DOCSLIB.ORG

Cardiovascular and Lymphatic Systems

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

Cardiovascular and 7 Lymphatic Systems Chapter Outline Anatomy and Physiology, 196 Prefi xes, 205 Functions of the Cardiovascular Suffi xes, 205 System, 196 Medical Terms, 209 Structures of the Cardiovascular Adjectives and Other Related System, 196 Terms, 209 Functions of the Lymphatic Symptoms and Medical Conditions, 211 System, 196 Tests and Procedures, 221 Structures of the Lymphatic Surgical Interventions and System, 197 Therapeutic Procedures, 226 Terms Related to the Cardiovascular Medications and Drug Therapies, 231 and Lymphatic Systems, 197 Specialties and Specialists, 232 Word Parts, 204 Abbreviations, 233 Combining Forms, 204 Chapter Review, 236 Objectives After completion of this chapter you will be able to: 1. Describe the location of the main cardiovascular and lymphatic structures in the body. 2. Defi ne terms related to the heart, the vascular system, and the lymphatic system. 3. Defi ne combining forms, prefi xes, and suffi xes related to the cardiovascular and lymphatic systems. 4. Defi ne common medical terminology related to the cardiovascular and lymphatic systems, including adjectives and related terms, symptoms and conditions, tests and procedures, surgical interventions and therapeutic procedures, medications and drug therapies, and specialties. 5. Explain abbreviations for terms related to the cardiovascular and lymphatic systems. 6. Successfully complete all chapter exercises. 7. Explain terms used in medical records and case studies involving the cardiovascular and lymphatic systems. 8. Successfully complete all pronunciation and spelling exercises, and complete all interactive exercises included with the companion Student Resources. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 119595 110/19/100/19/10 99:43:06:43:06 PPMM 196 MEDICAL TERMINOLOGY ANATOMY AND PHYSIOLOGY Functions of the Cardiovascular System ᭿ To transport blood throughout the body (Fig. 7-1) ᭿ To deliver oxygen and nutrients to body cells through arteries and capillaries ᭿ To remove waste products from body cells through capillaries and veins ᭿ To pump blood through the heart with the aid of electrical conduction Structures of the Cardiovascular System ᭿ The heart wall consists of three tissue layers. ᭿ The heart has four chambers aided by four valves to keep blood moving in one direction. ᭿ The heart has specialized tissue that transmits electrical impulses. ᭿ The heart muscle contracts in a rhythmic sequence, pushing blood through the chambers and vessels. ᭿ The arteries carry blood away from the heart. ᭿ The capillaries allow exchange of gasses, nutrients, and wastes between the blood and body cells. ᭿ The veins return blood back to the heart. Functions of the Lymphatic System ᭿ To return lymph from body tissues to the blood (Fig. 7-1) ᭿ To protect the body by fi ltering microorganisms and foreign particles from the lymph ᭿ To maintain the body’s internal fl uid level ᭿ To absorb fats from the small intestines Circulation to upper body Lymph Venule nodes Lymph capillary Blood capillary Lymph vessel Lymph vessel Arteriole Tissue cells Circulation to lower body Figure 7-1 Blood and lymph fl ow in the cervical region. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 119696 110/19/100/19/10 99:43:08:43:08 PPMM Chapter 7 Cardiovascular and Lymphatic Systems 197 Structures of the Lymphatic System ᭿ The lymph is clear tissue fl uid consisting of white blood cells and a few red blood cells. ᭿ The lymph nodes fi lter the lymph. ᭿ The lymph nodes are primarily concentrated in the neck, chest, armpits, and groin. ᭿ The lymph vessels transport the lymph from the body tissues to the venous system. ᭿ The lymph vessels have valves that facilitate one-way transport of lymph. Terms Related to the Cardiovascular and Lymphatic Systems Term Pronunciation Meaning The Heart (Fig. 7-2) cardiovascular system kahr’dē-ō-vas’kyū-lăr heart and blood vessels carrying oxygen and nutrients to the sis’tĕm body cells and carrying away waste (Fig. 7-3) heart hahrt muscular organ taking deoxygenated blood from the veins, pumping it to the lungs for oxygen, and returning it to the body through the arteries (Fig. 7-4) (continued) View the animation Cardiac Cycle on the Student Resources to learn how blood fl ows through the heart. Aorta Superior vena cava Left pulmonary artery Right pulmonary artery Right pulmonary veins Left pulmonary veins Pulmonary valve Left atrium Right atrium Aortic valve Mitral valve Tricuspid valve Endocardium Epicardium Left ventricle Right ventricle Myocardium Inferior vena cava Septum Apex Figure 7-2 Heart and great vessels. