Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GIPC3 ENST00000322315.5 GIPC PDZ domain containing family, member 3 48 14 5 5 4 9 hsa-miR-5001-5p -4.18 -4.18 N/A

GNG13 ENST00000248150.4 guanine nucleotide binding protein (G protein), gamma 13 5 7 0 7 0 0 hsa-miR-4498 -2.21 -2.21 N/A

EVC ENST00000382674.2 Ellis van Creveld syndrome 165 15 0 15 0 1 hsa-miR-4498 -2.1 -2.1 N/A MAM domain containing glycosylphosphatidylinositol MDGA1 ENST00000297153.7 240 7 3 3 1 5 hsa-miR-5001-5p -2.05 -2.11 N/A anchor 1 KLK4 ENST00000324041.1 kallikrein-related peptidase 4 5 9 0 9 0 0 hsa-miR-4498 -1.77 -1.77 N/A

OLFML2A ENST00000288815.5 olfactomedin-like 2A 155 9 4 4 1 1 hsa-miR-4498 -1.77 -1.77 N/A

SDK2 ENST00000392650.3 sidekick cell adhesion molecule 2 8 5 3 2 0 2 hsa-miR-4498 -1.74 -1.74 N/A

NKIRAS2 ENST00000462043.2 NFKB inhibitor interacting Ras-like 2 9685 4 1 3 0 1 hsa-miR-5001-5p -1.71 -1.71 N/A

OSBP2 ENST00000382310.3 oxysterol binding protein 2 485 6 2 4 0 0 hsa-miR-5001-5p -1.64 -1.66 N/A

SNPH ENST00000381873.3 syntaphilin 13 5 2 2 1 1 hsa-miR-4498 -1.61 -1.61 N/A

SPN ENST00000360121.3 sialophorin 5 3 2 0 1 3 hsa-miR-5001-5p -1.58 -1.58 N/A

PER2 ENST00000254658.3 period circadian clock 2 106 4 2 1 1 3 hsa-miR-4498 -1.57 -1.57 N/A

FLJ27365 ENST00000360737.3 hsa-mir-4763 74 5 2 3 0 3 hsa-miR-4498 -1.5 -1.54 N/A UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, B3GALT5 ENST00000380620.4 5 9 2 5 2 3 hsa-miR-5001-5p -1.48 -1.48 N/A polypeptide 5 C19orf54 ENST00000470681.1 chromosome 19 open reading frame 54 18 4 1 3 0 3 hsa-miR-4498 -1.47 -1.5 N/A

C17orf103 ENST00000468196.1 chromosome 17 open reading frame 103 54 7 4 1 2 1 hsa-miR-5001-5p -1.47 -1.47 N/A

PRAF2 ENST00000376390.4 PRA1 domain family, member 2 1921 4 1 3 0 0 hsa-miR-4498 -1.45 -1.45 N/A

C10orf91 ENST00000392630.3 chromosome 10 open reading frame 91 5 6 0 6 0 3 hsa-miR-4498 -1.43 -1.43 N/A

HES6 ENST00000409574.1 hairy and enhancer of split 6 (Drosophila) 3170 5 1 3 1 3 hsa-miR-5001-5p -1.39 -1.4 N/A

TNS4 ENST00000254051.6 tensin 4 40 4 2 2 0 4 hsa-miR-5001-5p -1.38 -1.94 N/A Uncharacterized protein; WD repeat domain AF196779.12 ENST00000376358.3 1921 4 1 3 0 0 hsa-miR-4498 -1.37 -1.37 N/A phosphoinositide-interacting protein 4 WDR45 ENST00000553851.1 WD repeat domain 45 1921 4 1 3 0 0 hsa-miR-4498 -1.37 -1.37 N/A

MEN1 ENST00000377316.2 multiple endocrine neoplasia I 8 4 2 2 0 1 hsa-miR-4498 -1.34 -1.34 N/A

GLTPD1 ENST00000343938.4 glycolipid transfer protein domain containing 1 4136 4 3 0 1 0 hsa-miR-5001-5p -1.33 -1.33 N/A NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4- NDUFA4L2 ENST00000556732.1 10 4 2 2 0 0 hsa-miR-5001-5p -1.3 -1.44 N/A like 2 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CPLX2 ENST00000359546.4 complexin 2 5 7 1 5 1 2 hsa-miR-4498 -1.29 -1.29 N/A

AC174470.1 ENST00000457257.1 164 5 2 2 1 2 hsa-miR-5001-5p -1.27 -1.27 N/A

PML ENST00000565898.1 promyelocytic leukemia 83 6* 0 3 2 3 hsa-miR-4498 -1.24 -1.24 N/A

TTLL6 ENST00000433608.2 tubulin tyrosine ligase-like family, member 6 5 2 2 0 0 1 hsa-miR-5001-5p -1.24 -1.24 N/A

CABP7 ENST00000216144.3 calcium binding protein 7 12 7 3 2 2 4 hsa-miR-5001-5p -1.23 -1.23 N/A

RP11-706O15.1 ENST00000425492.2 HCG1981372, isoform CRA_c; Uncharacterized protein 142 2 1 1 0 0 hsa-miR-4498 -1.23 -1.23 N/A

PAPLN ENST00000381166.3 papilin, proteoglycan-like sulfated glycoprotein 78 3 1 1 1 1 hsa-miR-5001-5p -1.22 -1.38 N/A

ZNF618 ENST00000288466.7 zinc finger protein 618 778 6 0 4 2 2 hsa-miR-4498 -1.2 -1.22 N/A

PRKACA ENST00000308677.4 protein kinase, cAMP-dependent, catalytic, alpha 12 3 1 2 0 2 hsa-miR-4498 -1.18 -1.18 N/A

PACS1 ENST00000320580.4 phosphofurin acidic cluster sorting protein 1 87 7 1 5 1 5 hsa-miR-4498 -1.17 -1.42 N/A

MARVELD1 ENST00000285605.6 MARVEL domain containing 1 2470 4 2 2 0 0 hsa-miR-5001-5p -1.17 -1.17 N/A

RAB5A ENST00000273047.4 RAB5A, member RAS oncogene family 68 2 2 0 0 0 hsa-miR-5001-5p -1.17 -1.17 N/A

TMEM234 ENST00000373593.1 transmembrane protein 234 51 4 1 3 0 0 hsa-miR-5001-5p -1.15 -1.15 N/A

NPTXR ENST00000333039.2 neuronal pentraxin receptor 578 5 1 4 0 3 hsa-miR-4498 -1.13 -1.13 N/A

PEX14 ENST00000356607.4 peroxisomal biogenesis factor 14 1637 7 0 7 0 0 hsa-miR-4498 -1.13 -1.13 N/A

KIF1A ENST00000320389.7 kinesin family member 1A 115 3 1 1 1 1 hsa-miR-5001-5p -1.13 -1.21 N/A

COL20A1 ENST00000422202.1 collagen, type XX, alpha 1 5 4 1 2 1 7 hsa-miR-4498 -1.12 -1.12 N/A

BCL2L13 ENST00000418951.2 BCL2-like 13 (apoptosis facilitator) 741 4 0 4 0 3 hsa-miR-4498 -1.1 -1.11 N/A

FOXK1 ENST00000328914.4 forkhead box K1 368 7* 2 3 1 5 hsa-miR-5001-5p -1.1 -1.22 N/A

CHCHD5 ENST00000409719.1 coiled-coil-helix-coiled-coil-helix domain containing 5 1577 4 1 2 1 1 hsa-miR-4498 -1.1 -1.1 N/A

ALX4 ENST00000329255.3 ALX homeobox 4 52 5 2 3 0 0 hsa-miR-4498 -1.09 -1.09 N/A

ARNT2 ENST00000303329.4 aryl-hydrocarbon receptor nuclear translocator 2 39 6 1 2 3 2 hsa-miR-4498 -1.09 -1.09 N/A

FAM222B ENST00000582266.1 family with sequence similarity 222, member B 100 5 0 2 3 4 hsa-miR-5001-5p -1.08 -1.09 N/A

RPL14 ENST00000416518.1 ribosomal protein L14 8294 3 2 0 1 0 hsa-miR-5001-5p -1.08 -1.25 N/A

TRIM66 ENST00000299550.6 tripartite motif containing 66 33 4 0 1 3 6 hsa-miR-5001-5p -1.08 -1.45 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CCL19 ENST00000378800.3 chemokine (C-C motif) ligand 19 5 1 1 0 0 0 hsa-miR-5001-5p -1.07 -1.07 N/A

TRIM62 ENST00000291416.5 tripartite motif containing 62 28 2 2 0 0 2 hsa-miR-5001-5p -1.07 -1.07 N/A

PTPRF ENST00000372414.3 protein tyrosine phosphatase, receptor type, F 14842 4 0 2 2 1 hsa-miR-5001-5p -1.07 -1.07 N/A

KRTAP10-9 ENST00000397911.3 keratin associated protein 10-9 5 2 1 1 0 1 hsa-miR-4498 -1.05 -1.05 N/A

SYNDIG1L ENST00000331628.3 synapse differentiation inducing 1-like 7 5 1 3 1 0 hsa-miR-4498 -1.05 -1.05 N/A

BBC3 ENST00000341983.4 BCL2 binding component 3 87 4 1 3 0 0 hsa-miR-4498 -1.04 -1.04 N/A

KCNIP3 ENST00000295225.5 Kv channel interacting protein 3, calsenilin 555 6 2 3 1 1 hsa-miR-5001-5p -1.04 -1.04 N/A

PTTG1IP ENST00000397887.3 pituitary tumor-transforming 1 interacting protein 1170 3 1 2 0 1 hsa-miR-5001-5p -1.04 -1.07 N/A

PVRL1 ENST00000264025.3 poliovirus receptor-related 1 (herpesvirus entry mediator C) 50 7 2 4 1 0 hsa-miR-4498 -1.03 -1.13 N/A

ALPK3 ENST00000258888.5 alpha-kinase 3 16 3 3 0 0 0 hsa-miR-5001-5p -1.03 -1.03 N/A

RAB35 ENST00000534951.1 RAB35, member RAS oncogene family 1051 6 2 4 0 1 hsa-miR-4498 -1.02 -1.09 N/A

RBBP8NL ENST00000252998.1 RBBP8 N-terminal like 5 2 1 0 1 2 hsa-miR-5001-5p -1.02 -1.02 N/A

TJAP1 ENST00000372444.2 tight junction associated protein 1 (peripheral) 15 2 1 0 1 0 hsa-miR-5001-5p -1.02 -1.02 N/A

TTBK1 ENST00000259750.4 tau tubulin kinase 1 7 5 1 4 0 0 hsa-miR-4498 -1.01 -1.01 N/A

CX3CL1 ENST00000006053.6 chemokine (C-X3-C motif) ligand 1 218 5 0 5 0 1 hsa-miR-4498 -1.01 -1.04 N/A

EEFSEC ENST00000483457.1 eukaryotic elongation factor, selenocysteine-tRNA-specific 625 4 3 1 0 3 hsa-miR-4498 -0.99 -1.22 N/A

CLEC16A ENST00000409790.1 C-type lectin domain family 16, member A 108 4 2 1 1 4 hsa-miR-5001-5p -0.98 -1.17 N/A

NF2 ENST00000347330.5 neurofibromin 2 (merlin) 828 6 0 4 2 0 hsa-miR-4498 -0.98 -1.16 N/A

NFIC ENST00000346156.5 nuclear factor I/C (CCAAT-binding transcription factor) 26 9 0 8 1 6 hsa-miR-4498 -0.98 -1.27 N/A

MUC5B ENST00000447027.1 mucin 5B, oligomeric mucus/gel-forming 5 1 1 0 0 0 hsa-miR-5001-5p -0.98 -0.98 N/A

ZNF346 ENST00000503039.1 zinc finger protein 346 5 3 2 1 0 1 hsa-miR-5001-5p -0.98 -0.98 N/A

SLC46A1 ENST00000440501.1 solute carrier family 46 (folate transporter), member 1 580 4 2 0 2 4 hsa-miR-5001-5p -0.98 -1 N/A

FBXL16 ENST00000397621.1 F-box and leucine-rich repeat protein 16 5 4 0 3 1 1 hsa-miR-5001-5p -0.98 -0.98 N/A

C2orf71 ENST00000331664.5 chromosome 2 open reading frame 71 5 2 1 0 1 1 hsa-miR-5001-5p -0.98 -0.98 N/A

ARL2BP ENST00000219204.3 ADP-ribosylation factor-like 2 binding protein 450 2 2 0 0 0 hsa-miR-5001-5p -0.98 -1 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZMIZ2 ENST00000309315.4 zinc finger, MIZ-type containing 2 761 6 1 3 2 5 hsa-miR-4498 -0.97 -1.24 N/A

CRTC1 ENST00000338797.6 CREB regulated transcription coactivator 1 322 6 2 4 0 1 hsa-miR-5001-5p -0.97 -0.99 N/A

RAB37 ENST00000392610.1 RAB37, member RAS oncogene family 875 4 3 1 0 1 hsa-miR-5001-5p -0.97 -0.97 N/A

TAGLN ENST00000532870.1 transgelin 225 2 1 0 1 1 hsa-miR-4498 -0.97 -0.99 N/A

RUFY4 ENST00000441828.2 RUN and FYVE domain containing 4 5 4 1 3 0 1 hsa-miR-4498 -0.96 -0.96 N/A

LMX1B ENST00000355497.5 LIM homeobox transcription factor 1, beta 8 5 1 3 1 1 hsa-miR-4498 -0.96 -0.96 N/A Transcription factor SOX-7; Uncharacterized protein; cDNA SOX7 ENST00000554914.1 47 4 0 2 2 2 hsa-miR-4498 -0.95 -0.98 N/A FLJ58508, highly similar to Transcription factor SOX-7 MS4A10 ENST00000308287.1 membrane-spanning 4-domains, subfamily A, member 10 5 2 2 0 0 1 hsa-miR-5001-5p -0.95 -0.95 N/A

CNIH2 ENST00000528852.1 cornichon family AMPA receptor auxiliary protein 2 158 4 0 2 2 2 hsa-miR-5001-5p -0.95 -0.95 N/A

FBXO31 ENST00000311635.7 F-box protein 31 48 4 2 1 1 1 hsa-miR-4498 -0.95 -1.07 N/A

PDK2 ENST00000503176.1 pyruvate dehydrogenase kinase, isozyme 2 681 4 1 3 0 1 hsa-miR-4498 -0.94 -1.08 N/A

OSCAR ENST00000391761.1 osteoclast associated, immunoglobulin-like receptor 5 3 0 3 0 2 hsa-miR-4498 -0.94 -0.94 N/A potassium voltage-gated channel, delayed-rectifier, KCNS1 ENST00000306117.1 5 6 0 5 1 0 hsa-miR-4498 -0.94 -0.94 N/A subfamily S, member 1 APOC2 ENST00000585786.1 apolipoprotein C-II 2242 4 0 4 0 1 hsa-miR-4498 -0.94 -0.94 N/A

TNFAIP8L2 ENST00000368910.3 tumor necrosis factor, alpha-induced protein 8-like 2 5 3 1 1 1 0 hsa-miR-5001-5p -0.93 -0.93 N/A

SIX5 ENST00000560168.1 SIX homeobox 5 47 5 0 5 0 5 hsa-miR-4498 -0.93 -0.97 N/A

ZFR2 ENST00000262961.4 zinc finger RNA binding protein 2 5 3 2 1 0 0 hsa-miR-4498 -0.93 -0.93 N/A

BSN ENST00000296452.4 bassoon presynaptic cytomatrix protein 31 3 0 2 1 4 hsa-miR-4498 -0.93 -0.93 N/A

NAA60 ENST00000610180.1 N-alpha-acetyltransferase 60 1339 2 2 0 0 2 hsa-miR-5001-5p -0.93 -0.93 N/A

ALX3 ENST00000369792.4 ALX homeobox 3 5 2 2 0 0 2 hsa-miR-5001-5p -0.92 -0.92 N/A

SAMD11 ENST00000342066.3 sterile alpha motif domain containing 11 288 3 2 0 1 0 hsa-miR-5001-5p -0.92 -0.92 N/A

JMJD8 ENST00000412368.2 jumonji domain containing 8 164 2 2 0 0 0 hsa-miR-5001-5p -0.91 -0.92 N/A

LRRC3 ENST00000291592.4 leucine rich repeat containing 3 176 6 1 2 3 5 hsa-miR-5001-5p -0.91 -1.31 N/A

KIAA1614 ENST00000367588.4 KIAA1614 5 3 2 1 0 2 hsa-miR-5001-5p -0.91 -0.91 N/A

PAX7 ENST00000420770.2 paired box 7 7 6 2 4 0 2 hsa-miR-4498 -0.91 -0.91 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PLA2G2F ENST00000375102.3 phospholipase A2, group IIF 5 4 1 3 0 0 hsa-miR-5001-5p -0.91 -0.91 N/A

CYB5R3 ENST00000361740.4 cytochrome b5 reductase 3 542 4 1 1 2 1 hsa-miR-5001-5p -0.9 -0.92 N/A

FBXO41 ENST00000295133.5 F-box protein 41 175 10 1 9 0 4 hsa-miR-4498 -0.9 -0.98 N/A

LY6E ENST00000517503.1 lymphocyte antigen 6 complex, locus E 342 3 1 2 0 0 hsa-miR-4498 -0.9 -0.9 N/A

XIRP1 ENST00000396251.1 xin actin-binding repeat containing 1 5 4 1 1 2 1 hsa-miR-5001-5p -0.9 -0.9 N/A solute carrier family 2 (facilitated glucose transporter), SLC2A8 ENST00000373360.3 324 3 1 1 1 1 hsa-miR-5001-5p -0.9 -0.9 N/A member 8 ROMO1 ENST00000374072.1 reactive oxygen species modulator 1 1945 2 1 1 0 0 hsa-miR-5001-5p -0.89 -1.17 N/A

REXO1 ENST00000170168.4 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 282 3 1 1 1 1 hsa-miR-4498 -0.89 -0.89 N/A solute carrier family 2 (facilitated glucose transporter), SLC2A6 ENST00000371897.4 172 3 2 0 1 1 hsa-miR-5001-5p -0.89 -0.89 N/A member 6 PPM1M ENST00000296487.4 protein phosphatase, Mg2+/Mn2+ dependent, 1M 5 4 1 2 1 1 hsa-miR-5001-5p -0.89 -0.89 N/A

ARHGAP1 ENST00000311956.4 Rho GTPase activating protein 1 2229 5 1 4 0 1 hsa-miR-4498 -0.89 -0.89 N/A

NMNAT2 ENST00000294868.4 nicotinamide nucleotide adenylyltransferase 2 18 2 1 0 1 1 hsa-miR-4498 -0.88 -0.88 N/A

FAM219A ENST00000379089.1 family with sequence similarity 219, member A 13 4 2 1 1 0 hsa-miR-5001-5p -0.88 -0.88 N/A

ADM2 ENST00000395738.2 adrenomedullin 2 129 4 0 2 2 2 hsa-miR-5001-5p -0.88 -0.91 N/A

PCDHGA11 ENST00000398587.2 protocadherin gamma subfamily A, 11 145 4 1 1 2 0 hsa-miR-5001-5p -0.88 -0.88 N/A

CTD-2207O23.12 ENST00000599312.1 Uncharacterized protein 32 7 2 5 0 2 hsa-miR-4498 -0.88 -2.21 N/A guanine nucleotide binding protein (G protein), alpha GNAI2 ENST00000313601.6 27 3 1 2 0 0 hsa-miR-4498 -0.87 -0.9 N/A inhibiting activity polypeptide 2 potassium inwardly-rectifying channel, subfamily J, member KCNJ5 ENST00000529694.1 12 4 1 2 1 2 hsa-miR-5001-5p -0.87 -0.96 N/A 5 PFDN1 ENST00000510217.1 prefoldin subunit 1 98 2 1 1 0 0 hsa-miR-5001-5p -0.87 -0.88 N/A

PBXIP1 ENST00000368465.1 pre-B-cell leukemia homeobox interacting protein 1 1080 2 1 1 0 0 hsa-miR-5001-5p -0.86 -0.87 N/A

RBM33 ENST00000341148.3 RNA binding motif protein 33 444 2 0 1 1 3 hsa-miR-4498 -0.86 -0.86 N/A

NANOS2 ENST00000341294.2 nanos homolog 2 (Drosophila) 5 4 0 3 1 1 hsa-miR-4498 -0.86 -0.86 N/A

C10orf71 ENST00000323868.4 chromosome 10 open reading frame 71 5 2 1 1 0 0 hsa-miR-5001-5p -0.86 -0.86 N/A

KRTAP10-2 ENST00000391621.1 keratin associated protein 10-2 5 2 1 1 0 1 hsa-miR-4498 -0.86 -0.86 N/A

CBX6 ENST00000407418.3 chromobox homolog 6 215 6 0 4 2 3 hsa-miR-4498 -0.85 -0.85 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RBPMS ENST00000320203.4 RNA binding protein with multiple splicing 472 4 2 2 0 1 hsa-miR-4498 -0.85 -0.9 N/A

KIAA0930 ENST00000336156.5 KIAA0930 1107 6 1 3 2 2 hsa-miR-5001-5p -0.85 -1.33 N/A

RELA ENST00000525693.1 v-rel avian reticuloendotheliosis viral oncogene homolog A 1707 4 0 4 0 1 hsa-miR-4498 -0.85 -0.86 N/A

MLXIP ENST00000319080.7 MLX interacting protein 69 5 0 3 2 6 hsa-miR-4498 -0.84 -1.13 N/A

TXN2 ENST00000216185.2 thioredoxin 2 3060 3 1 2 0 1 hsa-miR-4498 -0.84 -0.84 N/A

NKG7 ENST00000595217.1 natural killer cell group 7 sequence 5 2 0 2 0 0 hsa-miR-4498 -0.84 -0.84 N/A

LY6G5C ENST00000375860.2 lymphocyte antigen 6 complex, locus G5C 20 2 0 2 0 0 hsa-miR-4498 -0.84 -0.84 N/A

PCDHGA1 ENST00000517417.1 protocadherin gamma subfamily A, 1 145 4 1 1 2 0 hsa-miR-5001-5p -0.84 -0.84 N/A

PCDHGA5 ENST00000518069.1 protocadherin gamma subfamily A, 5 145 4 1 1 2 0 hsa-miR-5001-5p -0.84 -0.84 N/A

PCDHGA9 ENST00000573521.1 protocadherin gamma subfamily A, 9 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA12 ENST00000252085.3 protocadherin gamma subfamily A, 12 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA3 ENST00000253812.6 protocadherin gamma subfamily A, 3 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA6 ENST00000517434.1 protocadherin gamma subfamily A, 6 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA8 ENST00000398604.2 protocadherin gamma subfamily A, 8 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA2 ENST00000394576.2 protocadherin gamma subfamily A, 2 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA7 ENST00000518325.1 protocadherin gamma subfamily A, 7 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PCDHGA10 ENST00000398610.2 protocadherin gamma subfamily A, 10 145 4 1 1 2 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PTP4A3 ENST00000520105.1 protein tyrosine phosphatase type IVA, member 3 65 4 1 2 1 1 hsa-miR-4498 -0.83 -0.85 N/A

VTN ENST00000226218.4 vitronectin 9062 1 1 0 0 0 hsa-miR-5001-5p -0.83 -0.83 N/A

PPP1R16B ENST00000299824.1 protein phosphatase 1, regulatory subunit 16B 16 5 2 3 0 2 hsa-miR-4498 -0.83 -0.83 N/A

C14orf180 ENST00000557649.1 chromosome 14 open reading frame 180 5 3 1 2 0 2 hsa-miR-4498 -0.82 -0.82 N/A

ZFP41 ENST00000520584.1 ZFP41 zinc finger protein 7 4 1 1 2 0 hsa-miR-5001-5p -0.82 -0.82 N/A

TOX2 ENST00000372999.1 TOX high mobility group box family member 2 21 4 2 1 1 0 hsa-miR-5001-5p -0.82 -0.82 N/A

NAT8L ENST00000331662.3 N-acetyltransferase 8-like (GCN5-related, putative) 220 4 1 2 1 2 hsa-miR-5001-5p -0.81 -0.82 N/A

NFIX ENST00000360105.4 nuclear factor I/X (CCAAT-binding transcription factor) 24 10 1 8 1 3 hsa-miR-4498 -0.81 -1.03 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score potassium voltage-gated channel, Shaw-related subfamily, KCNC1 ENST00000379472.3 42 7 0 4 3 3 hsa-miR-5001-5p -0.81 -0.81 N/A member 1 nuclear factor of activated T-cells, cytoplasmic, calcineurin- NFATC2 ENST00000371564.3 105 3 0 2 1 3 hsa-miR-4498 -0.8 -0.81 N/A dependent 2 PAX5 ENST00000358127.4 paired box 5 5 3 1 2 0 7 hsa-miR-4498 -0.8 -0.8 N/A

AGRN ENST00000379370.2 agrin 11 3 1 2 0 1 hsa-miR-4498 -0.8 -0.8 N/A

PARVG ENST00000444313.3 parvin, gamma 5 4 1 2 1 3 hsa-miR-5001-5p -0.8 -0.8 N/A

DBF4B ENST00000315005.3 DBF4 homolog B (S. cerevisiae) 34 3 1 2 0 1 hsa-miR-4498 -0.8 -0.8 N/A

C11orf21 ENST00000381153.3 chromosome 11 open reading frame 21 5 4 1 0 3 1 hsa-miR-5001-5p -0.79 -0.79 N/A

FAM83G ENST00000388995.6 family with sequence similarity 83, member G 322 2 2 0 0 4 hsa-miR-5001-5p -0.79 -0.8 N/A

HSPG2 ENST00000374695.3 heparan sulfate proteoglycan 2 616 2 0 2 0 1 hsa-miR-4498 -0.79 -0.82 N/A

PKM ENST00000319622.6 pyruvate kinase, muscle 65 3 1 1 1 0 hsa-miR-5001-5p -0.79 -0.83 N/A

DFNB31 ENST00000265134.6 deafness, autosomal recessive 31 35 3 2 1 0 0 hsa-miR-5001-5p -0.79 -0.79 N/A

LDB3 ENST00000542786.1 LIM domain binding 3 33 3 0 1 2 1 hsa-miR-5001-5p -0.79 -0.79 N/A

VAMP1 ENST00000361716.3 vesicle-associated membrane protein 1 (synaptobrevin 1) 8 3 1 2 0 0 hsa-miR-4498 -0.78 -0.78 N/A

FLJ45079 ENST00000374983.2 5 4 1 2 1 0 hsa-miR-4498 -0.78 -0.78 N/A

ARHGDIA ENST00000269321.7 Rho GDP dissociation inhibitor (GDI) alpha 452 4 1 3 0 1 hsa-miR-4498 -0.78 -1.02 N/A

CEP85 ENST00000252992.4 centrosomal protein 85kDa 471 3 0 3 0 1 hsa-miR-4498 -0.78 -0.78 N/A

PKIG ENST00000372894.3 protein kinase (cAMP-dependent, catalytic) inhibitor gamma 1619 2 1 0 1 0 hsa-miR-5001-5p -0.78 -0.78 N/A

PYDC1 ENST00000302964.3 PYD (pyrin domain) containing 1 5 2 0 2 0 0 hsa-miR-5001-5p -0.78 -0.78 N/A

PMM2 ENST00000268261.4 phosphomannomutase 2 65 3 2 1 0 0 hsa-miR-4498 -0.77 -0.94 N/A

CLCF1 ENST00000312438.7 cardiotrophin-like cytokine factor 1 98 3 0 3 0 1 hsa-miR-4498 -0.77 -0.77 N/A

HCFC1 ENST00000310441.7 host cell factor C1 (VP16-accessory protein) 181 2 1 1 0 0 hsa-miR-4498 -0.77 -0.77 N/A

SPRN ENST00000414069.2 shadow of prion protein homolog (zebrafish) 5 4* 0 2 1 2 hsa-miR-4498 -0.77 -0.77 N/A

EPN2 ENST00000314728.5 epsin 2 1609 2 0 2 0 3 hsa-miR-4498 -0.77 -0.82 N/A

FOSL1 ENST00000532401.1 FOS-like antigen 1 276 4 0 2 2 0 hsa-miR-4498 -0.77 -0.78 N/A

C21orf90 ENST00000354333.5 chromosome 21 open reading frame 90 26 5 3 2 0 1 hsa-miR-4498 -0.77 -2.11 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CBX7 ENST00000216133.5 chromobox homolog 7 5 4 3 1 0 5 hsa-miR-5001-5p -0.77 -0.77 N/A

TAOK2 ENST00000308893.4 TAO kinase 2 136 2 1 1 0 0 hsa-miR-4498 -0.76 -0.76 N/A solute carrier family 7 (amino acid transporter light chain, L SLC7A8 ENST00000469263.1 15 4 0 3 1 1 hsa-miR-4498 -0.76 -0.76 N/A system), member 8 XXYLT1 ENST00000310380.6 xyloside xylosyltransferase 1 1052 3 2 1 0 0 hsa-miR-5001-5p -0.76 -0.97 N/A

DPYSL5 ENST00000288699.6 dihydropyrimidinase-like 5 315 4 0 4 0 6 hsa-miR-5001-5p -0.76 -0.9 N/A

SYT2 ENST00000367267.1 synaptotagmin II 5 5 0 3 2 3 hsa-miR-5001-5p -0.76 -0.76 N/A

PAQR4 ENST00000318782.8 progestin and adipoQ receptor family member IV 703 3 1 2 0 0 hsa-miR-4498 -0.76 -0.77 N/A

DAP ENST00000230895.6 death-associated protein 8552 4 1 0 3 0 hsa-miR-5001-5p -0.76 -0.95 N/A

PLCD3 ENST00000322765.5 phospholipase C, delta 3 84 4 1 1 2 0 hsa-miR-4498 -0.76 -0.76 N/A CDNA: FLJ23120 fis, clone LNG07989; HCG1987724; AC138655.1 ENST00000601243.1 5 2 1 1 0 1 hsa-miR-4498 -0.76 -0.76 N/A Uncharacterized protein MICB ENST00000399150.3 MHC class I polypeptide-related sequence B 189 2 2 0 0 0 hsa-miR-5001-5p -0.76 -0.77 N/A

CINP ENST00000541568.2 cyclin-dependent kinase 2 interacting protein 2407 3 0 3 0 0 hsa-miR-5001-5p -0.76 -0.76 N/A

NRSN2 ENST00000382291.3 neurensin 2 101 3 1 2 0 0 hsa-miR-4498 -0.76 -0.76 N/A

NCKAP5L ENST00000335999.6 NCK-associated protein 5-like 141 4 0 4 0 1 hsa-miR-4498 -0.75 -0.75 N/A

ARHGEF39 ENST00000343259.3 Rho guanine nucleotide exchange factor (GEF) 39 141 2 1 1 0 2 hsa-miR-5001-5p -0.75 -0.83 N/A

PSD4 ENST00000441564.3 pleckstrin and Sec7 domain containing 4 72 5 1 1 3 2 hsa-miR-5001-5p -0.75 -1.51 N/A

ABHD14B ENST00000461108.1 abhydrolase domain containing 14B 189 4 1 3 0 0 hsa-miR-4498 -0.75 -0.78 N/A

KDM6B ENST00000254846.5 lysine (K)-specific demethylase 6B 8 3 0 3 0 1 hsa-miR-5001-5p -0.75 -0.75 N/A

ZNF672 ENST00000306562.3 zinc finger protein 672 189 2 1 1 0 1 hsa-miR-5001-5p -0.75 -0.75 N/A

TM9SF4 ENST00000398022.2 transmembrane 9 superfamily protein member 4 3096 3 0 3 0 0 hsa-miR-4498 -0.75 -0.82 N/A

TRAM2 ENST00000182527.3 translocation associated membrane protein 2 2774 5 1 3 1 3 hsa-miR-4498 -0.74 -0.75 N/A

RAB43 ENST00000476465.1 RAB43, member RAS oncogene family 5 4 0 3 1 3 hsa-miR-4498 -0.74 -1.04 N/A

AGER ENST00000375065.5 advanced glycosylation end product-specific receptor 7 2 0 2 0 0 hsa-miR-4498 -0.74 -0.74 N/A

ISY1-RAB43 ENST00000418265.1 ISY1-RAB43 readthrough 5 4 0 3 1 3 hsa-miR-5001-5p -0.74 -0.74 N/A

CD7 ENST00000584284.1 CD7 molecule 317 4 2 1 1 1 hsa-miR-5001-5p -0.74 -0.74 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score LYNX1 ENST00000395192.2 Ly6/neurotoxin 1 5 5 0 4 1 4 hsa-miR-5001-5p -0.74 -0.74 N/A

GPRIN1 ENST00000303991.4 G protein regulated inducer of neurite outgrowth 1 15 4 0 4 0 1 hsa-miR-4498 -0.74 -0.74 N/A

SPOCD1 ENST00000373648.2 SPOC domain containing 1 755 4 0 3 1 2 hsa-miR-4498 -0.73 -0.73 N/A

SNX19 ENST00000265909.4 sorting nexin 19 1157 2 1 1 0 0 hsa-miR-4498 -0.73 -0.74 N/A

SPTBN2 ENST00000529997.1 spectrin, beta, non-erythrocytic 2 910 3 0 0 3 4 hsa-miR-5001-5p -0.73 -0.95 N/A

ZC3H7B ENST00000352645.4 zinc finger CCCH-type containing 7B 888 4 1 3 0 3 hsa-miR-4498 -0.73 -0.73 N/A

EPHA8 ENST00000166244.3 EPH receptor A8 5 4 1 3 0 1 hsa-miR-4498 -0.73 -0.73 N/A

ERI3 ENST00000372259.5 ERI1 exoribonuclease family member 3 540 2 1 0 1 1 hsa-miR-5001-5p -0.73 -0.73 N/A

ZDHHC22 ENST00000319374.4 zinc finger, DHHC-type containing 22 32 3 1 2 0 1 hsa-miR-4498 -0.73 -0.73 N/A

IGDCC4 ENST00000352385.2 immunoglobulin superfamily, DCC subclass, member 4 12 3 1 1 1 1 hsa-miR-4498 -0.73 -0.73 N/A

hsa-mir-1199 ENST00000587086.1 hsa-mir-1199 45 2 0 2 0 0 hsa-miR-4498 -0.73 -0.73 N/A

GRIK3 ENST00000373091.3 glutamate receptor, ionotropic, kainate 3 7 5 1 3 1 3 hsa-miR-5001-5p -0.73 -0.73 N/A

HLA-DOB ENST00000438763.2 major histocompatibility complex, class II, DO beta 5 2 0 2 0 0 hsa-miR-4498 -0.73 -0.73 N/A

AOC3 ENST00000591562.1 amine oxidase, copper containing 3 59 3 0 3 0 0 hsa-miR-5001-5p -0.73 -0.73 N/A

ACE ENST00000290866.4 angiotensin I converting enzyme 12 3 2 1 0 2 hsa-miR-5001-5p -0.72 -1.18 N/A CDNA FLJ25492 fis, clone CBR01389; Uncharacterized Z98049.1 ENST00000598601.1 5 3 1 1 1 0 hsa-miR-4498 -0.72 -0.72 N/A protein PRKACG ENST00000377276.2 protein kinase, cAMP-dependent, catalytic, gamma 5 2 0 2 0 0 hsa-miR-4498 -0.72 -0.72 N/A

WARS ENST00000392882.2 tryptophanyl-tRNA synthetase 1916 2 1 0 1 2 hsa-miR-5001-5p -0.72 -0.73 N/A

CTD-2368P22.1 ENST00000550135.1 HCG1811579; Uncharacterized protein 25 4 2 1 1 0 hsa-miR-5001-5p -0.72 -0.72 N/A

MUC6 ENST00000421673.2 mucin 6, oligomeric mucus/gel-forming 5 3 0 3 0 0 hsa-miR-4498 -0.72 -0.72 N/A

CSF3R ENST00000373106.1 colony stimulating factor 3 receptor (granulocyte) 49 2 1 1 0 0 hsa-miR-5001-5p -0.72 -0.72 N/A

SUV39H1 ENST00000453214.2 suppressor of variegation 3-9 homolog 1 (Drosophila) 499 4 0 4 0 0 hsa-miR-4498 -0.72 -0.72 N/A

RELT ENST00000064780.2 RELT tumor necrosis factor receptor 412 4 0 4 0 0 hsa-miR-4498 -0.72 -0.99 N/A

WFDC2 ENST00000372676.3 WAP four-disulfide core domain 2 27 1 1 0 0 0 hsa-miR-5001-5p -0.71 -0.71 N/A

SEPT6 ENST00000394610.1 septin 6 1854 3 0 3 0 0 hsa-miR-4498 -0.71 -0.75 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PANX2 ENST00000159647.5 pannexin 2 169 4 2 1 1 0 hsa-miR-5001-5p -0.71 -0.71 N/A

ENTPD2 ENST00000355097.2 ectonucleoside triphosphate diphosphohydrolase 2 8 4 1 1 2 1 hsa-miR-5001-5p -0.71 -0.71 N/A semaphorin 7A, GPI membrane anchor (John Milton Hagen SEMA7A ENST00000261918.4 65 4 1 2 1 1 hsa-miR-5001-5p -0.71 -0.78 N/A blood group) 1-aminocyclopropane-1-carboxylate synthase homolog ACCSL ENST00000378832.1 5 1 1 0 0 0 hsa-miR-5001-5p -0.71 -0.71 N/A (Arabidopsis)(non-functional)-like ATP6V0E2 ENST00000425642.2 ATPase, H+ transporting V0 subunit e2 85 4 0 3 1 0 hsa-miR-4498 -0.71 -0.71 N/A

PKP2 ENST00000340811.4 plakophilin 2 265 2 2 0 0 0 hsa-miR-5001-5p -0.71 -0.71 N/A

GATS ENST00000436886.2 GATS, stromal antigen 3 opposite strand 86 3 0 3 0 1 hsa-miR-4498 -0.71 -0.71 N/A

GAS8 ENST00000268699.4 growth arrest-specific 8 526 4 1 0 3 1 hsa-miR-5001-5p -0.71 -0.75 N/A

ZCCHC24 ENST00000372336.3 zinc finger, CCHC domain containing 24 359 4 0 4 0 4 hsa-miR-4498 -0.71 -0.77 N/A

AC008132.13 ENST00000342005.4 Uncharacterized protein 5 2 1 0 1 0 hsa-miR-5001-5p -0.71 -0.71 N/A XXbac- ENST00000461287.1 1251 2 1 1 0 1 hsa-miR-5001-5p -0.7 -0.7 N/A BPG32J3.20 KRT5 ENST00000252242.4 keratin 5 7 2 1 1 0 0 hsa-miR-4498 -0.7 -0.7 N/A Uncharacterized protein; cDNA FLJ45856 fis, clone AC010327.2 ENST00000598855.1 7 3 2 1 0 0 hsa-miR-5001-5p -0.7 -0.7 N/A OCBBF2025631 PYCR1 ENST00000329875.8 pyrroline-5-carboxylate reductase 1 157 2 1 1 0 1 hsa-miR-4498 -0.7 -0.71 N/A

ZFP36L1 ENST00000555997.1 ZFP36 ring finger protein-like 1 231 3 0 3 0 3 hsa-miR-4498 -0.7 -0.7 N/A

HS1BP3 ENST00000304031.3 HCLS1 binding protein 3 191 4 1 3 0 1 hsa-miR-5001-5p -0.7 -0.9 N/A

MT-ATP6 ENST00000361899.2 mitochondrially encoded ATP synthase 6 239820 1 1 0 0 1 hsa-miR-5001-5p -0.7 -0.7 N/A

TPRXL ENST00000326972.8 tetra-peptide repeat homeobox-like 5 3 0 3 0 0 hsa-miR-4498 -0.7 -0.7 N/A

PAFAH2 ENST00000374282.3 platelet-activating factor acetylhydrolase 2, 40kDa 287 2 1 0 1 0 hsa-miR-5001-5p -0.7 -0.7 N/A

NRG1 ENST00000341377.5 neuregulin 1 113 4 2 0 2 1 hsa-miR-5001-5p -0.69 -0.71 N/A

TRIM44 ENST00000299413.5 tripartite motif containing 44 4203 5 1 3 1 3 hsa-miR-4498 -0.69 -0.87 N/A

C11orf49 ENST00000395460.2 chromosome 11 open reading frame 49 1263 3 0 1 2 1 hsa-miR-5001-5p -0.69 -0.69 N/A pleckstrin homology domain containing, family B (evectins) PLEKHB1 ENST00000354190.5 529 2 1 1 0 0 hsa-miR-4498 -0.69 -0.69 N/A member 1 TMEM92 ENST00000300433.3 transmembrane protein 92 46 4 1 1 2 2 hsa-miR-5001-5p -0.69 -0.83 N/A

FMNL1 ENST00000331495.3 formin-like 1 33 2 0 2 0 1 hsa-miR-5001-5p -0.69 -0.69 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TARBP2 ENST00000552857.1 TAR (HIV-1) RNA binding protein 2 1553 1 1 0 0 1 hsa-miR-5001-5p -0.69 -0.69 N/A

SYNGR3 ENST00000562045.1 synaptogyrin 3 223 3 0 3 0 0 hsa-miR-4498 -0.69 -0.7 N/A

PAK4 ENST00000599386.1 p21 protein (Cdc42/Rac)-activated kinase 4 130 6 0 6 0 1 hsa-miR-4498 -0.69 -0.87 N/A

TRAF1 ENST00000373887.3 TNF receptor-associated factor 1 5 3 2 1 0 2 hsa-miR-5001-5p -0.69 -0.8 N/A

TRMT61A ENST00000389749.4 tRNA methyltransferase 61 homolog A (S. cerevisiae) 296 5 2 2 1 2 hsa-miR-5001-5p -0.69 -1.13 N/A

ZC3H4 ENST00000253048.5 zinc finger CCCH-type containing 4 182 1 0 0 1 4 hsa-miR-5001-5p -0.69 -0.7 N/A

HSPB6 ENST00000587965.1 heat shock protein, alpha-crystallin-related, B6 121 1 1 0 0 2 hsa-miR-4498 -0.69 -0.72 N/A

PRODH ENST00000420436.1 proline dehydrogenase (oxidase) 1 5 2 1 1 0 1 hsa-miR-4498 -0.69 -0.69 N/A

LENEP ENST00000392487.1 lens epithelial protein 5 1 1 0 0 0 hsa-miR-4498 -0.69 -0.69 N/A

OTOG ENST00000399397.1 otogelin 5 2 0 1 1 1 hsa-miR-5001-5p -0.69 -0.69 N/A

OPN4 ENST00000372071.2 opsin 4 5 3 0 3 0 1 hsa-miR-4498 -0.69 -0.69 N/A

IGLL1 ENST00000249053.3 immunoglobulin lambda-like polypeptide 1 5 2 0 2 0 0 hsa-miR-4498 -0.69 -0.69 N/A

WNK2 ENST00000395475.2 WNK lysine deficient protein kinase 2 134 9 0 9 0 4 hsa-miR-5001-5p -0.68 -0.68 N/A

PES1 ENST00000354694.7 pescadillo ribosomal biogenesis factor 1 848 3 0 3 0 2 hsa-miR-5001-5p -0.68 -0.68 N/A

AL355390.1 ENST00000325811.1 Uncharacterized protein 5 3 0 1 2 2 hsa-miR-5001-5p -0.68 -0.68 N/A

CMTM5 ENST00000359320.3 CKLF-like MARVEL transmembrane domain containing 5 5 2 0 2 0 0 hsa-miR-4498 -0.68 -0.68 N/A

TRABD ENST00000303434.4 TraB domain containing 2527 2 1 1 0 4 hsa-miR-4498 -0.68 -0.68 N/A

PRSS42 ENST00000447340.1 protease, serine, 42 5 2 1 0 1 0 hsa-miR-4498 -0.68 -0.68 N/A

TSPAN11 ENST00000261177.9 tetraspanin 11 27 5 0 3 2 1 hsa-miR-4498 -0.68 -0.68 N/A

HAAO ENST00000294973.6 3-hydroxyanthranilate 3,4-dioxygenase 7 4 1 1 2 0 hsa-miR-5001-5p -0.67 -0.95 N/A

S100A7A ENST00000368729.4 S100 calcium binding protein A7A 5 3 1 1 1 0 hsa-miR-5001-5p -0.67 -0.67 N/A

TCF7L1 ENST00000282111.3 transcription factor 7-like 1 (T-cell specific, HMG-box) 577 2 1 1 0 0 hsa-miR-5001-5p -0.67 -0.67 N/A

ARC ENST00000356613.2 activity-regulated cytoskeleton-associated protein 5 4 0 2 2 1 hsa-miR-4498 -0.67 -0.67 N/A

HAP1 ENST00000393939.2 huntingtin-associated protein 1 5 3 1 1 1 3 hsa-miR-5001-5p -0.67 -0.67 N/A

RP11-389E17.1 ENST00000507870.1 HCG2025867; Uncharacterized protein 5 1 1 0 0 0 hsa-miR-4498 -0.67 -0.67 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score BSDC1 ENST00000341071.7 BSD domain containing 1 714 2 1 0 1 2 hsa-miR-5001-5p -0.67 -0.67 N/A

NBPF8 ENST00000369190.5 neuroblastoma breakpoint family, member 8 5 2 0 2 0 0 hsa-miR-4498 -0.67 -0.67 N/A

POTEM ENST00000551509.1 POTE ankyrin domain family, member M 5 2 1 0 1 2 hsa-miR-5001-5p -0.67 -0.67 N/A

ARID3B ENST00000346246.5 AT rich interactive domain 3B (BRIGHT-like) 11 4 1 2 1 4 hsa-miR-4498 -0.67 -0.67 N/A

SBK1 ENST00000341901.4 SH3 domain binding kinase 1 9 4 0 3 1 3 hsa-miR-4498 -0.67 -0.67 N/A

STK40 ENST00000359297.2 serine/threonine kinase 40 214 9 1 3 5 3 hsa-miR-5001-5p -0.67 -0.69 N/A

POTEG ENST00000409832.3 POTE ankyrin domain family, member G 5 2 1 0 1 2 hsa-miR-5001-5p -0.67 -0.67 N/A

CEMP1 ENST00000382350.1 cementum protein 1 5 2 1 0 1 0 hsa-miR-5001-5p -0.67 -0.67 N/A

GAMT ENST00000252288.2 guanidinoacetate N-methyltransferase 12541 2 1 1 0 0 hsa-miR-4498 -0.67 -0.67 N/A glycerophosphodiester phosphodiesterase domain containing GDPD5 ENST00000443276.2 8 3 1 1 1 2 hsa-miR-4498 -0.67 -0.67 N/A 5 TUSC5 ENST00000333813.3 tumor suppressor candidate 5 5 2 1 1 0 4 hsa-miR-4498 -0.67 -0.67 N/A

RCN3 ENST00000270645.3 reticulocalbin 3, EF-hand calcium binding domain 3731 2 1 1 0 0 hsa-miR-5001-5p -0.66 -0.66 N/A solute carrier family 9, subfamily A (NHE8, cation proton SLC9A8 ENST00000361573.2 474 5 0 4 1 3 hsa-miR-5001-5p -0.66 -0.69 N/A antiporter 8), member 8 KLF16 ENST00000250916.4 Kruppel-like factor 16 5 4 0 3 1 0 hsa-miR-4498 -0.66 -0.66 N/A

OR10W1 ENST00000395079.2 olfactory receptor, family 10, subfamily W, member 1 5 1 1 0 0 0 hsa-miR-4498 -0.66 -0.66 N/A

RNF44 ENST00000274811.4 ring finger protein 44 1623 3 0 2 1 1 hsa-miR-4498 -0.66 -0.66 N/A

SND1 ENST00000354725.3 staphylococcal nuclease and tudor domain containing 1 7201 5 2 3 0 4 hsa-miR-4498 -0.65 -1.22 N/A

FAM163A ENST00000341785.4 family with sequence similarity 163, member A 23 4 1 1 2 3 hsa-miR-5001-5p -0.65 -0.69 N/A

CYP2W1 ENST00000340150.6 cytochrome P450, family 2, subfamily W, polypeptide 1 5 4 0 3 1 1 hsa-miR-4498 -0.65 -0.65 N/A

SPNS2 ENST00000329078.3 spinster homolog 2 (Drosophila) 7 4 2 2 0 1 hsa-miR-4498 -0.65 -0.7 N/A

TMEM105 ENST00000332900.1 transmembrane protein 105 5 5 0 5 0 3 hsa-miR-4498 -0.65 -0.65 N/A

SYT12 ENST00000393946.2 synaptotagmin XII 813 6 0 2 4 0 hsa-miR-5001-5p -0.65 -0.65 N/A

TSPAN33 ENST00000289407.4 tetraspanin 33 237 3 0 2 1 1 hsa-miR-4498 -0.65 -0.65 N/A

TEX40 ENST00000539943.1 testis expressed 40 8 2 0 2 0 0 hsa-miR-4498 -0.65 -0.65 N/A

CLIP3 ENST00000360535.4 CAP-GLY domain containing linker protein 3 9 3 1 2 0 1 hsa-miR-4498 -0.65 -1.02 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TFRC ENST00000540528.1 transferrin receptor 296 2 1 0 1 0 hsa-miR-5001-5p -0.65 -0.65 N/A

HOXA7 ENST00000242159.3 homeobox A7 27 2 1 1 0 1 hsa-miR-5001-5p -0.64 -0.71 N/A protein tyrosine phosphatase, receptor type, C-associated PTPRCAP ENST00000326294.3 7 1 1 0 0 0 hsa-miR-5001-5p -0.64 -0.64 N/A protein ZDHHC8 ENST00000334554.7 zinc finger, DHHC-type containing 8 5 4 0 3 1 1 hsa-miR-4498 -0.64 -0.64 N/A

AC003102.1 ENST00000399246.2 5 1 1 0 0 0 hsa-miR-5001-5p -0.64 -0.64 N/A

REEP6 ENST00000233596.3 receptor accessory protein 6 822 2 0 2 0 4 hsa-miR-4498 -0.64 -0.64 N/A

AC110781.3 ENST00000402221.1 Protein LOC100128374 5 3 1 0 2 4 hsa-miR-5001-5p -0.64 -0.64 N/A

TBC1D3F ENST00000378174.5 TBC1 domain family, member 3F 5 4 0 4 0 0 hsa-miR-4498 -0.64 -0.64 N/A

GPR39 ENST00000329321.3 G protein-coupled receptor 39 151 3 0 1 2 0 hsa-miR-5001-5p -0.64 -0.64 N/A

ZNF319 ENST00000299237.2 zinc finger protein 319 521 3 1 1 1 2 hsa-miR-4498 -0.64 -0.64 N/A

TBC1D3 ENST00000339023.4 TBC1 domain family, member 3 5 4 0 4 0 0 hsa-miR-4498 -0.64 -0.64 N/A

ADORA1 ENST00000367235.1 adenosine A1 receptor 5 2 2 0 0 1 hsa-miR-5001-5p -0.64 -0.64 N/A

RDH13 ENST00000415061.3 retinol dehydrogenase 13 (all-trans/9-cis) 35 3 0 2 1 2 hsa-miR-4498 -0.63 -0.77 N/A

KCTD10 ENST00000228495.6 potassium channel tetramerization domain containing 10 147 4 0 3 1 1 hsa-miR-4498 -0.63 -0.73 N/A

SNX21 ENST00000462307.1 sorting nexin family member 21 343 2 1 1 0 0 hsa-miR-5001-5p -0.63 -0.69 N/A CD74 molecule, major histocompatibility complex, class II CD74 ENST00000377795.3 168 2 0 2 0 1 hsa-miR-4498 -0.63 -0.63 N/A invariant chain TAB1 ENST00000216160.6 TGF-beta activated kinase 1/MAP3K7 binding protein 1 577 6 1 3 2 6 hsa-miR-5001-5p -0.63 -1.64 N/A

SZT2 ENST00000562955.1 seizure threshold 2 homolog (mouse) 123 8 0 5 3 4 hsa-miR-5001-5p -0.63 -0.89 N/A

SLX4 ENST00000294008.3 SLX4 structure-specific endonuclease subunit 48 3 0 1 2 2 hsa-miR-4498 -0.63 -0.63 N/A

PPP3R2 ENST00000374806.1 protein phosphatase 3, regulatory subunit B, beta 5 3 1 0 2 1 hsa-miR-5001-5p -0.63 -0.63 N/A

APC2 ENST00000233607.2 adenomatosis polyposis coli 2 10 5 0 5 0 1 hsa-miR-4498 -0.63 -0.63 N/A

IL1R1 ENST00000410023.1 interleukin 1 receptor, type I 1713 4 1 0 3 0 hsa-miR-5001-5p -0.63 -0.63 N/A

TMEM52 ENST00000378602.3 transmembrane protein 52 20 2 1 1 0 1 hsa-miR-4498 -0.63 -0.63 N/A

NPLOC4 ENST00000572760.1 nuclear protein localization 4 homolog (S. cerevisiae) 1360 2 1 1 0 2 hsa-miR-5001-5p -0.63 -0.67 N/A

HR ENST00000381418.4 hair growth associated 248 1 0 0 1 4 hsa-miR-5001-5p -0.63 -0.66 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SRRM3 ENST00000326382.8 serine/arginine repetitive matrix 3 16 5 0 4 1 3 hsa-miR-4498 -0.63 -0.63 N/A solute carrier family 6 (neurotransmitter transporter, SLC6A9 ENST00000372310.3 74 3 1 2 0 1 hsa-miR-4498 -0.62 -0.66 N/A glycine), member 9 C10orf67 ENST00000323327.4 chromosome 10 open reading frame 67 5 2 1 1 0 0 hsa-miR-5001-5p -0.62 -0.62 N/A

AQP2 ENST00000199280.3 aquaporin 2 (collecting duct) 5 2 1 1 0 1 hsa-miR-5001-5p -0.62 -0.62 N/A

TRAIP ENST00000331456.2 TRAF interacting protein 5 2 1 0 1 0 hsa-miR-5001-5p -0.62 -0.62 N/A

ISX ENST00000308700.6 intestine-specific homeobox 251 3 1 0 2 0 hsa-miR-5001-5p -0.62 -0.62 N/A

PRRC2B ENST00000372249.1 proline-rich coiled-coil 2B 97 3 0 2 1 0 hsa-miR-5001-5p -0.62 -0.79 N/A

KIAA0040 ENST00000423313.1 KIAA0040 15 3 0 3 0 0 hsa-miR-4498 -0.62 -0.62 N/A

EIF4EBP1 ENST00000338825.4 eukaryotic translation initiation factor 4E binding protein 1 121 4* 1 2 0 1 hsa-miR-5001-5p -0.62 -1.12 N/A

APRT ENST00000426324.2 adenine phosphoribosyltransferase 2906 1 1 0 0 0 hsa-miR-5001-5p -0.62 -0.62 N/A

PFKL ENST00000349048.4 phosphofructokinase, liver 750 3 0 2 1 0 hsa-miR-4498 -0.62 -0.62 N/A

ATG9B ENST00000605938.1 autophagy related 9B 5 5 0 3 2 3 hsa-miR-4498 -0.62 -0.62 N/A

RPL18 ENST00000549273.1 ribosomal protein L18 4686 2 1 1 0 0 hsa-miR-5001-5p -0.62 -0.62 N/A

TNFAIP1 ENST00000226225.2 tumor necrosis factor, alpha-induced protein 1 (endothelial) 1565 3 0 2 1 1 hsa-miR-4498 -0.62 -0.66 N/A

FAIM2 ENST00000320634.3 Fas apoptotic inhibitory molecule 2 5 5 1 3 1 2 hsa-miR-4498 -0.62 -0.62 N/A solute carrier family 25 (mitochondrial thiamine SLC25A19 ENST00000416858.2 108 1 1 0 0 1 hsa-miR-5001-5p -0.62 -0.62 N/A pyrophosphate carrier), member 19 C10orf105 ENST00000441508.2 chromosome 10 open reading frame 105 5 3 1 2 0 0 hsa-miR-5001-5p -0.62 -0.62 N/A

ZBTB7C ENST00000535628.2 zinc finger and BTB domain containing 7C 23 4 1 1 2 1 hsa-miR-5001-5p -0.62 -0.76 N/A

AKT1S1 ENST00000391833.1 AKT1 substrate 1 (proline-rich) 754 1 1 0 0 0 hsa-miR-5001-5p -0.62 -0.62 N/A

CRABP2 ENST00000368222.3 cellular retinoic acid binding protein 2 9 1 1 0 0 0 hsa-miR-5001-5p -0.61 -0.61 N/A

TMEM54 ENST00000373463.3 transmembrane protein 54 35 1 1 0 0 0 hsa-miR-5001-5p -0.61 -0.61 N/A

MFAP4 ENST00000497081.2 microfibrillar-associated protein 4 67 3 1 1 1 0 hsa-miR-5001-5p -0.61 -0.61 N/A

SAMD1 ENST00000533683.2 sterile alpha motif domain containing 1 12 2 1 1 0 1 hsa-miR-4498 -0.61 -0.61 N/A

MAMLD1 ENST00000370401.2 mastermind-like domain containing 1 1442 4 0 2 2 0 hsa-miR-4498 -0.61 -0.61 N/A

LIMS3L ENST00000413601.2 LIM and senescent cell antigen-like domains 3-like 5 1 1 0 0 0 hsa-miR-4498 -0.61 -0.61 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM41A ENST00000296254.3 transmembrane protein 41A 382 3 0 3 0 0 hsa-miR-4498 -0.61 -0.8 N/A

C1QL1 ENST00000253407.3 complement component 1, q subcomponent-like 1 14 2 1 1 0 0 hsa-miR-5001-5p -0.61 -0.61 N/A

PER1 ENST00000317276.4 period circadian clock 1 1210 3 1 2 0 0 hsa-miR-5001-5p -0.61 -0.65 N/A

EDAR ENST00000409271.1 ectodysplasin A receptor 7 2 2 0 0 0 hsa-miR-5001-5p -0.61 -0.61 N/A sphingomyelin phosphodiesterase 3, neutral membrane SMPD3 ENST00000219334.5 9 4 1 2 1 2 hsa-miR-4498 -0.61 -0.61 N/A (neutral sphingomyelinase II) KLK11 ENST00000600362.1 kallikrein-related peptidase 11 5 2 0 1 1 0 hsa-miR-4498 -0.61 -0.61 N/A

CYB561D1 ENST00000496961.1 cytochrome b561 family, member D1 105 3 0 2 1 1 hsa-miR-5001-5p -0.61 -0.61 N/A solute carrier family 17 (vesicular nucleotide transporter), SLC17A9 ENST00000370351.4 504 4 1 1 2 1 hsa-miR-5001-5p -0.61 -0.67 N/A member 9 GSK3A ENST00000222330.3 glycogen synthase kinase 3 alpha 322 1 1 0 0 0 hsa-miR-4498 -0.61 -0.61 N/A

TMCC3 ENST00000261226.4 transmembrane and coiled-coil domain family 3 70 3 2 0 1 0 hsa-miR-5001-5p -0.61 -0.64 N/A

IGFBP5 ENST00000233813.4 insulin-like growth factor binding protein 5 10709 4 0 3 1 1 hsa-miR-4498 -0.61 -0.85 N/A

BABAM1 ENST00000598188.1 BRISC and BRCA1 A complex member 1 419 1 1 0 0 0 hsa-miR-5001-5p -0.61 -0.61 N/A

MAPK8IP3 ENST00000250894.4 mitogen-activated protein kinase 8 interacting protein 3 100 3 1 1 1 0 hsa-miR-5001-5p -0.6 -0.6 N/A

PPY ENST00000225992.3 pancreatic polypeptide 5 1 1 0 0 0 hsa-miR-5001-5p -0.6 -0.6 N/A

RGMA ENST00000557420.1 RGM domain family, member A 145 3 0 2 1 3 hsa-miR-4498 -0.6 -0.62 N/A

SMYD1 ENST00000419482.2 SET and MYND domain containing 1 5 2 1 1 0 0 hsa-miR-4498 -0.6 -0.6 N/A pleckstrin homology domain containing, family G (with PLEKHG4B ENST00000283426.6 5 5 0 4 1 6 hsa-miR-4498 -0.6 -0.6 N/A RhoGef domain) member 4B CDC42SE1 ENST00000439374.2 CDC42 small effector 1 231 1 1 0 0 1 hsa-miR-5001-5p -0.6 -0.6 N/A

CUEDC1 ENST00000577830.1 CUE domain containing 1 1243 3 1 2 0 1 hsa-miR-4498 -0.6 -0.61 N/A

ATPIF1 ENST00000465645.1 ATPase inhibitory factor 1 15846 2 0 1 1 0 hsa-miR-4498 -0.6 -0.6 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ6 ENST00000609713.1 5 4 1 1 2 1 hsa-miR-5001-5p -0.6 -0.6 N/A 6 UBA1 ENST00000377351.4 ubiquitin-like modifier activating enzyme 1 1312 1 1 0 0 0 hsa-miR-5001-5p -0.6 -0.6 N/A optic atrophy 3 (autosomal recessive, with chorea and OPA3 ENST00000263275.4 137 3 0 2 1 4 hsa-miR-5001-5p -0.6 -1.08 N/A spastic paraplegia) PRCC ENST00000271526.4 papillary renal cell carcinoma (translocation-associated) 8562 2 1 1 0 0 hsa-miR-5001-5p -0.6 -0.6 N/A

HPCAL4 ENST00000372844.3 hippocalcin like 4 5 4 0 2 2 0 hsa-miR-4498 -0.6 -0.6 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score POU2F2 ENST00000342301.4 POU class 2 homeobox 2 5 5 1 3 1 1 hsa-miR-4498 -0.6 -0.8 N/A dolichyl-phosphate mannosyltransferase polypeptide 2, DPM2 ENST00000314392.8 1667 3 0 3 0 1 hsa-miR-4498 -0.6 -0.6 N/A regulatory subunit PUF60 ENST00000526683.1 poly-U binding splicing factor 60KDa 7802 1 1 0 0 0 hsa-miR-5001-5p -0.6 -0.6 N/A

MNT ENST00000174618.4 MNT, MAX dimerization protein 146 4 0 4 0 1 hsa-miR-4498 -0.6 -0.65 N/A LSM2 homolog, U6 small nuclear RNA associated (S. LSM2 ENST00000375661.5 8730 1 1 0 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A cerevisiae) ANPEP ENST00000300060.6 alanyl (membrane) aminopeptidase 216 2 1 1 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A

PRX ENST00000291825.7 periaxin 17 3 1 2 0 7 hsa-miR-5001-5p -0.59 -0.59 N/A HCG2032453; Uncharacterized protein; cDNA FLJ25337 AP000889.3 ENST00000600612.1 5 1 1 0 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A fis, clone TST00714 FGF17 ENST00000359441.3 fibroblast growth factor 17 5 2 0 2 0 1 hsa-miR-4498 -0.59 -0.59 N/A

PHF15 ENST00000402835.1 PHD finger protein 15 387 6 3 2 1 1 hsa-miR-4498 -0.59 -0.75 N/A

GPR20 ENST00000377741.3 G protein-coupled receptor 20 34 7 2 5 0 1 hsa-miR-5001-5p -0.59 -0.72 N/A

C16orf58 ENST00000570164.1 chromosome 16 open reading frame 58 25 2 1 1 0 1 hsa-miR-5001-5p -0.59 -0.59 N/A

C2orf57 ENST00000313965.2 chromosome 2 open reading frame 57 5 1 1 0 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A

PHF12 ENST00000577226.1 PHD finger protein 12 307 4 1 1 2 2 hsa-miR-4498 -0.59 -0.59 N/A

SDC3 ENST00000336798.7 syndecan 3 34 5 2 1 2 3 hsa-miR-4498 -0.59 -1.32 N/A

NCS1 ENST00000372398.3 neuronal calcium sensor 1 1083 8 1 4 3 8 hsa-miR-4498 -0.59 -1 N/A

KRTAP13-3 ENST00000390690.2 keratin associated protein 13-3 5 1 0 1 0 0 hsa-miR-4498 -0.59 -0.59 N/A

ALDH3A1 ENST00000395555.3 aldehyde dehydrogenase 3 family, member A1 140 1 1 0 0 1 hsa-miR-5001-5p -0.59 -0.59 N/A

SHB ENST00000377707.3 Src homology 2 domain containing adaptor protein B 1436 4 1 3 0 5 hsa-miR-5001-5p -0.59 -0.82 N/A

C2orf50 ENST00000381585.3 chromosome 2 open reading frame 50 5 2 1 1 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A

RALGDS ENST00000372050.3 ral guanine nucleotide dissociation stimulator 143 2 1 1 0 0 hsa-miR-5001-5p -0.59 -0.59 N/A

SIRT6 ENST00000601488.1 sirtuin 6 10 3 0 2 1 0 hsa-miR-4498 -0.58 -0.58 N/A

UBALD1 ENST00000590965.1 UBA-like domain containing 1 41 2 1 1 0 1 hsa-miR-5001-5p -0.58 -0.58 N/A

ZNF469 ENST00000437464.1 zinc finger protein 469 139 2 0 0 2 1 hsa-miR-4498 -0.58 -0.58 N/A solute carrier family 12 (potassium/chloride transporter), SLC12A4 ENST00000422611.2 1618 7 3 3 1 0 hsa-miR-5001-5p -0.58 -0.89 N/A member 4 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GLIPR2 ENST00000396613.3 GLI pathogenesis-related 2 218 2 0 1 1 4 hsa-miR-4498 -0.58 -0.7 N/A

URM1 ENST00000372850.1 ubiquitin related modifier 1 345 4 0 3 1 4 hsa-miR-5001-5p -0.58 -0.64 N/A

RP11-385D13.1 ENST00000455584.2 Uncharacterized protein 5 2 0 2 0 1 hsa-miR-4498 -0.58 -0.58 N/A

BEGAIN ENST00000355173.2 brain-enriched guanylate kinase-associated 90 3 1 2 0 0 hsa-miR-5001-5p -0.58 -0.58 N/A

TMEM119 ENST00000392806.3 transmembrane protein 119 5 2 0 2 0 2 hsa-miR-4498 -0.58 -0.58 N/A

TMEM229B ENST00000557006.1 transmembrane protein 229B 5 3 0 3 0 3 hsa-miR-4498 -0.58 -0.58 N/A

ZFP3 ENST00000318833.3 ZFP3 zinc finger protein 29 2 0 2 0 1 hsa-miR-4498 -0.58 -0.58 N/A

CDH5 ENST00000341529.3 cadherin 5, type 2 (vascular endothelium) 8 3 1 0 2 0 hsa-miR-5001-5p -0.58 -0.58 N/A

ACVRL1 ENST00000550683.1 activin A receptor type II-like 1 68 5 2 3 0 1 hsa-miR-4498 -0.58 -0.9 N/A

P2RX5 ENST00000551178.1 purinergic receptor P2X, ligand-gated ion channel, 5 260 1 1 0 0 0 hsa-miR-5001-5p -0.58 -0.58 N/A

DUSP8 ENST00000397374.3 dual specificity phosphatase 8 26 6 0 4 2 1 hsa-miR-5001-5p -0.58 -0.67 N/A

ARHGAP39 ENST00000377307.2 Rho GTPase activating protein 39 14 4 0 3 1 0 hsa-miR-4498 -0.58 -0.68 N/A

STAC2 ENST00000333461.5 SH3 and cysteine rich domain 2 123 3 2 1 0 0 hsa-miR-5001-5p -0.58 -1.16 N/A

TMEM151B ENST00000451188.2 transmembrane protein 151B 5 4 0 2 2 3 hsa-miR-5001-5p -0.58 -0.58 N/A

CADM3 ENST00000368125.4 cell adhesion molecule 3 5 3 1 2 0 3 hsa-miR-4498 -0.58 -0.58 N/A

CDR2L ENST00000337231.5 cerebellar degeneration-related protein 2-like 28 4 1 2 1 2 hsa-miR-5001-5p -0.58 -0.58 N/A

MTCH1 ENST00000373616.5 mitochondrial carrier 1 71 2 1 0 1 0 hsa-miR-5001-5p -0.58 -0.58 N/A

MLKL ENST00000306247.7 mixed lineage kinase domain-like 44 1 1 0 0 0 hsa-miR-5001-5p -0.58 -0.58 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS13 ENST00000371916.1 41 5* 0 3 1 1 hsa-miR-4498 -0.58 -0.58 N/A 13 CLIP2 ENST00000223398.6 CAP-GLY domain containing linker protein 2 2111 3 0 1 2 2 hsa-miR-5001-5p -0.58 -0.58 N/A

TFPT ENST00000391757.1 TCF3 (E2A) fusion partner (in childhood Leukemia) 81 1 1 0 0 0 hsa-miR-5001-5p -0.58 -0.58 N/A

STPG1 ENST00000374409.1 sperm-tail PG-rich repeat containing 1 24 2 1 1 0 1 hsa-miR-4498 -0.58 -0.58 N/A

PKLR ENST00000392414.3 pyruvate kinase, liver and RBC 112 1 1 0 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A

CABIN1 ENST00000263119.5 calcineurin binding protein 1 50 1 1 0 0 1 hsa-miR-5001-5p -0.57 -0.57 N/A guanine nucleotide binding protein (G protein), alpha GNAO1 ENST00000262493.6 8 2 0 2 0 1 hsa-miR-5001-5p -0.57 -0.57 N/A activating activity polypeptide O Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMC7 ENST00000421369.3 transmembrane channel-like 7 54 2 1 1 0 0 hsa-miR-4498 -0.57 -0.57 N/A

LZTS1 ENST00000381569.1 leucine zipper, putative tumor suppressor 1 33 8 0 6 2 2 hsa-miR-4498 -0.57 -0.57 N/A

BARHL1 ENST00000263610.2 BarH-like homeobox 1 5 3 1 2 0 2 hsa-miR-4498 -0.57 -0.57 N/A

DOC2B ENST00000343572.7 double C2-like domains, beta 5 1 1 0 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A

BRAT1 ENST00000340611.4 BRCA1-associated ATM activator 1 2308 2 1 1 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A

NOL3 ENST00000432069.2 nucleolar protein 3 (apoptosis repressor with CARD domain) 284 1 1 0 0 1 hsa-miR-5001-5p -0.57 -0.6 N/A

VIMP ENST00000537379.1 VCP-interacting membrane protein 139 1 1 0 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A

TSPAN14 ENST00000429989.3 tetraspanin 14 239 7 2 2 3 4 hsa-miR-5001-5p -0.57 -1.52 N/A

MOCS1 ENST00000373186.4 molybdenum cofactor synthesis 1 179 4 1 1 2 1 hsa-miR-5001-5p -0.57 -0.74 N/A

RAP1GAP2 ENST00000254695.8 RAP1 GTPase activating protein 2 123 5 1 4 0 3 hsa-miR-4498 -0.57 -0.7 N/A

ARHGAP4 ENST00000393721.1 Rho GTPase activating protein 4 5 2 0 2 0 1 hsa-miR-4498 -0.57 -0.57 N/A

LMF2 ENST00000380796.3 lipase maturation factor 2 1375 1 1 0 0 2 hsa-miR-5001-5p -0.57 -0.58 N/A

NTN1 ENST00000173229.2 netrin 1 12 5 2 2 1 3 hsa-miR-4498 -0.57 -0.57 N/A

RABL5 ENST00000517481.1 RAB, member RAS oncogene family-like 5 170 3 2 0 1 0 hsa-miR-4498 -0.57 -1.22 N/A

