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Applied AI and Machine Learning in Translational Medicine
This is a repository copy of Looking beyond the hype : applied AI and machine learning in translational medicine. White Rose Research Online URL for this paper: http://eprints.whiterose.ac.uk/151087/ Version: Published Version Article: Toh, T.S., Dondelinger, F. and Wang, D. (2019) Looking beyond the hype : applied AI and machine learning in translational medicine. EBioMedicine. ISSN 2352-3964 https://doi.org/10.1016/j.ebiom.2019.08.027 Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/ Takedown If you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing [email protected] including the URL of the record and the reason for the withdrawal request. [email protected] https://eprints.whiterose.ac.uk/ EBIOM-02366; No of Pages 9 EBioMedicine xxx (2019) xxx Contents lists available at ScienceDirect EBioMedicine journal homepage: www.ebiomedicine.com Review Looking beyond the hype: Applied AI and machine learning in translational medicine Tzen S. Toh a, Frank Dondelinger b, Dennis Wang c,d,⁎ a The Medical School, University of Sheffield, Sheffield, UK b Lancaster Medical School, Furness College, Lancaster University, Bailrigg, Lancaster, UK c NIHR Sheffield Biomedical Research Centre, University of Sheffield, Sheffield, UK d Department of Computer Science, University of Sheffield, Sheffield, UK article info abstract Article history: Big data problems are becoming more prevalent for laboratory scientists who look to make clinical impact. -
The Field Courses of the Royal Meteorological Society
OCCASIONAL PAPERS ON METEOROLOGICAL HISTORY No.17 THE FIELD COURSES OF THE ROYAL METEOROLOGICAL SOCIETY MALCOLM WALKER Published by The Royal Meteorological Society’s History of Meteorology and Physical Oceanography Special Interest Group OCTOBER 2015 ISBN: 978-0-948090-41-7 ROYAL METEOROLOGICAL SOCIETY 104 OXFORD ROAD – READING – RG1 7LL – UNITED KINGDOM Telephone: +44 (0)118 956 8500 Fax: +44 (0)118 956 8571 E-mail: [email protected] Web: http://www.rmets.org Registered charity number 208222 © Royal Meteorological Society 2015 i THE FIELD COURSES OF THE ROYAL METEOROLOGICAL SOCIETY Malcolm Walker Royal Meteorological Society October 2015 View across Malham Tarn at about 8pm on 28 July 1959, showing a large cumulus which shortly afterwards showed a marked anvil formation. Photograph by Nancy J Gordon published in Weather, February 1961, 16, 2, p.45. ii iii CONTENTS LIST OF ILLUSTRATIONS ...................................................................................................... v SUMMARY .................................................................................................................................... 1 PART 1 – The formative years POST-WAR ANTECEDENTS ............................................................................................................ 2 THE PIONEER FIELD COURSE ......................................................................................................... 3 TWO COURSES IN 1951 ................................................................................................................ -
Abstracts from the Research Symposium for Medical Students and Foundation Doctors 20 November 2019
Abstracts from the Research Symposium for Medical Students and Foundation Doctors 20 November 2019 November 2019 This abstract book has been produced using author-supplied copy and no editing has been undertaken. No responsibility is assumed for any claims, instructions, methods or drug dosages included in the abstracts: it is recommended that these are verified independently. Undergraduate Prizes Best undergraduate oral presentation Socioeconomic differences in cardiovascular disease risk factor prevalence in people with type 2 diabetes in Scotland: a cross-sectional study Edward Whittaker (Supervisor: Prof. Sarah Wild) University of Edinburgh