Pathology Mcqs by Dr Asif Khan
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B. Cells which are not able to express MHC1 C. MHC cells which express MHC2 D. Cells which are not able to express MHC Pathology mcqs Key: B 1. Function of CD4 is all except: 7. The following interleukin is characteristically A. Memory produced in a TH1 response: B. Immunoglobin production A. IL-2 C. Activation of macrophages B. IL-4 D. Cytotoxicity C. IL-5 D. IL-10 Key: B Key: A 2. A super-antigen is a bacterial product that A. Binds to B7 and CD28 co-stimulatory molecules 8. CD-95 has a major role in: B. Binds to the beta chain of TCR and MHC class II A. Apoptosis molecules of APC stimulating T cell activation B. Cell necrosis C. Binds to the CD4 + molecule causing T cell C. Interferon activation activation D. Proteolysis D. Is presented by macrophages to a larger-than- normal number of helper CD4 + lymphocytes Key: A Key: B 9. The complement is fixed best by which of the following immunoglobulins: 3. All of the following statements about NK cells are A. IgG true except: B. IgM A. They are derived from large granular cells C. IgA B. They comprise about 5% of human peripheral D. IgD lymphoid cells C. They are MHC restricted cytotoxic cells Key: B D. They express IgG Fc receptors 10. Antigen presenting cells are which of the following: Key: C A. Astrocytes B. Endothelial cells 4. The following feature is common to both cytotoxic T- C. Epithelial cells cells and NK cells: D. Langerhan’s cells A. Synthesize antibody B. Require antibodies to be present for action Key: B C. Effective against virus infected cells D. Recognize antigen in association with HLA class 11. Antigen presenting cells are: II markers A. Langerhan’s cell B. Macrophage Key: C C. Cytotoxic T cells D. Helper T cells 5. Most potent stimulator of naive T cell is? E. B lymphocyte A. Mature dendritic cell B. Follicular dendritic cell Key: A C. Macrophages D. B cell 12. Perforins are produced by: A. Cytotoxic T cells Key: A B. Suppressor T cells C. Memory helper T cells 6. Natural killer cells attacks which of the following D. NK cells cells: A. Cells which express MHC1 Key: A 1 13. Marker for B-Lymphocyte: 20. NK cell CD marker is: A. CD34 (a) 16 B. CD33 (b) 60 C. CD19 (c) 32 D. CD20 (d) 25 Key: C Key: A 14. IL-1 causes 21. Immunity against cancer cells: A. Increased leukocyte adherence A. Basophills B. Fibroblast proliferation B. Eosinophils C. Increased collagen synthesis C. NK cells D. All of the above D. Neutrophils Key: D Key: C 15. Antigen presenting cells present in skin are called 22. NK cells express: A. Langerhan’s cells A. CD 15, CD 55 B. Kupffer’s cells B. CD 16, CD 56 C. Microglia C. CD 16, CD 57 D. Melanocytes D. CD 21, CD 66 Key: A Key: B 16. Plasma cells 23. Which of the following immune cells have the A. Contain nucleus expression of CD8 on their surface? B. Helps in the formation of antibody A. T-cells C. Are deficient in cytoplasm B. B-cells D. Are derived from T-cells C. Null cells D. Macrophages Key: B Key: A 17. The normal ratio of CD4 to CD8 is A. 1: 1 24. Macroglobulin is derived from: B. 2: 1 A. B cells C. 8: 1 B. T cells D. 10: 1 C. Both D. Natural killer cells Key: B Key: A 18. CD4 cells is used to identify which of the following A. MHC I 25. Kupffer cells are found in: B. MHC II A. Heart C. T cells B. Lungs D. B cells C. Liver D. Spleen Key: C Key: C 19. CD3 is marker for: A. Monocyte 26. Birbeck granules are present in B. T cell A. Merkel cell C. B cell B. Langerhans cell D. none C. Langhans cell D. Melanocyte Key: B 2 Key: B Key: A 27. MHC class III genes encode: A. Complement component C3 34. Antigen presented along with HLA class II stimulate B. Tumor necrosis factor A. CD8 cell C. Interleukin 2 B. CD4 cell D. Beta 2 microglobulin C. CD2 cell D. CD19 cell Key: B Key: B 28. The HLA class III region genes are important elements in: 35. Major histocompatibility complex class I is seen on A. Transplant rejection phenomenon which of the following cell? B. Governing susceptibility to autoimmune diseases A. Macrophages only C. Immune surveillance B. All body cells D. Antigen presentation and elimination C. B cell only D. All blood cells except erythrocytes Key: B Key: D 29. HLA is located on: A. Long arm of chromosome 6 36. What type of hypersensitivity reaction is seen in B. Long arm of chromosome 3 myasthenia gravis? C. Short arm of chromosome 6 A. Type 1 hypersensitivity reaction D. Short arm of chromosome 3 B. Type 2 hypersensitivity reaction C. Type 3 hypersensitivity reaction Key: C D. Type 4 hypersensitivity reaction 30. HLA B27 is positive in: Key: B A. Ankylosing spondylitis