COX6B2 ENST00000590900.1 cytochrome c oxidase subunit VIb polypeptide 2 (testis) 5 1 1 0 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A solute carrier family 8 (sodium/calcium exchanger), member SLC8A2 ENST00000236877.6 5 3 1 2 0 2 hsa-miR-4498 -0.57 -0.57 N/A 2 KREMEN1 ENST00000400335.4 kringle containing transmembrane protein 1 606 4 0 1 3 1 hsa-miR-4498 -0.57 -0.57 N/A

SLCO2B1 ENST00000289575.5 solute carrier organic anion transporter family, member 2B1 1614 2 2 0 0 1 hsa-miR-5001-5p -0.57 -0.58 N/A

FAM120AOS ENST00000423591.1 family with sequence similarity 120A opposite strand 258 3 0 0 3 1 hsa-miR-5001-5p -0.57 -0.85 N/A leukocyte immunoglobulin-like receptor, subfamily A (with LILRA6 ENST00000391735.3 5 3 1 0 2 1 hsa-miR-5001-5p -0.57 -0.57 N/A TM domain), member 6 CDK18 ENST00000360066.2 cyclin-dependent kinase 18 262 3 0 3 0 2 hsa-miR-4498 -0.57 -0.58 N/A

TEX264 ENST00000341333.5 testis expressed 264 33 2 0 2 0 0 hsa-miR-4498 -0.57 -0.57 N/A

TPD52L1 ENST00000368388.2 tumor protein D52-like 1 1169 1 1 0 0 0 hsa-miR-5001-5p -0.57 -0.57 N/A

RP11-162A12.2 ENST00000585258.1 Uncharacterized protein 5 2 0 1 1 0 hsa-miR-4498 -0.56 -0.56 N/A

EFHD2 ENST00000375980.4 EF-hand domain family, member D2 1411 3 0 3 0 0 hsa-miR-4498 -0.56 -0.56 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PFKFB3 ENST00000536985.1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 29 2 0 2 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

CYP11B1 ENST00000292427.4 cytochrome P450, family 11, subfamily B, polypeptide 1 5 2 0 2 0 0 hsa-miR-4498 -0.56 -0.56 N/A

HNRNPUL1 ENST00000352456.3 heterogeneous nuclear ribonucleoprotein U-like 1 11882 2 1 1 0 1 hsa-miR-4498 -0.56 -0.59 N/A

TINAGL1 ENST00000457433.2 tubulointerstitial nephritis antigen-like 1 48 2 0 2 0 0 hsa-miR-4498 -0.56 -0.56 N/A

KRT71 ENST00000267119.5 keratin 71 5 2 1 0 1 0 hsa-miR-5001-5p -0.56 -0.56 N/A

ASB14 ENST00000487349.1 ankyrin repeat and SOCS box containing 14 5 2 1 1 0 1 hsa-miR-4498 -0.56 -0.56 N/A

IP6K1 ENST00000468463.1 inositol hexakisphosphate kinase 1 406 8 0 7 1 1 hsa-miR-4498 -0.56 -1.13 N/A

SETD1B ENST00000267197.5 SET domain containing 1B 703 2 0 1 1 1 hsa-miR-5001-5p -0.56 -0.56 N/A

HOXC12 ENST00000243103.3 homeobox C12 5 5 1 4 0 3 hsa-miR-4498 -0.56 -0.56 N/A

PPM1H ENST00000228705.6 protein phosphatase, Mg2+/Mn2+ dependent, 1H 45 3 2 0 1 0 hsa-miR-5001-5p -0.56 -0.56 N/A

SLC48A1 ENST00000442218.2 solute carrier family 48 (heme transporter), member 1 470 3 0 2 1 0 hsa-miR-4498 -0.56 -0.67 N/A

TOB2 ENST00000327492.3 transducer of ERBB2, 2 71 4 3 0 1 2 hsa-miR-5001-5p -0.56 -0.61 N/A

PACSIN1 ENST00000244458.2 protein kinase C and casein kinase substrate in neurons 1 25 5 1 3 1 3 hsa-miR-5001-5p -0.56 -0.56 N/A

DES ENST00000373960.3 desmin 5 2 1 1 0 1 hsa-miR-5001-5p -0.56 -0.56 N/A

MMP14 ENST00000311852.6 matrix metallopeptidase 14 (membrane-inserted) 276 3 1 2 0 1 hsa-miR-5001-5p -0.56 -0.56 N/A

TOM1L2 ENST00000581396.1 target of myb1-like 2 (chicken) 35 7 1 6 0 4 hsa-miR-4498 -0.56 -0.89 N/A

FAM213B ENST00000378424.4 family with sequence similarity 213, member B 409 1 1 0 0 3 hsa-miR-5001-5p -0.56 -0.61 N/A

ZNF18 ENST00000580306.2 zinc finger protein 18 69 1 1 0 0 1 hsa-miR-5001-5p -0.56 -0.56 N/A

AL645730.2 ENST00000448346.1 5 1 1 0 0 1 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDH11X ENST00000504220.2 protocadherin 11 X-linked 5 4 0 0 4 3 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGB4 ENST00000519479.1 protocadherin gamma subfamily B, 4 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGB1 ENST00000523390.1 protocadherin gamma subfamily B, 1 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

SYCE2 ENST00000293695.7 synaptonemal complex central element protein 2 5 2 0 2 0 0 hsa-miR-4498 -0.56 -0.56 N/A

PCDHGB3 ENST00000576222.1 protocadherin gamma subfamily B, 3 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGA4 ENST00000571252.1 protocadherin gamma subfamily A, 4 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF594 ENST00000399604.4 zinc finger protein 594 29 2 1 1 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGB7 ENST00000398594.2 protocadherin gamma subfamily B, 7 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGB6 ENST00000520790.1 protocadherin gamma subfamily B, 6 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGB2 ENST00000522605.1 protocadherin gamma subfamily B, 2 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

CDCP1 ENST00000296129.1 CUB domain containing protein 1 137 4 1 2 1 0 hsa-miR-5001-5p -0.56 -0.78 N/A

FAM219B ENST00000357635.5 family with sequence similarity 219, member B 270 2 2 0 0 1 hsa-miR-5001-5p -0.56 -0.61 N/A HCG1652096, isoform CRA_a; Uncharacterized protein; AP003774.4 ENST00000316124.2 5 1 1 0 0 2 hsa-miR-5001-5p -0.56 -0.56 N/A cDNA FLJ37045 fis, clone BRACE2012185 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ST8SIA2 ENST00000268164.3 9 3 1 2 0 1 hsa-miR-4498 -0.56 -0.56 N/A 2 potassium voltage-gated channel, Isk-related family, member KCNE4 ENST00000281830.3 5 2 1 1 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A 4 ZFAND2B ENST00000409594.1 zinc finger, AN1-type domain 2B 132 1 1 0 0 1 hsa-miR-5001-5p -0.56 -0.56 N/A

CLCNKB ENST00000375679.4 chloride channel, voltage-sensitive Kb 5 1 1 0 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

CLCNKA ENST00000375692.1 chloride channel, voltage-sensitive Ka 5 1 1 0 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

C21orf67 ENST00000397841.1 chromosome 21 open reading frame 67 19 2 1 1 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

RP11-1070N10.3 ENST00000554161.1 Uncharacterized protein 5 1 1 0 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

WDR86 ENST00000334493.6 WD repeat domain 86 5 2 1 1 0 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGC4 ENST00000306593.1 protocadherin gamma subfamily C, 4 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

PCDHGC3 ENST00000308177.3 protocadherin gamma subfamily C, 3 145 4 1 1 2 0 hsa-miR-5001-5p -0.56 -0.56 N/A

EGFR ENST00000275493.2 epidermal growth factor receptor 632 2 1 0 1 3 hsa-miR-5001-5p -0.55 -0.59 N/A

CES3 ENST00000543856.1 carboxylesterase 3 10 3 0 3 0 4 hsa-miR-4498 -0.55 -0.79 N/A

BEAN1 ENST00000299694.8 brain expressed, associated with NEDD4, 1 16 2 1 0 1 0 hsa-miR-5001-5p -0.55 -0.55 N/A

PCDHGC5 ENST00000252087.1 protocadherin gamma subfamily C, 5 145 4 1 1 2 0 hsa-miR-5001-5p -0.55 -0.55 N/A

NME4 ENST00000219479.2 NME/NM23 nucleoside diphosphate kinase 4 4249 1 1 0 0 0 hsa-miR-4498 -0.55 -0.55 N/A LL22NC03- ENST00000405369.3 Novel protein; Uncharacterized protein 5 2 0 1 1 0 hsa-miR-4498 -0.55 -0.55 N/A 75H12.2 ANAPC15 ENST00000543587.1 anaphase promoting complex subunit 15 36 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.55 N/A

GPR37L1 ENST00000367282.5 G protein-coupled receptor 37 like 1 5 8 1 7 0 2 hsa-miR-4498 -0.55 -0.55 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score fascin homolog 1, actin-bundling protein (Strongylocentrotus FSCN1 ENST00000382361.3 192 3 0 3 0 3 hsa-miR-4498 -0.55 -0.62 N/A purpuratus) PRR3 ENST00000376560.3 proline rich 3 1145 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.57 N/A

NME3 ENST00000219302.3 NME/NM23 nucleoside diphosphate kinase 3 3070 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.55 N/A

USP6 ENST00000332776.4 ubiquitin specific peptidase 6 (Tre-2 oncogene) 5 2 0 0 2 3 hsa-miR-5001-5p -0.55 -0.55 N/A

TMEM104 ENST00000335464.5 transmembrane protein 104 657 4 2 2 0 2 hsa-miR-4498 -0.55 -0.59 N/A

LIN54 ENST00000395282.2 lin-54 homolog (C. elegans) 228 2 2 0 0 0 hsa-miR-5001-5p -0.55 -0.7 N/A

CCDC64 ENST00000397558.2 coiled-coil domain containing 64 7 4 0 3 1 1 hsa-miR-4498 -0.55 -0.55 N/A

MEF2B ENST00000409224.1 myocyte enhancer factor 2B 35 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.55 N/A

WDTC1 ENST00000319394.3 WD and tetratricopeptide repeats 1 137 4 1 3 0 4 hsa-miR-4498 -0.55 -0.6 N/A

TYSND1 ENST00000335494.5 trypsin domain containing 1 35 2 1 1 0 3 hsa-miR-4498 -0.55 -0.55 N/A

RPIA ENST00000283646.4 ribose 5-phosphate isomerase A 415 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.55 N/A

CCDC9 ENST00000221922.6 coiled-coil domain containing 9 391 3 0 2 1 3 hsa-miR-5001-5p -0.55 -0.74 N/A

KRT78 ENST00000359499.4 keratin 78 5 2 1 0 1 1 hsa-miR-5001-5p -0.55 -0.55 N/A

NAP1L3 ENST00000373079.3 nucleosome assembly protein 1-like 3 5 1 1 0 0 0 hsa-miR-5001-5p -0.55 -0.55 N/A

EMP2 ENST00000359543.3 epithelial membrane protein 2 1725 2 1 1 0 2 hsa-miR-4498 -0.54 -0.59 N/A

ZNF132 ENST00000254166.3 zinc finger protein 132 31 2 2 0 0 0 hsa-miR-5001-5p -0.54 -0.63 N/A

POLR2D ENST00000272645.4 polymerase (RNA) II (DNA directed) polypeptide D 530 4 0 1 3 0 hsa-miR-4498 -0.54 -0.56 N/A

CHST3 ENST00000373115.4 carbohydrate (chondroitin 6) sulfotransferase 3 217 3 0 3 0 4 hsa-miR-4498 -0.54 -0.56 N/A

C17orf107 ENST00000381365.3 chromosome 17 open reading frame 107 11 4 0 4 0 0 hsa-miR-4498 -0.54 -0.54 N/A

SMYD5 ENST00000389501.4 SMYD family member 5 344 2 0 2 0 0 hsa-miR-4498 -0.54 -0.54 N/A

MYO1C ENST00000359786.5 myosin IC 1073 4 1 1 2 1 hsa-miR-5001-5p -0.54 -0.56 N/A TRAF-interacting protein with forkhead-associated domain, TIFAB ENST00000537858.1 5 5 1 1 3 3 hsa-miR-5001-5p -0.54 -0.54 N/A family member B CALML6 ENST00000307786.3 calmodulin-like 6 5 1 0 1 0 0 hsa-miR-4498 -0.54 -0.54 N/A Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA SEPSECS ENST00000302922.3 279 2 1 0 1 0 hsa-miR-4498 -0.54 -0.56 N/A synthase TRIM58 ENST00000366481.3 tripartite motif containing 58 68 2 2 0 0 1 hsa-miR-5001-5p -0.54 -0.56 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CCDC135 ENST00000394337.4 coiled-coil domain containing 135 11 1 1 0 0 1 hsa-miR-5001-5p -0.54 -0.54 N/A

AJAP1 ENST00000378191.4 adherens junctions associated protein 1 5 6 0 4 2 2 hsa-miR-4498 -0.54 -0.54 N/A

MGRN1 ENST00000415496.1 mahogunin ring finger 1, E3 ubiquitin protein ligase 2337 5 1 3 1 3 hsa-miR-5001-5p -0.54 -0.54 N/A solute carrier family 29 (equilibrative nucleoside SLC29A4 ENST00000396872.3 61 4 1 2 1 2 hsa-miR-5001-5p -0.54 -0.96 N/A transporter), member 4 CENPP ENST00000375587.3 centromere protein P 85 11 4 5 2 3 hsa-miR-5001-5p -0.54 -0.92 N/A solute carrier family 11 (proton-coupled divalent metal ion SLC11A1 ENST00000233202.6 33 2 1 0 1 1 hsa-miR-5001-5p -0.54 -0.54 N/A transporter), member 1 HPCA ENST00000373467.3 hippocalcin 5 2 0 2 0 0 hsa-miR-4498 -0.54 -0.54 N/A

BCAM ENST00000270233.6 basal cell adhesion molecule (Lutheran blood group) 4647 2 0 2 0 0 hsa-miR-4498 -0.54 -0.54 N/A

CASKIN2 ENST00000321617.3 CASK interacting protein 2 92 2 1 0 1 2 hsa-miR-4498 -0.54 -0.54 N/A

FPGS ENST00000373245.1 folylpolyglutamate synthase 117 4 3 1 0 1 hsa-miR-4498 -0.53 -1.62 N/A

BRK1 ENST00000530758.1 BRICK1, SCAR/WAVE actin-nucleating complex subunit 1508 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.55 N/A

ADRA1A ENST00000380586.1 adrenoceptor alpha 1A 5 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.53 N/A

SLIT3 ENST00000519560.1 slit homolog 3 (Drosophila) 13 2 1 1 0 4 hsa-miR-5001-5p -0.53 -0.85 N/A

TRIM28 ENST00000253024.5 tripartite motif containing 28 3546 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.53 N/A

MOSPD3 ENST00000393950.2 motile sperm domain containing 3 106 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.53 N/A polymerase (RNA) II (DNA directed) polypeptide A, POLR2A ENST00000322644.6 7006 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.53 N/A 220kDa phospholipase A2, group VI (cytosolic, calcium- PLA2G6 ENST00000332509.3 74 4 0 3 1 1 hsa-miR-4498 -0.53 -0.53 N/A independent) GPR173 ENST00000332582.4 G protein-coupled receptor 173 99 5 0 4 1 0 hsa-miR-4498 -0.53 -0.53 N/A

PANK4 ENST00000378466.3 pantothenate kinase 4 72 7 0 6 1 5 hsa-miR-4498 -0.53 -0.98 N/A

LHX3 ENST00000371746.3 LIM homeobox 3 5 3 1 2 0 0 hsa-miR-4498 -0.53 -0.53 N/A

PRR24 ENST00000552360.2 proline rich 24 282 2 0 1 1 0 hsa-miR-5001-5p -0.53 -0.53 N/A

SRRM4 ENST00000267260.4 serine/arginine repetitive matrix 4 22 4 0 3 1 2 hsa-miR-4498 -0.53 -0.53 N/A

MEX3B ENST00000558133.1 mex-3 RNA binding family member B 1401 3 1 1 1 1 hsa-miR-5001-5p -0.53 -0.53 N/A

MRPL43 ENST00000477279.1 mitochondrial ribosomal protein L43 502 1 1 0 0 1 hsa-miR-5001-5p -0.53 -0.53 N/A

NDOR1 ENST00000427047.2 NADPH dependent diflavin oxidoreductase 1 1044 4 1 2 1 3 hsa-miR-4498 -0.53 -0.56 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TFR2 ENST00000431692.1 transferrin receptor 2 330 2 0 2 0 1 hsa-miR-4498 -0.53 -0.53 N/A

C1orf64 ENST00000329454.2 chromosome 1 open reading frame 64 5 3 1 1 1 0 hsa-miR-5001-5p -0.53 -0.53 N/A

TRH ENST00000302649.3 thyrotropin-releasing hormone 5 2 0 2 0 0 hsa-miR-4498 -0.53 -0.53 N/A

BHMT2 ENST00000255192.3 betaine--homocysteine S-methyltransferase 2 297 1 1 0 0 1 hsa-miR-5001-5p -0.53 -0.53 N/A

SSSCA1 ENST00000526877.1 Sjogren syndrome/scleroderma autoantigen 1 96 3 0 2 1 1 hsa-miR-4498 -0.53 -0.82 N/A

KCTD15 ENST00000284006.6 potassium channel tetramerization domain containing 15 2483 2 0 1 1 1 hsa-miR-5001-5p -0.53 -0.54 N/A

MSI1 ENST00000257552.2 musashi RNA-binding protein 1 287 3 0 2 1 2 hsa-miR-4498 -0.53 -0.53 N/A

SEC14L5 ENST00000251170.7 SEC14-like 5 (S. cerevisiae) 5 3 3 0 0 1 hsa-miR-5001-5p -0.53 -0.53 N/A

AAMP ENST00000248450.4 angio-associated, migratory cell protein 95 1 1 0 0 0 hsa-miR-5001-5p -0.53 -0.53 N/A

ZNF488 ENST00000494156.1 zinc finger protein 488 61 2 0 1 1 2 hsa-miR-4498 -0.53 -0.59 N/A

PTGER1 ENST00000292513.3 prostaglandin E receptor 1 (subtype EP1), 42kDa 7 1 1 0 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

PGAP3 ENST00000579146.1 post-GPI attachment to proteins 3 6 2 1 1 0 3 hsa-miR-4498 -0.52 -0.52 N/A

SCGN ENST00000334979.6 secretagogin, EF-hand calcium binding protein 590 1 1 0 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

ABR ENST00000302538.5 active BCR-related 58 3 1 2 0 3 hsa-miR-5001-5p -0.52 -0.64 N/A

FAM127B ENST00000370775.2 family with sequence similarity 127, member B 647 1 1 0 0 1 hsa-miR-5001-5p -0.52 -0.52 N/A

LRRC4B ENST00000599957.1 leucine rich repeat containing 4B 5 4 1 3 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

TRAPPC9 ENST00000389328.4 trafficking protein particle complex 9 251 6 1 3 2 6 hsa-miR-4498 -0.52 -0.61 N/A

CTC-260F20.3 ENST00000555938.1 Uncharacterized protein 5 1 1 0 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

EFNB3 ENST00000226091.2 ephrin-B3 5 3 0 2 1 1 hsa-miR-4498 -0.52 -0.52 N/A

PTGES2 ENST00000338961.6 prostaglandin E synthase 2 250 2 0 2 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

G6PC ENST00000253801.2 glucose-6-phosphatase, catalytic subunit 5 3 1 1 1 0 hsa-miR-5001-5p -0.52 -0.87 N/A solute carrier family 6 (neurotransmitter transporter), SLC6A8 ENST00000253122.5 5 2 0 2 0 2 hsa-miR-4498 -0.52 -0.52 N/A member 8 BRSK2 ENST00000382179.1 BR serine/threonine kinase 2 15 3 1 2 0 2 hsa-miR-5001-5p -0.52 -0.71 N/A

HOXA11 ENST00000006015.3 homeobox A11 133 2 0 1 1 1 hsa-miR-5001-5p -0.52 -0.52 N/A

ABCG4 ENST00000307417.3 ATP-binding cassette, sub-family G (WHITE), member 4 5 3 0 3 0 1 hsa-miR-4498 -0.52 -0.52 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AEBP1 ENST00000450684.2 AE binding protein 1 246 1 1 0 0 0 hsa-miR-5001-5p -0.52 -0.52 N/A

SERINC4 ENST00000299969.6 serine incorporator 4 9 2 1 1 0 1 hsa-miR-5001-5p -0.52 -0.52 N/A

POU2F3 ENST00000260264.4 POU class 2 homeobox 3 5 1 1 0 0 1 hsa-miR-4498 -0.52 -0.52 N/A

RAVER1 ENST00000293677.6 ribonucleoprotein, PTB-binding 1 362 1 1 0 0 2 hsa-miR-5001-5p -0.52 -0.52 N/A

SAMD10 ENST00000369886.3 sterile alpha motif domain containing 10 45 2 1 1 0 0 hsa-miR-4498 -0.52 -0.52 N/A

FAM78A ENST00000372269.3 family with sequence similarity 78, member A 7 3 1 2 0 1 hsa-miR-4498 -0.52 -0.69 N/A

FBXW8 ENST00000455858.2 F-box and WD repeat domain containing 8 169 5 2 2 1 1 hsa-miR-5001-5p -0.52 -0.74 N/A

CNP ENST00000393892.3 2',3'-cyclic nucleotide 3' phosphodiesterase 399 3 3 0 0 2 hsa-miR-5001-5p -0.52 -0.61 N/A

ARHGAP40 ENST00000373345.4 Rho GTPase activating protein 40 5 2 0 2 0 1 hsa-miR-4498 -0.52 -0.52 N/A

CRCT1 ENST00000368790.3 cysteine-rich C-terminal 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.51 -0.51 N/A

UAP1L1 ENST00000360271.3 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 398 4 1 2 1 0 hsa-miR-5001-5p -0.51 -0.51 N/A

FXYD6 ENST00000540359.1 FXYD domain containing ion transport regulator 6 42 2 0 1 1 2 hsa-miR-4498 -0.51 -0.51 N/A

RP11-1055B8.7 ENST00000307745.7 BAH and coiled-coil domain-containing protein 1 247 2 0 1 1 1 hsa-miR-5001-5p -0.51 -0.52 N/A

SLMO1 ENST00000592149.1 slowmo homolog 1 (Drosophila) 123 3 0 3 0 1 hsa-miR-5001-5p -0.51 -0.51 N/A

AC006455.1 ENST00000456890.1 5 2 0 1 1 0 hsa-miR-4498 -0.51 -0.51 N/A

HAND1 ENST00000231121.2 heart and neural crest derivatives expressed 1 5 1 1 0 0 2 hsa-miR-4498 -0.51 -0.51 N/A CDNA FLJ26875 fis, clone PRS08969; Uncharacterized AL031663.2 ENST00000595203.1 22 2 0 1 1 0 hsa-miR-4498 -0.51 -0.51 N/A protein v-erb-b2 avian erythroblastic leukemia viral oncogene ERBB2 ENST00000584450.1 511 3 0 1 2 1 hsa-miR-4498 -0.51 -0.51 N/A homolog 2 PNPLA5 ENST00000597664.1 patatin-like phospholipase domain containing 5 5 2 2 0 0 0 hsa-miR-5001-5p -0.51 -0.51 N/A

FOXJ1 ENST00000322957.6 forkhead box J1 5 3 0 3 0 0 hsa-miR-4498 -0.51 -0.51 N/A

EFNA5 ENST00000333274.6 ephrin-A5 225 2 0 2 0 1 hsa-miR-5001-5p -0.51 -0.51 N/A

C22orf24 ENST00000248984.3 chromosome 22 open reading frame 24 5 1 1 0 0 1 hsa-miR-5001-5p -0.51 -0.51 N/A

TNS3 ENST00000311160.9 tensin 3 28 2 0 2 0 1 hsa-miR-4498 -0.51 -0.51 N/A

ZNF395 ENST00000344423.5 zinc finger protein 395 1044 3 1 2 0 0 hsa-miR-4498 -0.51 -0.52 N/A

TXNRD3NB ENST00000383572.2 thioredoxin reductase 3 neighbor 10 6 2 2 2 2 hsa-miR-5001-5p -0.51 -1.25 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NT5DC3 ENST00000392876.3 5'-nucleotidase domain containing 3 235 4 0 1 3 0 hsa-miR-5001-5p -0.51 -0.51 N/A

PYGM ENST00000377432.3 phosphorylase, glycogen, muscle 5 2 0 2 0 0 hsa-miR-4498 -0.51 -0.51 N/A

PRSS8 ENST00000317508.6 protease, serine, 8 5 1 1 0 0 0 hsa-miR-5001-5p -0.51 -0.51 N/A

NRL ENST00000397002.2 neural retina leucine zipper 9 2 1 0 1 0 hsa-miR-5001-5p -0.51 -0.53 N/A

PELI3 ENST00000320740.7 pellino E3 ubiquitin protein ligase family member 3 257 6 0 3 3 0 hsa-miR-4498 -0.51 -0.65 N/A

TMEM86B ENST00000327042.4 transmembrane protein 86B 2783 1 1 0 0 0 hsa-miR-5001-5p -0.51 -0.51 N/A

TMEM95 ENST00000330767.4 transmembrane protein 95 5 1 0 1 0 1 hsa-miR-4498 -0.5 -0.5 N/A

ARHGAP20 ENST00000260283.4 Rho GTPase activating protein 20 85 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

MVB12B ENST00000361171.3 multivesicular body subunit 12B 29 4 0 3 1 6 hsa-miR-5001-5p -0.5 -0.5 N/A

TPSD1 ENST00000397534.2 tryptase delta 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A fucosyltransferase 1 (galactoside 2-alpha-L- FUT1 ENST00000310160.3 17 2 1 1 0 1 hsa-miR-5001-5p -0.5 -0.5 N/A fucosyltransferase, H blood group) PHF17 ENST00000226319.6 PHD finger protein 17 1393 2 1 0 1 0 hsa-miR-5001-5p -0.5 -0.51 N/A

MAF1 ENST00000322428.5 MAF1 homolog (S. cerevisiae) 698 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

C21orf49 ENST00000382375.4 chromosome 21 open reading frame 49 5 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

TTC7B ENST00000328459.6 tetratricopeptide repeat domain 7B 20 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A solute carrier family 6 (neurotransmitter transporter), SLC6A6 ENST00000454876.2 280 5 1 3 1 4 hsa-miR-4498 -0.5 -0.53 N/A member 6 PLCH2 ENST00000449969.1 phospholipase C, eta 2 5 4 1 2 1 0 hsa-miR-5001-5p -0.5 -0.5 N/A

KLLN ENST00000445946.3 killin, p53-regulated DNA replication inhibitor 5 3 1 0 2 1 hsa-miR-5001-5p -0.5 -0.5 N/A

NRAP ENST00000369360.3 nebulin-related anchoring protein 5 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

WDR48 ENST00000302313.5 WD repeat domain 48 638 3 1 1 1 0 hsa-miR-5001-5p -0.5 -0.73 N/A

AP000679.2 ENST00000319763.1 Uncharacterized protein 5 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

SMIM5 ENST00000375215.3 small integral membrane protein 5 5 1 1 0 0 1 hsa-miR-5001-5p -0.5 -0.5 N/A

GTPBP1 ENST00000216044.5 GTP binding protein 1 1765 3 0 3 0 1 hsa-miR-4498 -0.5 -0.51 N/A

PRKCSH ENST00000252455.2 protein kinase C substrate 80K-H 3617 2 0 2 0 0 hsa-miR-4498 -0.5 -0.5 N/A

TMEM199 ENST00000292114.3 transmembrane protein 199 739 1 1 0 0 1 hsa-miR-5001-5p -0.5 -0.52 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score UPK2 ENST00000264031.2 uroplakin 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.5 -0.5 N/A

AFF3 ENST00000409236.2 AF4/FMR2 family, member 3 296 3 1 2 0 2 hsa-miR-4498 -0.5 -0.84 N/A

NR2C2 ENST00000425241.1 nuclear receptor subfamily 2, group C, member 2 227 5 0 4 1 1 hsa-miR-4498 -0.5 -0.82 N/A

RAMP3 ENST00000481345.1 receptor (G protein-coupled) activity modifying protein 3 5 1 0 1 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A

AC135983.2 ENST00000593303.1 Protein LOC100996413 5 1 0 1 0 2 hsa-miR-4498 -0.49 -0.49 N/A

RNF20 ENST00000389120.3 ring finger protein 20, E3 ubiquitin protein ligase 772 2 2 0 0 2 hsa-miR-5001-5p -0.49 -0.6 N/A

SCN4A ENST00000578147.1 sodium channel, voltage-gated, type IV, alpha subunit 5 2 2 0 0 4 hsa-miR-5001-5p -0.49 -0.49 N/A human immunodeficiency virus type I enhancer binding HIVEP3 ENST00000372583.1 84 2 1 0 1 2 hsa-miR-4498 -0.49 -0.49 N/A protein 3 PIK3R6 ENST00000311434.9 phosphoinositide-3-kinase, regulatory subunit 6 5 2 0 1 1 0 hsa-miR-5001-5p -0.49 -0.49 N/A

PRLHR ENST00000239032.2 prolactin releasing hormone receptor 5 1 1 0 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A ArfGAP with GTPase domain, ankyrin repeat and PH AGAP2 ENST00000257897.3 12 3 0 3 0 1 hsa-miR-4498 -0.49 -0.49 N/A domain 2 GRK5 ENST00000392870.2 G protein-coupled receptor kinase 5 337 4 3 1 0 3 hsa-miR-5001-5p -0.49 -0.71 N/A

RNF38 ENST00000259605.6 ring finger protein 38 348 3 0 3 0 0 hsa-miR-4498 -0.49 -0.51 N/A

MUS81 ENST00000533035.1 MUS81 structure-specific endonuclease subunit 43 1 0 1 0 1 hsa-miR-4498 -0.49 -0.49 N/A

ZNF20 ENST00000334213.5 zinc finger protein 20 119 1 1 0 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A SYS1 Golgi-localized integral membrane protein homolog SYS1 ENST00000243918.5 384 1 1 0 0 1 hsa-miR-5001-5p -0.49 -0.52 N/A (S. cerevisiae) REEP2 ENST00000254901.5 receptor accessory protein 2 606 2 1 1 0 1 hsa-miR-5001-5p -0.49 -0.5 N/A

SERHL2 ENST00000340239.4 serine hydrolase-like 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A

SH2B1 ENST00000359285.5 SH2B adaptor protein 1 39 3 0 3 0 1 hsa-miR-4498 -0.49 -0.49 N/A

GPSM3 ENST00000487761.1 G-protein signaling modulator 3 125 2 0 1 1 1 hsa-miR-5001-5p -0.49 -0.49 N/A

MAP3K3 ENST00000361357.3 mitogen-activated protein kinase kinase kinase 3 144 1 0 0 1 4 hsa-miR-5001-5p -0.49 -0.52 N/A

AL627309.1 ENST00000423372.3 Uncharacterized protein 5 2 2 0 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A

C1orf61 ENST00000368243.1 chromosome 1 open reading frame 61 5 1 1 0 0 0 hsa-miR-5001-5p -0.49 -0.49 N/A transporter 2, ATP-binding cassette, sub-family B TAP2 ENST00000374897.2 466 1 1 0 0 2 hsa-miR-5001-5p -0.49 -0.51 N/A (MDR/TAP) dysbindin (dystrobrevin binding protein 1) domain DBNDD1 ENST00000304733.3 303 2 0 1 1 0 hsa-miR-5001-5p -0.49 -0.49 N/A containing 1 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CYP3A5 ENST00000339843.2 cytochrome P450, family 3, subfamily A, polypeptide 5 5 2 0 1 1 0 hsa-miR-5001-5p -0.49 -0.49 N/A

TLX1 ENST00000467928.2 T-cell leukemia homeobox 1 47 2 1 0 1 0 hsa-miR-5001-5p -0.49 -0.56 N/A

NSUN5 ENST00000428206.1 NOP2/Sun domain family, member 5 28 1 1 0 0 1 hsa-miR-5001-5p -0.48 -0.48 N/A

STAC ENST00000273183.3 SH3 and cysteine rich domain 172 2 0 2 0 1 hsa-miR-5001-5p -0.48 -0.48 N/A

TMEM231 ENST00000258173.6 transmembrane protein 231 243 2 1 0 1 3 hsa-miR-5001-5p -0.48 -0.48 N/A

OVOL1 ENST00000335987.3 ovo-like 1(Drosophila) 5 3 1 1 1 1 hsa-miR-5001-5p -0.48 -0.48 N/A phosphatidylinositol-specific phospholipase C, X domain PLCXD1 ENST00000381657.2 5 5 1 2 2 1 hsa-miR-5001-5p -0.48 -0.48 N/A containing 1 RPS17 ENST00000559187.1 ribosomal protein S17 5 1 1 0 0 2 hsa-miR-5001-5p -0.48 -0.48 N/A

C22orf23 ENST00000403305.1 chromosome 22 open reading frame 23 6 1 1 0 0 1 hsa-miR-5001-5p -0.48 -0.48 N/A ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N- ST6GALNAC2 ENST00000225276.5 37 1 1 0 0 0 hsa-miR-5001-5p -0.48 -0.48 N/A acetylgalactosaminide alpha-2,6-sialyltransferase 2 GTF3C5 ENST00000342018.8 general transcription factor IIIC, polypeptide 5, 63kDa 593 1 1 0 0 0 hsa-miR-5001-5p -0.48 -0.48 N/A

RPS17L ENST00000561157.1 ribosomal protein S17-like 5 1 1 0 0 2 hsa-miR-5001-5p -0.48 -0.48 N/A

IQSEC2 ENST00000375365.2 IQ motif and Sec7 domain 2 5 4 3 1 0 5 hsa-miR-5001-5p -0.48 -0.77 N/A

MRTO4 ENST00000330263.4 mRNA turnover 4 homolog (S. cerevisiae) 2127 7 1 3 3 0 hsa-miR-5001-5p -0.48 -1.74 N/A

LY6K ENST00000522591.1 lymphocyte antigen 6 complex, locus K 2718 2 0 2 0 0 hsa-miR-4498 -0.48 -0.48 N/A

WNT7B ENST00000339464.4 wingless-type MMTV integration site family, member 7B 40 3 1 1 1 1 hsa-miR-5001-5p -0.48 -0.48 N/A

C16orf45 ENST00000300006.4 chromosome 16 open reading frame 45 60 2 0 2 0 0 hsa-miR-4498 -0.48 -0.48 N/A

LRRTM3 ENST00000361320.4 leucine rich repeat transmembrane neuronal 3 5 1 1 0 0 0 hsa-miR-5001-5p -0.48 -0.48 N/A

ZNF551 ENST00000282296.5 zinc finger protein 551 49 3 1 2 0 0 hsa-miR-4498 -0.48 -0.66 N/A

DENND6B ENST00000413817.3 DENN/MADD domain containing 6B 15 8 1 3 4 1 hsa-miR-5001-5p -0.48 -0.95 N/A

ZNF513 ENST00000323703.6 zinc finger protein 513 11 1 1 0 0 0 hsa-miR-4498 -0.48 -0.48 N/A

STRA6 ENST00000395105.4 stimulated by retinoic acid 6 42 2 1 0 1 0 hsa-miR-5001-5p -0.48 -0.48 N/A glutamate receptor, ionotropic, delta 2 (Grid2) interacting GRID2IP ENST00000452113.1 5 2 0 1 1 0 hsa-miR-5001-5p -0.48 -0.48 N/A protein LRRC29 ENST00000409509.1 leucine rich repeat containing 29 5 2 0 1 1 0 hsa-miR-5001-5p -0.48 -0.48 N/A solute carrier family 18 (vesicular acetylcholine transporter), SLC18A3 ENST00000374115.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.48 -0.48 N/A member 3 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF703 ENST00000331569.4 zinc finger protein 703 1557 4 1 3 0 2 hsa-miR-4498 -0.48 -0.77 N/A

SEPN1 ENST00000361547.2 selenoprotein N, 1 104 3 0 1 2 2 hsa-miR-4498 -0.48 -0.51 N/A

NR6A1 ENST00000487099.2 nuclear receptor subfamily 6, group A, member 1 1082 3 1 2 0 0 hsa-miR-5001-5p -0.48 -0.49 N/A

PPIL2 ENST00000406385.1 peptidylprolyl isomerase (cyclophilin)-like 2 1911 3 1 0 2 3 hsa-miR-5001-5p -0.48 -0.49 N/A

RING1 ENST00000374656.4 ring finger protein 1 66 1 1 0 0 0 hsa-miR-5001-5p -0.48 -0.48 N/A

GAST ENST00000329402.3 gastrin 9 1 0 1 0 0 hsa-miR-4498 -0.48 -0.48 N/A

DPP9 ENST00000594671.1 dipeptidyl-peptidase 9 422 3 1 2 0 1 hsa-miR-5001-5p -0.48 -0.48 N/A

PAX8 ENST00000263335.7 paired box 8 11 2 1 1 0 1 hsa-miR-4498 -0.48 -0.48 N/A

ARRB2 ENST00000575877.1 arrestin, beta 2 158 2 0 2 0 0 hsa-miR-4498 -0.48 -0.48 N/A

TMEM201 ENST00000340305.5 transmembrane protein 201 164 3 1 1 1 2 hsa-miR-4498 -0.48 -0.48 N/A

PLA2G2C ENST00000429261.2 phospholipase A2, group IIC 5 2 0 1 1 1 hsa-miR-4498 -0.48 -0.48 N/A

G6PC3 ENST00000269097.4 glucose 6 phosphatase, catalytic, 3 429 3 0 3 0 6 hsa-miR-4498 -0.48 -1.27 N/A

KLHL21 ENST00000377663.3 kelch-like family member 21 45 4 2 0 2 1 hsa-miR-5001-5p -0.48 -0.48 N/A

TNFSF14 ENST00000245912.3 tumor necrosis factor (ligand) superfamily, member 14 5 2 1 1 0 0 hsa-miR-4498 -0.48 -0.48 N/A

TGOLN2 ENST00000377386.3 trans-golgi network protein 2 1914 3 1 1 1 1 hsa-miR-4498 -0.48 -0.54 N/A

RP11-156E8.1 ENST00000607453.1 51 3 1 2 0 1 hsa-miR-5001-5p -0.48 -0.58 N/A

LDLRAD2 ENST00000344642.2 low density lipoprotein receptor class A domain containing 2 5 3 2 0 1 1 hsa-miR-5001-5p -0.48 -0.48 N/A

AGFG2 ENST00000262935.4 ArfGAP with FG repeats 2 3985 4 2 2 0 0 hsa-miR-5001-5p -0.48 -1.13 N/A

RAB15 ENST00000436278.2 RAB15, member RAS oncogene family 23 3 0 3 0 1 hsa-miR-4498 -0.48 -0.57 N/A

ONECUT3 ENST00000382349.4 one cut homeobox 3 5 4 2 2 0 2 hsa-miR-5001-5p -0.47 -0.47 N/A

PRR5 ENST00000403581.1 proline rich 5 (renal) 77 2 0 2 0 0 hsa-miR-4498 -0.47 -0.53 N/A

MYL12A ENST00000217652.3 myosin, light chain 12A, regulatory, non-sarcomeric 52535 1 0 1 0 0 hsa-miR-4498 -0.47 -0.48 N/A

TNC ENST00000340094.3 tenascin C 4571 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

WDR18 ENST00000251289.5 WD repeat domain 18 2963 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

MOBP ENST00000420739.1 myelin-associated oligodendrocyte basic protein 5 4 1 1 2 0 hsa-miR-4498 -0.47 -0.98 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM107 ENST00000532998.1 transmembrane protein 107 585 2 0 2 0 0 hsa-miR-4498 -0.47 -0.48 N/A

SLC10A3 ENST00000369649.4 solute carrier family 10, member 3 433 1 0 1 0 1 hsa-miR-5001-5p -0.47 -0.47 N/A

C9orf141 ENST00000371629.1 chromosome 9 open reading frame 141 5 2 0 1 1 0 hsa-miR-5001-5p -0.47 -0.47 N/A

PSMG4 ENST00000473000.2 proteasome (prosome, macropain) assembly chaperone 4 1452 2 0 2 0 1 hsa-miR-4498 -0.47 -0.48 N/A

CPNE2 ENST00000290776.8 copine II 1469 1 1 0 0 1 hsa-miR-5001-5p -0.47 -0.5 N/A

GPAT2 ENST00000377137.3 glycerol-3-phosphate acyltransferase 2, mitochondrial 5 1 1 0 0 1 hsa-miR-5001-5p -0.47 -0.47 N/A ArfGAP with RhoGAP domain, ankyrin repeat and PH ARAP3 ENST00000508305.1 95 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A domain 3 VASH1 ENST00000167106.4 vasohibin 1 39 2 0 1 1 2 hsa-miR-5001-5p -0.47 -0.47 N/A

PRSS38 ENST00000366757.3 protease, serine, 38 5 2* 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

CATSPERG ENST00000215069.4 catsper channel auxiliary subunit gamma 5 2 1 1 0 1 hsa-miR-5001-5p -0.47 -0.47 N/A

HLA-G ENST00000376828.2 major histocompatibility complex, class I, G 5 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

TREM2 ENST00000373122.4 triggering receptor expressed on myeloid cells 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

MLX ENST00000435881.2 MLX, MAX dimerization protein 771 2 0 2 0 1 hsa-miR-4498 -0.47 -0.67 N/A

FAM86C1 ENST00000359244.4 family with sequence similarity 86, member C1 5 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

CACTIN ENST00000429344.2 cactin, spliceosome C complex subunit 1422 4 0 3 1 1 hsa-miR-4498 -0.47 -0.47 N/A solute carrier family 29 (equilibrative nucleoside SLC29A2 ENST00000311161.7 198 2 2 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A transporter), member 2 BHLHA15 ENST00000609256.1 basic helix-loop-helix family, member a15 136 4 0 3 1 4 hsa-miR-4498 -0.47 -0.48 N/A

VPS37D ENST00000451519.1 vacuolar protein sorting 37 homolog D (S. cerevisiae) 173 2 0 2 0 0 hsa-miR-4498 -0.47 -0.47 N/A

TMEM178B ENST00000565468.1 transmembrane protein 178B 129 4 2 2 0 2 hsa-miR-5001-5p -0.47 -0.47 N/A

CTD-2162K18.4 ENST00000590750.1 Uncharacterized protein 51 1 1 0 0 1 hsa-miR-5001-5p -0.47 -0.47 N/A

CTCF ENST00000264010.4 CCCTC-binding factor (zinc finger protein) 1037 1 1 0 0 1 hsa-miR-5001-5p -0.47 -0.47 N/A

TMEM222 ENST00000374076.4 transmembrane protein 222 312 3 0 2 1 1 hsa-miR-4498 -0.47 -0.47 N/A

TPPP ENST00000360578.5 tubulin polymerization promoting protein 7 5 0 2 3 3 hsa-miR-4498 -0.47 -0.47 N/A

C11orf86 ENST00000308963.4 chromosome 11 open reading frame 86 5 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A

PARP3 ENST00000431474.1 poly (ADP-ribose) polymerase family, member 3 5 1 1 0 0 0 hsa-miR-5001-5p -0.47 -0.47 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FBXL18 ENST00000382368.3 F-box and leucine-rich repeat protein 18 92 5 1 3 1 2 hsa-miR-4498 -0.47 -0.51 N/A

KIAA0226L ENST00000378781.3 KIAA0226-like 21 2 1 0 1 0 hsa-miR-4498 -0.47 -0.47 N/A

DMTN ENST00000265800.5 dematin actin binding protein 333 2 0 2 0 0 hsa-miR-4498 -0.47 -0.47 N/A

TBC1D3B ENST00000454519.3 TBC1 domain family, member 3B 5 2 0 2 0 0 hsa-miR-4498 -0.47 -0.47 N/A

ACSF3 ENST00000317447.4 acyl-CoA synthetase family member 3 40 6 0 6 0 0 hsa-miR-4498 -0.46 -0.61 N/A

F2RL3 ENST00000248076.3 coagulation factor II (thrombin) receptor-like 3 5 3 0 1 2 0 hsa-miR-5001-5p -0.46 -0.46 N/A

BGLAP ENST00000368272.4 bone gamma-carboxyglutamate (gla) protein 82 1 0 1 0 0 hsa-miR-4498 -0.46 -0.46 N/A

PDE4D ENST00000340635.6 phosphodiesterase 4D, cAMP-specific 747 4 0 2 2 1 hsa-miR-4498 -0.46 -0.63 N/A

SCN2B ENST00000278947.5 sodium channel, voltage-gated, type II, beta subunit 5 3 1 2 0 2 hsa-miR-4498 -0.46 -0.46 N/A

C1orf180 ENST00000370624.1 chromosome 1 open reading frame 180 5 1 1 0 0 2 hsa-miR-5001-5p -0.46 -0.46 N/A

TMEM74B ENST00000381894.3 transmembrane protein 74B 33 2 1 0 1 0 hsa-miR-5001-5p -0.46 -0.46 N/A

PPARD ENST00000448077.2 peroxisome proliferator-activated receptor delta 239 4 0 2 2 2 hsa-miR-5001-5p -0.46 -0.46 N/A

FANCA ENST00000568369.1 Fanconi anemia, complementation group A 348 4 2 1 1 1 hsa-miR-5001-5p -0.46 -0.72 N/A

TLN1 ENST00000314888.9 talin 1 266 2 1 0 1 2 hsa-miR-5001-5p -0.46 -0.8 N/A

EDF1 ENST00000371649.1 endothelial differentiation-related factor 1 1288 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.55 N/A

ACOT4 ENST00000326303.4 acyl-CoA thioesterase 4 5 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.46 N/A

CASP10 ENST00000360132.3 caspase 10, apoptosis-related cysteine peptidase 55 2 1 0 1 1 hsa-miR-5001-5p -0.46 -0.6 N/A

MYH13 ENST00000418404.3 myosin, heavy chain 13, skeletal muscle 5 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.46 N/A

FGD3 ENST00000375482.3 FYVE, RhoGEF and PH domain containing 3 161 2 0 1 1 1 hsa-miR-4498 -0.46 -0.46 N/A

LTA ENST00000454783.1 lymphotoxin alpha 5 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.46 N/A

MAX ENST00000284165.6 MYC associated factor X 51 3 0 3 0 0 hsa-miR-4498 -0.46 -0.73 N/A

ZDHHC18 ENST00000374142.4 zinc finger, DHHC-type containing 18 268 5 0 3 2 1 hsa-miR-4498 -0.46 -0.66 N/A

ZG16 ENST00000400752.4 zymogen granule protein 16 23 2 1 1 0 0 hsa-miR-4498 -0.46 -0.61 N/A

CPLX3 ENST00000395018.4 complexin 3 5 2 0 2 0 0 hsa-miR-4498 -0.46 -0.46 N/A

RAD23A ENST00000586534.1 RAD23 homolog A (S. cerevisiae) 58 2 2 0 0 0 hsa-miR-5001-5p -0.46 -0.72 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NTRK2 ENST00000395882.1 neurotrophic tyrosine kinase, receptor, type 2 48 3 1 1 1 0 hsa-miR-5001-5p -0.46 -0.46 N/A

NOVA2 ENST00000263257.5 neuro-oncological ventral antigen 2 7 5 0 5 0 2 hsa-miR-4498 -0.46 -0.66 N/A

DHX34 ENST00000328771.4 DEAH (Asp-Glu-Ala-His) box polypeptide 34 469 1 1 0 0 0 hsa-miR-4498 -0.46 -0.46 N/A

CNTNAP5 ENST00000431078.1 contactin associated protein-like 5 5 2 1 1 0 0 hsa-miR-5001-5p -0.46 -0.48 N/A

OTOF ENST00000338581.6 otoferlin 5 2 0 2 0 0 hsa-miR-4498 -0.46 -0.46 N/A

NAPA ENST00000263354.3 N-ethylmaleimide-sensitive factor attachment protein, alpha 49 3 1 2 0 1 hsa-miR-4498 -0.46 -0.62 N/A

FLJ00418 ENST00000597002.1 5 2 0 1 1 0 hsa-miR-5001-5p -0.46 -0.46 N/A

ENOSF1 ENST00000383578.3 enolase superfamily member 1 95 2 1 0 1 0 hsa-miR-5001-5p -0.46 -0.54 N/A

ERG ENST00000398905.1 v-ets avian erythroblastosis virus E26 oncogene homolog 184 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.46 N/A

PIK3R5 ENST00000447110.1 phosphoinositide-3-kinase, regulatory subunit 5 5 1 1 0 0 0 hsa-miR-5001-5p -0.46 -0.46 N/A

TRIM26 ENST00000437089.1 tripartite motif containing 26 102 2 0 2 0 0 hsa-miR-4498 -0.45 -0.46 N/A

DCAF7 ENST00000310827.4 DDB1 and CUL4 associated factor 7 3289 4 1 1 2 1 hsa-miR-5001-5p -0.45 -0.46 N/A

TBX1 ENST00000332710.4 T-box 1 9 2 0 2 0 2 hsa-miR-4498 -0.45 -0.45 N/A

G6PD ENST00000393562.2 glucose-6-phosphate dehydrogenase 9 1 1 0 0 1 hsa-miR-5001-5p -0.45 -0.54 N/A

DNM1 ENST00000475805.1 dynamin 1 17 4 0 4 0 2 hsa-miR-4498 -0.45 -0.68 N/A

GAB2 ENST00000340149.2 GRB2-associated binding protein 2 627 4 0 4 0 1 hsa-miR-4498 -0.45 -0.46 N/A

MANEAL ENST00000397631.3 mannosidase, endo-alpha-like 381 2 1 1 0 0 hsa-miR-4498 -0.45 -0.61 N/A

SLC25A44 ENST00000359511.4 solute carrier family 25, member 44 760 3 0 2 1 1 hsa-miR-4498 -0.45 -0.45 N/A

ST3GAL1 ENST00000319914.5 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 59 5 1 3 1 2 hsa-miR-4498 -0.45 -1.08 N/A

PRAM1 ENST00000423345.4 PML-RARA regulated adaptor molecule 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

C19orf25 ENST00000588849.1 chromosome 19 open reading frame 25 498 2 1 0 1 3 hsa-miR-5001-5p -0.45 -0.72 N/A

VANGL2 ENST00000368061.2 VANGL planar cell polarity protein 2 560 2 0 2 0 3 hsa-miR-4498 -0.45 -0.45 N/A

SOX10 ENST00000396884.2 SRY (sex determining region Y)-box 10 5 1 0 1 0 3 hsa-miR-5001-5p -0.45 -0.45 N/A

EFNA1 ENST00000368407.3 ephrin-A1 423 2 0 2 0 0 hsa-miR-4498 -0.45 -0.45 N/A

TMPRSS3 ENST00000398405.1 transmembrane protease, serine 3 5 1 1 0 0 1 hsa-miR-5001-5p -0.45 -0.45 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score IL17A ENST00000340057.1 interleukin 17A 5 2 0 1 1 0 hsa-miR-5001-5p -0.45 -0.45 N/A

ESPN ENST00000377828.1 espin 513 3 0 3 0 4 hsa-miR-5001-5p -0.45 -0.57 N/A

RAF1 ENST00000251849.4 v-raf-1 murine leukemia viral oncogene homolog 1 2422 3 0 2 1 1 hsa-miR-5001-5p -0.45 -0.45 N/A

ZNF562 ENST00000293648.4 zinc finger protein 562 130 3 1 2 0 0 hsa-miR-4498 -0.45 -0.5 N/A

RP11-363G10.2 ENST00000375625.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

RP11-114H20.1 ENST00000375644.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

CCL1 ENST00000225842.3 chemokine (C-C motif) ligand 1 6 1 0 1 0 1 hsa-miR-5001-5p -0.45 -0.47 N/A

U2AF2 ENST00000450554.2 U2 small nuclear RNA auxiliary factor 2 1093 3 0 2 1 0 hsa-miR-4498 -0.45 -0.45 N/A

GORASP1 ENST00000319283.3 golgi reassembly stacking protein 1, 65kDa 102 2 0 1 1 1 hsa-miR-4498 -0.45 -0.45 N/A

ANKRD23 ENST00000318357.4 ankyrin repeat domain 23 9 2 1 1 0 3 hsa-miR-5001-5p -0.45 -0.45 N/A

PRR9 ENST00000368744.3 proline rich 9 5 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

CHAC1 ENST00000446533.3 ChaC, cation transport regulator homolog 1 (E. coli) 190 2 0 1 1 0 hsa-miR-4498 -0.45 -0.45 N/A

FCF1 ENST00000341162.4 FCF1 rRNA-processing protein 119 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

MAP6D1 ENST00000318631.3 MAP6 domain containing 1 45 1 1 0 0 2 hsa-miR-5001-5p -0.45 -0.45 N/A solute carrier family 6 (neutral amino acid transporter), SLC6A17 ENST00000331565.4 5 5 2 2 1 0 hsa-miR-4498 -0.45 -0.45 N/A member 17 ARL10 ENST00000310389.5 ADP-ribosylation factor-like 10 236 3 0 2 1 2 hsa-miR-4498 -0.45 -0.54 N/A

FOXI1 ENST00000449804.2 forkhead box I1 5 2 0 2 0 1 hsa-miR-4498 -0.45 -0.45 N/A

ZC3H3 ENST00000262577.5 zinc finger CCCH-type containing 3 35 1 0 1 0 1 hsa-miR-4498 -0.45 -0.45 N/A

KLF15 ENST00000296233.3 Kruppel-like factor 15 7 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

E2F4 ENST00000379378.3 E2F transcription factor 4, p107/p130-binding 1433 2 1 1 0 1 hsa-miR-4498 -0.45 -0.45 N/A

ODF3L2 ENST00000315489.4 outer dense fiber of sperm tails 3-like 2 11 1 1 0 0 1 hsa-miR-5001-5p -0.45 -0.45 N/A

PAGR1 ENST00000609618.1 PAXIP1-associated glutamate-rich protein 1 2452 1 1 0 0 3 hsa-miR-5001-5p -0.45 -0.49 N/A

ARNTL ENST00000389708.3 aryl hydrocarbon receptor nuclear translocator-like 456 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A

PITPNM2 ENST00000280562.5 phosphatidylinositol transfer protein, membrane-associated 2 66 2 0 2 0 4 hsa-miR-5001-5p -0.45 -0.49 N/A

DNAI1 ENST00000242317.4 dynein, axonemal, intermediate chain 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.45 -0.45 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TNFRSF14 ENST00000355716.4 tumor necrosis factor receptor superfamily, member 14 170 3 1 2 0 2 hsa-miR-5001-5p -0.45 -0.6 N/A

COTL1 ENST00000262428.4 coactosin-like 1 (Dictyostelium) 6558 1 1 0 0 1 hsa-miR-5001-5p -0.45 -0.45 N/A

GUCA2B ENST00000372581.1 guanylate cyclase activator 2B (uroguanylin) 5 2 0 0 2 0 hsa-miR-5001-5p -0.45 -0.45 N/A

FSTL1 ENST00000295633.3 follistatin-like 1 6788 2 0 1 1 1 hsa-miR-4498 -0.44 -0.47 N/A

CLCN7 ENST00000448525.1 chloride channel, voltage-sensitive 7 1022 2 0 2 0 1 hsa-miR-4498 -0.44 -0.44 N/A

NUBP2 ENST00000262302.9 nucleotide binding protein 2 3319 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

MGLL ENST00000434178.2 monoglyceride lipase 453 5 0 4 1 3 hsa-miR-5001-5p -0.44 -0.66 N/A

CD83 ENST00000379153.3 CD83 molecule 414 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

CLEC4G ENST00000328853.5 C-type lectin domain family 4, member G 5 1 1 0 0 0 hsa-miR-4498 -0.44 -0.44 N/A

FAM170B ENST00000311787.5 family with sequence similarity 170, member B 5 1 0 1 0 0 hsa-miR-4498 -0.44 -0.44 N/A

PPP4R1 ENST00000400556.3 protein phosphatase 4, regulatory subunit 1 665 1 1 0 0 2 hsa-miR-5001-5p -0.44 -0.5 N/A

C3orf20 ENST00000253697.3 chromosome 3 open reading frame 20 5 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

GSTM5 ENST00000369813.1 glutathione S-transferase mu 5 5 2 0 1 1 0 hsa-miR-5001-5p -0.44 -0.44 N/A

FOXRED2 ENST00000397224.4 FAD-dependent oxidoreductase domain containing 2 200 2 2 0 0 1 hsa-miR-5001-5p -0.44 -0.44 N/A

TMEM43 ENST00000306077.4 transmembrane protein 43 2575 2 1 0 1 0 hsa-miR-5001-5p -0.44 -0.47 N/A

PHLDB1 ENST00000361417.2 pleckstrin homology-like domain, family B, member 1 126 4 2 2 0 1 hsa-miR-5001-5p -0.44 -0.57 N/A

ARL6IP4 ENST00000392435.2 ADP-ribosylation-like factor 6 interacting protein 4 1797 1 1 0 0 1 hsa-miR-5001-5p -0.44 -0.48 N/A

SNX30 ENST00000374232.3 sorting nexin family member 30 33 1 1 0 0 3 hsa-miR-5001-5p -0.44 -0.49 N/A

SPSB1 ENST00000328089.6 splA/ryanodine receptor domain and SOCS box containing 1 572 1 1 0 0 1 hsa-miR-5001-5p -0.44 -0.45 N/A

CLDN19 ENST00000296387.1 claudin 19 25 2 1 1 0 2 hsa-miR-4498 -0.44 -0.77 N/A

RABGAP1L ENST00000489615.1 RAB GTPase activating protein 1-like 364 2 0 1 1 1 hsa-miR-4498 -0.44 -0.45 N/A

HDAC11 ENST00000433119.1 histone deacetylase 11 443 1 1 0 0 4 hsa-miR-5001-5p -0.44 -0.44 N/A

ZNF418 ENST00000595830.1 zinc finger protein 418 8 1 1 0 0 0 hsa-miR-4498 -0.44 -0.44 N/A

BCAS1 ENST00000371440.3 breast carcinoma amplified sequence 1 0 2 1 1 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

KIAA0087 ENST00000242109.3 KIAA0087 5 1 1 0 0 1 hsa-miR-4498 -0.44 -0.44 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score UBAP1 ENST00000545103.1 ubiquitin associated protein 1 357 1 1 0 0 1 hsa-miR-5001-5p -0.44 -0.44 N/A

CYGB ENST00000293230.5 cytoglobin 10 2 0 2 0 2 hsa-miR-4498 -0.44 -0.44 N/A

WNT2B ENST00000369686.5 wingless-type MMTV integration site family, member 2B 5 4 0 4 0 2 hsa-miR-4498 -0.44 -0.44 N/A tetratricopeptide repeat, ankyrin repeat and coiled-coil TANC2 ENST00000424789.2 155 2 0 1 1 2 hsa-miR-4498 -0.44 -0.44 N/A containing 2 TET3 ENST00000409262.3 tet methylcytosine dioxygenase 3 1437 4 1 2 1 0 hsa-miR-5001-5p -0.44 -0.44 N/A CTD (carboxy-terminal domain, RNA polymerase II, CTDSP1 ENST00000273062.2 1299 3 0 3 0 1 hsa-miR-4498 -0.44 -0.44 N/A polypeptide A) small phosphatase 1 HOXC9 ENST00000303450.4 homeobox C9 248 1 1 0 0 1 hsa-miR-5001-5p -0.44 -0.53 N/A

AC013269.5 ENST00000409259.1 Uncharacterized protein 5 2 0 2 0 1 hsa-miR-4498 -0.44 -0.44 N/A

MPZ ENST00000533357.1 myelin protein zero 17 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

IRF4 ENST00000380956.4 interferon regulatory factor 4 10 1 1 0 0 1 hsa-miR-5001-5p -0.44 -0.44 N/A

MMP25 ENST00000336577.4 matrix metallopeptidase 25 5 1 1 0 0 2 hsa-miR-5001-5p -0.44 -0.44 N/A

IPO4 ENST00000354464.6 importin 4 811 2 0 1 1 0 hsa-miR-4498 -0.44 -0.44 N/A

RTEL1 ENST00000370018.3 regulator of telomere elongation helicase 1 325 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

C10orf54 ENST00000394957.3 chromosome 10 open reading frame 54 78 7 1 4 2 1 hsa-miR-4498 -0.44 -0.79 N/A UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- GALNT10 ENST00000297107.6 3445 3 0 2 1 2 hsa-miR-5001-5p -0.44 -0.44 N/A acetylgalactosaminyltransferase 10 (GalNAc-T10) core-binding factor, runt domain, alpha subunit 2; CBFA2T3 ENST00000327483.5 7 2 0 2 0 3 hsa-miR-5001-5p -0.44 -0.68 N/A translocated to, 3 PLXNB3 ENST00000538966.1 plexin B3 22 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

KMT2B ENST00000420124.1 Histone-lysine N-methyltransferase 2B 1005 1 1 0 0 0 hsa-miR-5001-5p -0.44 -0.44 N/A

SARM1 ENST00000457710.3 sterile alpha and TIR motif containing 1 130 7 1 6 0 2 hsa-miR-4498 -0.43 -0.55 N/A

CLDN18 ENST00000343735.4 claudin 18 5 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

RP11-758M4.1 ENST00000523118.1 Uncharacterized protein 5 2 0 0 2 0 hsa-miR-5001-5p -0.43 -0.43 N/A

KXD1 ENST00000540691.1 KxDL motif containing 1 117 1 1 0 0 1 hsa-miR-5001-5p -0.43 -0.43 N/A

PPIF ENST00000394579.3 peptidylprolyl isomerase F 9304 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

CAPN15 ENST00000219611.2 calpain 15 5 4 1 3 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

TCF7L2 ENST00000369386.1 transcription factor 7-like 2 (T-cell specific, HMG-box) 650 2 0 1 1 1 hsa-miR-5001-5p -0.43 -0.43 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ACSS2 ENST00000336325.4 acyl-CoA synthetase short-chain family member 2 4548 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

KIAA1045 ENST00000242315.3 KIAA1045 42 3 0 1 2 5 hsa-miR-5001-5p -0.43 -0.53 N/A

ESPNL ENST00000343063.3 espin-like 26 2 1 1 0 1 hsa-miR-5001-5p -0.43 -0.43 N/A

ABCF1 ENST00000326195.8 ATP-binding cassette, sub-family F (GCN20), member 1 1078 1 1 0 0 0 hsa-miR-4498 -0.43 -0.43 N/A

FAM211A ENST00000409083.3 family with sequence similarity 211, member A 23 2 0 2 0 1 hsa-miR-4498 -0.43 -0.48 N/A

MBD3 ENST00000590550.2 methyl-CpG binding domain protein 3 393 6 1 4 1 5 hsa-miR-5001-5p -0.43 -1.25 N/A

CCNF ENST00000397066.4 cyclin F 1432 4 0 2 2 0 hsa-miR-5001-5p -0.43 -0.44 N/A

HES2 ENST00000377834.4 hairy and enhancer of split 2 (Drosophila) 5 2 1 1 0 0 hsa-miR-4498 -0.43 -0.43 N/A

FAM86A ENST00000458008.4 family with sequence similarity 86, member A 5 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

ISM2 ENST00000493585.1 isthmin 2 7 2 2 0 0 2 hsa-miR-5001-5p -0.43 -0.62 N/A

HLA-DOA ENST00000229829.5 major histocompatibility complex, class II, DO alpha 7 1 0 1 0 2 hsa-miR-4498 -0.43 -0.43 N/A sepiapterin reductase (7,8-dihydrobiopterin:NADP+ SPR ENST00000234454.5 554 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A oxidoreductase) RASD2 ENST00000216127.4 RASD family, member 2 10 2 0 2 0 1 hsa-miR-4498 -0.43 -0.43 N/A transient receptor potential cation channel, subfamily V, TRPV6 ENST00000359396.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A member 6 E2F2 ENST00000361729.2 E2F transcription factor 2 96 1 0 1 0 4 hsa-miR-5001-5p -0.43 -0.51 N/A

PCTP ENST00000576183.1 phosphatidylcholine transfer protein 476 1 1 0 0 0 hsa-miR-4498 -0.43 -0.47 N/A

NGB ENST00000298352.4 neuroglobin 5 1 0 1 0 1 hsa-miR-5001-5p -0.43 -0.43 N/A

CCDC13 ENST00000310232.6 coiled-coil domain containing 13 5 3 1 0 2 1 hsa-miR-5001-5p -0.43 -0.43 N/A

AC132192.1 ENST00000596206.1 LOC644656 protein; Uncharacterized protein 11 1 0 1 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

WBP2 ENST00000254806.3 WW domain binding protein 2 362 2 0 2 0 1 hsa-miR-4498 -0.43 -0.43 N/A

ASIC1 ENST00000228468.4 acid-sensing (proton-gated) ion channel 1 111 3 0 2 1 2 hsa-miR-4498 -0.43 -0.46 N/A TEA domain family member 1 (SV40 transcriptional TEAD1 ENST00000361905.4 740 4 0 2 2 1 hsa-miR-5001-5p -0.43 -0.44 N/A enhancer factor) ILDR1 ENST00000273691.3 immunoglobulin-like domain containing receptor 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

BIN3 ENST00000276416.6 bridging integrator 3 364 2 0 1 1 2 hsa-miR-5001-5p -0.43 -0.57 N/A

KPNA6 ENST00000373625.3 karyopherin alpha 6 (importin alpha 7) 272 3 1 2 0 1 hsa-miR-4498 -0.43 -0.55 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM97 ENST00000226230.6 transmembrane protein 97 10226 2 1 0 1 0 hsa-miR-5001-5p -0.43 -0.43 N/A

C11orf82 ENST00000528759.1 chromosome 11 open reading frame 82 579 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

PMFBP1 ENST00000537465.1 polyamine modulated factor 1 binding protein 1 5 2 0 2 0 0 hsa-miR-4498 -0.43 -0.43 N/A

THPO ENST00000421442.2 thrombopoietin 208 1 0 1 0 0 hsa-miR-4498 -0.43 -0.43 N/A

ANKRD24 ENST00000600132.1 ankyrin repeat domain 24 7 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

POU2F1 ENST00000367866.2 POU class 2 homeobox 1 83 2 0 1 1 0 hsa-miR-4498 -0.43 -0.46 N/A

CIAO1 ENST00000488633.1 cytosolic iron-sulfur protein assembly 1 1143 2 1 1 0 0 hsa-miR-4498 -0.43 -0.6 N/A

FFAR2 ENST00000599180.2 free fatty acid receptor 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

IRF2BP1 ENST00000302165.3 interferon regulatory factor 2 binding protein 1 30 1 1 0 0 0 hsa-miR-5001-5p -0.43 -0.43 N/A

ABCF2 ENST00000287844.2 ATP-binding cassette, sub-family F (GCN20), member 2 48 3 2 1 0 0 hsa-miR-4498 -0.43 -0.74 N/A

CSNK1G1 ENST00000303052.7 casein kinase 1, gamma 1 149 2 1 1 0 2 hsa-miR-4498 -0.42 -0.42 N/A

TGFA ENST00000295400.6 transforming growth factor, alpha 36 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

JDP2 ENST00000435893.2 Jun dimerization protein 2 110 2 0 2 0 1 hsa-miR-4498 -0.42 -0.42 N/A

IL17C ENST00000244241.4 interleukin 17C 5 1 0 1 0 1 hsa-miR-4498 -0.42 -0.42 N/A calcium channel, voltage-dependent, R type, alpha 1E CACNA1E ENST00000526775.1 5 3 1 0 2 4 hsa-miR-5001-5p -0.42 -0.42 N/A subunit RP11-242G20.1 ENST00000434931.2 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.42 -0.42 N/A

GLI3 ENST00000395925.3 GLI family zinc finger 3 544 2 1 0 1 1 hsa-miR-5001-5p -0.42 -0.45 N/A

LZTS2 ENST00000370223.3 leucine zipper, putative tumor suppressor 2 10 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

POLL ENST00000370168.3 polymerase (DNA directed), lambda 139 5 1 2 2 0 hsa-miR-5001-5p -0.42 -0.99 N/A

CASP14 ENST00000427043.3 caspase 14, apoptosis-related cysteine peptidase 5 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

C19orf60 ENST00000358607.6 chromosome 19 open reading frame 60 695 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

SLC30A3 ENST00000233535.4 solute carrier family 30 (zinc transporter), member 3 5 2 0 2 0 2 hsa-miR-4498 -0.42 -0.42 N/A

FAM182B ENST00000376403.1 family with sequence similarity 182, member B 9 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

FAM104A ENST00000581110.1 family with sequence similarity 104, member A 2724 1 0 1 0 1 hsa-miR-4498 -0.42 -0.42 N/A

P2RX6 ENST00000402329.3 purinergic receptor P2X, ligand-gated ion channel, 6 10 1 1 0 0 1 hsa-miR-5001-5p -0.42 -0.42 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TFE3 ENST00000315869.7 transcription factor binding to IGHM enhancer 3 20 4 1 2 1 1 hsa-miR-5001-5p -0.42 -0.42 N/A

CYS1 ENST00000381813.4 cystin 1 22 2 1 1 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

NPY ENST00000242152.2 neuropeptide Y 111 1 0 0 1 0 hsa-miR-5001-5p -0.42 -0.42 N/A

BOK ENST00000318407.3 BCL2-related ovarian killer 588 3 0 3 0 0 hsa-miR-4498 -0.42 -0.42 N/A

DMBX1 ENST00000360032.3 diencephalon/mesencephalon homeobox 1 31 2 1 1 0 0 hsa-miR-5001-5p -0.42 -0.47 N/A

MED24 ENST00000394126.1 mediator complex subunit 24 1064 1 1 0 0 1 hsa-miR-5001-5p -0.42 -0.42 N/A UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, B3GALT4 ENST00000451237.1 13 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A polypeptide 4 EXOSC2 ENST00000372358.5 exosome component 2 852 3 2 1 0 0 hsa-miR-5001-5p -0.42 -0.73 N/A

IGLL5 ENST00000532223.2 immunoglobulin lambda-like polypeptide 5 5 1 0 1 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

ZNF671 ENST00000317398.6 zinc finger protein 671 35 2 0 0 2 0 hsa-miR-5001-5p -0.42 -0.42 N/A

TMEM216 ENST00000334888.5 transmembrane protein 216 616 3 1 0 2 0 hsa-miR-5001-5p -0.42 -0.74 N/A solute carrier family 36 (proton/amino acid symporter), SLC36A1 ENST00000243389.3 236 4 1 0 3 0 hsa-miR-5001-5p -0.42 -0.42 N/A member 1 METAP1D ENST00000315796.4 methionyl aminopeptidase type 1D (mitochondrial) 86 3 0 3 0 0 hsa-miR-5001-5p -0.42 -0.55 N/A

TRIM41 ENST00000315073.5 tripartite motif containing 41 494 2 0 2 0 0 hsa-miR-4498 -0.42 -0.42 N/A

SUFU ENST00000369902.3 suppressor of fused homolog (Drosophila) 247 3 1 0 2 3 hsa-miR-5001-5p -0.42 -0.56 N/A

