Colour Atlas of Tropical Dermatology and Venerology
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Clinicopathological Features of Annular Elastolytic Giant Cell
Original Investigation / Özgün Araştırma Turk J Dermatol 2018;12:85-9 • DOI: 10.4274/tdd.3409 85 Hilal Kaya Clinicopathological Features of Annular Erdoğan, Deniz Arık*, Elastolytic Giant Cell Granuloma Patients Ersoy Acer, Evrim Yılmaz*, Anüler Elastolitik Dev Hücreli Granülom Zeynep Nurhan Hastalarının Klinikopatolojik Özellikleri Saraçoğlu Abstract Objective: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous disease characterized by annular plaques. In this study, we aimed to describe the clinical and pathological features of the patients diagnosed with AEGCG. Methods: The demographic, clinical and pathological features of patients who diagnosed with AEGCG were recorded retrospectively. Results: Ten patients with AEGCG included in the study (nine females and one male). The mean age of the patients was 60±9.53 years. The mean duration of disease was 24.2±36.30 months. On dermatologic examination, multiple, well-demarcated, elevated borders and central atrophic erythematous annular plaques were seen in all patients. In the most of the patients (90%) lesions were on the sun-exposed regions. Six of the patients had accompanying diseases. Histopathologic examination of the punch biopsies revealed foreign body type multinucleated giant cells and lymphocytic cell infiltration in the dermis. There were intracellular elastic fiber fragments as sign of elastophagocytosis in the giant cells. Conclusion: AEGCG is a rare granulomatous disease which can accompany various diseases. There is debate on the terminology, classification and pathogenesis. Further studies are required to elucidate the unknowns. Keywords: Annular elastolytic giant cell granuloma, elastophagocytosis, granulomatous diseases, elastolysis, giant cell, granuloma annulare Eskişehir Osmangazi University Faculty of Medicine, Öz Department of Dermatology and Venereology, Amaç: Anüler elastolitik dev hücreli granülom (AEDHG), anüler plaklar ile karakterize, Eskişehir, Turkey nadir granülomatöz bir hastalıktır. -
Melanocytes and Their Diseases
Downloaded from http://perspectivesinmedicine.cshlp.org/ on October 2, 2021 - Published by Cold Spring Harbor Laboratory Press Melanocytes and Their Diseases Yuji Yamaguchi1 and Vincent J. Hearing2 1Medical, AbbVie GK, Mita, Tokyo 108-6302, Japan 2Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Correspondence: [email protected] Human melanocytes are distributed not only in the epidermis and in hair follicles but also in mucosa, cochlea (ear), iris (eye), and mesencephalon (brain) among other tissues. Melano- cytes, which are derived from the neural crest, are unique in that they produce eu-/pheo- melanin pigments in unique membrane-bound organelles termed melanosomes, which can be divided into four stages depending on their degree of maturation. Pigmentation production is determined by three distinct elements: enzymes involved in melanin synthesis, proteins required for melanosome structure, and proteins required for their trafficking and distribution. Many genes are involved in regulating pigmentation at various levels, and mutations in many of them cause pigmentary disorders, which can be classified into three types: hyperpigmen- tation (including melasma), hypopigmentation (including oculocutaneous albinism [OCA]), and mixed hyper-/hypopigmentation (including dyschromatosis symmetrica hereditaria). We briefly review vitiligo as a representative of an acquired hypopigmentation disorder. igments that determine human skin colors somes can be divided into four stages depend- Pinclude melanin, hemoglobin (red), hemo- ing on their degree of maturation. Early mela- siderin (brown), carotene (yellow), and bilin nosomes, especially stage I melanosomes, are (yellow). Among those, melanins play key roles similar to lysosomes whereas late melanosomes in determining human skin (and hair) pigmen- contain a structured matrix and highly dense tation. -
Frequency of Different Types of Facial Melanoses Referring to the Department of Dermatology and Venereology, Nepal Medical Colle