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 119797 110/19/100/19/10 99:43:12:43:12 PPMM 198 MEDICAL TERMINOLOGY Heart Artery Vein Pericardial sac (cut edge) Superior vena cava Left pulmonary artery Right lung Left atrium Pericardial sac (cut edge) Capillaries Left lung Right atrium Pericardium (cut edge) Right ventricle Left ventricle Apex of heart Figure 7-3 The cardiovascular system. Figure 7-4 Cross-section of the heart and lungs showing the heart’s relative position in the body. Terms Related to the Cardiovascular and Lymphatic Systems (continued) Term Pronunciation Meaning apex ā’peks the lower pointed end of the heart septum sep’tŭm wall of heart tissue separating the right and left sides atrium ā’terē-ŭm upper receiving chamber of the heart; right and left ventricle ven’tri-kĕl lower pumping chamber of the heart; right and left structures endocardium en’dō-kahr’dē-ŭm inner lining of the heart myocardium mī’ō-kahr’dē-ŭm middle muscular layer of heart tissue epicardium ep’i-kahr’dē-ŭm outer lining of the heart pericardium per’i-kahr’dē-ŭm sac around the heart that facilitates movement of the heart as it beats (continued) LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 119898 110/19/100/19/10 99:43:13:43:13 PPMM Chapter 7 Cardiovascular and Lymphatic Systems 199 Terms Related to the Cardiovascular and Lymphatic Systems (continued) Term Pronunciation Meaning aortic valve ā-ōr’tik valv heart valve between the left ventricle and aorta mitral valve mī’trăl valv heart valve between the left atrium and left ventricle; also called a bicuspid valve pulmonary valve pul’mŏ-nār-ē valv heart valve between the right ventricle and the pulmonary artery; also called a semilunar valve due to the half-moon shape of its three cusps tricuspid valve trī-kŭs’pid valv heart valve between the right atrium and right ventricle; also called a semilunar valve due to the half-moon shape of its three cusps The Vascular System blood vessels blŭd ves’ĕlz structures that carry or transport blood artery ar’tĕr-ē vessel carrying blood away from the heart (Fig. 7-5) arteriole ahr-tēr’ē-ōl small artery (continued) Superficial temporal Superior temporal Frontal Common Vertebral carotid Transverse Occipital facial Subclavian Aortic arch Brachiocephalic Vertebral Labial Intercostals External Axillary Celiac carotid Maxillary Brachial Renal Internal Testicular carotid Superior Radial Common thyroid Ulnar Inferior carotid mesenteric Volar arch Thoracic aorta Common Volar iliac Superior metacarpals Internal mesenteric iliac Digitals Femoral External iliac Deep femoral Popliteal Anterior tibial Genicular Posterior tibial Peroneal Dorsalis pedis Dorsal metatarsals Figure 7-5 The principal arteries. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 119999 110/19/100/19/10 99:43:16:43:16 PPMM 200 MEDICAL TERMINOLOGY Terms Related to the Cardiovascular and Lymphatic Systems (continued) Term Pronunciation Meaning capillary kap’i-lār-ē microscopic thin-walled vessel connecting arterioles and venules where gas, nutrient, and waste exchange take place between the blood and cells of the body lumen lū’mĕn interior space of a vessel venule ven’yūl small vein vein vān vessel carrying blood to the heart aorta ā-ōr’tă largest artery that begins as an arch from the left ventricle then branches and descends through the thoracic and abdominal cavities; carries oxygenated blood away from the heart inferior vena cava in-fēr’ē-ŏr vē’nă kā’vă large vein carrying blood to the heart from the lower part of the body (Fig. 7-6) superior vena cava sŭ-pēr’ē-ŏr vē’nă kā’vă large vein carrying blood to the heart from the upper part of the body (Fig. 7-6) The Lymphatic System (Fig. 7-7) lymph limf clear fl uid consisting of fl uctuating amounts of white blood cells and a few red blood cells that accumulates in tissue and is removed by the lymphatic capillaries lymph nodes, syn. limf nōdz, limf glandz small bean-shaped masses of lymphatic tissue that fi lter lymph glands bacteria and foreign material from the lymph; located on larger lymph vessels in the axillary, cervical, inguinal, and mediastinal areas (Fig. 7-8) lymph vessels limf ves’ĕlz vessels transporting lymph from body tissues to the venous system lymph capillaries limf kap’i-lar-ēz microscopic thin-walled lymph vessels that pick up lymph, proteins, and waste from body tissues lymph ducts limf dŭkts the largest lymph vessels that transport lymph to the venous system Superior vena cava Inferior vena cava Figure 7-6 The venae cavae carry blood to the heart. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 220000 110/19/100/19/10 99:43:16:43:16 PPMM Chapter 7 Cardiovascular and Lymphatic Systems 201 Cervical lymph node Mediastinal lymph node Axillary lymph node Inguinal lymph node Figure 7-7 Major lymph node locations. Afferent lymphatic vessel Lymph node artery (red) and vein (blue) Lymph continuing Efferent toward venous system Lymph from lymphatic body tissues vessel Figure 7-8 The interior of a lymph Lymph nodule node. LLWBK568-C07_195-252.inddWBK568-C07_195-252.indd 220101 110/19/100/19/10 99:43:17:43:17 PPMM 202 MEDICAL TERMINOLOGY ᭿ Exercises: Anatomy and Physiology Exercise 1 Write the correct anatomic structure for the meaning given. 1. upper chamber of the heart 2. small vein 3. middle muscular layer of heart 4.
Recommended publications
  • 29 Assessing the Cardiovascular and Lymphatic Systems

