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Five Tyrosines and Two Serines in Human Albumin Are Labeled by the Organophosphorus Agent FP-Biotin
View metadata, citation and similar papers at core.ac.uk brought to you by CORE Chem. Res. Toxicol. 2008, 21, 1787–1794 1787 provided by PubMed Central Five Tyrosines and Two Serines in Human Albumin Are Labeled by the Organophosphorus Agent FP-Biotin Shi-Jian Ding,† John Carr,† James E. Carlson,‡ Larry Tong,§ Weihua Xue,§ Yifeng Li,† Lawrence M. Schopfer,§ Bin Li,§ Florian Nachon,| Oluwatoyin Asojo,† Charles M. Thompson,⊥ Steven H. Hinrichs,† Patrick Masson,| and Oksana Lockridge*,§ Department of Pathology and Microbiology, UniVersity of Nebraska Medical Center, Omaha, Nebraska 68198, Applied Biosystems, Framingham, Massachusetts 01701, Eppley Institute, UniVersity of Nebraska Medical Center, Omaha, Nebraska 68198, Centre de Recherches d SerVice de Sante´ des Arme´es, Unite´ d’Enzymologie, BP87, 38702 La Tronche Cedex, France, and Department of Biomedical and Pharmaceutical Sciences, UniVersity of Montana, Missoula, Montana 59812 ReceiVed April 23, 2008 Tyrosine 411 of human albumin is an established site for covalent attachment of 10-fluoroethoxyphosphinyl- N-biotinamidopentyldecanamide (FP-biotin), diisopropylfluorophosphate, chlorpyrifos oxon, soman, sarin, and dichlorvos. This work investigated the hypothesis that other residues in albumin could be modified by organophosphorus agents (OP). Human plasma was aggressively treated with FP-biotin; plasma proteins were separated into high and low abundant portions using a proteome partitioning antibody kit, and the proteins were digested with trypsin. The FP-biotinylated tryptic peptides were isolated by binding to monomeric avidin beads. The major sites of covalent attachment identified by mass spectrometry were Y138, Y148, Y401, Y411, Y452, S232, and S287 of human albumin. Prolonged treatment of pure human albumin with chlorpyrifos oxon labeled Y138, Y150, Y161, Y401, Y411, and Y452. -
2018 Annual Survey of Biological and Chemical Agents Regulated by Homeland Security (And Carcinogens Regulated by OSHA)
Name: Dept: Date: 2018 Annual Survey of Biological and Chemical Agents regulated by Homeland Security (and carcinogens regulated by OSHA) Due (date) All labs that do not have a current chemical inventory in Chematix MUST complete this survey. The University is required to make an annual report of all chemicals on the Chemical Facility Anti-Terrorism Standards (CFATS) lists. Additional information regarding the regulations is available on the EH&S website at http://www.safety.rochester.edu/restricted/occsafe/chemicalagent.html and https://www.selectagents.gov. 1. Please review the lists on the following pages and indicate if any are possessed by your lab. The CAS# has been added to the list for ease of searching databases. The CAS# is a Chemical Abstract Service numbering system which assigns a unique number to every chemical substance based on structure; this helps avoid confusion by use of synonyms or different naming conventions. a. If yes for possession, place an X in the applicable box and if requested, include the quantity held in your lab. b. If no, leave blank. 2. After reviewing the list, please complete the information box below (or on last page for possession), then sign, date and return to EH&S. 3. Please call Donna Douglass at 275-2402 if you have any questions. Thank you for your cooperation in collecting data required by the Department of Homeland Security! Possession: 1) Fill in applicable boxes, 2) have PI sign last page, 3) return all pages to Donna Douglass OR Non-possession: 1) Check only one box on the left, 2) sign, 3) return just this page to Donna Douglass I do not have a lab, do not work in a lab, nor do I possess any of the agents in this survey. -