CPNE5 ENST00000244751.2 copine V 13 3 0 2 1 1 hsa-miR-4498 -0.42 -0.42 N/A

PAK6 ENST00000260404.4 p21 protein (Cdc42/Rac)-activated kinase 6 70 2 0 1 1 1 hsa-miR-5001-5p -0.42 -0.42 N/A

TMEM127 ENST00000258439.3 transmembrane protein 127 296 5 0 3 2 1 hsa-miR-5001-5p -0.42 -0.56 N/A

NUDT3 ENST00000607016.1 nudix (nucleoside diphosphate linked moiety X)-type motif 3 190 5 2 1 2 1 hsa-miR-5001-5p -0.42 -1.31 N/A

EPB41L2 ENST00000531410.1 erythrocyte membrane protein band 4.1-like 2 353 1 1 0 0 0 hsa-miR-5001-5p -0.42 -0.42 N/A

PRKAR2A ENST00000265563.8 protein kinase, cAMP-dependent, regulatory, type II, alpha 583 2 1 1 0 0 hsa-miR-4498 -0.42 -0.42 N/A

RNASEK ENST00000548577.1 ribonuclease, RNase K 4671 1 0 1 0 1 hsa-miR-5001-5p -0.42 -0.49 N/A

PRRT4 ENST00000489835.2 proline-rich transmembrane protein 4 5 1 0 1 0 1 hsa-miR-5001-5p -0.41 -0.41 N/A

MS4A15 ENST00000337911.4 membrane-spanning 4-domains, subfamily A, member 15 5 2 1 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A

FAM227A ENST00000535113.1 family with sequence similarity 227, member A 16 2 0 1 1 1 hsa-miR-5001-5p -0.41 -0.63 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZBTB41 ENST00000367405.4 zinc finger and BTB domain containing 41 33 2 0 2 0 1 hsa-miR-5001-5p -0.41 -0.46 N/A

RAB30 ENST00000533486.1 RAB30, member RAS oncogene family 274 2 0 1 1 0 hsa-miR-4498 -0.41 -0.43 N/A

HLA-E ENST00000376630.4 major histocompatibility complex, class I, E 1858 1 1 0 0 0 hsa-miR-5001-5p -0.41 -0.43 N/A

LMO2 ENST00000395833.3 LIM domain only 2 (rhombotin-like 1) 8 2 0 1 1 0 hsa-miR-4498 -0.41 -0.41 N/A

SYT7 ENST00000263846.4 synaptotagmin VII 192 5 1 4 0 2 hsa-miR-4498 -0.41 -0.94 N/A

MTA3 ENST00000405592.1 metastasis associated 1 family, member 3 194 2 1 0 1 3 hsa-miR-4498 -0.41 -0.43 N/A

CTRC ENST00000375943.2 chymotrypsin C (caldecrin) 5 2 1 1 0 1 hsa-miR-4498 -0.41 -0.41 N/A

KSR2 ENST00000425217.1 kinase suppressor of ras 2 22 4 0 4 0 6 hsa-miR-4498 -0.41 -0.41 N/A

NGFR ENST00000172229.3 nerve growth factor receptor 5 4 1 2 1 3 hsa-miR-5001-5p -0.41 -0.41 N/A

MESDC1 ENST00000267984.2 mesoderm development candidate 1 84 3 0 3 0 0 hsa-miR-4498 -0.41 -0.6 N/A

P4HA2 ENST00000401867.1 prolyl 4-hydroxylase, alpha polypeptide II 1077 3 0 2 1 0 hsa-miR-5001-5p -0.41 -0.54 N/A

TEN1 ENST00000588202.1 TEN1 CST complex subunit 413 1 0 1 0 1 hsa-miR-4498 -0.41 -0.41 N/A

NCSTN ENST00000294785.5 nicastrin 578 1 1 0 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

C9orf62 ENST00000320778.2 chromosome 9 open reading frame 62 5 2 1 1 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

FGF1 ENST00000360966.5 fibroblast growth factor 1 (acidic) 88 2 1 0 1 0 hsa-miR-5001-5p -0.41 -0.72 N/A

RCVRN ENST00000226193.5 recoverin 5 1 1 0 0 1 hsa-miR-5001-5p -0.41 -0.41 N/A

C5orf20 ENST00000503143.2 chromosome 5 open reading frame 20 5 2 1 1 0 1 hsa-miR-4498 -0.41 -0.41 N/A solute carrier family 35 (UDP-xylose/UDP-N- SLC35B4 ENST00000378509.4 899 4 0 3 1 1 hsa-miR-5001-5p -0.41 -0.45 N/A acetylglucosamine transporter), member B4 NR5A1 ENST00000373588.4 nuclear receptor subfamily 5, group A, member 1 5 3 0 3 0 2 hsa-miR-4498 -0.41 -0.41 N/A

C22orf26 ENST00000396008.2 chromosome 22 open reading frame 26 5 2 0 2 0 0 hsa-miR-4498 -0.41 -0.41 N/A

SON ENST00000290239.6 SON DNA binding protein 161 2 1 1 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

TSPAN18 ENST00000340160.3 tetraspanin 18 332 2 0 0 2 1 hsa-miR-5001-5p -0.41 -0.52 N/A

AKR1E2 ENST00000298375.7 aldo-keto reductase family 1, member E2 5 3* 0 1 1 0 hsa-miR-4498 -0.41 -0.41 N/A Fc fragment of IgE, high affinity I, receptor for; gamma FCER1G ENST00000289902.1 99 1 0 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A polypeptide NT5C1A ENST00000235628.1 5'-nucleotidase, cytosolic IA 4 5 0 3 2 3 hsa-miR-5001-5p -0.41 -0.41 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score eukaryotic translation initiation factor 2, subunit 3 gamma, EIF2S3 ENST00000253039.4 1571 2 1 0 1 0 hsa-miR-5001-5p -0.41 -0.43 N/A 52kDa ST3GAL3 ENST00000372377.4 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 135 2 0 2 0 0 hsa-miR-4498 -0.41 -0.41 N/A

ACP2 ENST00000256997.3 acid phosphatase 2, lysosomal 235 1 1 0 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

MYRF ENST00000278836.5 myelin regulatory factor 131 3 0 3 0 3 hsa-miR-4498 -0.41 -0.41 N/A

GPR97 ENST00000333493.4 G protein-coupled receptor 97 8 1 1 0 0 1 hsa-miR-5001-5p -0.41 -0.41 N/A

DHPS ENST00000210060.7 deoxyhypusine synthase 10521 1 0 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A solute carrier family 12 (potassium/chloride transporter), SLC12A7 ENST00000264930.5 149 2 1 0 1 3 hsa-miR-5001-5p -0.41 -0.41 N/A member 7 PMF1 ENST00000567140.1 polyamine-modulated factor 1 77 1 0 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A

L1CAM ENST00000370060.1 L1 cell adhesion molecule 439 2 2 0 0 1 hsa-miR-5001-5p -0.41 -0.41 N/A

KLK12 ENST00000529888.1 kallikrein-related peptidase 12 5 1 0 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A

PTPRN ENST00000409251.3 protein tyrosine phosphatase, receptor type, N 387 1 0 0 1 2 hsa-miR-4498 -0.41 -0.41 N/A

GPR113 ENST00000421160.2 G protein-coupled receptor 113 5 1 1 0 0 1 hsa-miR-5001-5p -0.41 -0.41 N/A

GRB2 ENST00000392563.1 growth factor receptor-bound protein 2 2660 1 1 0 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

HLA-DRA ENST00000395388.2 major histocompatibility complex, class II, DR alpha 58 1 0 1 0 0 hsa-miR-4498 -0.41 -0.41 N/A

VGF ENST00000249330.2 VGF nerve growth factor inducible 16 2 1 1 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

PLAC9 ENST00000372263.3 placenta-specific 9 7 1 0 1 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

DDX19A ENST00000302243.7 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 148 2 0 2 0 0 hsa-miR-5001-5p -0.41 -0.41 N/A

SMCR8 ENST00000406438.3 Smith-Magenis syndrome chromosome region, candidate 8 219 1 0 0 1 3 hsa-miR-5001-5p -0.4 -0.42 N/A

RND2 ENST00000544533.1 Rho family GTPase 2 26 4 1 2 1 0 hsa-miR-4498 -0.4 -0.86 N/A

CALM3 ENST00000291295.9 calmodulin 3 (phosphorylase kinase, delta) 3982 3 0 3 0 0 hsa-miR-4498 -0.4 -0.67 N/A

IQGAP1 ENST00000268182.5 IQ motif containing GTPase activating protein 1 5523 2 1 0 1 0 hsa-miR-5001-5p -0.4 -0.42 N/A

AIPL1 ENST00000381129.3 aryl hydrocarbon receptor interacting protein-like 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

SLC4A1 ENST00000262418.6 solute carrier family 4 (anion exchanger), member 1 5 2 1 1 0 0 hsa-miR-4498 -0.4 -0.4 N/A

TTYH3 ENST00000258796.7 tweety family member 3 188 7 0 6 1 5 hsa-miR-5001-5p -0.4 -0.4 N/A phospholysine phosphohistidine inorganic pyrophosphate LHPP ENST00000368839.1 2365 4 0 3 1 4 hsa-miR-5001-5p -0.4 -0.62 N/A phosphatase Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ACVR1B ENST00000257963.4 activin A receptor, type IB 3319 3 2 1 0 1 hsa-miR-5001-5p -0.4 -0.4 N/A

IRF2 ENST00000393593.3 interferon regulatory factor 2 420 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

C3orf56 ENST00000398112.1 chromosome 3 open reading frame 56 5 1 1 0 0 0 hsa-miR-4498 -0.4 -0.4 N/A

LRRC16B ENST00000342740.5 leucine rich repeat containing 16B 5 1 0 1 0 1 hsa-miR-4498 -0.4 -0.4 N/A

MAPK3 ENST00000403394.1 mitogen-activated protein kinase 3 271 3 0 2 1 0 hsa-miR-5001-5p -0.4 -0.4 N/A

MFN2 ENST00000444836.1 mitofusin 2 1096 4 0 1 3 0 hsa-miR-4498 -0.4 -0.4 N/A

LYPD1 ENST00000397463.2 LY6/PLAUR domain containing 1 347 1 0 1 0 1 hsa-miR-4498 -0.4 -0.4 N/A required for meiotic nuclear division 5 homolog B (S. RMND5B ENST00000515098.1 959 3 3 0 0 2 hsa-miR-5001-5p -0.4 -0.71 N/A cerevisiae) PSMC3IP ENST00000393795.3 PSMC3 interacting protein 42 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.48 N/A

SPOP ENST00000393328.2 speckle-type POZ protein 883 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.41 N/A

SPRED3 ENST00000587013.1 sprouty-related, EVH1 domain containing 3 42 3 1 1 1 3 hsa-miR-5001-5p -0.4 -0.47 N/A

TMEM79 ENST00000295694.5 transmembrane protein 79 11 2 2 0 0 0 hsa-miR-5001-5p -0.4 -0.85 N/A

CCL24 ENST00000222902.2 chemokine (C-C motif) ligand 24 5 1 0 1 0 0 hsa-miR-4498 -0.4 -0.4 N/A BRCA1 associated protein-1 (ubiquitin carboxy-terminal BAP1 ENST00000460680.1 445 2 0 1 1 2 hsa-miR-5001-5p -0.4 -0.41 N/A hydrolase) NCOR1 ENST00000268712.3 nuclear receptor corepressor 1 268 3 1 0 2 0 hsa-miR-5001-5p -0.4 -0.52 N/A

TBC1D3C ENST00000308078.7 TBC1 domain family, member 3C 5 2 0 2 0 0 hsa-miR-4498 -0.4 -0.4 N/A

PAX2 ENST00000370296.2 paired box 2 8 4 0 4 0 3 hsa-miR-5001-5p -0.4 -0.4 N/A

MUC3A ENST00000319509.7 mucin 3A, cell surface associated 20 3 0 2 1 3 hsa-miR-4498 -0.4 -0.46 N/A

NAALADL1 ENST00000339885.2 N-acetylated alpha-linked acidic dipeptidase-like 1 5 2 0 1 1 4 hsa-miR-5001-5p -0.4 -0.4 N/A

COPS7B ENST00000373608.3 COP9 signalosome subunit 7B 331 2 0 2 0 1 hsa-miR-4498 -0.4 -0.43 N/A

HDGF ENST00000357325.5 hepatoma-derived growth factor 10112 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

TNFSF8 ENST00000223795.2 tumor necrosis factor (ligand) superfamily, member 8 5 2 1 1 0 2 hsa-miR-5001-5p -0.4 -0.51 N/A

SCXA ENST00000340695.2 scleraxis homolog A (mouse) 5 1 0 1 0 1 hsa-miR-4498 -0.4 -0.4 N/A

C10orf111 ENST00000378207.3 chromosome 10 open reading frame 111 5 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

SEC24D ENST00000429811.2 SEC24 family, member D (S. cerevisiae) 50 2 0 1 1 0 hsa-miR-4498 -0.4 -0.4 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NAT6 ENST00000354862.4 N-acetyltransferase 6 (GCN5-related) 29 1 0 0 1 1 hsa-miR-5001-5p -0.4 -0.4 N/A

SCXB ENST00000340210.1 scleraxis homolog B (mouse) 0 1 0 1 0 1 hsa-miR-4498 -0.4 -0.4 N/A

HMOX2 ENST00000570646.1 heme oxygenase (decycling) 2 437 1 0 1 0 1 hsa-miR-4498 -0.4 -0.44 N/A

COX8A ENST00000314133.3 cytochrome c oxidase subunit VIIIA (ubiquitous) 1211 1 0 1 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

NECAB3 ENST00000246190.6 N-terminal EF-hand calcium binding protein 3 154 5 2 2 1 1 hsa-miR-5001-5p -0.4 -0.53 N/A

C2orf91 ENST00000378711.2 chromosome 2 open reading frame 91 5 1 1 0 0 1 hsa-miR-5001-5p -0.4 -0.4 N/A

SH3RF2 ENST00000511217.1 SH3 domain containing ring finger 2 53 2 0 2 0 0 hsa-miR-4498 -0.4 -0.4 N/A

AGPAT2 ENST00000371694.3 1-acylglycerol-3-phosphate O-acyltransferase 2 303 1 1 0 0 1 hsa-miR-5001-5p -0.4 -0.4 N/A

BOC ENST00000485230.1 BOC cell adhesion associated, oncogene regulated 159 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

JPH3 ENST00000284262.2 junctophilin 3 318 3 0 2 1 3 hsa-miR-5001-5p -0.4 -0.4 N/A

CDC14B ENST00000265659.2 cell division cycle 14B 2 3 1 0 2 4 hsa-miR-5001-5p -0.4 -0.4 N/A potassium voltage-gated channel, shaker-related subfamily, KCNA3 ENST00000369769.2 5 2 0 2 0 0 hsa-miR-4498 -0.4 -0.4 N/A member 3 RAB11B ENST00000328024.6 RAB11B, member RAS oncogene family 920 3 1 2 0 0 hsa-miR-4498 -0.4 -0.57 N/A

NOC4L ENST00000538784.1 nucleolar complex associated 4 homolog (S. cerevisiae) 548 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.99 N/A

C15orf39 ENST00000567617.1 chromosome 15 open reading frame 39 1023 3 1 1 1 0 hsa-miR-5001-5p -0.4 -0.43 N/A

GLP2R ENST00000262441.5 glucagon-like peptide 2 receptor 247 3 0 2 1 0 hsa-miR-4498 -0.4 -0.41 N/A

HIPK2 ENST00000406875.3 homeodomain interacting protein kinase 2 48 4 0 4 0 5 hsa-miR-4498 -0.4 -0.4 N/A

CBLN3 ENST00000267406.6 cerebellin 3 precursor 30 1 0 1 0 1 hsa-miR-4498 -0.4 -0.4 N/A

PRELP ENST00000343110.2 proline/arginine-rich end leucine-rich repeat protein 5 2 0 2 0 5 hsa-miR-4498 -0.4 -0.4 N/A

ANKRD34A ENST00000323397.4 ankyrin repeat domain 34A 6 1 1 0 0 0 hsa-miR-5001-5p -0.4 -0.4 N/A

NPEPL1 ENST00000356091.6 aminopeptidase-like 1 134 2 1 1 0 0 hsa-miR-4498 -0.39 -0.54 N/A

AC022532.1 ENST00000420338.2 Uncharacterized protein 15 2 0 1 1 0 hsa-miR-5001-5p -0.39 -0.49 N/A

C12orf52 ENST00000548278.1 chromosome 12 open reading frame 52 1319 3 0 1 2 1 hsa-miR-4498 -0.39 -0.63 N/A

KIAA1522 ENST00000401073.2 KIAA1522 13 1 0 0 1 1 hsa-miR-5001-5p -0.39 -0.39 N/A

SCAMP5 ENST00000425597.3 secretory carrier membrane protein 5 127 2 0 2 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TCF23 ENST00000296096.5 transcription factor 23 5 5 0 5 0 1 hsa-miR-4498 -0.39 -0.98 N/A

CDC25B ENST00000245960.5 cell division cycle 25B 3358 2 1 1 0 0 hsa-miR-5001-5p -0.39 -0.4 N/A

COX19 ENST00000344111.3 cytochrome c oxidase assembly homolog 19 (S. cerevisiae) 734 2 0 1 1 1 hsa-miR-5001-5p -0.39 -0.45 N/A

WNT3A ENST00000284523.1 wingless-type MMTV integration site family, member 3A 7 4 0 3 1 2 hsa-miR-5001-5p -0.39 -0.39 N/A

AAK1 ENST00000409085.4 AP2 associated kinase 1 27 4 2 1 1 1 hsa-miR-4498 -0.39 -0.81 N/A

SLC38A5 ENST00000376876.3 solute carrier family 38, member 5 27 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

VDR ENST00000395324.2 vitamin D (1,25- dihydroxyvitamin D3) receptor 416 3 2 1 0 3 hsa-miR-5001-5p -0.39 -0.39 N/A RFNG O-fucosylpeptide 3-beta-N- RFNG ENST00000310496.4 242 3 0 2 1 1 hsa-miR-4498 -0.39 -0.48 N/A acetylglucosaminyltransferase FXYD1 ENST00000588081.1 FXYD domain containing ion transport regulator 1 14 1 0 1 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

TREML1 ENST00000373127.4 triggering receptor expressed on myeloid cells-like 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

NAB2 ENST00000357680.4 NGFI-A binding protein 2 (EGR1 binding protein 2) 4262 1 1 0 0 1 hsa-miR-5001-5p -0.39 -0.39 N/A

PMF1-BGLAP ENST00000490491.1 PMF1-BGLAP readthrough 82 1 0 1 0 0 hsa-miR-4498 -0.39 -0.39 N/A

NKAIN1 ENST00000373736.2 Na+/K+ transporting ATPase interacting 1 10 2 0 2 0 2 hsa-miR-4498 -0.39 -0.39 N/A

AC074389.6 ENST00000382528.1 LOC401296 protein; Uncharacterized protein 5 1 1 0 0 1 hsa-miR-5001-5p -0.39 -0.39 N/A

PTPN14 ENST00000366956.5 protein tyrosine phosphatase, non-receptor type 14 301 2 0 0 2 1 hsa-miR-5001-5p -0.39 -0.44 N/A HCG20425, isoform CRA_a; Uncharacterized protein; RP4-758J18.2 ENST00000444362.1 283 1 1 0 0 2 hsa-miR-4498 -0.39 -0.39 N/A cDNA FLJ53815 AC074091.13 ENST00000379677.2 Uncharacterized protein 5 2 0 1 1 1 hsa-miR-4498 -0.39 -0.39 N/A

TMEM63C ENST00000298351.4 transmembrane protein 63C 13 4 0 2 2 3 hsa-miR-4498 -0.39 -0.39 N/A

GSTM4 ENST00000369833.1 glutathione S-transferase mu 4 767 2 0 1 1 2 hsa-miR-4498 -0.39 -0.39 N/A

HOXC6 ENST00000243108.4 homeobox C6 63 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

DND1 ENST00000542735.1 DND microRNA-mediated repression inhibitor 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

KATNB1 ENST00000379661.3 katanin p80 (WD repeat containing) subunit B 1 949 1 0 0 1 2 hsa-miR-5001-5p -0.39 -0.39 N/A

CNOT1 ENST00000317147.5 CCR4-NOT transcription complex, subunit 1 294 2 0 2 0 1 hsa-miR-4498 -0.39 -0.66 N/A

AC016559.1 ENST00000594347.1 Uncharacterized protein 15 1 0 1 0 0 hsa-miR-4498 -0.39 -0.39 N/A

BANF1 ENST00000312175.2 barrier to autointegration factor 1 148 1 0 1 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score nuclear factor of kappa light polypeptide gene enhancer in NFKB2 ENST00000369966.3 364 1 0 1 0 0 hsa-miR-4498 -0.39 -0.39 N/A B-cells 2 (p49/p100) CALN1 ENST00000329008.5 calneuron 1 5 3 0 2 1 2 hsa-miR-4498 -0.39 -0.39 N/A

AL133373.1 ENST00000596306.1 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.39 -0.39 N/A

SUDS3 ENST00000397564.2 suppressor of defective silencing 3 homolog (S. cerevisiae) 224 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.46 N/A

THY1 ENST00000284240.5 Thy-1 cell surface antigen 2345 2 0 2 0 3 hsa-miR-5001-5p -0.39 -0.43 N/A

ZNRF3 ENST00000544604.2 zinc and ring finger 3 179 2 1 1 0 3 hsa-miR-5001-5p -0.39 -0.48 N/A

ARFGAP2 ENST00000426335.2 ADP-ribosylation factor GTPase activating protein 2 3549 2 0 2 0 0 hsa-miR-4498 -0.39 -0.39 N/A

TRIP13 ENST00000166345.3 thyroid hormone receptor interactor 13 3078 2 2 0 0 0 hsa-miR-4498 -0.39 -0.72 N/A solute carrier family 2 (facilitated glucose transporter), SLC2A1 ENST00000426263.3 13928 1 0 1 0 1 hsa-miR-5001-5p -0.39 -0.39 N/A member 1 MIA ENST00000594436.1 melanoma inhibitory activity 14 1 0 0 1 0 hsa-miR-5001-5p -0.39 -0.39 N/A

C11orf72 ENST00000333139.3 chromosome 11 open reading frame 72 5 2 0 2 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

AIM1 ENST00000369066.3 absent in melanoma 1 35 1 1 0 0 0 hsa-miR-5001-5p -0.39 -0.39 N/A

PYGB ENST00000216962.4 phosphorylase, glycogen; brain 1761 3 0 2 1 1 hsa-miR-5001-5p -0.39 -0.39 N/A

COL8A2 ENST00000303143.4 collagen, type VIII, alpha 2 15 2 0 1 1 3 hsa-miR-5001-5p -0.39 -0.39 N/A

TENM1 ENST00000371130.3 teneurin transmembrane protein 1 5 2 0 1 1 0 hsa-miR-5001-5p -0.39 -0.39 N/A

BGN ENST00000331595.4 biglycan 174 2 0 2 0 1 hsa-miR-4498 -0.39 -0.39 N/A Protein LOC100506667; Putative uncharacterized protein DKFZP434H0512 ENST00000600140.1 5 2 0 0 2 1 hsa-miR-5001-5p -0.39 -0.39 N/A DKFZp434H0512 CLCN2 ENST00000423355.2 chloride channel, voltage-sensitive 2 44 3 0 2 1 3 hsa-miR-5001-5p -0.38 -0.39 N/A

YIF1A ENST00000471387.2 Yip1 interacting factor homolog A (S. cerevisiae) 211 1 0 1 0 0 hsa-miR-4498 -0.38 -0.39 N/A

AGPAT3 ENST00000291572.8 1-acylglycerol-3-phosphate O-acyltransferase 3 2443 3 0 2 1 3 hsa-miR-4498 -0.38 -0.41 N/A

CDPF1 ENST00000404744.1 cysteine-rich, DPF motif domain containing 1 169 2 0 1 1 1 hsa-miR-5001-5p -0.38 -0.38 N/A

C1orf145 ENST00000295012.5 chromosome 1 open reading frame 145 5 1 0 1 0 0 hsa-miR-4498 -0.38 -0.38 N/A

PHF19 ENST00000373896.3 PHD finger protein 19 490 3 0 0 3 1 hsa-miR-5001-5p -0.38 -0.38 N/A

KCNIP1 ENST00000328939.4 Kv channel interacting protein 1 5 1 1 0 0 0 hsa-miR-4498 -0.38 -0.38 N/A

IGDCC3 ENST00000327987.4 immunoglobulin superfamily, DCC subclass, member 3 464 2 1 0 1 1 hsa-miR-5001-5p -0.38 -0.38 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CDC42BPG ENST00000342711.5 CDC42 binding protein kinase gamma (DMPK-like) 68 2 0 2 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

FTO ENST00000471389.1 fat mass and obesity associated 240 3 1 2 0 6 hsa-miR-4498 -0.38 -0.43 N/A

CLDN3 ENST00000395145.2 claudin 3 5 1 1 0 0 1 hsa-miR-4498 -0.38 -0.38 N/A

USP50 ENST00000532404.1 ubiquitin specific peptidase 50 5 1 0 1 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A leukocyte immunoglobulin-like receptor, subfamily B (with LILRB4 ENST00000391736.1 5 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A TM and ITIM domains), member 4 PRDM12 ENST00000253008.2 PR domain containing 12 15 2 0 2 0 0 hsa-miR-4498 -0.38 -0.38 N/A

NFAM1 ENST00000329021.5 NFAT activating protein with ITAM motif 1 7 4 0 2 2 5 hsa-miR-5001-5p -0.38 -0.79 N/A

TTL ENST00000233336.6 tubulin tyrosine ligase 442 3 2 1 0 2 hsa-miR-4498 -0.38 -0.57 N/A

DNAH17 ENST00000585328.1 dynein, axonemal, heavy chain 17 20 3 0 2 1 3 hsa-miR-5001-5p -0.38 -0.63 N/A

RAET1E ENST00000532335.1 retinoic acid early transcript 1E 129 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

DDR1 ENST00000446312.1 discoidin domain receptor tyrosine kinase 1 195 5 0 3 2 2 hsa-miR-5001-5p -0.38 -0.38 N/A

HGSNAT ENST00000379644.4 heparan-alpha-glucosaminide N-acetyltransferase 865 3 2 1 0 0 hsa-miR-5001-5p -0.38 -0.39 N/A

BCL2L1 ENST00000376062.2 BCL2-like 1 7726 2 0 1 1 1 hsa-miR-5001-5p -0.38 -0.38 N/A

SCRT1 ENST00000332135.4 scratch homolog 1, zinc finger protein (Drosophila) 5 1 1 0 0 1 hsa-miR-5001-5p -0.38 -0.38 N/A TAF8 RNA polymerase II, TATA box binding protein TAF8 ENST00000372977.3 135 1 1 0 0 1 hsa-miR-5001-5p -0.38 -0.38 N/A (TBP)-associated factor, 43kDa NAT16 ENST00000300303.2 N-acetyltransferase 16 (GCN5-related, putative) 5 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

ZNRF1 ENST00000335325.4 zinc and ring finger 1, E3 ubiquitin protein ligase 519 4 0 2 2 2 hsa-miR-5001-5p -0.38 -0.42 N/A

PDZK1IP1 ENST00000294338.2 PDZK1 interacting protein 1 37 1 0 1 0 1 hsa-miR-5001-5p -0.38 -0.39 N/A solute carrier family 25 (mitochondrial carrier; phosphate SLC25A23 ENST00000301454.4 5 3 0 2 1 1 hsa-miR-4498 -0.38 -0.38 N/A carrier), member 23 VWA3A ENST00000389398.5 von Willebrand factor A domain containing 3A 5 2 0 1 1 1 hsa-miR-5001-5p -0.38 -0.38 N/A transient receptor potential cation channel, subfamily C, TRPC7 ENST00000355180.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A member 7 NBL1 ENST00000375136.3 neuroblastoma 1, DAN family BMP antagonist 852 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.39 N/A UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, B4GALT2 ENST00000434555.2 440 2 0 2 0 1 hsa-miR-4498 -0.38 -0.38 N/A polypeptide 2 LCN2 ENST00000277480.2 lipocalin 2 5 1 0 1 0 0 hsa-miR-4498 -0.38 -0.38 N/A

LINC00908 ENST00000578613.1 long intergenic non-protein coding RNA 908 5 2 0 2 0 1 hsa-miR-4498 -0.38 -0.38 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ST5 ENST00000526757.1 suppression of tumorigenicity 5 139 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

OPRL1 ENST00000336866.2 opiate receptor-like 1 12 2 0 2 0 2 hsa-miR-4498 -0.38 -0.38 N/A

WNT9A ENST00000272164.5 wingless-type MMTV integration site family, member 9A 73 3 1 2 0 5 hsa-miR-4498 -0.38 -0.38 N/A

ANKRD2 ENST00000370655.1 ankyrin repeat domain 2 (stretch responsive muscle) 5 1 0 1 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A solute carrier family 1 (glial high affinity glutamate SLC1A2 ENST00000278379.3 5 3 1 1 1 0 hsa-miR-4498 -0.38 -0.38 N/A transporter), member 2 GNG2 ENST00000556752.1 guanine nucleotide binding protein (G protein), gamma 2 199 2 0 1 1 0 hsa-miR-4498 -0.38 -0.43 N/A

DMRTA2 ENST00000418121.1 DMRT-like family A2 9 2 0 2 0 0 hsa-miR-4498 -0.38 -0.38 N/A

RUNX3 ENST00000399916.1 runt-related transcription factor 3 378 2 1 1 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

PARN ENST00000437198.2 poly(A)-specific ribonuclease 5 1 1 0 0 1 hsa-miR-5001-5p -0.38 -0.38 N/A

GBA ENST00000368373.3 glucosidase, beta, acid 27 6 0 5 1 2 hsa-miR-4498 -0.38 -0.43 N/A

CHMP7 ENST00000313219.7 charged multivesicular body protein 7 124 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.47 N/A

ITGB4 ENST00000200181.3 integrin, beta 4 93 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

GABRA3 ENST00000370314.4 gamma-aminobutyric acid (GABA) A receptor, alpha 3 55 2 0 1 1 1 hsa-miR-4498 -0.38 -0.38 N/A

CD180 ENST00000256447.4 CD180 molecule 5 1 1 0 0 2 hsa-miR-5001-5p -0.38 -0.38 N/A

PALM ENST00000338448.5 paralemmin 341 2 0 2 0 1 hsa-miR-4498 -0.38 -0.38 N/A solute carrier family 32 (GABA vesicular transporter), SLC32A1 ENST00000217420.1 5 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A member 1 KLK7 ENST00000391807.1 kallikrein-related peptidase 7 5 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

MINOS1-NBL1 ENST00000602662.1 MINOS1-NBL1 readthrough 852 1 1 0 0 0 hsa-miR-5001-5p -0.38 -0.39 N/A glutamate receptor, ionotropic, N-methyl D-aspartate- GRINA ENST00000313269.5 5637 1 1 0 0 1 hsa-miR-5001-5p -0.38 -0.38 N/A associated protein 1 (glutamate binding) FBXO27 ENST00000292853.4 F-box protein 27 53 2 0 2 0 0 hsa-miR-5001-5p -0.38 -0.38 N/A

IQSEC3 ENST00000538872.1 IQ motif and Sec7 domain 3 5 6 1 3 2 2 hsa-miR-4498 -0.38 -0.38 N/A

MKNK2 ENST00000591601.1 MAP kinase interacting serine/threonine kinase 2 215 2 0 2 0 2 hsa-miR-4498 -0.38 -0.38 N/A

DCAF12L1 ENST00000371126.1 DDB1 and CUL4 associated factor 12-like 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.38 N/A

CEACAM18 ENST00000396477.4 carcinoembryonic antigen-related cell adhesion molecule 18 5 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

COL5A3 ENST00000264828.3 collagen, type V, alpha 3 5 2 1 0 1 0 hsa-miR-5001-5p -0.37 -0.37 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AP3B2 ENST00000542200.1 adaptor-related protein complex 3, beta 2 subunit 15 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

ERC1 ENST00000355446.5 ELKS/RAB6-interacting/CAST family member 1 159 5 0 4 1 1 hsa-miR-4498 -0.37 -0.38 N/A

FBXO18 ENST00000362091.4 F-box protein, helicase, 18 390 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

ARFGAP1 ENST00000370275.4 ADP-ribosylation factor GTPase activating protein 1 510 3 0 3 0 1 hsa-miR-4498 -0.37 -0.37 N/A

TMEM154 ENST00000304385.3 transmembrane protein 154 5 1 1 0 0 1 hsa-miR-5001-5p -0.37 -0.37 N/A

USP21 ENST00000289865.8 ubiquitin specific peptidase 21 5 1 0 1 0 1 hsa-miR-4498 -0.37 -0.37 N/A

CST3 ENST00000398411.1 cystatin C 11 2 0 1 1 0 hsa-miR-4498 -0.37 -0.51 N/A

SPTB ENST00000389721.5 spectrin, beta, erythrocytic 39 4 2 1 1 4 hsa-miR-5001-5p -0.37 -0.63 N/A

H3F3B ENST00000591890.1 H3 histone, family 3B (H3.3B) 336 1 1 0 0 1 hsa-miR-5001-5p -0.37 -0.49 N/A hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid HSD3B7 ENST00000353250.5 173 2 0 1 1 0 hsa-miR-5001-5p -0.37 -0.37 N/A delta-isomerase 7 RGS14 ENST00000408923.3 regulator of G-protein signaling 14 123 1 0 1 0 1 hsa-miR-5001-5p -0.37 -0.37 N/A

PRELID1 ENST00000303204.4 PRELI domain containing 1 1203 1 0 1 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A pancreatic progenitor cell differentiation and proliferation PPDPF ENST00000370179.3 17979 2 0 1 1 0 hsa-miR-4498 -0.37 -0.44 N/A factor ENG ENST00000344849.3 endoglin 181 2 2 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

INPP5B ENST00000373027.1 inositol polyphosphate-5-phosphatase, 75kDa 12 2 0 2 0 0 hsa-miR-4498 -0.37 -0.39 N/A

TOMM34 ENST00000372813.3 translocase of outer mitochondrial membrane 34 1242 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

SH3PXD2B ENST00000311601.5 SH3 and PX domains 2B 123 5 2 2 1 3 hsa-miR-5001-5p -0.37 -0.4 N/A

MIDN ENST00000591446.2 midnolin 621 2 1 1 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

RASGEF1C ENST00000361132.4 RasGEF domain family, member 1C 5 2 0 2 0 2 hsa-miR-4498 -0.37 -0.37 N/A

RBM38 ENST00000440234.2 RNA binding motif protein 38 18 2 0 1 1 2 hsa-miR-5001-5p -0.37 -0.38 N/A

ABCB8 ENST00000356058.4 ATP-binding cassette, sub-family B (MDR/TAP), member 8 199 3 0 1 2 1 hsa-miR-5001-5p -0.37 -0.54 N/A

RFX1 ENST00000254325.4 regulatory factor X, 1 (influences HLA class II expression) 44 3 0 3 0 1 hsa-miR-4498 -0.37 -0.37 N/A

MIB2 ENST00000378712.1 mindbomb E3 ubiquitin protein ligase 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

EGR3 ENST00000519492.1 early growth response 3 21 2 0 2 0 0 hsa-miR-4498 -0.37 -0.41 N/A

PIAS4 ENST00000262971.2 protein inhibitor of activated STAT, 4 521 1 1 0 0 2 hsa-miR-5001-5p -0.37 -0.37 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score LTK ENST00000355166.5 leukocyte receptor tyrosine kinase 5 1 1 0 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

RP11-625H11.1 ENST00000558940.1 Uncharacterized protein 5 2 0 1 1 0 hsa-miR-5001-5p -0.37 -0.37 N/A

FXN ENST00000396366.2 frataxin 99 3 0 2 1 0 hsa-miR-4498 -0.37 -0.74 N/A

NPM2 ENST00000381530.5 nucleophosmin/nucleoplasmin 2 136 1 0 1 0 0 hsa-miR-4498 -0.37 -0.37 N/A

CHRNE ENST00000293780.4 cholinergic receptor, nicotinic, epsilon (muscle) 11 1 1 0 0 1 hsa-miR-4498 -0.37 -0.37 N/A

CARNS1 ENST00000307823.3 carnosine synthase 1 14 2 0 2 0 0 hsa-miR-4498 -0.37 -0.37 N/A

ALDH4A1 ENST00000375341.3 aldehyde dehydrogenase 4 family, member A1 520 2 0 2 0 0 hsa-miR-4498 -0.37 -0.37 N/A

NPTX1 ENST00000306773.4 neuronal pentraxin I 1876 5 1 2 2 2 hsa-miR-4498 -0.37 -0.38 N/A

PXN ENST00000458477.2 paxillin 484 2 1 1 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

TGM2 ENST00000361475.2 transglutaminase 2 731 2 0 1 1 2 hsa-miR-5001-5p -0.37 -0.4 N/A

BRI3BP ENST00000341446.8 BRI3 binding protein 820 3 0 3 0 1 hsa-miR-4498 -0.37 -0.42 N/A

SLC39A11 ENST00000255559.3 solute carrier family 39, member 11 544 2 1 0 1 0 hsa-miR-5001-5p -0.37 -0.38 N/A

TIMP3 ENST00000266085.6 TIMP metallopeptidase inhibitor 3 7421 1 1 0 0 0 hsa-miR-4498 -0.37 -0.37 N/A

ERGIC3 ENST00000348547.2 ERGIC and golgi 3 7268 1 0 1 0 1 hsa-miR-4498 -0.37 -0.37 N/A

NRN1L ENST00000576147.1 neuritin 1-like 13 1 0 1 0 0 hsa-miR-5001-5p -0.37 -0.37 N/A

CC2D1A ENST00000318003.7 coiled-coil and C2 domain containing 1A 22 2 0 1 1 1 hsa-miR-4498 -0.37 -0.37 N/A

CTD-2616J11.4 ENST00000574814.1 uncharacterized protein LOC147646 23 1 0 0 1 3 hsa-miR-5001-5p -0.37 -0.37 N/A

PLBD2 ENST00000280800.3 phospholipase B domain containing 2 1144 2 0 1 1 3 hsa-miR-4498 -0.37 -0.42 N/A

PCBP3 ENST00000400314.1 poly(rC) binding protein 3 10 1 0 0 1 1 hsa-miR-5001-5p -0.37 -0.37 N/A

RIMS4 ENST00000372851.3 regulating synaptic membrane exocytosis 4 30 4 1 2 1 1 hsa-miR-5001-5p -0.37 -0.37 N/A sparc/osteonectin, cwcv and kazal-like domains proteoglycan SPOCK2 ENST00000373109.2 31 7 1 5 1 3 hsa-miR-4498 -0.37 -1.45 N/A (testican) 2 DDX19B ENST00000288071.6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 690 2 0 2 0 0 hsa-miR-5001-5p -0.37 -0.48 N/A

TOR1A ENST00000351698.4 torsin family 1, member A (torsin A) 2491 3 1 1 1 0 hsa-miR-5001-5p -0.37 -0.44 N/A

LDOC1L ENST00000341255.3 leucine zipper, down-regulated in cancer 1-like 348 2 1 1 0 3 hsa-miR-4498 -0.36 -0.36 N/A

TNRC18 ENST00000399537.4 trinucleotide repeat containing 18 5 1 0 1 0 2 hsa-miR-4498 -0.36 -0.36 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score IL15RA ENST00000379971.1 interleukin 15 receptor, alpha 36 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.43 N/A

LRRC3DN ENST00000596691.1 LRRC3 downstream neighbor (non-protein coding) 221 2 1 1 0 1 hsa-miR-4498 -0.36 -0.58 N/A

TBL3 ENST00000568546.1 transducin (beta)-like 3 57 6 0 6 0 2 hsa-miR-5001-5p -0.36 -0.77 N/A

PSKH1 ENST00000291041.5 protein serine kinase H1 699 2 0 1 1 3 hsa-miR-5001-5p -0.36 -0.37 N/A

LIFR ENST00000263409.4 leukemia inhibitory factor receptor alpha 44 2 1 1 0 1 hsa-miR-5001-5p -0.36 -0.43 N/A

GGACT ENST00000376250.2 gamma-glutamylamine cyclotransferase 164 2 1 0 1 1 hsa-miR-5001-5p -0.36 -0.43 N/A

RNF224 ENST00000445101.2 ring finger protein 224 5 1 0 0 1 1 hsa-miR-4498 -0.36 -0.36 N/A

HPD ENST00000289004.4 4-hydroxyphenylpyruvate dioxygenase 104 1 0 1 0 0 hsa-miR-5001-5p -0.36 -0.37 N/A

DHRS11 ENST00000251312.5 dehydrogenase/reductase (SDR family) member 11 17 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

TAL1 ENST00000371884.2 T-cell acute lymphocytic leukemia 1 5 2 1 0 1 2 hsa-miR-4498 -0.36 -0.36 N/A

SENP1 ENST00000004980.5 SUMO1/sentrin specific peptidase 1 361 2 0 2 0 1 hsa-miR-4498 -0.36 -0.38 N/A

C1orf95 ENST00000366788.3 chromosome 1 open reading frame 95 28 11 2 7 2 4 hsa-miR-5001-5p -0.36 -2.12 N/A

P2RY2 ENST00000311131.2 purinergic receptor P2Y, G-protein coupled, 2 66 5 2 0 3 5 hsa-miR-5001-5p -0.36 -0.67 N/A signal sequence receptor, beta (translocon-associated protein SSR2 ENST00000529008.1 1344 1 0 1 0 1 hsa-miR-4498 -0.36 -0.36 N/A beta) STRBP ENST00000447404.2 spermatid perinuclear RNA binding protein 575 1 0 1 0 1 hsa-miR-4498 -0.36 -0.36 N/A

SIPA1L3 ENST00000222345.6 signal-induced proliferation-associated 1 like 3 1578 2 1 1 0 2 hsa-miR-4498 -0.36 -0.36 N/A

RGSL1 ENST00000294854.8 regulator of G-protein signaling like 1 5 3 0 1 2 0 hsa-miR-5001-5p -0.36 -0.36 N/A

AP4S1 ENST00000334725.4 adaptor-related protein complex 4, sigma 1 subunit 12 1 0 1 0 1 hsa-miR-4498 -0.36 -0.36 N/A

ELK1 ENST00000247161.3 ELK1, member of ETS oncogene family 11 4 2 1 1 1 hsa-miR-5001-5p -0.36 -0.91 N/A

C1orf111 ENST00000367935.5 chromosome 1 open reading frame 111 5 1 0 1 0 1 hsa-miR-4498 -0.36 -0.36 N/A

PIF1 ENST00000268043.4 PIF1 5'-to-3' DNA helicase 19 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

HMG20B ENST00000333651.6 high mobility group 20B 2035 2 0 2 0 0 hsa-miR-4498 -0.36 -0.36 N/A NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, NDUFA11 ENST00000592634.1 32826 2 0 2 0 1 hsa-miR-4498 -0.36 -0.36 N/A 14.7kDa TMEM63B ENST00000259746.9 transmembrane protein 63B 557 2 0 2 0 0 hsa-miR-4498 -0.36 -0.36 N/A

GATSL2 ENST00000426327.3 GATS protein-like 2 5 3 0 2 1 4 hsa-miR-5001-5p -0.36 -0.73 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score DNAJB12 ENST00000338820.3 DnaJ (Hsp40) homolog, subfamily B, member 12 1458 2 0 1 1 2 hsa-miR-4498 -0.36 -0.39 N/A

MOGS ENST00000409065.1 mannosyl-oligosaccharide glucosidase 184 2 0 2 0 0 hsa-miR-4498 -0.36 -0.37 N/A

MAN2B2 ENST00000285599.3 mannosidase, alpha, class 2B, member 2 747 2 0 2 0 1 hsa-miR-4498 -0.36 -0.36 N/A

INF2 ENST00000392634.4 inverted formin, FH2 and WH2 domain containing 484 4* 0 2 1 0 hsa-miR-4498 -0.36 -0.43 N/A

ARHGAP17 ENST00000441763.2 Rho GTPase activating protein 17 1337 3 0 3 0 2 hsa-miR-4498 -0.36 -0.36 N/A

SELL ENST00000236147.4 selectin L 5 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

LCNL1 ENST00000408973.2 lipocalin-like 1 5 2 0 2 0 1 hsa-miR-4498 -0.36 -0.36 N/A

PNMAL2 ENST00000599531.1 paraneoplastic Ma antigen family-like 2 10 3 0 3 0 1 hsa-miR-4498 -0.36 -0.36 N/A

EXOC7 ENST00000607838.1 exocyst complex component 7 1483 5 0 2 3 2 hsa-miR-4498 -0.36 -0.65 N/A

KLHDC7B ENST00000395676.2 kelch domain containing 7B 13 2 1 1 0 1 hsa-miR-5001-5p -0.36 -0.61 N/A

ERF ENST00000222329.4 Ets2 repressor factor 1007 2 0 2 0 1 hsa-miR-4498 -0.36 -0.38 N/A

KRTAP11-1 ENST00000332378.4 keratin associated protein 11-1 5 1 0 1 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

PLD4 ENST00000540372.1 phospholipase D family, member 4 5 1 0 1 0 1 hsa-miR-5001-5p -0.36 -0.36 N/A solute carrier family 6 (neurotransmitter transporter), SLC6A1 ENST00000287766.4 5 1 1 0 0 1 hsa-miR-4498 -0.36 -0.36 N/A member 1 ATP2B2 ENST00000352432.4 ATPase, Ca++ transporting, plasma membrane 2 170 5 1 3 1 1 hsa-miR-5001-5p -0.36 -0.4 N/A

TRABD2B ENST00000606738.2 TraB domain containing 2B 244 4 3 1 0 1 hsa-miR-4498 -0.36 -0.48 N/A

RP11-192H23.4 ENST00000534850.1 Uncharacterized protein 22 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

ECE1 ENST00000415912.2 endothelin converting enzyme 1 1166 2 0 1 1 5 hsa-miR-5001-5p -0.36 -0.38 N/A

CPEB3 ENST00000412050.4 cytoplasmic polyadenylation element binding protein 3 48 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

WDFY4 ENST00000413659.2 WDFY family member 4 5 4 0 3 1 2 hsa-miR-5001-5p -0.36 -0.36 N/A

BST1 ENST00000382346.3 bone marrow stromal cell antigen 1 44 1 0 1 0 0 hsa-miR-4498 -0.36 -0.36 N/A

BEND6 ENST00000370750.2 BEN domain containing 6 11 2 0 0 2 0 hsa-miR-5001-5p -0.36 -0.36 N/A

ZNF791 ENST00000446165.1 zinc finger protein 791 242 1 0 1 0 0 hsa-miR-4498 -0.36 -0.36 N/A

CDCP2 ENST00000371330.1 CUB domain containing protein 2 5 1 0 1 0 0 hsa-miR-4498 -0.36 -0.36 N/A

PPME1 ENST00000328257.8 protein phosphatase methylesterase 1 343 2 0 1 1 0 hsa-miR-4498 -0.36 -0.36 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMPRSS5 ENST00000536856.1 transmembrane protease, serine 5 8 1 1 0 0 0 hsa-miR-5001-5p -0.36 -0.36 N/A

ARHGAP27 ENST00000532038.1 Rho GTPase activating protein 27 5 2 0 2 0 0 hsa-miR-4498 -0.36 -0.36 N/A

ARVCF ENST00000263207.3 armadillo repeat gene deleted in velocardiofacial syndrome 19 2 1 1 0 0 hsa-miR-4498 -0.36 -0.36 N/A

FAAH ENST00000243167.8 fatty acid amide hydrolase 19 3 0 1 2 0 hsa-miR-5001-5p -0.36 -0.51 N/A

CNTN2 ENST00000331830.4 contactin 2 (axonal) 5 4 0 1 3 3 hsa-miR-5001-5p -0.35 -0.35 N/A

GPR156 ENST00000464295.1 G protein-coupled receptor 156 12 2 1 0 1 0 hsa-miR-5001-5p -0.35 -0.41 N/A

PRNT ENST00000418528.1 prion protein (testis specific) 5 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

GLYR1 ENST00000436648.5 glyoxylate reductase 1 homolog (Arabidopsis) 31 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

PGLYRP2 ENST00000292609.4 peptidoglycan recognition protein 2 22 1 0 1 0 1 hsa-miR-4498 -0.35 -0.35 N/A

DUSP3 ENST00000226004.3 dual specificity phosphatase 3 836 2 0 2 0 3 hsa-miR-4498 -0.35 -0.54 N/A

NUCB1 ENST00000405315.4 nucleobindin 1 851 2 0 2 0 2 hsa-miR-4498 -0.35 -0.44 N/A

EPHB6 ENST00000392957.2 EPH receptor B6 7 1 0 1 0 1 hsa-miR-5001-5p -0.35 -0.35 N/A

ZNF821 ENST00000564134.1 zinc finger protein 821 56 1 1 0 0 1 hsa-miR-5001-5p -0.35 -0.39 N/A

MFAP1 ENST00000267812.3 microfibrillar-associated protein 1 882 1 0 1 0 0 hsa-miR-4498 -0.35 -0.36 N/A

HBA1 ENST00000320868.5 hemoglobin, alpha 1 5 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

ORAI2 ENST00000356387.2 ORAI calcium release-activated calcium modulator 2 217 5 1 3 1 7 hsa-miR-5001-5p -0.35 -2.04 N/A

LAT ENST00000395461.3 linker for activation of T cells 41 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

GLTP ENST00000318348.4 glycolipid transfer protein 5 2 0 0 2 1 hsa-miR-4498 -0.35 -0.35 N/A ATP synthase, H+ transporting, mitochondrial F1 complex, ATP5D ENST00000215375.2 5503 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A delta subunit THRA ENST00000450525.2 thyroid hormone receptor, alpha 547 2 0 2 0 1 hsa-miR-4498 -0.35 -0.35 N/A

UPF2 ENST00000356352.2 UPF2 regulator of nonsense transcripts homolog (yeast) 5 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A WAS protein homolog associated with actin, golgi WHAMM ENST00000286760.4 834 1 1 0 0 0 hsa-miR-4498 -0.35 -0.35 N/A membranes and microtubules PCDH1 ENST00000503492.1 protocadherin 1 30 4 0 4 0 3 hsa-miR-4498 -0.35 -0.38 N/A

CD300LB ENST00000392621.1 CD300 molecule-like family member b 5 3 0 3 0 0 hsa-miR-4498 -0.35 -0.49 N/A

SH3PXD2A ENST00000369774.4 SH3 and PX domains 2A 152 4 0 4 0 4 hsa-miR-4498 -0.35 -0.42 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZC3H10 ENST00000257940.2 zinc finger CCCH-type containing 10 49 1 1 0 0 1 hsa-miR-5001-5p -0.35 -0.35 N/A

ANKRD63 ENST00000434396.1 ankyrin repeat domain 63 5 3 0 3 0 1 hsa-miR-4498 -0.35 -0.35 N/A

SPINT1 ENST00000344051.4 serine peptidase inhibitor, Kunitz type 1 1591 2 0 2 0 2 hsa-miR-4498 -0.35 -0.35 N/A

FRAT1 ENST00000371021.3 frequently rearranged in advanced T-cell lymphomas 631 2 0 1 1 0 hsa-miR-4498 -0.35 -0.35 N/A

CHRNA4 ENST00000370263.4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 5 6 0 6 0 5 hsa-miR-4498 -0.35 -0.4 N/A

C9orf37 ENST00000371417.3 chromosome 9 open reading frame 37 12 2 0 2 0 0 hsa-miR-4498 -0.35 -0.35 N/A

TYK2 ENST00000524462.1 tyrosine kinase 2 301 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

NRG2 ENST00000394770.1 neuregulin 2 9 4 0 3 1 0 hsa-miR-4498 -0.35 -0.63 N/A

C14orf132 ENST00000555004.1 chromosome 14 open reading frame 132 217 3 0 3 0 2 hsa-miR-4498 -0.35 -0.59 N/A

MMD2 ENST00000406755.1 monocyte to macrophage differentiation-associated 2 5 1 0 0 1 3 hsa-miR-5001-5p -0.35 -0.35 N/A

REN ENST00000367195.2 renin 68 1 0 1 0 1 hsa-miR-4498 -0.35 -0.35 N/A

CHRNG ENST00000389494.3 cholinergic receptor, nicotinic, gamma (muscle) 5 1 0 0 1 2 hsa-miR-5001-5p -0.35 -0.35 N/A

CKB ENST00000348956.2 creatine kinase, brain 71667 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

ZNF219 ENST00000360947.3 zinc finger protein 219 1023 2 1 1 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

SEPW1 ENST00000509570.2 selenoprotein W, 1 303 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

CCDC85C ENST00000380243.4 coiled-coil domain containing 85C 86 2 2 0 0 2 hsa-miR-5001-5p -0.35 -0.37 N/A

USP42 ENST00000306177.5 ubiquitin specific peptidase 42 86 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

GPR153 ENST00000377893.2 G protein-coupled receptor 153 39 2 0 2 0 0 hsa-miR-4498 -0.35 -0.35 N/A

BIRC7 ENST00000217169.3 baculoviral IAP repeat containing 7 25 1 0 1 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

ODF4 ENST00000328248.2 outer dense fiber of sperm tails 4 5 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A

USP39 ENST00000409766.3 ubiquitin specific peptidase 39 6197 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

ZNF345 ENST00000589046.1 zinc finger protein 345 24 1 0 1 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

BTBD9 ENST00000314100.6 BTB (POZ) domain containing 9 65 5 2 2 1 4 hsa-miR-4498 -0.35 -0.7 N/A

CYB5B ENST00000512062.1 cytochrome b5 type B (outer mitochondrial membrane) 2472 2 0 2 0 1 hsa-miR-5001-5p -0.35 -0.4 N/A

PNPLA6 ENST00000221249.6 patatin-like phospholipase domain containing 6 429 1 0 1 0 0 hsa-miR-4498 -0.35 -0.35 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CD164L2 ENST00000374027.3 CD164 sialomucin-like 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.35 N/A

STIM1 ENST00000527651.1 stromal interaction molecule 1 1672 1 1 0 0 3 hsa-miR-5001-5p -0.35 -0.35 N/A

MRPS2 ENST00000371785.1 mitochondrial ribosomal protein S2 872 1 0 1 0 1 hsa-miR-4498 -0.35 -0.35 N/A

DOK7 ENST00000507039.1 docking protein 7 19 2 1 0 1 3 hsa-miR-5001-5p -0.35 -0.35 N/A

CAMKK2 ENST00000538733.1 calcium/calmodulin-dependent protein kinase kinase 2, beta 1157 1 1 0 0 0 hsa-miR-4498 -0.35 -0.35 N/A

CAMK2G ENST00000351293.3 calcium/calmodulin-dependent protein kinase II gamma 14 2 0 2 0 2 hsa-miR-4498 -0.35 -0.35 N/A

SGOL1 ENST00000442720.1 shugoshin-like 1 (S. pombe) 766 1 1 0 0 0 hsa-miR-5001-5p -0.35 -0.46 N/A

CCDC78 ENST00000293889.6 coiled-coil domain containing 78 6 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

KIF21B ENST00000332129.2 kinesin family member 21B 12 6 1 4 1 3 hsa-miR-5001-5p -0.34 -0.34 N/A MFNG O-fucosylpeptide 3-beta-N- MFNG ENST00000416983.3 14 2 0 0 2 0 hsa-miR-5001-5p -0.34 -0.34 N/A acetylglucosaminyltransferase TMEM178A ENST00000281961.2 transmembrane protein 178A 141 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

CLPTM1 ENST00000337392.5 cleft lip and palate associated transmembrane protein 1 1113 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.34 N/A

RECQL5 ENST00000423245.2 RecQ protein-like 5 129 1 0 0 1 1 hsa-miR-5001-5p -0.34 -0.43 N/A

TBC1D24 ENST00000567020.1 TBC1 domain family, member 24 269 3 1 1 1 3 hsa-miR-5001-5p -0.34 -0.34 N/A

CTXN1 ENST00000318978.4 cortexin 1 405 2 0 2 0 1 hsa-miR-4498 -0.34 -0.34 N/A

NAA40 ENST00000377793.4 N(alpha)-acetyltransferase 40, NatD catalytic subunit 217 2 0 2 0 1 hsa-miR-4498 -0.34 -0.43 N/A

CTD-2228K2.5 ENST00000342584.3 Uncharacterized protein 199 3* 0 1 1 1 hsa-miR-5001-5p -0.34 -0.41 N/A

CASP4 ENST00000444739.2 caspase 4, apoptosis-related cysteine peptidase 21 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

KDM2A ENST00000398645.2 lysine (K)-specific demethylase 2A 729 2 1 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A

RPP14 ENST00000445193.3 ribonuclease P/MRP 14kDa subunit 1612 1 0 1 0 1 hsa-miR-5001-5p -0.34 -0.39 N/A

ZNF573 ENST00000590414.2 zinc finger protein 573 12 3 1 1 1 0 hsa-miR-5001-5p -0.34 -0.57 N/A

RARRES2 ENST00000223271.3 retinoic acid receptor responder (tazarotene induced) 2 345 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

CCDC137 ENST00000329214.8 coiled-coil domain containing 137 5 2 0 0 2 0 hsa-miR-5001-5p -0.34 -0.34 N/A

HIF3A ENST00000377670.4 hypoxia inducible factor 3, alpha subunit 5 1 0 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A

CDK2 ENST00000266970.4 cyclin-dependent kinase 2 6789 1 0 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CAMKV ENST00000296471.7 CaM kinase-like vesicle-associated 47 3 1 1 1 0 hsa-miR-5001-5p -0.34 -0.52 N/A

P2RY8 ENST00000381297.4 purinergic receptor P2Y, G-protein coupled, 8 5 3 1 2 0 0 hsa-miR-4498 -0.34 -0.34 N/A

CLEC4F ENST00000272367.2 C-type lectin domain family 4, member F 5 1 0 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A

TXLNB ENST00000358430.3 taxilin beta 5 2 0 1 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, B4GALT1 ENST00000379731.4 2265 2 0 2 0 0 hsa-miR-4498 -0.34 -0.35 N/A polypeptide 1 TCTE1 ENST00000371505.4 t-complex-associated-testis-expressed 1 34 2 1 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A

C17orf59 ENST00000389017.4 chromosome 17 open reading frame 59 664 2 0 2 0 0 hsa-miR-4498 -0.34 -0.34 N/A

POTEI ENST00000451531.2 POTE ankyrin domain family, member I 5 2 1 0 1 2 hsa-miR-5001-5p -0.34 -0.34 N/A

FAM83A ENST00000518448.1 family with sequence similarity 83, member A 22 3 0 2 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A

MMP19 ENST00000409200.3 matrix metallopeptidase 19 135 1 0 1 0 2 hsa-miR-4498 -0.34 -0.39 N/A

CDH24 ENST00000397359.3 cadherin 24, type 2 44 2 0 1 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A

DOCK5 ENST00000276440.7 dedicator of cytokinesis 5 504 1 1 0 0 4 hsa-miR-5001-5p -0.34 -0.35 N/A

GFI1 ENST00000370332.1 growth factor independent 1 transcription repressor 154 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

ETV7 ENST00000340181.4 ets variant 7 8 5 2 3 0 3 hsa-miR-4498 -0.34 -0.6 N/A guanine nucleotide binding protein (G protein), beta GNB3 ENST00000229264.3 49 1 0 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A polypeptide 3 SFRP5 ENST00000266066.3 secreted frizzled-related protein 5 28 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.34 N/A

DNAJB5 ENST00000545841.1 DnaJ (Hsp40) homolog, subfamily B, member 5 379 1 0 1 0 1 hsa-miR-4498 -0.34 -0.34 N/A

SCARB1 ENST00000261693.6 scavenger receptor class B, member 1 186 2 0 2 0 2 hsa-miR-4498 -0.34 -0.34 N/A

POLDIP2 ENST00000540200.1 polymerase (DNA-directed), delta interacting protein 2 4344 3 0 2 1 0 hsa-miR-4498 -0.34 -0.6 N/A

TCF7 ENST00000518915.1 transcription factor 7 (T-cell specific, HMG-box) 883 2 0 1 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A v-maf avian musculoaponeurotic fibrosarcoma oncogene MAFG ENST00000357736.4 5 2 0 2 0 3 hsa-miR-4498 -0.34 -0.34 N/A homolog G DGUOK ENST00000264093.4 deoxyguanosine kinase 18193 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

PARM1 ENST00000513238.1 prostate androgen-regulated mucin-like protein 1 161 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.39 N/A

L3MBTL2 ENST00000216237.5 l(3)mbt-like 2 (Drosophila) 1085 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.34 N/A erythroblast membrane-associated protein (Scianna blood ERMAP ENST00000372514.3 121 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.34 N/A group) Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GCKR ENST00000424318.2 glucokinase (hexokinase 4) regulator 51 2 0 1 1 0 hsa-miR-4498 -0.34 -0.34 N/A

CNN2 ENST00000263097.4 calponin 2 699 2 0 2 0 0 hsa-miR-4498 -0.34 -0.34 N/A

AP5S1 ENST00000379573.2 adaptor-related protein complex 5, sigma 1 subunit 492 1 0 1 0 1 hsa-miR-5001-5p -0.34 -0.34 N/A

PLXDC2 ENST00000377252.4 plexin domain containing 2 506 3 1 0 2 0 hsa-miR-5001-5p -0.34 -0.58 N/A

MAML1 ENST00000292599.3 mastermind-like 1 (Drosophila) 910 2 1 0 1 2 hsa-miR-5001-5p -0.34 -0.34 N/A

PIANP ENST00000534837.1 PILR alpha associated neural protein 8 2 1 1 0 4 hsa-miR-5001-5p -0.34 -0.36 N/A

VTCN1 ENST00000359008.4 V-set domain containing T cell activation inhibitor 1 5 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

AL020996.1 ENST00000536896.1 Uncharacterized protein 5 2 0 1 1 0 hsa-miR-4498 -0.34 -0.34 N/A

IFITM10 ENST00000340134.4 interferon induced transmembrane protein 10 7 3 1 0 2 1 hsa-miR-4498 -0.34 -0.46 N/A

DNLZ ENST00000371739.3 DNL-type zinc finger 373 1 0 1 0 1 hsa-miR-4498 -0.34 -0.36 N/A

CDKAL1 ENST00000274695.4 CDK5 regulatory subunit associated protein 1-like 1 541 1 1 0 0 0 hsa-miR-5001-5p -0.34 -0.35 N/A

TSPO2 ENST00000373158.2 translocator protein 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.34 -0.34 N/A

CDK5R2 ENST00000302625.4 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 24 2 0 1 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A

KCTD20 ENST00000373731.2 potassium channel tetramerization domain containing 20 88 2 0 1 1 1 hsa-miR-4498 -0.34 -0.38 N/A

KBTBD12 ENST00000405256.1 kelch repeat and BTB (POZ) domain containing 12 5 4 0 2 2 0 hsa-miR-5001-5p -0.34 -0.34 N/A

EFNA2 ENST00000215368.2 ephrin-A2 83 2 0 1 1 2 hsa-miR-5001-5p -0.34 -0.34 N/A

SYT5 ENST00000590851.1 synaptotagmin V 5 2 0 1 1 1 hsa-miR-4498 -0.34 -0.34 N/A

FAM183A ENST00000410048.1 family with sequence similarity 183, member A 5 1 0 0 1 0 hsa-miR-5001-5p -0.34 -0.34 N/A

ARID3C ENST00000378909.2 AT rich interactive domain 3C (BRIGHT-like) 5 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

TBC1D13 ENST00000372648.5 TBC1 domain family, member 13 2204 2 0 2 0 2 hsa-miR-4498 -0.34 -0.34 N/A

TTC34 ENST00000401094.6 tetratricopeptide repeat domain 34 5 1 0 1 0 0 hsa-miR-4498 -0.34 -0.34 N/A

HMGXB4 ENST00000216106.5 HMG box domain containing 4 966 1 0 1 0 0 hsa-miR-4498 -0.33 -0.34 N/A

AKNA ENST00000307564.4 AT-hook transcription factor 10 2 0 2 0 0 hsa-miR-4498 -0.33 -0.73 N/A

ADD1 ENST00000398125.1 adducin 1 (alpha) 460 4 0 4 0 1 hsa-miR-4498 -0.33 -0.33 N/A

CCK ENST00000334681.5 cholecystokinin 5 1 0 0 1 0 hsa-miR-5001-5p -0.33 -0.33 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SLA2 ENST00000262866.4 Src-like-adaptor 2 5 1 0 1 0 1 hsa-miR-4498 -0.33 -0.33 N/A

STK38 ENST00000229812.7 serine/threonine kinase 38 156 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

TSTA3 ENST00000529064.1 tissue specific transplantation antigen P35B 24 1 0 1 0 1 hsa-miR-5001-5p -0.33 -0.33 N/A

PLEKHO2 ENST00000323544.4 pleckstrin homology domain containing, family O member 2 279 2 0 2 0 1 hsa-miR-4498 -0.33 -0.33 N/A

ZNF341 ENST00000342427.2 zinc finger protein 341 10 2 0 0 2 0 hsa-miR-5001-5p -0.33 -0.33 N/A

PLEKHO1 ENST00000369124.4 pleckstrin homology domain containing, family O member 1 144 3 1 1 1 2 hsa-miR-4498 -0.33 -0.96 N/A

TRAF7 ENST00000326181.6 TNF receptor-associated factor 7, E3 ubiquitin protein ligase 1505 2 0 2 0 1 hsa-miR-4498 -0.33 -0.33 N/A

PI16 ENST00000373674.3 peptidase inhibitor 16 5 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A

ATXN2 ENST00000550104.1 ataxin 2 7 1 0 0 1 1 hsa-miR-4498 -0.33 -0.33 N/A

ZBTB39 ENST00000300101.2 zinc finger and BTB domain containing 39 7 3 0 2 1 3 hsa-miR-4498 -0.33 -0.33 N/A

KBTBD13 ENST00000432196.2 kelch repeat and BTB (POZ) domain containing 13 5 2 0 2 0 0 hsa-miR-4498 -0.33 -0.33 N/A

ZNF496 ENST00000294753.4 zinc finger protein 496 391 2 1 0 1 1 hsa-miR-5001-5p -0.33 -0.6 N/A

ECEL1 ENST00000304546.1 endothelin converting enzyme-like 1 6 2 0 2 0 0 hsa-miR-4498 -0.33 -0.33 N/A

RNF4 ENST00000511859.1 ring finger protein 4 33 2 0 1 1 0 hsa-miR-4498 -0.33 -0.45 N/A

ZNF136 ENST00000343979.4 zinc finger protein 136 33 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

MSX1 ENST00000382723.4 msh homeobox 1 239 1 0 1 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

ALDH3B1 ENST00000539229.1 aldehyde dehydrogenase 3 family, member B1 1512 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A XK, Kell blood group complex subunit-related family, XKR7 ENST00000562532.2 5 5 1 3 1 1 hsa-miR-4498 -0.33 -0.33 N/A member 7 GINS2 ENST00000253462.3 GINS complex subunit 2 (Psf2 homolog) 136 1 0 1 0 2 hsa-miR-4498 -0.33 -0.38 N/A

EEF2K ENST00000263026.5 eukaryotic elongation factor-2 kinase 115 4 1 3 0 1 hsa-miR-4498 -0.33 -0.59 N/A steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 SRD5A1 ENST00000274192.5 2684 2 1 0 1 0 hsa-miR-4498 -0.33 -0.46 N/A alpha-steroid delta 4-dehydrogenase alpha 1) FAM117A ENST00000240364.2 family with sequence similarity 117, member A 185 2 0 2 0 2 hsa-miR-4498 -0.33 -0.33 N/A

ZNF76 ENST00000373953.3 zinc finger protein 76 6 2 0 1 1 0 hsa-miR-5001-5p -0.33 -0.33 N/A

TNK1 ENST00000570896.1 tyrosine kinase, non-receptor, 1 51 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

BCL6 ENST00000406870.2 B-cell CLL/lymphoma 6 20 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score LAD1 ENST00000391967.2 ladinin 1 89 1 1 0 0 1 hsa-miR-5001-5p -0.33 -0.33 N/A

TMEM150A ENST00000306353.3 transmembrane protein 150A 814 2* 0 1 0 0 hsa-miR-4498 -0.33 -0.34 N/A

S100A11 ENST00000271638.2 S100 calcium binding protein A11 433 1 0 0 1 0 hsa-miR-5001-5p -0.33 -0.33 N/A

CEP170B ENST00000414716.3 centrosomal protein 170B 326 1 0 1 0 2 hsa-miR-4498 -0.33 -0.33 N/A

C16orf74 ENST00000602583.1 chromosome 16 open reading frame 74 1205 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A

ASB6 ENST00000277459.4 ankyrin repeat and SOCS box containing 6 725 5 2 2 1 1 hsa-miR-5001-5p -0.33 -0.85 N/A

ASIC4 ENST00000347842.3 acid-sensing (proton-gated) ion channel family member 4 5 2 0 2 0 0 hsa-miR-4498 -0.33 -0.33 N/A

RARA ENST00000425707.3 retinoic acid receptor, alpha 560 3 0 3 0 2 hsa-miR-5001-5p -0.33 -0.45 N/A

DNAH10OS ENST00000514254.2 dynein, axonemal, heavy chain 10 opposite strand 89 1 0 0 1 1 hsa-miR-5001-5p -0.33 -0.33 N/A

MPZL1 ENST00000474859.1 myelin protein zero-like 1 3146 2 1 1 0 1 hsa-miR-4498 -0.33 -0.37 N/A

OXLD1 ENST00000571503.1 oxidoreductase-like domain containing 1 1608 1 0 1 0 1 hsa-miR-5001-5p -0.33 -0.33 N/A

CHMP6 ENST00000325167.5 charged multivesicular body protein 6 227 2 0 2 0 2 hsa-miR-4498 -0.33 -0.33 N/A

C11orf68 ENST00000438576.2 chromosome 11 open reading frame 68 1192 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A

ZC3H12A ENST00000373087.6 zinc finger CCCH-type containing 12A 94 2 0 1 1 0 hsa-miR-4498 -0.33 -0.33 N/A

DCDC2B ENST00000409358.1 doublecortin domain containing 2B 5 1 0 0 1 2 hsa-miR-5001-5p -0.33 -0.33 N/A

PPP1R17 ENST00000342032.3 protein phosphatase 1, regulatory subunit 17 5 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A sema domain, immunoglobulin domain (Ig), transmembrane SEMA4G ENST00000210633.3 1015 2 0 1 1 0 hsa-miR-5001-5p -0.33 -0.33 N/A domain (TM) and short cytoplasmic domain, (semaphorin) KAT2A ENST00000225916.5 K(lysine) acetyltransferase 2A 468 2 0 1 1 1 hsa-miR-4498 -0.33 -0.33 N/A

SYPL2 ENST00000369872.3 synaptophysin-like 2 69 1 1 0 0 2 hsa-miR-5001-5p -0.33 -0.33 N/A

ARMC7 ENST00000581078.1 armadillo repeat containing 7 64 2 0 1 1 0 hsa-miR-5001-5p -0.33 -0.36 N/A

TMEM184B ENST00000361906.3 transmembrane protein 184B 1362 4 0 3 1 3 hsa-miR-5001-5p -0.33 -0.55 N/A

FKBP8 ENST00000597960.3 FK506 binding protein 8, 38kDa 118 2 0 1 1 1 hsa-miR-5001-5p -0.33 -0.33 N/A

