COMENIUS UNIVERSITY in BRATISLAVA Faculty of Natural Sciences
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Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam
viruses Article Molecular Phylogeny of Mobatviruses (Hantaviridae) in Myanmar and Vietnam Satoru Arai 1, Fuka Kikuchi 1,2, Saw Bawm 3 , Nguyễn Trường Sơn 4,5, Kyaw San Lin 6, Vương Tân Tú 4,5, Keita Aoki 1,7, Kimiyuki Tsuchiya 8, Keiko Tanaka-Taya 1, Shigeru Morikawa 9, Kazunori Oishi 1 and Richard Yanagihara 10,* 1 Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; [email protected] (S.A.); [email protected] (F.K.); [email protected] (K.A.); [email protected] (K.T.-T.); [email protected] (K.O.) 2 Department of Chemistry, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan 3 Department of Pharmacology and Parasitology, University of Veterinary Science, Yezin, Nay Pyi Taw 15013, Myanmar; [email protected] 4 Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, Hanoi, Vietnam; [email protected] (N.T.S.); [email protected] (V.T.T.) 5 Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam 6 Department of Aquaculture and Aquatic Disease, University of Veterinary Science, Yezin, Nay Pyi Taw 15013, Myanmar; [email protected] 7 Department of Liberal Arts, Faculty of Science, Tokyo University of Science, Tokyo 162-8601, Japan 8 Laboratory of Bioresources, Applied Biology Co., Ltd., Tokyo 107-0062, Japan; [email protected] 9 Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; [email protected] 10 Pacific Center for Emerging Infectious Diseases Research, John A. -
Clinically Important Vector-Borne Diseases of Europe
Natalie Cleton, DVM Erasmus MC, Rotterdam Department of Viroscience [email protected] No potential conflicts of interest to disclose © by author ESCMID Online Lecture Library Erasmus Medical Centre Department of Viroscience Laboratory Diagnosis of Arboviruses © by author Natalie Cleton ESCMID Online LectureMarion Library Koopmans Chantal Reusken [email protected] Distribution Arboviruses with public health impact have a global and ever changing distribution © by author ESCMID Online Lecture Library Notifications of vector-borne diseases in the last 6 months on Healthmap.org Syndromes of arboviral diseases 1) Febrile syndrome: – Fever & Malaise – Headache & retro-orbital pain – Myalgia 2) Neurological syndrome: – Meningitis, encephalitis & myelitis – Convulsions & coma – Paralysis 3) Hemorrhagic syndrome: – Low platelet count, liver enlargement – Petechiae © by author – Spontaneous or persistent bleeding – Shock 4) Arthralgia,ESCMID Arthritis and Online Rash: Lecture Library – Exanthema or maculopapular rash – Polyarthralgia & polyarthritis Human arboviruses: 4 main virus families Family Genus Species examples Flaviviridae flavivirus Dengue 1-5 (DENV) West Nile virus (WNV) Yellow fever virus (YFV) Zika virus (ZIKV) Tick-borne encephalitis virus (TBEV) Togaviridae alphavirus Chikungunya virus (CHIKV) O’Nyong Nyong virus (ONNV) Mayaro virus (MAYV) Sindbis virus (SINV) Ross River virus (RRV) Barmah forest virus (BFV) Bunyaviridae nairo-, phlebo-©, orthobunyavirus by authorCrimean -Congo heamoragic fever (CCHFV) Sandfly fever virus -
Immunogenicity and Serological Applications of Flavivirus Ed Iii Proteins and Multiplex Rt-Pcr for Detecting Novel Southern African Viruses
IMMUNOGENICITY AND SEROLOGICAL APPLICATIONS OF FLAVIVIRUS ED III PROTEINS AND MULTIPLEX RT-PCR FOR DETECTING NOVEL SOUTHERN AFRICAN VIRUSES Lehlohonolo Mathengtheng Thesis submitted in fulfillment of the requirements for the degree Ph.D Virology in the Department of Medical Microbiology and Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein Promotor: Prof Felicity Burt, Department of Medical Microbiology and Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein January 2015 Table of contents Table of contents ................................................................................................................................................. 