    29 Assessing the Cardiovascular and Lymphatic Systems

    29 Assessing the Cardiovascular and Lymphatic Systems LEARNING OUTCOMES 1. Describe the anatomy, physiology, and functions of the 5. Explain techniques used to assess cardiovascular and cardiovascular and lymphatic systems. lymphatic structure and function. 2. Describe normal variations in cardiovascular assessment 6. Identify manifestations of impaired cardiovascular structure findings for the older adult. and functions. 3. Give examples of genetic disorders of the cardiovascular system. 4. Identify specific topics for consideration during a health history assessment interview of the patient with cardiovascu- lar or lymphatic disorders. CLINICAL COMPETENCIES 1. Complete a health history for patients having alterations in 3. Assess an ECG strip and identify normal rhythm and cardiac the structure and functions of the cardiovascular or lymphatic events and abnormal cardiac rhythm. systems. 4. Monitor the results of diagnostic tests and communicate 2. Conduct and document a physical assessment of cardiovas- abnormal findings within the interprofessional team. cular and lymphatic status. MAJOR CHAPTER CONCEPTS • Correct structure and function of the cardiovascular and • Manifestations of dysfunction, injury, and disorders affecting lymphatic systems are vital to the transport of oxygen and the cardiovascular and lymphatic systems may be detected carbon dioxide throughout the body and for the return of during a general health assessment as well as during focused excess tissue fluids back to the bloodstream. cardiovascular and lymphatic system
  • Vocabulario De Morfoloxía, Anatomía E Citoloxía Veterinaria

