n. Cantonada. Avinguda Brucardes MANRESA ‐ La Catalana (Barri Tres Creus / Barri Vista Alegre) ESCOLA MUNTANYA DEL DRAC MANRESA ‐ Plaça Valldaura MANRESA ‐ Plaça Infants (MANRESA) MANRESA ‐ Carrer Dos de Maig (Aldi) MANRESA ‐ (Bonavista) ESCOLA PLA DEL PUIG SANT FRUITOS DE
  • Las Cofradías De La Vera Cruz En El Reino De Navarra (Siglos Xvi-Xviii)^

    Las Cofradías De La Vera Cruz En El Reino De Navarra (Siglos Xvi-Xviii)^

    Gregorio Silanes Susaeta Hispania Sacra, Vol 52 Num 106 (2000) LAS COFRADÍAS DE LA VERA CRUZ EN EL REINO DE NAVARRA (SIGLOS XVI-XVIII)^ POR GREGORIO SILANES SUSAETA* RESUMEN Las primeras cofradías de la Vera Cruz se ftindan en el reino de Navarra en la segunda mitad del siglo XVI, en aplicación de las disposiciones del Concilio de Trento. En estas páginas se describe su forma de organización y los principa- les cometidos que realiza. ABSTRACT The first confraternities of the Vera Cruz are established in the Kingdom of Navarra in second half of the XVIth century, in application of the arrangements of the Council of Trento. In these pages is described their form of organization and the principal assignments that accomplishes. L INTRODUCCIÓN La Semana Santa tal y como la conocemos hoy comenzó a forjarse en Espa- ña desde finales d e la Edad Media^. Las principales artífices de la organización * Dr. en Historia por la Universidad Pública de Navarra. ' Siglas principales: ADP Archivo Diocesano de Pamplona. AMP: Archivo Municipal de Pamplona. AHN: Archivo Histórico Nacional. ^ J. SÁNCHEZ HERRERO, «Las cofradías de Semana Santa de Sevilla durante la modernidad. Siglos XV a XVII», en R. SÁNCHEZ MANTERO et al.. Las cofradías de Sevilla en la modernidad, Sevilla, 1991, pp. 50-52. Actas del I Congreso de Historia de la Iglesia y el Mundo Hispánico Hispania Sacra, 52 (2000) (C) Consejo Superior de Investigaciones Científicas http://hispaniasacra.revistas.csic.es Licencia Creative Commons Attribution (CC-by) 3.0 España 458 GREGORIO SILANES SUSAETA de las procesiones fueron las cofradías, especialmente las de la Vera Cruz, exis- tentes en infinidad de localidades.