LMTK3 ENST00000600059.1 lemur tyrosine kinase 3 5 2 0 2 0 0 hsa-miR-4498 -0.33 -0.33 N/A

CBX2 ENST00000310942.4 chromobox homolog 2 1816 3 2 0 1 3 hsa-miR-5001-5p -0.33 -0.33 N/A

HDAC6 ENST00000334136.5 histone deacetylase 6 68 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.43 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NPC1L1 ENST00000289547.4 NPC1-like 1 55 1 1 0 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

ALDH3A2 ENST00000339618.4 aldehyde dehydrogenase 3 family, member A2 940 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A solute carrier family 25 (mitochondrial carrier, brain), SLC25A14 ENST00000218197.5 46 1 0 1 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A member 14 TRADD ENST00000345057.4 TNFRSF1A-associated via death domain 117 1 0 1 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A

PHLDA2 ENST00000314222.4 pleckstrin homology-like domain, family A, member 2 755 1 0 1 0 0 hsa-miR-5001-5p -0.33 -0.33 N/A UDP-GlcNAc:betaGal beta-1,3-N- B3GNT7 ENST00000287590.5 5 2 0 1 1 4 hsa-miR-4498 -0.33 -0.33 N/A acetylglucosaminyltransferase 7 AC073610.5 ENST00000537495.1 Uncharacterized protein 11 1 0 1 0 0 hsa-miR-4498 -0.33 -0.33 N/A

CLCN6 ENST00000312413.6 chloride channel, voltage-sensitive 6 227 3 1 2 0 2 hsa-miR-5001-5p -0.33 -0.33 N/A

CD80 ENST00000264246.3 CD80 molecule 5 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.33 N/A

AC002472.13 ENST00000543388.1 Leucine-rich repeat-containing protein LOC400891 5 2* 0 1 0 1 hsa-miR-4498 -0.32 -0.32 N/A

LYRM9 ENST00000460380.2 LYR motif containing 9 191 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

C16orf92 ENST00000300575.2 chromosome 16 open reading frame 92 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

PLVAP ENST00000252590.4 plasmalemma vesicle associated protein 5 1 0 1 0 1 hsa-miR-5001-5p -0.32 -0.32 N/A

KIAA0513 ENST00000566428.1 KIAA0513 5 4 2 2 0 2 hsa-miR-5001-5p -0.32 -0.32 N/A

FNDC1 ENST00000297267.9 fibronectin type III domain containing 1 137 1 0 1 0 1 hsa-miR-4498 -0.32 -0.32 N/A

TBC1D5 ENST00000253692.7 TBC1 domain family, member 5 400 2 0 2 0 1 hsa-miR-4498 -0.32 -0.33 N/A

COL26A1 ENST00000313669.7 collagen, type XXVI, alpha 1 223 2 0 1 1 1 hsa-miR-5001-5p -0.32 -0.33 N/A

DCTN5 ENST00000300087.2 dynactin 5 (p25) 764 3 0 2 1 1 hsa-miR-4498 -0.32 -0.36 N/A

ZFP69B ENST00000484445.1 ZFP69 zinc finger protein B 176 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.33 N/A

TPM4 ENST00000300933.4 tropomyosin 4 332 1 1 0 0 1 hsa-miR-5001-5p -0.32 -0.37 N/A

COPE ENST00000262812.4 coatomer protein complex, subunit epsilon 747 1 0 1 0 1 hsa-miR-4498 -0.32 -0.32 N/A

SEPT3 ENST00000396425.3 septin 3 241 2 0 1 1 3 hsa-miR-5001-5p -0.32 -0.32 N/A

AKT3 ENST00000366539.1 v-akt murine thymoma viral oncogene homolog 3 168 3 1 2 0 0 hsa-miR-4498 -0.32 -0.52 N/A

DUSP22 ENST00000419235.2 dual specificity phosphatase 22 1330 2 0 1 1 0 hsa-miR-5001-5p -0.32 -0.32 N/A

FAM101B ENST00000329099.4 family with sequence similarity 101, member B 126 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GPHA2 ENST00000279168.2 glycoprotein hormone alpha 2 8 1 0 1 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

LENG8 ENST00000326764.5 leukocyte receptor cluster (LRC) member 8 244 2 0 2 0 1 hsa-miR-4498 -0.32 -0.32 N/A

ABLIM2 ENST00000361737.5 actin binding LIM protein family, member 2 78 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

GPR68 ENST00000531499.2 G protein-coupled receptor 68 5 2 0 0 2 2 hsa-miR-5001-5p -0.32 -0.32 N/A

HRH1 ENST00000397056.1 histamine receptor H1 130 2 2 0 0 1 hsa-miR-4498 -0.32 -0.58 N/A

UBE2L3 ENST00000342192.4 ubiquitin-conjugating enzyme E2L 3 1318 1 1 0 0 4 hsa-miR-5001-5p -0.32 -0.34 N/A

CTSW ENST00000528419.1 cathepsin W 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

MYO1D ENST00000318217.5 myosin ID 16 4 0 2 2 1 hsa-miR-4498 -0.32 -0.32 N/A

CMTM1 ENST00000533666.1 CKLF-like MARVEL transmembrane domain containing 1 16 1 0 1 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

CDCA4 ENST00000336219.3 cell division cycle associated 4 194 2 0 0 2 3 hsa-miR-5001-5p -0.32 -0.35 N/A

JMJD4 ENST00000366758.3 jumonji domain containing 4 1570 3 0 3 0 0 hsa-miR-4498 -0.32 -0.38 N/A

XRRA1 ENST00000527087.1 X-ray radiation resistance associated 1 136 2 1 0 1 2 hsa-miR-5001-5p -0.32 -0.45 N/A

CD300LF ENST00000361254.4 CD300 molecule-like family member f 5 1 0 1 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

LRRC48 ENST00000399187.1 leucine rich repeat containing 48 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

LCA5 ENST00000369846.4 Leber congenital amaurosis 5 8 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

APH1A ENST00000360244.4 APH1A gamma secretase subunit 475 2 0 2 0 0 hsa-miR-4498 -0.32 -0.32 N/A solute carrier family 25 (mitochondrial iron transporter), SLC25A37 ENST00000519973.1 145 1 0 1 0 1 hsa-miR-4498 -0.32 -0.33 N/A member 37 APLN ENST00000307484.6 apelin 48 2 1 1 0 0 hsa-miR-4498 -0.32 -0.72 N/A

C9orf9 ENST00000372136.3 chromosome 9 open reading frame 9 44 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

LCN12 ENST00000371633.3 lipocalin 12 5 1 0 1 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

MSN ENST00000360270.5 moesin 5947 1 0 1 0 1 hsa-miR-5001-5p -0.32 -0.32 N/A

RAB3B ENST00000371655.3 RAB3B, member RAS oncogene family 611 2 0 1 1 2 hsa-miR-5001-5p -0.32 -0.41 N/A

LYPD2 ENST00000359228.3 LY6/PLAUR domain containing 2 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

MYOZ3 ENST00000297130.4 myozenin 3 8 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

LRRC14B ENST00000328278.3 leucine rich repeat containing 14B 0 2 0 1 1 0 hsa-miR-4498 -0.32 -0.32 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GPR144 ENST00000334810.1 G protein-coupled receptor 144 5 4 1 2 1 1 hsa-miR-5001-5p -0.32 -0.32 N/A

TMUB1 ENST00000297533.4 transmembrane and ubiquitin-like domain containing 1 79 1 0 1 0 1 hsa-miR-5001-5p -0.32 -0.32 N/A

LRP10 ENST00000359591.4 low density lipoprotein receptor-related protein 10 939 4 0 3 1 0 hsa-miR-4498 -0.32 -0.53 N/A

CBX8 ENST00000269385.4 chromobox homolog 8 474 2 0 1 1 1 hsa-miR-4498 -0.32 -0.45 N/A

UCP2 ENST00000536983.1 uncoupling protein 2 (mitochondrial, proton carrier) 32 1 0 0 1 0 hsa-miR-4498 -0.32 -0.32 N/A

EME1 ENST00000338165.4 essential meiotic structure-specific endonuclease 1 13 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

PRIMA1 ENST00000393140.1 proline rich membrane anchor 1 5 3 0 1 2 0 hsa-miR-5001-5p -0.32 -0.32 N/A

RBCK1 ENST00000356286.5 RanBP-type and C3HC4-type zinc finger containing 1 2123 1 0 1 0 1 hsa-miR-5001-5p -0.32 -0.32 N/A

SLC31A2 ENST00000259392.3 solute carrier family 31 (copper transporter), member 2 110 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

KLK5 ENST00000391809.2 kallikrein-related peptidase 5 5 1 0 1 0 1 hsa-miR-4498 -0.32 -0.32 N/A

FGF19 ENST00000294312.3 fibroblast growth factor 19 19 3 1 2 0 0 hsa-miR-4498 -0.32 -0.88 N/A

CLDND1 ENST00000341181.6 claudin domain containing 1 24 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.56 N/A

TMEM185B ENST00000426077.2 transmembrane protein 185B 1146 3 1 2 0 3 hsa-miR-4498 -0.32 -0.5 N/A

ATP6V0D2 ENST00000285393.3 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A protein tyrosine phosphatase, non-receptor type 5 (striatum- PTPN5 ENST00000477854.1 5 2 0 1 1 0 hsa-miR-5001-5p -0.32 -0.32 N/A enriched) DDX10 ENST00000322536.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 9 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

LYVE1 ENST00000256178.3 lymphatic vessel endothelial hyaluronan receptor 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

TUBG2 ENST00000251412.7 tubulin, gamma 2 1587 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

ALOXE3 ENST00000380149.1 arachidonate lipoxygenase 3 5 1 1 0 0 0 hsa-miR-5001-5p -0.32 -0.32 N/A

PRY ENST00000303728.1 PTPN13-like, Y-linked 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

PRY2 ENST00000303804.1 PTPN13-like, Y-linked 2 5 1 0 1 0 0 hsa-miR-4498 -0.32 -0.32 N/A

DUSP9 ENST00000370167.4 dual specificity phosphatase 9 3766 1 1 0 0 0 hsa-miR-5001-5p -0.31 -0.32 N/A

RASSF6 ENST00000307439.5 Ras association (RalGDS/AF-6) domain family member 6 11 3 1 1 1 2 hsa-miR-5001-5p -0.31 -0.4 N/A UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- GALNT9 ENST00000397325.2 5 1 0 1 0 2 hsa-miR-4498 -0.31 -0.31 N/A acetylgalactosaminyltransferase 9 (GalNAc-T9) GP9 ENST00000307395.4 glycoprotein IX (platelet) 5 1 0 0 1 0 hsa-miR-5001-5p -0.31 -0.31 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score KRT85 ENST00000257901.3 keratin 85 5 1 0 1 0 2 hsa-miR-4498 -0.31 -0.31 N/A

SLAMF1 ENST00000302035.6 signaling lymphocytic activation molecule family member 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

WASF2 ENST00000536657.1 WAS protein family, member 2 311 4 0 2 2 0 hsa-miR-5001-5p -0.31 -0.32 N/A

RAPGEFL1 ENST00000264644.6 Rap guanine nucleotide exchange factor (GEF)-like 1 20 1 0 1 0 3 hsa-miR-4498 -0.31 -0.31 N/A

CNPY4 ENST00000262932.3 canopy FGF signaling regulator 4 24 1 0 1 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

NOS1 ENST00000317775.6 nitric oxide synthase 1 (neuronal) 5 1 0 1 0 2 hsa-miR-4498 -0.31 -0.31 N/A

TREML4 ENST00000341495.2 triggering receptor expressed on myeloid cells-like 4 5 1 0 1 0 1 hsa-miR-5001-5p -0.31 -0.31 N/A

PTPN7 ENST00000367279.4 protein tyrosine phosphatase, non-receptor type 7 5 1 1 0 0 1 hsa-miR-5001-5p -0.31 -0.31 N/A

LAS1L ENST00000312391.8 LAS1-like (S. cerevisiae) 26 2 0 1 1 2 hsa-miR-4498 -0.31 -0.39 N/A

TM2D3 ENST00000347970.3 TM2 domain containing 3 458 1 1 0 0 0 hsa-miR-4498 -0.31 -0.65 N/A

CAPN13 ENST00000295055.8 calpain 13 5 1 0 1 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

CDIP1 ENST00000564828.1 cell death-inducing p53 target 1 1857 2 0 2 0 0 hsa-miR-4498 -0.31 -0.48 N/A

PFKFB4 ENST00000232375.3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 16 2 1 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

LEPRE1 ENST00000236040.4 leucine proline-enriched proteoglycan (leprecan) 1 4638 2 0 1 1 1 hsa-miR-5001-5p -0.31 -0.31 N/A SWI/SNF related, matrix associated, actin dependent SMARCD2 ENST00000448276.2 144 2 0 1 1 0 hsa-miR-5001-5p -0.31 -0.31 N/A regulator of chromatin, subfamily d, member 2 PCSK1N ENST00000218230.5 proprotein convertase subtilisin/kexin type 1 inhibitor 13 1 0 1 0 0 hsa-miR-762 -0.31 -0.31 N/A

TNNT3 ENST00000278317.6 troponin T type 3 (skeletal, fast) 5 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

ADAMTSL3 ENST00000286744.5 ADAMTS-like 3 9 1 1 0 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

CROCC ENST00000375541.5 ciliary rootlet coiled-coil, rootletin 136 1 0 1 0 2 hsa-miR-4498 -0.31 -0.31 N/A

GUCD1 ENST00000447813.2 guanylyl cyclase domain containing 1 2990 1 0 0 1 3 hsa-miR-5001-5p -0.31 -0.31 N/A

MDK ENST00000359803.3 midkine (neurite growth-promoting factor 2) 3536 1 0 1 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

CEACAM19 ENST00000358777.4 carcinoembryonic antigen-related cell adhesion molecule 19 11 2 0 2 0 2 hsa-miR-4498 -0.31 -0.34 N/A

RPS9 ENST00000441429.1 ribosomal protein S9 54 1 0 1 0 1 hsa-miR-4498 -0.31 -0.31 N/A

MGC4294 ENST00000598340.1 HCG1785561; MGC4294 protein; Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

ZNF385A ENST00000551109.1 zinc finger protein 385A 94 2 0 2 0 0 hsa-miR-4498 -0.31 -0.31 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF575 ENST00000458714.2 zinc finger protein 575 28 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

RASA4 ENST00000262940.7 RAS p21 protein activator 4 5 3 1 2 0 2 hsa-miR-4498 -0.31 -0.31 N/A Esophagus cancer-related gene-2 interaction susceptibility AL117190.3 ENST00000599197.1 30 2 0 2 0 2 hsa-miR-4498 -0.31 -0.38 N/A protein; Uncharacterized protein ZFYVE28 ENST00000508471.1 zinc finger, FYVE domain containing 28 18 3 0 2 1 7 hsa-miR-4498 -0.31 -0.39 N/A

CARD11 ENST00000396946.4 caspase recruitment domain family, member 11 13 3 0 2 1 2 hsa-miR-5001-5p -0.31 -0.48 N/A

RAB7A ENST00000265062.3 RAB7A, member RAS oncogene family 7894 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

DNASE1L1 ENST00000369809.1 deoxyribonuclease I-like 1 16 1 0 1 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

ZNF253 ENST00000589717.1 zinc finger protein 253 25 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

UBFD1 ENST00000395878.3 ubiquitin family domain containing 1 6826 1 1 0 0 1 hsa-miR-5001-5p -0.31 -0.32 N/A

CCDC134 ENST00000255784.5 coiled-coil domain containing 134 15 3 0 3 0 1 hsa-miR-4498 -0.31 -0.65 N/A

C4orf26 ENST00000311623.4 chromosome 4 open reading frame 26 5 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

PNOC ENST00000301908.3 prepronociceptin 13 1 0 1 0 1 hsa-miR-4498 -0.31 -0.31 N/A

ZNF429 ENST00000358491.4 zinc finger protein 429 23 1 1 0 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

KRTAP5-9 ENST00000528743.2 keratin associated protein 5-9 5 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

DMKN ENST00000472252.2 dermokine 660 3* 0 1 1 2 hsa-miR-4498 -0.31 -0.44 N/A

TMC6 ENST00000590602.1 transmembrane channel-like 6 11 18 2 13 3 1 hsa-miR-4498 -0.31 -0.8 N/A

CEBPA ENST00000498907.2 CCAAT/enhancer binding protein (C/EBP), alpha 12449 2 0 2 0 0 hsa-miR-4498 -0.31 -0.31 N/A

STXBP1 ENST00000373302.3 syntaxin binding protein 1 295 2 0 2 0 0 hsa-miR-4498 -0.31 -0.33 N/A

FBXO2 ENST00000354287.4 F-box protein 2 767 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A potassium intermediate/small conductance calcium-activated KCNN4 ENST00000262888.3 142 1 0 1 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A channel, subfamily N, member 4 APCDD1 ENST00000355285.5 adenomatosis polyposis coli down-regulated 1 83 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

HYAL1 ENST00000395144.2 hyaluronoglucosaminidase 1 59 1 0 1 0 1 hsa-miR-4498 -0.31 -0.31 N/A

LCP1 ENST00000398576.2 lymphocyte cytosolic protein 1 (L-plastin) 7 1 1 0 0 0 hsa-miR-5001-5p -0.31 -0.31 N/A

WDR52 ENST00000393845.2 WD repeat domain 52 5 3 0 2 1 1 hsa-miR-5001-5p -0.31 -0.31 N/A

AC007952.6 ENST00000399083.1 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FBXO17 ENST00000292852.4 F-box protein 17 5 1 0 0 1 1 hsa-miR-5001-5p -0.31 -0.31 N/A

VTI1A ENST00000393077.2 vesicle transport through interaction with t-SNAREs 1A 376 2 0 2 0 0 hsa-miR-4498 -0.31 -0.38 N/A guanine nucleotide binding protein (G protein), alpha GNAT1 ENST00000232461.3 8 3 0 2 1 3 hsa-miR-4498 -0.31 -0.41 N/A transducing activity polypeptide 1 PKNOX2 ENST00000298282.9 PBX/knotted 1 homeobox 2 46 2 0 2 0 2 hsa-miR-5001-5p -0.31 -0.34 N/A

HIP1R ENST00000253083.4 huntingtin interacting protein 1 related 17 2 0 2 0 1 hsa-miR-4498 -0.31 -0.31 N/A

MAP2K7 ENST00000397981.3 mitogen-activated protein kinase kinase 7 164 2 1 1 0 0 hsa-miR-4498 -0.31 -0.31 N/A

C19orf57 ENST00000586783.1 chromosome 19 open reading frame 57 66 1 0 1 0 1 hsa-miR-4498 -0.31 -0.31 N/A

LPHN1 ENST00000340736.6 latrophilin 1 49 7 1 4 2 1 hsa-miR-4498 -0.31 -0.44 N/A

UNC13D ENST00000207549.4 unc-13 homolog D (C. elegans) 20 2 0 2 0 0 hsa-miR-4498 -0.31 -0.37 N/A

DLGAP4 ENST00000373913.3 discs, large (Drosophila) homolog-associated protein 4 1188 2 0 2 0 2 hsa-miR-4498 -0.31 -0.33 N/A

PGPEP1 ENST00000597431.2 pyroglutamyl-peptidase I 82 3 1 2 0 1 hsa-miR-5001-5p -0.31 -0.69 N/A sarcoglycan, alpha (50kDa dystrophin-associated SGCA ENST00000262018.3 14 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A glycoprotein) IL10 ENST00000423557.1 interleukin 10 5 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

GLIS2 ENST00000262366.3 GLIS family zinc finger 2 17 4 1 3 0 1 hsa-miR-5001-5p -0.3 -0.3 N/A

AC007952.5 ENST00000399091.1 Uncharacterized protein ENSP00000382042 5 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

ARHGEF4 ENST00000392953.3 Rho guanine nucleotide exchange factor (GEF) 4 189 5 0 3 2 0 hsa-miR-5001-5p -0.3 -0.3 N/A

FAM132B ENST00000546354.1 family with sequence similarity 132, member B 722 2 0 1 1 0 hsa-miR-5001-5p -0.3 -0.3 N/A

CD79B ENST00000392795.3 CD79b molecule, immunoglobulin-associated beta 5 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

SLC35A4 ENST00000323146.3 solute carrier family 35, member A4 334 1 1 0 0 1 hsa-miR-5001-5p -0.3 -0.3 N/A

PPP2R5B ENST00000164133.2 protein phosphatase 2, regulatory subunit B', beta 23 1 1 0 0 1 hsa-miR-5001-5p -0.3 -0.3 N/A

NUDT8 ENST00000301490.4 nudix (nucleoside diphosphate linked moiety X)-type motif 8 434 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

CD1B ENST00000368168.3 CD1b molecule 5 1 0 0 1 0 hsa-miR-5001-5p -0.3 -0.3 N/A

LGI2 ENST00000382114.4 leucine-rich repeat LGI family, member 2 32 2 1 0 1 0 hsa-miR-5001-5p -0.3 -0.3 N/A

IFNLR1 ENST00000327575.2 interferon, lambda receptor 1 15 1 0 1 0 1 hsa-miR-5001-5p -0.3 -0.3 N/A solute carrier family 5 (sodium/iodide cotransporter), SLC5A5 ENST00000222248.3 5 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A member 5 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MAP1S ENST00000324096.4 microtubule-associated protein 1S 45 1 0 0 1 0 hsa-miR-5001-5p -0.3 -0.3 N/A

TESPA1 ENST00000524622.1 thymocyte expressed, positive selection associated 1 5 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A pleckstrin homology domain containing, family M (with PLEKHM1 ENST00000430334.3 90 1 0 0 1 0 hsa-miR-4498 -0.3 -0.3 N/A RUN domain) member 1 RNF121 ENST00000393713.3 ring finger protein 121 610 2 0 1 1 0 hsa-miR-5001-5p -0.3 -0.31 N/A

OSER1 ENST00000372970.2 oxidative stress responsive serine-rich 1 1082 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.55 N/A

C2orf72 ENST00000373640.4 chromosome 2 open reading frame 72 3885 6 2 4 0 1 hsa-miR-4498 -0.3 -0.59 N/A

SORBS3 ENST00000240123.7 sorbin and SH3 domain containing 3 1126 1 0 1 0 2 hsa-miR-5001-5p -0.3 -0.36 N/A

TMUB2 ENST00000590235.1 transmembrane and ubiquitin-like domain containing 2 1043 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

ZSCAN18 ENST00000240727.6 zinc finger and SCAN domain containing 18 838 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

MYADML2 ENST00000409745.2 myeloid-associated differentiation marker-like 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.3 -0.3 N/A

ATCAY ENST00000450849.2 ataxia, cerebellar, Cayman type 5 2 0 1 1 1 hsa-miR-5001-5p -0.3 -0.3 N/A

HPR ENST00000561690.1 haptoglobin-related protein 5 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

ZNF275 ENST00000370251.3 zinc finger protein 275 465 3 1 1 1 3 hsa-miR-5001-5p -0.3 -0.31 N/A

FSTL3 ENST00000166139.4 follistatin-like 3 (secreted glycoprotein) 207 4 1 2 1 1 hsa-miR-4498 -0.3 -0.95 N/A

TMPRSS6 ENST00000381792.2 transmembrane protease, serine 6 69 2 0 1 1 1 hsa-miR-4498 -0.3 -0.3 N/A

CD1E ENST00000368161.3 CD1e molecule 5 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

KCNE1L ENST00000372101.2 KCNE1-like 9 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

LRP1 ENST00000243077.3 low density lipoprotein receptor-related protein 1 270 2 0 2 0 1 hsa-miR-4498 -0.3 -0.41 N/A

GPRC5A ENST00000014914.5 G protein-coupled receptor, family C, group 5, member A 341 4 0 1 3 0 hsa-miR-5001-5p -0.3 -0.37 N/A

MSLN ENST00000566549.1 mesothelin 117 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

ART5 ENST00000397067.3 ADP-ribosyltransferase 5 50 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

MAPT ENST00000344290.5 microtubule-associated protein tau 11 1 0 0 1 2 hsa-miR-5001-5p -0.3 -0.3 N/A

SCD5 ENST00000319540.4 stearoyl-CoA desaturase 5 1181 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

CAMLG ENST00000514518.1 calcium modulating ligand 458 1 0 1 0 0 hsa-miR-4498 -0.3 -0.33 N/A

GRK6 ENST00000393576.3 G protein-coupled receptor kinase 6 130 7 0 5 2 1 hsa-miR-4498 -0.3 -0.72 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score KDM8 ENST00000380948.2 lysine (K)-specific demethylase 8 62 1 0 1 0 1 hsa-miR-4498 -0.3 -0.33 N/A

PDGFRB ENST00000261799.4 platelet-derived growth factor receptor, beta polypeptide 320 3 1 1 1 1 hsa-miR-5001-5p -0.3 -0.3 N/A

ZSWIM3 ENST00000255152.2 zinc finger, SWIM-type containing 3 52 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

FAM195A ENST00000307650.4 family with sequence similarity 195, member A 7 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

RBM10 ENST00000345781.6 RNA binding motif protein 10 1186 1 1 0 0 0 hsa-miR-4498 -0.3 -0.3 N/A

CCDC113 ENST00000443128.2 coiled-coil domain containing 113 29 2 1 0 1 2 hsa-miR-5001-5p -0.3 -0.36 N/A

MPV17L2 ENST00000599612.2 MPV17 mitochondrial membrane protein-like 2 18 1 0 1 0 1 hsa-miR-5001-5p -0.3 -0.32 N/A

USF2 ENST00000594064.1 upstream transcription factor 2, c-fos interacting 1981 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

RIPK1 ENST00000380409.2 receptor (TNFRSF)-interacting serine-threonine kinase 1 20 3 0 1 2 0 hsa-miR-4498 -0.3 -0.53 N/A

SHISA6 ENST00000441885.3 shisa family member 6 5 2 0 2 0 3 hsa-miR-4498 -0.3 -0.3 N/A

TMEM134 ENST00000393877.3 transmembrane protein 134 826 6 1 5 0 2 hsa-miR-5001-5p -0.3 -1.57 N/A

CLTB ENST00000310418.4 clathrin, light chain B 3715 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

MAPK15 ENST00000338033.4 mitogen-activated protein kinase 15 10 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

GPR61 ENST00000527748.1 G protein-coupled receptor 61 5 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

ALDH3B2 ENST00000530069.1 aldehyde dehydrogenase 3 family, member B2 5 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

NECAB2 ENST00000305202.4 N-terminal EF-hand calcium binding protein 2 7 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

CREB3L1 ENST00000529193.1 cAMP responsive element binding protein 3-like 1 160 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

PLXNA4 ENST00000321063.4 plexin A4 9 7 1 3 3 3 hsa-miR-5001-5p -0.3 -0.4 N/A

KIF1C ENST00000320785.5 kinesin family member 1C 149 1 0 1 0 1 hsa-miR-4498 -0.3 -0.35 N/A

TBX10 ENST00000335385.3 T-box 10 5 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

POR ENST00000394893.1 P450 (cytochrome) oxidoreductase 3417 3 0 2 1 1 hsa-miR-5001-5p -0.3 -0.3 N/A

TM7SF2 ENST00000540748.1 transmembrane 7 superfamily member 2 667 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

CACFD1 ENST00000291722.7 calcium channel flower domain containing 1 1315 2 0 2 0 2 hsa-miR-4498 -0.3 -0.3 N/A Homo sapiens coiled-coil domain containing 177 CCDC177 ENST00000599174.1 0 2 0 2 0 1 hsa-miR-4498 -0.3 -0.3 N/A (CCDC177), mRNA. AMMECR1L ENST00000272647.5 AMMECR1-like 21 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CCDC116 ENST00000292779.3 coiled-coil domain containing 116 7 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

PLEKHA6 ENST00000272203.3 pleckstrin homology domain containing, family A member 6 45 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

ANKRD40 ENST00000285243.6 ankyrin repeat domain 40 409 2 1 1 0 0 hsa-miR-5001-5p -0.3 -0.35 N/A

MAST3 ENST00000262811.6 microtubule associated serine/threonine kinase 3 46 2 0 1 1 0 hsa-miR-5001-5p -0.3 -0.47 N/A

ARHGEF40 ENST00000298694.4 Rho guanine nucleotide exchange factor (GEF) 40 383 3 0 2 1 0 hsa-miR-4498 -0.3 -0.55 N/A

BBS10 ENST00000393262.3 Bardet-Biedl syndrome 10 186 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

FAM153C ENST00000398106.2 family with sequence similarity 153, member C 5 2 0 1 1 1 hsa-miR-5001-5p -0.3 -0.3 N/A

NKX2-1 ENST00000354822.5 NK2 homeobox 1 9 1 0 1 0 1 hsa-miR-4498 -0.3 -0.3 N/A

KCNK6 ENST00000263372.3 potassium channel, subfamily K, member 6 137 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

TPPP3 ENST00000393957.2 tubulin polymerization-promoting protein family member 3 5 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

RP11-93B14.6 ENST00000370520.3 HCG2018282; Uncharacterized protein 5 1 0 1 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

VPS4A ENST00000254950.11 vacuolar protein sorting 4 homolog A (S. cerevisiae) 430 1 1 0 0 1 hsa-miR-5001-5p -0.3 -0.32 N/A solute carrier family 9, subfamily A (NHE3, cation proton SLC9A3R2 ENST00000424542.2 432 1 0 1 0 2 hsa-miR-4498 -0.3 -0.31 N/A antiporter 3), member 3 regulator 2 NDRG4 ENST00000258187.5 NDRG family member 4 68 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.31 N/A

SHF ENST00000560540.1 Src homology 2 domain containing F 112 1 0 1 0 2 hsa-miR-5001-5p -0.3 -0.34 N/A

KNDC1 ENST00000304613.3 kinase non-catalytic C-lobe domain (KIND) containing 1 5 1 1 0 0 2 hsa-miR-5001-5p -0.3 -0.3 N/A

EPOR ENST00000592375.2 erythropoietin receptor 96 1 1 0 0 0 hsa-miR-5001-5p -0.3 -0.3 N/A

RBFOX3 ENST00000583458.1 RNA binding protein, fox-1 homolog (C. elegans) 3 5 2 0 2 0 0 hsa-miR-4498 -0.3 -0.3 N/A

BMP8B ENST00000372827.3 bone morphogenetic protein 8b 88 1 1 0 0 4 hsa-miR-5001-5p -0.3 -0.3 N/A

PPM1J ENST00000309276.6 protein phosphatase, Mg2+/Mn2+ dependent, 1J 89 1 0 0 1 0 hsa-miR-5001-5p -0.3 -0.3 N/A

IRF5 ENST00000402030.2 interferon regulatory factor 5 7 1 1 0 0 1 hsa-miR-5001-5p -0.3 -0.39 N/A

TRIM11 ENST00000493030.2 tripartite motif containing 11 727 4 0 4 0 2 hsa-miR-4498 -0.3 -0.55 N/A

NKX2-8 ENST00000258829.5 NK2 homeobox 8 75 2 0 1 1 1 hsa-miR-5001-5p -0.3 -0.38 N/A

AGTR2 ENST00000371906.4 angiotensin II receptor, type 2 5 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

NINJ2 ENST00000305108.4 ninjurin 2 11 1 0 0 1 0 hsa-miR-4498 -0.3 -0.3 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CPSF7 ENST00000340437.4 cleavage and polyadenylation specific factor 7, 59kDa 1283 1 0 1 0 0 hsa-miR-4498 -0.3 -0.3 N/A

TMIE ENST00000326431.3 transmembrane inner ear 26 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

AMER1 ENST00000330258.3 APC membrane recruitment protein 1 11 2 1 1 0 2 hsa-miR-4498 -0.29 -0.29 N/A

CUX1 ENST00000437600.4 cut-like homeobox 1 1205 1 0 1 0 1 hsa-miR-4498 -0.29 -0.29 N/A

DHCR24 ENST00000371269.3 24-dehydrocholesterol reductase 7645 2 0 0 2 1 hsa-miR-5001-5p -0.29 -0.29 N/A

SLCO3A1 ENST00000318445.6 solute carrier organic anion transporter family, member 3A1 133 3 0 2 1 0 hsa-miR-4498 -0.29 -0.4 N/A

ICOSLG ENST00000407780.3 inducible T-cell co-stimulator ligand 47 5 1 1 3 7 hsa-miR-4498 -0.29 -0.81 N/A

GPBP1L1 ENST00000290795.3 GC-rich promoter binding protein 1-like 1 1737 1 0 1 0 0 hsa-miR-4498 -0.29 -0.31 N/A

SIGLEC14 ENST00000360844.6 sialic acid binding Ig-like lectin 14 5 2 0 1 1 0 hsa-miR-5001-5p -0.29 -0.39 N/A

TMEM109 ENST00000227525.3 transmembrane protein 109 4675 1 0 1 0 3 hsa-miR-4498 -0.29 -0.29 N/A

MAT1A ENST00000372213.3 methionine adenosyltransferase I, alpha 19 3 0 2 1 0 hsa-miR-4498 -0.29 -0.29 N/A

SCRT2 ENST00000246104.6 scratch homolog 2, zinc finger protein (Drosophila) 5 2 0 2 0 0 hsa-miR-4498 -0.29 -0.29 N/A

ECE2 ENST00000324557.4 endothelin converting enzyme 2 1271 1 0 0 1 0 hsa-miR-5001-5p -0.29 -0.29 N/A

HOXB1 ENST00000239174.6 homeobox B1 5 2 0 1 1 0 hsa-miR-4498 -0.29 -0.29 N/A

ZBTB16 ENST00000335953.4 zinc finger and BTB domain containing 16 73 5 1 3 1 0 hsa-miR-5001-5p -0.29 -0.32 N/A

NXPH3 ENST00000328741.5 neurexophilin 3 65 6 0 2 4 1 hsa-miR-5001-5p -0.29 -0.5 N/A

LARP1 ENST00000336314.4 La ribonucleoprotein domain family, member 1 4979 2 1 0 1 4 hsa-miR-5001-5p -0.29 -0.29 N/A

GID8 ENST00000266069.3 GID complex subunit 8 515 1 0 1 0 1 hsa-miR-4498 -0.29 -0.29 N/A

MRPL28 ENST00000199706.8 mitochondrial ribosomal protein L28 10643 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

PDE6G ENST00000573076.1 phosphodiesterase 6G, cGMP-specific, rod, gamma 6 2 0 2 0 0 hsa-miR-4498 -0.29 -0.29 N/A

CCDC27 ENST00000294600.2 coiled-coil domain containing 27 5 1 0 0 1 0 hsa-miR-5001-5p -0.29 -0.29 N/A

RNASE11 ENST00000610205.1 ribonuclease, RNase A family, 11 (non-active) 5 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

TOR4A ENST00000357503.2 torsin family 4, member A 222 2 0 1 1 3 hsa-miR-5001-5p -0.29 -0.29 N/A BRF1, RNA polymerase III transcription initiation factor 90 BRF1 ENST00000392557.4 199 1 1 0 0 2 hsa-miR-5001-5p -0.29 -0.29 N/A kDa subunit SPIB ENST00000595883.1 Spi-B transcription factor (Spi-1/PU.1 related) 10 2 1 1 0 1 hsa-miR-4498 -0.29 -0.53 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score STC1 ENST00000290271.2 stanniocalcin 1 2932 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.3 N/A

IL10RA ENST00000227752.3 interleukin 10 receptor, alpha 5 2 0 1 1 5 hsa-miR-4498 -0.29 -0.56 N/A solute carrier family 34 (type II sodium/phosphate SLC34A1 ENST00000324417.5 5 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A contransporter), member 1 AWAT1 ENST00000374521.3 acyl-CoA wax alcohol acyltransferase 1 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

ATXN7L1 ENST00000419735.3 ataxin 7-like 1 67 2 0 1 1 0 hsa-miR-5001-5p -0.29 -0.29 N/A

CXorf36 ENST00000398000.2 chromosome X open reading frame 36 5 2 0 2 0 1 hsa-miR-4498 -0.29 -0.29 N/A membrane-associated ring finger (C3HC4) 10, E3 ubiquitin MARCH10 ENST00000456609.2 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A protein ligase SOCS3 ENST00000330871.2 suppressor of cytokine signaling 3 5 2 1 0 1 1 hsa-miR-4498 -0.29 -0.29 N/A HCG2018772; Uncharacterized protein; cDNA FLJ31609 AL031666.2 ENST00000599904.1 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A fis, clone NT2RI2002852 CNTROB ENST00000380255.3 centrobin, centrosomal BRCA2 interacting protein 338 1 0 1 0 1 hsa-miR-4498 -0.29 -0.29 N/A

VPS37C ENST00000301765.5 vacuolar protein sorting 37 homolog C (S. cerevisiae) 3267 2 1 1 0 2 hsa-miR-5001-5p -0.29 -0.29 N/A

GDF6 ENST00000287020.5 growth differentiation factor 6 14 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

GPA33 ENST00000367868.3 glycoprotein A33 (transmembrane) 5 1 1 0 0 1 hsa-miR-5001-5p -0.29 -0.29 N/A

RPL37 ENST00000274242.5 ribosomal protein L37 1785 1 0 1 0 2 hsa-miR-4498 -0.29 -0.34 N/A

PRKCA ENST00000413366.3 protein kinase C, alpha 726 3 0 2 1 4 hsa-miR-4498 -0.29 -0.3 N/A

MATN1 ENST00000373765.4 matrilin 1, cartilage matrix protein 5 2 0 2 0 1 hsa-miR-4498 -0.29 -0.29 N/A

CTD-2260A17.2 ENST00000504056.1 Uncharacterized protein 5 1 0 0 1 0 hsa-miR-4498 -0.29 -0.29 N/A

MID2 ENST00000262843.6 midline 2 194 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.38 N/A

TANGO2 ENST00000434570.2 transport and golgi organization 2 homolog (Drosophila) 119 2 0 2 0 3 hsa-miR-4498 -0.29 -0.43 N/A

HRAS ENST00000397594.1 Harvey rat sarcoma viral oncogene homolog 420 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

AK8 ENST00000298545.3 adenylate kinase 8 7 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

HP ENST00000562526.1 haptoglobin 5 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

BCAN ENST00000329117.5 brevican 11 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

NAP1L4 ENST00000380542.4 nucleosome assembly protein 1-like 4 7751 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

TXLNA ENST00000373610.3 taxilin alpha 564 4 0 2 2 0 hsa-miR-5001-5p -0.29 -0.29 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RGL2 ENST00000497454.1 ral guanine nucleotide dissociation stimulator-like 2 150 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

RSPRY1 ENST00000394420.4 ring finger and SPRY domain containing 1 735 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A solute carrier family 23 (ascorbic acid transporter), member SLC23A1 ENST00000353963.3 19 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A 1 UBASH3B ENST00000284273.5 ubiquitin associated and SH3 domain containing B 281 1 0 1 0 1 hsa-miR-4498 -0.29 -0.32 N/A

TGFBR3 ENST00000212355.4 transforming growth factor, beta receptor III 245 2 1 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

PRR20A ENST00000377931.1 proline rich 20A 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

PRR20E ENST00000434815.1 proline rich 20E 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

PRDX5 ENST00000265462.4 peroxiredoxin 5 71116 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A single-strand-selective monofunctional uracil-DNA SMUG1 ENST00000505128.1 242 2 0 1 1 1 hsa-miR-5001-5p -0.29 -0.29 N/A glycosylase 1 DOLPP1 ENST00000540102.1 dolichyldiphosphatase 1 963 2 0 2 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

PRR20C ENST00000544357.2 proline rich 20C 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

PRR20B ENST00000377930.1 proline rich 20B 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

CD96 ENST00000352690.4 CD96 molecule 5 1 0 0 1 1 hsa-miR-5001-5p -0.29 -0.29 N/A

PRR20D ENST00000452123.3 proline rich 20D 5 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

LZTR1 ENST00000215739.8 leucine-zipper-like transcription regulator 1 356 1 0 0 1 1 hsa-miR-5001-5p -0.29 -0.31 N/A

HPSE2 ENST00000370546.1 heparanase 2 12 2 0 2 0 1 hsa-miR-5001-5p -0.29 -0.35 N/A

CDCA8 ENST00000373055.1 cell division cycle associated 8 1689 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

CHRM1 ENST00000306960.3 cholinergic receptor, muscarinic 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.29 -0.29 N/A

SH3GL1 ENST00000269886.3 SH3-domain GRB2-like 1 739 1 0 1 0 3 hsa-miR-5001-5p -0.29 -0.29 N/A small glutamine-rich tetratricopeptide repeat (TPR)- SGTA ENST00000221566.2 250 1 0 1 0 2 hsa-miR-4498 -0.29 -0.29 N/A containing, alpha transient receptor potential cation channel, subfamily M, TRPM3 ENST00000377110.3 11 2 0 1 1 0 hsa-miR-5001-5p -0.29 -0.29 N/A member 3 MXRA8 ENST00000445648.2 matrix-remodelling associated 8 216 1 0 1 0 2 hsa-miR-4498 -0.29 -0.29 N/A NMDA receptor synaptonuclear signaling and neuronal NSMF ENST00000339554.3 507 2 0 0 2 1 hsa-miR-762 -0.29 -0.29 N/A migration factor CCRL2 ENST00000399036.3 chemokine (C-C motif) receptor-like 2 5 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A potassium voltage-gated channel, Shal-related subfamily, KCND3 ENST00000369697.1 23 1 1 0 0 1 hsa-miR-4498 -0.29 -0.29 N/A member 3 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SEPT9 ENST00000431235.2 septin 9 7738 1 0 0 1 1 hsa-miR-5001-5p -0.29 -0.29 N/A

LINGO1 ENST00000355300.6 leucine rich repeat and Ig domain containing 1 42 2 0 2 0 0 hsa-miR-4498 -0.29 -0.34 N/A

TCEA2 ENST00000395053.3 transcription elongation factor A (SII), 2 181 1 0 1 0 1 hsa-miR-4498 -0.29 -0.29 N/A

ZNF578 ENST00000421239.2 zinc finger protein 578 0 1 1 0 0 2 hsa-miR-5001-5p -0.29 -0.29 N/A lecithin retinol acyltransferase (phosphatidylcholine--retinol LRAT ENST00000336356.3 9 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A O-acyltransferase) HBZ ENST00000252951.2 hemoglobin, zeta 7 1 0 1 0 0 hsa-miR-4498 -0.29 -0.29 N/A

RPS6KA1 ENST00000374168.2 ribosomal protein S6 kinase, 90kDa, polypeptide 1 1449 1 1 0 0 1 hsa-miR-5001-5p -0.29 -0.29 N/A

CHMP4A ENST00000347519.6 charged multivesicular body protein 4A 564 1 0 1 0 0 hsa-miR-4498 -0.29 -0.34 N/A

SYNJ1 ENST00000357345.3 synaptojanin 1 143 3 0 2 1 0 hsa-miR-5001-5p -0.29 -0.32 N/A

GPR56 ENST00000388812.4 G protein-coupled receptor 56 44 2 0 2 0 1 hsa-miR-4498 -0.29 -0.29 N/A

SPTBN5 ENST00000320955.6 spectrin, beta, non-erythrocytic 5 7 1 0 1 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

AHCYL1 ENST00000369799.5 adenosylhomocysteinase-like 1 1279 1 1 0 0 0 hsa-miR-5001-5p -0.29 -0.29 N/A

TNS1 ENST00000171887.4 tensin 1 591 3 0 2 1 2 hsa-miR-4498 -0.29 -0.29 N/A

LLGL1 ENST00000316843.4 lethal giant larvae homolog 1 (Drosophila) 328 2 0 2 0 0 hsa-miR-4498 -0.29 -0.29 N/A

SGSM2 ENST00000426855.2 small G protein signaling modulator 2 381 7 2 3 2 3 hsa-miR-4498 -0.29 -0.45 N/A

FADS2 ENST00000257261.6 fatty acid desaturase 2 285 4 2 1 1 0 hsa-miR-5001-5p -0.29 -0.59 N/A

NOX5 ENST00000260364.5 NADPH oxidase, EF-hand calcium binding domain 5 5 1 1 0 0 1 hsa-miR-4498 -0.28 -0.28 N/A

BARX1 ENST00000253968.6 BARX homeobox 1 10 1 0 1 0 1 hsa-miR-5001-5p -0.28 -0.28 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS14 ENST00000373208.1 5 2 1 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A 14 QRICH2 ENST00000262765.5 glutamine rich 2 47 1 0 0 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A nudix (nucleoside diphosphate linked moiety X)-type motif NUDT16L1 ENST00000405142.1 2062 1 1 0 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A 16-like 1 PLEC ENST00000345136.3 plectin 7 6 1 5 0 0 hsa-miR-4498 -0.28 -0.28 N/A

AMER3 ENST00000423981.1 APC membrane recruitment protein 3 5 1 0 0 1 2 hsa-miR-5001-5p -0.28 -0.28 N/A

TTC7A ENST00000319190.5 tetratricopeptide repeat domain 7A 400 2 1 1 0 2 hsa-miR-4498 -0.28 -0.29 N/A

NINJ1 ENST00000375446.4 ninjurin 1 1216 6 1 5 0 1 hsa-miR-762 -0.28 -1.11 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ANKRD53 ENST00000272421.6 ankyrin repeat domain 53 14 2 0 0 2 0 hsa-miR-5001-5p -0.28 -0.28 N/A

RNF165 ENST00000269439.7 ring finger protein 165 18 2 0 1 1 3 hsa-miR-5001-5p -0.28 -0.28 N/A

LCN1 ENST00000371781.3 lipocalin 1 5 1 0 0 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

IL10RB ENST00000290200.2 interleukin 10 receptor, beta 238 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

GSG1 ENST00000396302.3 germ cell associated 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.28 -0.28 N/A

KIF3C ENST00000264712.3 kinesin family member 3C 177 1 0 1 0 3 hsa-miR-4498 -0.28 -0.28 N/A

MCRS1 ENST00000546244.1 microspherule protein 1 914 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

SYNGR1 ENST00000328933.5 synaptogyrin 1 101 2 0 1 1 4 hsa-miR-5001-5p -0.28 -0.28 N/A

CYP20A1 ENST00000356079.4 cytochrome P450, family 20, subfamily A, polypeptide 1 170 4 2 1 1 1 hsa-miR-5001-5p -0.28 -1.4 N/A

GPR107 ENST00000372410.3 G protein-coupled receptor 107 1429 3 1 0 2 2 hsa-miR-5001-5p -0.28 -0.3 N/A

HRH3 ENST00000340177.5 histamine receptor H3 5 2 0 1 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

KIFAP3 ENST00000361580.2 kinesin-associated protein 3 42 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

MADD ENST00000406482.1 MAP-kinase activating death domain 282 1 1 0 0 1 hsa-miR-5001-5p -0.28 -0.28 N/A

RASL10B ENST00000268864.3 RAS-like, family 10, member B 1495 1 0 1 0 3 hsa-miR-5001-5p -0.28 -0.28 N/A

PLD2 ENST00000263088.6 phospholipase D2 57 1 1 0 0 1 hsa-miR-4498 -0.28 -0.28 N/A

TMEM133 ENST00000303130.2 transmembrane protein 133 543 1 1 0 0 0 hsa-miR-4498 -0.28 -0.28 N/A

ARMC6 ENST00000392335.2 armadillo repeat containing 6 1295 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A

USH1G ENST00000319642.1 Usher syndrome 1G (autosomal recessive) 5 2 0 2 0 3 hsa-miR-4498 -0.28 -0.28 N/A

ZNF787 ENST00000270459.3 zinc finger protein 787 191 1 0 0 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

BCAS3 ENST00000589222.1 breast carcinoma amplified sequence 3 339 4 0 4 0 1 hsa-miR-5001-5p -0.28 -0.32 N/A

LOXL3 ENST00000264094.3 lysyl oxidase-like 3 235 2 0 2 0 0 hsa-miR-5001-5p -0.28 -0.52 N/A

CNPY3 ENST00000394142.3 canopy FGF signaling regulator 3 837 1 0 1 0 4 hsa-miR-4498 -0.28 -0.38 N/A

ATP7B ENST00000242839.4 ATPase, Cu++ transporting, beta polypeptide 88 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A

STX10 ENST00000589083.1 syntaxin 10 389 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

ABHD12B ENST00000353130.1 abhydrolase domain containing 12B 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score HELZ2 ENST00000427522.2 helicase with zinc finger 2, transcriptional coactivator 692 2 0 0 2 0 hsa-miR-5001-5p -0.28 -0.28 N/A

ZCCHC16 ENST00000340433.2 zinc finger, CCHC domain containing 16 5 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

SNRNP70 ENST00000221448.5 small nuclear ribonucleoprotein 70kDa (U1) 1180 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

GAS2L1 ENST00000360113.2 growth arrest-specific 2 like 1 230 3 0 3 0 2 hsa-miR-5001-5p -0.28 -0.28 N/A

SLC22A14 ENST00000273173.4 solute carrier family 22, member 14 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A sema domain, immunoglobulin domain (Ig), short basic SEMA3F ENST00000002829.3 263 2 0 2 0 1 hsa-miR-4498 -0.28 -0.29 N/A domain, secreted, (semaphorin) 3F FZD10 ENST00000539839.1 frizzled family receptor 10 36 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A

DMRT2 ENST00000259622.6 doublesex and mab-3 related transcription factor 2 5 1 1 0 0 1 hsa-miR-4498 -0.28 -0.28 N/A

FAM46A ENST00000369754.3 family with sequence similarity 46, member A 899 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

MIEF2 ENST00000395704.4 mitochondrial elongation factor 2 29 2 1 1 0 2 hsa-miR-5001-5p -0.28 -0.5 N/A

MLST8 ENST00000301725.7 MTOR associated protein, LST8 homolog (S. cerevisiae) 493 1 1 0 0 1 hsa-miR-5001-5p -0.28 -0.29 N/A

PARVA ENST00000334956.8 parvin, alpha 1912 3 1 1 1 0 hsa-miR-5001-5p -0.28 -0.49 N/A

C2orf48 ENST00000381786.3 chromosome 2 open reading frame 48 32 1 0 1 0 3 hsa-miR-4498 -0.28 -0.34 N/A

CERS4 ENST00000559336.1 ceramide synthase 4 1182 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ST8SIA1 ENST00000396037.4 5 2 0 1 1 1 hsa-miR-5001-5p -0.28 -0.28 N/A 1 CRAMP1L ENST00000397412.3 Crm, cramped-like (Drosophila) 731 4 1 3 0 2 hsa-miR-5001-5p -0.28 -0.28 N/A

RAB34 ENST00000447716.1 RAB34, member RAS oncogene family 880 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

IL1B ENST00000263341.2 interleukin 1, beta 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A solute carrier family 1 (glial high affinity glutamate SLC1A3 ENST00000265113.4 34 1 1 0 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A transporter), member 3 PDLIM7 ENST00000356618.4 PDZ and LIM domain 7 (enigma) 390 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

RNF187 ENST00000305943.7 ring finger protein 187 13589 2 0 1 1 5 hsa-miR-5001-5p -0.28 -0.53 N/A

NEU3 ENST00000532963.1 sialidase 3 (membrane sialidase) 243 2 0 1 1 1 hsa-miR-5001-5p -0.28 -0.28 N/A

GBGT1 ENST00000372043.3 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 41 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A

LPL ENST00000311322.8 lipoprotein lipase 7658 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

R3HDM4 ENST00000361574.5 R3H domain containing 4 123 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CCDC97 ENST00000269967.3 coiled-coil domain containing 97 85 1 0 1 0 3 hsa-miR-4498 -0.28 -0.44 N/A

CTIF ENST00000256413.3 CBP80/20-dependent translation initiation factor 154 3 1 2 0 4 hsa-miR-4498 -0.28 -0.42 N/A

CABLES1 ENST00000256925.7 Cdk5 and Abl enzyme substrate 1 341 5 4 1 0 3 hsa-miR-5001-5p -0.28 -0.77 N/A Uncharacterized protein; cDNA FLJ43210 fis, clone AC007375.1 ENST00000600936.1 7 3 0 2 1 1 hsa-miR-4498 -0.28 -0.43 N/A FEBRA2020582 PSTPIP1 ENST00000558012.1 proline-serine-threonine phosphatase interacting protein 1 19 4* 0 1 2 1 hsa-miR-4498 -0.28 -0.41 N/A

B4GALNT3 ENST00000266383.5 beta-1,4-N-acetyl-galactosaminyl transferase 3 5 2 2 0 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

NHSL2 ENST00000540800.1 NHS-like 2 5 3 0 3 0 2 hsa-miR-4498 -0.28 -0.28 N/A

TBX6 ENST00000395224.2 T-box 6 23 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

CD300LG ENST00000317310.4 CD300 molecule-like family member g 5 2 0 2 0 1 hsa-miR-4498 -0.28 -0.28 N/A

FAM53B ENST00000337318.3 family with sequence similarity 53, member B 27 3 0 2 1 4 hsa-miR-4498 -0.28 -0.28 N/A

SDR16C5 ENST00000396721.2 short chain dehydrogenase/reductase family 16C, member 5 5 1 0 0 1 1 hsa-miR-5001-5p -0.28 -0.28 N/A

PEX26 ENST00000329627.7 peroxisomal biogenesis factor 26 157 7 1 4 2 4 hsa-miR-4498 -0.28 -0.93 N/A

ZBTB46 ENST00000245663.4 zinc finger and BTB domain containing 46 71 4 0 4 0 4 hsa-miR-4498 -0.28 -0.28 N/A

CD320 ENST00000537716.2 CD320 molecule 36 1 0 1 0 1 hsa-miR-5001-5p -0.28 -0.28 N/A

GDI1 ENST00000447750.2 GDP dissociation inhibitor 1 21 2 0 2 0 0 hsa-miR-4498 -0.28 -0.28 N/A

C12orf49 ENST00000261318.3 chromosome 12 open reading frame 49 673 2 0 2 0 3 hsa-miR-4498 -0.28 -0.6 N/A

CTSA ENST00000372484.3 cathepsin A 3915 1 0 0 1 1 hsa-miR-5001-5p -0.28 -0.28 N/A

CES4A ENST00000540947.2 carboxylesterase 4A 30 1 1 0 0 1 hsa-miR-5001-5p -0.28 -0.37 N/A

ANKS6 ENST00000375018.1 ankyrin repeat and sterile alpha motif domain containing 6 98 3 0 2 1 3 hsa-miR-4498 -0.28 -0.42 N/A

GM2A ENST00000357164.3 GM2 ganglioside activator 134 3 2 1 0 1 hsa-miR-5001-5p -0.28 -0.86 N/A

CTSL ENST00000343150.5 cathepsin L 4520 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A potassium voltage-gated channel, shaker-related subfamily, KCNAB2 ENST00000378097.1 67 2 1 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A beta member 2 trans-golgi network vesicle protein 23 homolog A (S. TVP23A ENST00000299866.8 5 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A cerevisiae) RTP4 ENST00000259030.2 receptor (chemosensory) transporter protein 4 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

CD200 ENST00000315711.8 CD200 molecule 5 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score transducin-like enhancer of split 2 (E(sp1) homolog, TLE2 ENST00000591529.1 29 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A Drosophila) NNAT ENST00000062104.2 neuronatin 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

APEX2 ENST00000374987.3 APEX nuclease (apurinic/apyrimidinic endonuclease) 2 972 1 0 1 0 1 hsa-miR-5001-5p -0.28 -0.28 N/A translocase of inner mitochondrial membrane 22 homolog TIMM22 ENST00000327158.4 290 4 2 2 0 0 hsa-miR-4498 -0.28 -0.77 N/A (yeast) NUDT5 ENST00000491614.1 nudix (nucleoside diphosphate linked moiety X)-type motif 5 808 2 0 1 1 0 hsa-miR-5001-5p -0.28 -0.29 N/A

LDLRAP1 ENST00000374338.4 low density lipoprotein receptor adaptor protein 1 111 1 0 1 0 1 hsa-miR-4498 -0.28 -0.28 N/A

HES7 ENST00000541682.2 hairy and enhancer of split 7 (Drosophila) 416 2 0 1 1 0 hsa-miR-4498 -0.28 -0.28 N/A

NR2F1 ENST00000327111.3 nuclear receptor subfamily 2, group F, member 1 26 1 0 0 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

SAPCD2 ENST00000409687.3 suppressor APC domain containing 2 22 3 0 0 3 3 hsa-miR-4498 -0.28 -0.28 N/A

FCRL1 ENST00000368176.3 Fc receptor-like 1 5 1 0 1 0 2 hsa-miR-4498 -0.28 -0.28 N/A membrane-associated ring finger (C3HC4) 8, E3 ubiquitin MARCH8 ENST00000453424.2 48 2 0 2 0 2 hsa-miR-4498 -0.28 -0.28 N/A protein ligase MYL9 ENST00000279022.2 myosin, light chain 9, regulatory 1779 3 0 3 0 2 hsa-miR-5001-5p -0.28 -0.45 N/A

FEM1A ENST00000269856.3 fem-1 homolog a (C. elegans) 57 2 0 1 1 4 hsa-miR-5001-5p -0.28 -0.58 N/A

CEP164 ENST00000278935.3 centrosomal protein 164kDa 79 1 0 0 1 1 hsa-miR-5001-5p -0.28 -0.29 N/A

TPSAB1 ENST00000338844.3 tryptase alpha/beta 1 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

SLFN13 ENST00000285013.6 schlafen family member 13 11 2 0 1 1 0 hsa-miR-4498 -0.28 -0.28 N/A

COX10 ENST00000261643.3 cytochrome c oxidase assembly homolog 10 (yeast) 72 2 1 1 0 0 hsa-miR-5001-5p -0.28 -0.33 N/A

KRTAP10-7 ENST00000380102.2 keratin associated protein 10-7 5 1 0 1 0 0 hsa-miR-762 -0.28 -0.28 N/A

PDE1B ENST00000243052.3 phosphodiesterase 1B, calmodulin-dependent 6 1 0 1 0 2 hsa-miR-4498 -0.28 -0.28 N/A

PDE6A ENST00000255266.5 phosphodiesterase 6A, cGMP-specific, rod, alpha 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

NCLN ENST00000246117.4 nicalin 442 4 2 2 0 0 hsa-miR-4498 -0.28 -0.46 N/A

SFXN1 ENST00000321442.5 sideroflexin 1 1018 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.29 N/A

GIT1 ENST00000579937.1 G protein-coupled receptor kinase interacting ArfGAP 1 18 3 0 3 0 1 hsa-miR-4498 -0.28 -0.36 N/A

PHKG2 ENST00000563588.1 phosphorylase kinase, gamma 2 (testis) 283 3 1 2 0 0 hsa-miR-4498 -0.28 -0.4 N/A

SYNGR2 ENST00000589711.1 synaptogyrin 2 466 3 1 1 1 1 hsa-miR-4498 -0.28 -0.86 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TPSB2 ENST00000430512.2 tryptase beta 2 (gene/pseudogene) 5 1 0 1 0 0 hsa-miR-4498 -0.28 -0.28 N/A

ZBED1 ENST00000381223.4 zinc finger, BED-type containing 1 5 2 0 0 2 1 hsa-miR-5001-5p -0.28 -0.28 N/A

DYDC2 ENST00000372199.1 DPY30 domain containing 2 5 1 0 1 0 0 hsa-miR-5001-5p -0.28 -0.28 N/A

SLC39A4 ENST00000276833.5 solute carrier family 39 (zinc transporter), member 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

PCSK2 ENST00000377899.1 proprotein convertase subtilisin/kexin type 2 9 2 0 1 1 0 hsa-miR-5001-5p -0.28 -0.28 N/A

ACTN4 ENST00000252699.2 actinin, alpha 4 5688 2 0 2 0 2 hsa-miR-4498 -0.28 -0.28 N/A

KIAA1217 ENST00000396445.1 KIAA1217 320 1 0 1 0 1 hsa-miR-4498 -0.27 -0.28 N/A

NOTCH3 ENST00000263388.2 notch 3 45 2 0 1 1 1 hsa-miR-5001-5p -0.27 -0.34 N/A

HS6ST1 ENST00000259241.6 heparan sulfate 6-O-sulfotransferase 1 22 4 0 2 2 2 hsa-miR-5001-5p -0.27 -0.27 N/A

TMEM249 ENST00000398633.3 transmembrane protein 249 8 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

HOXB7 ENST00000239165.7 homeobox B7 6 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

CYCS ENST00000305786.2 cytochrome c, somatic 320 1 0 0 1 2 hsa-miR-5001-5p -0.27 -0.3 N/A

CARD14 ENST00000573882.1 caspase recruitment domain family, member 14 5 2 0 1 1 0 hsa-miR-4498 -0.27 -0.27 N/A

EPX ENST00000225371.5 eosinophil peroxidase 5 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

MAP3K9 ENST00000554752.2 mitogen-activated protein kinase kinase kinase 9 44 2 0 2 0 4 hsa-miR-5001-5p -0.27 -0.28 N/A

SPATA33 ENST00000301031.4 spermatogenesis associated 33 185 1 0 1 0 4 hsa-miR-4498 -0.27 -0.3 N/A

FAM65C ENST00000327979.2 family with sequence similarity 65, member C 17 2 0 1 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

BEST1 ENST00000449131.2 bestrophin 1 83 1 0 0 1 2 hsa-miR-4498 -0.27 -0.37 N/A

EDA ENST00000374553.2 ectodysplasin A 9 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

KLHL22 ENST00000328879.4 kelch-like family member 22 76 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

FAM153A ENST00000440605.3 family with sequence similarity 153, member A 5 2 0 1 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

VPS53 ENST00000437048.2 vacuolar protein sorting 53 homolog (S. cerevisiae) 1332 3 1 1 1 1 hsa-miR-4498 -0.27 -0.54 N/A integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 ITGA3 ENST00000007722.7 197 2 0 2 0 1 hsa-miR-4498 -0.27 -0.3 N/A receptor) ARHGAP23 ENST00000431231.2 Rho GTPase activating protein 23 289 2 0 1 1 0 hsa-miR-5001-5p -0.27 -0.29 N/A

MCTP2 ENST00000357742.4 multiple C2 domains, transmembrane 2 59 2 0 1 1 0 hsa-miR-5001-5p -0.27 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CDA ENST00000375071.3 cytidine deaminase 302 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A Uncharacterized protein; cDNA FLJ45964 fis, clone AC079612.1 ENST00000358775.1 5 2 0 2 0 1 hsa-miR-4498 -0.27 -0.27 N/A PLACE7014396 family with sequence similarity 19 (chemokine (C-C motif)- FAM19A4 ENST00000295569.7 5 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A like), member A4 ZBTB7A ENST00000322357.4 zinc finger and BTB domain containing 7A 37 1 1 0 0 2 hsa-miR-5001-5p -0.27 -0.27 N/A

AL354898.1 ENST00000277491.7 5 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

MSC ENST00000325509.4 musculin 27 2 0 1 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

IL17REL ENST00000389983.2 interleukin 17 receptor E-like 5 1 0 1 0 2 hsa-miR-4498 -0.27 -0.27 N/A

SDC1 ENST00000254351.4 syndecan 1 3152 2 1 1 0 0 hsa-miR-4498 -0.27 -0.3 N/A

ZNF609 ENST00000326648.3 zinc finger protein 609 103 6 1 2 3 2 hsa-miR-5001-5p -0.27 -0.29 N/A

MBLAC1 ENST00000398075.2 metallo-beta-lactamase domain containing 1 13 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

P4HA3 ENST00000331597.4 prolyl 4-hydroxylase, alpha polypeptide III 5 1 0 0 1 0 hsa-miR-5001-5p -0.27 -0.27 N/A

DOK1 ENST00000340004.6 docking protein 1, 62kDa (downstream of tyrosine kinase 1) 331 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

HOXD1 ENST00000331462.4 homeobox D1 35 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

GRAMD2 ENST00000309731.7 GRAM domain containing 2 5 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

LHX6 ENST00000373755.2 LIM homeobox 6 196 2 0 2 0 0 hsa-miR-4498 -0.27 -0.27 N/A

MEGF9 ENST00000373930.3 multiple EGF-like-domains 9 689 2 0 0 2 2 hsa-miR-5001-5p -0.27 -0.53 N/A

KIF23 ENST00000559279.1 kinesin family member 23 140 1 0 1 0 0 hsa-miR-4498 -0.27 -0.3 N/A guanine nucleotide binding protein (G protein), alpha GNAL ENST00000334049.6 99 3 1 1 1 0 hsa-miR-5001-5p -0.27 -0.37 N/A activating activity polypeptide, olfactory type GATAD2A ENST00000360315.3 GATA zinc finger domain containing 2A 986 4 1 2 1 5 hsa-miR-4498 -0.27 -0.36 N/A

IL21R ENST00000395755.1 interleukin 21 receptor 5 2 0 1 1 2 hsa-miR-5001-5p -0.27 -0.33 N/A

LRRC32 ENST00000260061.5 leucine rich repeat containing 32 10 4 1 1 2 1 hsa-miR-5001-5p -0.27 -0.27 N/A erythrocyte membrane protein band 4.1 (elliptocytosis 1, EPB41 ENST00000373798.1 53 3 0 3 0 1 hsa-miR-4498 -0.27 -0.27 N/A RH-linked) ZBTB4 ENST00000380599.4 zinc finger and BTB domain containing 4 1039 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

EVL ENST00000402714.2 Enah/Vasp-like 291 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

MAPK8IP1 ENST00000241014.2 mitogen-activated protein kinase 8 interacting protein 1 80 2 0 2 0 0 hsa-miR-4498 -0.27 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MYBL2 ENST00000217026.4 v-myb avian myeloblastosis viral oncogene homolog-like 2 71 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

RNF145 ENST00000274542.2 ring finger protein 145 12145 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

FAM221B ENST00000423537.2 family with sequence similarity 221, member B 5 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

ADAMTSL2 ENST00000354484.4 ADAMTS-like 2 5 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

GHRHR ENST00000409316.1 growth hormone releasing hormone receptor 5 1 0 1 0 1 hsa-miR-5001-5p -0.27 -0.27 N/A

HID1 ENST00000425042.2 HID1 domain containing 5 2 0 2 0 0 hsa-miR-4498 -0.27 -0.27 N/A

STC2 ENST00000265087.4 stanniocalcin 2 1112 2 1 1 0 0 hsa-miR-4498 -0.27 -0.32 N/A

FAM83F ENST00000333407.6 family with sequence similarity 83, member F 5 2 0 0 2 2 hsa-miR-5001-5p -0.27 -0.27 N/A Uncharacterized protein; cDNA FLJ43200 fis, clone AL009178.1 ENST00000597278.1 5 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A FEBRA2007793 COG4 ENST00000323786.5 component of oligomeric golgi complex 4 2411 2 0 0 2 0 hsa-miR-5001-5p -0.27 -0.27 N/A

MOB3C ENST00000319928.3 MOB kinase activator 3C 141 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

CNR1 ENST00000362094.5 cannabinoid receptor 1 (brain) 40 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.38 N/A

SYTL4 ENST00000372989.1 synaptotagmin-like 4 84 2 0 1 1 0 hsa-miR-4498 -0.27 -0.27 N/A

AK2 ENST00000467905.1 adenylate kinase 2 3125 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

RPP25 ENST00000322177.5 ribonuclease P/MRP 25kDa subunit 546 1 0 1 0 1 hsa-miR-4498 -0.27 -0.29 N/A

NAPB ENST00000377026.4 N-ethylmaleimide-sensitive factor attachment protein, beta 82 2 0 1 1 0 hsa-miR-4498 -0.27 -0.46 N/A Uncharacterized protein; cDNA FLJ36608 fis, clone AL590822.2 ENST00000597060.1 10 2 0 2 0 0 hsa-miR-4498 -0.27 -0.27 N/A TRACH2015824 ARMC5 ENST00000457010.2 armadillo repeat containing 5 376 3 0 2 1 0 hsa-miR-5001-5p -0.27 -0.27 N/A

LPO ENST00000262290.4 lactoperoxidase 5 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

IL27 ENST00000356897.1 interleukin 27 5 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A

FAM178B ENST00000417561.3 family with sequence similarity 178, member B 5 1 0 0 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

RP1L1 ENST00000382483.3 retinitis pigmentosa 1-like 1 5 1 0 0 1 1 hsa-miR-4498 -0.27 -0.27 N/A

CACNG4 ENST00000262138.3 calcium channel, voltage-dependent, gamma subunit 4 5 2 0 1 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

IDO2 ENST00000502986.2 indoleamine 2,3-dioxygenase 2 5 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

CD3E ENST00000361763.4 CD3e molecule, epsilon (CD3-TCR complex) 5 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SIGMAR1 ENST00000378892.1 sigma non-opioid intracellular receptor 1 591 1 0 0 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

CCL22 ENST00000219235.4 chemokine (C-C motif) ligand 22 5 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

FBXO10 ENST00000432825.2 F-box protein 10 14 1 0 0 1 0 hsa-miR-5001-5p -0.27 -0.27 N/A

RABEP2 ENST00000357573.6 rabaptin, RAB GTPase binding effector protein 2 5 2 0 2 0 0 hsa-miR-4498 -0.27 -0.27 N/A

CD151 ENST00000322008.4 CD151 molecule (Raph blood group) 13919 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A

MFGE8 ENST00000539437.1 milk fat globule-EGF factor 8 protein 404 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A

THSD4 ENST00000355327.3 thrombospondin, type I, domain containing 4 69 1 0 0 1 1 hsa-miR-5001-5p -0.27 -0.27 N/A

AP2M1 ENST00000382456.3 adaptor-related protein complex 2, mu 1 subunit 10753 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A X-ray repair complementing defective repair in Chinese XRCC2 ENST00000359321.1 140 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A hamster cells 2 BCL9L ENST00000334801.3 B-cell CLL/lymphoma 9-like 91 5 2 1 2 3 hsa-miR-4498 -0.27 -1.43 N/A

SPRY4 ENST00000344120.4 sprouty homolog 4 (Drosophila) 110 1 0 1 0 1 hsa-miR-4498 -0.27 -0.28 N/A

AC127496.1 ENST00000321930.4 Uncharacterized protein 27 1 0 1 0 1 hsa-miR-4498 -0.27 -0.34 N/A

VANGL1 ENST00000355485.2 VANGL planar cell polarity protein 1 721 2 0 1 1 3 hsa-miR-4498 -0.27 -0.27 N/A

PDCD1 ENST00000334409.5 programmed cell death 1 5 1 0 1 0 1 hsa-miR-5001-5p -0.27 -0.27 N/A

SFXN2 ENST00000369893.5 sideroflexin 2 547 2 0 1 1 0 hsa-miR-5001-5p -0.27 -0.27 N/A

CCHCR1 ENST00000396268.3 coiled-coil alpha-helical rod protein 1 9 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A solute carrier family 4, sodium borate transporter, member SLC4A11 ENST00000380056.3 159 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A 11 PDAP1 ENST00000350498.3 PDGFA associated protein 1 208 1 0 0 1 3 hsa-miR-5001-5p -0.27 -0.27 N/A

AMN ENST00000299155.5 amnion associated transmembrane protein 71 4 0 2 2 0 hsa-miR-4498 -0.27 -0.34 N/A

VEGFA ENST00000417285.2 vascular endothelial growth factor A 907 2 0 1 1 0 hsa-miR-4498 -0.27 -0.27 N/A