INTRODUCTION: Health inequalities exist in outcomes of diabetes in different socioeconomic groups and these are particularly marked for cardiovascular disease and its risk factors1. The aim of this study was to describe the association between socioeconomic status and prevalence of cardiovascular risk factors (smoking, body mass index, HbA1C, blood pressure and cholesterol) in people with type 2 diabetes in contemporary Scottish data. PATIENTS AND METHODS: A cross-sectional study was performed of 264,011 people with type 2 diabetes in Scotland who were alive on 30/06/16, identified from the population-based diabetes register. Socioeconomic status was defined using quintiles of the area-based SIMD with Q1 and Q5 used to identify the most and least deprived fifths of the population respectively. Logistic regression models adjusted for age, sex, health board, history of cardiovascular disease and duration of diabetes were used to estimate odds ratios (OR) (and 95% confidence intervals) for Q1 compared to Q5 for each risk factor. RESULTS: The mean (SD) age of the study population was 66.7 (12.8) years, 56.1% were men, 23.6% were in Q1 and 15.1% in Q5. -
Embedding Physical Activity in the Undergraduate Curriculum
July 2018 Embedding physical activity in the undergraduate curriculum Commissioned by Public Health England (PHE) and Sport England to embed physical activity in the undergraduate curricula in a sample of medical schools and schools of health in England during 2017 and 2018. This is part of the PHE & Sport England’s Moving Healthcare Professionals Programme Authors on behalf of Exercise Works Ltd Ann B. Gates MRPharmS BPharm (Hons) Ian K. Ritchie FRCSEd Executive Summary July 2018 movement for movement Forewords A final year medical student’s view on the lack of exercise medicine in undergraduate curricula As a medical student about to graduate, I have been left disappointed by the lack of exercise medicine I have been exposed to during my time at medical school. Despite it being a well-established way to prevent, treat and manage illness, exercise medicine does not feature significantly in medical curricula throughout the United Kingdom. As a result, there is lack of knowledge and awareness in the medical community. This issue is not limited to doctors: all allied health care professionals are in a position to influence positive lifestyle changes and all should be exposed to exercise medicine in their undergraduate curricula. We are currently missing out on a fantastic opportunity to empower the health care professionals of the future to be confident in advising patients about utilising exercise to improve their health and quality of life. This commission report demonstrates that physical activity can be successfully integrated into medical school curricula, and that students can encourage and support this being implemented. Katie Marino Final year medical student, University of Sheffield. -
Campus Map CAMPUS
Forrest Hills SOUTH EAST Lancaster University Campus Map CAMPUS NORTH CAMPUS FURNESS AVE B TOWER AVE E C PHYSICS AVE ISO JOHN CREED AVE COUNTY AVE Bailrigg Service Station LANCASTER SQUARE AVE CTP Maintenance GEORGE FOX AVE UNDERPASS Workshops COM PHS WWB County College FYLDE AVE SOUTH CHE CAMPUS D ISS COS The PSC Orchard FAR Bonington Square Step Lancaster TRH Square FAS SBH GFX INF Physics Garden Cycle Route to NORTH DRIVE Fylde College Ellel & Galgate Great Edward SOUTH DRIVE Hall BLN BLM Roberts Court GHC Court Bowland Bowland FUR Wetland North Quad Fylde Grizedale College Quad WEL Furness College Quad Furness Alexandra College Court FYL SAT LIC Square Pendle College Welcome LEC Great Hall Centre CHC Square Reception Engineering F Square Cycle Route to PENDLE AVE ASH Bowland College City Centre BLA Students’ Union ROSSENDALE AVE LIB ENG LSE BLH A Arrival UNH Point University GRIZEDALE AVE House MAN Reception BOWLAND AVE G Graduate College HRB UNDERPASS CPC BOWLAND AVE FARRER AVE GILLOW AVE F Graduate BRH LIBRARY AVE SEC Square A GRADUATE AVE LCC CARTMEL AVE Netball Courts South West I Campus ALEXANDRA PARK DRIVE Barker NORTH WEST RUS House BHF Entrance Lancaster Court House Hotel CAMPUS H Cartmel College Rugby League Pitch PARK BOULEVARD Lacrosse Pitch ECO BARKER HOUSE AVE MED J PRE Lonsdale SOUTH WEST CAMPUS Quad LONSDALE AVE HAZELRIGG LANE Lonsdale College BFB Lake Carter Grass Playing Pitch Astro Turf Pitch L Grass Playing Pitch L Grass Playing Pitch Grass Playing Pitch Grass Playing Pitch 3rd Generation Artificial Pitch Astro Turf -