    Vocabulario De Morfoloxía, Anatomía E Citoloxía Veterinaria

    Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) Servizo de Normalización Lingüística Universidade de Santiago de Compostela COLECCIÓN VOCABULARIOS TEMÁTICOS N.º 4 SERVIZO DE NORMALIZACIÓN LINGÜÍSTICA Vocabulario de Morfoloxía, anatomía e citoloxía veterinaria (galego-español-inglés) 2008 UNIVERSIDADE DE SANTIAGO DE COMPOSTELA VOCABULARIO de morfoloxía, anatomía e citoloxía veterinaria : (galego-español- inglés) / coordinador Xusto A. Rodríguez Río, Servizo de Normalización Lingüística ; autores Matilde Lombardero Fernández ... [et al.]. – Santiago de Compostela : Universidade de Santiago de Compostela, Servizo de Publicacións e Intercambio Científico, 2008. – 369 p. ; 21 cm. – (Vocabularios temáticos ; 4). - D.L. C 2458-2008. – ISBN 978-84-9887-018-3 1.Medicina �������������������������������������������������������������������������veterinaria-Diccionarios�������������������������������������������������. 2.Galego (Lingua)-Glosarios, vocabularios, etc. políglotas. I.Lombardero Fernández, Matilde. II.Rodríguez Rio, Xusto A. coord. III. Universidade de Santiago de Compostela. Servizo de Normalización Lingüística, coord. IV.Universidade de Santiago de Compostela. Servizo de Publicacións e Intercambio Científico, ed. V.Serie. 591.4(038)=699=60=20 Coordinador Xusto A. Rodríguez Río (Área de Terminoloxía. Servizo de Normalización Lingüística. Universidade de Santiago de Compostela) Autoras/res Matilde Lombardero Fernández (doutora en Veterinaria e profesora do Departamento de Anatomía e Produción Animal.
  • Corpora Amylacea Act As Containers That Remove Waste Products from the Brain

    Corpora Amylacea Act As Containers That Remove Waste Products from the Brain

    Corpora amylacea act as containers that remove waste products from the brain Marta Ribaa,b,c,1, Elisabet Augéa,b,c,1, Joan Campo-Sabariza,d, David Moral-Antera,d, Laura Molina-Porcele, Teresa Ximelise, Ruth Ferrera,d, Raquel Martín-Venegasa,d, Carme Pelegría,b,c,2, and Jordi Vilaplanaa,b,c,2 aSecció de Fisiologia, Departament de Bioquímica i Fisiologia, Universitat de Barcelona, 08028 Barcelona, Spain; bInstitut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain; cCentros de Biomedicina en Red de Enfermedades Neurodegenerativas (CIBERNED), 28031 Madrid, Spain; dInstitut de Recerca en Nutrició i Seguretat Alimentàries (INSA-UB), Universitat de Barcelona, 08291 Barcelona, Spain; and eNeurological Tissue Bank of the Biobanc- Hospital Clinic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain Edited by Lawrence Steinman, Stanford University School of Medicine, Stanford, CA, and approved November 5, 2019 (received for review August 8, 2019) Corpora amylacea (CA) in the human brain are granular bodies 6). Nonetheless, we observed that CA contain glycogen synthase formed by polyglucosan aggregates that amass waste products of (GS), an indispensable enzyme for polyglucosan formation, and different origins. They are generated by astrocytes, mainly during also ubiquitin and protein p62, both associated with processes of aging and neurodegenerative conditions, and are located predom- elimination of waste substances (5). The relationship between CA inantly in periventricular and subpial regions. This study shows that and waste substances is recurrent in the literature. Already in 1999, CA are released from these regions to the cerebrospinal fluid and after a detailed and complete review, Cavanagh indicated that “CA are present in the cervical lymph nodes, into which cerebrospinal functions seem to be directed towards trapping and sequestration fluid drains through the meningeal lymphatic system.
  • Adaptive Immune Systems