PHF11 ENST00000378319.3 PHD finger protein 11 95 1 0 0 1 0 hsa-miR-5001-5p -0.27 -0.29 N/A non-specific cytotoxic cell receptor protein 1 homolog NCCRP1 ENST00000339852.4 5 1 1 0 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A (zebrafish) solute carrier family 25 (mitochondrial SLC25A29 ENST00000392908.3 1101 1 0 1 0 1 hsa-miR-4498 -0.27 -0.27 N/A carnitine/acylcarnitine carrier), member 29 CAV3 ENST00000343849.2 caveolin 3 5 1 0 1 0 0 hsa-miR-5001-5p -0.27 -0.27 N/A v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene SRC ENST00000373578.2 170 2 0 0 2 0 hsa-miR-5001-5p -0.27 -0.27 N/A homolog Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FAM127A ENST00000257013.7 family with sequence similarity 127, member A 4717 1 0 1 0 0 hsa-miR-4498 -0.27 -0.27 N/A ras-related C3 botulinum toxin substrate 2 (rho family, small RAC2 ENST00000249071.6 38 1 0 1 0 0 hsa-miR-4498 -0.26 -0.27 N/A GTP binding protein Rac2) KDM4B ENST00000159111.4 lysine (K)-specific demethylase 4B 547 1 0 0 1 3 hsa-miR-5001-5p -0.26 -0.27 N/A

PPM1L ENST00000498165.1 protein phosphatase, Mg2+/Mn2+ dependent, 1L 59 3 0 1 2 0 hsa-miR-4498 -0.26 -0.43 N/A

C21orf2 ENST00000339818.4 chromosome 21 open reading frame 2 205 2 0 2 0 1 hsa-miR-4498 -0.26 -0.47 N/A

PPP1R11 ENST00000376773.1 protein phosphatase 1, regulatory (inhibitor) subunit 11 17 3 0 2 1 0 hsa-miR-5001-5p -0.26 -0.82 N/A

STAB2 ENST00000388887.2 stabilin 2 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

ITIH6 ENST00000218436.6 inter-alpha-trypsin inhibitor heavy chain family, member 6 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

SBF2 ENST00000256190.8 SET binding factor 2 65 1 1 0 0 1 hsa-miR-5001-5p -0.26 -0.26 N/A

LIN52 ENST00000555028.1 lin-52 homolog (C. elegans) 116 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

TMX4 ENST00000246024.2 thioredoxin-related transmembrane protein 4 466 1 0 1 0 1 hsa-miR-5001-5p -0.26 -0.3 N/A

ZKSCAN3 ENST00000377255.3 zinc finger with KRAB and SCAN domains 3 63 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.27 N/A

USP7 ENST00000344836.4 ubiquitin specific peptidase 7 (herpes virus-associated) 656 2 0 2 0 1 hsa-miR-4498 -0.26 -0.33 N/A

COL23A1 ENST00000390654.3 collagen, type XXIII, alpha 1 15 2 0 2 0 1 hsa-miR-4498 -0.26 -0.5 N/A

MIER2 ENST00000264819.4 mesoderm induction early response 1, family member 2 137 2 0 2 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

ZNF776 ENST00000317178.5 zinc finger protein 776 1447 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

CD8A ENST00000456996.2 CD8a molecule 34 1 0 1 0 1 hsa-miR-4498 -0.26 -0.26 N/A

FAM155B ENST00000252338.4 family with sequence similarity 155, member B 21 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

GLB1L2 ENST00000339772.7 galactosidase, beta 1-like 2 38 1 1 0 0 3 hsa-miR-5001-5p -0.26 -0.26 N/A

PATE4 ENST00000457514.2 prostate and testis expressed 4 5 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

AFAP1 ENST00000360265.4 actin filament associated protein 1 1966 2 0 2 0 0 hsa-miR-5001-5p -0.26 -0.27 N/A

TAL2 ENST00000334077.3 T-cell acute lymphocytic leukemia 2 21 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.35 N/A

PTBP1 ENST00000350092.4 polypyrimidine tract binding protein 1 7007 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A solute carrier family 43 (amino acid system L transporter), SLC43A2 ENST00000301335.5 68 3 0 2 1 1 hsa-miR-4498 -0.26 -0.42 N/A member 2 CIITA ENST00000324288.8 class II, major histocompatibility complex, transactivator 5 4 1 3 0 2 hsa-miR-4498 -0.26 -0.26 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TBC1D25 ENST00000376771.4 TBC1 domain family, member 25 24 1 0 1 0 2 hsa-miR-4498 -0.26 -0.26 N/A

FAM203B ENST00000377406.4 family with sequence similarity 203, member B 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

SYCN ENST00000318438.6 syncollin 5 1 0 0 1 0 hsa-miR-762 -0.26 -0.26 N/A

NHEJ1 ENST00000356853.5 nonhomologous end-joining factor 1 33 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

PLXNA2 ENST00000367033.3 plexin A2 8 2 0 1 1 1 hsa-miR-5001-5p -0.26 -0.26 N/A

AAGAB ENST00000261880.5 alpha- and gamma-adaptin binding protein 2536 2 1 0 1 2 hsa-miR-5001-5p -0.26 -0.53 N/A

LRRC8A ENST00000372600.4 leucine rich repeat containing 8 family, member A 71 2 0 0 2 1 hsa-miR-5001-5p -0.26 -0.26 N/A

GJB3 ENST00000373362.3 gap junction protein, beta 3, 31kDa 18 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

RHBG ENST00000368249.1 Rh family, B glycoprotein (gene/pseudogene) 23 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

PTCHD2 ENST00000304391.6 patched domain containing 2 7 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

AC093802.1 ENST00000407524.1 Uncharacterized protein 5 1 0 1 0 1 hsa-miR-5001-5p -0.26 -0.26 N/A hyperpolarization activated cyclic nucleotide-gated HCN4 ENST00000261917.3 19 3 1 2 0 2 hsa-miR-4498 -0.26 -0.28 N/A potassium channel 4 SNX24 ENST00000513881.1 sorting nexin 24 352 2 0 0 2 2 hsa-miR-5001-5p -0.26 -0.37 N/A

TYRO3 ENST00000263798.3 TYRO3 protein tyrosine kinase 70 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

UMODL1 ENST00000400424.2 uromodulin-like 1 5 2 0 1 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

SNAI1 ENST00000244050.2 snail family zinc finger 1 486 1 0 1 0 2 hsa-miR-4498 -0.26 -0.26 N/A

RSPO4 ENST00000217260.4 R-spondin 4 5 2 1 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

HABP2 ENST00000542051.1 hyaluronan binding protein 2 34 1 0 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

AHNAK ENST00000378024.4 AHNAK nucleoprotein 682 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

SIK1 ENST00000270162.6 salt-inducible kinase 1 2163 2 1 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

B3GAT1 ENST00000392580.1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 77 2 0 1 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

SCN4B ENST00000324727.4 sodium channel, voltage-gated, type IV, beta subunit 13 2 0 2 0 3 hsa-miR-4498 -0.26 -0.26 N/A

FOXS1 ENST00000375978.3 forkhead box S1 9 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

TMOD2 ENST00000249700.4 tropomodulin 2 (neuronal) 117 3 1 2 0 2 hsa-miR-5001-5p -0.26 -0.31 N/A

ZNF662 ENST00000541208.1 zinc finger protein 662 11 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score E2F1 ENST00000343380.5 E2F transcription factor 1 479 2 1 1 0 1 hsa-miR-4498 -0.26 -0.5 N/A

HDHD1 ENST00000381077.5 haloacid dehalogenase-like hydrolase domain containing 1 32 1 1 0 0 1 hsa-miR-5001-5p -0.26 -0.26 N/A

PCSK9 ENST00000302118.5 proprotein convertase subtilisin/kexin type 9 2345 2 0 1 1 2 hsa-miR-4498 -0.26 -0.27 N/A potassium voltage-gated channel, Shaw-related subfamily, KCNC3 ENST00000376959.2 5 3 1 1 1 1 hsa-miR-5001-5p -0.26 -0.26 N/A member 3 RAB4B ENST00000357052.2 RAB4B, member RAS oncogene family 52 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

TMEM121 ENST00000392519.2 transmembrane protein 121 7 1 0 1 0 1 hsa-miR-5001-5p -0.26 -0.26 N/A

GPR146 ENST00000297468.3 G protein-coupled receptor 146 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

SLAIN2 ENST00000264313.6 SLAIN motif family, member 2 859 2 0 1 1 0 hsa-miR-4498 -0.26 -0.33 N/A

TTYH2 ENST00000269346.4 tweety family member 2 16 2 0 0 2 0 hsa-miR-5001-5p -0.26 -0.31 N/A

DGKE ENST00000284061.3 diacylglycerol kinase, epsilon 64kDa 470 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.29 N/A

ZMIZ1 ENST00000334512.5 zinc finger, MIZ-type containing 1 568 5 1 2 2 2 hsa-miR-5001-5p -0.26 -0.26 N/A

GIMAP1 ENST00000307194.5 GTPase, IMAP family member 1 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

KMO ENST00000366559.4 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 5 1 1 0 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

KCNK3 ENST00000302909.3 potassium channel, subfamily K, member 3 19 2 0 2 0 3 hsa-miR-4498 -0.26 -0.4 N/A

PDDC1 ENST00000319863.8 Parkinson disease 7 domain containing 1 529 1 0 0 1 2 hsa-miR-5001-5p -0.26 -0.28 N/A

SLC38A7 ENST00000570101.1 solute carrier family 38, member 7 635 2 0 2 0 1 hsa-miR-4498 -0.26 -0.26 N/A

CECR2 ENST00000400573.5 cat eye syndrome chromosome region, candidate 2 46 1 0 1 0 2 hsa-miR-4498 -0.26 -0.34 N/A

VAV2 ENST00000406606.3 vav 2 guanine nucleotide exchange factor 477 2 0 2 0 2 hsa-miR-4498 -0.26 -0.26 N/A

CABP5 ENST00000293255.2 calcium binding protein 5 5 1 0 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

MPO ENST00000225275.3 myeloperoxidase 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

NT5M ENST00000389022.4 5',3'-nucleotidase, mitochondrial 534 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

GPC1 ENST00000264039.2 glypican 1 1687 2 0 2 0 2 hsa-miR-5001-5p -0.26 -0.26 N/A

LANCL2 ENST00000254770.2 LanC lantibiotic synthetase component C-like 2 (bacterial) 237 3 0 1 2 1 hsa-miR-5001-5p -0.26 -0.31 N/A

DUSP7 ENST00000495880.1 dual specificity phosphatase 7 68 3 0 2 1 1 hsa-miR-5001-5p -0.26 -0.3 N/A

CCDC81 ENST00000528728.1 coiled-coil domain containing 81 107 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ETF1 ENST00000499810.2 eukaryotic translation termination factor 1 31 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

MAD1L1 ENST00000402746.1 MAD1 mitotic arrest deficient-like 1 (yeast) 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A Uncharacterized protein; cDNA FLJ26048 fis, clone AC115618.1 ENST00000376775.2 5 1 0 1 0 1 hsa-miR-5001-5p -0.26 -0.26 N/A PRS02384 TMEM213 ENST00000442682.2 transmembrane protein 213 5 1 0 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

RNF181 ENST00000441634.1 ring finger protein 181 329 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A solute carrier family 37 (glucose-6-phosphate transporter), SLC37A2 ENST00000298280.5 18 2 1 0 1 3 hsa-miR-4498 -0.26 -0.32 N/A member 2 CCDC61 ENST00000263284.2 coiled-coil domain containing 61 174 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

SEC16B ENST00000308284.6 SEC16 homolog B (S. cerevisiae) 251 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

FAM203A ENST00000347708.4 family with sequence similarity 203, member A 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

CYP2S1 ENST00000310054.4 cytochrome P450, family 2, subfamily S, polypeptide 1 150 1 0 0 1 2 hsa-miR-5001-5p -0.26 -0.26 N/A

DKFZP779L1853 ENST00000595310.1 5 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

FCAMR ENST00000400962.3 Fc receptor, IgA, IgM, high affinity 5 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

AIM1L ENST00000527815.1 absent in melanoma 1-like 183 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A transducin-like enhancer of split 1 (E(sp1) homolog, TLE1 ENST00000376499.3 1996 1 0 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A Drosophila) TSPAN7 ENST00000378482.2 tetraspanin 7 2536 2 0 1 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

GATA4 ENST00000335135.4 GATA binding protein 4 5 2 0 1 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

ABTB1 ENST00000393363.3 ankyrin repeat and BTB (POZ) domain containing 1 180 1 0 1 0 0 hsa-miR-4498 -0.26 -0.26 N/A

LYPD5 ENST00000377950.3 LY6/PLAUR domain containing 5 9 1 0 1 0 1 hsa-miR-4498 -0.26 -0.26 N/A

PHPT1 ENST00000545326.1 phosphohistidine phosphatase 1 7440 1 0 1 0 0 hsa-miR-5001-5p -0.26 -0.26 N/A

MYLK2 ENST00000375994.2 myosin light chain kinase 2 16 2 1 0 1 0 hsa-miR-5001-5p -0.26 -0.26 N/A

SLC35F6 ENST00000344420.5 solute carrier family 35, member F6 272 4 2 1 1 2 hsa-miR-4498 -0.25 -0.81 N/A solute carrier family 9, subfamily B (NHA2, cation proton SLC9B2 ENST00000503103.1 22 1 0 1 0 0 hsa-miR-4498 -0.25 -0.34 N/A antiporter 2), member 2 OTOP2 ENST00000580223.1 otopetrin 2 5 1 0 0 1 0 hsa-miR-4498 -0.25 -0.25 N/A

C20orf24 ENST00000373852.5 chromosome 20 open reading frame 24 6086 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

EFCAB4A ENST00000450448.1 EF-hand calcium binding domain 4A 51 1 0 1 0 1 hsa-miR-4498 -0.25 -0.25 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF526 ENST00000301215.3 zinc finger protein 526 256 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

HNRNPA0 ENST00000314940.4 heterogeneous nuclear ribonucleoprotein A0 22668 1 0 0 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A

C15orf27 ENST00000388942.3 chromosome 15 open reading frame 27 17 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

EXOSC5 ENST00000221233.4 exosome component 5 1152 1 0 0 1 1 hsa-miR-5001-5p -0.25 -0.25 N/A

CCDC130 ENST00000586600.1 coiled-coil domain containing 130 382 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

RP11-247C2.2 ENST00000563727.1 HCG2004779; Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

ZNF70 ENST00000341976.3 zinc finger protein 70 99 2 0 1 1 3 hsa-miR-4498 -0.25 -0.51 N/A

FAM107A ENST00000464064.1 family with sequence similarity 107, member A 12 1 0 1 0 3 hsa-miR-4498 -0.25 -0.27 N/A

CHAD ENST00000258969.4 chondroadherin 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

ANGPT4 ENST00000381922.3 angiopoietin 4 5 2 0 2 0 2 hsa-miR-5001-5p -0.25 -0.3 N/A

UPK3B ENST00000443097.2 uroplakin 3B 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

TNFRSF8 ENST00000263932.2 tumor necrosis factor receptor superfamily, member 8 5 1 0 0 1 1 hsa-miR-4498 -0.25 -0.25 N/A

IL18 ENST00000280357.7 interleukin 18 (interferon-gamma-inducing factor) 5 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

IRF7 ENST00000525445.1 interferon regulatory factor 7 10 1 0 0 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A

RP11-644F5.10 ENST00000550412.1 Uncharacterized protein 265 2 0 0 2 0 hsa-miR-5001-5p -0.25 -0.27 N/A

HIP1 ENST00000336926.6 huntingtin interacting protein 1 37 3 1 0 2 1 hsa-miR-5001-5p -0.25 -0.34 N/A

ARHGEF18 ENST00000319670.9 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2596 3 0 2 1 3 hsa-miR-4498 -0.25 -0.25 N/A

HOXD11 ENST00000249504.5 homeobox D11 124 2 0 1 1 0 hsa-miR-5001-5p -0.25 -0.31 N/A

RHOQ ENST00000238738.4 ras homolog family member Q 179 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

ICAM2 ENST00000578379.1 intercellular adhesion molecule 2 16 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

C11orf45 ENST00000310799.3 chromosome 11 open reading frame 45 14 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

PFKFB2 ENST00000367080.3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 83 2 1 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

KLHL25 ENST00000337975.5 kelch-like family member 25 98 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

ZFP90 ENST00000398253.2 ZFP90 zinc finger protein 174 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

MPRIP ENST00000341712.4 myosin phosphatase Rho interacting protein 521 4 1 2 1 2 hsa-miR-4498 -0.25 -0.3 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score WIZ ENST00000389282.4 widely interspaced zinc finger motifs 1321 3 0 2 1 0 hsa-miR-4498 -0.25 -0.29 N/A

PLAUR ENST00000601723.1 plasminogen activator, urokinase receptor 6259 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

ZDHHC12 ENST00000372663.4 zinc finger, DHHC-type containing 12 56 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

GJC2 ENST00000366714.2 gap junction protein, gamma 2, 47kDa 10 1 0 1 0 1 hsa-miR-4498 -0.25 -0.25 N/A

KLK14 ENST00000391802.1 kallikrein-related peptidase 14 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

ANKRD22 ENST00000371930.4 ankyrin repeat domain 22 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

C9orf38 ENST00000355513.4 chromosome 9 open reading frame 38 5 1 0 0 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A

STS ENST00000217961.4 steroid sulfatase (microsomal), isozyme S 64 2* 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

C1orf109 ENST00000358011.4 chromosome 1 open reading frame 109 6 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

CHD3 ENST00000380358.4 chromodomain helicase DNA binding protein 3 700 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

MTMR1 ENST00000445323.2 myotubularin related protein 1 489 3 0 2 1 1 hsa-miR-4498 -0.25 -0.25 N/A

FOXC2 ENST00000320354.4 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 665 2 0 1 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A nuclear casein kinase and cyclin-dependent kinase substrate NUCKS1 ENST00000367142.4 1692 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A 1 AKT2 ENST00000392038.2 v-akt murine thymoma viral oncogene homolog 2 525 3 1 2 0 2 hsa-miR-4498 -0.25 -0.6 N/A

KRT9 ENST00000246662.4 keratin 9 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

TBC1D2B ENST00000409931.3 TBC1 domain family, member 2B 5 3 0 2 1 0 hsa-miR-4498 -0.25 -0.25 N/A

PALD1 ENST00000263563.6 phosphatase domain containing, paladin 1 108 1 0 0 1 1 hsa-miR-5001-5p -0.25 -0.25 N/A

TGIF2-C20orf24 ENST00000558530.1 TGIF2-C20orf24 readthrough 6086 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

FBXO4 ENST00000509134.1 F-box protein 4 230 1 0 0 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A

ATP6AP1 ENST00000369762.2 ATPase, H+ transporting, lysosomal accessory protein 1 2095 1 0 0 1 1 hsa-miR-5001-5p -0.25 -0.25 N/A

TBC1D3H ENST00000394359.3 TBC1 domain family, member 3H 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

CNN1 ENST00000252456.2 calponin 1, basic, smooth muscle 96 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

FAM216B ENST00000537894.1 family with sequence similarity 216, member B 5 1 0 1 0 1 hsa-miR-4498 -0.25 -0.26 N/A

MARVELD3 ENST00000268485.3 MARVEL domain containing 3 55 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

AQP5 ENST00000293599.6 aquaporin 5 10 2 0 2 0 1 hsa-miR-4498 -0.25 -0.25 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MAP3K6 ENST00000374040.3 mitogen-activated protein kinase kinase kinase 6 25 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

TAX1BP3 ENST00000225525.3 Tax1 (human T-cell leukemia virus type I) binding protein 3 4402 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

LMF1 ENST00000262301.11 lipase maturation factor 1 155 11 4 6 1 5 hsa-miR-4498 -0.25 -1.23 N/A

WDFY1 ENST00000233055.4 WD repeat and FYVE domain containing 1 88 2 0 0 2 0 hsa-miR-4498 -0.25 -0.27 N/A

HSPA12A ENST00000369209.3 heat shock 70kDa protein 12A 37 3* 0 1 1 2 hsa-miR-5001-5p -0.25 -0.3 N/A

IARS ENST00000375629.3 isoleucyl-tRNA synthetase 65 1 0 0 1 1 hsa-miR-5001-5p -0.25 -0.25 N/A

CRTAP ENST00000320954.6 cartilage associated protein 3154 2 0 1 1 2 hsa-miR-5001-5p -0.25 -0.6 N/A

EGLN1 ENST00000366641.3 egl-9 family hypoxia-inducible factor 1 505 1 1 0 0 0 hsa-miR-4498 -0.25 -0.25 N/A spermatogenesis and oogenesis specific basic helix-loop- SOHLH1 ENST00000298466.5 5 1 0 1 0 1 hsa-miR-4498 -0.25 -0.25 N/A helix 1 SYT9 ENST00000318881.6 synaptotagmin IX 5 2 0 0 2 1 hsa-miR-5001-5p -0.25 -0.25 N/A

RNF220 ENST00000372247.2 ring finger protein 220 474 1 0 1 0 1 hsa-miR-5001-5p -0.25 -0.25 N/A

FAHD2A ENST00000233379.4 fumarylacetoacetate hydrolase domain containing 2A 9 3 0 3 0 2 hsa-miR-4498 -0.25 -0.35 N/A

CTNS ENST00000046640.3 cystinosin, lysosomal cystine transporter 308 3 1 2 0 1 hsa-miR-4498 -0.25 -0.62 N/A

GRM4 ENST00000538487.2 glutamate receptor, metabotropic 4 5 3 0 2 1 2 hsa-miR-5001-5p -0.25 -0.5 N/A

GOSR2 ENST00000576910.2 golgi SNAP receptor complex member 2 1099 2 0 2 0 0 hsa-miR-4498 -0.25 -0.46 N/A

SPATA8 ENST00000328504.3 spermatogenesis associated 8 10 1 0 0 1 0 hsa-miR-5001-5p -0.25 -0.25 N/A

PTPRT ENST00000373187.1 protein tyrosine phosphatase, receptor type, T 5 2 2 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

DGKQ ENST00000273814.3 diacylglycerol kinase, theta 110kDa 184 1 0 0 1 4 hsa-miR-5001-5p -0.25 -0.25 N/A

CD207 ENST00000410009.3 CD207 molecule, langerin 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

LASP1 ENST00000318008.6 LIM and SH3 protein 1 552 1 1 0 0 2 hsa-miR-5001-5p -0.25 -0.26 N/A

PTER ENST00000378000.1 phosphotriesterase related 217 1 0 1 0 1 hsa-miR-4498 -0.25 -0.29 N/A

GRB10 ENST00000398812.2 growth factor receptor-bound protein 10 1382 1 0 1 0 1 hsa-miR-4498 -0.25 -0.29 N/A

WNT5A ENST00000474267.1 wingless-type MMTV integration site family, member 5A 2080 2 0 0 2 1 hsa-miR-5001-5p -0.25 -0.25 N/A

CDRT4 ENST00000312177.6 CMT1A duplicated region transcript 4 109 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

TMCC2 ENST00000358024.3 transmembrane and coiled-coil domain family 2 5 1 0 1 0 2 hsa-miR-4498 -0.25 -0.25 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM129 ENST00000303277.2 transmembrane protein 129 57 1 1 0 0 1 hsa-miR-5001-5p -0.25 -0.25 N/A

C20orf27 ENST00000217195.8 chromosome 20 open reading frame 27 2687 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

OLFML1 ENST00000329293.3 olfactomedin-like 1 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

C10orf53 ENST00000374112.3 chromosome 10 open reading frame 53 5 1 0 1 0 2 hsa-miR-4498 -0.25 -0.25 N/A

MRPS27 ENST00000261413.5 mitochondrial ribosomal protein S27 1137 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A proteasome (prosome, macropain) activator subunit 3 (PA28 PSME3 ENST00000541124.1 3605 1 0 1 0 2 hsa-miR-5001-5p -0.25 -0.33 N/A gamma; Ki) CNNM4 ENST00000540067.1 cyclin M4 1249 1 0 1 0 2 hsa-miR-4498 -0.25 -0.25 N/A Homo sapiens torsin A interacting protein 2 (TOR1AIP2), IFRG15 ENST00000553856.1 482 1 0 1 0 2 hsa-miR-5001-5p -0.25 -0.27 N/A transcript variant 1, mRNA. ARPC1A ENST00000262942.5 actin related protein 2/3 complex, subunit 1A, 41kDa 99 1 0 1 0 0 hsa-miR-5001-5p -0.25 -0.26 N/A

UCK2 ENST00000372212.4 uridine-cytidine kinase 2 437 2 0 1 1 0 hsa-miR-5001-5p -0.25 -0.27 N/A

RAB11FIP3 ENST00000262305.4 RAB11 family interacting protein 3 (class II) 71 2 0 2 0 1 hsa-miR-4498 -0.25 -0.26 N/A adaptor protein, phosphotyrosine interaction, PH domain and APPL2 ENST00000258530.3 434 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A leucine zipper containing 2 SLC39A13 ENST00000524928.1 solute carrier family 39 (zinc transporter), member 13 845 2 0 1 1 4 hsa-miR-5001-5p -0.25 -0.25 N/A

ZNF687 ENST00000368879.2 zinc finger protein 687 1250 1 0 1 0 1 hsa-miR-5001-5p -0.25 -0.25 N/A

CYB561A3 ENST00000294072.4 cytochrome b561 family, member A3 470 2 0 2 0 2 hsa-miR-4498 -0.25 -0.25 N/A

DDX11 ENST00000251758.5 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 175 3 0 0 3 2 hsa-miR-5001-5p -0.25 -0.25 N/A

MYD88 ENST00000495303.1 myeloid differentiation primary response 88 319 1 1 0 0 0 hsa-miR-5001-5p -0.25 -0.25 N/A

CASP5 ENST00000393139.2 caspase 5, apoptosis-related cysteine peptidase 5 1 0 1 0 0 hsa-miR-4498 -0.25 -0.25 N/A

GPI ENST00000415930.3 glucose-6-phosphate isomerase 8230 1 0 1 0 0 hsa-miR-4498 -0.25 -0.28 N/A

UST ENST00000367463.4 uronyl-2-sulfotransferase 933 2 0 1 1 0 hsa-miR-5001-5p -0.25 -0.26 N/A

SOX9 ENST00000245479.2 SRY (sex determining region Y)-box 9 2595 2 0 1 1 0 hsa-miR-4498 -0.25 -0.29 N/A

XYLT1 ENST00000261381.6 xylosyltransferase I 159 2 0 1 1 3 hsa-miR-5001-5p -0.24 -0.24 N/A family with sequence similarity 19 (chemokine (C-C motif)- FAM19A5 ENST00000358295.5 14 2 0 2 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A like), member A5 egf-like module containing, mucin-like, hormone receptor- EMR1 ENST00000250572.8 6 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A like 1 GJD3 ENST00000578689.1 gap junction protein, delta 3, 31.9kDa 0 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TOM1 ENST00000382034.5 target of myb1 (chicken) 309 2 0 1 1 1 hsa-miR-4498 -0.24 -0.24 N/A

POM121 ENST00000395270.1 POM121 transmembrane nucleoporin 5 1 1 0 0 1 hsa-miR-4498 -0.24 -0.24 N/A

EHD2 ENST00000263277.3 EH-domain containing 2 2072 2 0 2 0 3 hsa-miR-4498 -0.24 -0.24 N/A

ZNF410 ENST00000555044.1 zinc finger protein 410 718 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.26 N/A

UBA2 ENST00000246548.4 ubiquitin-like modifier activating enzyme 2 122 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.28 N/A

LRRC1 ENST00000370888.1 leucine rich repeat containing 1 343 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

ANKS1B ENST00000546960.1 ankyrin repeat and sterile alpha motif domain containing 1B 21 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

AC092850.1 ENST00000598023.1 Protein LOC100996701 5 1 0 0 1 2 hsa-miR-5001-5p -0.24 -0.24 N/A

SOX12 ENST00000342665.2 SRY (sex determining region Y)-box 12 6341 2 0 1 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

SMG5 ENST00000361813.5 SMG5 nonsense mediated mRNA decay factor 1093 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

DDX42 ENST00000578681.1 DEAD (Asp-Glu-Ala-Asp) box helicase 42 797 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

DECR2 ENST00000219481.5 2,4-dienoyl CoA reductase 2, peroxisomal 1049 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

VAMP5 ENST00000306384.4 vesicle-associated membrane protein 5 460 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5- CHRFAM7A ENST00000397827.3 5 1 0 0 1 1 hsa-miR-5001-5p -0.24 -0.24 N/A 10) and FAM7A (family with sequence similarity 7A, exons STX17 ENST00000259400.6 syntaxin 17 510 2 1 0 1 0 hsa-miR-5001-5p -0.24 -0.32 N/A

PPM1F ENST00000263212.5 protein phosphatase, Mg2+/Mn2+ dependent, 1F 786 2 1 1 0 4 hsa-miR-4498 -0.24 -0.34 N/A

CSRNP1 ENST00000273153.5 cysteine-serine-rich nuclear protein 1 544 2 0 1 1 1 hsa-miR-4498 -0.24 -0.3 N/A

RAB3D ENST00000222120.3 RAB3D, member RAS oncogene family 111 1 0 1 0 1 hsa-miR-4498 -0.24 -0.25 N/A

APOL6 ENST00000409652.4 apolipoprotein L, 6 5 2 1 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

BECN1 ENST00000438274.3 beclin 1, autophagy related 2879 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

C17orf62 ENST00000342572.8 chromosome 17 open reading frame 62 89 1 0 1 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

CSF3 ENST00000394149.3 colony stimulating factor 3 (granulocyte) 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

OTUD4 ENST00000454497.2 OTU domain containing 4 18 2 0 2 0 0 hsa-miR-4498 -0.24 -0.24 N/A

NKAIN2 ENST00000368417.1 Na+/K+ transporting ATPase interacting 2 34 2 0 0 2 1 hsa-miR-4498 -0.24 -0.24 N/A

CD177 ENST00000378009.4 CD177 molecule 5 1 0 0 1 2 hsa-miR-5001-5p -0.24 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score DPPA3 ENST00000345088.2 developmental pluripotency associated 3 11 2 1 1 0 1 hsa-miR-5001-5p -0.24 -0.5 N/A

FDX1L ENST00000541276.1 ferredoxin 1-like 198 2 0 1 1 1 hsa-miR-4498 -0.24 -0.39 N/A pregnancy up-regulated non-ubiquitously expressed CaM PNCK ENST00000340888.3 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A kinase ARF1 ENST00000540651.1 ADP-ribosylation factor 1 235 1 1 0 0 1 hsa-miR-4498 -0.24 -0.26 N/A

USP36 ENST00000542802.3 ubiquitin specific peptidase 36 192 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

FOXH1 ENST00000377317.4 forkhead box H1 8 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

HOXA1 ENST00000355633.5 homeobox A1 157 2 0 1 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

FAM46B ENST00000289166.5 family with sequence similarity 46, member B 18 3 0 0 3 0 hsa-miR-5001-5p -0.24 -0.24 N/A

TRAFD1 ENST00000257604.5 TRAF-type zinc finger domain containing 1 3418 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

ADAT3 ENST00000329478.2 adenosine deaminase, tRNA-specific 3 168 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

SHROOM4 ENST00000376020.2 shroom family member 4 5 1 0 1 0 3 hsa-miR-4498 -0.24 -0.24 N/A

AC008948.1 ENST00000597120.1 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

SNCB ENST00000310112.3 synuclein, beta 5 1 0 0 1 1 hsa-miR-5001-5p -0.24 -0.24 N/A

DHRS12 ENST00000218981.1 dehydrogenase/reductase (SDR family) member 12 17 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

CHI3L1 ENST00000255409.3 chitinase 3-like 1 (cartilage glycoprotein-39) 16 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

CYB561 ENST00000584031.1 cytochrome b561 10 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

SDHAF2 ENST00000543265.1 succinate dehydrogenase complex assembly factor 2 545 2 0 1 1 2 hsa-miR-4498 -0.24 -0.66 N/A

CANT1 ENST00000392446.5 calcium activated nucleotidase 1 538 2 0 1 1 0 hsa-miR-5001-5p -0.24 -0.26 N/A

KLHL8 ENST00000273963.5 kelch-like family member 8 266 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

CRISPLD1 ENST00000262207.4 cysteine-rich secretory protein LCCL domain containing 1 358 2 0 1 1 0 hsa-miR-5001-5p -0.24 -0.42 N/A

CDK19 ENST00000368911.3 cyclin-dependent kinase 19 51 1 1 0 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A

SERPINB9 ENST00000380698.4 serpin peptidase inhibitor, clade B (ovalbumin), member 9 154 2 0 2 0 1 hsa-miR-4498 -0.24 -0.38 N/A

IL17RE ENST00000454190.2 interleukin 17 receptor E 7 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

IL22RA2 ENST00000339602.3 interleukin 22 receptor, alpha 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

DCHS1 ENST00000299441.3 dachsous cadherin-related 1 54 1 0 1 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FKBP10 ENST00000321562.4 FK506 binding protein 10, 65 kDa 527 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

DNAJA3 ENST00000262375.6 DnaJ (Hsp40) homolog, subfamily A, member 3 3281 1 0 0 1 3 hsa-miR-5001-5p -0.24 -0.24 N/A

DCTN1 ENST00000361874.3 dynactin 1 1036 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

EDN2 ENST00000372587.4 endothelin 2 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

TTC31 ENST00000410003.1 tetratricopeptide repeat domain 31 132 1 0 1 0 2 hsa-miR-5001-5p -0.24 -0.24 N/A

UNC5CL ENST00000244565.3 unc-5 homolog C (C. elegans)-like 25 1 0 1 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A

CAPN5 ENST00000531028.1 calpain 5 89 3 1 1 1 1 hsa-miR-5001-5p -0.24 -0.74 N/A

ZNF260 ENST00000523638.1 zinc finger protein 260 165 1 0 1 0 0 hsa-miR-5001-5p -0.24 -0.25 N/A

GRAMD1B ENST00000529750.1 GRAM domain containing 1B 35 3 0 1 2 2 hsa-miR-5001-5p -0.24 -0.45 N/A

GSTO2 ENST00000369707.2 glutathione S-transferase omega 2 97 2 1 0 1 3 hsa-miR-5001-5p -0.24 -0.48 N/A

SRM ENST00000376957.2 spermidine synthase 46 2 0 1 1 3 hsa-miR-4498 -0.24 -0.36 N/A

BRD9 ENST00000323510.4 bromodomain containing 9 281 1 0 1 0 3 hsa-miR-5001-5p -0.24 -0.28 N/A mitochondrial rRNA methyltransferase 1 homolog (S. MRM1 ENST00000250156.7 84 1 1 0 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A cerevisiae) FKBP6 ENST00000413573.2 FK506 binding protein 6, 36kDa 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

SPRY3 ENST00000302805.2 sprouty homolog 3 (Drosophila) 5 2 1 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A CDNA FLJ26432 fis, clone KDN01418; Uncharacterized AP000974.1 ENST00000544076.1 5 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A protein NOS1AP ENST00000361897.5 nitric oxide synthase 1 (neuronal) adaptor protein 5 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

LRTM2 ENST00000543818.1 leucine-rich repeats and transmembrane domains 2 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

TSSC1 ENST00000398659.4 tumor suppressing subtransferable candidate 1 22 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

KIAA1755 ENST00000279024.4 KIAA1755 5 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

YKT6 ENST00000223369.2 YKT6 v-SNARE homolog (S. cerevisiae) 2409 2 1 0 1 3 hsa-miR-5001-5p -0.24 -0.24 N/A

RHBDD1 ENST00000341329.3 rhomboid domain containing 1 667 2 0 2 0 1 hsa-miR-4498 -0.24 -0.4 N/A X-prolyl aminopeptidase (aminopeptidase P) 2, membrane- XPNPEP2 ENST00000371106.3 5 2 0 2 0 0 hsa-miR-4498 -0.24 -0.34 N/A bound SRL ENST00000399609.3 sarcalumenin 5 2 0 2 0 0 hsa-miR-4498 -0.24 -0.24 N/A

UBL4A ENST00000369660.4 ubiquitin-like 4A 3118 1 0 1 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SCNN1A ENST00000360168.3 sodium channel, non-voltage-gated 1 alpha subunit 5 2 0 2 0 0 hsa-miR-4498 -0.24 -0.24 N/A

SH3GL3 ENST00000535412.1 SH3-domain GRB2-like 3 74 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

BRD2 ENST00000374825.4 bromodomain containing 2 695 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

PCDHB11 ENST00000354757.3 protocadherin beta 11 12 1 1 0 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

IGSF1 ENST00000370900.1 immunoglobulin superfamily, member 1 416 1 0 1 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

PRRT1 ENST00000211413.5 proline-rich transmembrane protein 1 19 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

GPR124 ENST00000315215.7 G protein-coupled receptor 124 72 2 0 2 0 0 hsa-miR-4498 -0.24 -0.24 N/A

PLCB3 ENST00000540288.1 phospholipase C, beta 3 (phosphatidylinositol-specific) 15 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

CHPF ENST00000243776.6 chondroitin polymerizing factor 4910 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

BTN2A2 ENST00000432533.2 butyrophilin, subfamily 2, member A2 125 1 0 1 0 1 hsa-miR-4498 -0.24 -0.25 N/A

SNX1 ENST00000353874.4 sorting nexin 1 1296 2 0 2 0 0 hsa-miR-4498 -0.24 -0.35 N/A

ACER3 ENST00000532485.1 alkaline ceramidase 3 295 2 0 0 2 0 hsa-miR-5001-5p -0.24 -0.28 N/A

CPD ENST00000225719.4 carboxypeptidase D 1766 1 1 0 0 1 hsa-miR-5001-5p -0.24 -0.24 N/A

HS3ST2 ENST00000261374.3 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 5 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

CMIP ENST00000537098.3 c-Maf inducing protein 2670 2 0 2 0 1 hsa-miR-4498 -0.24 -0.24 N/A

TNFRSF18 ENST00000379268.2 tumor necrosis factor receptor superfamily, member 18 5 1 0 1 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A

SACM1L ENST00000389061.5 SAC1 suppressor of actin mutations 1-like (yeast) 159 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

ARL4C ENST00000390645.2 ADP-ribosylation factor-like 4C 84 2 0 1 1 0 hsa-miR-5001-5p -0.24 -0.25 N/A

ASF1B ENST00000263382.3 anti-silencing function 1B histone chaperone 300 1 0 1 0 2 hsa-miR-4498 -0.24 -0.24 N/A

FAM189A1 ENST00000261275.4 family with sequence similarity 189, member A1 12 1 0 0 1 2 hsa-miR-5001-5p -0.24 -0.24 N/A

GJB4 ENST00000339480.1 gap junction protein, beta 4, 30.3kDa 5 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

CYTH4 ENST00000248901.6 cytohesin 4 5 1 0 1 0 2 hsa-miR-4498 -0.24 -0.24 N/A

UQCRC2 ENST00000268379.4 ubiquinol-cytochrome c reductase core protein II 170 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

ZBTB2 ENST00000325144.4 zinc finger and BTB domain containing 2 832 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A

LENG9 ENST00000333834.4 leukocyte receptor cluster (LRC) member 9 5 1 0 0 1 0 hsa-miR-4498 -0.24 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MOB3A ENST00000357066.3 MOB kinase activator 3A 13 1 0 1 0 2 hsa-miR-5001-5p -0.24 -0.24 N/A Putative inactive alpha-1,3-mannosyl-glycoprotein 4-beta-N- RP11-480I12.4 ENST00000330493.5 5 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A acetylglucosaminyltransferase-like protein LOC641515 translocase of outer mitochondrial membrane 40 homolog TOMM40L ENST00000367987.1 13 1 0 1 0 0 hsa-miR-4498 -0.24 -0.24 N/A (yeast)-like SFTPB ENST00000519937.2 surfactant protein B 5 3 0 1 2 0 hsa-miR-4498 -0.24 -0.24 N/A

PRRT2 ENST00000300797.6 proline-rich transmembrane protein 2 33 1 0 1 0 1 hsa-miR-4498 -0.24 -0.24 N/A

RSPH6A ENST00000597055.1 radial spoke head 6 homolog A (Chlamydomonas) 5 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

CCDC157 ENST00000405659.1 coiled-coil domain containing 157 173 1 0 0 1 0 hsa-miR-5001-5p -0.24 -0.24 N/A

JPH4 ENST00000356300.4 junctophilin 4 5 2 0 2 0 0 hsa-miR-4498 -0.24 -0.24 N/A

ZSCAN25 ENST00000394152.2 zinc finger and SCAN domain containing 25 230 2 0 0 2 0 hsa-miR-5001-5p -0.24 -0.33 N/A

STRN ENST00000263918.4 striatin, calmodulin binding protein 476 2 2 0 0 0 hsa-miR-5001-5p -0.24 -0.34 N/A

MAPKAPK2 ENST00000294981.4 mitogen-activated protein kinase-activated protein kinase 2 178 2 0 2 0 0 hsa-miR-5001-5p -0.24 -0.24 N/A pleckstrin homology domain containing, family M, member PLEKHM3 ENST00000427836.2 11 3 1 1 1 3 hsa-miR-5001-5p -0.24 -0.46 N/A 3 MOG ENST00000376902.3 myelin oligodendrocyte glycoprotein 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

ISL2 ENST00000290759.4 ISL LIM homeobox 2 381 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A ArfGAP with GTPase domain, ankyrin repeat and PH AGAP3 ENST00000463381.1 1871 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A domain 3 ZC3H18 ENST00000301011.5 zinc finger CCCH-type containing 18 15 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

CBX1 ENST00000393408.3 chromobox homolog 1 26 1 0 0 1 0 hsa-miR-4498 -0.23 -0.23 N/A

YDJC ENST00000398873.3 YdjC homolog (bacterial) 494 1 1 0 0 0 hsa-miR-5001-5p -0.23 -0.24 N/A dopamine beta-hydroxylase (dopamine beta- DBH ENST00000393056.2 5 2 0 2 0 1 hsa-miR-4498 -0.23 -0.23 N/A monooxygenase) PLK2 ENST00000274289.3 polo-like kinase 2 689 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

DAB2IP ENST00000408936.3 DAB2 interacting protein 1787 2 0 2 0 2 hsa-miR-4498 -0.23 -0.23 N/A small nuclear RNA activating complex, polypeptide 4, SNAPC4 ENST00000298532.2 875 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A 190kDa ADCY10 ENST00000545172.1 adenylate cyclase 10 (soluble) 5 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

PLD6 ENST00000321560.3 phospholipase D family, member 6 280 1 1 0 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

LBH ENST00000406087.1 limb bud and heart development 1956 1 0 1 0 0 hsa-miR-4498 -0.23 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score IGF2 ENST00000381395.1 insulin-like growth factor 2 (somatomedin A) 1371 1 0 1 0 3 hsa-miR-4498 -0.23 -0.31 N/A

GBP6 ENST00000370456.4 guanylate binding protein family, member 6 5 3 1 2 0 1 hsa-miR-4498 -0.23 -0.53 N/A

LDOC1 ENST00000370526.2 leucine zipper, down-regulated in cancer 1 14 1 0 0 1 1 hsa-miR-5001-5p -0.23 -0.25 N/A

UQCR11 ENST00000589880.1 ubiquinol-cytochrome c reductase, complex III subunit XI 34490 4 2 0 2 0 hsa-miR-5001-5p -0.23 -0.94 N/A

NCOA7 ENST00000392477.2 nuclear receptor coactivator 7 2967 1 1 0 0 1 hsa-miR-4498 -0.23 -0.23 N/A

PGP ENST00000333503.7 phosphoglycolate phosphatase 153 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

EFCC1 ENST00000436022.2 EF-hand and coiled-coil domain containing 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.23 -0.23 N/A

CRHR1 ENST00000398285.3 corticotropin releasing hormone receptor 1 9 1 1 0 0 2 hsa-miR-4498 -0.23 -0.23 N/A

ALPP ENST00000392027.2 alkaline phosphatase, placental 5 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

C2orf66 ENST00000342506.2 chromosome 2 open reading frame 66 22 1 0 1 0 0 hsa-miR-4498 -0.23 -0.31 N/A

ATG10 ENST00000282185.3 autophagy related 10 25 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.3 N/A

AC012360.2 ENST00000595531.1 LOC644617 protein; Uncharacterized protein 430 1 0 0 1 1 hsa-miR-5001-5p -0.23 -0.24 N/A

SAMD4B ENST00000314471.6 sterile alpha motif domain containing 4B 46 2 0 2 0 0 hsa-miR-4498 -0.23 -0.36 N/A

KLHDC8A ENST00000367155.3 kelch domain containing 8A 8 3 0 2 1 1 hsa-miR-4498 -0.23 -0.35 N/A

TSPAN10 ENST00000328585.4 tetraspanin 10 91 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

PABPC1L2B ENST00000373521.2 poly(A) binding protein, cytoplasmic 1-like 2B 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

FBXW4 ENST00000331272.7 F-box and WD repeat domain containing 4 5 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

DUOXA1 ENST00000558996.1 dual oxidase maturation factor 1 5 1 1 0 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A Homo sapiens leucine zipper, putative tumor suppressor LZTS3 ENST00000329152.3 78 2 0 1 1 3 hsa-miR-5001-5p -0.23 -0.23 N/A family member 3 (LZTS3), transcript variant 2, mRNA. CDH7 ENST00000397968.2 cadherin 7, type 2 42 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.27 N/A

SIRT2 ENST00000358931.5 sirtuin 2 25 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.27 N/A

NCK1 ENST00000469404.1 NCK adaptor protein 1 415 2 0 1 1 0 hsa-miR-4498 -0.23 -0.36 N/A

LYRM7 ENST00000507584.1 LYR motif containing 7 217 1 1 0 0 0 hsa-miR-5001-5p -0.23 -0.47 N/A

HSPA12B ENST00000254963.2 heat shock 70kD protein 12B 16 1 0 1 0 3 hsa-miR-4498 -0.23 -0.24 N/A

ACBD3 ENST00000366812.5 acyl-CoA binding domain containing 3 828 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MORF4L2 ENST00000360458.1 mortality factor 4 like 2 17 1 0 0 1 0 hsa-miR-4498 -0.23 -0.23 N/A

DNAL4 ENST00000216068.4 dynein, axonemal, light chain 4 9 1 0 1 0 2 hsa-miR-4498 -0.23 -0.23 N/A

RADIL ENST00000536091.1 Ras association and DIL domains 10 2 0 2 0 7 hsa-miR-4498 -0.23 -0.23 N/A

PABPC1L2A ENST00000373519.1 poly(A) binding protein, cytoplasmic 1-like 2A 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

PLA2G3 ENST00000215885.3 phospholipase A2, group III 5 1 0 1 0 1 hsa-miR-4498 -0.23 -0.23 N/A

P4HB ENST00000331483.4 prolyl 4-hydroxylase, beta polypeptide 17931 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

TFCP2L1 ENST00000263707.5 transcription factor CP2-like 1 36 4 0 3 1 1 hsa-miR-5001-5p -0.23 -0.37 N/A

R3HCC1 ENST00000265806.6 R3H domain and coiled-coil containing 1 112 1 0 1 0 1 hsa-miR-4498 -0.23 -0.34 N/A

C9orf47 ENST00000375851.2 chromosome 9 open reading frame 47 5 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

FDXR ENST00000455107.2 ferredoxin reductase 224 2 0 2 0 0 hsa-miR-4498 -0.23 -0.23 N/A

NIPA1 ENST00000337435.4 non imprinted in Prader-Willi/Angelman syndrome 1 805 2 0 1 1 0 hsa-miR-4498 -0.23 -0.23 N/A sema domain, immunoglobulin domain (Ig), transmembrane SEMA4C ENST00000305476.5 31 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A domain (TM) and short cytoplasmic domain, (semaphorin) NES ENST00000368223.3 nestin 385 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

SLC23A3 ENST00000396775.3 solute carrier family 23, member 3 9 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A low density lipoprotein receptor-related protein associated LRPAP1 ENST00000500728.2 1109 3 1 1 1 3 hsa-miR-4498 -0.23 -0.54 N/A protein 1 MMGT1 ENST00000305963.2 membrane magnesium transporter 1 113 1 1 0 0 0 hsa-miR-4498 -0.23 -0.24 N/A

CORO1B ENST00000393893.1 coronin, actin binding protein, 1B 58 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.25 N/A MYC-associated zinc finger protein (purine-binding MAZ ENST00000219782.6 1711 1 0 1 0 2 hsa-miR-4498 -0.23 -0.24 N/A transcription factor) GREB1 ENST00000381486.2 growth regulation by estrogen in breast cancer 1 40 1 1 0 0 1 hsa-miR-5001-5p -0.23 -0.23 N/A

UGT3A1 ENST00000274278.3 UDP glycosyltransferase 3 family, polypeptide A1 90 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

GCHFR ENST00000260447.4 GTP cyclohydrolase I feedback regulator 3513 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

SBNO2 ENST00000361757.3 strawberry notch homolog 2 (Drosophila) 270 1 0 1 0 1 hsa-miR-4498 -0.23 -0.23 N/A

TVP23C-CDRT4 ENST00000522212.2 TVP23C-CDRT4 readthrough 109 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

DLGAP2 ENST00000421627.2 discs, large (Drosophila) homolog-associated protein 2 5 3 0 3 0 2 hsa-miR-4498 -0.23 -0.23 N/A

CNTNAP1 ENST00000264638.4 contactin associated protein 1 821 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score HOXB5 ENST00000239151.5 homeobox B5 55 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A solute carrier family 22 (organic anion/urate transporter), SLC22A12 ENST00000377567.2 5 2 1 1 0 1 hsa-miR-4498 -0.23 -0.59 N/A member 12 TMEM164 ENST00000372073.1 transmembrane protein 164 711 2 1 1 0 2 hsa-miR-5001-5p -0.23 -0.26 N/A

PKP3 ENST00000331563.2 plakophilin 3 167 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

HSPB7 ENST00000411503.1 heat shock 27kDa protein family, member 7 (cardiovascular) 5 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

SH3GL2 ENST00000380607.4 SH3-domain GRB2-like 2 125 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

STK32B ENST00000282908.5 serine/threonine kinase 32B 196 1 0 1 0 1 hsa-miR-4498 -0.23 -0.23 N/A

ZNF705B ENST00000443676.1 zinc finger protein 705B 5 1 0 0 1 2 hsa-miR-4498 -0.23 -0.23 N/A

ANXA8L1 ENST00000358140.4 annexin A8-like 1 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

ANXA8L2 ENST00000340243.6 annexin A8-like 2 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

ANXA8 ENST00000357718.4 annexin A8 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

PYROXD1 ENST00000240651.9 pyridine nucleotide-disulphide oxidoreductase domain 1 5 2 0 0 2 0 hsa-miR-5001-5p -0.23 -0.23 N/A

RCC1 ENST00000373833.6 regulator of chromosome condensation 1 1156 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

ZNF629 ENST00000262525.4 zinc finger protein 629 44 1 1 0 0 2 hsa-miR-5001-5p -0.23 -0.23 N/A

ZGLP1 ENST00000403903.3 zinc finger, GATA-like protein 1 7 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A biogenesis of lysosomal organelles complex-1, subunit 6, BLOC1S6 ENST00000220531.3 1754 1 0 1 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A pallidin COPZ1 ENST00000551779.1 coatomer protein complex, subunit zeta 1 2623 2 0 1 1 0 hsa-miR-4498 -0.23 -0.35 N/A

LDB1 ENST00000361198.5 LIM domain binding 1 61 1 0 1 0 3 hsa-miR-4498 -0.23 -0.27 N/A

CERS1 ENST00000427170.2 ceramide synthase 1 167 1 0 0 1 1 hsa-miR-762 -0.23 -0.23 N/A

CD93 ENST00000246006.4 CD93 molecule 5 1 0 0 1 2 hsa-miR-5001-5p -0.23 -0.23 N/A

CELF5 ENST00000541430.2 CUGBP, Elav-like family member 5 5 1 0 1 0 1 hsa-miR-4498 -0.23 -0.23 N/A

DLX2 ENST00000234198.4 distal-less homeobox 2 653 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

TNFRSF13C ENST00000291232.3 tumor necrosis factor receptor superfamily, member 13C 36 2 0 2 0 3 hsa-miR-5001-5p -0.23 -0.37 N/A

PPP1R15B ENST00000367188.4 protein phosphatase 1, regulatory subunit 15B 2154 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

ENDOV ENST00000323854.5 endonuclease V 79 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF720 ENST00000534369.1 zinc finger protein 720 19 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

ZFP14 ENST00000270001.7 ZFP14 zinc finger protein 109 2 1 1 0 0 hsa-miR-5001-5p -0.23 -0.44 N/A

MRAS ENST00000289104.4 muscle RAS oncogene homolog 181 2 0 1 1 0 hsa-miR-4498 -0.23 -0.28 N/A

AIP ENST00000279146.3 aryl hydrocarbon receptor interacting protein 2469 1 0 1 0 1 hsa-miR-4498 -0.23 -0.28 N/A

DCAF12 ENST00000361264.4 DDB1 and CUL4 associated factor 12 2075 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

AGXT ENST00000307503.3 alanine-glyoxylate aminotransferase 365 1 0 1 0 1 hsa-miR-5001-5p -0.23 -0.23 N/A

CHRNB2 ENST00000368476.3 cholinergic receptor, nicotinic, beta 2 (neuronal) 16 1 1 0 0 4 hsa-miR-5001-5p -0.23 -0.23 N/A

ITFG3 ENST00000600536.1 Protein ITFG3; Uncharacterized protein; cDNA FLJ60496 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

TADA2B ENST00000310074.7 transcriptional adaptor 2B 38 1 0 1 0 1 hsa-miR-5001-5p -0.23 -0.23 N/A

ITM2C ENST00000326407.6 integral membrane protein 2C 67220 2 0 0 2 1 hsa-miR-5001-5p -0.23 -0.23 N/A

TAS1R3 ENST00000339381.5 taste receptor, type 1, member 3 7 1 0 0 1 1 hsa-miR-5001-5p -0.23 -0.23 N/A

WNT10B ENST00000407467.1 wingless-type MMTV integration site family, member 10B 13 1 0 1 0 1 hsa-miR-4498 -0.23 -0.23 N/A

VILL ENST00000283713.6 villin-like 84 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

RAD9A ENST00000307980.2 RAD9 homolog A (S. pombe) 38 1 0 1 0 2 hsa-miR-5001-5p -0.23 -0.23 N/A

EPHA10 ENST00000373048.4 EPH receptor A10 11 2 0 2 0 2 hsa-miR-4498 -0.23 -0.23 N/A HCG1774533, isoform CRA_a; PRO2268; Uncharacterized AC124890.1 ENST00000399333.3 15 1 0 0 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A protein C3orf27 ENST00000356020.2 chromosome 3 open reading frame 27 5 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

FZD8 ENST00000374694.1 frizzled family receptor 8 791 1 0 1 0 0 hsa-miR-4498 -0.23 -0.23 N/A

CDC14A ENST00000370125.2 cell division cycle 14A 123 1 0 1 0 2 hsa-miR-5001-5p -0.23 -0.23 N/A

CELF1 ENST00000395290.2 CUGBP, Elav-like family member 1 153 2 0 1 1 3 hsa-miR-4498 -0.23 -0.35 N/A

SFI1 ENST00000414585.1 Sfi1 homolog, spindle assembly associated (yeast) 692 1 1 0 0 0 hsa-miR-5001-5p -0.23 -0.23 N/A

NOL6 ENST00000455041.2 nucleolar protein 6 (RNA-associated) 404 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.27 N/A

MED29 ENST00000315588.5 mediator complex subunit 29 2453 2 1 0 1 2 hsa-miR-5001-5p -0.23 -0.54 N/A

ZNF460 ENST00000360338.3 zinc finger protein 460 164 4 0 0 4 0 hsa-miR-5001-5p -0.23 -0.25 N/A

SSBP3 ENST00000417664.2 single stranded DNA binding protein 3 1474 2 0 1 1 0 hsa-miR-4498 -0.23 -0.31 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PDZRN3 ENST00000263666.4 PDZ domain containing ring finger 3 146 1 0 0 1 0 hsa-miR-4498 -0.23 -0.23 N/A

DCLK2 ENST00000296550.7 doublecortin-like kinase 2 7 2 0 1 1 0 hsa-miR-5001-5p -0.23 -0.23 N/A

PIK3R3 ENST00000262741.5 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 335 1 0 1 0 1 hsa-miR-4498 -0.22 -0.25 N/A

MAPK1 ENST00000215832.6 mitogen-activated protein kinase 1 630 2 1 1 0 4 hsa-miR-5001-5p -0.22 -0.31 N/A

RP11-204N11.1 ENST00000555187.1 Uncharacterized protein 5 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

NOTUM ENST00000409678.3 notum pectinacetylesterase homolog (Drosophila) 10 1 0 0 1 0 hsa-miR-762 -0.22 -0.22 N/A

LTF ENST00000231751.4 lactotransferrin 5 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

GBA2 ENST00000378088.1 glucosidase, beta (bile acid) 2 19 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

KANSL2 ENST00000550347.1 KAT8 regulatory NSL complex subunit 2 68 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

RHOJ ENST00000316754.3 ras homolog family member J 118 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

SHANK1 ENST00000391813.1 SH3 and multiple ankyrin repeat domains 1 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

RTN2 ENST00000245923.4 reticulon 2 254 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

XPO6 ENST00000565698.1 exportin 6 413 1 0 1 0 0 hsa-miR-4498 -0.22 -0.23 N/A

ATP4A ENST00000262623.3 ATPase, H+/K+ exchanging, alpha polypeptide 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

CYTH1 ENST00000585509.1 cytohesin 1 553 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

KLF13 ENST00000307145.3 Kruppel-like factor 13 5 2 0 2 0 3 hsa-miR-4498 -0.22 -0.22 N/A

KLHL26 ENST00000300976.4 kelch-like family member 26 238 2 0 2 0 1 hsa-miR-4498 -0.22 -0.32 N/A

PTDSS2 ENST00000308020.5 phosphatidylserine synthase 2 1031 2 0 2 0 4 hsa-miR-5001-5p -0.22 -0.34 N/A

KIRREL ENST00000368172.1 kin of IRRE like (Drosophila) 493 1 1 0 0 1 hsa-miR-5001-5p -0.22 -0.22 N/A

SYK ENST00000375754.4 spleen tyrosine kinase 25 2 0 2 0 0 hsa-miR-4498 -0.22 -0.22 N/A

BPTF ENST00000321892.4 bromodomain PHD finger transcription factor 7 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A leucine rich transmembrane and O-methyltransferase domain LRTOMT ENST00000324866.7 313 1 0 1 0 0 hsa-miR-5001-5p -0.22 -0.32 N/A containing UTP11L ENST00000537711.1 UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) 1460 1 1 0 0 0 hsa-miR-5001-5p -0.22 -0.41 N/A

HEMK1 ENST00000232854.4 HemK methyltransferase family member 1 99 3 0 2 1 2 hsa-miR-4498 -0.22 -0.43 N/A

MAPK13 ENST00000373766.5 mitogen-activated protein kinase 13 499 1 0 0 1 4 hsa-miR-4498 -0.22 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MMP15 ENST00000219271.3 matrix metallopeptidase 15 (membrane-inserted) 605 2 2 0 0 5 hsa-miR-5001-5p -0.22 -0.27 N/A

ASAP3 ENST00000495646.1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 196 1 0 1 0 1 hsa-miR-4498 -0.22 -0.31 N/A

DRD2 ENST00000355319.2 dopamine receptor D2 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

KRT8 ENST00000552551.1 keratin 8 13 1 0 0 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

BET1L ENST00000325147.9 Bet1 golgi vesicular membrane trafficking protein-like 702 1 0 1 0 3 hsa-miR-4498 -0.22 -0.22 N/A

YEATS2 ENST00000305135.5 YEATS domain containing 2 499 2 0 2 0 0 hsa-miR-4498 -0.22 -0.22 N/A

DCAF16 ENST00000382247.1 DDB1 and CUL4 associated factor 16 202 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

CHADL ENST00000216241.9 chondroadherin-like 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

ARMS2 ENST00000528446.1 age-related maculopathy susceptibility 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

COL2A1 ENST00000380518.3 collagen, type II, alpha 1 1518 1 1 0 0 0 hsa-miR-4498 -0.22 -0.23 N/A

CHD5 ENST00000262450.3 chromodomain helicase DNA binding protein 5 5 4 0 2 2 3 hsa-miR-5001-5p -0.22 -0.22 N/A

NPAS2 ENST00000335681.5 neuronal PAS domain protein 2 559 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.3 N/A

COL9A2 ENST00000372748.3 collagen, type IX, alpha 2 189 3 1 1 1 3 hsa-miR-4498 -0.22 -0.45 N/A

C2CD2 ENST00000329623.7 C2 calcium-dependent domain containing 2 106 1 0 1 0 1 hsa-miR-4498 -0.22 -0.33 N/A proline rich Gla (G-carboxyglutamic acid) 3 PRRG3 ENST00000370353.3 5 2 0 2 0 3 hsa-miR-4498 -0.22 -0.22 N/A (transmembrane) NDEL1 ENST00000402554.3 nudE neurodevelopment protein 1-like 1 396 2 0 2 0 0 hsa-miR-4498 -0.22 -0.22 N/A

ERVV-2 ENST00000601417.1 endogenous retrovirus group V, member 2 5 1 0 0 1 0 hsa-miR-4498 -0.22 -0.22 N/A

TSPEAR ENST00000323084.4 thrombospondin-type laminin G domain and EAR repeats 5 1 0 0 1 2 hsa-miR-5001-5p -0.22 -0.22 N/A

GCLC ENST00000229416.6 glutamate-cysteine ligase, catalytic subunit 1001 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A extracellular leucine-rich repeat and fibronectin type III ELFN1 ENST00000424383.2 5 1 1 0 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A domain containing 1 AP000708.1 ENST00000527818.1 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- GALNT6 ENST00000543196.2 83 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A acetylgalactosaminyltransferase 6 (GalNAc-T6) apolipoprotein B mRNA editing enzyme, catalytic APOBEC3C ENST00000361441.4 14 1 0 1 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A polypeptide-like 3C DNAJC5 ENST00000360864.4 DnaJ (Hsp40) homolog, subfamily C, member 5 1089 1 1 0 0 1 hsa-miR-5001-5p -0.22 -0.35 N/A

DTX2 ENST00000413936.2 deltex homolog 2 (Drosophila) 76 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score XCR1 ENST00000309285.3 chemokine (C motif) receptor 1 5 2 0 1 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- MGAT4B ENST00000337755.5 533 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A acetylglucosaminyltransferase, isozyme B ITK ENST00000422843.3 IL2-inducible T-cell kinase 5 1 1 0 0 1 hsa-miR-5001-5p -0.22 -0.22 N/A

TMEM8A ENST00000431232.2 transmembrane protein 8A 2174 2 0 2 0 0 hsa-miR-4498 -0.22 -0.31 N/A

RNH1 ENST00000534797.1 ribonuclease/angiogenin inhibitor 1 11419 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

GPR133 ENST00000376682.4 G protein-coupled receptor 133 57 2 0 0 2 2 hsa-miR-5001-5p -0.22 -0.22 N/A

C11orf53 ENST00000280325.4 chromosome 11 open reading frame 53 45 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

GEMIN6 ENST00000409011.1 gem (nuclear organelle) associated protein 6 257 1 0 0 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

MAOB ENST00000538942.1 monoamine oxidase B 32 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

FBXO48 ENST00000377957.3 F-box protein 48 13 2 1 1 0 0 hsa-miR-4498 -0.22 -0.64 N/A

SMG7 ENST00000367537.3 SMG7 nonsense mediated mRNA decay factor 305 1 0 1 0 2 hsa-miR-4498 -0.22 -0.22 N/A

RASSF4 ENST00000374417.2 Ras association (RalGDS/AF-6) domain family member 4 515 3 0 3 0 3 hsa-miR-5001-5p -0.22 -0.41 N/A

MYH11 ENST00000452625.2 myosin, heavy chain 11, smooth muscle 5 1 1 0 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A

ARL8A ENST00000272217.2 ADP-ribosylation factor-like 8A 272 1 0 1 0 3 hsa-miR-4498 -0.22 -0.27 N/A

FUT11 ENST00000394790.1 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 622 1 0 1 0 0 hsa-miR-4498 -0.22 -0.25 N/A

SIRT3 ENST00000382743.4 sirtuin 3 408 2 0 2 0 0 hsa-miR-5001-5p -0.22 -0.24 N/A

BOD1L1 ENST00000040738.5 biorientation of chromosomes in cell division 1-like 1 46 1 1 0 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A

ESRRA ENST00000405666.1 estrogen-related receptor alpha 18 1 0 1 0 2 hsa-miR-4498 -0.22 -0.22 N/A

SYT15 ENST00000374323.4 synaptotagmin XV 5 2 0 2 0 3 hsa-miR-5001-5p -0.22 -0.22 N/A

MYT1 ENST00000328439.1 myelin transcription factor 1 12 1 1 0 0 1 hsa-miR-5001-5p -0.22 -0.22 N/A

LAPTM5 ENST00000294507.3 lysosomal protein transmembrane 5 5 1 0 0 1 3 hsa-miR-5001-5p -0.22 -0.22 N/A

VSTM5 ENST00000409977.1 V-set and transmembrane domain containing 5 5 1 0 1 0 2 hsa-miR-4498 -0.22 -0.22 N/A

TGIF2 ENST00000373874.2 TGFB-induced factor homeobox 2 192 2 0 1 1 0 hsa-miR-4498 -0.22 -0.5 N/A

MAU2 ENST00000262815.8 MAU2 sister chromatid cohesion factor 5234 2 1 1 0 0 hsa-miR-4498 -0.22 -0.23 N/A

GRAMD3 ENST00000285689.3 GRAM domain containing 3 232 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score BARX2 ENST00000281437.4 BARX homeobox 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

RGS12 ENST00000538395.1 regulator of G-protein signaling 12 635 2 0 2 0 2 hsa-miR-4498 -0.22 -0.22 N/A

AMPD2 ENST00000342115.4 adenosine monophosphate deaminase 2 216 1 1 0 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A

IRS2 ENST00000375856.3 insulin receptor substrate 2 231 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

AC137932.1 ENST00000602042.1 5 2 0 1 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

MACROD2 ENST00000217246.4 MACRO domain containing 2 5 2 0 1 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

SFXN5 ENST00000410065.1 sideroflexin 5 56 3 2 0 1 2 hsa-miR-5001-5p -0.22 -0.61 N/A

TIAF1 ENST00000408971.2 TGFB1-induced anti-apoptotic factor 1 152 2 0 1 1 0 hsa-miR-4498 -0.22 -0.32 N/A

MUL1 ENST00000264198.3 mitochondrial E3 ubiquitin protein ligase 1 812 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, MMP2 ENST00000219070.4 2187 1 0 0 1 2 hsa-miR-4498 -0.22 -0.22 N/A 72kDa type IV collagenase) CTLA4 ENST00000427473.2 cytotoxic T-lymphocyte-associated protein 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

LYPD6 ENST00000334166.4 LY6/PLAUR domain containing 6 261 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

DUOX2 ENST00000389039.6 dual oxidase 2 5 2 0 2 0 3 hsa-miR-4498 -0.22 -0.22 N/A

SYNDIG1 ENST00000376862.3 synapse differentiation inducing 1 5 1 0 1 0 0 hsa-miR-5001-5p -0.22 -0.22 N/A

RARG ENST00000425354.2 retinoic acid receptor, gamma 21 1 0 1 0 1 hsa-miR-4498 -0.22 -0.22 N/A

CYP3A4 ENST00000354593.2 cytochrome P450, family 3, subfamily A, polypeptide 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

PTGIS ENST00000244043.4 prostaglandin I2 (prostacyclin) synthase 192 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

CTD-3074O7.11 ENST00000419755.3 Bardet-Biedl syndrome 1 protein 523 2 0 1 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

YIF1B ENST00000337679.8 Yip1 interacting factor homolog B (S. cerevisiae) 3087 3 0 3 0 2 hsa-miR-4498 -0.22 -0.47 N/A

TMEM138 ENST00000278826.6 transmembrane protein 138 1694 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

EFNA4 ENST00000368409.3 ephrin-A4 125 1 0 0 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

GINS3 ENST00000318129.5 GINS complex subunit 3 (Psf3 homolog) 262 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

TBC1D3G ENST00000330458.7 TBC1 domain family, member 3G 5 1 0 1 0 0 hsa-miR-4498 -0.22 -0.22 N/A

HHLA2 ENST00000357759.5 HERV-H LTR-associating 2 5 2 0 0 2 0 hsa-miR-5001-5p -0.22 -0.22 N/A

RAX2 ENST00000555978.1 retina and anterior neural fold homeobox 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SSNA1 ENST00000322310.5 Sjogren syndrome nuclear autoantigen 1 160 1 0 0 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

RREB1 ENST00000379938.2 ras responsive element binding protein 1 340 1 0 0 1 1 hsa-miR-5001-5p -0.22 -0.22 N/A

BBS1 ENST00000393994.2 Bardet-Biedl syndrome 1 523 2 0 1 1 0 hsa-miR-5001-5p -0.22 -0.22 N/A

KCNK5 ENST00000359534.3 potassium channel, subfamily K, member 5 143 4 1 2 1 0 hsa-miR-5001-5p -0.22 -0.37 N/A

PADI2 ENST00000375486.4 peptidyl arginine deiminase, type II 11 3 1 2 0 1 hsa-miR-5001-5p -0.22 -0.53 N/A

NMT1 ENST00000592782.1 N-myristoyltransferase 1 1991 2 1 1 0 2 hsa-miR-4498 -0.22 -0.23 N/A

DPYSL2 ENST00000311151.5 dihydropyrimidinase-like 2 3087 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A HSPA (heat shock 70kDa) binding protein, cytoplasmic HSPBP1 ENST00000255631.5 368 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A cochaperone 1 RPH3A ENST00000415485.3 rabphilin 3A homolog (mouse) 5 1 0 0 1 1 hsa-miR-5001-5p -0.21 -0.21 N/A

LMLN ENST00000330198.4 leishmanolysin-like (metallopeptidase M8 family) 18 2 0 1 1 0 hsa-miR-5001-5p -0.21 -0.23 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ2 ENST00000243457.3 5 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A 2 MS4A7 ENST00000358246.1 membrane-spanning 4-domains, subfamily A, member 7 5 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

BTBD2 ENST00000255608.4 BTB (POZ) domain containing 2 77 1 0 0 1 2 hsa-miR-5001-5p -0.21 -0.21 N/A

RP11-817J15.3 ENST00000537079.1 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

C15orf52 ENST00000397536.2 chromosome 15 open reading frame 52 14 1 0 0 1 2 hsa-miR-5001-5p -0.21 -0.21 N/A

UBOX5 ENST00000217173.2 U-box domain containing 5 76 2 0 1 1 1 hsa-miR-4498 -0.21 -0.38 N/A

KAZALD1 ENST00000370200.5 Kazal-type serine peptidase inhibitor domain 1 186 2 0 2 0 0 hsa-miR-4498 -0.21 -0.24 N/A

SLC25A45 ENST00000527174.1 solute carrier family 25, member 45 67 1 0 1 0 2 hsa-miR-4498 -0.21 -0.26 N/A

PLXDC1 ENST00000315392.4 plexin domain containing 1 9 2 0 0 2 3 hsa-miR-5001-5p -0.21 -0.37 N/A

ZER1 ENST00000291900.2 zyg-11 related, cell cycle regulator 336 2 1 0 1 3 hsa-miR-5001-5p -0.21 -0.29 N/A