LANCASTER UNIVERSITY CAMPUS MAP Accessible Route Motorcycle Parking Roads Accessible Parking E Walkways Electrical Charging Point N B the Spine Refreshments B
1 2345678910111213141516 A KEY Pay & Display machines A LANCASTER UNIVERSITY CAMPUS MAP Accessible Route Motorcycle Parking Roads Accessible Parking E Walkways Electrical charging point N B The Spine Refreshments B S B Footpath / cycle route Visitor Toilet B e W nue nu e Woodland Trail Baby Change . e . 49 e e 41 e ast Driv e Av ue u ue ve C e Sout Av n 29a North E u Av Av A A h East ss ss en en op) n t Bridleways e ve d d d er E Cycle Parking 19 19a e D S e riv n v Av Av A 49 w e ee ee e s A s r 29 29 o u cs cs 2 . T C C i Fur x Cr A e si o Visitor car parks A - L n One way system e t y ysi F l 29 s (B s hn a Av h h as s e ohn oh E P P y y a J Jo J nd g . t e r e s n C ue B C o Closed during development Bus Stops Av u os e 20 n 50 R o derp e 29 G 7 C 40 Av 27 Un D Open during development T 60 Taxi Rank 27a 48 Fylde re 18 ster Squa 27 41 Lanca 21 0 100m 200m 3 8 30 39 51 55 e v i . 61 62 300ft 600ft Sq ive 17 a North Spine r 9 d 38 D n D 42a Dr South a 61 25 47 e route to ex 42 Cycl l 47a 16 37 57 lgate 28 A Ellel & Ga North Dr North 10 Great Hall 23 outh Spine 11 31 S B 54 28a e 4 nu Stairs/Lift to 43a e underpass F Forrest Hills top bus s Av 28 e t 15 l H es 14 36 a 1 mile nd z University e W l A House . -
Short-Term Forecasts to Inform the Response to the Covid-19 Epidemic in the UK
medRxiv preprint doi: https://doi.org/10.1101/2020.11.11.20220962; this version posted December 4, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license . Short-term forecasts to inform the response to the Covid-19 epidemic in the UK 1* 1 2 3 4,5 6,7 6 1 8 Funk S , Abbott S , Atkins BD , Baguelin M , Baillie JK , Birrell P , Blake J , Bosse NI , Burton J , 7 1 6,7 2 1 1 3 Carruthers J , Davies NG , De Angelis D , Dyson L , Edmunds WJ , Eggo RM , Ferguson NM , 3 2 2 1 2 2 9 10 Gaythorpe K , Gorsich E , Guyver-Fletcher G , Hellewell J , Hill EM , Holmes A , House TA , Jewell C , 1 1 11 2 12 3 1 13 Jit M , Jombart T , Joshi I , Keeling MJ , Kendall E , Knock ES , Kucharski AJ , Lythgoe KA , Meakin 1 1 14 9 9 11 3 9,15 SR , Munday JD , Openshaw PJM , Overton CE , Pagani F , Pearson J , Perez-Guzman PN , Pellis L , 16 17,18 1 12 2 7 3,7 Scarabel F , Semple MG , Sherratt K , Tang M , Tildesley MJ , Van Leeuwen E , Whittles LK , CMMID COVID-19 Working Group, Imperial College COVID-19 Response Team, ISARIC4C Investigators 1 Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, Keppel St, London, WC1E 7HT, UK 2 The Zeeman Institute for Systems Biology & Infectious Disease -
LU Campus Map.Indd
Lancaster Campus E NORTH CAMPUS SOUTH EAST CAMPUS Forrest Hills 0.5 Miles B C ISO Maintenance E Workshops N S Garage & Fuel Station CTP COM PHS WWB County W College CHE ISS The PS D COS FAR Bonington C Lancaster Step Square TRH Physics FAS SBH GFX INF Garden SOUTH CAMPUS Cycle Route to North Spine Fylde Ellel & Galgate Great Edward College Hall BLN BLM Roberts Court Bowland Court Furness Fylde Grizedale North FUR GHC Bowland College Quad College Quad WEL Quad BLE Pendle Alexandra South Spine Furness FYL SAT College LIC Square College Court Great Welcome CHC Hall Centre Engineering Cycle Square Reception Bowland Square F Route to ASH College City BLA Students’ Union Centre LIB ENG