    Adaptive Immune Systems

    Immunology 101 (for the Non-Immunologist) Abhinav Deol, MD Assistant Professor of Oncology Wayne State University/ Karmanos Cancer Institute, Detroit MI Presentation originally prepared and presented by Stephen Shiao MD, PhD Department of Radiation Oncology Cedars-Sinai Medical Center Disclosures Bristol-Myers Squibb – Contracted Research What is the immune system? A network of proteins, cells, tissues and organs all coordinated for one purpose: to defend one organism from another It is an infinitely adaptable system to combat the complex and endless variety of pathogens it must address Outline Structure of the immune system Anatomy of an immune response Role of the immune system in disease: infection, cancer and autoimmunity Organs of the Immune System Major organs of the immune system 1. Bone marrow – production of immune cells 2. Thymus – education of immune cells 3. Lymph Nodes – where an immune response is produced 4. Spleen – dual role for immune responses (especially antibody production) and cell recycling Origins of the Immune System B-Cell B-Cell Self-Renewing Common Progenitor Natural Killer Lymphoid Cell Progenitor Thymic T-Cell Selection Hematopoetic T-Cell Stem Cell Progenitor Dendritic Cell Myeloid Progenitor Granulocyte/M Macrophage onocyte Progenitor The Immune Response: The Art of War “Know your enemy and know yourself and you can fight a hundred battles without disaster.” -Sun Tzu, The Art of War Immunity: Two Systems and Their Key Players Adaptive Immunity Innate Immunity Dendritic cells (DC) B cells Phagocytes (Macrophages, Neutrophils) Natural Killer (NK) Cells T cells Dendritic Cells: “Commanders-in-Chief” • Function: Serve as the gateway between the innate and adaptive immune systems.
  • Human Anatomy As Related to Tumor Formation Book Four

    Human Anatomy As Related to Tumor Formation Book Four

    SEER Program Self Instructional Manual for Cancer Registrars Human Anatomy as Related to Tumor Formation Book Four Second Edition U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutesof Health SEER PROGRAM SELF-INSTRUCTIONAL MANUAL FOR CANCER REGISTRARS Book 4 - Human Anatomy as Related to Tumor Formation Second Edition Prepared by: SEER Program Cancer Statistics Branch National Cancer Institute Editor in Chief: Evelyn M. Shambaugh, M.A., CTR Cancer Statistics Branch National Cancer Institute Assisted by Self-Instructional Manual Committee: Dr. Robert F. Ryan, Emeritus Professor of Surgery Tulane University School of Medicine New Orleans, Louisiana Mildred A. Weiss Los Angeles, California Mary A. Kruse Bethesda, Maryland Jean Cicero, ART, CTR Health Data Systems Professional Services Riverdale, Maryland Pat Kenny Medical Illustrator for Division of Research Services National Institutes of Health CONTENTS BOOK 4: HUMAN ANATOMY AS RELATED TO TUMOR FORMATION Page Section A--Objectives and Content of Book 4 ............................... 1 Section B--Terms Used to Indicate Body Location and Position .................. 5 Section C--The Integumentary System ..................................... 19 Section D--The Lymphatic System ....................................... 51 Section E--The Cardiovascular System ..................................... 97 Section F--The Respiratory System ....................................... 129 Section G--The Digestive System ......................................... 163 Section
  • 27 Lymph Vascular System