CDC20B ENST00000334206.5 cell division cycle 20B 5 2 0 1 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

CYBRD1 ENST00000375252.3 cytochrome b reductase 1 4467 1 0 1 0 1 hsa-miR-4498 -0.21 -0.23 N/A

SMYD4 ENST00000305513.7 SET and MYND domain containing 4 53 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

CLEC3A ENST00000299642.4 C-type lectin domain family 3, member A 5 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

TRMT44 ENST00000389737.4 tRNA methyltransferase 44 homolog (S. cerevisiae) 62 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score WARS2 ENST00000369426.5 tryptophanyl tRNA synthetase 2, mitochondrial 205 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

RASGRF1 ENST00000558480.2 Ras protein-specific guanine nucleotide-releasing factor 1 5 2 2 0 0 0 hsa-miR-4498 -0.21 -0.21 N/A

LY6H ENST00000430474.2 lymphocyte antigen 6 complex, locus H 5 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

HOXC8 ENST00000040584.4 homeobox C8 5 1 0 1 0 2 hsa-miR-5001-5p -0.21 -0.21 N/A

INSRR ENST00000368195.3 insulin receptor-related receptor 5 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

FRMPD3 ENST00000276185.4 FERM and PDZ domain containing 3 0 2 1 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A

COX7B ENST00000481445.1 cytochrome c oxidase subunit VIIb 83 1 0 1 0 0 hsa-miR-4498 -0.21 -0.22 N/A

BCAT2 ENST00000545387.2 branched chain amino-acid transaminase 2, mitochondrial 4270 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

B4GALNT1 ENST00000341156.4 beta-1,4-N-acetyl-galactosaminyl transferase 1 23 1 0 1 0 0 hsa-miR-4498 -0.21 -0.24 N/A

HGFAC ENST00000382774.3 HGF activator 15 3 0 3 0 2 hsa-miR-4498 -0.21 -0.33 N/A

CELSR3 ENST00000164024.4 cadherin, EGF LAG seven-pass G-type receptor 3 13 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.24 N/A

UBXN10 ENST00000375099.3 UBX domain protein 10 5 1 0 1 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

CCDC68 ENST00000591504.1 coiled-coil domain containing 68 72 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

CDC37 ENST00000222005.2 cell division cycle 37 3905 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A

FOXP2 ENST00000408937.3 forkhead box P2 169 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A

WFDC5 ENST00000372789.4 WAP four-disulfide core domain 5 5 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

PHLDA3 ENST00000367311.3 pleckstrin homology-like domain, family A, member 3 82 2 0 2 0 2 hsa-miR-4498 -0.21 -0.56 N/A

KLF2 ENST00000248071.5 Kruppel-like factor 2 (lung) 431 3 0 2 1 4 hsa-miR-5001-5p -0.21 -0.56 N/A

NUGGC ENST00000413272.2 nuclear GTPase, germinal center associated 10 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

HLA-C ENST00000376228.5 major histocompatibility complex, class I, C 521 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

PRPF38A ENST00000257181.9 pre-mRNA processing factor 38A 892 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.22 N/A

ZNF180 ENST00000391956.4 zinc finger protein 180 195 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.3 N/A

PTGIR ENST00000291294.2 prostaglandin I2 (prostacyclin) receptor (IP) 20 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

CYFIP2 ENST00000318218.6 cytoplasmic FMR1 interacting protein 2 303 1 1 0 0 0 hsa-miR-4498 -0.21 -0.21 N/A

CAPN6 ENST00000324068.1 calpain 6 5 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AC110619.2 ENST00000404891.1 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

FANCC ENST00000289081.3 Fanconi anemia, complementation group C 408 2 0 0 2 0 hsa-miR-5001-5p -0.21 -0.21 N/A

TTC1 ENST00000231238.5 tetratricopeptide repeat domain 1 1052 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

RAB26 ENST00000210187.6 RAB26, member RAS oncogene family 799 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

YARS ENST00000373477.4 tyrosyl-tRNA synthetase 1227 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

FA2H ENST00000219368.3 fatty acid 2-hydroxylase 5 2* 0 0 1 4 hsa-miR-4498 -0.21 -0.21 N/A

VEGFB ENST00000309422.2 vascular endothelial growth factor B 4432 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

FAHD2B ENST00000414820.1 fumarylacetoacetate hydrolase domain containing 2B 8 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

STK10 ENST00000176763.5 serine/threonine kinase 10 655 1 0 1 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

MET ENST00000397752.3 met proto-oncogene 1155 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A SWI/SNF related, matrix associated, actin dependent SMARCD1 ENST00000394963.4 952 2 0 2 0 0 hsa-miR-4498 -0.21 -0.22 N/A regulator of chromatin, subfamily d, member 1 UGCG ENST00000374279.3 UDP-glucose ceramide glucosyltransferase 1200 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.22 N/A

EPS8L2 ENST00000318562.8 EPS8-like 2 1419 2 0 1 1 0 hsa-miR-4498 -0.21 -0.22 N/A

FOXO1 ENST00000379561.5 forkhead box O1 480 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.23 N/A

MEP1A ENST00000230588.4 meprin A, alpha (PABA peptide hydrolase) 8 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

IL16 ENST00000394660.2 interleukin 16 5 1 0 0 1 2 hsa-miR-5001-5p -0.21 -0.21 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ9 ENST00000368088.3 5 2 0 0 2 1 hsa-miR-5001-5p -0.21 -0.21 N/A 9 OMP ENST00000529803.1 olfactory marker protein 9 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

KIFC2 ENST00000301331.5 kinesin family member C2 101 2 0 2 0 1 hsa-miR-4498 -0.21 -0.21 N/A

ACACB ENST00000543201.1 acetyl-CoA carboxylase beta 59 2 0 0 2 1 hsa-miR-5001-5p -0.21 -0.21 N/A

FBXL22 ENST00000360587.2 F-box and leucine-rich repeat protein 22 65 1 0 0 1 2 hsa-miR-4498 -0.21 -0.23 N/A

AES ENST00000221561.8 amino-terminal enhancer of split 380 1 1 0 0 2 hsa-miR-5001-5p -0.21 -0.21 N/A

FLOT2 ENST00000394906.2 flotillin 2 37 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

MS4A14 ENST00000531787.1 membrane-spanning 4-domains, subfamily A, member 14 5 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

PAOX ENST00000368539.4 polyamine oxidase (exo-N4-amino) 264 3 1 0 2 2 hsa-miR-5001-5p -0.21 -0.78 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ANKRD33B ENST00000296657.5 ankyrin repeat domain 33B 9 5 0 2 3 5 hsa-miR-5001-5p -0.21 -0.55 N/A

ADIPOR1 ENST00000340990.5 adiponectin receptor 1 1538 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

SLC19A1 ENST00000311124.4 solute carrier family 19 (folate transporter), member 1 463 4 1 3 0 2 hsa-miR-4498 -0.21 -1.22 N/A

PDPK1 ENST00000441549.3 3-phosphoinositide dependent protein kinase-1 104 2 0 2 0 1 hsa-miR-5001-5p -0.21 -0.22 N/A

GIMAP5 ENST00000358647.3 GTPase, IMAP family member 5 5 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

CD99 ENST00000381192.3 CD99 molecule 5 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

PKDCC ENST00000294964.5 protein kinase domain containing, cytoplasmic 123 1 1 0 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

CHRNB1 ENST00000306071.2 cholinergic receptor, nicotinic, beta 1 (muscle) 56 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A solute carrier family 22 (organic anion transporter), member SLC22A8 ENST00000336232.2 5 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A 8 potassium voltage-gated channel, Isk-related family, member KCNE3 ENST00000310128.4 16 1 1 0 0 1 hsa-miR-5001-5p -0.21 -0.62 N/A 3 ALKBH4 ENST00000292566.3 alkB, alkylation repair homolog 4 (E. coli) 54 1 0 1 0 1 hsa-miR-4498 -0.21 -0.28 N/A nuclear factor of activated T-cells, cytoplasmic, calcineurin- NFATC4 ENST00000413692.2 73 3 0 3 0 2 hsa-miR-4498 -0.21 -0.35 N/A dependent 4 ZBTB38 ENST00000514251.1 zinc finger and BTB domain containing 38 1270 2 0 1 1 0 hsa-miR-4498 -0.21 -0.21 N/A

EIF5A2 ENST00000474096.1 eukaryotic translation initiation factor 5A2 443 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.23 N/A

RNF166 ENST00000312838.4 ring finger protein 166 1977 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

MYO7A ENST00000409709.3 myosin VIIA 64 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

ZDHHC9 ENST00000357166.6 zinc finger, DHHC-type containing 9 1203 2 0 1 1 0 hsa-miR-4498 -0.21 -0.27 N/A

C1QTNF6 ENST00000337843.2 C1q and tumor necrosis factor related protein 6 30 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

SMAD7 ENST00000262158.2 SMAD family member 7 142 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A

MTTP ENST00000457717.1 microsomal triglyceride transfer protein 32 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

PKP1 ENST00000367324.3 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 12 2 1 1 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

PPAP2C ENST00000269812.3 phosphatidic acid phosphatase type 2C 421 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

SYNGAP1 ENST00000418600.2 synaptic Ras GTPase activating protein 1 15 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

CRYL1 ENST00000298248.7 crystallin, lambda 1 158 1 0 0 1 1 hsa-miR-5001-5p -0.21 -0.21 N/A

DMWD ENST00000377735.3 dystrophia myotonica, WD repeat containing 229 2 1 1 0 0 hsa-miR-5001-5p -0.21 -0.48 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SH3GLB2 ENST00000372564.3 SH3-domain GRB2-like endophilin B2 535 3 0 1 2 4 hsa-miR-4498 -0.21 -0.45 N/A

NSFL1C ENST00000353088.2 NSFL1 (p97) cofactor (p47) 397 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT1 ENST00000252674.7 33 3 1 1 1 4 hsa-miR-4498 -0.21 -0.29 N/A homolog, Drosophila); translocated to, 1 C2CD3 ENST00000334126.7 C2 calcium-dependent domain containing 3 605 1 0 0 1 0 hsa-miR-762 -0.21 -0.21 N/A

LAT2 ENST00000398475.1 linker for activation of T cells family, member 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.21 -0.21 N/A

PAX3 ENST00000350526.4 paired box 3 7 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

EFNB1 ENST00000204961.4 ephrin-B1 386 2 0 2 0 1 hsa-miR-4498 -0.21 -0.21 N/A

NHLH1 ENST00000302101.5 nescient helix loop helix 1 5 1 0 0 1 1 hsa-miR-4498 -0.21 -0.21 N/A

CCM2L ENST00000262659.8 cerebral cavernous malformation 2-like 7 1 0 0 1 2 hsa-miR-5001-5p -0.21 -0.21 N/A transient receptor potential cation channel, subfamily V, TRPV3 ENST00000301365.4 13 1 1 0 0 3 hsa-miR-5001-5p -0.21 -0.21 N/A member 3 UNC119 ENST00000301032.4 unc-119 homolog (C. elegans) 49 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A

N4BP3 ENST00000274605.5 NEDD4 binding protein 3 35 4 0 4 0 6 hsa-miR-4498 -0.21 -0.29 N/A

MSX2 ENST00000239243.6 msh homeobox 2 316 3 0 2 1 3 hsa-miR-4498 -0.21 -0.64 N/A

IGFBP4 ENST00000269593.4 insulin-like growth factor binding protein 4 4053 1 0 0 1 3 hsa-miR-4498 -0.21 -0.26 N/A

KIF6 ENST00000287152.7 kinesin family member 6 12 4 2 1 1 5 hsa-miR-5001-5p -0.21 -0.54 N/A

RAB36 ENST00000263116.2 RAB36, member RAS oncogene family 7 1 0 1 0 2 hsa-miR-4498 -0.21 -0.21 N/A

IFITM5 ENST00000382614.2 interferon induced transmembrane protein 5 5 1 0 1 0 0 hsa-miR-4498 -0.21 -0.21 N/A

CNTFR ENST00000351266.4 ciliary neurotrophic factor receptor 19 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

SMAD3 ENST00000327367.4 SMAD family member 3 1140 1 1 0 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

DGCR6L ENST00000248879.3 DiGeorge syndrome critical region gene 6-like 18 5 1 3 1 4 hsa-miR-4498 -0.21 -0.94 N/A

ITGA5 ENST00000293379.4 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 5599 1 1 0 0 1 hsa-miR-5001-5p -0.21 -0.21 N/A

SLC25A34 ENST00000294454.5 solute carrier family 25, member 34 5 1 0 1 0 1 hsa-miR-4498 -0.21 -0.21 N/A

CLDN10 ENST00000376873.3 claudin 10 7 1 0 1 0 0 hsa-miR-4498 -0.21 -0.28 N/A

LINGO4 ENST00000368820.3 leucine rich repeat and Ig domain containing 4 5 1 0 1 0 0 hsa-miR-5001-5p -0.21 -0.21 N/A

TBC1D16 ENST00000310924.2 TBC1 domain family, member 16 556 6 1 2 3 5 hsa-miR-5001-5p -0.21 -0.6 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ARP1 actin-related protein 1 homolog A, centractin alpha ACTR1A ENST00000487599.1 190 1 1 0 0 0 hsa-miR-5001-5p -0.21 -0.27 N/A (yeast) TSR2 ENST00000375151.4 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 233 1 0 0 1 0 hsa-miR-5001-5p -0.21 -0.21 N/A translocase of inner mitochondrial membrane 17 homolog B TIMM17B ENST00000465150.2 35084 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A (yeast) KIAA1161 ENST00000297625.7 KIAA1161 18 1 0 0 1 1 hsa-miR-4498 -0.2 -0.2 N/A

ZNF561 ENST00000326044.5 zinc finger protein 561 156 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

PLXNB2 ENST00000449103.1 plexin B2 82 2 0 2 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

BEND3 ENST00000369042.1 BEN domain containing 3 13 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A membrane-associated ring finger (C3HC4) 4, E3 ubiquitin MARCH4 ENST00000273067.4 68 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A protein ligase NID1 ENST00000366595.3 nidogen 1 303 1 1 0 0 1 hsa-miR-5001-5p -0.2 -0.2 N/A

CAPN10 ENST00000404753.3 calpain 10 279 1 0 1 0 1 hsa-miR-4498 -0.2 -0.2 N/A

SSTR5 ENST00000397547.2 somatostatin receptor 5 5 2 1 1 0 2 hsa-miR-5001-5p -0.2 -0.2 N/A

TP73 ENST00000378280.1 tumor protein p73 831 2 0 0 2 2 hsa-miR-5001-5p -0.2 -0.21 N/A

NOL9 ENST00000377705.5 nucleolar protein 9 194 2 1 0 1 0 hsa-miR-5001-5p -0.2 -0.38 N/A

PAX1 ENST00000444366.2 paired box 1 5 3 0 3 0 1 hsa-miR-4498 -0.2 -0.42 N/A

CSRNP2 ENST00000228515.1 cysteine-serine-rich nuclear protein 2 104 1 0 1 0 0 hsa-miR-4498 -0.2 -0.23 N/A

PTCH1 ENST00000430669.2 patched 1 123 1 0 1 0 2 hsa-miR-4498 -0.2 -0.21 N/A

EMP1 ENST00000256951.5 epithelial membrane protein 1 814 3 0 2 1 0 hsa-miR-4498 -0.2 -0.34 N/A

MOCS2 ENST00000450852.3 molybdenum cofactor synthesis 2 100 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A transcription factor AP-4 (activating enhancer binding TFAP4 ENST00000204517.6 13 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A protein 4) MAML3 ENST00000509479.2 mastermind-like 3 (Drosophila) 159 1 0 1 0 2 hsa-miR-4498 -0.2 -0.2 N/A WAP, follistatin/kazal, immunoglobulin, kunitz and netrin WFIKKN2 ENST00000311378.4 10 1 1 0 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A domain containing 2 AL590822.1 ENST00000545087.1 Uncharacterized protein 5 1 0 0 1 2 hsa-miR-5001-5p -0.2 -0.2 N/A

SMAP1 ENST00000370452.3 small ArfGAP 1 64 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

AC027307.3 ENST00000594262.1 Uncharacterized protein 5 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

KIF26B ENST00000366518.4 kinesin family member 26B 25 4 0 0 4 2 hsa-miR-5001-5p -0.2 -0.2 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GATAD2B ENST00000368655.4 GATA zinc finger domain containing 2B 48 2 1 0 1 0 hsa-miR-5001-5p -0.2 -0.49 N/A

FSTL4 ENST00000265342.7 follistatin-like 4 60 3 1 2 0 3 hsa-miR-4498 -0.2 -0.29 N/A

COLGALT1 ENST00000252599.4 collagen beta(1-O)galactosyltransferase 1 427 1 1 0 0 0 hsa-miR-5001-5p -0.2 -0.23 N/A

RRP7A ENST00000323013.6 ribosomal RNA processing 7 homolog A (S. cerevisiae) 522 1 0 1 0 4 hsa-miR-5001-5p -0.2 -0.36 N/A

FBLIM1 ENST00000375771.1 filamin binding LIM protein 1 581 1 0 0 1 0 hsa-miR-4498 -0.2 -0.2 N/A runt-related transcription factor 1; translocated to, 1 (cyclin RUNX1T1 ENST00000523629.1 9 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A D-related) SEC14L6 ENST00000402034.2 SEC14-like 6 (S. cerevisiae) 14 1 0 0 1 3 hsa-miR-4498 -0.2 -0.2 N/A

DLX1 ENST00000341900.6 distal-less homeobox 1 312 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

SHQ1 ENST00000325599.8 SHQ1, H/ACA ribonucleoprotein assembly factor 29 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

SOX13 ENST00000367204.1 SRY (sex determining region Y)-box 13 1061 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

EVI5L ENST00000270530.4 ecotropic viral integration site 5-like 15 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

BEST2 ENST00000553030.1 bestrophin 2 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

EHMT2 ENST00000395728.3 euchromatic histone-lysine N-methyltransferase 2 1379 1 0 0 1 1 hsa-miR-5001-5p -0.2 -0.2 N/A

ZNF844 ENST00000439326.3 zinc finger protein 844 11 1 1 0 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

IGF2BP1 ENST00000290341.3 insulin-like growth factor 2 mRNA binding protein 1 460 3 1 2 0 2 hsa-miR-4498 -0.2 -0.25 N/A

MDFI ENST00000373050.4 MyoD family inhibitor 14 1 0 1 0 0 hsa-miR-4498 -0.2 -0.33 N/A

TXNL4B ENST00000268483.3 thioredoxin-like 4B 200 1 0 1 0 0 hsa-miR-4498 -0.2 -0.21 N/A

EBF2 ENST00000535548.1 early B-cell factor 2 11 2 0 2 0 1 hsa-miR-4498 -0.2 -0.4 N/A

PTK6 ENST00000217185.2 protein tyrosine kinase 6 27 1 1 0 0 1 hsa-miR-5001-5p -0.2 -0.2 N/A

C17orf105 ENST00000449302.3 chromosome 17 open reading frame 105 5 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

FAM124A ENST00000322475.8 family with sequence similarity 124A 5 1 1 0 0 1 hsa-miR-4498 -0.2 -0.2 N/A

SAP30BP ENST00000584667.1 SAP30 binding protein 867 1 0 0 1 1 hsa-miR-4498 -0.2 -0.22 N/A

ZNF250 ENST00000292579.7 zinc finger protein 250 67 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

KDSR ENST00000406396.3 3-ketodihydrosphingosine reductase 322 1 1 0 0 1 hsa-miR-5001-5p -0.2 -0.28 N/A

HOXA4 ENST00000360046.5 homeobox A4 55 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.21 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MIEF1 ENST00000325301.2 mitochondrial elongation factor 1 2319 1 0 1 0 1 hsa-miR-4498 -0.2 -0.2 N/A solute carrier family 22 (organic cation transporter), member SLC22A18AS ENST00000533594.1 5 1 0 1 0 4 hsa-miR-4498 -0.2 -0.24 N/A 18 antisense HOMER2 ENST00000450735.2 homer homolog 2 (Drosophila) 12 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

KSR1 ENST00000398988.3 kinase suppressor of ras 1 256 1 0 1 0 3 hsa-miR-4498 -0.2 -0.21 N/A

PLD1 ENST00000342215.6 phospholipase D1, phosphatidylcholine-specific 128 2 0 0 2 0 hsa-miR-5001-5p -0.2 -0.21 N/A

AGO1 ENST00000373204.4 argonaute RISC catalytic component 1 402 2 0 2 0 1 hsa-miR-5001-5p -0.2 -0.21 N/A

TSHR ENST00000541158.2 thyroid stimulating hormone receptor 5 2 0 1 1 0 hsa-miR-5001-5p -0.2 -0.25 N/A DNA fragmentation factor, 40kDa, beta polypeptide DFFB ENST00000378209.3 55 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A (caspase-activated DNase) PDCD5 ENST00000419343.3 programmed cell death 5 158 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

PSCA ENST00000301258.4 prostate stem cell antigen 14 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A sema domain, transmembrane domain (TM), and SEMA6B ENST00000301293.3 35 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A cytoplasmic domain, (semaphorin) 6B ZNF749 ENST00000334181.4 zinc finger protein 749 69 1 0 1 0 2 hsa-miR-5001-5p -0.2 -0.2 N/A potassium voltage-gated channel, Shab-related subfamily, KCNB1 ENST00000371741.4 5 3 1 1 1 2 hsa-miR-5001-5p -0.2 -0.2 N/A member 1 PSMB11 ENST00000408907.2 proteasome (prosome, macropain) subunit, beta type, 11 5 1 0 0 1 1 hsa-miR-5001-5p -0.2 -0.2 N/A

ZNF500 ENST00000219478.6 zinc finger protein 500 14 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

SCYL2 ENST00000360820.2 SCY1-like 2 (S. cerevisiae) 425 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

GABRG2 ENST00000356592.3 gamma-aminobutyric acid (GABA) A receptor, gamma 2 24 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A potassium voltage-gated channel, shaker-related subfamily, KCNA6 ENST00000433855.1 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A member 6 FBF1 ENST00000586717.1 Fas (TNFRSF6) binding factor 1 86 1 0 1 0 1 hsa-miR-4498 -0.2 -0.2 N/A KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein KDELR1 ENST00000330720.2 675 3 0 2 1 3 hsa-miR-4498 -0.2 -0.52 N/A retention receptor 1 FAM83H ENST00000388913.3 family with sequence similarity 83, member H 39 2 0 1 1 1 hsa-miR-5001-5p -0.2 -0.27 N/A

CDC42EP2 ENST00000279249.2 CDC42 effector protein (Rho GTPase binding) 2 449 2 0 1 1 0 hsa-miR-5001-5p -0.2 -0.34 N/A

REXO1L1 ENST00000379010.2 REX1, RNA exonuclease 1 homolog (S. cerevisiae)-like 1 5 2 1 1 0 3 hsa-miR-5001-5p -0.2 -0.2 N/A

CRTC2 ENST00000368630.3 CREB regulated transcription coactivator 2 275 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

INSR ENST00000341500.5 insulin receptor 577 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GRK1 ENST00000335678.6 G protein-coupled receptor kinase 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.2 -0.2 N/A

C20orf197 ENST00000313426.1 chromosome 20 open reading frame 197 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

ZIC4 ENST00000383075.3 Zic family member 4 5 1 0 0 1 1 hsa-miR-4498 -0.2 -0.2 N/A

ARHGAP36 ENST00000370922.1 Rho GTPase activating protein 36 5 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

CTD-2267D19.3 ENST00000578774.1 Uncharacterized protein 110 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

PWWP2B ENST00000305233.5 PWWP domain containing 2B 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

PNPLA1 ENST00000388715.3 patatin-like phospholipase domain containing 1 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

ARHGAP6 ENST00000380736.1 Rho GTPase activating protein 6 12 1 1 0 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

FAM3A ENST00000434658.2 family with sequence similarity 3, member A 260 3 1 1 1 2 hsa-miR-762 -0.2 -0.59 N/A

HDGFRP3 ENST00000299633.4 Hepatoma-derived growth factor-related protein 3 2577 1 1 0 0 1 hsa-miR-5001-5p -0.2 -0.56 N/A

C6orf132 ENST00000341865.4 chromosome 6 open reading frame 132 17 1 0 1 0 1 hsa-miR-4498 -0.2 -0.59 N/A

C1RL ENST00000544702.1 complement component 1, r subcomponent-like 70 2 1 1 0 0 hsa-miR-5001-5p -0.2 -0.51 N/A

MAPKAPK3 ENST00000446044.1 mitogen-activated protein kinase-activated protein kinase 3 155 3 1 2 0 1 hsa-miR-4498 -0.2 -0.63 N/A

PPP1R9B ENST00000316878.6 protein phosphatase 1, regulatory subunit 9B 120 1 1 0 0 2 hsa-miR-5001-5p -0.2 -0.2 N/A

TSPAN9 ENST00000537971.1 tetraspanin 9 1410 3 0 3 0 0 hsa-miR-4498 -0.2 -0.4 N/A

MMP24 ENST00000246186.6 matrix metallopeptidase 24 (membrane-inserted) 201 1 0 0 1 2 hsa-miR-5001-5p -0.2 -0.2 N/A

TMBIM1 ENST00000258412.3 transmembrane BAX inhibitor motif containing 1 2201 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

BVES ENST00000314641.5 blood vessel epicardial substance 30 1 0 0 1 2 hsa-miR-5001-5p -0.2 -0.27 N/A

CCDC40 ENST00000397545.4 coiled-coil domain containing 40 34 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

BAI2 ENST00000398556.3 brain-specific angiogenesis inhibitor 2 30 1 0 0 1 0 hsa-miR-762 -0.2 -0.2 N/A

SAMD12 ENST00000409003.4 sterile alpha motif domain containing 12 57 2 0 0 2 3 hsa-miR-5001-5p -0.2 -0.2 N/A

MRI1 ENST00000319545.8 methylthioribose-1-phosphate isomerase 1 851 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

ZNF81 ENST00000338637.7 zinc finger protein 81 10 1 0 0 1 1 hsa-miR-4498 -0.2 -0.2 N/A

SHANK2 ENST00000449833.2 SH3 and multiple ankyrin repeat domains 2 26 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A guanine nucleotide binding protein (G protein), beta GNB2 ENST00000303210.4 2956 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A polypeptide 2 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SH2D5 ENST00000375031.1 SH2 domain containing 5 7 2 0 1 1 1 hsa-miR-4498 -0.2 -0.2 N/A

KIAA0355 ENST00000299505.6 KIAA0355 538 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

ZNF623 ENST00000501748.2 zinc finger protein 623 247 1 0 1 0 4 hsa-miR-4498 -0.2 -0.22 N/A

ARHGEF2 ENST00000368315.4 Rho/Rac guanine nucleotide exchange factor (GEF) 2 313 1 0 1 0 0 hsa-miR-4498 -0.2 -0.23 N/A

PRKCE ENST00000306156.3 protein kinase C, epsilon 164 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

ATP13A1 ENST00000291503.5 ATPase type 13A1 69 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

ST3GAL2 ENST00000342907.2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 102 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

AC139100.2 ENST00000588226.1 Uncharacterized protein 55 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

EIF4A1 ENST00000582746.1 eukaryotic translation initiation factor 4A1 44 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

FAM53A ENST00000489363.1 family with sequence similarity 53, member A 50 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

APOL1 ENST00000422706.1 apolipoprotein L, 1 5 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

IL2RB ENST00000216223.5 interleukin 2 receptor, beta 5 1 0 1 0 2 hsa-miR-5001-5p -0.2 -0.2 N/A

SLC16A12 ENST00000341233.4 solute carrier family 16, member 12 35 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

ZNF705D ENST00000400085.3 zinc finger protein 705D 5 1 0 0 1 2 hsa-miR-4498 -0.2 -0.2 N/A

TMEM248 ENST00000341567.4 transmembrane protein 248 3207 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

C6orf201 ENST00000380175.4 chromosome 6 open reading frame 201 5 1 0 0 1 0 hsa-miR-5001-5p -0.2 -0.2 N/A

MRPS18B ENST00000506373.2 mitochondrial ribosomal protein S18B 1667 1 0 1 0 0 hsa-miR-5001-5p -0.2 -0.2 N/A

CRB2 ENST00000373631.3 crumbs homolog 2 (Drosophila) 8 1 0 1 0 1 hsa-miR-4498 -0.2 -0.2 N/A

VAX1 ENST00000369206.5 ventral anterior homeobox 1 8 1 1 0 0 0 hsa-miR-5001-5p -0.2 -0.33 N/A

UBXN2B ENST00000399598.2 UBX domain protein 2B 157 1 0 1 0 0 hsa-miR-4498 -0.2 -0.2 N/A

ZFP36L2 ENST00000282388.3 ZFP36 ring finger protein-like 2 317 4 0 2 2 2 hsa-miR-4498 -0.19 -0.47 N/A

HS6ST3 ENST00000376705.2 heparan sulfate 6-O-sulfotransferase 3 598 2 0 1 1 2 hsa-miR-4498 -0.19 -0.2 N/A

MFAP2 ENST00000375534.3 microfibrillar-associated protein 2 10 1 0 1 0 4 hsa-miR-4498 -0.19 -0.3 N/A

PRKAR1B ENST00000537384.1 protein kinase, cAMP-dependent, regulatory, type I, beta 695 1 0 1 0 2 hsa-miR-4498 -0.19 -0.2 N/A

SLC44A2 ENST00000586078.1 solute carrier family 44 (choline transporter), member 2 720 2 0 2 0 0 hsa-miR-4498 -0.19 -0.31 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ITPKB ENST00000272117.3 inositol-trisphosphate 3-kinase B 5 2 0 2 0 1 hsa-miR-4498 -0.19 -0.19 N/A

UBE2O ENST00000319380.7 ubiquitin-conjugating enzyme E2O 239 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

POU3F3 ENST00000361360.2 POU class 3 homeobox 3 461 1 1 0 0 1 hsa-miR-5001-5p -0.19 -0.21 N/A

ELAVL3 ENST00000359227.3 ELAV like neuron-specific RNA binding protein 3 5 5 0 3 2 4 hsa-miR-5001-5p -0.19 -0.19 N/A

DGKG ENST00000265022.3 diacylglycerol kinase, gamma 90kDa 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

C17orf74 ENST00000574034.1 chromosome 17 open reading frame 74 8 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

AL049840.1 ENST00000429169.1 Uncharacterized protein; cDNA FLJ53535 5 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CLDN4 ENST00000435050.1 claudin 4 64 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

ADARB2 ENST00000381312.1 adenosine deaminase, RNA-specific, B2 (non-functional) 9 2 0 2 0 7 hsa-miR-4498 -0.19 -0.2 N/A solute carrier family 24 (sodium/potassium/calcium SLC24A4 ENST00000393265.2 5 2 1 1 0 0 hsa-miR-5001-5p -0.19 -0.23 N/A exchanger), member 4 solute carrier family 25 (mitochondrial carrier: glutamate), SLC25A22 ENST00000320230.5 319 2 0 2 0 0 hsa-miR-4498 -0.19 -0.19 N/A member 22 PPP1R18 ENST00000399199.3 protein phosphatase 1, regulatory subunit 18 265 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

KRT32 ENST00000225899.3 keratin 32 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

SLC39A14 ENST00000381237.1 solute carrier family 39 (zinc transporter), member 14 2413 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

AZU1 ENST00000233997.2 azurocidin 1 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

AP1G2 ENST00000308724.5 adaptor-related protein complex 1, gamma 2 subunit 149 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

HHIPL1 ENST00000330710.5 HHIP-like 1 29 2 0 2 0 0 hsa-miR-4498 -0.19 -0.27 N/A

EVPLL ENST00000399134.4 envoplakin-like 5 1 0 0 1 2 hsa-miR-5001-5p -0.19 -0.19 N/A

SNAI3 ENST00000332281.5 snail family zinc finger 3 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

SGSH ENST00000326317.6 N-sulfoglucosamine sulfohydrolase 109 2 1 1 0 1 hsa-miR-5001-5p -0.19 -0.19 N/A

LIMK2 ENST00000331728.4 LIM domain kinase 2 233 3 1 0 2 1 hsa-miR-5001-5p -0.19 -0.36 N/A

PODXL2 ENST00000342480.6 podocalyxin-like 2 155 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

STON1 ENST00000309835.3 stonin 1 254 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A potassium intermediate/small conductance calcium-activated KCNN1 ENST00000222249.9 11 3 0 3 0 1 hsa-miR-4498 -0.19 -0.39 N/A channel, subfamily N, member 1 BIRC5 ENST00000301633.4 baculoviral IAP repeat containing 5 3607 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.26 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ATG2A ENST00000421419.2 autophagy related 2A 3795 9 3 5 1 2 hsa-miR-5001-5p -0.19 -1.14 N/A

HSD11B1L ENST00000581893.1 hydroxysteroid (11-beta) dehydrogenase 1-like 211 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

GATA2 ENST00000341105.2 GATA binding protein 2 231 2 0 1 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

CLCN5 ENST00000376088.3 chloride channel, voltage-sensitive 5 154 4 2 1 1 0 hsa-miR-5001-5p -0.19 -0.48 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ12 ENST00000583088.1 9 2 0 2 0 5 hsa-miR-5001-5p -0.19 -0.19 N/A 12 LRG1 ENST00000306390.6 leucine-rich alpha-2-glycoprotein 1 1511 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

FNTB ENST00000246166.2 farnesyltransferase, CAAX box, beta 13 1 0 0 1 2 hsa-miR-5001-5p -0.19 -0.19 N/A immunoglobulin-like and fibronectin type III domain IGFN1 ENST00000295591.8 19 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A containing 1 CCDC141 ENST00000420890.2 coiled-coil domain containing 141 5 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

S1PR3 ENST00000358157.2 sphingosine-1-phosphate receptor 3 70 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

SCN3B ENST00000392770.2 sodium channel, voltage-gated, type III, beta subunit 10 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

ATG4B ENST00000405546.3 autophagy related 4B, cysteine peptidase 1444 2 0 2 0 1 hsa-miR-4498 -0.19 -0.32 N/A

QPCTL ENST00000012049.5 glutaminyl-peptide cyclotransferase-like 62 1 1 0 0 0 hsa-miR-5001-5p -0.19 -0.31 N/A

TNNI1 ENST00000361379.4 troponin I type 1 (skeletal, slow) 5 2 0 2 0 0 hsa-miR-4498 -0.19 -0.19 N/A

STARD5 ENST00000302824.6 StAR-related lipid transfer (START) domain containing 5 28 2 1 0 1 3 hsa-miR-5001-5p -0.19 -0.61 N/A

SLC27A1 ENST00000252595.7 solute carrier family 27 (fatty acid transporter), member 1 33 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A amyloid beta (A4) precursor protein-binding, family B, APBB1 ENST00000608655.1 64 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A member 1 (Fe65) SWI/SNF related, matrix associated, actin dependent SMARCB1 ENST00000344921.6 1293 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A regulator of chromatin, subfamily b, member 1 STMN3 ENST00000370053.1 stathmin-like 3 17 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

GNA14 ENST00000341700.6 guanine nucleotide binding protein (G protein), alpha 14 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

CEACAM21 ENST00000187608.9 carcinoembryonic antigen-related cell adhesion molecule 21 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A potassium voltage-gated channel, subfamily H (eag-related), KCNH6 ENST00000583023.1 5 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A member 6 ATAD3B ENST00000308647.7 ATPase family, AAA domain containing 3B 5 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

LAG3 ENST00000203629.2 lymphocyte-activation gene 3 32 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

STK17B ENST00000263955.4 serine/threonine kinase 17b 113 1 0 1 0 1 hsa-miR-5001-5p -0.19 -0.21 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score E2F6 ENST00000362009.4 E2F transcription factor 6 70 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.24 N/A microtubule associated monooxygenase, calponin and LIM MICAL3 ENST00000441493.2 58 2 0 1 1 0 hsa-miR-4498 -0.19 -0.2 N/A domain containing 3 CASP2 ENST00000310447.5 caspase 2, apoptosis-related cysteine peptidase 274 1 0 1 0 0 hsa-miR-4498 -0.19 -0.2 N/A tyrosine 3-monooxygenase/tryptophan 5-monooxygenase YWHAH ENST00000397492.1 7321 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A activation protein, eta polypeptide DAG1 ENST00000515359.2 dystroglycan 1 (dystrophin-associated glycoprotein 1) 241 2 1 1 0 0 hsa-miR-5001-5p -0.19 -0.22 N/A

FOXJ2 ENST00000162391.3 forkhead box J2 9 2 0 1 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CEND1 ENST00000330106.4 cell cycle exit and neuronal differentiation 1 28 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

CD209 ENST00000301357.8 CD209 molecule 5 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

POM121C ENST00000257665.5 POM121 transmembrane nucleoporin C 5 2 0 1 1 1 hsa-miR-4498 -0.19 -0.19 N/A

KCNK12 ENST00000327876.4 potassium channel, subfamily K, member 12 5 2 1 0 1 2 hsa-miR-5001-5p -0.19 -0.19 N/A

YPEL2 ENST00000312655.4 yippee-like 2 (Drosophila) 62 2 0 0 2 0 hsa-miR-5001-5p -0.19 -0.19 N/A

HTRA3 ENST00000307358.2 HtrA serine peptidase 3 5161 1 1 0 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CLDN22 ENST00000323319.5 claudin 22 5 1 1 0 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CHRNA7 ENST00000306901.3 cholinergic receptor, nicotinic, alpha 7 (neuronal) 5 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

COL5A1 ENST00000371817.3 collagen, type V, alpha 1 3111 2 0 2 0 0 hsa-miR-4498 -0.19 -0.19 N/A

MYO3A ENST00000265944.5 myosin IIIA 20 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

DUSP18 ENST00000403268.1 dual specificity phosphatase 18 491 1 0 1 0 2 hsa-miR-4498 -0.19 -0.21 N/A

AGPAT1 ENST00000395496.1 1-acylglycerol-3-phosphate O-acyltransferase 1 181 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

TSKU ENST00000333090.4 tsukushi, small leucine rich proteoglycan 293 5 0 5 0 3 hsa-miR-4498 -0.19 -0.73 N/A

WBSCR16 ENST00000329959.4 Williams-Beuren syndrome chromosome region 16 5 2 0 2 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CALML3 ENST00000315238.1 calmodulin-like 3 5 1 0 0 1 2 hsa-miR-5001-5p -0.19 -0.19 N/A

ZNF79 ENST00000342483.5 zinc finger protein 79 42 2 0 1 1 0 hsa-miR-5001-5p -0.19 -0.4 N/A

FAM83C ENST00000374408.3 family with sequence similarity 83, member C 5 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

AC011897.1 ENST00000581929.1 Uncharacterized protein 12 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

ANAPC2 ENST00000323927.2 anaphase promoting complex subunit 2 8 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PIGO ENST00000298004.5 phosphatidylinositol glycan anchor biosynthesis, class O 152 1 0 1 0 0 hsa-miR-4498 -0.19 -0.21 N/A

RASSF2 ENST00000379400.3 Ras association (RalGDS/AF-6) domain family member 2 88 2 0 1 1 1 hsa-miR-4498 -0.19 -0.19 N/A

ZNF333 ENST00000292530.6 zinc finger protein 333 72 1 0 1 0 2 hsa-miR-4498 -0.19 -0.26 N/A Bartter syndrome, infantile, with sensorineural deafness BSND ENST00000371265.4 5 2 1 1 0 6 hsa-miR-4498 -0.19 -0.28 N/A (Barttin) UDP-GlcNAc:betaGal beta-1,3-N- B3GNT3 ENST00000318683.6 5 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A acetylglucosaminyltransferase 3 CSRNP3 ENST00000314499.7 cysteine-serine-rich nuclear protein 3 24 2 0 1 1 1 hsa-miR-4498 -0.19 -0.19 N/A

WNT3 ENST00000225512.5 wingless-type MMTV integration site family, member 3 46 1 0 1 0 1 hsa-miR-5001-5p -0.19 -0.19 N/A

PITX3 ENST00000370002.3 paired-like homeodomain 3 8 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

KIAA0247 ENST00000342745.4 KIAA0247 161 1 0 1 0 3 hsa-miR-4498 -0.19 -0.19 N/A

CXCR3 ENST00000373691.4 chemokine (C-X-C motif) receptor 3 5 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

FAM3B ENST00000357985.2 family with sequence similarity 3, member B 34 1 0 0 1 1 hsa-miR-5001-5p -0.19 -0.36 N/A

NEURL ENST00000369780.4 neuralized homolog (Drosophila) 164 3 0 2 1 2 hsa-miR-5001-5p -0.19 -0.57 N/A

GATA5 ENST00000252997.2 GATA binding protein 5 7 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.25 N/A

AVPI1 ENST00000370626.3 arginine vasopressin-induced 1 4404 2 0 0 2 0 hsa-miR-4498 -0.19 -0.22 N/A

MAB21L3 ENST00000369500.3 mab-21-like 3 (C. elegans) 5 1 1 0 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

PPP1R1B ENST00000254079.4 protein phosphatase 1, regulatory (inhibitor) subunit 1B 5 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

RPRD1B ENST00000373433.4 regulation of nuclear pre-mRNA domain containing 1B 1140 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

HIRA ENST00000340170.4 histone cell cycle regulator 23 1 1 0 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A sulfotransferase family, cytosolic, 1A, phenol-preferring, SULT1A3 ENST00000395138.2 7 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A member 3 potassium inwardly-rectifying channel, subfamily J, member KCNJ10 ENST00000368089.3 5 2 0 0 2 0 hsa-miR-5001-5p -0.19 -0.19 N/A 10 ARHGAP9 ENST00000550288.1 Rho GTPase activating protein 9 29 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized PI4K2A ENST00000370649.3 1489 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A protein DGCR2 ENST00000545799.1 DiGeorge syndrome critical region gene 2 1754 3 0 2 1 1 hsa-miR-5001-5p -0.19 -0.19 N/A

SP4 ENST00000222584.3 Sp4 transcription factor 131 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

HKDC1 ENST00000354624.5 hexokinase domain containing 1 16 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CDNA FLJ27256 fis, clone SYN09689; Uncharacterized AC132872.2 ENST00000598222.1 24 1 0 1 0 0 hsa-miR-4498 -0.19 -0.24 N/A protein ZNF788 ENST00000430298.2 zinc finger family member 788 16 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CHST10 ENST00000264249.3 carbohydrate sulfotransferase 10 33 1 0 0 1 0 hsa-miR-4498 -0.19 -0.19 N/A

DUSP5 ENST00000369583.3 dual specificity phosphatase 5 600 1 0 1 0 0 hsa-miR-4498 -0.19 -0.19 N/A

ARHGAP42 ENST00000524892.2 Rho GTPase activating protein 42 36 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

FAM73A ENST00000370791.3 family with sequence similarity 73, member A 837 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

C9orf96 ENST00000371957.3 chromosome 9 open reading frame 96 5 1 1 0 0 1 hsa-miR-5001-5p -0.19 -0.19 N/A

CDC25A ENST00000302506.3 cell division cycle 25A 5 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

RAP1GAP ENST00000290101.4 RAP1 GTPase activating protein 396 1 0 1 0 1 hsa-miR-4498 -0.19 -0.19 N/A

C9orf16 ENST00000372994.1 chromosome 9 open reading frame 16 274 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

CEACAM8 ENST00000244336.5 carcinoembryonic antigen-related cell adhesion molecule 8 5 1 0 1 0 0 hsa-miR-5001-5p -0.19 -0.19 N/A

FLNB ENST00000357272.4 filamin B, beta 467 2 0 2 0 4 hsa-miR-5001-5p -0.19 -0.21 N/A

NIPSNAP1 ENST00000216121.7 nipsnap homolog 1 (C. elegans) 2429 1 0 0 1 0 hsa-miR-5001-5p -0.19 -0.19 N/A

POLR1A ENST00000263857.6 polymerase (RNA) I polypeptide A, 194kDa 675 6 2 4 0 2 hsa-miR-4498 -0.19 -0.44 N/A

SCNN1G ENST00000300061.2 sodium channel, non-voltage-gated 1, gamma subunit 5 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A

CRLF3 ENST00000324238.6 cytokine receptor-like factor 3 5 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

CSNK1G2 ENST00000255641.8 casein kinase 1, gamma 2 5 1 0 1 0 2 hsa-miR-4498 -0.18 -0.18 N/A

C9orf69 ENST00000561457.1 chromosome 9 open reading frame 69 134 1 0 1 0 3 hsa-miR-4498 -0.18 -0.22 N/A

CEP104 ENST00000378230.3 centrosomal protein 104kDa 73 2 1 1 0 1 hsa-miR-4498 -0.18 -0.47 N/A

PCSK5 ENST00000376752.4 proprotein convertase subtilisin/kexin type 5 68 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A transcription factor AP-2 alpha (activating enhancer binding TFAP2A ENST00000379613.3 367 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A protein 2 alpha) megalencephalic leukoencephalopathy with subcortical cysts MLC1 ENST00000395876.2 5 2 0 0 2 1 hsa-miR-5001-5p -0.18 -0.18 N/A 1 PRRX2 ENST00000372469.4 paired related homeobox 2 59 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

DRG2 ENST00000395726.4 developmentally regulated GTP binding protein 2 1552 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A potassium voltage-gated channel, KQT-like subfamily, KCNQ1 ENST00000155840.5 196 1 1 0 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A member 1 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CCDC163P ENST00000490551.3 coiled-coil domain containing 163, pseudogene 128 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.19 N/A

SEPHS2 ENST00000542752.1 selenophosphate synthetase 2 62 1 0 0 1 0 hsa-miR-4498 -0.18 -0.18 N/A

RABEPK ENST00000394124.4 Rab9 effector protein with kelch motifs 2485 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

APLNR ENST00000606794.1 apelin receptor 5 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A sulfotransferase family, cytosolic, 1A, phenol-preferring, SULT1A4 ENST00000344620.6 5 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A member 4 MBD1 ENST00000591416.1 methyl-CpG binding domain protein 1 266 1 0 1 0 3 hsa-miR-4498 -0.18 -0.22 N/A

STARD3 ENST00000336308.5 StAR-related lipid transfer (START) domain containing 3 35 1 0 1 0 0 hsa-miR-4498 -0.18 -0.24 N/A

UBAC1 ENST00000371756.3 UBA domain containing 1 52 1 0 1 0 2 hsa-miR-4498 -0.18 -0.29 N/A

GMPS ENST00000496455.2 guanine monphosphate synthase 867 1 0 1 0 0 hsa-miR-4498 -0.18 -0.2 N/A endoplasmic reticulum-golgi intermediate compartment ERGIC1 ENST00000393784.3 4614 1 0 1 0 2 hsa-miR-5001-5p -0.18 -0.24 N/A (ERGIC) 1 FOXJ3 ENST00000372571.1 forkhead box J3 329 1 0 1 0 1 hsa-miR-5001-5p -0.18 -0.19 N/A

ZNF3 ENST00000424697.1 zinc finger protein 3 671 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A

FAM84A ENST00000295092.2 family with sequence similarity 84, member A 69 1 0 1 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A

TMEM184A ENST00000297477.5 transmembrane protein 184A 28 2 0 2 0 3 hsa-miR-4498 -0.18 -0.26 N/A potassium voltage-gated channel, subfamily H (eag-related), KCNH2 ENST00000330883.4 165 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A member 2 SORD ENST00000267814.9 sorbitol dehydrogenase 5 1 1 0 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A

PRR19 ENST00000598490.1 proline rich 19 17 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A

PDE4C ENST00000355502.3 phosphodiesterase 4C, cAMP-specific 5 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

MKX ENST00000375790.5 mohawk homeobox 165 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

CCDC8 ENST00000307522.3 coiled-coil domain containing 8 68 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

FIBCD1 ENST00000448616.1 fibrinogen C domain containing 1 44 1 0 1 0 2 hsa-miR-5001-5p -0.18 -0.18 N/A

AGPAT6 ENST00000396987.3 1-acylglycerol-3-phosphate O-acyltransferase 6 474 2 0 2 0 1 hsa-miR-4498 -0.18 -0.4 N/A

POLR2E ENST00000215587.7 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 4066 3* 0 2 0 0 hsa-miR-4498 -0.18 -0.38 N/A

NLN ENST00000380985.5 neurolysin (metallopeptidase M3 family) 885 1 0 1 0 1 hsa-miR-4498 -0.18 -0.26 N/A

SVOP ENST00000299134.5 SV2 related protein homolog (rat) 8 2 0 2 0 3 hsa-miR-4498 -0.18 -0.32 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RAB3IL1 ENST00000394836.2 RAB3A interacting protein (rabin3)-like 1 157 1 0 1 0 2 hsa-miR-4498 -0.18 -0.18 N/A

HOXA13 ENST00000222753.4 homeobox A13 328 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

DHRS4 ENST00000558263.1 dehydrogenase/reductase (SDR family) member 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

VAT1 ENST00000355653.3 vesicle amine transport 1 2844 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A protein O-linked mannose N-acetylglucosaminyltransferase POMGNT1 ENST00000396420.3 2123 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A 1 (beta 1,2-) THAP8 ENST00000292894.1 THAP domain containing 8 86 2 0 2 0 1 hsa-miR-5001-5p -0.18 -0.28 N/A

NAV1 ENST00000295624.6 neuron navigator 1 702 2 0 2 0 0 hsa-miR-4498 -0.18 -0.18 N/A

LDLRAD4 ENST00000399848.3 low density lipoprotein receptor class A domain containing 4 314 1 1 0 0 1 hsa-miR-4498 -0.18 -0.49 N/A

TATDN2 ENST00000448281.2 TatD DNase domain containing 2 894 1 0 1 0 0 hsa-miR-4498 -0.18 -0.23 N/A

POU2AF1 ENST00000393067.3 POU class 2 associating factor 1 19 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A

ZNF584 ENST00000599238.1 zinc finger protein 584 282 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

ARRDC2 ENST00000379656.3 arrestin domain containing 2 144 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

KIF17 ENST00000375044.1 kinesin family member 17 5 1 0 1 0 2 hsa-miR-4498 -0.18 -0.18 N/A

PLLP ENST00000219207.5 plasmolipin 22 1 0 0 1 1 hsa-miR-4498 -0.18 -0.18 N/A

AL353791.1 ENST00000426179.1 5 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A

NDRG2 ENST00000298687.5 NDRG family member 2 217 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

EMX1 ENST00000258106.6 empty spiracles homeobox 1 35 3 0 2 1 0 hsa-miR-5001-5p -0.18 -0.39 N/A

C1QTNF4 ENST00000302514.3 C1q and tumor necrosis factor related protein 4 11 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.21 N/A

AP005482.1 ENST00000400514.2 Uncharacterized protein 44 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.28 N/A

FURIN ENST00000268171.3 furin (paired basic amino acid cleaving enzyme) 2306 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A ATPase, aminophospholipid transporter, class I, type 8B, ATP8B1 ENST00000283684.4 497 2 1 1 0 0 hsa-miR-4498 -0.18 -0.22 N/A member 1 AGO4 ENST00000373210.3 argonaute RISC catalytic component 4 96 1 1 0 0 0 hsa-miR-5001-5p -0.18 -0.2 N/A

SCUBE3 ENST00000274938.7 signal peptide, CUB domain, EGF-like 3 47 1 0 0 1 4 hsa-miR-5001-5p -0.18 -0.2 N/A

USP11 ENST00000377107.2 ubiquitin specific peptidase 11 1587 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A solute carrier family 37 (glucose-6-phosphate transporter), SLC37A1 ENST00000398341.3 12 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A member 1 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CIB2 ENST00000258930.3 calcium and integrin binding family member 2 119 1 0 1 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A

PSAPL1 ENST00000319098.4 prosaposin-like 1 (gene/pseudogene) 25 2 1 0 1 2 hsa-miR-5001-5p -0.18 -0.32 N/A

GPATCH8 ENST00000591680.1 G patch domain containing 8 337 1 0 0 1 1 hsa-miR-4498 -0.18 -0.26 N/A

IL17RD ENST00000296318.7 interleukin 17 receptor D 108 2 0 0 2 0 hsa-miR-5001-5p -0.18 -0.19 N/A

RGP1 ENST00000378078.4 RGP1 retrograde golgi transport homolog (S. cerevisiae) 203 3 2 0 1 1 hsa-miR-5001-5p -0.18 -0.47 N/A

MTHFSD ENST00000360900.6 methenyltetrahydrofolate synthetase domain containing 149 1 0 1 0 3 hsa-miR-4498 -0.18 -0.2 N/A

FOXO4 ENST00000374259.3 forkhead box O4 48 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A

TPI1 ENST00000229270.4 triosephosphate isomerase 1 4748 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

YPEL3 ENST00000566134.1 yippee-like 3 (Drosophila) 330 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A

NEUROD2 ENST00000302584.4 neuronal differentiation 2 5 1 0 1 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A potassium voltage-gated channel, shaker-related subfamily, KCNAB3 ENST00000303790.2 35 1 1 0 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A beta member 3 AXIN1 ENST00000262320.3 axin 1 27 1 1 0 0 0 hsa-miR-4498 -0.18 -0.18 N/A ubiquinol-cytochrome c reductase complex assembly factor UQCC1 ENST00000349714.5 500 2 0 2 0 0 hsa-miR-5001-5p -0.18 -0.31 N/A 1 solute carrier family 6 (neutral amino acid transporter), SLC6A19 ENST00000304460.10 139 1 0 1 0 3 hsa-miR-4498 -0.18 -0.23 N/A member 19 v-erb-b2 avian erythroblastic leukemia viral oncogene ERBB3 ENST00000267101.3 926 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A homolog 3 GRAP2 ENST00000344138.4 GRB2-related adaptor protein 2 5 4 0 0 4 0 hsa-miR-5001-5p -0.18 -0.4 N/A

FADS3 ENST00000540820.1 fatty acid desaturase 3 62 1 0 1 0 1 hsa-miR-4498 -0.18 -0.2 N/A

CMKLR1 ENST00000312143.7 chemokine-like receptor 1 5 2 0 1 1 2 hsa-miR-5001-5p -0.18 -0.18 N/A

HMBOX1 ENST00000397358.3 homeobox containing 1 27 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

WDR7 ENST00000254442.3 WD repeat domain 7 365 1 1 0 0 0 hsa-miR-4498 -0.18 -0.18 N/A

INPPL1 ENST00000298229.2 inositol polyphosphate phosphatase-like 1 1138 1 0 1 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A translational activator of mitochondrially encoded TACO1 ENST00000258975.6 755 2 0 1 1 1 hsa-miR-5001-5p -0.18 -0.44 N/A cytochrome c oxidase I SGSM1 ENST00000400358.4 small G protein signaling modulator 1 25 3 0 2 1 1 hsa-miR-4498 -0.18 -0.22 N/A

MAVS ENST00000428216.2 mitochondrial antiviral signaling protein 211 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A

NRARP ENST00000356628.2 NOTCH-regulated ankyrin repeat protein 56 1 0 1 0 4 hsa-miR-5001-5p -0.18 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ARHGEF10 ENST00000520359.1 Rho guanine nucleotide exchange factor (GEF) 10 326 1 0 1 0 0 hsa-miR-4498 -0.18 -0.2 N/A

FGD1 ENST00000375135.3 FYVE, RhoGEF and PH domain containing 1 138 1 0 1 0 0 hsa-miR-4498 -0.18 -0.22 N/A

KMT2D ENST00000301067.7 lysine (K)-specific methyltransferase 2D 78 1 0 1 0 3 hsa-miR-4498 -0.18 -0.18 N/A

PLK1 ENST00000300093.4 polo-like kinase 1 1127 1 0 1 0 0 hsa-miR-4498 -0.18 -0.18 N/A

TSC22D3 ENST00000372390.4 TSC22 domain family, member 3 154 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

SASH1 ENST00000367467.3 SAM and SH3 domain containing 1 79 1 0 0 1 0 hsa-miR-4498 -0.18 -0.18 N/A

PIK3IP1 ENST00000441972.1 phosphoinositide-3-kinase interacting protein 1 22 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A

TNIP2 ENST00000510267.1 TNFAIP3 interacting protein 2 920 1 0 1 0 0 hsa-miR-5001-5p -0.18 -0.18 N/A

ZNF764 ENST00000252797.2 zinc finger protein 764 59 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

EIF3L ENST00000412331.2 eukaryotic translation initiation factor 3, subunit L 113 1 0 1 0 0 hsa-miR-4498 -0.18 -0.24 N/A

C19orf66 ENST00000253110.11 chromosome 19 open reading frame 66 567 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.22 N/A

PTRF ENST00000357037.5 polymerase I and transcript release factor 987 2 0 1 1 4 hsa-miR-5001-5p -0.18 -0.18 N/A

DPH2 ENST00000255108.3 DPH2 homolog (S. cerevisiae) 209 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.23 N/A 28S ribosomal protein S17, mitochondrial; HCG1984214, MRPS17 ENST00000426595.1 81 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.21 N/A isoform CRA_a FAM169B ENST00000558256.1 family with sequence similarity 169, member B 5 1 0 1 0 1 hsa-miR-4498 -0.18 -0.18 N/A

CBL ENST00000264033.4 Cbl proto-oncogene, E3 ubiquitin protein ligase 309 3 0 2 1 0 hsa-miR-4498 -0.18 -0.18 N/A

C2orf43 ENST00000440866.2 chromosome 2 open reading frame 43 398 1 0 1 0 0 hsa-miR-4498 -0.18 -0.21 N/A

HOXB13 ENST00000290295.7 homeobox B13 80 1 0 0 1 0 hsa-miR-762 -0.18 -0.18 N/A

LOXL2 ENST00000389131.3 lysyl oxidase-like 2 701 2 1 1 0 2 hsa-miR-4498 -0.18 -0.42 N/A

KIAA1143 ENST00000296121.4 KIAA1143 5 1 0 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

ZFX ENST00000539115.1 zinc finger protein, X-linked 583 1 1 0 0 1 hsa-miR-5001-5p -0.18 -0.18 N/A

NEUROG1 ENST00000314744.4 neurogenin 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.18 -0.18 N/A

CELF3 ENST00000290585.4 CUGBP, Elav-like family member 3 5 1 0 1 0 1 hsa-miR-4498 -0.18 -0.19 N/A

RILPL1 ENST00000376874.4 Rab interacting lysosomal protein-like 1 155 2 0 0 2 0 hsa-miR-5001-5p -0.18 -0.4 N/A

SEC14L1 ENST00000413679.2 SEC14-like 1 (S. cerevisiae) 1399 2 1 1 0 2 hsa-miR-4498 -0.18 -0.19 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF155 ENST00000270014.2 zinc finger protein 155 13 1 1 0 0 1 hsa-miR-5001-5p -0.18 -0.51 N/A

ZC3HAV1 ENST00000242351.5 zinc finger CCCH-type, antiviral 1 45 2 1 0 1 0 hsa-miR-5001-5p -0.18 -0.18 N/A

CRCP ENST00000415001.2 CGRP receptor component 1776 2 0 1 1 1 hsa-miR-5001-5p -0.17 -0.74 N/A

FMO6P ENST00000236166.3 flavin containing monooxygenase 6 pseudogene 5 1 0 0 1 0 hsa-miR-4498 -0.17 -0.17 N/A

TMEM194A ENST00000379391.3 transmembrane protein 194A 43 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

TPM2 ENST00000378300.5 tropomyosin 2 (beta) 9695 1 0 1 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

SLC7A4 ENST00000403586.1 solute carrier family 7, member 4 5 1 0 0 1 0 hsa-miR-4498 -0.17 -0.17 N/A

OR2C3 ENST00000366487.3 olfactory receptor, family 2, subfamily C, member 3 5 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

TMEM40 ENST00000314124.7 transmembrane protein 40 5 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

TP53AIP1 ENST00000602346.1 tumor protein p53 regulated apoptosis inducing protein 1 5 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

DERL2 ENST00000572834.1 derlin 2 261 1 0 1 0 0 hsa-miR-4498 -0.17 -0.24 N/A

NUP62 ENST00000422090.2 nucleoporin 62kDa 3929 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

PCP4L1 ENST00000504449.1 Purkinje cell protein 4 like 1 23 1 0 1 0 0 hsa-miR-4498 -0.17 -0.23 N/A

PREB ENST00000260643.2 prolactin regulatory element binding 889 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.18 N/A

DOCK1 ENST00000280333.6 dedicator of cytokinesis 1 71 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

CARD6 ENST00000254691.5 caspase recruitment domain family, member 6 285 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

NHSL1 ENST00000427025.2 NHS-like 1 393 1 0 1 0 0 hsa-miR-762 -0.17 -0.17 N/A

DAPK2 ENST00000261891.3 death-associated protein kinase 2 21 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

FOXN1 ENST00000226247.2 forkhead box N1 5 2 0 0 2 0 hsa-miR-5001-5p -0.17 -0.17 N/A

MFSD10 ENST00000508221.1 major facilitator superfamily domain containing 10 5122 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

WDR1 ENST00000499869.2 WD repeat domain 1 8818 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.18 N/A

KANK2 ENST00000586659.1 KN motif and ankyrin repeat domains 2 1735 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A sema domain, seven thrombospondin repeats (type 1 and SEMA5B ENST00000195173.4 15 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A type 1-like), transmembrane domain (TM) and short IPO5 ENST00000261574.5 importin 5 1826 1 0 1 0 0 hsa-miR-4498 -0.17 -0.19 N/A

PAK3 ENST00000372007.5 p21 protein (Cdc42/Rac)-activated kinase 3 8 2 0 1 1 0 hsa-miR-5001-5p -0.17 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score WIPF2 ENST00000323571.4 WAS/WASL interacting protein family, member 2 214 3 0 2 1 1 hsa-miR-5001-5p -0.17 -0.33 N/A

SNED1 ENST00000310397.8 sushi, nidogen and EGF-like domains 1 19 2 1 0 1 0 hsa-miR-5001-5p -0.17 -0.2 N/A transient receptor potential cation channel, subfamily V, TRPV2 ENST00000338560.7 22341 2 0 1 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A member 2 PODXL ENST00000541194.1 podocalyxin-like 2928 1 0 1 0 0 hsa-miR-4498 -0.17 -0.18 N/A

MAP4K2 ENST00000294066.2 mitogen-activated protein kinase kinase kinase kinase 2 181 4 1 1 2 0 hsa-miR-762 -0.17 -0.32 N/A

KIAA1211L ENST00000397899.2 KIAA1211-like 7 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

POLR1D ENST00000399697.3 polymerase (RNA) I polypeptide D, 16kDa 2372 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

GAS7 ENST00000437099.2 growth arrest-specific 7 186 1 0 1 0 3 hsa-miR-4498 -0.17 -0.17 N/A

TNFSF9 ENST00000245817.3 tumor necrosis factor (ligand) superfamily, member 9 30 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

C10orf128 ENST00000374151.3 chromosome 10 open reading frame 128 0 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

C8orf17 ENST00000507535.3 chromosome 8 open reading frame 17 5 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

SPIN3 ENST00000374919.3 spindlin family, member 3 12 1 1 0 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

SFTPA2 ENST00000372325.2 surfactant protein A2 5 1 0 0 1 1 hsa-miR-4498 -0.17 -0.17 N/A

RGL3 ENST00000380456.3 ral guanine nucleotide dissociation stimulator-like 3 114 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

UNC5B ENST00000335350.6 unc-5 homolog B (C. elegans) 90 3 0 2 1 2 hsa-miR-5001-5p -0.17 -0.17 N/A

ICOS ENST00000435193.1 inducible T-cell co-stimulator 5 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

AMOTL1 ENST00000317837.9 angiomotin like 1 712 1 0 1 0 1 hsa-miR-4498 -0.17 -0.2 N/A

TBC1D30 ENST00000542120.1 TBC1 domain family, member 30 153 2 0 0 2 0 hsa-miR-5001-5p -0.17 -0.19 N/A

ZNF487 ENST00000437590.2 zinc finger protein 487 20 1 0 1 0 0 hsa-miR-4498 -0.17 -0.23 N/A

MGME1 ENST00000377710.5 mitochondrial genome maintenance exonuclease 1 41 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.2 N/A

ADRBK1 ENST00000308595.5 adrenergic, beta, receptor kinase 1 1312 2 0 1 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

ARHGAP35 ENST00000404338.3 Rho GTPase activating protein 35 278 4 0 2 2 4 hsa-miR-5001-5p -0.17 -0.18 N/A

ATP2A2 ENST00000395494.2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 2042 3 1 1 1 3 hsa-miR-5001-5p -0.17 -0.19 N/A

CPT1A ENST00000265641.5 carnitine palmitoyltransferase 1A (liver) 869 2 0 1 1 0 hsa-miR-4498 -0.17 -0.18 N/A

PVRL3 ENST00000319792.3 poliovirus receptor-related 3 361 1 0 1 0 0 hsa-miR-4498 -0.17 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GIPC1 ENST00000393029.3 GIPC PDZ domain containing family, member 1 2934 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A transient receptor potential cation channel, subfamily V, TRPV4 ENST00000418703.2 80 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A member 4 HCG1777807; Leucine zipper protein 3; Uncharacterized LUZPP1 ENST00000599511.1 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A protein CNTN6 ENST00000446702.2 contactin 6 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A solute carrier family 12 (potassium/chloride transporter), SLC12A5 ENST00000243964.3 5 2 0 2 0 0 hsa-miR-4498 -0.17 -0.17 N/A member 5 SECTM1 ENST00000269389.3 secreted and transmembrane 1 30 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

TMEM132B ENST00000299308.3 transmembrane protein 132B 5 3 0 2 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

CLK3 ENST00000348245.3 CDC-like kinase 3 127 1 0 1 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

GPR3 ENST00000374024.3 G protein-coupled receptor 3 5 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A tumor necrosis factor receptor superfamily, member 11a, TNFRSF11A ENST00000586569.1 93 3 0 2 1 1 hsa-miR-4498 -0.17 -0.36 N/A NFKB activator CNNM2 ENST00000369878.4 cyclin M2 517 3 0 3 0 0 hsa-miR-4498 -0.17 -0.31 N/A

PTCD2 ENST00000380639.5 pentatricopeptide repeat domain 2 377 2 0 0 2 1 hsa-miR-5001-5p -0.17 -0.3 N/A

PGK1 ENST00000373316.4 phosphoglycerate kinase 1 7680 1 1 0 0 1 hsa-miR-5001-5p -0.17 -0.4 N/A

TEX261 ENST00000272438.4 testis expressed 261 359 1 0 1 0 0 hsa-miR-4498 -0.17 -0.23 N/A

RBL1 ENST00000373664.3 retinoblastoma-like 1 (p107) 88 1 0 1 0 0 hsa-miR-4498 -0.17 -0.27 N/A

ADAP1 ENST00000265846.5 ArfGAP with dual PH domains 1 328 4 1 1 2 6 hsa-miR-5001-5p -0.17 -0.47 N/A

FARSA ENST00000588025.1 phenylalanyl-tRNA synthetase, alpha subunit 1994 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

LRRC25 ENST00000339007.3 leucine rich repeat containing 25 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

NTRK3 ENST00000394480.2 neurotrophic tyrosine kinase, receptor, type 3 7 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

RTBDN ENST00000589272.1 retbindin 5 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

SNX15 ENST00000377244.3 sorting nexin 15 341 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

MTNR1B ENST00000257068.2 melatonin receptor 1B 5 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

FRMD4A ENST00000358621.4 FERM domain containing 4A 192 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

HAS1 ENST00000601714.1 hyaluronan synthase 1 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

IL36RN ENST00000346807.3 interleukin 36 receptor antagonist 5 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CLOCK ENST00000309964.4 clock circadian regulator 86 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

HN1L ENST00000248098.3 hematological and neurological expressed 1-like 1302 1 0 1 0 1 hsa-miR-4498 -0.17 -0.18 N/A

FAM196B ENST00000377365.3 family with sequence similarity 196, member B 174 1 0 1 0 0 hsa-miR-4498 -0.17 -0.18 N/A

HPCAL1 ENST00000381765.3 hippocalcin-like 1 233 1 0 1 0 2 hsa-miR-4498 -0.17 -0.17 N/A

TTLL11 ENST00000373776.3 tubulin tyrosine ligase-like family, member 11 164 1 0 1 0 0 hsa-miR-4498 -0.17 -0.18 N/A

AP3S2 ENST00000336418.4 adaptor-related protein complex 3, sigma 2 subunit 985 2 0 1 1 1 hsa-miR-5001-5p -0.17 -0.32 N/A

FOXL1 ENST00000320241.3 forkhead box L1 367 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A Homo sapiens ribonuclease, RNase A family, 4 (RNASE4), AL163636.6 ENST00000553909.1 103 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A transcript variant 4, mRNA. DNAJB2 ENST00000336576.5 DnaJ (Hsp40) homolog, subfamily B, member 2 2187 2 1 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

PTCD1 ENST00000292478.4 pentatricopeptide repeat domain 1 22 4 2 2 0 0 hsa-miR-4498 -0.17 -0.99 N/A

HOXD3 ENST00000249440.3 homeobox D3 23 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.22 N/A

TPGS1 ENST00000359315.5 tubulin polyglutamylase complex subunit 1 81 5 0 3 2 1 hsa-miR-4498 -0.17 -0.47 N/A

CLCN4 ENST00000380833.4 chloride channel, voltage-sensitive 4 182 1 1 0 0 0 hsa-miR-5001-5p -0.17 -0.21 N/A

ARFRP1 ENST00000440854.1 ADP-ribosylation factor related protein 1 652 2 0 2 0 3 hsa-miR-4498 -0.17 -0.19 N/A solute carrier family 6 (proline IMINO transporter), member SLC6A20 ENST00000353278.4 5 2 0 1 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A 20 ARHGAP19- ENST00000453547.2 ARHGAP19-SLIT1 readthrough (NMD candidate) 15 2 1 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A SLIT1 ZNF263 ENST00000219069.5 zinc finger protein 263 593 1 0 0 1 0 hsa-miR-4498 -0.17 -0.17 N/A

ABHD2 ENST00000352732.5 abhydrolase domain containing 2 210 2 0 1 1 3 hsa-miR-4498 -0.17 -0.19 N/A

RTN4RL1 ENST00000331238.6 reticulon 4 receptor-like 1 82 1 0 1 0 2 hsa-miR-5001-5p -0.17 -0.17 N/A

CMTM4 ENST00000394106.2 CKLF-like MARVEL transmembrane domain containing 4 22 3 2 1 0 1 hsa-miR-5001-5p -0.17 -0.63 N/A

C1orf226 ENST00000458626.2 chromosome 1 open reading frame 226 369 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A solute carrier family 16 (monocarboxylate transporter), SLC16A3 ENST00000581287.1 16333 3 0 2 1 6 hsa-miR-4498 -0.17 -0.4 N/A member 3 CNOT4 ENST00000541284.1 CCR4-NOT transcription complex, subunit 4 27 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

MOB3B ENST00000262244.5 MOB kinase activator 3B 52 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

RSPH3 ENST00000367069.2 radial spoke 3 homolog (Chlamydomonas) 59 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CTD (carboxy-terminal domain, RNA polymerase II, CTDP1 ENST00000075430.7 63 1 0 1 0 0 hsa-miR-762 -0.17 -0.17 N/A polypeptide A) phosphatase, subunit 1 DBN1 ENST00000512501.1 drebrin 1 9937 1 0 1 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

CASC10 ENST00000377113.5 cancer susceptibility candidate 10 116 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

PLB1 ENST00000422425.2 phospholipase B1 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