Chemical Chemical Hazard and Compatibility Information
Chemical Chemical Hazard and Compatibility Information Acetic Acid HAZARDS & STORAGE: Corrosive and combustible liquid. Serious health hazard. Reacts with oxidizing and alkali materials. Keep above freezing point (62 degrees F) to avoid rupture of carboys and glass containers.. INCOMPATIBILITIES: 2-amino-ethanol, Acetaldehyde, Acetic anhydride, Acids, Alcohol, Amines, 2-Amino-ethanol, Ammonia, Ammonium nitrate, 5-Azidotetrazole, Bases, Bromine pentafluoride, Caustics (strong), Chlorosulfonic acid, Chromic Acid, Chromium trioxide, Chlorine trifluoride, Ethylene imine, Ethylene glycol, Ethylene diamine, Hydrogen cyanide, Hydrogen peroxide, Hydrogen sulfide, Hydroxyl compounds, Ketones, Nitric Acid, Oleum, Oxidizers (strong), P(OCN)3, Perchloric acid, Permanganates, Peroxides, Phenols, Phosphorus isocyanate, Phosphorus trichloride, Potassium hydroxide, Potassium permanganate, Potassium-tert-butoxide, Sodium hydroxide, Sodium peroxide, Sulfuric acid, n-Xylene. Acetone HAZARDS & STORAGE: Store in a cool, dry, well ventilated place. INCOMPATIBILITIES: Acids, Bromine trifluoride, Bromine, Bromoform, Carbon, Chloroform, Chromium oxide, Chromium trioxide, Chromyl chloride, Dioxygen difluoride, Fluorine oxide, Hydrogen peroxide, 2-Methyl-1,2-butadiene, NaOBr, Nitric acid, Nitrosyl chloride, Nitrosyl perchlorate, Nitryl perchlorate, NOCl, Oxidizing materials, Permonosulfuric acid, Peroxomonosulfuric acid, Potassium-tert-butoxide, Sulfur dichloride, Sulfuric acid, thio-Diglycol, Thiotrithiazyl perchlorate, Trichloromelamine, 2,4,6-Trichloro-1,3,5-triazine -
Chemical Name Federal P Code CAS Registry Number Acutely
Acutely / Extremely Hazardous Waste List Federal P CAS Registry Acutely / Extremely Chemical Name Code Number Hazardous 4,7-Methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro- P059 76-44-8 Acutely Hazardous 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide P050 115-29-7 Acutely Hazardous Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- P197 17702-57-7 Acutely Hazardous 1-(o-Chlorophenyl)thiourea P026 5344-82-1 Acutely Hazardous 1-(o-Chlorophenyl)thiourea 5344-82-1 Extremely Hazardous 1,1,1-Trichloro-2, -bis(p-methoxyphenyl)ethane Extremely Hazardous 1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta (cd) pentalene, Dechlorane Extremely Hazardous 1,1a,3,3a,4,5,5,5a,5b,6-Decachloro--octahydro-1,2,4-metheno-2H-cyclobuta (cd) pentalen-2- one, chlorecone Extremely Hazardous 1,1-Dimethylhydrazine 57-14-7 Extremely Hazardous 1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4,4a,5,6,7,8,8a-octahydro-1,4-endo-endo-5,8- dimethanonaph-thalene Extremely Hazardous 1,2,3-Propanetriol, trinitrate P081 55-63-0 Acutely Hazardous 1,2,3-Propanetriol, trinitrate 55-63-0 Extremely Hazardous 1,2,4,5,6,7,8,8-Octachloro-4,7-methano-3a,4,7,7a-tetra- hydro- indane Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]- 51-43-4 Extremely Hazardous 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, P042 51-43-4 Acutely Hazardous 1,2-Dibromo-3-chloropropane 96-12-8 Extremely Hazardous 1,2-Propylenimine P067 75-55-8 Acutely Hazardous 1,2-Propylenimine 75-55-8 Extremely Hazardous 1,3,4,5,6,7,8,8-Octachloro-1,3,3a,4,7,7a-hexahydro-4,7-methanoisobenzofuran Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime 26419-73-8 Extremely Hazardous 1,3-Dithiolane-2-carboxaldehyde, 2,4-dimethyl-, O- [(methylamino)-carbonyl]oxime. -