    27 Lymph Vascular System

    Lymph Vascular System The lymph vascular system consists of endothelial-lined tubes that recover intercellular (tissue) fluid not picked up by the blood vascular system and returns it to the blood. The fluid (lymph) carried by the lymphatics is a blood filtrate formed as fluid crosses the blood capillaries into the tissues. Unlike the blood vascular system, lymph flow is unidirectional - from tissues to the union of the lymphatic and blood vascular systems at the base of the neck. The lymphatic vascular system begins in the tissues as blindly ending capillaries that drain into larger collecting vessels and then into two main lymphatic trunks. Lymph nodes occur along the course of the vessels and filter the lymph. Lymphatics are present in most tissues but are absent from bone marrow, the central nervous system, coats of the eye, internal ear, and fetal placenta. Lymph Capillaries Lymph capillaries are thin-walled, blind tubes that branch and anastomose freely to form a rich network in organs and tissues. They are wider and more irregular than blood capillaries. The wall of a lymph capillary consists only of a thin continuous endothelium and a discontinuous basal lamina that is present only in patches or may even be absent. Adjacent endothelial cells may overlap, but junctional complexes are few and clefts occur between the cells. Externally, the endothelium is surrounded by a small amount of collagenous connective tissue. Fine filaments run perpendicularly from the collagen bundles and attach to the outer surfaces of the endothelium as anchoring filaments that maintain the patency of the vessel. Collecting Lymph Vessels Collecting lymph vessels differ from lymph capillaries in size and the thickness of their walls.
  • The Size of Lymph Nodes in the Neck on Sonograms As a Radiologic Criterion for Metastasis: How Reliable Is It?

    The Size of Lymph Nodes in the Neck on Sonograms As a Radiologic Criterion for Metastasis: How Reliable Is It?

    AJNR Am J Neuroradiol 19:695–700, April 1998 The Size of Lymph Nodes in the Neck on Sonograms as a Radiologic Criterion for Metastasis: How Reliable Is It? Michiel W. M. van den Brekel, Jonas A. Castelijns, and Gordon B. Snow PURPOSE: A definition of cut-off points for nodal size is essential to determine whether cervical lymph nodes are metastatic or not. Because the currently used size criteria are defined for random populations of patients with head and neck cancer, we set out to study whether these criteria are optimal for patients without palpable metastases in different levels of the neck. We defined optimal size criteria for sonography by calculating the sensitivity and specificity of different size cut-off points. METHODS: We compared the sensitivity and specificity of different size cut-off points as measured on sonograms for various levels in the neck in a series of 117 patients with and 131 patients without palpable neck metastases. RESULTS: A minimum axial diameter of 7 mm for level II and 6 mm for the rest of the neck revealed the optimal compromise between sensitivity and specificity in necks without palpable metastases. For all necks together (with and without palpable metastases), the criteria were 1 to 2 mm larger. CONCLUSION: Our findings indicate that the current sonographic size criteria used for random patient populations are not optimal for necks without palpable metastases, nor can the same cut-off points be used for all levels in the neck. The management of lymph node metastases in the cious lymph nodes may convert both selective neck neck in patients with squamous cell carcinoma of the treatment and a wait-and-see policy to more secure upper air and food passages is a continuing source of comprehensive treatment of all levels of the neck (6).
  • Brain-To-Cervical Lymph Node Signaling After Stroke

    Brain-To-Cervical Lymph Node Signaling After Stroke

    ARTICLE https://doi.org/10.1038/s41467-019-13324-w OPEN Brain-to-cervical lymph node signaling after stroke Elga Esposito1, Bum Ju Ahn1, Jingfei Shi1,2, Yoshihiko Nakamura 1,3, Ji Hyun Park1, Emiri T. Mandeville 1, Zhanyang Yu1, Su Jing Chan 1,4, Rakhi Desai1, Ayumi Hayakawa1, Xunming Ji2, Eng H. Lo1,5*& Kazuhide Hayakawa1,5* After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) 1234567890():,; pathway is involved. In rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferate and macrophages are rapidly activated in CLNs within 24 h, in part via VEGF-C/ VEGFR3 signalling. Microarray analyses of isolated lymphatic endothelium from CLNs of ischemic mice confirm the activation of transmembrane tyrosine kinase pathways. Blockade of VEGFR3 reduces lymphatic endothelial activation, decreases pro-inflammatory macro- phages, and reduces brain infarction. In vitro, VEGF-C/VEGFR3 signalling in lymphatic endothelial cells enhances inflammatory responses in co-cultured macrophages. Lastly, surgical removal of CLNs in mice significantly reduces infarction after focal cerebral ischemia. These findings suggest that modulating the brain-to-CLN pathway may offer therapeutic opportunities to ameliorate systemic inflammation and brain injury after stroke. 1 Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA. 2 China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China. 3 Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Jonan, Fukuoka, Japan.
  • Lymphatic Tissue Engineering and Regeneration Laura Alderfer1, Alicia Wei1 and Donny Hanjaya-Putra1,2,3,4,5,6*

