a Dorsal b Dorsal c Dorsal
* * * * * * * Medial * Lateral Medial * * Lateral Medial Lateral
Ventral Ventral Ventral
d CA2 e f Fimbria CA3 CA2 CA3 Uncus Fimbria CA4 Fimbria CA1 Uncus CA4 CA1 Uncus CA3/2 DG DG DG/CA4 CA1 Pre/ parasubiculum Prosubiculum/ Prosubiculum/ subiculum Pre/parasubiculum Pre/parasubiculum Prosubiculum/ subiculum subiculum
Subregions Important Landmarks DG/CA4 CA3/2 Vestigial Hippocampal Sulcus (VHS) Uncus CA1 Fimbria / Dorsal Wall of the Hippocampus Prosubiculum/subiculum * - Islands Indicating Presubiculum Pre/parasubiculum Uncus Figure 1 Figure 2 Dorsal a b c d e f Posterior
Medial Lateral
DG/CA4 CA1 Pre/parasub
Anterior CA3/2 Prosub/sub Uncus
Ventral Figure 3 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal 7 7 7 6 6 ! ! 6 ! Medial Lateral Medial Lateral Medial Lateral 2 2 2
Ventral Ventral Ventral e f g
Lateral External Digitation 7 Lateral External Digitation 6 4 5 Figure 4 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal 7 7 7 ! * * ! * ! * * * * * VHS > Medial Lateral Medial Lateral Medial 2 Lateral VHS > VHS > VHS VHS
2 2 Ventral Ventral Ventral e f g Lateral External Digitation Lateral External Digitation Figure 5 US - Uncul Sulcus Legend Subregions a VHS - Vestigial Hippocampal Sulcus DG/CA4 HATA Hippocampo-amygdalar Transition Area CA3/2 > - Dorsal Extent of VHS ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria Pre/parasubiculum # - Dorsolateral Extent of Lateral Uncul Sulcus / Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal ! 7 ! 7 > 7 ! US > CSF > VHS Medial Lateral Medial * VHS Lateral Medial VHS Lateral * VHS * ^ 2 * VHS VHS ^ 2 ^ 2
Ventral Ventral Ventral e g Lateral External Digitation f Lateral External Digitation 8 7 DG 4 : : : 6 5 Figure 6 US - Uncul Sulcus Legend Subregions a VHS - Vestigial Hippocampal Sulcus DG/CA4 HATA Hippocampo-amygdalar Transition Area CA3/2 > - Dorsal Extent of VHS ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria Pre/parasubiculum # - Dorsolateral Extent of Lateral Uncul Sulcus / Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal ! 7 ! > VHS > VHS ! US 7 7 VHS CSF >
Medial Lateral Medial Lateral Medial VHS Lateral * 2 * * ^ * * ^ VHS * ^ VHS 2 2 Ventral Ventral Ventral e f g Lateral External Digitation Lateral External Digitation 8 7 1 : : : Figure 7 US - Uncul Sulcus Legend Subregions a VHS - Vestigial Hippocampal Sulcus DG/CA4 HATA Hippocampo-amygdalar Transition Area CA3/2 > - Dorsal Extent of VHS ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria Pre/parasubiculum # - Dorsolateral Extent of Lateral Uncul Sulcus / Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal 7 ! ! > VHS 7 > VHS ! CSF US 7 > VHS VHS Medial Lateral Medial Lateral Medial ^ 2 Lateral * * * * ^ VHS * * ^ VHS 2 2
Ventral Ventral Ventral e Lateral External Digitation f g Lateral External Digitation
8 7 : : : Figure 8 US - Uncul Sulcus Legend Subregions a VHS - Vestigial Hippocampal Sulcus DG/CA4 HATA Hippocampo-amygdalar Transition Area CA3/2 > - Dorsal Extent of VHS ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria Pre/parasubiculum # - Dorsolateral Extent of Lateral Uncul Sulcus / Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal ! ! > VHS > VHS ! US CSF 7 >VH S # Medial # Lateral Medial Lateral Medial VHS Lateral * * * VHS # ^ 2 ^ * ^ VHS 2 * * 2
Ventral Ventral Ventral
e Lateral External Digitation f g Lateral External Digitation
8 7 : : Figure 9 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal ! ! > VHS > VHS ! US CSF > # VHS # # Medial Lateral Medial * Lateral Medial ^ VHS Lateral * * * * * ^ VHS * * * * ^ VHS 2 2 2
Ventral Ventral Ventral e Lateral External Digitation f g Lateral External Digitation
: : Figure 10 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal ! ! CSF VHS > VHS > (dark patch = blood vessel) US # # ! # >VH S * ^ Medial * * * VHS Lateral Medial * Lateral Medial VHS Lateral * * * ^ VHS ^ 2 2 2
Ventral Ventral Ventral e Lateral External Digitation f g
Lateral External Digitation