Table II. EPCRA Section 313 Chemical List for Reporting Year 2017 (Including Toxic Chemical Categories)
Table II. EPCRA Section 313 Chemical List For Reporting Year 2017 (including Toxic Chemical Categories) Individually listed EPCRA Section 313 chemicals with CAS numbers are arranged alphabetically starting on page II-3. Following the alphabetical list, the EPCRA Section 313 chemicals are arranged in CAS number order. Covered chemical categories follow. Note: Chemicals may be added to or deleted from the list. The Emergency Planning and Community Right-to-Know Call Center or the TRI-Listed Chemicals website will provide up-to-date information on the status of these changes. See section B.3.c of the instructions for more information on the de minimis % limits listed below. There are no de minimis levels for PBT chemicals since the de minimis exemption is not available for these chemicals (an asterisk appears where a de minimis limit would otherwise appear in Table II). However, for purposes of the supplier notification requirement only, such limits are provided in Appendix C. Chemical Qualifiers Certain EPCRA Section 313 chemicals listed in Table II have parenthetic “qualifiers.” These qualifiers indicate that these EPCRA Section 313 chemicals are subject to the section 313 reporting requirements if manufactured, processed, or otherwise used in a specific form or when a certain activity is performed. An EPCRA Section 313 chemical that is listed without a qualifier is subject to reporting in all forms in which it is manufactured, processed, and otherwise used. The following chemicals are reportable only if they are manufactured, processed, or otherwise used in the specific form(s) listed below: Chemical/ Chemical Category CAS Number Qualifier Aluminum (fume or dust) 7429-90-5 Only if it is a fume or dust form. -
Ttl Iii26 (C) 28
USOO6610977B2 (12) United States Patent (10) Patent No.: US 6,610,977 B2 Megerle (45) Date of Patent: Aug. 26, 2003 (54) SECURITY SYSTEM FOR NBC-SAFE 5,692,029 A 11/1997 Husseiny et al. BUILDING 5,692,446 A 12/1997 Becker et al. 5,866.430 A 2/1999 Grow (75) Inventor: Clifford Megerle, Manassas, VA (US) 5,915,268 A 6/1999 Linker et al. 5,965,882 A 10/1999 Megerle et al. (73) Assignee: Lockheed Martin Corporation, 6,073,499 A 6/2000 Settles Bethesda, MD (US) 6,100,698 A 8/2000 Megerle et al. OTHER PUBLICATIONS * ) Notice: Subject to anyy disclaimer, the term of this patent is extended or adjusted under 35 U.S. Pub: 2003/0009661 A1, “Security System and Method U.S.C. 154(b) by 53 days. of Security Service Business”, Tsutsumi et al. (Jan. 9, 2003 ).* (21) Appl. No.: 09/969,050 * cited by examiner (22) Filed: Oct. 1, 2001 Primary Examiner John R. Lee O O ASSistant Examiner Zia R. Hashmi (65)65 PriorO PublicationCaO Data (74) Attorney, Agent, or Firm-Simpson & Simpson, PLLC US 2003/0085348 A1 May 8, 2003 (57) ABSTRACT (51) Int. Cl." ................................................ G01N 23/00 (52) U.S. Cl. ........................ 250,287: 250/286, 73,232. A method and apparatus for Screening an object for the 73/28.01, 73/23; 7323,36. 37s'ss. 37ss6. presence of an explosive, chemical warfare agent, biological s s s 37s?is6 warfare agent, drug, metal, weapon, and/or radioactive (58) Field of Search 250/287, 286; material. -
