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JUN-AN CHEN, Ph.D. Jachen@Imb.Sinica.Edu.Tw Mar 2016 JUN-AN CHEN, Ph.D. [email protected] Institute of Molecular Biology Academia Sinica, Taipei, Taiwan, 11529 Tel: +886-2-2788-0460 Fax: +886-2-2782-6085 http://www.imb.sinica.edu.tw/~jachen/ EDUCATION University of Cambridge 2002-2006 PhD, The Wellcome Trust Cancer Research UK Gurdon Institute, UK. National Taiwan University (NTU) 1997-1999 MSc, Institute of Biochemical Sciences, Taiwan. National Chung Cheng University (NCCU) 1993-1997 BSc, Department of Chemistry, Taiwan. CAREER/ACADEMIC POSITIONS Assistant Research Fellow: 2012-present Principal Investigator, Institute of Molecular Biology, Academia Sinica, Taiwan. Postdoctoral Fellow: 2007-2012 Supervised by Dr. Hynek Wichterle, Columbia University, USA. PhD student: 2002-2006 Supervised by Dr. Enrique Amaya, The Wellcome Trust/CR UK Gurdon Institute, University of Cambridge, UK. Teaching Instructor: 2001-2002 Institute of Biochemical Sciences, National Taiwan University, Taiwan. PROFESSIONAL HONORS & RECOGNITION Taiwan National Science Council Talented Investigator Fellowship 2012-2015 Taiwan National Science Council Postdoctoral Fellowship 2008-2009 The Wellcome Trust Scholarship 2002-2006 Taiwan International PhD Scholarship 2002-2005 Presidential Award in NCCU 2000 1 Mar 2016 SCIENTIFIC MEETING ORGANIZER Avian Model System 9: A new Integrative Platform, Taipei, Academia Sinica 2016 INVITED CONFERENCE TALKS CiRA/ ISSCR 2016 International Symposia- Pluripotency: From Basic Science to 2016 200 Therapeutic Applications International Symposium 4 EMBO Neural Development, Taipei, Taiwan. 2015 International Conference on Stem Cells and Developmental Biology , Taipei, 2015 Taiwan. Annual Biochemistry and Molecular Biology Conference, Tainan, Taiwan. 2015 Academia Sinica Symposium on RNA Biology, Taiwan. 2015 Asia-Pacific Developmental Biology Conference, Xi-An, China. 2015 International Conference on the Long and the Short of Non-Coding RNAs, Crete, 2015 Greece. Annual Chinese Society for Cell Biology Conference, Shenzen, China. 2015 Academia Sinica Minisymposium on RNA Biology, Taiwan. 2014 Annual Symposium on Brain and Mind Sciences, Taiwan. 2014 Indo-Taiwan Joint Interdisciplinary Neuroscience Symposium 2014 Hyderabad, India. Young Investigator Lecture 2013 Annual Biochemistry and Molecular Biology Conference, Taichung, Taiwan. Annual neuroscience meeting, Taipei, Taiwan. 2013 Computational Modeling of Regenerative Medicine and Cellular Pattern 2013 Formation, IEEE Biomedical Meeting, Osaka, Japan. The 28th Joint Annual Conference of Biomedical Science, Taipei, Taiwan. 2012 Cold Spring Harbor Asia Conferences in Stem Cells and Developmental 2012 Mechanisms, Suzhou, China. th International Symposium on Recent Advances in Stem Cells and Cancer & the 8 2012 Annual Meeting of TSSCR, Kaohsiung, Taiwan. Asia-Pacific Developmental Biology Conference, Taipei, Taiwan. 2012 First International Non-coding & MicroRNAs-2009 West Coast Summit, San 2009 Francisco, USA. 2 Mar 2016 International Symposium on Recent Advances in Stem Cell Research Annual 2006 Meeting of Taiwan Society for Stem Cell Research, Taipei, Taiwan. British Cell Biology/Developmental Biology Society joined Annual Meeting 2005 Warwick, UK. Selected presentation for “Young Geneticist of the Year” British Genetics Society, 2004 Warwick, UK. TEACHING EXPERIENCE TIGP Career Education Series lecture organizer (annual) 2016~present TIGP INS student seminar lecture organizer (Fall) 2014~present YM PhD student seminar lecture organizer (Fall) 2013 TIGP neuroscience/developmental biology - Neural induction and polarity (Fall) 2013-present TIGP neuroscience – Spinal cord movement and control (Fall) 2013-present Translational medicine – Stem cells and neural development and degeneration 2013-present (Fall) National defense PhD program – Motor neuron disease (Spring) 2013-present TIGP-MCB – RNA Biology (Spring, biannual) 2013-present TIGP-MCB – Epigenetic Regulation and RNAi mechanism (Fall) 2014-present INVITED FORMAL PRESENTATIONS Chinese Academia of Science Shanghai 2016 Shanghai Chao Tung University 2016 City University of Hong Kong 2016 Chang Gung University 2015 Taipei Medical University 2015 National Chio Tung University, Taiwan 2014 National Health Research Institute, Taiwan 2013 National Taiwan University, Taiwan 2013 National Yang Ming University, Taiwan 2012 SERVICE AND LEADERSHIP Editorial board: Frontiers in Genetics (non-coding RNA) 2014-present Solicited Journal Reviewer Service: Cell Reports, Development, Developmental 2012-present Biology, EMBO, Nature Communication, Mechanism of Development, PLOS one, Journal of Biomedical Science, Scientific Reports, Stem Cells. Solicited Grant Reviewer Service: UK MRC, Taiwan NSC/MoST 2012-present Academia Sinica Animal Protocol Committee 2012-present Pan Science Consulting Board: http://pansci.tw 2013~present 3 Mar 2016 Sciscape Editorial Board: http://www.sciscape.org/ 2002-2010 Lieutenant: Mandatory Military Service in Coast Guard Administration 1999-2001 GRANT HISTORY WITHIN 3 YEARS Agency: NSC I.D.