Amatya et al. BMC Dermatology (2020) 20:4 https://doi.org/10.1186/s12895-020-00100-3 RESEARCH ARTICLE Open Access Frequency of different types of facial melanoses referring to the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital in 2019, and assessment of their effect on health-related quality of life Bibush Amatya* , Anil Kumar Jha and Shristi Shrestha Abstract Background: Abnormalities of facial pigmentation, or facial melanoses, are a common presenting complaint in Nepal and are the result of a diverse range of conditions. Objectives: The objective of this study was to determine the frequency, underlying cause and impact on quality of life of facial pigmentary disorders among patients visiting the Department of Dermatology and Venereology, Nepal Medical College and Teaching Hospital (NMCTH) over the course of one year. Methods: This was a cross-sectional study conducted at the Department of Dermatology and Venereology, NMCT H. We recruited patients with facial melanoses above 16 years of age who presented to the outpatient department. Clinical and demographic data were collected and all the enrolled participants completed the validated Nepali version of the Dermatology Life Quality Index (DLQI). Results: Between January 5, 2019 to January 4, 2020, a total of 485 patients were recruited in the study. The most common diagnoses were melasma (166 patients) and post acne hyperpigmentation (71 patients). Quality of life impairment was highest in patients having melasma with steroid induced rosacea-like dermatitis (DLQI = 13.54 ± 1.30), while it was lowest in participants with ephelides (2.45 ± 1.23). Conclusion: Facial melanoses are a common presenting complaint and lead to substantial impacts on quality of life. -
Granuloma Annulare: Not As Simple As It Seems
Thomas Jefferson University Jefferson Digital Commons Department of Dermatology and Cutaneous Department of Dermatology and Cutaneous Biology Faculty Papers Biology 9-1-2010 Granuloma annulare: not as simple as it seems. Lawrence Charles Parish Thomas Jefferson University Joseph A. Witkowski University of Pennsylvania School of Medicine Follow this and additional works at: https://jdc.jefferson.edu/dcbfp Part of the Dermatology Commons Let us know how access to this document benefits ouy Recommended Citation Parish, Lawrence Charles and Witkowski, Joseph A., "Granuloma annulare: not as simple as it seems." (2010). Department of Dermatology and Cutaneous Biology Faculty Papers. Paper 76. https://jdc.jefferson.edu/dcbfp/76 This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Department of Dermatology and Cutaneous Biology Faculty Papers by an authorized administrator of the Jefferson Digital Commons. For more information, please contact: [email protected]. Granuloma Annulare: Not as simple as -
Melasma on the Nape of the Neck in a Man
Letters to the Editor 181 Melasma on the Nape of the Neck in a Man Ann A. Lonsdale-Eccles and J. A. A. Langtry Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, UK. E-mail: [email protected] Accepted July 19, 2004. Sir, sunlight and photosensitizing agents may be more We report a 47-year-old man with light brown macular relevant. pigmentation on the nape of his neck (Fig. 1). It was The differential diagnosis for pigmentation at this site asymptomatic and had developed gradually over 2 years. includes Riehl’s melanosis, Berloque dermatitis and He worked outdoors as a pipe fitter on an oilrig module; poikiloderma of Civatte. Riehl’s melanosis typically however, he denied exposure at this site because he involves the face with a brownish-grey pigmentation; always wore a shirt with a collar that covered the biopsy might be expected to show interface change and affected area. However, on further questioning it liquefaction basal cell degeneration with a moderate transpired that he spent most of the day with his head lymphohistiocytic infiltrate, melanophages and pigmen- bent forward. This reproducibly exposed the area of tary incontinence in the upper dermis. It is usually pigmentation with a sharp cut off inferiorly at the level associated with cosmetic use and may be considered of his collar. He used various shampoos, aftershaves and synonymous with pigmented allergic contact dermatitis shower gels, but none was applied directly to that area. of the face (6, 7). Berloque dermatitis is considered to be His skin was otherwise normal and there was no family caused by a photoirritant reaction to bergapentin; it history of abnormal pigmentation. -