Chlorine Trifluoride Ctf
CHLORINE TRIFLUORIDE CTF CAUTIONARY RESPONSE INFORMATION 4. FIRE HAZARDS 7. SHIPPING INFORMATION 4.1 Flash Point: 7.1 Grades of Purity: 99+% Common Synonyms Liquefied compressed Greenish yellow liquid Strong sweetish Not flammable, but may cause fire on 7.2 Storage Temperature: Ambient CTF gas or colorless gas odor contact with some materials. 7.3 Inert Atmosphere: No requirement 4.2 Flammable Limits in Air: Not pertinent 7.4 Venting: Safety relief Sinks and may boil in water. Reacts violently with water to produce 4.3 Fire Extinguishing Agents: Dry chemical 7.5 IMO Pollution Category: Currently not available poisonous gas. Boiling point is 53°F. 4.4 Fire Extinguishing Agents Not to Be Used: Do not use water on adjacent fires 7.6 Ship Type: Currently not available KEEP PEOPLE AWAY. AVOID CONTACT WITH LIQUID AND VAPOR. unless well protected against hydrogen 7.7 Barge Hull Type: Currently not available Avoid inhalation. fluoride gas. Wear chemical protective suit with self-contained breathing apparatus. 4.5 Special Hazards of Combustion Evacuate area in case of large discharge. Products: If released from container, 8. HAZARD CLASSIFICATIONS Call fire department. fumes are toxic and irritating. 8.1 49 CFR Category: Poison Gas Notify local health and pollution control agencies. 4.6 Behavior in Fire: If released from 8.2 49 CFR Class: 2.3 Protect water intakes. container, can increase the intensity of 8.3 49 CFR Package Group: Not pertinent. fire. Containers may explode. Not flammable. 8.4 Marine Pollutant: No Fire May explode on contact with combustibles. 4.7 Auto Ignition Temperature: Not pertinent 8.5 NFPA Hazard Classification: Not listed POISONOUS GASES ARE PRODUCED WHEN HEATED. -
SUMMARY of PARTICULARLY HAZARDOUS SUBSTANCES (By
SUMMARY OF PARTICULARLY HAZARDOUS SUBSTANCES (by alpha) Key: SC -- Select Carcinogens RT -- Reproductive Toxins AT -- Acute Toxins SA -- Readily Absorbed Through the Skin DHS -- Chemicals of Interest Revised: 11/2012 ________________________________________________________ ___________ _ _ _ _ _ _ _ _ _ _ _ ||| | | | CHEMICAL NAME CAS # |SC|RT| AT | SA |DHS| ________________________________________________________ ___________ | _ | _ | _ | _ | __ | | | | | | | 2,4,5-T 000093-76-5 | | x | | x | | ABRIN 001393-62-0 | | | x | | | ACETALDEHYDE 000075-07-0 | x | | | | | ACETAMIDE 000060-35-5 | x | | | | | ACETOHYDROXAMIC ACID 000546-88-3 ||x| | x | | ACETONE CYANOHYDRIN, STABILIZED 000075-86-5 | | | x | | x | ACETYLAMINOFLUORENE,2- 000053-96-3 | x | | | | | ACID MIST, STRONG INORGANIC 000000-00-0 | x | | | | | ACROLEIN 000107-02-8 | | x | x | x | | ACRYLAMIDE 000079-06-1 | x | x | | x | | ACRYLONITRILE 000107-13-1 | x | x | x | x | | ACTINOMYCIN D 000050-76-0 ||x| | x | | ADIPONITRILE 000111-69-3 | | | x | | | ADRIAMYCIN 023214-92-8 | x | | | | | AFLATOXIN B1 001162-65-8 | x | | | | | AFLATOXIN M1 006795-23-9 | x | | | | | AFLATOXINS 001402-68-2 | x | | x | | | ALL-TRANS RETINOIC ACID 000302-79-4 | | x | | x | | ALPRAZOMAN 028981-97-7 | | x | | x | | ALUMINUM PHOSPHIDE 020859-73-8 | | | x | | x | AMANTADINE HYDROCHLORIDE 000665-66-7 | | x | | x | | AMINO-2,4-DIBROMOANTHRAQUINONE 000081-49-2 | x | | | | | AMINO-2-METHYLANTHRAQUINONE, 1- 000082-28-0 | x | | | | | AMINO-3,4-DIMETHYL-3h-IMIDAZO(4,5f)QUINOLINE,2- 077094-11-2 | x | | | | | AMINO-3,8-DIMETHYL-3H-IMIDAZO(4,5-f)QUINOXALINE, -