2 Declaration ............................................................................................................................................................ i Acknowledgements .............................................................................................................................................. ii Financial Support ................................................................................................................................................ iii Lehlohonolo Mathengtheng, An Obituary ........................................................................................................... v Publications and presentations........................................................................................................................... vii List of figures ....................................................................................................................................................... -
Zoonotické Viry U Volně Žijících Endotermních Obratlovců
MASARYKOVA UNIVERZITA PŘÍRODOVĚDECKÁ FAKULTA Ústav experimentální biologie Oddělení mikrobiologie a molekulární biotechnologie Zoonotické viry u volně žijících endotermních obratlovců Dizertační práce Brno 2017 Petra Straková MASARYKOVA UNIVERZITA PŘÍRODOVĚDECKÁ FAKULTA Ústav experimentální biologie Oddělení mikrobiologie a molekulární biotechnologie Zoonotické viry u volně žijících endotermních obratlovců Dizertační práce Petra Straková Školitel: prof. RNDr. Zdeněk Hubálek, DrSc. Brno 2017 Bibliografický záznam Autor: Mgr. Petra Straková Ústav biologie obratlovců AV ČR v.v.i., Brno - detašované pracoviště Valtice a Ústav experimentální biologie, PřF MU, Brno Název práce: Zoonotické viry u volně žijících endotermních obratlovců Studijní program: Biologie Studijní obor: Mikrobiologie Školitel: prof. RNDr. Zdeněk Hubálek, DrSc. Ústav biologie obratlovců AV ČR v.v.i., Brno - detašované pracoviště Valtice a Ústav experimentální biologie, PřF MU, Brno Valtice Akademický rok: 2016/2017 Počet stran: 155 + publikace Klíčová slova: emergentní zoonózy, hantaviry, flaviviry, virus západonilské horečky, virus Usutu, virus hepatitidy E, Česká republika, Evropa Bibliographic entry Author: Mgr. Petra Straková Institute of Vertebrate Biology of the Czech Academy of Sciences, Brno – laboratory Valtice, and Department of Experimental Biology, Faculty of Science, Masaryk University, Brno Title of Dissertation: Zoonotic viruses associated with free-living endotherm vertebrates Degree Programme: Biology Field of Study: Microbiology Supervisor: prof. RNDr. -
Hantavirus Infection: a Global Zoonotic Challenge
VIROLOGICA SINICA DOI: 10.1007/s12250-016-3899-x REVIEW Hantavirus infection: a global zoonotic challenge Hong Jiang1#, Xuyang Zheng1#, Limei Wang2, Hong Du1, Pingzhong Wang1*, Xuefan Bai1* 1. Center for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi’an 710032, China 2. Department of Microbiology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China Hantaviruses are comprised of tri-segmented negative sense single-stranded RNA, and are members of the Bunyaviridae family. Hantaviruses are distributed worldwide and are important zoonotic pathogens that can have severe adverse effects in humans. They are naturally maintained in specific reservoir hosts without inducing symptomatic infection. In humans, however, hantaviruses often cause two acute febrile diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS). In this paper, we review the epidemiology and epizootiology of hantavirus infections worldwide. KEYWORDS hantavirus; Bunyaviridae, zoonosis; hemorrhagic fever with renal syndrome; hantavirus cardiopulmonary syndrome INTRODUCTION syndrome (HFRS) and HCPS (Wang et al., 2012). Ac- cording to the latest data, it is estimated that more than Hantaviruses are members of the Bunyaviridae family 20,000 cases of hantavirus disease occur every year that are distributed worldwide. Hantaviruses are main- globally, with the majority occurring in Asia. Neverthe- tained in the environment via persistent infection in their less, the number of cases in the Americas and Europe is hosts. Humans can become infected with hantaviruses steadily increasing. In addition to the pathogenic hanta- through the inhalation of aerosols contaminated with the viruses, several other members of the genus have not virus concealed in the excreta, saliva, and urine of infec- been associated with human illness. -
Omsk Hemorrhagic Fever (OHF)