An Unusual Presentation of a Unilateral Asymptomatic Riehl's
ts & C por a e se R S l Michael, Med Rep Case Stud 2018, 3:1 t a u c d i i DOI: 10.4172/2572-5130.1000152 d e s e M + Medical Reports and Case Studies ISSN: 2572-5130 Case Report Open Access An Unusual Presentation of a Unilateral Asymptomatic Riehl’s Melanosis in a 45 Year Old Male Chan Kam Tim Michael* Department of Dermatology, Hong Kong Academy of Medicine, Hong Kong *Corresponding author: Chan Kam Tim Michael, Department of Dermatology, Hong Kong Academy of Medicine, Hong Kong, Tel: +85221282129; E-mail: [email protected] Received Date: Feb 12, 2018; Accepted Date: Mar 12, 2018; Published Date: Mar 21, 2018 Copyright: © 2018 Michael CKT. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Introduction but of post-inflammatory hyperpigmentation, Acquired unilateral Nevus (Hori’s Nevus), Riehl’s melanosis, Drug-induced Pigmented contact dermatitis (PCD), also known as Riehl’s hyperpigmentation, Lichenoid dermatitis; as well as Melasma and melanosis, is a rare facial hyperpigmentation usually secondary to Ochronosis. cosmetics. There are few documented reports in the literature, and many cases without proven diagnosis may have been treated with pigment lasers, especially in beauty parlour settings. We report a case referred from a private practitioner who has a special interest in dermatology. The patient was diagnosed subsequently as having Riehl’s melanosis and treated with non-tyrosinase inhibitor bleaching agents, sun avoidance and mandatory abstinence from over-the-counter cosmetic products. -
Hyperpigmentation on the Head and Neck
PHOTO CHALLENGE Hyperpigmentation on the Head and Neck Blake E. Vest, MD; Spyros M. Siscos, MD; Anand Rajpara, MD A 78-year-old Asian woman presented to the dermatology clinic with progressively worsening dark spots on the forehead and neck of 3 months’ duration. She noted mild pruritis and hair loss involving the eyebrows and anterior scalp. Her medical history was notable for type 2 diabetes mellitus. She deniedcopy any new medical condi- tions or medications and had no prior history of similar symptoms. Physical examination showed hyperpigmented brown macules and patches on the forehead (top) and anterior neck (bottom) withnot sparing of the posterior neck and lower face. Alopecia with areas of perifollicular erythema and hyperpigmentation with reduced follicular open- ings were present on the eyebrows and anterior Doforehead. Two punch biopsies of head and neck lesions were performed. WHAT’S YOUR DIAGNOSIS? a. ashy dermatosis b. frontal fibrosing alopecia overlapping with lichen planus pigmentosus c. keratosis follicularis spinulosa decalvans d. postinflammatory hyperpigmentation CUTIS e. pseudopelade of Brocq PLEASE TURN TO PAGE E3 FOR THE DIAGNOSIS Dr. Vest is from Southern Illinois University School of Medicine, Springfield. Drs. Siscos and Rajpara are from the Division of Dermatology, University of Kansas School of Medicine, Kansas City. The authors report no conflict of interest. Correspondence: Blake E. Vest, MD ([email protected]). doi:10.12788/cutis.0226 E2 I CUTIS® WWW.MDEDGE.COM/DERMATOLOGY Copyright Cutis 2021. No part of this publication may be reproduced, stored, or transmitted without the prior written permission of the Publisher. PHOTO CHALLENGE DISCUSSION THE DIAGNOSIS: Frontal Fibrosing Alopecia Overlapping With Lichen Planus Pigmentosus icroscopic examination revealed focal dermal of the skin have been reported, including the entire pigmentation, papillary fibrosis, and epidermal scalp, eyebrows, and eyelashes. -
Annex 1: List of Medical Case Rates