B. Rheumatoid arthritis 37. Hemolytic disease of newborn is an example of: C. SLE A. Type 3 hypersensitivity reaction D. Behçet syndrome B. Type 2 hypersensitivity reaction C. Arthus reaction Key: A D. Type 4 hypersensitivity reaction 31. Mixed lymphocyte culture is used to identify: Key: B A. MHC class I antigen B. MHC class II antigen 38. Raji cell assays are used to quantitate: C. B lymphocytes A. Complement levels D. T helper cells B. Immune complexes C. T cells Key: B D. Interferon levels 32. HLA typing is useful in: Key: B A. Disputed paternity B. Thanatology 39. Hypersensitivity pneumonitis is classically a/an: C. Organ transplant A. Allergic reaction D. Dactylography B. Type II hypersensitivity C. Immune complex mediated hypersensitivity Key: A D. Cell mediated hypersensitivity 33. Epitope binding floor of the MHC molecule conists of Key: C A. Alpha helices B. Beta pleated structure 40. The immunoglobulin involved in type I C. Alpha and beta-1 chain hypersensitivity reaction is: D. Beta-2 microglobin A. IgE 3 B. IgM 46. Which of the following diseases is/are C. IgA mediatedthrough complement activation: D. IgG (a) Atopic dermatitis (b) Graft versus Host disease Key: A (c) Photoallergy (d) Necrotizing vasculitis 41. Arthus reaction is what type of hypersensitivity (e) Urticaria reaction: A. Localized immune complex Key: D B. Ag-Ab reaction C. Complement mediated 47. Which of following statements is not true about D. Ab mediated Mycobacterium tuberculosis infection? A. M. tuberculosis leads to development of delayed Key: A hypersensitivity B. Lymphocytes are the primary cells infected by M. 42. A 40 year old man has chronic cough with fever for tuberculosis several months. The chest radiograph reveals a diffuse C. Positive tuberculin test signifies cell mediated reticulondular pattern. Microscopically on hypersensitivity transbronchial biopsy there are focal areas of D. Tuberculin test does not differentiate between inflammation containing epitheloid cell granuloma, infection and disease. Langhans giant cells, and lymphocytes. These findings are typical for which of the following type of Key: B hypersensitivity immunologic responses: A. Type I 48. A man after consuming sea food develops rashes. It is B. Type II due to: C. Type III A. IgE mediated response D. Type IV B. Complement activation C. Cell mediated response Key: D D. None of the above 43. Patient presented with generalized edema sweating Key: A and flushing tachycardia and fever after bee sting. This is: 49. Granuloma in Sarcoidosis is called A. T cell mediated cytotoxicity A. Hard sore B. IgE mediated reaction B. Soft sore C. IgG mediated reaction C. Hard tubercle D. IgA mediated hypersensitivity reaction D. Caseating granuloma Key: B Key: A 44. Example of Type IV Hypersensitivity is/are: 50. Myasthenia gravis may be associated with A. Farmer’s lung A. Thymoma B. Contact hypersensitivity B. Systemic lupus erythematosus C. Immediate hypersensitivity C. Hyperthyroidism D. Myasthenia gravis D. All of the above Key: B Key: D 45. Example of Type II Hypersensitivity is/are: 51. Which of the following type of hypersensitivity A. Blood transfusion reaction reaction is found in blood transfusion reaction? B. Arthus reaction A. Anaphylactic type C. Hay Fever B. Cytotoxic type D. Post-streptococcal glomerulonephritis C. Type III hypersensitivity D. Cell mediated hypersensitivity Key: A Key: B 4 C. Liver 52. Which of the following type of hypersensitivity D. Lung reactions occurs in Farmer’s lung A. Type I Key: D B. Type II C. Type III 59. Preformed antibodies cause: D. Type IV A. Hyperacute rejection B. Acute rejection Key: D C. Chronic rejection D. Acute humoral rejection 53. Tuberculin test positivity indicates A. Good humoral immunity Key: A B. Infection with mycobacterium C. Good cell mediated immunity 60. True about graft versus host disease is: D. None A. Associated with solid organ transplantation B. Graft must contains immunocompetent T cell Key: C C. It is seen in immunosuppressed persons D. Also called as Runt disease in animals 54. Myasthenia gravis is most commonly associated with which of the following? Key: A A. Thymoma B. Thymic carcinoma 61. Acute humoral renal transplant rejection is C. Thymic hyperplasia characterized by the following, except: D. Lymphoma A. Presence of anti-donor antibodies B. Interstitial and tubular mononuclear cell infiltrate Key: C C. Necrotizing vasculitis D. Acute cortical necrosis 55. Cell mediated immunity is: A. Type I Key: B B. Type II C. Type III 62. Transfer of the graft of different species are called as D. Type IV A. Isograft B. Allograft Key: D C.