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Appendix: WHO Classification of Tumors of the Pancreas 2019

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Appendix: WHO Classification of Tumors of the Pancreas 2019 Appendix: WHO Classifcation of Tumors of the Pancreas 2019 (Modifed from Lokuhetty D, White VA, • Mucinous cystic neoplasm with low-grade Watanabe R, Cree IA (eds). Digestive system dysplasia tumors. WHO classifcation of tumors 5th edi- • Mucinous cystic neoplasm with high-grade tion. Lyon: IARC Press; 2019, p. 296) dysplasia • Mucinous cystic neoplasm with associated invasive carcinoma Benign Epithelial Tumors and Precursors Malignant Epithelial Tumors • Serous cystadenoma NOS –– Macrocystic (oligocystic) serous cysta­ • Ductal adenocarcinoma NOS denoma –– Colloid carcinoma –– Solid serous adenoma –– Signet-ring cell (poorly cohesive cell) –– Von Hippel-Lindau syndrome-associated carcinoma serous cystic neoplasm –– Medullary carcinoma –– Mixed serous-neuroendocrine neoplasm –– Adenosquamous carcinoma • Serous cystadenocarcinoma NOS –– Hepatoid carcinoma • Glandular intraepithelial neoplasia, low grade –– Invasive micropapillary carcinoma • Glandular intraepithelial neoplasia, high –– Carcinoma, undifferentiated, NOS grade –– Undifferentiated carcinoma with • Intraductal papillary mucinous neoplasm with osteoclast-­like giant cells low-grade dysplasia • Acinar cell carcinoma • Intraductal papillary mucinous neoplasm with –– Acinar cell cystadenocarcinoma high-grade dysplasia –– Mixed acinar cell carcinoma-neuroendo- • Intraductal papillary mucinous neoplasm with crine carcinoma associated invasive carcinoma –– Mixed acinar cell carcinoma-ductal adeno- • Intraductal oncocytic papillary neoplasm carcinoma-neuroendocrine carcinoma NOS –– Mixed acinar-ductal carcinoma • Intraductal oncocytic papillary neoplasm with • Pancreatoblastoma associated invasive carcinoma • Solid pseudopapillary neoplasm of the • Intraductal tubulopapillary neoplasm pancreas • Intraductal tubulopapillary neoplasm with –– Solid pseudopapillary neoplasm with high-­ associated invasive carcinoma grade carcinoma © Springer Nature Switzerland AG 2021 F. Campbell, C. S. Verbeke, Pathology of the Pancreas, 433 https://doi.org/10.1007/978-3-030-49848-1 434 Appendix: WHO Classifcation of Tumors of the Pancreas 2019 Pancreatic Neuroendocrine –– Gastrinoma Neoplasms –– VIPoma –– Glucagonoma • Pancreatic neuroendocrine microadenoma –– Somatostatinoma • Neuroendocrine tumor NOS –– ACTH-producing tumor –– Neuroendocrine tumor, grade 1 –– Enterochromaffn-cell carcinoid –– Neuroendocrine tumor, grade 2 –– Serotonin-producing tumor –– Neuroendocrine tumor, grade 3 • Neuroendocrine carcinoma NOS • Pancreatic neuroendocrine tumor, –– Large cell neuroendocrine carcinoma nonfunctioning –– Small cell neuroendocrine carcinoma –– Oncocytic neuroendocrine tumor, • Mixed neuroendocrine—non-neuroendocrine ­nonfunctioning pancreatic neoplasm (MiNEN) –– Pleomorphic neuroendocrine tumor, –– Mixed ductal adenocarcinoma-neuroendo- ­nonfunctioning pancreatic crine carcinoma –– Clear cell neuroendocrine tumor, –– Mixed ductal adenocarcinoma-­ ­non­functioning pancreatic neuroendocrine tumor –– Cystic neuroendocrine tumor, –– Mixed acinar cell carcinoma-­ ­nonfunctioning pancreatic neuroendocrine carcinoma • Functioning pancreatic neuroendocrine tumors –– Mixed acinar cell carcinoma-ductal adeno- –– Insulinoma carcinoma-neuroendocrine carcinoma Index A Alpha-cell hyperplasia, 357 Acinar cell, 11 Alpha-fetoprotein, 185, 209, 212 carcinoma, 175, 203–214, 302, 341 Ampulla, 9 carcinoma cytology, 413–417 minor, 10, 21–22, 44, 274 cystadenocarcinoma, 210, 308 oozing mucin, 140, 274 cystadenoma, 305–308 swollen, 115 nodule, 67 vallecula, 21 Acinar cystic transformation, 305–308 of Vater (major), 9, 19–21, 44 Acinar dilatation (ectasia), 67 Ampullary cancer, 177 Acinar to ductal metaplasia, see Metaplasia Amylase, 12, 207 Acini, 11 Amyloid, 73, 132, 332 Acute pancreatitis, 87–92 Anastomosis, 25, 30 complications, 92 Anatomy, 5–11 etiology, 88 Angiolipoma, 217, 219 fbrosis, 96 Angiomatoid pattern (PanNET), 327 infectious, see Infection Angiomyolipoma, 219 mild (edematous/interstitial), 87, 90 Anterior surface (pancreas), 39, 47, 170 severe (hemorrhagic), 87, 90, 91 Artery recurrent, 93, 95, 102, 104, 235 gastroduodenal, 10, 47 Adenocarcinoma of pancreas, see Ductal hepatic, 25, 194 adenocarcinoma pancreatic, 10 Adenomyoma(tosis), 124, 126 pancreatoduodenal,10, 47 Adenomyosis, 238 splenic, 7, 10, 55 Agenesis and hypoplasia, 236 superior mesenteric (SMA), 6, 10, 26, 27, 47, 194 Alcohol abuse, 105, 124, 238 Ataxia telangiectasia, 82 Allograft (pancreas), 31, 127, 363, 364, 367, 371, 380 Atrophy, 95 Allograft rejection, 127 acinar, 95, 100, 110 acute cellular, 367, 371–375 lobulocentric, 70, 71, 83–84, 96, 140 arteritis, 373 ATRX, 321 ductitis, 373 Audit, 63 grading, 374–375 Autoimmune isletitis, 382 venulitis, 371 Autoimmune pancreatitis (AIP), 105–120, 123, 127, 129, antibody-mediated, 368–371 132, 394 acute, 369–370 cytology, 419–421 chronic active, 370 diagnostic algorithm, 118–120 C4d, 364, 370, 378, 379 differential diagnosis, 116–118 chronic, 367, 375–378 distinction from follicular pancreatitis, 129 staging, 376–377 eosinophils, 109, 127 chronic active cell-mediated, 375 etiology, 107 chronic allograft arteriopathy, 377–378 focal, 107 differential diagnosis, 379–380 frozen section, 394 hyperacute, 368–369 granulocytic epithelial lesion, 112 Alpha-1-antitrypsin, 208 idiopathic duct-centric pancreatitis, 107 Alpha-cell, 15, 376 IgG immunohistochemistry, 114 © Springer Nature Switzerland AG 2021 435 F. Campbell, C. S. Verbeke, Pathology of the Pancreas, https://doi.org/10.1007/978-3-030-49848-1 436 Index Autoimmune pancreatitis (AIP) (cont.
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