Department of Homeland Security Chemicals of Interest
Department of Homeland Security Chemicals of Interest On October 4, 2006, President George W Bush signed the Homeland Security Appropriations Act of 2007. This Act gave the Department of Homeland Security (DHS) authority to regulate the security of facilities that contain high risk chemicals. On April 9, 2007, the Department of Homeland Security issued the Chemical Facility Anti- Terrorism Standards (CFATS). Under these standards the University must maintain an inventory of chemicals that are subject to this regulation. The chemicals subject to this regulation are more commonly known as chemicals of interest or COIs. In order to ensure the University of Northern Iowa remains compliant with this regulation, departments who come into possession of any of the chemicals listed on the following pages must immediately inform the Environmental Health and Safety (EH&S) Office of the name of the chemical or chemicals that were acquired, their respective amounts and storage location. Departments must also submit annual inventories of their chemicals to the EH&S office so an annual review of the amounts of COIs the University has on campus can be completed. If at any time it is found the amount of one or more of the COIs on campus exceeds the regulatory level (designated as threshold quantity by the DHS), the University must submit a report to the Department of Homeland Security (referred to as a “Top-Screen” by the DHS) within 60 days. Failure to report this information could result in fines to the University of $25,000 per day. The EH&S Office is responsible for gathering of campus chemical information and for submitting the Top Screen Report to the Department of Homeland Security on behalf of the University. -
National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances Report Run Date: 09/26/2021 04:22:31 PM 1
2008 Current Fiscal Year Report: National Advisory Committee for Acute Exposure Guideline Levels for Hazardous Substances Report Run Date: 09/26/2021 04:22:31 PM 1. Department or Agency 2. Fiscal Year Environmental Protection Agency 2008 3b. GSA 3. Committee or Subcommittee Committee No. National Advisory Committee for Acute Exposure Guideline Levels 2073 for Hazardous Substances 4. Is this New During Fiscal 5. Current 6. Expected Renewal 7. Expected Term Year? Charter Date Date No 11/02/2007 11/02/2009 8a. Was Terminated During 8b. Specific Termination 8c. Actual Term FiscalYear? Authority Date No 9. Agency Recommendation for Next10a. Legislation Req to 10b. Legislation FiscalYear Terminate? Pending? Continue 11. Establishment Authority Agency Authority 12. Specific Establishment 13. Effective 14. Commitee 14c. Authority Date Type Presidential? AGEN 09/28/1995 Continuing No 15. Description of Committee Scientific Technical Program Advisory Board 16a. Total Number of Reports 16 16b. Report Date Report Title 10/01/2007 Final Acute Exposure Guideline Levels for Chlorine Dioxide 10/01/2007 Final Acute Exposure Guideline Levels for Chlorine Trifluoride 10/01/2007 Final Acute Exposure Guideline Levels for Cyclohexylamine 10/01/2007 Final Acute Exposure Guideline Levels for Ethylenediamine 10/01/2007 Final Acute Exposure Guideline Levels for Hydrofluoroether-7100 10/01/2007 Final Acute Exposure Guideline Levels for Tetranitromethane 04/01/2008 Final Acute Exposure Guideline Levels for Allylamine 04/01/2008 Final Acute Exposure Guideline Levels -