    Lymphatic Tissue Engineering and Regeneration Laura Alderfer1, Alicia Wei1 and Donny Hanjaya-Putra1,2,3,4,5,6*

    Alderfer et al. Journal of Biological Engineering (2018) 12:32 https://doi.org/10.1186/s13036-018-0122-7 REVIEW Open Access Lymphatic Tissue Engineering and Regeneration Laura Alderfer1, Alicia Wei1 and Donny Hanjaya-Putra1,2,3,4,5,6* Abstract The lymphatic system is a major circulatory system within the body, responsible for the transport of interstitial fluid, waste products, immune cells, and proteins. Compared to other physiological systems, the molecular mechanisms and underlying disease pathology largely remain to be understood which has hindered advancements in therapeutic options for lymphatic disorders. Dysfunction of the lymphatic system is associated with a wide range of disease phenotypes and has also been speculated as a route to rescue healthy phenotypes in areas including cardiovascular disease, metabolic syndrome, and neurological conditions. This review will discuss lymphatic system functions and structure, cell sources for regenerating lymphatic vessels, current approaches for engineering lymphatic vessels, and specific therapeutic areas that would benefit from advances in lymphatic tissue engineering and regeneration. Keywords: Lymphangiogenesis, Tissue Engineering, Disease Modeling, Wound Healing, Lymphedema, Stem Cells, Biomaterials, Interstitial Fluid, Regeneration I. Introduction to the Lymphatic System and its role Interstitial fluid (IF) is a plasma filtrate that is generated Function by transcapillary filtration and is governed by Starling The lymphatic system is nearly ubiquitous in the human forces, the net difference between hydrostatic and body, present in all tissues except the epidermis, cartil- osmotic pressures, at the microcirculatory level [9]. In age, eye lens, cornea, retina, and bone marrow [1, 2]. order to maintain fluid homeostasis, lymph formation in The main functions of the lymphatic system include the initial lymphatic vessels must be balanced by the net fluid homeostasis and interstitial fluid drainage, immune flux of plasma being filtered out [4].
  • A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets

    A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets

    International Journal of Molecular Sciences Article A Role of Inflammation and Immunity in Essential Hypertension—Modeled and Analyzed Using Petri Nets Dorota Formanowicz 1 , Agnieszka Rybarczyk 2,3 , Marcin Radom 2,3 and Piotr Formanowicz 2,3,* 1 Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, 60-806 Poznan, Poland; [email protected] 2 Institute of Computing Science, Poznan University of Technology, 60-965 Poznan, Poland; [email protected] (A.R.); [email protected] (M.R.) 3 Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland * Correspondence: [email protected] Received: 15 April 2020; Accepted: 5 May 2020; Published: 9 May 2020 Abstract: Recent studies have shown that the innate and adaptive immune system, together with low-grade inflammation, may play an important role in essential hypertension. In this work, to verify the importance of selected factors for the development of essential hypertension, we created a Petri net-based model and analyzed it. The analysis was based mainly on t-invariants, knockouts of selected fragments of the net and its simulations. The blockade of the renin-angiotensin (RAA) system revealed that the most significant effect on the emergence of essential hypertension has RAA activation. This blockade affects: (1) the formation of angiotensin II, (2) inflammatory process (by influencing C-reactive protein (CRP)), (3) the initiation of blood coagulation, (4) bradykinin generation via the kallikrein-kinin system, (5) activation of lymphocytes in hypertension, (6) the participation of TNF alpha in the activation of the acute phase response, and (7) activation of NADPH oxidase—a key enzyme of oxidative stress.
  • Lymph and Lymphatic Vessels