: : Figure 11 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal % ! ! > VHS > VHS # % ! # % * * # > * * * ^ VHS * ^ VHS * VHS * * ^ VHS Medial Lateral Medial * 2 Lateral Medial 2 Lateral 2
Ventral Ventral Ventral e f g
%
: : Figure 12 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
Dorsal Dorsal d Dorsal b c ! % ! % # % ! # # VHS > >VH S ^ VHS >VH S Medial * * Lateral Medial * * ^ Lateral Medial Lateral ^ VHS VHS
Ventral Ventral Ventral e f g
: Figure 13 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal % Dorsal portion of hippocampus Dorsal portion of % % hippocampus ! # % # Dorsal portion of # ! hippocampus Medial > Lateral Medial Lateral Medial ^ VHS > Lateral ^ VHS > VHS VHS ^ VHS VHS
Ventral Ventral Ventral
e f g %
%
: Figure 14 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal Dorsal portion of hippocampus DG
Dorsal portion of Dorsal portion of hippocampus hippocampus VHS VHS Medial Lateral Medial Lateral Medial Lateral
Ventral Ventral Ventral
e f g 9
DG : : 10 Figure 15 Legend Subregions US - Uncul Sulcus a DG/CA4 VHS - Vestigial Hippocampal Sulcus > - Dorsal Extent of VHS CA3/2 ^ - Ventral Extent of VHS CA1 * - Islands indicating Presubiculum Prosubiculum/subiculum % - Fimbria # - Dorsolateral Extent of Lateral Uncul Sulcus / Pre/parasubiculum Ventromedial Extent of the Fimbria Uncus ! Medial Extent of the Lateral External Digitation Vestigial Hippocampal Sulcus
b Dorsal c Dorsal d Dorsal
Medial Lateral Medial Lateral Medial Lateral
Ventral Ventral Ventral
Isthmus/retrosplenial cortex e Isthmus/retrosplenial cortex f g Dorsal portion of Isthmus/retrosplenial cortex hippocampus a b c d e f
12 7 11
Subregions Uncus 12 7 Prosubiculum/subiculum 11 CA1
Pre/parasubiculum Wall of the Anterior Figure 16 Hippocampus / VHS Anterior - Posterior Figure 17 Examples of VHS Cavities Example of the Ventral Extension of the VHS a c d
Ventral extension of VHS VHS cavity Ventral extension of VHS
Subregions b e f DG/CA4 CA3/2 CA1 Prosubiculum/subiculum VHS cavity Pre/parasubiculum Uncus Vestigial Hippocampal Sulcus / Ventral Extension of the VHS a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i k l Uncus j
Figure 18 Anterior - Posterior a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i j k l Uncus
Figure 19 Anterior - Posterior a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i j k l Uncus
Figure 20 Anterior - Posterior a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i j k l Uncus
Figure 21 Anterior - Posterior a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i j k l Uncus
Figure 22 Anterior - Posterior a b c d e f DG/CA4
CA3/2
CA1
Prosub/ sub
Pre/ parasub
g h i j k l Uncus
Figure 23 Anterior - Posterior a b c d e DG/CA4
CA3/2
CA1 Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex
Prosub/ sub
Pre/ parasub Anterior - Posterior Uncus Figure 24 Example of consistent subiculum length (yellow) along anterior-posterior axis posterior hippocampus DG/CA4 Posterior
CA3/2
CA1
Medial Lateral
Prosub/sub
Pre/parasub
Anterior
Uncus Figure 25 a DG/CA4 b c d
CA3/2
CA1 Posterior Cerebral Artery Prosub/ sub 3. 2. 2. 1. 4. 3. 1. Pre/ * parasub
Uncus Figure 26 a b c d DG/CA4
CA3/2 * * ^ * ^ CA1
Prosub/ e f g h sub
Pre/ parasub * ^ * ^ * ^ Uncus
Figure 27 Anterior - Posterior Figure 28 a b c d e f g h
DG/CA4 Dorsal portion of Dorsal portion of hippocampus hippocampus
CA3/2
Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex
CA1 i j k l m n o p
Prosub/ sub Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of hippocampus hippocampus hippocampus hippocampus hippocampus hippocampus hippocampus
Pre/ parasub
Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Anterior - Posterior Figure 29 a b c d e f
DG/CA4 Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of hippocampus hippocampus hippocampus hippocampus
CA3/2
Isthmus/retrosplenial cortex CA1 g h i j k l
Prosub/ sub Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of Dorsal portion of hippocampus hippocampus hippocampus hippocampus hippocampus hippocampus Pre/ parasub
Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Isthmus/retrosplenial cortex Anterior - Posterior