Omsk Hemorrhagic Fever (OHF) Omsk hemorrhagic fever (OHF) is caused by Omsk hemorrhagic fever virus (OHFV), a member of the virus family Flaviviridae. OHF was described between 1945 and 1947 in Omsk, Russia from patients with hemorrhagic fever. Rodents serve as the primary host for OHFV, which is transmitted to rodents from the bite of an infected tick. Common tick vectors include Dermacentor reticulatus, Dermacentor marginatus, Ixodes persulcatus and common rodents infected with OHFV include the muskrat (Ondatra zibethica), water vole (Arvicola terrestris), and narrow-skulled voles (Microtus gregalis). Muskrats are not native to the Omsk region but were introduced to the area and are now a common target for hunters and trappers. Like humans, muskrats fall ill and die when infected with the virus. OHF occurs in the western Siberia regions of Omsk, Novosibirsk, Kurgan and Tyumen. Transmission Humans can become infected through tick bites or through contact with the blood, feces, or urine of an infected, sick, or dead animal – most commonly, rodents. Occupational and recreational activities such as hunting or trapping may increase human risk of infection. Transmission may also occur with no direct tick or rodent exposure as OHFV appears to be extremely stable in different environments. It has been isolated from aquatic animals and water and there is even evidence that OHFV can be transmitted through the milk of infected goats or sheep to humans. No human to human transmission of OHFV has been documented but infections due to lab contamination have been described. Signs and Symptoms After an incubation period of 3-8 days, the symptoms of OHF begin suddenly with chills, fever, headache, and severe muscle pain with vomiting, gastrointestinal symptoms and bleeding problems occurring 3-4 days after initial symptom onset. -
Zoonotic Potential of International Trade in CITES-Listed Species Annexes B, C and D JNCC Report No
Zoonotic potential of international trade in CITES-listed species Annexes B, C and D JNCC Report No. 678 Zoonotic potential of international trade in CITES-listed species Annex B: Taxonomic orders and associated zoonotic diseases Annex C: CITES-listed species and directly associated zoonotic diseases Annex D: Full trade summaries by taxonomic family UNEP-WCMC & JNCC May 2021 © JNCC, Peterborough 2021 Zoonotic potential of international trade in CITES-listed species Prepared for JNCC Published May 2021 Copyright JNCC, Peterborough 2021 Citation UNEP-WCMC and JNCC, 2021. Zoonotic potential of international trade in CITES- listed species. JNCC Report No. 678, JNCC, Peterborough, ISSN 0963-8091. Contributing authors Stafford, C., Pavitt, A., Vitale, J., Blömer, N., McLardy, C., Phillips, K., Scholz, L., Littlewood, A.H.L, Fleming, L.V. & Malsch, K. Acknowledgements We are grateful for the constructive comments and input from Jules McAlpine (JNCC), Becky Austin (JNCC), Neville Ash (UNEP-WCMC) and Doreen Robinson (UNEP). We also thank colleagues from OIE for their expert input and review in relation to the zoonotic disease dataset. Cover Photographs Adobe Stock images ISSN 0963-8091 JNCC Report No. 678: Zoonotic potential of international trade in CITES-listed species Annex B: Taxonomic orders and associated zoonotic diseases Annex B: Taxonomic orders and associated zoonotic diseases Table B1: Taxonomic orders1 associated with at least one zoonotic disease according to the source papers, ranked by number of associated zoonotic diseases identified. -
Aus Dem Institut Für Medizinische Virologie Der Medizinischen Fakultät Charité – Universitätsmedizin Berlin