ANNEX 1. LIST OF MEDICAL CASE RATES FIRST CASE RATE ICD CODE DESCRIPTION GROUP Professional Health Care Case Rate Fee Institution Fee P91.3 Neonatal cerebral irritability ABNORMAL SENSORIUM IN THE NEWBORN 12,000 3,600 8,400 P91.4 Neonatal cerebral depression ABNORMAL SENSORIUM IN THE NEWBORN 12,000 3,600 8,400 P91.6 Hypoxic ischemic encephalopathy of newborn ABNORMAL SENSORIUM IN THE NEWBORN 12,000 3,600 8,400 P91.8 Other specified disturbances of cerebral status of newborn ABNORMAL SENSORIUM IN THE NEWBORN 12,000 3,600 8,400 P91.9 Disturbance of cerebral status of newborn, unspecified ABNORMAL SENSORIUM IN THE NEWBORN 12,000 3,600 8,400 Peritonsillar abscess; Abscess of tonsil; Peritonsillar J36 ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 cellulitis; Quinsy Other diseases of larynx; Abscess of larynx; Cellulitis of larynx; Disease NOS of larynx; Necrosis of larynx; J38.7 ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 Pachyderma of larynx; Perichondritis of larynx; Ulcer of larynx Retropharyngeal and parapharyngeal abscess; J39.0 ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 Peripharyngeal abscess Other abscess of pharynx; Cellulitis of pharynx; J39.1 ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 Nasopharyngeal abscess Other diseases of pharynx; Cyst of pharynx or nasopharynx; J39.2 ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 Oedema of pharynx or nasopharynx J85.1 Abscess of lung with pneumonia ABSCESS OF RESPIRATORY TRACT 10,000 3,000 7,000 J85.2 Abscess of lung without pneumonia; Abscess of lung NOS ABSCESS OF RESPIRATORY -
Natural Remedies of Common Human Parasites and Pathogens
ACTA SCIENTIFIC MICROBIOLOGY (ISSN: 2581-3226) Volume 2 Issue 11 November 2019 Investigation Paper Natural Remedies of Common Human Parasites and Pathogens Omar M Amin* Parasitology Center, Scottsdale, Arizona *Corresponding Author: Omar M Amin, Parasitology Center, Scottsdale, Arizona. Received: July 12, 2019; Published: October 16, 2019 DOI: 10.31080/ASMI.2019.02.0401 • Bleeding. • Appetite changes. • Malabsorption. • Mucus. • Rectal itching. • Gut leakage. • Poor digestion. • Systemic/other symptoms • Fatigue. • Skin rash. • Dry cough. • Brain fog/memory loss. • Lymph blockage. Figure 1 • Allergies. • Nausea. Diagnosis and management of: • Muscle or joint pain. • Parasitic organisms and agents of medical and public • Dermatitis. health importance in fecal, blood, skin, urine specimens. • Headaches. • Toxicities related to Neurocutaneous Syndrome (NCS). • Insomnia. Development of anti-parasitic herbal products (F/C/R) Edu- How we get infected cational services: workshops, seminars, training and publications Drinking water or juice: Giardia, Cryptosporidium. provided. 1. 2. Skin contact with contaminated water: Schistosomi- Consultations and protocols for herbal and allopathic treat- asis, swimmers itch. ments. Research: over 220 publications on parasites from all con- Food (fecal-oral infections): most protozoans, ex., tinents. 3. Blastocysts, Entamoeba spp. and worms: Ascaris. Why test? 4. Arthropods: Lyme disease, plague, typhus, etc. You need to be tested if you have one or more of these symp- 5. Air: Upper respiratory tract infections (viruses, bac- toms: teria), ex GI symptoms 6. Pets: Hydatid., flu, Valleycyst disease,fever, Hanta heart virus. worm, larva mi- grans (dogs), Toxoplasma (cats), Taenia (beef, swine. • Diarrhea/constipation. People (contagious diseases): AIDS, herpes. • Irritable bowel 7. Soil: hook worms, thread worms. • Cramps 8. -
Cutaneous Balamuthia Mandrillaris Infection As a Precursor To
Volume 23 Number 7 | July 2017 Dermatology Online Journal || Case Report DOJ 23 (7): 4 Cutaneous Balamuthia mandrillaris infection as a precursor to Balamuthia amoebic encephalitis (BAE) in a healthy 84-year-old Californian Larisa M Lehmer, Gabriel E Ulibarri, Bruce D Ragsdale, James Kunkle Affiliations: University of California Irvine Health, Department of Dermatology, Irvine, California, Central Coast Pathology Laboratory, San Luis Obispo, California, Western Diagnostic Services Laboratory, San Luis Obispo, California, Central Coast Dermatology, Arroyo Grande, California Corresponding Author: Larisa M Lehmer, Department of Dermatology, UC Irvine Health, 118 Med Surg 1, Irvine, CA 92697-2400, Email: [email protected] Abstract Keywords: Balamuthia mandrillaris; cutaneous balamuthiasis; granulomatous amoebic encephalitis; Soil and freshwater-dwelling amoebae may GAE; balamuthia amoebic encephalitis; BAE; opportunistically infect the skin and evoke a immunocompromise; granulomatous dermatitis; granulomatous dermatitis