CCDC120 ENST00000376396.3 coiled-coil domain containing 120 170 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

MAB21L1 ENST00000379919.4 mab-21-like 1 (C. elegans) 25 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

ULK3 ENST00000440863.2 unc-51 like kinase 3 22 1 0 0 1 3 hsa-miR-5001-5p -0.17 -0.17 N/A

MTA1 ENST00000331320.7 metastasis associated 1 8 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A 5-hydroxytryptamine (serotonin) receptor 6, G protein- HTR6 ENST00000289753.1 16 2 0 2 0 2 hsa-miR-4498 -0.17 -0.26 N/A coupled SKI ENST00000378536.4 v-ski avian sarcoma viral oncogene homolog 613 2 0 0 2 2 hsa-miR-5001-5p -0.17 -0.19 N/A

RABL3 ENST00000273375.3 RAB, member of RAS oncogene family-like 3 165 1 0 1 0 0 hsa-miR-4498 -0.17 -0.33 N/A

ZNF195 ENST00000438262.2 zinc finger protein 195 389 1 0 0 1 0 hsa-miR-4498 -0.17 -0.17 N/A

SLC22A15 ENST00000369503.4 solute carrier family 22, member 15 25 2 0 0 2 1 hsa-miR-5001-5p -0.17 -0.22 N/A

WDR92 ENST00000295121.6 WD repeat domain 92 132 2 0 2 0 0 hsa-miR-4498 -0.17 -0.54 N/A

FRAT2 ENST00000371019.2 frequently rearranged in advanced T-cell lymphomas 2 120 1 0 1 0 0 hsa-miR-4498 -0.17 -0.3 N/A

SNX8 ENST00000222990.3 sorting nexin 8 303 2 0 1 1 2 hsa-miR-4498 -0.17 -0.18 N/A

CHDH ENST00000315251.6 choline dehydrogenase 249 2 0 1 1 2 hsa-miR-4498 -0.17 -0.47 N/A

ZFP2 ENST00000361362.2 ZFP2 zinc finger protein 9 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

GRM1 ENST00000392299.2 glutamate receptor, metabotropic 1 5 2 0 1 1 0 hsa-miR-4498 -0.17 -0.17 N/A

FAM211B ENST00000318753.8 family with sequence similarity 211, member B 173 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

SOD3 ENST00000382120.3 superoxide dismutase 3, extracellular 5 1 0 1 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

NXF1 ENST00000531709.2 nuclear RNA export factor 1 1017 2 0 1 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

PUM1 ENST00000424085.2 pumilio RNA-binding family member 1 202 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A

PCDHB17 ENST00000539533.1 Protocadherin-psi1; Uncharacterized protein 5 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

CRY2 ENST00000443527.2 cryptochrome 2 (photolyase-like) 63 1 0 1 0 2 hsa-miR-4498 -0.17 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AC008132.1 ENST00000342888.3 Uncharacterized protein 5 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

PTPRD ENST00000381196.4 protein tyrosine phosphatase, receptor type, D 101 1 1 0 0 0 hsa-miR-5001-5p -0.17 -0.36 N/A

PRKCI ENST00000295797.4 protein kinase C, iota 103 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A solute carrier family 7 (cationic amino acid transporter, y+ SLC7A1 ENST00000380752.5 338 2 2 0 0 4 hsa-miR-5001-5p -0.17 -0.18 N/A system), member 1 solute carrier family 28 (concentrative nucleoside SLC28A3 ENST00000376238.4 14 1 0 1 0 0 hsa-miR-4498 -0.17 -0.17 N/A transporter), member 3 CASP9 ENST00000546424.1 caspase 9, apoptosis-related cysteine peptidase 390 3 0 2 1 0 hsa-miR-4498 -0.17 -0.42 N/A

KIF24 ENST00000402558.2 kinesin family member 24 84 2 0 2 0 1 hsa-miR-4498 -0.17 -0.17 N/A

CCDC3 ENST00000378825.3 coiled-coil domain containing 3 16 1 0 0 1 1 hsa-miR-5001-5p -0.17 -0.17 N/A

LYPD3 ENST00000244333.3 LY6/PLAUR domain containing 3 13 1 0 1 0 0 hsa-miR-5001-5p -0.17 -0.17 N/A

RIBC1 ENST00000414955.2 RIB43A domain with coiled-coils 1 15 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.26 N/A

PQLC1 ENST00000590381.1 PQ loop repeat containing 1 1060 4 0 2 2 2 hsa-miR-5001-5p -0.17 -0.53 N/A

RXRA ENST00000481739.1 retinoid X receptor, alpha 609 3 0 2 1 1 hsa-miR-4498 -0.17 -0.39 N/A

MAPK4 ENST00000592595.1 mitogen-activated protein kinase 4 77 2 0 2 0 3 hsa-miR-4498 -0.17 -0.18 N/A NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa NDUFS7 ENST00000313408.7 3661 1 0 1 0 2 hsa-miR-5001-5p -0.17 -0.17 N/A (NADH-coenzyme Q reductase) SAE1 ENST00000392776.3 SUMO1 activating enzyme subunit 1 87 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

TWIST2 ENST00000448943.2 twist basic helix-loop-helix transcription factor 2 5 1 0 0 1 0 hsa-miR-4498 -0.17 -0.17 N/A

ZNF736 ENST00000423484.2 zinc finger protein 736 36 2 2 0 0 1 hsa-miR-5001-5p -0.17 -0.17 N/A

TESC ENST00000335209.7 tescalcin 22 1 0 0 1 0 hsa-miR-5001-5p -0.17 -0.17 N/A

PPL ENST00000345988.2 periplakin 849 1 0 1 0 2 hsa-miR-4498 -0.17 -0.17 N/A

RNF222 ENST00000344001.3 ring finger protein 222 5 1 0 1 0 1 hsa-miR-4498 -0.17 -0.17 N/A

FYCO1 ENST00000296137.2 FYVE and coiled-coil domain containing 1 91 2 0 0 2 2 hsa-miR-4498 -0.16 -0.17 N/A

MRGPRF ENST00000441623.1 MAS-related GPR, member F 140 5 0 3 2 4 hsa-miR-4498 -0.16 -0.71 N/A

TMEM255A ENST00000309720.5 transmembrane protein 255A 113 1 1 0 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

ETV3 ENST00000368192.4 ets variant 3 37 2 0 0 2 0 hsa-miR-5001-5p -0.16 -0.16 N/A

GPR123 ENST00000607359.1 G protein-coupled receptor 123 5 1 0 1 0 2 hsa-miR-4498 -0.16 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FAM65B ENST00000259698.4 family with sequence similarity 65, member B 7 1 1 0 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

TPRN ENST00000409012.4 taperin 1586 1 0 0 1 0 hsa-miR-4498 -0.16 -0.16 N/A

RBM22 ENST00000199814.4 RNA binding motif protein 22 4854 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.17 N/A

IL19 ENST00000340758.2 interleukin 19 5 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

PHF2 ENST00000375376.4 PHD finger protein 2 151 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

PPP1R12B ENST00000608999.1 protein phosphatase 1, regulatory subunit 12B 18 3 0 2 1 4 hsa-miR-5001-5p -0.16 -0.26 N/A

PBX2 ENST00000375050.4 pre-B-cell leukemia homeobox 2 98 1 0 1 0 1 hsa-miR-4498 -0.16 -0.17 N/A

CLSTN2 ENST00000458420.3 calsyntenin 2 119 5 0 2 3 2 hsa-miR-5001-5p -0.16 -0.29 N/A excision repair cross-complementing rodent repair ERCC2 ENST00000391945.4 2075 2 1 0 1 0 hsa-miR-5001-5p -0.16 -0.47 N/A deficiency, complementation group 2 FAM109B ENST00000321753.3 family with sequence similarity 109, member B 78 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

CCDC106 ENST00000308964.3 coiled-coil domain containing 106 21 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

C2CD2L ENST00000336702.3 C2CD2-like 13 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

HMOX1 ENST00000216117.8 heme oxygenase (decycling) 1 702 1 0 1 0 1 hsa-miR-4498 -0.16 -0.16 N/A

FLCN ENST00000285071.4 folliculin 349 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

PRRG2 ENST00000246794.5 proline rich Gla (G-carboxyglutamic acid) 2 8 1 0 1 0 1 hsa-miR-5001-5p -0.16 -0.16 N/A

ZNF891 ENST00000537226.1 zinc finger protein 891 9 1 0 1 0 0 hsa-miR-4498 -0.16 -0.23 N/A

PMEPA1 ENST00000341744.3 prostate transmembrane protein, androgen induced 1 736 1 0 0 1 2 hsa-miR-5001-5p -0.16 -0.28 N/A collagen-like tail subunit (single strand of homotrimer) of COLQ ENST00000383785.2 8 1 1 0 0 2 hsa-miR-5001-5p -0.16 -0.16 N/A asymmetric acetylcholinesterase SLC26A1 ENST00000361661.2 solute carrier family 26 (anion exchanger), member 1 241 1 0 1 0 3 hsa-miR-4498 -0.16 -0.17 N/A

PURB ENST00000395699.2 purine-rich element binding protein B 497 2 1 1 0 0 hsa-miR-5001-5p -0.16 -0.38 N/A

KPNA5 ENST00000368564.1 karyopherin alpha 5 (importin alpha 6) 76 1 0 1 0 0 hsa-miR-4498 -0.16 -0.18 N/A

BAZ1B ENST00000339594.4 bromodomain adjacent to zinc finger domain, 1B 40 2 1 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

CYP26B1 ENST00000001146.2 cytochrome P450, family 26, subfamily B, polypeptide 1 1315 2 1 1 0 2 hsa-miR-5001-5p -0.16 -0.16 N/A

HIST1H2BF ENST00000359985.1 histone cluster 1, H2bf 16 2 0 2 0 0 hsa-miR-4498 -0.16 -0.24 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS15 ENST00000299164.2 18 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.16 N/A 15 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TPP1 ENST00000299427.6 tripeptidyl peptidase I 713 1 0 1 0 0 hsa-miR-4498 -0.16 -0.2 N/A

BLOC1S3 ENST00000433642.2 biogenesis of lysosomal organelles complex-1, subunit 3 182 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

PER3 ENST00000377532.3 period circadian clock 3 16 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

PEX19 ENST00000368072.5 peroxisomal biogenesis factor 19 1804 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

DDX51 ENST00000397333.3 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 90 2 1 0 1 1 hsa-miR-5001-5p -0.16 -0.35 N/A

CNGB1 ENST00000564448.1 cyclic nucleotide gated channel beta 1 5 1 0 1 0 2 hsa-miR-5001-5p -0.16 -0.23 N/A glucosaminyl (N-acetyl) transferase 2, I-branching enzyme GCNT2 ENST00000316170.3 651 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A (I blood group) PCNT ENST00000359568.5 pericentrin 92 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

ZSCAN1 ENST00000282326.1 zinc finger and SCAN domain containing 1 5 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

ZNF777 ENST00000247930.4 zinc finger protein 777 122 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

SYT10 ENST00000228567.3 synaptotagmin X 5 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

LARGE ENST00000354992.2 like-glycosyltransferase 411 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

TCHH ENST00000368804.1 trichohyalin 7 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

SOWAHA ENST00000378693.2 sosondowah ankyrin repeat domain family member A 138 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

GLI2 ENST00000452319.1 GLI family zinc finger 2 73 2 0 0 2 1 hsa-miR-5001-5p -0.16 -0.16 N/A

KIAA1033 ENST00000332180.5 KIAA1033 238 1 1 0 0 0 hsa-miR-5001-5p -0.16 -0.23 N/A

NXN ENST00000575801.1 nucleoredoxin 811 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.18 N/A

GNB5 ENST00000261837.7 guanine nucleotide binding protein (G protein), beta 5 513 1 1 0 0 0 hsa-miR-4498 -0.16 -0.25 N/A

MTHFR ENST00000376592.1 methylenetetrahydrofolate reductase (NAD(P)H) 207 3 0 2 1 3 hsa-miR-5001-5p -0.16 -0.57 N/A

FAM172A ENST00000395965.3 family with sequence similarity 172, member A 257 2 0 1 1 0 hsa-miR-4498 -0.16 -0.17 N/A

SPATA2 ENST00000289431.5 spermatogenesis associated 2 358 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.18 N/A

HCG27 ENST00000383331.4 HLA complex group 27 (non-protein coding) 5 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.16 N/A

DHRS4L2 ENST00000335125.6 dehydrogenase/reductase (SDR family) member 4 like 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

SLC52A2 ENST00000526752.1 solute carrier family 52 (riboflavin transporter), member 2 483 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

LNX2 ENST00000316334.3 ligand of numb-protein X 2 760 1 0 0 1 0 hsa-miR-4498 -0.16 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score BIRC3 ENST00000532808.1 baculoviral IAP repeat containing 3 9 1 0 1 0 1 hsa-miR-5001-5p -0.16 -0.16 N/A

PNPLA3 ENST00000216180.3 patatin-like phospholipase domain containing 3 147 3 0 3 0 1 hsa-miR-4498 -0.16 -0.18 N/A

SCN1A ENST00000423058.2 sodium channel, voltage-gated, type I, alpha subunit 21 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

ASCC1 ENST00000342444.4 activating signal cointegrator 1 complex subunit 1 293 1 0 1 0 2 hsa-miR-4498 -0.16 -0.2 N/A serum response factor (c-fos serum response element- SRF ENST00000265354.4 596 1 0 1 0 1 hsa-miR-5001-5p -0.16 -0.17 N/A binding transcription factor) CSNK1A1 ENST00000261798.5 casein kinase 1, alpha 1 769 2 0 1 1 0 hsa-miR-4498 -0.16 -0.27 N/A

MYBPC3 ENST00000545968.1 myosin binding protein C, cardiac 5 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

ANKFY1 ENST00000341657.4 ankyrin repeat and FYVE domain containing 1 969 2 0 2 0 1 hsa-miR-4498 -0.16 -0.16 N/A

LMOD1 ENST00000367288.4 leiomodin 1 (smooth muscle) 148 2 0 2 0 1 hsa-miR-4498 -0.16 -0.28 N/A

NIPAL3 ENST00000003912.3 NIPA-like domain containing 3 775 2 0 1 1 0 hsa-miR-4498 -0.16 -0.2 N/A

LIF ENST00000403987.3 leukemia inhibitory factor 55 1 0 1 0 0 hsa-miR-4498 -0.16 -0.18 N/A

FZR1 ENST00000441788.2 fizzy/cell division cycle 20 related 1 (Drosophila) 273 2 0 1 1 1 hsa-miR-4498 -0.16 -0.22 N/A

PCDH17 ENST00000377918.3 protocadherin 17 477 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

FAT3 ENST00000298047.6 FAT atypical cadherin 3 30 1 1 0 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

OTP ENST00000306422.3 orthopedia homeobox 9 2 0 1 1 1 hsa-miR-5001-5p -0.16 -0.16 N/A

JMJD7 ENST00000397299.4 jumonji domain containing 7 311 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

IER3 ENST00000376377.2 immediate early response 3 768 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

TP63 ENST00000392460.3 tumor protein p63 0 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

C19orf24 ENST00000409293.4 chromosome 19 open reading frame 24 3071 3 0 1 2 1 hsa-miR-5001-5p -0.16 -0.55 N/A

LURAP1 ENST00000371980.3 leucine rich adaptor protein 1 20 1 0 1 0 0 hsa-miR-4498 -0.16 -0.2 N/A

CDK6 ENST00000265734.4 cyclin-dependent kinase 6 1116 1 1 0 0 1 hsa-miR-5001-5p -0.16 -0.18 N/A

SUPT6H ENST00000314616.6 suppressor of Ty 6 homolog (S. cerevisiae) 405 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.27 N/A

VAV3 ENST00000370056.4 vav 3 guanine nucleotide exchange factor 1128 2 0 1 1 1 hsa-miR-4498 -0.16 -0.18 N/A

ESRRG ENST00000361525.3 estrogen-related receptor gamma 5 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

C16orf71 ENST00000299320.5 chromosome 16 open reading frame 71 5 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SZRD1 ENST00000401089.3 SUZ RNA binding domain containing 1 137 2 0 1 1 1 hsa-miR-4498 -0.16 -0.51 N/A

SGMS2 ENST00000394684.4 sphingomyelin synthase 2 111 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

GSC ENST00000238558.3 goosecoid homeobox 5 1 0 0 1 1 hsa-miR-4492 -0.16 -0.16 N/A amyloid beta (A4) precursor protein-binding, family A, APBA2 ENST00000558402.1 388 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A member 2 POLM ENST00000335195.6 polymerase (DNA directed), mu 45 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

RUNDC3A ENST00000426726.3 RUN domain containing 3A 11 1 0 1 0 1 hsa-miR-4498 -0.16 -0.16 N/A

KIAA1549 ENST00000440172.1 KIAA1549 508 2 1 1 0 0 hsa-miR-5001-5p -0.16 -0.18 N/A

SCG5 ENST00000300175.4 secretogranin V (7B2 protein) 153 1 0 1 0 0 hsa-miR-4498 -0.16 -0.35 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ1 ENST00000392665.2 9 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A 1 NUAK2 ENST00000367157.3 NUAK family, SNF1-like kinase, 2 213 1 0 1 0 1 hsa-miR-4498 -0.16 -0.16 N/A

AP5B1 ENST00000532090.2 adaptor-related protein complex 5, beta 1 subunit 22 2 0 2 0 1 hsa-miR-5001-5p -0.16 -0.38 N/A

STX1A ENST00000395156.3 syntaxin 1A (brain) 82 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

IRX2 ENST00000382611.6 iroquois homeobox 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.16 N/A

SERTAD2 ENST00000313349.3 SERTA domain containing 2 119 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.2 N/A solute carrier family 22 (organic cation/carnitine SLC22A5 ENST00000245407.3 37 1 0 1 0 0 hsa-miR-4498 -0.16 -0.23 N/A transporter), member 5 IL12RB2 ENST00000262345.1 interleukin 12 receptor, beta 2 5 3 1 1 1 0 hsa-miR-4498 -0.16 -0.42 N/A

HAUS2 ENST00000260372.3 HAUS augmin-like complex, subunit 2 270 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.17 N/A

PFAS ENST00000314666.6 phosphoribosylformylglycinamidine synthase 901 1 0 0 1 2 hsa-miR-4498 -0.16 -0.16 N/A

CDK17 ENST00000543119.2 cyclin-dependent kinase 17 475 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

PTPN11 ENST00000351677.2 protein tyrosine phosphatase, non-receptor type 11 52 1 0 1 0 2 hsa-miR-4498 -0.16 -0.16 N/A

NOP14 ENST00000416614.2 NOP14 nucleolar protein 1237 1 0 0 1 0 hsa-miR-4498 -0.16 -0.16 N/A

GOLGA7 ENST00000405786.2 golgin A7 34 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.19 N/A

PITPNM1 ENST00000534749.1 phosphatidylinositol transfer protein, membrane-associated 1 39 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

ANKRD65 ENST00000520296.1 ankyrin repeat domain 65 5 1 0 1 0 1 hsa-miR-5001-5p -0.16 -0.16 N/A

ZNF212 ENST00000335870.2 zinc finger protein 212 7 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MAD2L2 ENST00000235310.3 MAD2 mitotic arrest deficient-like 2 (yeast) 1408 1 0 1 0 0 hsa-miR-4498 -0.16 -0.16 N/A

RNF185 ENST00000326132.6 ring finger protein 185 97 1 0 0 1 1 hsa-miR-5001-5p -0.16 -0.16 N/A

ALPPL2 ENST00000295453.3 alkaline phosphatase, placental-like 2 5 1 0 1 0 0 hsa-miR-5001-5p -0.16 -0.16 N/A

CCDC144A ENST00000443444.2 coiled-coil domain containing 144A 5 3 1 0 2 1 hsa-miR-5001-5p -0.16 -0.16 N/A

EYA3 ENST00000373871.3 eyes absent homolog 3 (Drosophila) 50 1 1 0 0 2 hsa-miR-5001-5p -0.16 -0.16 N/A

C17orf70 ENST00000327787.8 chromosome 17 open reading frame 70 329 1 0 1 0 3 hsa-miR-5001-5p -0.16 -0.16 N/A

TXNRD2 ENST00000535882.1 thioredoxin reductase 2 148 1 1 0 0 2 hsa-miR-5001-5p -0.16 -0.16 N/A

CD6 ENST00000313421.7 CD6 molecule 5 1 0 1 0 3 hsa-miR-4498 -0.16 -0.16 N/A

PRUNE2 ENST00000376718.3 prune homolog 2 (Drosophila) 121 2 0 0 2 1 hsa-miR-5001-5p -0.16 -0.21 N/A

NAGA ENST00000396398.3 N-acetylgalactosaminidase, alpha- 841 1 0 0 1 1 hsa-miR-4498 -0.16 -0.2 N/A

C9orf91 ENST00000374049.4 chromosome 9 open reading frame 91 151 2 0 2 0 0 hsa-miR-4498 -0.16 -0.28 N/A

AURKB ENST00000535053.1 aurora kinase B 57 1 0 0 1 0 hsa-miR-5001-5p -0.16 -0.18 N/A

TSHZ2 ENST00000371497.5 teashirt zinc finger homeobox 2 351 2 0 1 1 0 hsa-miR-4498 -0.16 -0.16 N/A

MYO1A ENST00000300119.3 myosin IA 106 3 0 2 1 1 hsa-miR-4498 -0.16 -0.37 N/A

APOA5 ENST00000227665.4 apolipoprotein A-V 14 1 0 1 0 0 hsa-miR-4498 -0.16 -0.28 N/A

EMC10 ENST00000376918.3 ER membrane protein complex subunit 10 1981 2 0 2 0 4 hsa-miR-4498 -0.16 -0.35 N/A

CACNG8 ENST00000270458.2 calcium channel, voltage-dependent, gamma subunit 8 5 1 1 0 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A

KIAA0556 ENST00000261588.4 KIAA0556 169 1 0 1 0 2 hsa-miR-5001-5p -0.15 -0.15 N/A

KIF19 ENST00000389916.4 kinesin family member 19 5 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A

KLF17 ENST00000372299.3 Kruppel-like factor 17 11 1 1 0 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

HLA-B ENST00000412585.2 major histocompatibility complex, class I, B 344 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

NFASC ENST00000401399.1 neurofascin 10 4 0 2 2 3 hsa-miR-5001-5p -0.15 -0.15 N/A

KIAA1324 ENST00000369939.3 KIAA1324 41 1 0 0 1 1 hsa-miR-4498 -0.15 -0.27 N/A

CCL11 ENST00000305869.3 chemokine (C-C motif) ligand 11 12 1 0 1 0 0 hsa-miR-4498 -0.15 -0.39 N/A harakiri, BCL2 interacting protein (contains only BH3 HRK ENST00000257572.5 19 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A domain) Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score HIATL1 ENST00000428393.2 hippocampus abundant transcript-like 1 767 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.16 N/A

TPRG1L ENST00000378344.2 tumor protein p63 regulated 1-like 203 1 0 1 0 0 hsa-miR-4498 -0.15 -0.2 N/A

ANKRD52 ENST00000267116.7 ankyrin repeat domain 52 2913 3 0 1 2 7 hsa-miR-5001-5p -0.15 -0.15 N/A

CD3EAP ENST00000309424.3 CD3e molecule, epsilon associated protein 213 1 0 1 0 0 hsa-miR-4498 -0.15 -0.25 N/A

DPP6 ENST00000404039.1 dipeptidyl-peptidase 6 5 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

UNC5A ENST00000261961.3 unc-5 homolog A (C. elegans) 7 1 1 0 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

TAB2 ENST00000367456.1 TGF-beta activated kinase 1/MAP3K7 binding protein 2 1129 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A potassium large conductance calcium-activated channel, KCNMB1 ENST00000274629.4 5 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A subfamily M, beta member 1 peptidase domain containing associated with muscle PAMR1 ENST00000278360.3 40 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A regeneration 1 HAS3 ENST00000306560.1 hyaluronan synthase 3 15 1 1 0 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

SCNN1D ENST00000400928.3 sodium channel, non-voltage-gated 1, delta subunit 114 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

RPS6KA4 ENST00000528057.1 ribosomal protein S6 kinase, 90kDa, polypeptide 4 1763 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

TP53INP2 ENST00000374810.3 tumor protein p53 inducible nuclear protein 2 12 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A

USP40 ENST00000450966.1 ubiquitin specific peptidase 40 74 1 0 1 0 2 hsa-miR-5001-5p -0.15 -0.18 N/A

ACOX3 ENST00000356406.5 acyl-CoA oxidase 3, pristanoyl 551 2 0 0 2 0 hsa-miR-5001-5p -0.15 -0.33 N/A

LSS ENST00000397728.3 lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 564 2 1 0 1 0 hsa-miR-5001-5p -0.15 -0.16 N/A

GRIN2A ENST00000562109.1 glutamate receptor, ionotropic, N-methyl D-aspartate 2A 5 2 0 0 2 0 hsa-miR-5001-5p -0.15 -0.2 N/A

COL6A2 ENST00000300527.4 collagen, type VI, alpha 2 9107 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

TBX5 ENST00000349716.5 T-box 5 68 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.22 N/A

PCYOX1L ENST00000274569.4 prenylcysteine oxidase 1 like 546 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

ELF5 ENST00000257832.2 E74-like factor 5 (ets domain transcription factor) 5 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

TTC9 ENST00000256367.2 tetratricopeptide repeat domain 9 39 2 0 0 2 0 hsa-miR-5001-5p -0.15 -0.15 N/A

SLC45A3 ENST00000367145.3 solute carrier family 45, member 3 17 1 0 0 1 1 hsa-miR-4498 -0.15 -0.15 N/A

EDA2R ENST00000374719.3 ectodysplasin A2 receptor 64 1 0 0 1 2 hsa-miR-5001-5p -0.15 -0.15 N/A

FAM129B ENST00000373314.3 family with sequence similarity 129, member B 516 1 0 1 0 1 hsa-miR-4498 -0.15 -0.15 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TAF5-like RNA polymerase II, p300/CBP-associated factor TAF5L ENST00000366676.1 5 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A (PCAF)-associated factor, 65kDa LRRN4CL ENST00000317449.4 LRRN4 C-terminal like 17 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A

HMG20A ENST00000336216.4 high mobility group 20A 391 2 0 2 0 0 hsa-miR-4498 -0.15 -0.15 N/A

CIRBP ENST00000444172.2 cold inducible RNA binding protein 4799 1 0 1 0 3 hsa-miR-4498 -0.15 -0.18 N/A

LRRC14 ENST00000292524.1 leucine rich repeat containing 14 469 2 1 1 0 3 hsa-miR-5001-5p -0.15 -0.42 N/A

GHDC ENST00000414034.3 GH3 domain containing 17 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

ETV6 ENST00000396373.4 ets variant 6 44 2 1 0 1 0 hsa-miR-5001-5p -0.15 -0.17 N/A

ARG2 ENST00000261783.3 arginase 2 6 1 0 0 1 0 hsa-miR-4498 -0.15 -0.18 N/A

TSNARE1 ENST00000519651.1 t-SNARE domain containing 1 11 3* 0 1 1 2 hsa-miR-5001-5p -0.15 -0.19 N/A

TCF12 ENST00000267811.5 transcription factor 12 101 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

AZGP1 ENST00000411734.1 alpha-2-glycoprotein 1, zinc-binding 11 1 0 1 0 2 hsa-miR-5001-5p -0.15 -0.15 N/A

PARS2 ENST00000371279.3 prolyl-tRNA synthetase 2, mitochondrial (putative) 266 1 0 1 0 0 hsa-miR-4498 -0.15 -0.16 N/A

ABCA3 ENST00000301732.5 ATP-binding cassette, sub-family A (ABC1), member 3 338 1 0 1 0 1 hsa-miR-4498 -0.15 -0.15 N/A

SH3BP5L ENST00000366472.5 SH3-binding domain protein 5-like 379 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

SHISA7 ENST00000376325.4 shisa family member 7 5 3 0 3 0 0 hsa-miR-4498 -0.15 -0.15 N/A

ADAMTSL4 ENST00000369038.2 ADAMTS-like 4 115 1 0 1 0 0 hsa-miR-4498 -0.15 -0.17 N/A

HAVCR1 ENST00000523175.1 hepatitis A virus cellular receptor 1 77 1 0 1 0 0 hsa-miR-4498 -0.15 -0.16 N/A

ABHD4 ENST00000428304.2 abhydrolase domain containing 4 102 2* 1 0 0 1 hsa-miR-5001-5p -0.15 -0.28 N/A

SNX11 ENST00000393405.2 sorting nexin 11 20 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.18 N/A

COL1A1 ENST00000225964.5 collagen, type I, alpha 1 73360 3 1 1 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

GRHL2 ENST00000251808.3 grainyhead-like 2 (Drosophila) 5 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

TWF2 ENST00000499914.2 twinfilin actin-binding protein 2 203 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

OSBPL7 ENST00000007414.3 oxysterol binding protein-like 7 25 2 0 0 2 1 hsa-miR-5001-5p -0.15 -0.15 N/A

LRRC20 ENST00000355790.4 leucine rich repeat containing 20 159 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

TMEM259 ENST00000333175.5 transmembrane protein 259 1339 2 0 2 0 2 hsa-miR-4498 -0.15 -0.15 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AHCY ENST00000217426.2 adenosylhomocysteinase 27 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.19 N/A

UNK ENST00000293218.3 unkempt homolog (Drosophila) 124 2 0 2 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

TMEM176B ENST00000492607.1 transmembrane protein 176B 994 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

DNAH17-AS1 ENST00000598378.1 DNAH17 antisense RNA 1 23 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

GDF5 ENST00000374369.3 growth differentiation factor 5 5 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

CACNB3 ENST00000301050.2 calcium channel, voltage-dependent, beta 3 subunit 41 1 0 1 0 1 hsa-miR-4498 -0.15 -0.15 N/A

UBE2Q1 ENST00000292211.4 ubiquitin-conjugating enzyme E2Q family member 1 3046 1 0 1 0 0 hsa-miR-4498 -0.15 -0.24 N/A

STK35 ENST00000381482.3 serine/threonine kinase 35 263 2 0 1 1 3 hsa-miR-5001-5p -0.15 -0.16 N/A

MAN1C1 ENST00000374332.4 mannosidase, alpha, class 1C, member 1 60 3 0 2 1 0 hsa-miR-4498 -0.15 -0.36 N/A

TGM4 ENST00000296125.4 transglutaminase 4 5 2 0 1 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

AIRE ENST00000329347.4 autoimmune regulator 23 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

ANKRD54 ENST00000215941.4 ankyrin repeat domain 54 5 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

KAT8 ENST00000448516.2 K(lysine) acetyltransferase 8 2490 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

KIF1B ENST00000377086.1 kinesin family member 1B 234 2 1 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

DSP ENST00000379802.3 desmoplakin 4571 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

MINOS1 ENST00000322753.6 mitochondrial inner membrane organizing system 1 287 1 0 1 0 0 hsa-miR-4498 -0.15 -0.18 N/A

C3orf36 ENST00000408895.2 chromosome 3 open reading frame 36 8 2 1 1 0 1 hsa-miR-5001-5p -0.15 -0.42 N/A

SCD ENST00000370355.2 stearoyl-CoA desaturase (delta-9-desaturase) 9726 1 0 0 1 0 hsa-miR-4498 -0.15 -0.15 N/A

GPX3 ENST00000517973.1 glutathione peroxidase 3 (plasma) 1142 1 0 1 0 1 hsa-miR-5001-5p -0.15 -0.15 N/A

STOML1 ENST00000564777.1 stomatin (EPB72)-like 1 18 2 1 1 0 1 hsa-miR-4498 -0.15 -0.21 N/A

PTGDR2 ENST00000332539.4 prostaglandin D2 receptor 2 170 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

NTSR1 ENST00000370501.3 neurotensin receptor 1 (high affinity) 37 1 0 1 0 7 hsa-miR-5001-5p -0.15 -0.15 N/A

XPC ENST00000285021.7 xeroderma pigmentosum, complementation group C 1827 2 0 2 0 0 hsa-miR-4498 -0.15 -0.15 N/A

MUC15 ENST00000455601.2 mucin 15, cell surface associated 7 1 0 0 1 1 hsa-miR-4498 -0.15 -0.15 N/A

ART4 ENST00000228936.4 ADP-ribosyltransferase 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score amyloid beta (A4) precursor protein-binding, family B, APBB3 ENST00000358580.5 9 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A member 3 ESRP2 ENST00000565858.1 epithelial splicing regulatory protein 2 320 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

RBMS2 ENST00000262031.5 RNA binding motif, single stranded interacting protein 2 451 1 0 1 0 1 hsa-miR-4498 -0.15 -0.27 N/A

MEF2D ENST00000464356.2 myocyte enhancer factor 2D 759 2 0 2 0 2 hsa-miR-4498 -0.15 -0.31 N/A

MMP17 ENST00000535291.1 matrix metallopeptidase 17 (membrane-inserted) 9 3 1 1 1 3 hsa-miR-5001-5p -0.15 -0.35 N/A

ORMDL3 ENST00000304046.2 ORM1-like 3 (S. cerevisiae) 82 1 0 1 0 0 hsa-miR-4498 -0.15 -0.23 N/A

POLH ENST00000372226.1 polymerase (DNA directed), eta 450 1 0 1 0 1 hsa-miR-4498 -0.15 -0.17 N/A

TMEM9 ENST00000367334.5 transmembrane protein 9 1769 3 0 3 0 2 hsa-miR-4498 -0.15 -0.61 N/A

CDYL2 ENST00000570137.2 chromodomain protein, Y-like 2 239 1 1 0 0 2 hsa-miR-5001-5p -0.15 -0.2 N/A

ITPRIP ENST00000337478.1 inositol 1,4,5-trisphosphate receptor interacting protein 1138 2 0 1 1 2 hsa-miR-4498 -0.15 -0.17 N/A

C19orf12 ENST00000592153.1 chromosome 19 open reading frame 12 242 1 0 0 1 2 hsa-miR-4498 -0.15 -0.15 N/A

ZNF276 ENST00000289816.5 zinc finger protein 276 94 3 0 2 1 1 hsa-miR-5001-5p -0.15 -0.45 N/A

ATP2A3 ENST00000309890.7 ATPase, Ca++ transporting, ubiquitous 40 1 1 0 0 3 hsa-miR-5001-5p -0.15 -0.15 N/A

CEACAM3 ENST00000221999.4 carcinoembryonic antigen-related cell adhesion molecule 3 5 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

CDH6 ENST00000265071.2 cadherin 6, type 2, K-cadherin (fetal kidney) 213 2 0 0 2 0 hsa-miR-5001-5p -0.15 -0.23 N/A

CCDC69 ENST00000355417.2 coiled-coil domain containing 69 22 1 0 1 0 3 hsa-miR-4498 -0.15 -0.17 N/A

ADH6 ENST00000394897.1 alcohol dehydrogenase 6 (class V) 17 1 0 1 0 0 hsa-miR-4498 -0.15 -0.2 N/A

FBXO45 ENST00000311630.6 F-box protein 45 72 2 1 0 1 0 hsa-miR-5001-5p -0.15 -0.38 N/A

SLC38A2 ENST00000256689.5 solute carrier family 38, member 2 696 1 0 1 0 0 hsa-miR-4498 -0.15 -0.16 N/A

C1orf116 ENST00000359470.5 chromosome 1 open reading frame 116 17 1 1 0 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

PABPC3 ENST00000281589.3 poly(A) binding protein, cytoplasmic 3 5 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

PRDM16 ENST00000511072.1 PR domain containing 16 64 3 0 2 1 1 hsa-miR-4498 -0.15 -0.32 N/A

C20orf196 ENST00000303142.6 chromosome 20 open reading frame 196 18 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

PTP4A1 ENST00000370651.3 protein tyrosine phosphatase type IVA, member 1 5740 2 1 0 1 0 hsa-miR-5001-5p -0.15 -0.36 N/A ATP-binding cassette, sub-family C (CFTR/MRP), member ABCC6 ENST00000205557.7 95 1 0 1 0 2 hsa-miR-4498 -0.15 -0.15 N/A 6 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FAM114A2 ENST00000351797.4 family with sequence similarity 114, member A2 385 1 0 0 1 1 hsa-miR-5001-5p -0.15 -0.15 N/A

FOXP3 ENST00000376207.4 forkhead box P3 7 1 0 1 0 2 hsa-miR-4498 -0.15 -0.15 N/A

FAM171A2 ENST00000293443.7 family with sequence similarity 171, member A2 85 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

FBN3 ENST00000600128.1 fibrillin 3 10 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

PTPRN2 ENST00000389413.3 protein tyrosine phosphatase, receptor type, N polypeptide 2 15 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

BTBD11 ENST00000280758.5 BTB (POZ) domain containing 11 9 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A serpin peptidase inhibitor, clade H (heat shock protein 47), SERPINH1 ENST00000533603.1 5956 1 0 1 0 2 hsa-miR-4498 -0.15 -0.15 N/A member 1, (collagen binding protein 1) PCYT1B ENST00000379145.1 phosphate cytidylyltransferase 1, choline, beta 5 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A

PRR26 ENST00000441152.2 proline rich 26 5 1 0 1 0 0 hsa-miR-5001-5p -0.15 -0.15 N/A leucine rich repeat and fibronectin type III domain LRFN1 ENST00000248668.4 82 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A containing 1 PHLPP1 ENST00000400316.4 PH domain and leucine rich repeat protein phosphatase 1 348 1 0 0 1 0 hsa-miR-5001-5p -0.15 -0.15 N/A

ZDHHC3 ENST00000296127.3 zinc finger, DHHC-type containing 3 426 5 1 2 2 7 hsa-miR-5001-5p -0.15 -0.63 N/A

ZFHX2 ENST00000419474.3 zinc finger homeobox 2 7 2 1 1 0 1 hsa-miR-5001-5p -0.15 -0.53 N/A

ZNF282 ENST00000479907.1 zinc finger protein 282 3014 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

ZNF362 ENST00000539719.1 zinc finger protein 362 27 1 0 1 0 0 hsa-miR-4498 -0.15 -0.15 N/A

RSAD2 ENST00000382040.3 radical S-adenosyl methionine domain containing 2 5 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

HYOU1 ENST00000404233.3 hypoxia up-regulated 1 29 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

RP11-366L20.2 ENST00000356215.2 Uncharacterized protein 5 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A

DCLK3 ENST00000416516.2 doublecortin-like kinase 3 5 1 0 1 0 2 hsa-miR-4498 -0.14 -0.14 N/A

CRAT ENST00000318080.2 carnitine O-acetyltransferase 1867 1 0 1 0 1 hsa-miR-5001-5p -0.14 -0.14 N/A pterin-4 alpha-carbinolamine dehydratase/dimerization PCBD2 ENST00000512783.1 95 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 STAT1 ENST00000540176.1 signal transducer and activator of transcription 1, 91kDa 326 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

PHOX2B ENST00000226382.2 paired-like homeobox 2b 5 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A thiosulfate sulfurtransferase (rhodanese)-like domain TSTD2 ENST00000341170.4 219 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A containing 2 solute carrier family 1 (glutamate/neutral amino acid SLC1A4 ENST00000234256.3 380 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.16 N/A transporter), member 4 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score OSGIN1 ENST00000343939.2 oxidative stress induced growth inhibitor 1 7 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A

FABP2 ENST00000274024.3 fatty acid binding protein 2, intestinal 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

XIAP ENST00000371199.3 X-linked inhibitor of apoptosis 153 1 0 1 0 0 hsa-miR-4498 -0.14 -0.24 N/A

ALDH5A1 ENST00000357578.3 aldehyde dehydrogenase 5 family, member A1 325 2 0 2 0 1 hsa-miR-4498 -0.14 -0.26 N/A

MPLKIP ENST00000306984.6 M-phase specific PLK1 interacting protein 32 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.32 N/A

COMP ENST00000542601.2 cartilage oligomeric matrix protein 5 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A interleukin 6 signal transducer (gp130, oncostatin M IL6ST ENST00000381287.4 213 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A receptor) RFXAP ENST00000255476.2 regulatory factor X-associated protein 682 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

SLC16A14 ENST00000295190.4 solute carrier family 16, member 14 34 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

PALM2 ENST00000448454.2 paralemmin 2 35 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.18 N/A

ASPA ENST00000263080.2 aspartoacylase 5 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

CDK16 ENST00000457458.2 cyclin-dependent kinase 16 2095 2 1 1 0 2 hsa-miR-5001-5p -0.14 -0.54 N/A

ASCL2 ENST00000331289.4 achaete-scute complex homolog 2 (Drosophila) 5 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A

NUP155 ENST00000231498.3 nucleoporin 155kDa 814 2 1 1 0 0 hsa-miR-4498 -0.14 -0.26 N/A

RP5-1052I5.2 ENST00000370548.2 Heparan sulfate 2-O-sulfotransferase 1 21 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

CYP1A1 ENST00000379727.3 cytochrome P450, family 1, subfamily A, polypeptide 1 837 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

EIF1AX ENST00000379607.5 eukaryotic translation initiation factor 1A, X-linked 277 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

TMEM170A ENST00000357613.4 transmembrane protein 170A 70 2 0 0 2 0 hsa-miR-5001-5p -0.14 -0.23 N/A

MORC4 ENST00000535534.1 MORC family CW-type zinc finger 4 112 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.16 N/A

FAM109A ENST00000361483.3 family with sequence similarity 109, member A 780 1 0 0 1 2 hsa-miR-5001-5p -0.14 -0.14 N/A

LMTK2 ENST00000297293.5 lemur tyrosine kinase 2 51 2 0 0 2 1 hsa-miR-5001-5p -0.14 -0.33 N/A

UPP2 ENST00000605860.1 uridine phosphorylase 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. NUS1 ENST00000368494.3 302 1 0 0 1 0 hsa-miR-4498 -0.14 -0.14 N/A cerevisiae) LGALS12 ENST00000340246.5 lectin, galactoside-binding, soluble, 12 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

SQSTM1 ENST00000389805.4 sequestosome 1 5047 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.15 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score POFUT1 ENST00000375749.3 protein O-fucosyltransferase 1 647 1 0 1 0 1 hsa-miR-4498 -0.14 -0.3 N/A

PITPNA ENST00000313486.7 phosphatidylinositol transfer protein, alpha 366 2 1 0 1 1 hsa-miR-5001-5p -0.14 -0.34 N/A

MEGF6 ENST00000294599.4 multiple EGF-like-domains 6 143 3 0 2 1 1 hsa-miR-5001-5p -0.14 -0.16 N/A

RAD9B ENST00000409425.1 RAD9 homolog B (S. pombe) 10 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

TRPS1 ENST00000395715.3 trichorhinophalangeal syndrome I 94 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

PHF16 ENST00000397189.1 PHD finger protein 16 95 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

RCC2 ENST00000375436.4 regulator of chromosome condensation 2 180 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A

NTNG1 ENST00000370067.1 netrin G1 5 1 0 0 1 3 hsa-miR-5001-5p -0.14 -0.14 N/A

GMEB2 ENST00000370069.1 glucocorticoid modulatory element binding protein 2 240 1 1 0 0 3 hsa-miR-4498 -0.14 -0.14 N/A

ZNF592 ENST00000299927.3 zinc finger protein 592 1128 2 0 2 0 1 hsa-miR-4498 -0.14 -0.17 N/A

OLIG2 ENST00000382357.3 oligodendrocyte lineage transcription factor 2 15 1 0 1 0 1 hsa-miR-4498 -0.14 -0.17 N/A

MSL2 ENST00000309993.2 male-specific lethal 2 homolog (Drosophila) 175 1 0 0 1 0 hsa-miR-4498 -0.14 -0.14 N/A

ARCN1 ENST00000359415.4 archain 1 1139 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

ZPLD1 ENST00000306176.1 zona pellucida-like domain containing 1 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

TMEM140 ENST00000275767.3 transmembrane protein 140 858 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

FZD7 ENST00000286201.1 frizzled family receptor 7 319 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

KLC2 ENST00000394065.2 kinesin light chain 2 11832 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

ENGASE ENST00000579016.1 endo-beta-N-acetylglucosaminidase 33 4 1 3 0 1 hsa-miR-5001-5p -0.14 -0.2 N/A

EPHB2 ENST00000374632.3 EPH receptor B2 297 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

ZNF2 ENST00000398107.2 zinc finger protein 2 95 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.17 N/A

CAMK2N2 ENST00000296238.3 calcium/calmodulin-dependent protein kinase II inhibitor 2 39 1 0 1 0 1 hsa-miR-5001-5p -0.14 -0.14 N/A

TUBGCP6 ENST00000439308.2 tubulin, gamma complex associated protein 6 1062 1 0 1 0 1 hsa-miR-5001-5p -0.14 -0.14 N/A

UBL4B ENST00000334179.3 ubiquitin-like 4B 5 1 0 1 0 2 hsa-miR-5001-5p -0.14 -0.14 N/A

RCSD1 ENST00000367854.3 RCSD domain containing 1 32 1 0 0 1 1 hsa-miR-4498 -0.14 -0.14 N/A

JPH2 ENST00000372980.3 junctophilin 2 76 2 1 1 0 0 hsa-miR-5001-5p -0.14 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score COPS8 ENST00000354371.2 COP9 signalosome subunit 8 1979 4 1 1 2 4 hsa-miR-5001-5p -0.14 -0.85 N/A

AVPR1A ENST00000299178.2 arginine vasopressin receptor 1A 9 1 0 1 0 1 hsa-miR-4498 -0.14 -0.31 N/A

STYX ENST00000354586.4 serine/threonine/tyrosine interacting protein 250 1 0 1 0 0 hsa-miR-4498 -0.14 -0.3 N/A signal transducer and activator of transcription 3 (acute- STAT3 ENST00000585517.1 478 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.15 N/A phase response factor) RP11-429E11.3 ENST00000317652.1 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

ZNF585A ENST00000356958.4 zinc finger protein 585A 77 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

TBR1 ENST00000389554.3 T-box, brain, 1 5 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

VPS13B ENST00000395996.1 vacuolar protein sorting 13 homolog B (yeast) 262 2 0 1 1 3 hsa-miR-5001-5p -0.14 -0.14 N/A

FAM57B ENST00000564806.1 family with sequence similarity 57, member B 5 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

JAK3 ENST00000458235.1 Janus kinase 3 9 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

TUB ENST00000305253.4 tubby bipartite transcription factor 743 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A hexose-6-phosphate dehydrogenase (glucose 1- H6PD ENST00000377403.2 467 2 0 1 1 3 hsa-miR-5001-5p -0.14 -0.14 N/A dehydrogenase) ZNF74 ENST00000357502.5 zinc finger protein 74 142 1 1 0 0 0 hsa-miR-5001-5p -0.14 -0.3 N/A

AR ENST00000374690.3 androgen receptor 57 2 0 1 1 0 hsa-miR-4498 -0.14 -0.14 N/A

TMPRSS4 ENST00000534111.1 transmembrane protease, serine 4 5 3 0 1 2 1 hsa-miR-5001-5p -0.14 -0.14 N/A

CCSER2 ENST00000224756.8 coiled-coil serine-rich protein 2 123 1 0 0 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A

SUSD2 ENST00000358321.3 sushi domain containing 2 16 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

RDH16 ENST00000398138.3 retinol dehydrogenase 16 (all-trans) 13 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

C10orf90 ENST00000284694.7 chromosome 10 open reading frame 90 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

AC026703.1 ENST00000326958.1 182 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

KLK2 ENST00000358049.4 kallikrein-related peptidase 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

TNF ENST00000449264.2 tumor necrosis factor 5 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

C5orf51 ENST00000381647.2 chromosome 5 open reading frame 51 124 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

PLOD1 ENST00000196061.4 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 5056 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

CXorf28 ENST00000457435.1 chromosome X open reading frame 28 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ALPL ENST00000374840.3 alkaline phosphatase, liver/bone/kidney 251 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

ANKS3 ENST00000304283.4 ankyrin repeat and sterile alpha motif domain containing 3 6 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

C15orf38-AP3S2 ENST00000398333.3 C15orf38-AP3S2 readthrough 985 2 0 1 1 1 hsa-miR-5001-5p -0.14 -0.25 N/A

ACAP3 ENST00000354700.5 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 301 1 0 1 0 4 hsa-miR-4498 -0.14 -0.23 N/A nucleus accumbens associated 1, BEN and BTB (POZ) NACC1 ENST00000292431.4 337 1 0 1 0 2 hsa-miR-5001-5p -0.14 -0.14 N/A domain containing solute carrier family 25 (mitochondrial carrier; phosphate SLC25A25 ENST00000373069.5 3454 2 0 1 1 1 hsa-miR-5001-5p -0.14 -0.14 N/A carrier), member 25 ADAP2 ENST00000330889.3 ArfGAP with dual PH domains 2 16 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

FAM131C ENST00000375662.4 family with sequence similarity 131, member C 5 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

RXRB ENST00000374685.4 retinoid X receptor, beta 46 2 0 2 0 0 hsa-miR-5001-5p -0.14 -0.22 N/A

KIF13A ENST00000378814.5 kinesin family member 13A 725 2 0 1 1 0 hsa-miR-4498 -0.14 -0.14 N/A

MEX3A ENST00000532414.2 mex-3 RNA binding family member A 912 2 1 0 1 1 hsa-miR-4498 -0.14 -0.17 N/A

EPB41L3 ENST00000341928.2 erythrocyte membrane protein band 4.1-like 3 179 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.19 N/A

RAB8A ENST00000300935.3 RAB8A, member RAS oncogene family 226 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

MOSPD2 ENST00000380492.3 motile sperm domain containing 2 76 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

ZNF853 ENST00000457543.3 zinc finger protein 853 8 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

MSRB1 ENST00000399753.2 methionine sulfoxide reductase B1 2102 1 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

FABP7 ENST00000356535.4 fatty acid binding protein 7, brain 5 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

GCK ENST00000403799.3 glucokinase (hexokinase 4) 5 1 0 1 0 2 hsa-miR-4498 -0.14 -0.14 N/A

BYSL ENST00000230340.4 bystin-like 1995 2 1 1 0 0 hsa-miR-5001-5p -0.14 -0.59 N/A

PHF8 ENST00000338946.6 PHD finger protein 8 85 1 0 1 0 0 hsa-miR-4498 -0.14 -0.15 N/A

KNOP1 ENST00000219837.7 lysine-rich nucleolar protein 1 157 2 1 1 0 1 hsa-miR-5001-5p -0.14 -0.23 N/A CTD (carboxy-terminal domain, RNA polymerase II, CTDSP2 ENST00000398073.2 991 1 0 1 0 1 hsa-miR-5001-5p -0.14 -0.14 N/A polypeptide A) small phosphatase 2 NPFFR1 ENST00000277942.6 neuropeptide FF receptor 1 5 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

RWDD2A ENST00000369724.4 RWD domain containing 2A 286 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A

INPP5A ENST00000368594.3 inositol polyphosphate-5-phosphatase, 40kDa 243 1 0 1 0 0 hsa-miR-5001-5p -0.14 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score IGHMBP2 ENST00000255078.3 immunoglobulin mu binding protein 2 34 1 0 1 0 1 hsa-miR-4498 -0.14 -0.14 N/A

ACER2 ENST00000340967.2 alkaline ceramidase 2 44 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

DAND5 ENST00000585548.1 DAN domain family member 5, BMP antagonist 11 2* 0 0 1 0 hsa-miR-5001-5p -0.14 -0.14 N/A

RORC ENST00000356728.6 RAR-related orphan receptor C 42 1 0 1 0 0 hsa-miR-4498 -0.14 -0.14 N/A

HMGCS2 ENST00000369406.3 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 63 1 1 0 0 1 hsa-miR-5001-5p -0.13 -0.6 N/A

EHD3 ENST00000322054.5 EH-domain containing 3 206 3 0 1 2 5 hsa-miR-4498 -0.13 -0.31 N/A

SYT11 ENST00000368324.4 synaptotagmin XI 750 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.14 N/A

KIF5C ENST00000435030.1 kinesin family member 5C 19 1 1 0 0 0 hsa-miR-5001-5p -0.13 -0.23 N/A

ZHX3 ENST00000309060.3 zinc fingers and homeoboxes 3 131 2 0 0 2 1 hsa-miR-5001-5p -0.13 -0.22 N/A

DIRAS1 ENST00000323469.4 DIRAS family, GTP-binding RAS-like 1 49 1 0 1 0 0 hsa-miR-4498 -0.13 -0.17 N/A

UNC5C ENST00000453304.1 unc-5 homolog C (C. elegans) 60 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.19 N/A

CALHM1 ENST00000329905.5 calcium homeostasis modulator 1 5 1 0 1 0 1 hsa-miR-5001-5p -0.13 -0.13 N/A

RIN3 ENST00000216487.7 Ras and Rab interactor 3 38 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

SP7 ENST00000536324.2 Sp7 transcription factor 5 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

PGM5 ENST00000396396.1 phosphoglucomutase 5 23 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

EIF5A ENST00000336452.7 eukaryotic translation initiation factor 5A 756 1 0 1 0 1 hsa-miR-5001-5p -0.13 -0.14 N/A

SLC26A9 ENST00000367135.3 solute carrier family 26 (anion exchanger), member 9 18 1 0 0 1 0 hsa-miR-762 -0.13 -0.13 N/A

HAPLN4 ENST00000291481.7 hyaluronan and proteoglycan link protein 4 16 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

IYD ENST00000344419.3 iodotyrosine deiodinase 5 1 0 0 1 4 hsa-miR-4498 -0.13 -0.13 N/A

ZNF385B ENST00000410066.1 zinc finger protein 385B 17 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

SPATA3 ENST00000452881.1 spermatogenesis associated 3 5 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PITX1 ENST00000265340.7 paired-like homeodomain 1 1502 1 1 0 0 2 hsa-miR-4498 -0.13 -0.13 N/A

INSIG2 ENST00000245787.4 insulin induced gene 2 562 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.16 N/A

C19orf55 ENST00000544099.1 chromosome 19 open reading frame 55 59 1 0 1 0 0 hsa-miR-4498 -0.13 -0.3 N/A

UBE2H ENST00000355621.3 ubiquitin-conjugating enzyme E2H 855 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score METTL8 ENST00000375258.4 methyltransferase like 8 124 2 0 0 2 0 hsa-miR-4498 -0.13 -0.27 N/A

CEP72 ENST00000444221.1 centrosomal protein 72kDa 230 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

C7 ENST00000313164.9 complement component 7 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

CASKIN1 ENST00000343516.6 CASK interacting protein 1 6 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

AK4 ENST00000545314.1 adenylate kinase 4 116 1 1 0 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A

SLC43A3 ENST00000395123.2 solute carrier family 43, member 3 642 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A

ARHGAP32 ENST00000524655.1 Rho GTPase activating protein 32 13 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PPP1R16A ENST00000292539.4 protein phosphatase 1, regulatory subunit 16A 7450 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

ZBTB37 ENST00000367701.5 zinc finger and BTB domain containing 37 213 2 0 1 1 1 hsa-miR-5001-5p -0.13 -0.15 N/A

KAT7 ENST00000259021.4 K(lysine) acetyltransferase 7 48 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

CD72 ENST00000396757.1 CD72 molecule 7 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.2 N/A

C8orf82 ENST00000313465.5 chromosome 8 open reading frame 82 94 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A translocase of inner mitochondrial membrane 13 homolog TIMM13 ENST00000215570.3 5135 1 0 0 1 2 hsa-miR-5001-5p -0.13 -0.26 N/A (yeast) TRIM8 ENST00000302424.7 tripartite motif containing 8 525 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

SPATA5 ENST00000274008.4 spermatogenesis associated 5 168 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.16 N/A

ZNF490 ENST00000311437.6 zinc finger protein 490 97 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

NAV2 ENST00000360655.4 neuron navigator 2 337 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A

FBXL7 ENST00000504595.1 F-box and leucine-rich repeat protein 7 16 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

CAND2 ENST00000456430.2 cullin-associated and neddylation-dissociated 2 (putative) 92 1 1 0 0 0 hsa-miR-4498 -0.13 -0.13 N/A

FNBP1L ENST00000370253.2 formin binding protein 1-like 219 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

ASCL5 ENST00000449188.2 achaete-scute complex homolog 5 (Drosophila) 12 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PIM2 ENST00000376509.4 pim-2 oncogene 77 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

LPPR4 ENST00000370185.3 Lipid phosphate phosphatase-related protein type 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

NCR3LG1 ENST00000338965.4 natural killer cell cytotoxicity receptor 3 ligand 1 214 1 0 1 0 2 hsa-miR-4498 -0.13 -0.13 N/A peroxisome proliferator-activated receptor gamma, PPARGC1B ENST00000309241.5 12 4 2 0 2 1 hsa-miR-5001-5p -0.13 -0.17 N/A coactivator 1 beta Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RNASEH2C ENST00000308418.4 ribonuclease H2, subunit C 1330 2 0 1 1 4 hsa-miR-4498 -0.13 -0.38 N/A

LIMD2 ENST00000259006.3 LIM domain containing 2 90 4 0 3 1 1 hsa-miR-4498 -0.13 -0.47 N/A

GK5 ENST00000392993.2 glycerol kinase 5 (putative) 73 2 1 1 0 0 hsa-miR-4498 -0.13 -0.42 N/A

SDK1 ENST00000404826.2 sidekick cell adhesion molecule 1 60 3 1 2 0 2 hsa-miR-4498 -0.13 -0.17 N/A

TMEM91 ENST00000539627.1 transmembrane protein 91 231 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A

IMPG1 ENST00000369963.3 interphotoreceptor matrix proteoglycan 1 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

TBXA2R ENST00000375190.4 thromboxane A2 receptor 169 1 0 0 1 0 hsa-miR-762 -0.13 -0.13 N/A

ATG9A ENST00000396761.2 autophagy related 9A 50 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

IL22RA1 ENST00000270800.1 interleukin 22 receptor, alpha 1 5 1 0 0 1 0 hsa-miR-4498 -0.13 -0.13 N/A

CSNK2A2 ENST00000262506.3 casein kinase 2, alpha prime polypeptide 99 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

RBM28 ENST00000223073.2 RNA binding motif protein 28 297 5 2 2 1 5 hsa-miR-5001-5p -0.13 -0.48 N/A

WWC1 ENST00000265293.4 WW and C2 domain containing 1 43 1 0 1 0 1 hsa-miR-5001-5p -0.13 -0.16 N/A

ATOX1 ENST00000521264.1 antioxidant 1 copper chaperone 43 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.15 N/A

OXCT1 ENST00000196371.5 3-oxoacid CoA transferase 1 1783 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.15 N/A

COL13A1 ENST00000398974.3 collagen, type XIII, alpha 1 628 1 1 0 0 0 hsa-miR-5001-5p -0.13 -0.22 N/A

HOXD4 ENST00000306324.3 homeobox D4 214 1 0 0 1 2 hsa-miR-5001-5p -0.13 -0.14 N/A

IL3RA ENST00000331035.4 interleukin 3 receptor, alpha (low affinity) 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PRRX1 ENST00000367760.3 paired related homeobox 1 57 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

SLC35E2B ENST00000378662.1 solute carrier family 35, member E2B 5 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

RNF40 ENST00000324685.6 ring finger protein 40, E3 ubiquitin protein ligase 773 2 0 2 0 0 hsa-miR-4498 -0.13 -0.13 N/A solute carrier family 24 (sodium/potassium/calcium SLC24A2 ENST00000341998.2 5 1 0 1 0 2 hsa-miR-5001-5p -0.13 -0.13 N/A exchanger), member 2 golgi-associated, gamma adaptin ear containing, ARF GGA1 ENST00000343632.4 325 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A binding protein 1 DLG3 ENST00000194900.4 discs, large homolog 3 (Drosophila) 185 2 0 2 0 2 hsa-miR-4498 -0.13 -0.22 N/A

ASB13 ENST00000357700.6 ankyrin repeat and SOCS box containing 13 1578 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

USP5 ENST00000229268.8 ubiquitin specific peptidase 5 (isopeptidase T) 104 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ATAD3A ENST00000536055.1 ATPase family, AAA domain containing 3A 23 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

PPAN-P2RY11 ENST00000428358.1 PPAN-P2RY11 readthrough 293 2 0 0 2 1 hsa-miR-5001-5p -0.13 -0.13 N/A

PGBD4 ENST00000397766.2 piggyBac transposable element derived 4 136 1 0 1 0 1 hsa-miR-4498 -0.13 -0.14 N/A

RPL7 ENST00000396467.1 ribosomal protein L7 271 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.23 N/A mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N- MGAT1 ENST00000333055.3 831 2 0 0 2 0 hsa-miR-5001-5p -0.13 -0.23 N/A acetylglucosaminyltransferase ACTR3 ENST00000263238.2 ARP3 actin-related protein 3 homolog (yeast) 816 1 0 1 0 0 hsa-miR-4498 -0.13 -0.19 N/A

WDFY2 ENST00000298125.5 WD repeat and FYVE domain containing 2 85 5 1 0 4 0 hsa-miR-5001-5p -0.13 -0.81 N/A

IQCE ENST00000402050.2 IQ motif containing E 687 3 1 0 2 0 hsa-miR-5001-5p -0.13 -0.13 N/A

SCN1B ENST00000262631.5 sodium channel, voltage-gated, type I, beta subunit 72 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

ATF7IP ENST00000261168.4 activating transcription factor 7 interacting protein 667 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A

C10orf85 ENST00000369071.2 chromosome 10 open reading frame 85 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PEX11A ENST00000300056.3 peroxisomal biogenesis factor 11 alpha 82 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A

CHRDL1 ENST00000372045.1 chordin-like 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A

ITGA10 ENST00000369304.3 integrin, alpha 10 62 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

SCARF1 ENST00000571272.1 scavenger receptor class F, member 1 5 1 0 1 0 2 hsa-miR-5001-5p -0.13 -0.13 N/A

LYSMD4 ENST00000409796.1 LysM, putative peptidoglycan-binding, domain containing 4 1344 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

GAN ENST00000568107.2 gigaxonin 185 2 0 1 1 3 hsa-miR-5001-5p -0.13 -0.22 N/A

CEP89 ENST00000305768.5 centrosomal protein 89kDa 37 2 0 0 2 2 hsa-miR-5001-5p -0.13 -0.26 N/A

KLHL18 ENST00000232766.5 kelch-like family member 18 74 2 0 2 0 1 hsa-miR-4498 -0.13 -0.23 N/A

ZFYVE27 ENST00000453958.2 zinc finger, FYVE domain containing 27 565 1 0 0 1 2 hsa-miR-5001-5p -0.13 -0.13 N/A

KIAA1244 ENST00000251691.4 KIAA1244 169 2 0 2 0 0 hsa-miR-4498 -0.13 -0.14 N/A

SURF4 ENST00000545297.1 surfeit 4 3667 1 0 1 0 3 hsa-miR-4498 -0.13 -0.19 N/A tetratricopeptide repeat, ankyrin repeat and coiled-coil TANC1 ENST00000263635.6 618 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A containing 1 CPLX1 ENST00000304062.6 complexin 1 49 1 0 1 0 2 hsa-miR-4498 -0.13 -0.13 N/A Uncharacterized protein; cDNA FLJ46300 fis, clone AL450307.1 ENST00000341866.3 5 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A TESTI4035989 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score JAKMIP3 ENST00000298622.4 Janus kinase and microtubule interacting protein 3 5 3 0 2 1 2 hsa-miR-4498 -0.13 -0.13 N/A

TCF4 ENST00000354452.3 transcription factor 4 394 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

CNNM1 ENST00000356713.4 cyclin M1 45 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A membrane-associated ring finger (C3HC4) 1, E3 ubiquitin MARCH1 ENST00000274056.7 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A protein ligase CBR1 ENST00000530908.1 carbonyl reductase 1 113 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A adenylate cyclase activating polypeptide 1 (pituitary) ADCYAP1R1 ENST00000304166.4 9 1 1 0 0 4 hsa-miR-5001-5p -0.13 -0.16 N/A receptor type I PYCR2 ENST00000343818.6 pyrroline-5-carboxylate reductase family, member 2 1190 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

GLRX ENST00000379979.4 glutaredoxin (thioltransferase) 79 1 0 1 0 1 hsa-miR-5001-5p -0.13 -0.37 N/A

COMT ENST00000361682.6 catechol-O-methyltransferase 323 3 1 2 0 1 hsa-miR-4498 -0.13 -0.77 N/A

TRIM9 ENST00000298355.3 tripartite motif containing 9 45 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A Ras association (RalGDS/AF-6) domain family (N-terminal) RASSF7 ENST00000397582.3 147 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.13 N/A member 7 NEURL1B ENST00000369800.5 neuralized homolog 1B (Drosophila) 5 4 0 3 1 1 hsa-miR-5001-5p -0.13 -0.13 N/A

ENPP7 ENST00000328313.5 ectonucleotide pyrophosphatase/phosphodiesterase 7 13 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

HOXB9 ENST00000311177.5 homeobox B9 8 1 0 0 1 1 hsa-miR-5001-5p -0.13 -0.21 N/A

NMT2 ENST00000378165.4 N-myristoyltransferase 2 318 1 1 0 0 1 hsa-miR-5001-5p -0.13 -0.37 N/A

STRIP2 ENST00000249344.2 striatin interacting protein 2 87 1 0 1 0 1 hsa-miR-4498 -0.13 -0.19 N/A

PMVK ENST00000368467.3 phosphomevalonate kinase 498 1 1 0 0 1 hsa-miR-4498 -0.13 -0.46 N/A

FAM168A ENST00000064778.4 family with sequence similarity 168, member A 68 1 0 1 0 1 hsa-miR-4498 -0.13 -0.19 N/A

PREPL ENST00000541738.1 prolyl endopeptidase-like 612 1 0 1 0 0 hsa-miR-4498 -0.13 -0.16 N/A

BCAP29 ENST00000005259.4 B-cell receptor-associated protein 29 326 1 0 1 0 0 hsa-miR-5001-5p -0.13 -0.2 N/A

MT1A ENST00000290705.8 metallothionein 1A 19 2 1 1 0 3 hsa-miR-4498 -0.13 -0.72 N/A

NCAN ENST00000252575.6 neurocan 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

PPP2R5E ENST00000337537.3 protein phosphatase 2, regulatory subunit B', epsilon isoform 23 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

IMPG2 ENST00000193391.7 interphotoreceptor matrix proteoglycan 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

ACTRT3 ENST00000330368.2 actin-related protein T3 244 2 0 2 0 0 hsa-miR-4498 -0.13 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GRIN2B ENST00000609686.1 glutamate receptor, ionotropic, N-methyl D-aspartate 2B 5 4 1 0 3 2 hsa-miR-5001-5p -0.13 -0.13 N/A

POU3F1 ENST00000373012.2 POU class 3 homeobox 1 9 1 0 1 0 2 hsa-miR-5001-5p -0.13 -0.13 N/A

RCOR2 ENST00000301459.4 REST corepressor 2 5 1 0 1 0 0 hsa-miR-4498 -0.13 -0.13 N/A

XPO7 ENST00000252512.9 exportin 7 647 1 0 1 0 0 hsa-miR-4498 -0.13 -0.14 N/A

LPGAT1 ENST00000366997.4 lysophosphatidylglycerol acyltransferase 1 135 1 0 1 0 0 hsa-miR-4498 -0.13 -0.19 N/A

SMAD5 ENST00000545279.1 SMAD family member 5 225 1 0 0 1 0 hsa-miR-5001-5p -0.13 -0.2 N/A

TRAF3 ENST00000560371.1 TNF receptor-associated factor 3 833 3 0 1 2 5 hsa-miR-5001-5p -0.13 -0.17 N/A

SYT6 ENST00000607941.1 synaptotagmin VI 5 1 0 1 0 1 hsa-miR-4498 -0.13 -0.13 N/A

GRPEL1 ENST00000264954.4 GrpE-like 1, mitochondrial (E. coli) 1416 1 1 0 0 1 hsa-miR-5001-5p -0.13 -0.37 N/A

ZKSCAN8 ENST00000330236.6 zinc finger with KRAB and SCAN domains 8 281 2 0 1 1 0 hsa-miR-5001-5p -0.13 -0.13 N/A

SPHK2 ENST00000245222.4 sphingosine kinase 2 142 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

HIST2H2AA4 ENST00000369159.2 histone cluster 2, H2aa4 5 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

UBALD2 ENST00000327490.6 UBA-like domain containing 2 506 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

GAL3ST1 ENST00000406955.1 galactose-3-O-sulfotransferase 1 470 1 0 1 0 0 hsa-miR-5001-5p -0.12 -0.12 N/A

RPTOR ENST00000306801.3 regulatory associated protein of MTOR, complex 1 190 3 0 2 1 2 hsa-miR-5001-5p -0.12 -0.19 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS2 ENST00000251582.7 2767 1 1 0 0 0 hsa-miR-5001-5p -0.12 -0.12 N/A 2 PROM2 ENST00000317620.9 prominin 2 18 1 1 0 0 2 hsa-miR-5001-5p -0.12 -0.12 N/A

PNMA3 ENST00000447306.1 paraneoplastic Ma antigen 3 5 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

WASF3 ENST00000335327.5 WAS protein family, member 3 24 1 0 1 0 2 hsa-miR-4498 -0.12 -0.13 N/A

NFYA ENST00000341376.6 nuclear transcription factor Y, alpha 177 2 0 1 1 1 hsa-miR-5001-5p -0.12 -0.28 N/A

NFRKB ENST00000446488.3 nuclear factor related to kappaB binding protein 21 2 0 1 1 0 hsa-miR-4498 -0.12 -0.23 N/A

ACACA ENST00000353139.5 acetyl-CoA carboxylase alpha 306 1 1 0 0 5 hsa-miR-4498 -0.12 -0.16 N/A

NARF ENST00000309794.11 nuclear prelamin A recognition factor 610 1 0 1 0 0 hsa-miR-4498 -0.12 -0.16 N/A

MUC13 ENST00000311075.3 mucin 13, cell surface associated 43 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.21 N/A golgi brefeldin A resistant guanine nucleotide exchange GBF1 ENST00000369983.3 1009 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A factor 1 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RAB40C ENST00000248139.3 RAB40C, member RAS oncogene family 421 2 0 1 1 2 hsa-miR-4498 -0.12 -0.12 N/A

C7orf72 ENST00000297001.6 chromosome 7 open reading frame 72 5 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

ENTPD5 ENST00000334696.6 ectonucleoside triphosphate diphosphohydrolase 5 105 2 0 0 2 0 hsa-miR-5001-5p -0.12 -0.17 N/A

GPR132 ENST00000329797.3 G protein-coupled receptor 132 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

ELMSAN1 ENST00000394071.2 ELM2 and Myb/SANT-like domain containing 1 15 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

NKD1 ENST00000268459.3 naked cuticle homolog 1 (Drosophila) 26 5 0 3 2 2 hsa-miR-4498 -0.12 -0.4 N/A

NUDCD2 ENST00000302764.4 NudC domain containing 2 308 2 1 1 0 0 hsa-miR-4498 -0.12 -0.42 N/A

TNFRSF10B ENST00000276431.4 tumor necrosis factor receptor superfamily, member 10b 828 1 0 1 0 0 hsa-miR-4498 -0.12 -0.17 N/A

AC074212.3 ENST00000457052.2 Uncharacterized protein 5 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

EXPH5 ENST00000265843.4 exophilin 5 49 1 0 1 0 0 hsa-miR-4498 -0.12 -0.15 N/A

CD1A ENST00000289429.5 CD1a molecule 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