    Lymph and Lymphatic Vessels

    Cardiovascular System LYMPH AND LYMPHATIC VESSELS Venous system Arterial system Large veins Heart (capacitance vessels) Elastic arteries Large (conducting lymphatic vessels) vessels Lymph node Muscular arteries (distributing Lymphatic vessels) system Small veins (capacitance Arteriovenous vessels) anastomosis Lymphatic Sinusoid capillary Arterioles (resistance vessels) Postcapillary Terminal arteriole venule Metarteriole Thoroughfare Capillaries Precapillary sphincter channel (exchange vessels) Copyright © 2010 Pearson Education, Inc. Figure 19.2 Regional Internal jugular vein lymph nodes: Cervical nodes Entrance of right lymphatic duct into vein Entrance of thoracic duct into vein Axillary nodes Thoracic duct Cisterna chyli Aorta Inguinal nodes Lymphatic collecting vessels Drained by the right lymphatic duct Drained by the thoracic duct (a) General distribution of lymphatic collecting vessels and regional lymph nodes. Figure 20.2a Lymphatic System Outflow of fluid slightly exceeds return Consists of three parts 1. A network of lymphatic vessels carrying lymph 1. Transports fluid back to CV system 2. Lymph nodes 1. Filter the fluid within the vessels 3. Lymphoid organs 1. Participate in disease prevention Lymphatic System Functions 1. Returns interstitial fluid and leaked plasma proteins back to the blood 2. Disease surveillance 3. Lipid transport from intestine via lacteals Venous system Arterial system Heart Lymphatic system: Lymph duct Lymph trunk Lymph node Lymphatic collecting vessels, with valves Tissue fluid Blood Lymphatic capillaries Tissue cell capillary Blood Lymphatic capillaries capillaries (a) Structural relationship between a capillary bed of the blood vascular system and lymphatic capillaries. Filaments anchored to connective tissue Endothelial cell Flaplike minivalve Fibroblast in loose connective tissue (b) Lymphatic capillaries are blind-ended tubes in which adjacent endothelial cells overlap each other, forming flaplike minivalves.
  • Lymphatic System Urls

    Lymphatic System Urls

    Lymphatic System URLs Human Anatomy & Physiology 16 http://www.howstuffworks.com/immune-system.htm http://www.thebody.com/step/immune.html http://www.emc.maricopa.edu/faculty/farabee/BIOBK/ BioBookIMMUN.html & http://www.cayuga-cc.edu/about/facultypages/greer/ r http://www.acm.uiuc.edu/sigbio/project/updated- lymphatic/lymph1.html http://www.pblsh.com/Healthworks/lymphart.html Karen Webb Smith Unit Fou Introduction A. The lymphatic system is closely associated with the cardiovascular system and is comprised of a network of vessels that circulate body fluids. B. Lymphatic vessels transport excess fluid away from interstitial spaces between cells in most tissues & return it to the bloodstream. C. Lymphatic vessels called lacteals (located in the in the lining of the smallsmall intestine) absorb fats resulting from digestion, & then transport fats to the circulatory system. D. The organs of the lymphatic system help defend Lymphatic vessels against disease. transporting fluid from interstitial spaces to the bloodstream Lymphatic Pathways A. Lymphatic pathways start as lymphatic capillaries that merge to form larger vessels that empty into the circulatory system. (This is key to understanding this chapter.) B. Lymphatic Capillaries *are microscopic, close-ended tubes that extend into interstitial spaces forming networks that parallel the networks of the blood capillaries *walls consist of single layer squamous epithelial cells which enables interstitial fluid to enter the lymphatic capillaries *lymph – the fluid inside a lymph capillary C. Lymphatic Vessels *walls of lymphatic vessels are thinner than walls of veins * have semilunar valves to prevent backflow of lymph *lymph nodes – specialized lymph organs that are composed of a mass of lymphoid tissue located along the course of a lymphatic vessel D.