NOMO1 Rabbit Pab

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Leader in Biomolecular Solutions for Life Science NOMO1 Rabbit pAb Catalog No.: A10510 Basic Information Background Catalog No. This gene encodes a protein originally thought to be related to the collagenase gene A10510 family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that Observed MW may have the same function. The protein encoded by one of these genes has been 134kDa identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather Calculated MW than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). 134kDa Category Primary antibody Applications WB, IHC Cross-Reactivity Human, Mouse, Rat Recommended Dilutions Immunogen Information WB 1:1000 - 1:2000 Gene ID Swiss Prot 23420 Q15155 IHC 1:50 - 1:200 Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human NOMO1 (NP_055102.3). Synonyms NOMO1;Nomo;PM5 Contact Product Information www.abclonal.com Source Isotype Purification Rabbit IgG Affinity purification Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. Validation Data Western blot analysis of extracts of various cell lines, using NOMO1 antibody (A10510) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. Immunohistochemistry of paraffin- Immunohistochemistry of paraffin- embedded human colon carcinoma using embedded rat brain using NOMO1 Rabbit NOMO1 Rabbit pAb (A10510) at dilution of pAb (A10510) at dilution of 1:350 (40x 1:350 (40x lens). lens). Antibody | Protein | ELISA Kits | Enzyme | NGS | Service For research use only. Not for therapeutic or diagnostic purposes. Please visit http://abclonal.com for a complete listing of recommended products..

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Genetic Epidemiology
Received: 10 May 2019 | Revised: 31 July 2019 | Accepted: 28 August 2019 DOI: 10.1002/gepi.22260 RESEARCH ARTICLE Population‐wide copy number variation calling using variant call format files from 6,898 individuals Grace Png1,2,3 | Daniel Suveges1,4 | Young‐Chan Park1,2 | Klaudia Walter1 | Kousik Kundu1 | Ioanna Ntalla5 | Emmanouil Tsafantakis6 | Maria Karaleftheri7 | George Dedoussis8 | Eleftheria Zeggini1,3* | Arthur Gilly1,3,9* 1Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Abstract Kingdom Copy number variants (CNVs) play an important role in a number of human 2Department of Medical Genetics, diseases, but the accurate calling of CNVs remains challenging. Most current University of Cambridge, Cambridge, approaches to CNV detection use raw read alignments, which are computationally United Kingdom intensive to process. We use a regression tree‐based approach to call germline CNVs 3Institute of Translational Genomics, Helmholtz Zentrum München—German from whole‐genome sequencing (WGS, >18x) variant call sets in 6,898 samples Research Center for Environmental across four European cohorts, and describe a rich large variation landscape Health, Neuherberg, Germany comprising 1,320 CNVs. Eighty‐one percent of detected events have been previously 4European Bioinformatics Institute, ‐ ‐ Wellcome Genome Campus, Hinxton, reported in the Database of Genomic Variants. Twenty three percent of high quality United Kingdom deletions affect entire genes, and we recapitulate known events such as the GSTM1 5William Harvey Research Institute, Barts and RHD gene deletions. We test for association between the detected deletions and and The London School of Medicine and 275 protein levels in 1,457 individuals to assess the potential clinical impact of the Dentistry, Queen Mary University of London, London, United Kingdom detected CNVs.
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