Aus dem Institut für medizinische Virologie der Medizinischen Fakultät Charité – Universitätsmedizin Berlin DISSERTATION Genetic reassortment between members of different Dobrava-Belgrade virus lineages and allocation of innate immune response modulation to particular genome segments zur Erlangung des akademischen Grades Doctor rerum medicarum (Dr. rer. medic.) vorgelegt der Medizinischen Fakultät Charité – Universitätsmedizin Berlin von Sina Kirsanovs aus Bremen Gutachter/in: 1. Prof. Dr. med. D. H. Krüger 2. Prof. Dr. med. H.-W. Presber 3. Priv.-Doz. Dr. R. Ulrich Datum der Promotion: 03.09.2010 Abstract Hantaviruses possess a tri-segmented negative-stranded RNA genome with the potency of genetic reassortment. Reassortment processes between genome segments might cause dramatic changes in the virulence of viruses as has been shown for influenza viruses. The European Dobrava-Belgrade virus species (DOBV) forms distinct lineages associated with different Apodemus mice species and can cause hemorrhagic fever with renal syndrome of different clinical severities. In this study, virological and molecular tools to monitor RNA reassortment in cell culture between two genetic lineages of DOBV were established. Representatives of the DOBV-Af (associated with A. flavicollis) and DOBV-Aa (associated with A. agrarius) lineages were used for dual infection of Vero E6 cells. Two hundred and seven individual virus clones were isolated and screened for reassortment by a newly established strain- and segment-specific multiplex PCR (MP-PCR). After co-infection, as much as 31% of virus progeny population was represented by genetically stable reassortants. Reassortment was proven by sequence analyses of the complete S and M segments as well as L-ORF. Two stable reassortment patterns where identified. -
Crimean-Congo Hemorrhagic Fever: History, Epidemiology, Pathogenesis, Clinical Syndrome and Genetic Diversity Dennis A
University of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln USGS Staff -- ubP lished Research US Geological Survey 2013 Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity Dennis A. Bente University of Texas Medical Branch, [email protected] Naomi L. Forrester University of Texas Medical Branch Douglas M. Watts University of Texas at El Paso Alexander J. McAuley University of Texas Medical Branch Chris A. Whitehouse US Geological Survey See next page for additional authors Follow this and additional works at: http://digitalcommons.unl.edu/usgsstaffpub Bente, Dennis A.; Forrester, Naomi L.; Watts, ouD glas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "Crimean- Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013). USGS Staff -- Published Research. 761. http://digitalcommons.unl.edu/usgsstaffpub/761 This Article is brought to you for free and open access by the US Geological Survey at DigitalCommons@University of Nebraska - Lincoln. It has been accepted for inclusion in USGS Staff -- ubP lished Research by an authorized administrator of DigitalCommons@University of Nebraska - Lincoln. Authors Dennis A. Bente, Naomi L. Forrester, Douglas M. Watts, Alexander J. McAuley, Chris A. Whitehouse, and Mike Bray This article is available at DigitalCommons@University of Nebraska - Lincoln: http://digitalcommons.unl.edu/usgsstaffpub/761 Antiviral Research 100 (2013) 159–189 Contents lists available at ScienceDirect Antiviral Research journal homepage: www.elsevier.com/locate/antiviral Review Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity ⇑ Dennis A. Bente a, , Naomi L. Forrester b, Douglas M. Watts c, Alexander J. McAuley a, Chris A. -
Zoonotic Viral Hemorrhagic Fevers (VHF) Summary Guidance for Veterinarians January 2016
Zoonotic Viral Hemorrhagic Fevers (VHF) Summary Guidance for Veterinarians January 2016 Agent 4 groups of viruses can be transmitted by animals and cause hemorrhagic fever in humans : 1. Arenaviruses: Lassa, Junin, Machupo, Guanarito, Sabia, Chapare, Lujo 2. Bunyaviruses: Hantaviruses, Nairovirus (Crimean-Congo hemorrhagic fever), Rift Valley Fever virus • Hantaviruses incl Haantan, Puumala, Dobrava, Seoul, Saaremaa (hantaviruses in the Americas (eg Sin Nombre) do not cause VHF) 3. Filoviruses: Marburg, Ebola 4. Flaviviruses: Yellow fever, Kyasanur forest disease virus, Omsk hemorrhagic fever Susceptible Affected (symptomatic) animal species species • Primates: Ebola and Marburg, Yellow fever; Ruminants : Rift Valley Fever Reservoir (asymptomatic) species • Bats (still subject of research): Ebola and Marburg • Rodents : Arenaviruses, Hantaviruses, Kyasanur forest disease virus, Omsk hemorrhagic fever virus Occurrence in None of these viruses are endemic to Canada. The importation of bats, primates and rodents, the return of human travelers from outbreak BC and the zones, as well as inadvertent importation of vectors from endemic areas present a very small risk of introduction of these viruses into BC. world Transmission • Ebola and Marburg: via direct contact with blood and other secretions and possibly droplet spread (Marburg only) • Arenaviruses and Hantaviruses: vertical transmission in rodents (Arenaviruses), aerosols or direct contact with mucosa or open wounds • Vector: • Mosquito: Yellow fever, Rift Valley Fever • Ticks: Crimean-Congo -