Arrival LEC BLH A Point UNH LSE University House Reception Graduate College E HRB MAN V CPC A E T BRH A U D Graduate A SEC R E G Square G I AV ALEXANDRA EL South A RTM LCC CA West S Campus Entrance RU Lancaster BHF Lacrosse Pitch House Hotel PARK DRI Barker NORTH WEST RD House Cartmel H ULEVA RK BO Court College RA PA ALEXAND H CAMPUS KER O ECO VE Lonsdale BAR U S D Quad E J ME A PRE VE LO NSD Lonsdale ALE Rugby League College A Pitch BFB V Lake Carter Grass Pitch E M Astro Turf L HIO L Grass Pitches Bowling Green SOUTH WEST 3G Artificial Pitch Astro Turf SPC CAMPUS Grass Pitches Cycle K Route to City Grass Playing Pitch Centre Grass Playing Pitch Tennis Courts M6 Junction 33 e ANCE Lancas ter City Centr MAIN ENTR ANCE HEALTH INNOVATION CAMPUS ENTR SYMBOL KEY WALKS & ROUTES CAMPUS ZONES Accessible Parking co Colleges Library Shops/Refreshments Cycle Route North -
Knowing Weather in Place: the Helm Wind of Cross Fell
Veale, L., Endfield, G., and Naylor, S. (2014) Knowing weather in place: the Helm Wind of Cross Fell. Journal of Historical Geography, 45 . pp. 25-37. ISSN 0305-7488 Copyright © 2014 The Authors http://eprints.gla.ac.uk/99540 Deposited on: 19 November 2014 Enlighten – Research publications by members of the University of Glasgow http://eprints.gla.ac.uk Journal of Historical Geography 45 (2014) 25e37 Contents lists available at ScienceDirect Journal of Historical Geography journal homepage: www.elsevier.com/locate/jhg Knowing weather in place: the Helm Wind of Cross Fell Lucy Veale a,*, Georgina Endfield a and Simon Naylor b a University of Nottingham, School of Geography, University Park, Nottingham NG7 2RD, UK b University of Glasgow, School of Geographical and Earth Sciences, East Quadrangle, University Avenue, Glasgow G12 8QQ, UK Abstract The Helm Wind of Cross Fell, North Pennines, is England’s only named wind. As a product of the particular landscape found at Cross Fell, the Helm is a true local wind, and a phenomenon that has come to assume great cultural as well as environmental significance in the region and beyond. In this paper we draw on material from county histories, newspaper archives, and documents relating to investigations of the Helm Wind that were conducted by the Royal Meteorological Society between 1884 and 1889, and by British climatologist Gordon Manley (1908e1980), between 1937 and 1939, to document attempts to observe, measure, understand and explain this local wind over a period of 200 years. We show how different ways of knowing the Helm relate to contemporary practices of meteorology, highlighting the shifts that took place in terms of what constituted credible meteorological observation. -
Fresh 2012.Indd
Welcome to Lancaster Popular legend has it that once you have lived in Lancaster you’ll either never leave, or have to keep coming back. Whether or not that’s true in your case only ti me will tell, but in the meanti me you’ve got three or four years of life changing excitement, personal evoluti on, good ti mes, new friendships and relati onships, and at ti mes, more than a litt le bit of hard work to be going on with. Freshers’ Week at Lancaster is an energeti c and fun packed week aimed at easing you into student life, and this guide details the main events run by the University, the Students’ Union (LUSU), and any other notable events run for everyone. Keep it safe: You’ll need this to know where to go, what to do and when you should be doing it. University is as much about the experience as it is about getti ng a degree - you’ll get a lot out of it, and there’s always the opportunity to put a lot back into it. Those Freshers’ Reps you meet on day one were probably in your positi on last year, and could be the fi rst of many friends you make here. The JCR Exec are all current students that will be around all week to look aft er you, and don’t forget about your College Offi cers and your College Advisor: These people may be staff members but they also put a lot into making sure that your student experience is as good as it can be. -