that camouflages their immune senescence. underlying morphology. Amoebic infestations are incredibly rare in the U.S., predominantly occurring in the young, elderly, and immunocompromised. Introduction Sadly, because diagnosis is difficult and unsuspected, Balamuthia mandrillaris (B. mandrillaris), along most cases are diagnosed at autopsy. The following with Naegleria, Sappinia and several species of case is of a healthy 84-year-old man with a non- Acanthomeba, are free-living amoebae found in fresh healing nodulo-ulcerative cutaneous lesion on his water and soil worldwide that may opportunistically left forearm that appeared following a gardening infect the skin and/or central nervous system (CNS) injury. Lesional punch biopsies repeatedly showed of humans. The first sign of infection ranges from non-specific granulomatous inflammation with a stubborn indurated plaque or ulceration on the no pathogens evident histologically or by culture. -
Die Prinzipien Der Chirurgischen Therapie Beim Fortgeschrittenen
Aus der Chirurgischen Klinik und Poliklinik - Innenstadt, der Ludwig-Maximilian- Universität-München Direktor: Prof. Dr. med. Wolf Mutschler Die Prinzipien der chirurgischen Therapie beim fortgeschrittenen Pyoderma gangränosum Dissertation zum Erwerb des Doktorgrades der Medizin an der Medizinischen Fakultät der Ludwig-Maximilians-Universität zu München vorgelegt von Christoph Hendrik Volkering aus Groß-Gerau 2008 Mit Genehmigung der Medizinischen Fakultät der Universität München Berichterstatter: Prof. Dr. Sigurd Keßler Mitberichterstatter: Prof. Dr. Hans C. Korting Priv. Doz. Dr. Martin K. Angele Dekan: Prof. Dr. med. Dr. h.c. Maximilian Reiser, FACR Tag der mündlichen Prüfung: 20.11.2008 - 2 - INHALT 1. Einleitung: ........................................................................................................... - 6 - 1.1. Das Pyoderma gangränosum: ..................................................................... - 6 - 1.1.1. Geschichte: ......................................................................................... - 6 - 1.1.2. Inzidenz: ............................................................................................. - 6 - 1.1.3. Assoziierte Erkrankungen: .................................................................. - 7 - 1.1.4. Typen des Pyoderma gangränosum: .................................................. - 9 - 1.1.5. Histopathologie: ................................................................................ - 12 - 1.1.6. Pathogenese: ................................................................................... -
Table I. Genodermatoses with Known Gene Defects 92 Pulkkinen
92 Pulkkinen, Ringpfeil, and Uitto JAM ACAD DERMATOL JULY 2002 Table I. Genodermatoses with known gene defects Reference Disease Mutated gene* Affected protein/function No.† Epidermal fragility disorders DEB COL7A1 Type VII collagen 6 Junctional EB LAMA3, LAMB3, ␣3, 3, and ␥2 chains of laminin 5, 6 LAMC2, COL17A1 type XVII collagen EB with pyloric atresia ITGA6, ITGB4 ␣64 Integrin 6 EB with muscular dystrophy PLEC1 Plectin 6 EB simplex KRT5, KRT14 Keratins 5 and 14 46 Ectodermal dysplasia with skin fragility PKP1 Plakophilin 1 47 Hailey-Hailey disease ATP2C1 ATP-dependent calcium transporter 13 Keratinization disorders Epidermolytic hyperkeratosis KRT1, KRT10 Keratins 1 and 10 46 Ichthyosis hystrix KRT1 Keratin 1 48 Epidermolytic PPK KRT9 Keratin 9 46 Nonepidermolytic PPK KRT1, KRT16 Keratins 1 and 16 46 Ichthyosis bullosa of Siemens KRT2e Keratin 2e 46 Pachyonychia congenita, types 1 and 2 KRT6a, KRT6b, KRT16, Keratins 6a, 6b, 16, and 17 46 KRT17 White sponge naevus KRT4, KRT13 Keratins 4 and 13 46 X-linked recessive ichthyosis STS Steroid sulfatase 49 Lamellar ichthyosis TGM1 Transglutaminase 1 50 Mutilating keratoderma with ichthyosis LOR Loricrin 10 Vohwinkel’s syndrome GJB2 Connexin 26 12 PPK with deafness GJB2 Connexin 26 12 Erythrokeratodermia variabilis GJB3, GJB4 Connexins 31 and 30.3 12 Darier disease ATP2A2 ATP-dependent calcium 14 transporter Striate PPK DSP, DSG1 Desmoplakin, desmoglein 1 51, 52 Conradi-Hu¨nermann-Happle syndrome EBP Delta 8-delta 7 sterol isomerase 53 (emopamil binding protein) Mal de Meleda ARS SLURP-1