Pdf/Res-Rech/Mfhpb16-Eng.Pdf 8
Peer-Reviewed Journal Tracking and Analyzing Disease Trends pages 1–200 EDITOR-IN-CHIEF D. Peter Drotman Managing Senior Editor EDITORIAL BOARD Polyxeni Potter, Atlanta, Georgia, USA Dennis Alexander, Addlestone Surrey, United Kingdom Senior Associate Editor Timothy Barrett, Atlanta, GA, USA Brian W.J. Mahy, Bury St. Edmunds, Suffolk, UK Barry J. Beaty, Ft. Collins, Colorado, USA Martin J. Blaser, New York, New York, USA Associate Editors Sharon Bloom, Atlanta, GA, USA Paul Arguin, Atlanta, Georgia, USA Christopher Braden, Atlanta, GA, USA Charles Ben Beard, Ft. Collins, Colorado, USA Mary Brandt, Atlanta, Georgia, USA Ermias Belay, Atlanta, GA, USA Arturo Casadevall, New York, New York, USA David Bell, Atlanta, Georgia, USA Kenneth C. Castro, Atlanta, Georgia, USA Corrie Brown, Athens, Georgia, USA Louisa Chapman, Atlanta, GA, USA Charles H. Calisher, Ft. Collins, Colorado, USA Thomas Cleary, Houston, Texas, USA Michel Drancourt, Marseille, France Vincent Deubel, Shanghai, China Paul V. Effl er, Perth, Australia Ed Eitzen, Washington, DC, USA David Freedman, Birmingham, AL, USA Daniel Feikin, Baltimore, MD, USA Peter Gerner-Smidt, Atlanta, GA, USA Anthony Fiore, Atlanta, Georgia, USA Stephen Hadler, Atlanta, GA, USA Kathleen Gensheimer, Cambridge, MA, USA Nina Marano, Atlanta, Georgia, USA Duane J. Gubler, Singapore Martin I. Meltzer, Atlanta, Georgia, USA Richard L. Guerrant, Charlottesville, Virginia, USA David Morens, Bethesda, Maryland, USA Scott Halstead, Arlington, Virginia, USA J. Glenn Morris, Gainesville, Florida, USA David L. Heymann, London, UK Patrice Nordmann, Paris, France Charles King, Cleveland, Ohio, USA Tanja Popovic, Atlanta, Georgia, USA Keith Klugman, Atlanta, Georgia, USA Didier Raoult, Marseille, France Takeshi Kurata, Tokyo, Japan Pierre Rollin, Atlanta, Georgia, USA S.K. -
Viral Hemorrhagic Fever Surveillance Protocol
Viral Hemorrhagic Fever Surveillance Protocol Viral hemorrhagic fever (VHF) is a clinical illness associated with fever and bleeding diathesis caused by viruses belonging to 4 distinct families: Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae (Table 1). The mode of transmission, clinical course, and mortality of these illnesses vary with the specific virus, but each is capable of causing a VHF syndrome. This protocol is written in the context of the current West African Ebola outbreak of 2014. Prevention and control measures are expected to evolve as more information is gained and will vary depending on the type of VHF. Providers and public health professionals should assure that they are working from the most current guidance. Provider Responsibilities 1. Remain alert for imported cases of viral hemorrhagic fever (VHF). At this writing, returned travelers from Guinea, Liberia, and Sierra Leone are at highest risk for Ebola virus disease (formerly Ebola hemorrhagic fever); however the epidemiology of VHF can change rapidly. Consult www.cdc.gov or http://www.who.int/topics/haemorrhagic_fevers_viral/en/ for information on current outbreaks worldwide. Consider the diagnosis of VHF in returned travelers with illness including: a. Fever, b. Myalgia, c. Severe headache, d. Abdominal pain, e. Vomiting, f. Diarrhea, or g. Unexplained bleeding or bruising. 2. Other risk groups include direct contact with a confirmed or highly suspected VHF (Ebola) case. If there are no risk factors (i.e., no travel history AND no direct contact), then alternative diagnoses should be pursued. 3. For any suspected case of VHF: a. Immediately place the suspected case in isolation: At a minimum, private room, standard, droplet and contact precautions (gown, gloves, mask, goggles and hand hygiene before donning and after doffing personal protective equipment (PPE)) should be used.