Department of Homeland Security (Dhs) Appendix a Chemicals of Interest (Coi)
DEPARTMENT OF HOMELAND SECURITY (DHS) APPENDIX A CHEMICALS OF INTEREST (COI) Acetaldehyde Bromine trifluoride Acetone Cyanohydrin, stabilized Bromothrifluorethylene Acetyl bromide 1,3-Butadiene Acetyl chloride Butane Acetyl iodide Butene Acetylene 1-Butene Acrolein 2-Butene Acrylonitrile 2-Butene-cis Acrylyl chloride 2-Butene-trans Allyl alcohol Butyltrichlorosilane Allylamine Calcium hydrosulfite Allyltrichlorosilane, stabilized Calcium phosphide Aluminum (powder) Carbon disulfide Aluminum Bromide, anhydrous Carbon oxysulfide Aluminum Chloride, anhydrous Carbonyl fluoride Aluminum phosphide Carbonyl sulfide Ammonia (anhydrous) Chlorine Ammonia (conc 20% or greater) Chlorine dioxide Ammonium nitrate, note #1 Chlorine monoxide Ammonium nitrate, note #2 Chlorine pentafluoride Ammonium perchlorate Chlorine trifluoride Ammonium picrate Chloroacetyl chloride Amyltrichlorosilane 2-Chloroethylchloro-methylsulfide Antimony pentafluoride Chloroform Arsenic trichloride Chloromethyl ether Arsine Chloromethyl methyl ether Barium azide 1-Chloropropylene 1,4-Bis(2-chloroethylthio)-n-butane 2-Chloropropylene Bis(2-chloroethylthio) methane Chlorosarin Bis(2-chloroethylthiomethyl)ether Chlorosoman 1,5-Bis(2-chloroethylthio)-n-pentane Chlorosulfonic acid 1,3-Bis(2-chloroethylthio)-n-propane Chromium oxychloride Boron tribromide Crotonaldehyde Boron trichloride Crotonaldehyde, (E)- Boron trifluoride Cyanogen Boron trifluoride compound with methyl Cyanogen chloride ether (1:1) Cyclohexylamine Bromine Cyclohexyltrichlorosilane Bromine chloride Cyclopropane -
Homeland Security List
List Sorted Alphabetically ACG = Any Commercial Grade. If you have any questions, please contact EHS @ 898-5126. Minimum Concentration Chemical Of Interest Synonym CAS (percent) Amount on Hand (pounds) 1- Pentene 109-67-1 1 1,1-Dimethylhydrazine [Hydrazine, 1, 1-dimethyl-] 57-14-7 1 1,3-Bis(2-chloroethylthio)-n-propane 63905-10-2 any quantity 1,3-Butadiene 106-99-0 1 1,3-Pentadiene 504-60-9 1 1,4-Bis(2-chloroethylthio)-n-butane 142868-93-7 any quantity 1,5-Bis(2-chloroethylthio)-n-pentane 142868-94-8 any quantity 1-Butene 106-98-9 1 1-Chloropropylene [1-Propene, 1-chloro-] 590-21-6 1 1H-Tetrazole 288-94-8 ACG 2,2-Dimethylpropane [Propane, 2,2-dimethyl-] 463-82-1 1 2-Butene 107-01-7 1 2-Butene-cis 590-18-1 1 2-Butene-trans [2-Butene, (E)] 624-64-6 1 2-Chloroethylchloro-methylsulfide 2625-76-5 any quantity 2-Chloropropylene [1-Propene, 2-chloro-] 557-98-2 1 2-Methyl-1-butene 563-46-2 1 2-Methylpropene [1-Propene, 2-methyl-] 115-11-7 1 2-Pentene, (E)- 646-04-8 1 2-Pentene, (Z)- 627-20-3 1 3-Methyl-1-butene 563-45-1 1 5-Nitrobenzotriazol 2338-12-7 ACG Acetaldehyde 75-07-0 1 Acetylene [Ethyne] 74-86-2 1 Acrolein [2-Propenal] or Acrylaldehyde 107-02-8 1 Acrylonitrile [2-Propenenitrile] 107-13-1 1 Acrylyl chloride [2-Propenoyl chloride] 814-68-6 1 Allyl alcohol [2-Propen-1-ol] 107-18-6 1 Allylamine [2-Propen-1-amine] 107-11-9 1 Aluminum (powder) 7429-90-5 ACG Ammonia (anhydrous) 7664-41-7 1 Ammonia (conc.