# 101-2314-B-001 -004 -MY3 Title: “Decipher the role of microRNA in the establishment of motor neuron rostrocaudal identity” P.I.: Jun-An Chen Project period 12/1/2012-7/31/2015 Agency: NSC I.D.# 102-2321-B-001 -057 - Title: “Identification and characterization of specific microRNA in maintaining motor neuron survival” P.I.: Jun-An Chen Project period 8/1/2013-7/31/2015 Agency: RPAS Academia Sinica I.D.# AS 022323 Title: “Characterization of non coding RNA in Motor Neuron Disease” P.I.: Jun-An Chen Project period 1/1/2013-12/31/2013 Agency: Thematic PPG Academia Sinica I.D.# AS 022323 Title: “Neurogenesis mechanism” P.I.: Tang Tang/Jun-An Chen and others Project period 1/1/2015-12/31/2017 Agency: NHRI I.D.# NHRI-EX103-10315NC Title: “The role of non-coding RNA during motor neuron degeneration in spinal muscular atrophy” P.I.: Jun-An Chen Project period 1/1/2014-12/31/2017 Agency: MoST I.D.# 104-2311-B-001 -030 -MY3 Title: “Direct ESCs into motor neuron subtypes and dissect the molecular mechanism underlying motor neuron subtype diversification” P.I.: Jun-An Chen Project period 8/1/2015-7/31/2018 PEER-REVIEWED PUBLICATIONS Correspondence in IMB Academia Sinica Li CJ, Hong T, Tung YT, Yen YP, Ho HC, Lu YL, Chang M, Nie Q*, Chen JA*. (2015) MicroRNA Filters Hox Transcription Noise and Confers Robust Boundary Formation in the Spinal Cord. Nature Comm (in revision). Tung YT, Lu YL, Peng KC, Yen YP, Chang M, Li J, Jung H, Thams S, Huang YP, Hung JH, Chen JA*. (2015) Mir-17∼92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN. Cell Rep. 2015 May 20. 4 Mar 2016 10.1016/j.celrep.2015.04.050. (Cover featured article). This article is highlighted by Science Signaling Editors Choice, Alzforum.org , The ALS Forum. and PanScience (泛科學). Anderegg A, Lin H-P, Chen J-A, Caronia-Brown G, Cherepanova N, et al. (2013) An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool. PLoS Genet 9(12): e1003973. doi:10.1371/journal.pgen.1003973. Chen J-A* and Wichterle H*. (2012). Apoptosis of Limb Innervating Motor Neurons and Erosion of Motor Pool Identity upon Lineage Specific Dicer Inactivation, Front. Neurosci. 6:69. doi: 10.3389/fnins.2012.00069. (Featured article). ………………………………………………………………………………………………………………. Before Academia Sinica Chen J-A, Huang Y-P, Mazzoni EO, Zavadil J, Tan GC, and Wichterle H. (2011) Mir-17-3p Controls Spinal Neural Progenitor Patterning by Regulating Olig2/Irx3 Cross-Repressive Loop, Neuron, 69(4). 721-35 (Featured article). This article is recommended by F1000 Bushati N, Briscoe J: 2011. F1000.com/8756957. Chen J-A, Chu S-T, and Amaya E. (2007) Maintenance of Motor Neuron Progenitors in Xenopus Requires a Novel Localized Cyclin. EMBO Reports 8:287-292 (Featured article). Chen J-A, Voigt J, Gilchrist M, Papalopulu N and Amaya E. (2005) Identification of novel genes affecting mesoderm formation and morphogenesis through an enhanced large scale functional screen in Xenopus. Mechanisms of Development 122:307-331 (Featured article to make cover poster). Voigt J, Chen J-A, Gilchrist M, Amaya E and Papalopulu N. (2005) Expression cloning screening of a unique and full-length set of cDNA clones is an efficient method for identifying genes involved in Xenopus neurogenesis. Mechanisms of Development 122:289-306. REFERENCES Hynek Wichterle, Ph.D. Enrique Amaya, Ph.D. Associate Professor and Professor of the Healing Foundation Co-director of Project ALS Michael Smith Building Department of Pathology and Cell Biology University of Manchester Columbia University Oxford Road P&S 14-401G, 630W, 168th St Manchester M13 9PT New York, NY, 10032 United Kingdom Tel:+1- 212-342-3929 Tel: +44 (0)161 275 5360 mailto:[email protected] [email protected] Fiona Doetsch, Ph.D. Nancy Papalopulu, Ph.D. Professor EMBO member Biozentrum Professor of Developmental Neuroscience 5 Mar 2016 University of Basel Michael Smith Building Klingelbergstrasse 50 / 70 University of Manchester CH - 4056 Basel Oxford Road Biozentrum, Room 708 Manchester M13 9PT Phone: +41 61 267 22 30 Tel: +44 (0)161 306 8907 Email: fiona.doetsch-at-unibas.ch [email protected] 6 .
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