Abstracts from the Medical Research Symposium for Students and Foundation Doctors 21 November 2018
Abstracts from the Medical Research Symposium for Students and Foundation Doctors 21 November 2018 November 2018 This abstract book has been produced using author-supplied copy and no editing has been undertaken. No responsibility is assumed for any claims, instructions, methods or drug dosages included in the abstracts: it is recommended that these are verified independently. Undergraduate Prizes Best undergraduate oral presentation Comparing Outcomes of Stent Retriever Thrombectomy versus Direct Aspiration for the Endovascular Treatment of Acute Anterior Circulation Stroke SE Thompson, R Jones, K Nader Birmingham Medical School Introduction Endovascular therapy with a stent retriever has been shown to be superior to standard medical therapy in the treatment of acute ischaemic stroke and is recommended by the American Stroke Association. Direct aspiration thrombectomy is another commonly used method increasing in popularity with advances in catheter technology. Few studies have directly compared the efficacy of the two methods, with current evidence equivocal. This study compares the stent retriever and direct aspiration methods. Patients and methods 101 patients presenting to the Queen Elizabeth Hospital Birmingham between January 2013-November 2017 with anterior circulation ischaemic stroke, fulfilling the criteria for endovascular therapy, were retrospectively analysed. 45 patients underwent first-line stent retriever thrombectomy and in 56 patients, direct aspiration was the primary method. The primary outcome was successful revascularization (TICI 2b/3) and secondary outcomes included procedural and clinical measures. Results Successful revascularization was achieved more frequently when direct aspiration was the primary chosen method (91.1% vs. 57.8%, p=0.000) and was significantly more likely to be successful with a single pass (p=0.005). -
Lancaster University Annual Report and Accounts 2011
LAncAsteR UniveRsity AnnUAL RepoRt And AccoUnts 2011 Lancaster University 1 1 Lancaster 0 2 LA1 4YW s t United Kingdom n u o c T: +44(0)1524 65201 c A www.lancs.ac.uk d n a ISBN 978-1-86220-290-0 t r o p e R y t i s r e v i n U r e t s a c n a L Lancaster University has been awarded the Carbon Trust Standard after taking action on climate change by reducing carbon emissions. The University has made an overall reduction of 245 tonnes of carbon or 0.9% averaged over the past three years. Lancaster University 1 Contents Vice-Chancellor’s review 2 Pro-Chancellor’s review 4 High notes of the year 6 A global university 12 Awards and distinctions 18 Advancing knowledge through research 30 Key facts and figures 42 Financial Statements 46 Operating and Financial Review for the year ended 31 July 2011 48 Statement of Corporate Governance 56 Independent Auditors’ Report to the Council of Lancaster University 61 Statement of Accounting Policies 62 Consolidated Income and Expenditure Account 64 Statement of Consolidated Historical Cost Surpluses and Deficits 65 Balance Sheets as at 31 July 20 11 66 Consolidated Cash Flow Statement 67 Reconciliation of Net Cash Flow to movement in Net Debt 68 Consolidated Statement of Total Recognised Gains and Losses 69 Notes to the Financial Statements 70 Chancellor’s Guild roll of honour 92 Chancellor’s Guild corporate donors and legacy pledges 93 Trusts, foundations and charities 94 Organisational chart 95 Lancaster University Report and Accounts 2011 3 ViCe-ChanCellor’s reView The growing reputation of Lancaster was marked this year by top ten placings in each of the UK’s major university been strengthened with a formal respond to this feedback to make sure The Government’s White Paper “Students collaboration with the Chinese Academy every department is outstanding.