BTN2A1 ENST00000429381.1 butyrophilin, subfamily 2, member A1 839 1 0 1 0 2 hsa-miR-4498 -0.12 -0.12 N/A

FBLN7 ENST00000331203.2 fibulin 7 44 4 0 1 3 1 hsa-miR-5001-5p -0.12 -0.27 N/A UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- GALNT13 ENST00000409237.1 49 1 0 1 0 0 hsa-miR-4498 -0.12 -0.18 N/A acetylgalactosaminyltransferase 13 (GalNAc-T13) AGO3 ENST00000373191.4 argonaute RISC catalytic component 3 198 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.31 N/A

EIF5 ENST00000216554.3 eukaryotic translation initiation factor 5 970 2 0 1 1 0 hsa-miR-4498 -0.12 -0.34 N/A

UBE2J2 ENST00000347370.2 ubiquitin-conjugating enzyme E2, J2 3002 1 0 1 0 1 hsa-miR-4498 -0.12 -0.16 N/A

MYO18A ENST00000354329.4 myosin XVIIIA 159 3 0 2 1 1 hsa-miR-5001-5p -0.12 -0.16 N/A

ALKBH5 ENST00000399138.4 alkB, alkylation repair homolog 5 (E. coli) 2211 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

KLF7 ENST00000423015.1 Kruppel-like factor 7 (ubiquitous) 737 1 0 1 0 0 hsa-miR-5001-5p -0.12 -0.12 N/A

PJA2 ENST00000361189.2 praja ring finger 2, E3 ubiquitin protein ligase 220 1 1 0 0 0 hsa-miR-5001-5p -0.12 -0.36 N/A

EIF5AL1 ENST00000520547.2 eukaryotic translation initiation factor 5A-like 1 10 1 0 1 0 1 hsa-miR-5001-5p -0.12 -0.12 N/A

DAO ENST00000228476.3 D-amino-acid oxidase 26 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

ZCCHC3 ENST00000382352.3 zinc finger, CCHC domain containing 3 1328 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

FBXL19 ENST00000338343.4 F-box and leucine-rich repeat protein 19 75 1 1 0 0 1 hsa-miR-5001-5p -0.12 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PPP1R26 ENST00000605286.1 protein phosphatase 1, regulatory subunit 26 7 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

NCOR2 ENST00000405201.1 nuclear receptor corepressor 2 200 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

CLSTN3 ENST00000266546.6 calsyntenin 3 5 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

PGAM5 ENST00000498926.2 phosphoglycerate mutase family member 5 2219 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.2 N/A

IGF1R ENST00000268035.6 insulin-like growth factor 1 receptor 561 2 0 2 0 2 hsa-miR-4498 -0.12 -0.12 N/A

ELL ENST00000262809.4 elongation factor RNA polymerase II 250 2 0 1 1 2 hsa-miR-5001-5p -0.12 -0.29 N/A

KMT2A ENST00000534358.1 lysine (K)-specific methyltransferase 2A 1092 2 0 1 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

FIGN ENST00000333129.3 fidgetin 10 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

SH2D7 ENST00000328828.5 SH2 domain containing 7 5 2 0 0 2 0 hsa-miR-5001-5p -0.12 -0.12 N/A

C6orf106 ENST00000374023.3 chromosome 6 open reading frame 106 80 2 1 0 1 3 hsa-miR-5001-5p -0.12 -0.33 N/A

CRKL ENST00000354336.3 v-crk avian sarcoma virus CT10 oncogene homolog-like 2142 1 0 0 1 2 hsa-miR-5001-5p -0.12 -0.12 N/A

FAM102A ENST00000373095.1 family with sequence similarity 102, member A 85 1 0 1 0 3 hsa-miR-5001-5p -0.12 -0.13 N/A

NDST4 ENST00000264363.2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 12 2 0 0 2 0 hsa-miR-5001-5p -0.12 -0.25 N/A

YPEL1 ENST00000339468.3 yippee-like 1 (Drosophila) 81 1 0 1 0 1 hsa-miR-4498 -0.12 -0.25 N/A

LHX5 ENST00000261731.3 LIM homeobox 5 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

FCRL5 ENST00000361835.3 Fc receptor-like 5 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

NUAK1 ENST00000261402.2 NUAK family, SNF1-like kinase, 1 489 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ST8SIA3 ENST00000324000.3 5 2 0 0 2 0 hsa-miR-5001-5p -0.12 -0.12 N/A 3 CDH3 ENST00000429102.2 cadherin 3, type 1, P-cadherin (placental) 21 1 0 0 1 1 hsa-miR-4498 -0.12 -0.12 N/A

CDC42EP4 ENST00000335793.3 CDC42 effector protein (Rho GTPase binding) 4 47 2 0 1 1 3 hsa-miR-4498 -0.12 -0.21 N/A

TMEM221 ENST00000341130.5 transmembrane protein 221 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

VEZF1 ENST00000584396.1 vascular endothelial zinc finger 1 209 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

SLFN12 ENST00000394562.1 schlafen family member 12 255 3 1 1 1 0 hsa-miR-5001-5p -0.12 -0.56 N/A

PLEKHA7 ENST00000531066.1 pleckstrin homology domain containing, family A member 7 40 1 0 1 0 0 hsa-miR-4498 -0.12 -0.14 N/A

TMED8 ENST00000216468.7 transmembrane emp24 protein transport domain containing 8 53 1 0 0 1 2 hsa-miR-5001-5p -0.12 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NLE1 ENST00000586869.1 notchless homolog 1 (Drosophila) 526 4 3 1 0 2 hsa-miR-4498 -0.12 -0.84 N/A

NPY4R ENST00000374312.1 neuropeptide Y receptor Y4 10 1 1 0 0 1 hsa-miR-4498 -0.12 -0.24 N/A

SMS ENST00000404933.2 spermine synthase 14 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.19 N/A

LRRC55 ENST00000497933.1 leucine rich repeat containing 55 5 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

ACSBG1 ENST00000258873.4 acyl-CoA synthetase bubblegum family member 1 5 1 1 0 0 1 hsa-miR-5001-5p -0.12 -0.12 N/A transcription elongation factor A (SII) N-terminal and TCEANC ENST00000380600.1 21 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A central domain containing CNR2 ENST00000374472.4 cannabinoid receptor 2 (macrophage) 5 1 0 1 0 0 hsa-miR-5001-5p -0.12 -0.12 N/A

EPHB4 ENST00000360620.3 EPH receptor B4 350 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

DIEXF ENST00000491415.2 digestive organ expansion factor homolog (zebrafish) 493 1 0 1 0 2 hsa-miR-4498 -0.12 -0.17 N/A

QKI ENST00000392127.2 QKI, KH domain containing, RNA binding 323 2 0 0 2 1 hsa-miR-5001-5p -0.12 -0.15 N/A

TBCK ENST00000273980.5 TBC1 domain containing kinase 20 1 1 0 0 0 hsa-miR-5001-5p -0.12 -0.17 N/A

ATP9A ENST00000311637.5 ATPase, class II, type 9A 1511 2 0 2 0 0 hsa-miR-4498 -0.12 -0.13 N/A

ANO10 ENST00000414522.2 anoctamin 10 330 1 0 1 0 1 hsa-miR-4498 -0.12 -0.15 N/A

GHR ENST00000230882.4 growth hormone receptor 102 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

MIP ENST00000257979.4 major intrinsic protein of lens fiber 5 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

TPBGL ENST00000562197.2 trophoblast glycoprotein-like 8 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

SNRNP200 ENST00000323853.5 small nuclear ribonucleoprotein 200kDa (U5) 256 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.13 N/A

ISCU ENST00000338291.4 iron-sulfur cluster assembly enzyme 182 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.26 N/A

RPL28 ENST00000560583.1 ribosomal protein L28 5407 5 1 2 2 3 hsa-miR-5001-5p -0.12 -1.08 N/A

FBXL2 ENST00000484457.1 F-box and leucine-rich repeat protein 2 12 1 1 0 0 0 hsa-miR-4498 -0.12 -0.3 N/A

GINS1 ENST00000429262.2 GINS complex subunit 1 (Psf1 homolog) 56 1 0 1 0 0 hsa-miR-4498 -0.12 -0.14 N/A Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, EFNA3 ENST00000505139.1 9 1 0 1 0 0 hsa-miR-4498 -0.12 -0.29 N/A highly similar to Ephrin-A3 membrane protein, palmitoylated 2 (MAGUK p55 subfamily MPP2 ENST00000377184.3 78 2 0 1 1 3 hsa-miR-4498 -0.12 -0.17 N/A member 2) GABRR1 ENST00000454853.2 gamma-aminobutyric acid (GABA) A receptor, rho 1 14 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.15 N/A

TET2 ENST00000545826.1 tet methylcytosine dioxygenase 2 558 1 0 1 0 3 hsa-miR-4498 -0.12 -0.12 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FOXN3 ENST00000345097.4 forkhead box N3 42 4 1 2 1 2 hsa-miR-5001-5p -0.12 -0.3 N/A

COL4A6 ENST00000334504.7 collagen, type IV, alpha 6 37 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A pleckstrin homology domain containing, family G (with PLEKHG4 ENST00000450733.1 276 1 0 1 0 0 hsa-miR-762 -0.12 -0.12 N/A RhoGef domain) member 4 phosphoinositide-interacting regulator of transient receptor PIRT ENST00000580256.2 5 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A potential channels TMEM25 ENST00000411589.2 transmembrane protein 25 767 1 0 1 0 0 hsa-miR-5001-5p -0.12 -0.12 N/A

RBM20 ENST00000369519.3 RNA binding motif protein 20 7 2 1 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

LANCL3 ENST00000378621.3 LanC lantibiotic synthetase component C-like 3 (bacterial) 15 3 0 0 3 0 hsa-miR-5001-5p -0.12 -0.18 N/A

DENND1A ENST00000373624.2 DENN/MADD domain containing 1A 2794 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

FAM96A ENST00000557835.1 family with sequence similarity 96, member A 191 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

GDF5OS ENST00000374375.1 growth differentiation factor 5 opposite strand 122 4 1 1 2 1 hsa-miR-4498 -0.12 -1.21 N/A

WDPCP ENST00000272321.7 WD repeat containing planar cell polarity effector 92 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.16 N/A golgi-associated, gamma adaptin ear containing, ARF GGA2 ENST00000309859.4 645 1 0 1 0 1 hsa-miR-4498 -0.12 -0.16 N/A binding protein 2 solute carrier family 36 (proton/amino acid symporter), SLC36A4 ENST00000326402.4 252 1 0 1 0 0 hsa-miR-5001-5p -0.12 -0.18 N/A member 4 ONECUT2 ENST00000491143.2 one cut homeobox 2 847 3 1 1 1 1 hsa-miR-5001-5p -0.12 -0.16 N/A

TMEM51 ENST00000434578.2 transmembrane protein 51 87 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

FMO2 ENST00000441535.1 flavin containing monooxygenase 2 (non-functional) 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

VPS9D1 ENST00000561976.1 VPS9 domain containing 1 23 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A tissue factor pathway inhibitor (lipoprotein-associated TFPI ENST00000392365.1 10747 1 0 1 0 0 hsa-miR-4498 -0.12 -0.13 N/A coagulation inhibitor) EREG ENST00000244869.2 epiregulin 5 1 0 0 1 0 hsa-miR-5001-5p -0.12 -0.12 N/A

MAP3K10 ENST00000253055.3 mitogen-activated protein kinase kinase kinase 10 178 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

C1orf229 ENST00000408893.2 chromosome 1 open reading frame 229 5 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

TNR ENST00000367674.2 tenascin R 5 1 0 1 0 2 hsa-miR-4498 -0.12 -0.12 N/A

GPRIN2 ENST00000374314.4 G protein regulated inducer of neurite outgrowth 2 5 1 0 0 1 2 hsa-miR-5001-5p -0.12 -0.12 N/A

FAM131B ENST00000443739.2 family with sequence similarity 131, member B 5 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

TMED7-TICAM2 ENST00000333314.3 TMED7-TICAM2 readthrough 202 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GBX2 ENST00000551105.1 gastrulation brain homeobox 2 53 3 0 1 2 3 hsa-miR-5001-5p -0.12 -0.5 N/A

ZNF259 ENST00000227322.3 zinc finger protein 259 265 2 0 1 1 0 hsa-miR-4498 -0.12 -0.23 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ11 ENST00000339994.4 282 1 0 1 0 1 hsa-miR-5001-5p -0.12 -0.12 N/A 11 TRIM14 ENST00000341469.2 tripartite motif containing 14 44 1 0 1 0 1 hsa-miR-4498 -0.12 -0.12 N/A

SIDT2 ENST00000324225.4 SID1 transmembrane family, member 2 341 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

GPR155 ENST00000392552.2 G protein-coupled receptor 155 11 2 0 1 1 0 hsa-miR-4498 -0.12 -0.12 N/A

NMUR1 ENST00000305141.4 neuromedin U receptor 1 5 1 0 0 1 1 hsa-miR-5001-5p -0.12 -0.12 N/A

FRMPD4 ENST00000380682.1 FERM and PDZ domain containing 4 25 2 0 0 2 0 hsa-miR-5001-5p -0.12 -0.12 N/A

NETO2 ENST00000562435.1 neuropilin (NRP) and tolloid (TLL)-like 2 723 3 1 0 2 0 hsa-miR-5001-5p -0.12 -0.29 N/A

TREML2 ENST00000483722.1 triggering receptor expressed on myeloid cells-like 2 5 1 0 0 1 1 hsa-miR-4498 -0.12 -0.12 N/A

ABCA2 ENST00000341511.6 ATP-binding cassette, sub-family A (ABC1), member 2 125 1 0 1 0 0 hsa-miR-4498 -0.12 -0.12 N/A

LEMD2 ENST00000293760.5 LEM domain containing 2 208 1 0 0 1 2 hsa-miR-5001-5p -0.12 -0.12 N/A feline leukemia virus subgroup C cellular receptor family, FLVCR2 ENST00000238667.4 29 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.14 N/A member 2 WDR77 ENST00000235090.5 WD repeat domain 77 1214 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.13 N/A

TICAM2 ENST00000408996.4 toll-like receptor adaptor molecule 2 202 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.16 N/A

SNAP29 ENST00000215730.7 synaptosomal-associated protein, 29kDa 766 1 0 1 0 0 hsa-miR-5001-5p -0.11 -0.24 N/A

IFNAR2 ENST00000404220.3 interferon (alpha, beta and omega) receptor 2 470 2 0 2 0 1 hsa-miR-4498 -0.11 -0.26 N/A

ZNF14 ENST00000344099.3 zinc finger protein 14 37 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.26 N/A

ERMN ENST00000410096.1 ermin, ERM-like protein 5 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

UGT2B7 ENST00000508661.1 UDP glucuronosyltransferase 2 family, polypeptide B7 5 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

TNFAIP3 ENST00000237289.4 tumor necrosis factor, alpha-induced protein 3 150 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

FAM154B ENST00000339465.5 family with sequence similarity 154, member B 7 1 0 1 0 0 hsa-miR-4498 -0.11 -0.11 N/A

TBRG1 ENST00000441174.3 transforming growth factor beta regulator 1 275 2 0 1 1 0 hsa-miR-5001-5p -0.11 -0.37 N/A

SETBP1 ENST00000282030.5 SET binding protein 1 77 2 0 0 2 0 hsa-miR-5001-5p -0.11 -0.14 N/A

CUX2 ENST00000261726.6 cut-like homeobox 2 15 1 1 0 0 0 hsa-miR-5001-5p -0.11 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PCYOX1 ENST00000264441.5 prenylcysteine oxidase 1 407 1 0 0 1 0 hsa-miR-4498 -0.11 -0.12 N/A

STRIP1 ENST00000369795.3 striatin interacting protein 1 114 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.14 N/A nuclear factor of activated T-cells, cytoplasmic, calcineurin- NFATC1 ENST00000253506.5 74 1 0 1 0 1 hsa-miR-4498 -0.11 -0.11 N/A dependent 1 DLG2 ENST00000398309.2 discs, large homolog 2 (Drosophila) 15 3 0 2 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

OLFM1 ENST00000371796.3 olfactomedin 1 610 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

TRAPPC3L ENST00000356128.4 trafficking protein particle complex 3-like 5 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

UNC119B ENST00000344651.4 unc-119 homolog B (C. elegans) 5 1 0 1 0 1 hsa-miR-5001-5p -0.11 -0.11 N/A

PGAP2 ENST00000396993.4 post-GPI attachment to proteins 2 595 1 0 0 1 0 hsa-miR-4498 -0.11 -0.11 N/A

KIF5A ENST00000455537.2 kinesin family member 5A 5 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

NUTM2E ENST00000602967.1 NUT family member 2E 5 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.11 N/A

LIMD1 ENST00000273317.4 LIM domains containing 1 1092 3 0 2 1 1 hsa-miR-5001-5p -0.11 -0.24 N/A

RAD54L2 ENST00000409535.2 RAD54-like 2 (S. cerevisiae) 215 3 2 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

AC007040.11 ENST00000606025.1 12 2 0 1 1 2 hsa-miR-5001-5p -0.11 -0.29 N/A

TTPAL ENST00000372906.2 tocopherol (alpha) transfer protein-like 265 1 0 1 0 1 hsa-miR-4498 -0.11 -0.17 N/A

FGF22 ENST00000215530.5 fibroblast growth factor 22 8 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.3 N/A

SH3BP2 ENST00000356331.5 SH3-domain binding protein 2 449 4 1 1 2 2 hsa-miR-5001-5p -0.11 -0.38 N/A

CAMKK1 ENST00000381769.2 calcium/calmodulin-dependent protein kinase kinase 1, alpha 34 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.11 N/A

MICALL1 ENST00000215957.6 MICAL-like 1 374 1 0 1 0 2 hsa-miR-4498 -0.11 -0.11 N/A

RNF8 ENST00000373479.4 ring finger protein 8, E3 ubiquitin protein ligase 301 1 0 1 0 1 hsa-miR-4498 -0.11 -0.11 N/A

HNF4A ENST00000316099.4 hepatocyte nuclear factor 4, alpha 915 2 0 1 1 0 hsa-miR-5001-5p -0.11 -0.19 N/A

TMPRSS2 ENST00000332149.5 transmembrane protease, serine 2 11 1 0 1 0 1 hsa-miR-4498 -0.11 -0.16 N/A

FOXP4 ENST00000373063.3 forkhead box P4 228 2 0 2 0 4 hsa-miR-5001-5p -0.11 -0.42 N/A

CHURC1-FNTB ENST00000549987.1 CHURC1-FNTB readthrough 13 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.19 N/A

RNF43 ENST00000407977.2 ring finger protein 43 52 2 0 1 1 0 hsa-miR-4498 -0.11 -0.25 N/A

SEC61A1 ENST00000243253.3 Sec61 alpha 1 subunit (S. cerevisiae) 2966 1 1 0 0 1 hsa-miR-5001-5p -0.11 -0.12 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SLC25A51 ENST00000380590.3 solute carrier family 25, member 51 170 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.12 N/A

NTNG2 ENST00000393229.3 netrin G2 15 2 0 2 0 0 hsa-miR-4498 -0.11 -0.35 N/A

PAPOLG ENST00000238714.3 poly(A) polymerase gamma 49 1 0 1 0 0 hsa-miR-4498 -0.11 -0.17 N/A

ZKSCAN2 ENST00000328086.7 zinc finger with KRAB and SCAN domains 2 81 2 0 0 2 1 hsa-miR-5001-5p -0.11 -0.12 N/A

CDKL1 ENST00000395834.1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 90 1 0 1 0 0 hsa-miR-4498 -0.11 -0.12 N/A

ADCYAP1 ENST00000579794.1 adenylate cyclase activating polypeptide 1 (pituitary) 35 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.26 N/A

PCGF3 ENST00000362003.5 polycomb group ring finger 3 503 3 1 2 0 0 hsa-miR-5001-5p -0.11 -0.53 N/A

SCAMP2 ENST00000268099.9 secretory carrier membrane protein 2 101 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.12 N/A

ULK1 ENST00000321867.4 unc-51 like autophagy activating kinase 1 3083 1 0 1 0 3 hsa-miR-4498 -0.11 -0.11 N/A

MEGF11 ENST00000360698.4 multiple EGF-like-domains 11 7 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.11 N/A

SCN5A ENST00000414099.2 sodium channel, voltage-gated, type V, alpha subunit 5 2 1 1 0 3 hsa-miR-5001-5p -0.11 -0.11 N/A

TM4SF18 ENST00000296059.2 transmembrane 4 L six family member 18 5 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.11 N/A

SRGAP3 ENST00000383836.3 SLIT-ROBO Rho GTPase activating protein 3 38 4 0 3 1 1 hsa-miR-5001-5p -0.11 -0.43 N/A

ZNF585B ENST00000532828.2 zinc finger protein 585B 46 1 0 1 0 0 hsa-miR-4498 -0.11 -0.17 N/A

PPP2R4 ENST00000393370.2 protein phosphatase 2A activator, regulatory subunit 4 2731 1 0 1 0 1 hsa-miR-4498 -0.11 -0.11 N/A

SLCO2A1 ENST00000310926.4 solute carrier organic anion transporter family, member 2A1 113 1 0 1 0 1 hsa-miR-4498 -0.11 -0.12 N/A

TTC19 ENST00000261647.5 tetratricopeptide repeat domain 19 64 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.12 N/A

C20orf144 ENST00000375222.3 chromosome 20 open reading frame 144 10 1 0 0 1 3 hsa-miR-5001-5p -0.11 -0.23 N/A

DOK4 ENST00000566936.1 docking protein 4 183 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.16 N/A

KLF8 ENST00000468660.1 Kruppel-like factor 8 8 2 0 0 2 0 hsa-miR-5001-5p -0.11 -0.17 N/A

COL25A1 ENST00000399132.1 collagen, type XXV, alpha 1 270 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.14 N/A ATPase, aminophospholipid transporter (APLT), class I, ATP8A1 ENST00000381668.5 48 1 1 0 0 0 hsa-miR-5001-5p -0.11 -0.11 N/A type 8A, member 1 MBNL3 ENST00000370839.3 muscleblind-like splicing regulator 3 593 2 0 0 2 0 hsa-miR-5001-5p -0.11 -0.17 N/A Homo sapiens putative uncharacterized protein FLJ37770- RP11-111M22.2 ENST00000530460.1 18 1 0 1 0 0 hsa-miR-4498 -0.11 -0.19 N/A like (LOC100506127), mRNA. SRGAP1 ENST00000355086.3 SLIT-ROBO Rho GTPase activating protein 1 64 2 0 0 2 1 hsa-miR-5001-5p -0.11 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RCOR1 ENST00000262241.6 REST corepressor 1 403 1 0 1 0 0 hsa-miR-4498 -0.11 -0.14 N/A

SLC5A3 ENST00000608209.1 sodium/myo-inositol cotransporter 24 1 0 1 0 0 hsa-miR-4498 -0.11 -0.15 N/A

ARRB1 ENST00000420843.2 arrestin, beta 1 598 7 0 7 0 1 hsa-miR-4498 -0.11 -0.58 N/A

NEBL ENST00000377122.4 nebulette 181 1 0 1 0 0 hsa-miR-4498 -0.11 -0.11 N/A

ZNF740 ENST00000416904.3 zinc finger protein 740 2137 1 0 1 0 1 hsa-miR-4498 -0.11 -0.11 N/A

RIC3 ENST00000396677.2 RIC3 acetylcholine receptor chaperone 5 1 0 1 0 1 hsa-miR-4498 -0.11 -0.11 N/A translocase of outer mitochondrial membrane 40 homolog TOMM40 ENST00000592434.1 14 1 0 1 0 0 hsa-miR-4498 -0.11 -0.11 N/A (yeast) FUOM ENST00000278025.4 fucose mutarotase 1270 1 0 0 1 0 hsa-miR-4498 -0.11 -0.11 N/A

CD4 ENST00000011653.4 CD4 molecule 5 1 0 1 0 2 hsa-miR-4498 -0.11 -0.11 N/A

USP13 ENST00000263966.3 ubiquitin specific peptidase 13 (isopeptidase T-3) 379 2 0 2 0 2 hsa-miR-4498 -0.11 -0.16 N/A

PTPLAD1 ENST00000261875.5 protein tyrosine phosphatase-like A domain containing 1 11697 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.12 N/A

NCEH1 ENST00000475381.1 neutral cholesterol ester hydrolase 1 1779 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

SF3A1 ENST00000215793.8 splicing factor 3a, subunit 1, 120kDa 1091 2 0 0 2 0 hsa-miR-5001-5p -0.11 -0.27 N/A

ATF7IP2 ENST00000396559.1 activating transcription factor 7 interacting protein 2 50 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.11 N/A

ADAM12 ENST00000368679.4 ADAM metallopeptidase domain 12 758 2 0 1 1 0 hsa-miR-4498 -0.11 -0.12 N/A

FAR1 ENST00000354817.3 fatty acyl CoA reductase 1 814 1 0 1 0 0 hsa-miR-5001-5p -0.11 -0.14 N/A

PHACTR1 ENST00000379350.1 phosphatase and actin regulator 1 5 1 0 1 0 3 hsa-miR-4498 -0.11 -0.11 N/A potassium voltage-gated channel, delayed-rectifier, KCNS2 ENST00000287042.4 5 3 0 2 1 0 hsa-miR-4498 -0.11 -0.11 N/A subfamily S, member 2 SLC4A3 ENST00000273063.6 solute carrier family 4 (anion exchanger), member 3 32 1 0 1 0 0 hsa-miR-4498 -0.11 -0.11 N/A

P2RY11 ENST00000321826.4 purinergic receptor P2Y, G-protein coupled, 11 293 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

IL7R ENST00000343305.4 interleukin 7 receptor 293 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic PIK3CD ENST00000536656.1 5 2 0 1 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A subunit delta mannosyl (beta-1,4-)-glycoprotein beta-1,4-N- MGAT3 ENST00000341184.6 9 2 0 1 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A acetylglucosaminyltransferase ZBTB8B ENST00000609129.1 zinc finger and BTB domain containing 8B 18 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.22 N/A

FANCB ENST00000324138.3 Fanconi anemia, complementation group B 54 1 1 0 0 1 hsa-miR-5001-5p -0.11 -0.44 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FAM47E ENST00000515604.1 Protein FAM47E 503 1 0 0 1 1 hsa-miR-4498 -0.11 -0.14 N/A

ILDR2 ENST00000469934.2 immunoglobulin-like domain containing receptor 2 7 1 1 0 0 2 hsa-miR-5001-5p -0.11 -0.38 N/A calcium channel, voltage-dependent, P/Q type, alpha 1A CACNA1A ENST00000573710.2 5 2 0 2 0 0 hsa-miR-4498 -0.11 -0.18 N/A subunit KIAA1147 ENST00000536163.1 KIAA1147 73 1 0 1 0 2 hsa-miR-4498 -0.11 -0.16 N/A

LRRD1 ENST00000343318.5 leucine-rich repeats and death domain containing 1 9 1 1 0 0 1 hsa-miR-5001-5p -0.11 -0.26 N/A

AHRR ENST00000316418.5 aryl-hydrocarbon receptor repressor 1049 1 0 0 1 2 hsa-miR-5001-5p -0.11 -0.13 N/A

HDGFRP2 ENST00000301284.4 Hepatoma-derived growth factor-related protein 2 182 1 0 1 0 0 hsa-miR-4498 -0.11 -0.11 N/A

GSG1L ENST00000380898.2 GSG1-like 5 1 0 1 0 1 hsa-miR-5001-5p -0.11 -0.11 N/A

NKX6-3 ENST00000524115.2 NK6 homeobox 3 5 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.11 N/A

LIME1 ENST00000309546.3 Lck interacting transmembrane adaptor 1 252 1 0 1 0 0 hsa-miR-5001-5p -0.11 -0.11 N/A

FADS6 ENST00000310226.6 fatty acid desaturase 6 12 2 1 0 1 1 hsa-miR-5001-5p -0.11 -0.28 N/A

TMEM194B ENST00000409150.3 transmembrane protein 194B 271 1 0 1 0 0 hsa-miR-4498 -0.11 -0.23 N/A

EHD4 ENST00000220325.4 EH-domain containing 4 515 2 0 2 0 1 hsa-miR-5001-5p -0.11 -0.27 N/A

PP13439 ENST00000331659.2 289 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

CTU1 ENST00000421832.2 cytosolic thiouridylase subunit 1 170 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.11 N/A

DAAM2 ENST00000538976.1 dishevelled associated activator of morphogenesis 2 5 1 0 0 1 2 hsa-miR-4498 -0.11 -0.11 N/A

C1orf213 ENST00000335648.3 chromosome 1 open reading frame 213 49 1 0 0 1 0 hsa-miR-4498 -0.11 -0.11 N/A

SRPX2 ENST00000373004.3 sushi-repeat containing protein, X-linked 2 69 1 1 0 0 1 hsa-miR-5001-5p -0.11 -0.18 N/A

TMX3 ENST00000299608.2 thioredoxin-related transmembrane protein 3 348 1 0 0 1 1 hsa-miR-5001-5p -0.11 -0.12 N/A

ABHD6 ENST00000295962.4 abhydrolase domain containing 6 289 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

GAB1 ENST00000262995.4 GRB2-associated binding protein 1 26 3 1 1 1 0 hsa-miR-4498 -0.11 -0.65 N/A

UPB1 ENST00000413389.2 ureidopropionase, beta 26 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.12 N/A

LOH12CR1 ENST00000314565.4 loss of heterozygosity, 12, chromosomal region 1 135 1 0 1 0 0 hsa-miR-4498 -0.11 -0.23 N/A

FBXW11 ENST00000296933.6 F-box and WD repeat domain containing 11 81 1 0 0 1 0 hsa-miR-5001-5p -0.11 -0.11 N/A

TBC1D14 ENST00000448507.1 TBC1 domain family, member 14 1583 2 0 1 1 1 hsa-miR-4498 -0.11 -0.11 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SSTR3 ENST00000328544.3 somatostatin receptor 3 5 1 1 0 0 1 hsa-miR-5001-5p -0.1 -0.1 N/A

MBTD1 ENST00000586178.1 mbt domain containing 1 113 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

LRRC56 ENST00000270115.7 leucine rich repeat containing 56 60 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.1 N/A

SOX8 ENST00000293894.3 SRY (sex determining region Y)-box 8 5 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

AL953854.2 ENST00000438517.1 5 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A

ARSE ENST00000540563.1 arylsulfatase E (chondrodysplasia punctata 1) 42 1 0 1 0 0 hsa-miR-4498 -0.1 -0.12 N/A

SLK ENST00000335753.4 STE20-like kinase 260 1 1 0 0 0 hsa-miR-4498 -0.1 -0.15 N/A

TRAF2 ENST00000247668.2 TNF receptor-associated factor 2 101 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.17 N/A

TPCN1 ENST00000335509.6 two pore segment channel 1 401 1 0 1 0 3 hsa-miR-4498 -0.1 -0.1 N/A

ARRDC4 ENST00000268042.6 arrestin domain containing 4 10 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

GPR63 ENST00000229955.3 G protein-coupled receptor 63 5 1 0 0 1 0 hsa-miR-4498 -0.1 -0.1 N/A

FRMD1 ENST00000283309.6 FERM domain containing 1 5 1 0 0 1 2 hsa-miR-5001-5p -0.1 -0.1 N/A

WNT7A ENST00000285018.4 wingless-type MMTV integration site family, member 7A 5 1 0 0 1 1 hsa-miR-762 -0.1 -0.1 N/A

CEP41 ENST00000223208.5 centrosomal protein 41kDa 346 1 0 0 1 0 hsa-miR-4498 -0.1 -0.15 N/A

MYSM1 ENST00000472487.1 Myb-like, SWIRM and MPN domains 1 38 1 0 0 1 1 hsa-miR-4498 -0.1 -0.15 N/A

HIF1AN ENST00000299163.6 hypoxia inducible factor 1, alpha subunit inhibitor 1545 4 3 0 1 2 hsa-miR-5001-5p -0.1 -0.37 N/A

ATP11A ENST00000487903.1 ATPase, class VI, type 11A 731 2 1 1 0 3 hsa-miR-5001-5p -0.1 -0.11 N/A

RANGAP1 ENST00000405486.1 Ran GTPase activating protein 1 2648 2 0 1 1 1 hsa-miR-5001-5p -0.1 -0.13 N/A

ASAP2 ENST00000315273.4 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 38 1 0 0 1 0 hsa-miR-4498 -0.1 -0.1 N/A

RBM3 ENST00000354480.2 RNA binding motif (RNP1, RRM) protein 3 1325 2 1 0 1 0 hsa-miR-5001-5p -0.1 -0.63 N/A

NBPF3 ENST00000318220.6 neuroblastoma breakpoint family, member 3 5 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

AGPAT4 ENST00000366911.5 1-acylglycerol-3-phosphate O-acyltransferase 4 142 1 1 0 0 3 hsa-miR-5001-5p -0.1 -0.2 N/A

SP2 ENST00000376741.4 Sp2 transcription factor 779 2 0 2 0 2 hsa-miR-4498 -0.1 -0.16 N/A

PSEN1 ENST00000344094.3 presenilin 1 1340 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.16 N/A

MYO9A ENST00000564571.1 myosin IXA 137 2 0 2 0 3 hsa-miR-4498 -0.1 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score STK25 ENST00000316586.4 serine/threonine kinase 25 699 2 0 1 1 4 hsa-miR-5001-5p -0.1 -0.37 N/A

METTL16 ENST00000263092.6 methyltransferase like 16 8 1 1 0 0 0 hsa-miR-5001-5p -0.1 -0.17 N/A XK, Kell blood group complex subunit-related family, XKR4 ENST00000327381.6 5 2 1 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A member 4 TELO2 ENST00000262319.6 telomere maintenance 2 206 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

FBXO24 ENST00000360609.2 F-box protein 24 19 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

CLTCL1 ENST00000353891.5 clathrin, heavy chain-like 1 89 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

TNFRSF19 ENST00000382263.3 tumor necrosis factor receptor superfamily, member 19 376 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

DNAJC11 ENST00000377577.5 DnaJ (Hsp40) homolog, subfamily C, member 11 361 1 1 0 0 2 hsa-miR-5001-5p -0.1 -0.18 N/A

BEND4 ENST00000504360.1 BEN domain containing 4 187 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.1 N/A

HECTD3 ENST00000372168.3 HECT domain containing E3 ubiquitin protein ligase 3 45 1 0 1 0 2 hsa-miR-4498 -0.1 -0.12 N/A

FKTN ENST00000223528.2 fukutin 153 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

PDE7B ENST00000308191.6 phosphodiesterase 7B 148 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

CHL1 ENST00000256509.2 cell adhesion molecule L1-like 24 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.1 N/A

C8orf86 ENST00000358138.1 chromosome 8 open reading frame 86 5 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

CLHC1 ENST00000406437.2 clathrin heavy chain linker domain containing 1 21 1 0 1 0 0 hsa-miR-4498 -0.1 -0.17 N/A

KCTD17 ENST00000402077.3 potassium channel tetramerization domain containing 17 187 2 0 1 1 0 hsa-miR-4498 -0.1 -0.33 N/A

SIT1 ENST00000259608.3 signaling threshold regulating transmembrane adaptor 1 7 2 0 2 0 0 hsa-miR-4498 -0.1 -0.21 N/A

C17orf82 ENST00000335108.2 chromosome 17 open reading frame 82 10 2 0 0 2 1 hsa-miR-5001-5p -0.1 -0.22 N/A

EXTL1 ENST00000374280.3 exostosin-like glycosyltransferase 1 35 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.11 N/A

GPR135 ENST00000395116.1 G protein-coupled receptor 135 40 1 0 1 0 0 hsa-miR-4498 -0.1 -0.14 N/A

RNMT ENST00000383314.2 RNA (guanine-7-) methyltransferase 64 2 0 0 2 0 hsa-miR-5001-5p -0.1 -0.15 N/A

DUSP2 ENST00000288943.4 dual specificity phosphatase 2 41 2 0 2 0 0 hsa-miR-4498 -0.1 -0.3 N/A

SLAMF8 ENST00000289707.5 SLAM family member 8 5 1 0 0 1 2 hsa-miR-5001-5p -0.1 -0.1 N/A

GRB7 ENST00000309185.3 growth factor receptor-bound protein 7 66 1 0 0 1 2 hsa-miR-5001-5p -0.1 -0.1 N/A

GLDN ENST00000335449.6 gliomedin 9 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GLIS3 ENST00000324333.10 GLIS family zinc finger 3 47 1 0 0 1 3 hsa-miR-4498 -0.1 -0.1 N/A

WFS1 ENST00000226760.1 Wolfram syndrome 1 (wolframin) 3858 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

HGS ENST00000329138.4 hepatocyte growth factor-regulated tyrosine kinase substrate 83 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

TMEM135 ENST00000340353.7 transmembrane protein 135 963 2 0 1 1 0 hsa-miR-5001-5p -0.1 -0.26 N/A

C1orf198 ENST00000366663.5 chromosome 1 open reading frame 198 1484 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.12 N/A

ZNF641 ENST00000301042.3 zinc finger protein 641 87 2 1 0 1 0 hsa-miR-4498 -0.1 -0.24 N/A

SPATA17 ENST00000366933.4 spermatogenesis associated 17 12 2 0 1 1 1 hsa-miR-5001-5p -0.1 -0.25 N/A

C20orf26 ENST00000377309.2 chromosome 20 open reading frame 26 5 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

CSF1 ENST00000329608.6 colony stimulating factor 1 (macrophage) 290 1 0 1 0 2 hsa-miR-4498 -0.1 -0.1 N/A

PPP6R1 ENST00000412770.2 protein phosphatase 6, regulatory subunit 1 292 1 0 1 0 1 hsa-miR-5001-5p -0.1 -0.12 N/A

F9 ENST00000218099.2 coagulation factor IX 5 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

XK ENST00000378616.3 X-linked Kx blood group (McLeod syndrome) 39 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

SPHKAP ENST00000392056.3 SPHK1 interactor, AKAP domain containing 5 2 0 1 1 0 hsa-miR-4498 -0.1 -0.1 N/A

RNF41 ENST00000345093.4 ring finger protein 41 152 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

DPF2 ENST00000528416.1 D4, zinc and double PHD fingers family 2 1164 1 0 1 0 2 hsa-miR-4498 -0.1 -0.1 N/A

TRDMT1 ENST00000377799.3 tRNA aspartic acid methyltransferase 1 248 2 1 0 1 0 hsa-miR-5001-5p -0.1 -0.44 N/A

GTF3C4 ENST00000372146.4 general transcription factor IIIC, polypeptide 4, 90kDa 1598 1 0 1 0 1 hsa-miR-4498 -0.1 -0.11 N/A

STX18 ENST00000306200.2 syntaxin 18 76 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.13 N/A

ZXDB ENST00000374888.1 zinc finger, X-linked, duplicated B 33 1 0 1 0 1 hsa-miR-4498 -0.1 -0.21 N/A

SDAD1 ENST00000356260.5 SDA1 domain containing 1 91 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.17 N/A

CPNE3 ENST00000198765.4 copine III 756 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A solute carrier family 6 (neurotransmitter transporter), SLC6A11 ENST00000254488.2 83 1 0 1 0 2 hsa-miR-4498 -0.1 -0.13 N/A member 11 PTOV1 ENST00000391842.1 prostate tumor overexpressed 1 9 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A pleckstrin homology domain containing, family H (with PLEKHH1 ENST00000329153.5 125 1 1 0 0 2 hsa-miR-5001-5p -0.1 -0.1 N/A MyTH4 domain) member 1 GRIN3A ENST00000361820.3 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 5 1 0 1 0 1 hsa-miR-4498 -0.1 -0.1 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score C12orf68 ENST00000316554.3 chromosome 12 open reading frame 68 5 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A

CRELD1 ENST00000326434.5 cysteine-rich with EGF-like domains 1 185 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

RUNX2 ENST00000371432.3 runt-related transcription factor 2 105 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

MME ENST00000460393.1 membrane metallo-endopeptidase 37 1 0 1 0 1 hsa-miR-4498 -0.1 -0.25 N/A

PROB1 ENST00000434752.2 proline-rich basic protein 1 126 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

ALDH1L2 ENST00000258494.9 aldehyde dehydrogenase 1 family, member L2 22 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.16 N/A

DCPS ENST00000263579.4 decapping enzyme, scavenger 320 5 0 4 1 3 hsa-miR-5001-5p -0.1 -0.36 N/A

EN2 ENST00000297375.4 engrailed homeobox 2 86 2 0 0 2 0 hsa-miR-5001-5p -0.1 -0.16 N/A

CNKSR2 ENST00000379510.3 connector enhancer of kinase suppressor of Ras 2 85 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.11 N/A

ALDH1A2 ENST00000249750.4 aldehyde dehydrogenase 1 family, member A2 401 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

CHST8 ENST00000438847.3 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 32 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

MLH3 ENST00000355774.2 mutL homolog 3 152 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

GCM1 ENST00000259803.7 glial cells missing homolog 1 (Drosophila) 5 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

FAM53C ENST00000513056.1 family with sequence similarity 53, member C 592 1 0 1 0 4 hsa-miR-5001-5p -0.1 -0.29 N/A

ZNF398 ENST00000420008.2 zinc finger protein 398 305 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.15 N/A extracellular leucine-rich repeat and fibronectin type III ELFN2 ENST00000402918.2 22 3 2 1 0 3 hsa-miR-5001-5p -0.1 -0.31 N/A domain containing 2 MAN1B1 ENST00000371589.4 mannosidase, alpha, class 1B, member 1 604 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

AGR2 ENST00000419304.2 anterior gradient 2 13 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.26 N/A

ING1 ENST00000333219.7 inhibitor of growth family, member 1 142 2 0 1 1 0 hsa-miR-4498 -0.1 -0.29 N/A

ADAM11 ENST00000200557.6 ADAM metallopeptidase domain 11 32 1 0 1 0 0 hsa-miR-4498 -0.1 -0.14 N/A

TMEM110 ENST00000355083.5 transmembrane protein 110 306 2 0 1 1 1 hsa-miR-4498 -0.1 -0.19 N/A

ZNF7 ENST00000528372.1 zinc finger protein 7 129 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.12 N/A

GMPPB ENST00000480687.1 GDP-mannose pyrophosphorylase B 425 3 1 2 0 0 hsa-miR-4498 -0.1 -0.55 N/A

UBQLN4 ENST00000368309.3 ubiquilin 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.1 N/A

NLRC5 ENST00000436936.1 NLR family, CARD domain containing 5 47 1 0 1 0 1 hsa-miR-4498 -0.1 -0.1 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PDPN ENST00000294489.6 podoplanin 264 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.18 N/A

POLK ENST00000241436.4 polymerase (DNA directed) kappa 294 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.12 N/A pleckstrin homology domain containing, family A PLEKHA8 ENST00000449726.1 661 1 0 0 1 0 hsa-miR-4498 -0.1 -0.1 N/A (phosphoinositide binding specific) member 8 ATP6V1C2 ENST00000381661.3 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 8 1 0 0 1 0 hsa-miR-5001-5p -0.1 -0.16 N/A

RP11-766F14.2 ENST00000511828.1 Protein LOC285556 5 1 0 1 0 0 hsa-miR-4498 -0.1 -0.1 N/A

SMAD9 ENST00000399275.2 SMAD family member 9 62 1 0 1 0 0 hsa-miR-5001-5p -0.1 -0.1 N/A

PLEK ENST00000234313.7 pleckstrin 5 1 0 0 1 1 hsa-miR-5001-5p -0.1 -0.1 N/A

RABIF ENST00000367262.3 RAB interacting factor 948 3 0 1 2 0 hsa-miR-4498 -0.09 -0.45 N/A

SLIT2 ENST00000504154.1 slit homolog 2 (Drosophila) 579 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.25 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS9 ENST00000295903.4 5 1 0 0 1 0 hsa-miR-4498 -0.09 -0.1 N/A 9 FGFR1 ENST00000397091.5 fibroblast growth factor receptor 1 650 1 0 1 0 1 hsa-miR-5001-5p -0.09 -0.1 N/A

FBRSL1 ENST00000434748.2 fibrosin-like 1 778 2 0 2 0 0 hsa-miR-4498 -0.09 -0.11 N/A ATPase, aminophospholipid transporter, class I, type 8A, ATP8A2 ENST00000381655.2 22 3 0 1 2 0 hsa-miR-4498 -0.09 -0.2 N/A member 2 DNAJC16 ENST00000375847.3 DnaJ (Hsp40) homolog, subfamily C, member 16 366 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.11 N/A

SHROOM2 ENST00000380913.3 shroom family member 2 121 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.1 N/A

FASTK ENST00000540185.1 Fas-activated serine/threonine kinase 645 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

MARCH9 ENST00000266643.5 membrane-associated ring finger (C3HC4) 9 328 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A

TSPYL2 ENST00000375442.4 TSPY-like 2 270 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

TMEM239 ENST00000361033.1 transmembrane protein 239 5 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.09 N/A

KLHL3 ENST00000541417.1 kelch-like family member 3 40 1 0 1 0 0 hsa-miR-4498 -0.09 -0.11 N/A

LOXL4 ENST00000260702.3 lysyl oxidase-like 4 299 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A potassium large conductance calcium-activated channel, KCNMB3 ENST00000497599.1 8 2 1 0 1 0 hsa-miR-4498 -0.09 -0.27 N/A subfamily M beta member 3 MROH6 ENST00000398882.3 maestro heat-like repeat family member 6 24 1 0 1 0 1 hsa-miR-4498 -0.09 -0.09 N/A

BTD ENST00000303498.5 biotinidase 183 2 1 1 0 3 hsa-miR-4498 -0.09 -0.12 N/A

FAM13A ENST00000395002.2 family with sequence similarity 13, member A 441 2 0 0 2 2 hsa-miR-5001-5p -0.09 -0.15 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CENPO ENST00000380834.2 centromere protein O 298 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.2 N/A

PHF7 ENST00000327906.3 PHD finger protein 7 38 1 0 1 0 0 hsa-miR-4498 -0.09 -0.17 N/A

NOTCH2 ENST00000256646.2 notch 2 734 1 0 1 0 1 hsa-miR-4498 -0.09 -0.1 N/A

CD81 ENST00000263645.5 CD81 molecule 14385 1 0 1 0 1 hsa-miR-5001-5p -0.09 -0.12 N/A

ZHX2 ENST00000314393.4 zinc fingers and homeoboxes 2 414 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

LARS2 ENST00000415258.1 leucyl-tRNA synthetase 2, mitochondrial 316 1 0 0 1 0 hsa-miR-762 -0.09 -0.09 N/A

KIAA0895L ENST00000561621.1 KIAA0895-like 15 1 0 1 0 0 hsa-miR-4498 -0.09 -0.22 N/A

UBAC2 ENST00000376440.2 UBA domain containing 2 902 2 0 1 1 1 hsa-miR-5001-5p -0.09 -0.1 N/A

AEN ENST00000332810.3 apoptosis enhancing nuclease 610 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

TRIM67 ENST00000444294.3 tripartite motif containing 67 41 2 0 0 2 2 hsa-miR-5001-5p -0.09 -0.11 N/A

AIFM2 ENST00000307864.1 apoptosis-inducing factor, mitochondrion-associated, 2 334 1 0 1 0 0 hsa-miR-4498 -0.09 -0.19 N/A

PRSS56 ENST00000449534.2 protease, serine, 56 5 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

HEY1 ENST00000354724.3 hairy/enhancer-of-split related with YRPW motif 1 33 1 0 1 0 0 hsa-miR-4498 -0.09 -0.29 N/A

CASP3 ENST00000393585.2 caspase 3, apoptosis-related cysteine peptidase 43 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.09 N/A

NCDN ENST00000356090.4 neurochondrin 654 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.09 N/A

SHOX ENST00000381578.1 short stature homeobox 5 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

ZNF710 ENST00000268154.4 zinc finger protein 710 5 2 0 2 0 0 hsa-miR-4498 -0.09 -0.09 N/A

PRPF4 ENST00000374199.4 pre-mRNA processing factor 4 2735 1 0 0 1 2 hsa-miR-4498 -0.09 -0.09 N/A

RPL27A ENST00000314138.6 ribosomal protein L27a 2641 2 0 0 2 0 hsa-miR-4498 -0.09 -0.23 N/A

RFX3 ENST00000382004.3 regulatory factor X, 3 (influences HLA class II expression) 37 1 0 1 0 0 hsa-miR-4498 -0.09 -0.13 N/A

PIP5K1C ENST00000335312.3 phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 13 3 0 1 2 4 hsa-miR-5001-5p -0.09 -0.09 N/A

EVI5 ENST00000370331.1 ecotropic viral integration site 5 172 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.11 N/A

C7orf50 ENST00000357429.6 chromosome 7 open reading frame 50 4161 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

FAXC ENST00000389677.5 failed axon connections homolog (Drosophila) 95 1 0 0 1 2 hsa-miR-4498 -0.09 -0.2 N/A

ZBTB11 ENST00000312938.4 zinc finger and BTB domain containing 11 179 1 0 0 1 1 hsa-miR-4498 -0.09 -0.09 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score EZR ENST00000337147.7 ezrin 3757 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A potassium voltage-gated channel, Isk-related family, member KCNE1 ENST00000399289.3 5 1 0 0 1 3 hsa-miR-5001-5p -0.09 -0.09 N/A 1 EIF4G1 ENST00000342981.4 eukaryotic translation initiation factor 4 gamma, 1 1027 1 0 1 0 0 hsa-miR-4498 -0.09 -0.15 N/A

FAM71F2 ENST00000480462.1 family with sequence similarity 71, member F2 7 1 0 1 0 1 hsa-miR-4498 -0.09 -0.31 N/A nuclear factor of activated T-cells, cytoplasmic, calcineurin- NFATC2IP ENST00000320805.4 754 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.11 N/A dependent 2 interacting protein OPRK1 ENST00000265572.3 opioid receptor, kappa 1 5 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A potassium voltage-gated channel, shaker-related subfamily, KCNA1 ENST00000382545.3 5 1 1 0 0 1 hsa-miR-5001-5p -0.09 -0.09 N/A member 1 (episodic ataxia with myokymia) FAXDC2 ENST00000326080.5 fatty acid hydroxylase domain containing 2 43 1 0 1 0 1 hsa-miR-4498 -0.09 -0.09 N/A

RASGRF2 ENST00000265080.4 Ras protein-specific guanine nucleotide-releasing factor 2 140 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.1 N/A

NCALD ENST00000395923.1 neurocalcin delta 49 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

SFMBT2 ENST00000361972.4 Scm-like with four mbt domains 2 107 1 0 0 1 0 hsa-miR-4498 -0.09 -0.09 N/A

CLEC2L ENST00000422142.2 C-type lectin domain family 2, member L 194 1 0 1 0 2 hsa-miR-4498 -0.09 -0.09 N/A

EMCN ENST00000296420.4 endomucin 5 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

ITCH ENST00000374864.4 itchy E3 ubiquitin protein ligase 769 2 0 2 0 0 hsa-miR-5001-5p -0.09 -0.22 N/A ectonucleotide pyrophosphatase/phosphodiesterase 4 ENPP4 ENST00000321037.4 114 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.1 N/A (putative) LSM14A ENST00000433627.5 LSM14A, SCD6 homolog A (S. cerevisiae) 362 1 0 1 0 0 hsa-miR-4498 -0.09 -0.25 N/A

C6orf223 ENST00000439969.2 chromosome 6 open reading frame 223 17 2 0 1 1 0 hsa-miR-4498 -0.09 -0.19 N/A

IRF1 ENST00000245414.4 interferon regulatory factor 1 266 2 0 1 1 1 hsa-miR-4498 -0.09 -0.49 N/A

BRPF3 ENST00000534400.1 bromodomain and PHD finger containing, 3 7032 1 1 0 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A

KIF21A ENST00000361961.3 kinesin family member 21A 37 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

CHST13 ENST00000319340.2 carbohydrate (chondroitin 4) sulfotransferase 13 1271 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.09 N/A

KIAA1199 ENST00000220244.3 KIAA1199 660 2 0 1 1 3 hsa-miR-5001-5p -0.09 -0.09 N/A

PDE4B ENST00000371045.5 phosphodiesterase 4B, cAMP-specific 127 1 1 0 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A

GPR151 ENST00000311104.2 G protein-coupled receptor 151 5 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

CFL1 ENST00000525451.2 cofilin 1 (non-muscle) 341 1 0 1 0 1 hsa-miR-5001-5p -0.09 -0.37 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score golgi-associated, gamma adaptin ear containing, ARF GGA3 ENST00000351904.7 14 1 0 1 0 2 hsa-miR-4498 -0.09 -0.11 N/A binding protein 3 ABI3 ENST00000225941.1 ABI family, member 3 12 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.22 N/A

CLSTN1 ENST00000377298.4 calsyntenin 1 1902 2 0 2 0 0 hsa-miR-4498 -0.09 -0.11 N/A

TCEA3 ENST00000450454.2 transcription elongation factor A (SII), 3 128 1 1 0 0 1 hsa-miR-5001-5p -0.09 -0.44 N/A

TMEM218 ENST00000532156.1 transmembrane protein 218 553 1 0 0 1 1 hsa-miR-4498 -0.09 -0.23 N/A

ZNF213 ENST00000396878.3 zinc finger protein 213 48 1 0 0 1 0 hsa-miR-4498 -0.09 -0.09 N/A

CACNA1I ENST00000402142.3 calcium channel, voltage-dependent, T type, alpha 1I subunit 5 3 1 2 0 2 hsa-miR-4498 -0.09 -0.09 N/A

ARID5B ENST00000279873.7 AT rich interactive domain 5B (MRF1-like) 397 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

MEX3C ENST00000592416.1 mex-3 RNA binding family member C 5 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

AP1S3 ENST00000396654.2 adaptor-related protein complex 1, sigma 3 subunit 130 1 0 1 0 1 hsa-miR-4498 -0.09 -0.19 N/A

PYGO2 ENST00000368457.2 pygopus homolog 2 (Drosophila) 35 1 1 0 0 0 hsa-miR-5001-5p -0.09 -0.39 N/A

RNF169 ENST00000299563.4 ring finger protein 169 204 1 0 1 0 0 hsa-miR-4498 -0.09 -0.1 N/A

PARP12 ENST00000263549.3 poly (ADP-ribose) polymerase family, member 12 16 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.1 N/A

ERN1 ENST00000433197.3 endoplasmic reticulum to nucleus signaling 1 182 2 1 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

PDK3 ENST00000441463.2 pyruvate dehydrogenase kinase, isozyme 3 659 1 0 1 0 1 hsa-miR-4498 -0.09 -0.15 N/A

INHBC ENST00000309668.2 inhibin, beta C 5 2 0 0 2 0 hsa-miR-5001-5p -0.09 -0.17 N/A

SYTL3 ENST00000367081.3 synaptotagmin-like 3 16 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.17 N/A

DRP2 ENST00000402866.1 dystrophin related protein 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.09 N/A

C21orf59 ENST00000382549.4 chromosome 21 open reading frame 59 288 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.09 N/A

VSTM4 ENST00000332853.4 V-set and transmembrane domain containing 4 59 1 0 1 0 2 hsa-miR-5001-5p -0.09 -0.09 N/A

ST14 ENST00000278742.5 suppression of tumorigenicity 14 (colon carcinoma) 11 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

PPAN ENST00000556468.1 peter pan homolog (Drosophila) 288 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

ZBTB5 ENST00000307750.4 zinc finger and BTB domain containing 5 281 1 0 0 1 1 hsa-miR-5001-5p -0.09 -0.1 N/A

TMEM63A ENST00000366835.3 transmembrane protein 63A 117 2 1 0 1 0 hsa-miR-5001-5p -0.09 -0.23 N/A

FMN1 ENST00000334528.9 formin 1 25 2 0 1 1 1 hsa-miR-5001-5p -0.09 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SREBF1 ENST00000395757.1 sterol regulatory element binding transcription factor 1 387 1 0 1 0 0 hsa-miR-4498 -0.09 -0.22 N/A

ARSI ENST00000328668.7 arylsulfatase family, member I 19 1 0 1 0 0 hsa-miR-4498 -0.09 -0.13 N/A

FLT1 ENST00000282397.4 fms-related tyrosine kinase 1 7 2 0 1 1 0 hsa-miR-4498 -0.09 -0.09 N/A

SENP7 ENST00000394095.2 SUMO1/sentrin specific peptidase 7 342 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

USP30 ENST00000257548.5 ubiquitin specific peptidase 30 76 3 0 1 2 1 hsa-miR-5001-5p -0.09 -0.33 N/A

HNF1A ENST00000257555.6 HNF1 homeobox A 377 1 0 1 0 0 hsa-miR-4498 -0.09 -0.09 N/A

SPATA2L ENST00000289805.5 spermatogenesis associated 2-like 10 1 0 0 1 2 hsa-miR-5001-5p -0.09 -0.09 N/A

SIK2 ENST00000304987.3 salt-inducible kinase 2 378 2 0 2 0 1 hsa-miR-4498 -0.09 -0.15 N/A

RGS17 ENST00000367225.2 regulator of G-protein signaling 17 11 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.15 N/A

SCAI ENST00000336505.6 suppressor of cancer cell invasion 74 2 0 1 1 1 hsa-miR-5001-5p -0.09 -0.2 N/A

WDYHV1 ENST00000523984.1 WDYHV motif containing 1 32 1 0 1 0 1 hsa-miR-4498 -0.09 -0.27 N/A

RHCG ENST00000544600.1 Rh family, C glycoprotein 7 3 0 2 1 0 hsa-miR-4498 -0.09 -0.41 N/A Cell growth-inhibiting protein 7; HCG1784586; AL354993.1 ENST00000439873.2 9 1 0 1 0 0 hsa-miR-4498 -0.09 -0.2 N/A Uncharacterized protein MTSS1 ENST00000378017.3 metastasis suppressor 1 10 1 0 1 0 0 hsa-miR-4498 -0.09 -0.17 N/A

TBC1D2 ENST00000375064.1 TBC1 domain family, member 2 873 2 0 2 0 0 hsa-miR-4498 -0.09 -0.14 N/A

BTRC ENST00000370187.3 beta-transducin repeat containing E3 ubiquitin protein ligase 96 2 1 1 0 3 hsa-miR-4498 -0.09 -0.26 N/A low density lipoprotein receptor-related protein 8, LRP8 ENST00000306052.6 16 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.12 N/A apolipoprotein e receptor CDC42BPA ENST00000366767.3 CDC42 binding protein kinase alpha (DMPK-like) 122 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.1 N/A

ENOX2 ENST00000370935.1 ecto-NOX disulfide-thiol exchanger 2 215 2 0 1 1 0 hsa-miR-4498 -0.09 -0.17 N/A

KLRC4 ENST00000309384.1 killer cell lectin-like receptor subfamily C, member 4 9 1 0 1 0 0 hsa-miR-5001-5p -0.09 -0.21 N/A

IDH3G ENST00000370093.1 isocitrate dehydrogenase 3 (NAD+) gamma 391 1 0 1 0 1 hsa-miR-4498 -0.09 -0.09 N/A

SYNRG ENST00000339208.6 synergin, gamma 106 1 0 1 0 1 hsa-miR-4498 -0.09 -0.15 N/A

NFIA ENST00000403491.3 nuclear factor I/A 5 2 0 1 1 2 hsa-miR-4498 -0.09 -0.09 N/A

TTLL7 ENST00000260505.8 tubulin tyrosine ligase-like family, member 7 93 1 0 0 1 0 hsa-miR-5001-5p -0.09 -0.09 N/A

FAM155A ENST00000375915.2 family with sequence similarity 155, member A 118 1 0 1 0 1 hsa-miR-4498 -0.09 -0.09 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PTPRJ ENST00000418331.2 protein tyrosine phosphatase, receptor type, J 145 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.1 N/A

KIAA1671 ENST00000401395.1 KIAA1671 549 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.09 N/A

BTF3L4 ENST00000489308.2 basic transcription factor 3-like 4 1245 2 2 0 0 0 hsa-miR-5001-5p -0.08 -0.89 N/A

RNF24 ENST00000336095.6 ring finger protein 24 448 1 0 0 1 4 hsa-miR-4498 -0.08 -0.29 N/A

ACVR2B ENST00000352511.4 activin A receptor, type IIB 21 1 0 1 0 1 hsa-miR-4498 -0.08 -0.19 N/A

ANGEL1 ENST00000251089.2 angel homolog 1 (Drosophila) 299 2 0 2 0 0 hsa-miR-4498 -0.08 -0.09 N/A

KLK13 ENST00000595793.1 kallikrein-related peptidase 13 9 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.2 N/A

TTC26 ENST00000430935.1 tetratricopeptide repeat domain 26 211 1 0 1 0 0 hsa-miR-5001-5p -0.08 -0.13 N/A

SCYL3 ENST00000367771.6 SCY1-like 3 (S. cerevisiae) 124 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.11 N/A

MSRB3 ENST00000308259.5 methionine sulfoxide reductase B3 83 1 1 0 0 0 hsa-miR-4498 -0.08 -0.27 N/A potassium intermediate/small conductance calcium-activated KCNN3 ENST00000271915.4 5 2 0 1 1 0 hsa-miR-4498 -0.08 -0.08 N/A channel, subfamily N, member 3 AMBRA1 ENST00000314845.3 autophagy/beclin-1 regulator 1 35 1 0 1 0 1 hsa-miR-5001-5p -0.08 -0.08 N/A

PPP2R5D ENST00000485511.1 protein phosphatase 2, regulatory subunit B', delta 1755 1 0 0 1 2 hsa-miR-5001-5p -0.08 -0.08 N/A

COL6A6 ENST00000358511.6 collagen, type VI, alpha 6 5 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

MSANTD3 ENST00000395067.2 Myb/SANT-like DNA-binding domain containing 3 78 2 0 0 2 1 hsa-miR-5001-5p -0.08 -0.17 N/A mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl- MGAT5 ENST00000409645.1 1627 3 0 2 1 1 hsa-miR-4498 -0.08 -0.08 N/A glucosaminyltransferase UCK1 ENST00000372208.3 uridine-cytidine kinase 1 263 1 0 1 0 1 hsa-miR-4498 -0.08 -0.11 N/A

MED22 ENST00000344469.5 mediator complex subunit 22 43 1 0 0 1 3 hsa-miR-5001-5p -0.08 -0.22 N/A

KHNYN ENST00000251343.5 KH and NYN domain containing 421 1 1 0 0 2 hsa-miR-5001-5p -0.08 -0.22 N/A

RNPEPL1 ENST00000270357.4 arginyl aminopeptidase (aminopeptidase B)-like 1 239 2 0 2 0 5 hsa-miR-4498 -0.08 -0.16 N/A

RPL10 ENST00000424325.2 ribosomal protein L10 12 1 0 1 0 2 hsa-miR-4498 -0.08 -0.21 N/A

CDHR1 ENST00000372117.3 cadherin-related family member 1 13 1 0 0 1 3 hsa-miR-5001-5p -0.08 -0.12 N/A

FAM179B ENST00000382233.2 family with sequence similarity 179, member B 12 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

GPR27 ENST00000304411.2 G protein-coupled receptor 27 781 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

SIN3B ENST00000379803.1 SIN3 transcription regulator family member B 1084 1 0 1 0 2 hsa-miR-4498 -0.08 -0.08 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SEZ6L ENST00000360929.3 seizure related 6 homolog (mouse)-like 5 1 0 0 1 2 hsa-miR-5001-5p -0.08 -0.08 N/A Rtf1, Paf1/RNA polymerase II complex component, RTF1 ENST00000389629.4 1869 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.09 N/A homolog (S. cerevisiae) LAMC3 ENST00000361069.4 laminin, gamma 3 17 2 0 2 0 0 hsa-miR-5001-5p -0.08 -0.25 N/A

DPY19L2 ENST00000324472.4 dpy-19-like 2 (C. elegans) 17 1 0 1 0 0 hsa-miR-4498 -0.08 -0.3 N/A

SKIL ENST00000458537.3 SKI-like oncogene 210 1 0 0 1 0 hsa-miR-4498 -0.08 -0.12 N/A

TLR6 ENST00000436693.2 toll-like receptor 6 5 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

HK2 ENST00000290573.2 hexokinase 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.08 N/A

GABRE ENST00000370325.1 gamma-aminobutyric acid (GABA) A receptor, epsilon 6 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.08 N/A

IRAK1BP1 ENST00000369940.2 interleukin-1 receptor-associated kinase 1 binding protein 1 30 2 0 2 0 0 hsa-miR-4498 -0.08 -0.29 N/A regulator of chromosome condensation (RCC1) and BTB RCBTB1 ENST00000258646.3 9 1 0 1 0 0 hsa-miR-4498 -0.08 -0.08 N/A (POZ) domain containing protein 1 STEAP3 ENST00000409811.1 STEAP family member 3, metalloreductase 160 1 0 0 1 2 hsa-miR-5001-5p -0.08 -0.1 N/A

MTMR10 ENST00000435680.1 myotubularin related protein 10 30 1 0 1 0 2 hsa-miR-4498 -0.08 -0.12 N/A

PNMA6B ENST00000370261.1 paraneoplastic Ma antigen family member 6B (pseudogene) 5 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

ATF3 ENST00000366983.1 activating transcription factor 3 2704 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

CTNNA3 ENST00000433211.2 catenin (cadherin-associated protein), alpha 3 5 2 0 0 2 1 hsa-miR-5001-5p -0.08 -0.08 N/A

RGAG4 ENST00000545866.1 retrotransposon gag domain containing 4 34 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.08 N/A CTD (carboxy-terminal domain, RNA polymerase II, CTDSPL ENST00000443503.2 372 1 0 0 1 2 hsa-miR-4498 -0.08 -0.1 N/A polypeptide A) small phosphatase-like PNMA6D ENST00000538162.2 paraneoplastic Ma antigen family member 6D (pseudogene) 5 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

CHMP1A ENST00000397901.3 charged multivesicular body protein 1A 642 1 0 0 1 0 hsa-miR-762 -0.08 -0.08 N/A leucine-rich repeats and calponin homology (CH) domain LRCH4 ENST00000310300.6 248 1 0 1 0 1 hsa-miR-4498 -0.08 -0.18 N/A containing 4 ATG13 ENST00000359513.4 autophagy related 13 834 4 0 3 1 1 hsa-miR-5001-5p -0.08 -0.24 N/A

ADAT1 ENST00000307921.3 adenosine deaminase, tRNA-specific 1 597 2 0 2 0 0 hsa-miR-5001-5p -0.08 -0.09 N/A

ZFAND5 ENST00000237937.3 zinc finger, AN1-type domain 5 2522 2 0 2 0 1 hsa-miR-4498 -0.08 -0.39 N/A

ICK ENST00000350082.5 intestinal cell (MAK-like) kinase 18 1 1 0 0 0 hsa-miR-4498 -0.08 -0.21 N/A

DDA1 ENST00000359866.4 DET1 and DDB1 associated 1 76 1 0 1 0 1 hsa-miR-4498 -0.08 -0.12 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PKIA ENST00000396418.2 protein kinase (cAMP-dependent, catalytic) inhibitor alpha 542 3 1 0 2 2 hsa-miR-5001-5p -0.08 -0.63 N/A

APOOL ENST00000373173.2 apolipoprotein O-like 109 2 0 2 0 0 hsa-miR-5001-5p -0.08 -0.22 N/A

OTUD3 ENST00000375120.3 OTU domain containing 3 438 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.08 N/A potassium voltage-gated channel, KQT-like subfamily, KCNQ5 ENST00000370398.1 50 1 0 1 0 0 hsa-miR-5001-5p -0.08 -0.08 N/A member 5 JAG1 ENST00000254958.5 jagged 1 421 1 0 1 0 0 hsa-miR-4498 -0.08 -0.08 N/A

MAPKAP1 ENST00000373511.2 mitogen-activated protein kinase associated protein 1 1359 1 0 1 0 0 hsa-miR-5001-5p -0.08 -0.08 N/A

RABEP1 ENST00000262477.6 rabaptin, RAB GTPase binding effector protein 1 1163 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

DVL1 ENST00000378891.5 dishevelled segment polarity protein 1 384 1 0 1 0 0 hsa-miR-4498 -0.08 -0.08 N/A

C17orf51 ENST00000391411.5 chromosome 17 open reading frame 51 464 1 0 0 1 0 hsa-miR-4498 -0.08 -0.08 N/A

DAGLA ENST00000257215.5 diacylglycerol lipase, alpha 1262 2 0 0 2 1 hsa-miR-5001-5p -0.08 -0.08 N/A

FBXO32 ENST00000517956.1 F-box protein 32 500 2 0 1 1 1 hsa-miR-4498 -0.08 -0.2 N/A solute carrier family 7 (amino acid transporter light chain, L SLC7A5 ENST00000565644.1 155 1 0 0 1 3 hsa-miR-5001-5p -0.08 -0.08 N/A system), member 5 ZBED3 ENST00000255198.2 zinc finger, BED-type containing 3 399 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.1 N/A

FAF2 ENST00000261942.6 Fas associated factor family member 2 1700 1 0 1 0 0 hsa-miR-4498 -0.08 -0.1 N/A

UBE2N ENST00000550657.1 ubiquitin-conjugating enzyme E2N 321 1 0 1 0 2 hsa-miR-4498 -0.08 -0.21 N/A

FOPNL ENST00000573396.1 FGFR1OP N-terminal like 29 1 0 1 0 0 hsa-miR-5001-5p -0.08 -0.12 N/A transcription elongation factor A (SII) N-terminal and TCEANC2 ENST00000234827.1 78 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.18 N/A central domain containing 2 IVD ENST00000249760.2 isovaleryl-CoA dehydrogenase 484 2 0 1 1 2 hsa-miR-5001-5p -0.08 -0.56 N/A

RYBP ENST00000477973.2 RING1 and YY1 binding protein 342 1 0 1 0 1 hsa-miR-4498 -0.08 -0.1 N/A

RAPGEF5 ENST00000401957.2 Rap guanine nucleotide exchange factor (GEF) 5 32 1 0 1 0 0 hsa-miR-4498 -0.08 -0.08 N/A

ZNF512B ENST00000369888.1 zinc finger protein 512B 8 1 0 1 0 1 hsa-miR-5001-5p -0.08 -0.08 N/A

DIAPH1 ENST00000389054.3 diaphanous-related formin 1 399 1 0 1 0 1 hsa-miR-5001-5p -0.08 -0.08 N/A

KCTD9 ENST00000221200.4 potassium channel tetramerization domain containing 9 575 1 0 1 0 0 hsa-miR-4498 -0.08 -0.25 N/A

GATA6 ENST00000269216.3 GATA binding protein 6 691 1 0 1 0 1 hsa-miR-4498 -0.08 -0.12 N/A

NFX1 ENST00000379540.3 nuclear transcription factor, X-box binding 1 215 1 0 0 1 0 hsa-miR-4498 -0.08 -0.12 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CBR4 ENST00000306193.3 carbonyl reductase 4 90 1 0 0 1 0 hsa-miR-762 -0.08 -0.12 N/A

CARD8 ENST00000520753.1 caspase recruitment domain family, member 8 159 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.1 N/A

INPP4B ENST00000513000.1 inositol polyphosphate-4-phosphatase, type II, 105kDa 43 1 0 1 0 0 hsa-miR-4498 -0.08 -0.15 N/A

KLHL6 ENST00000341319.3 kelch-like family member 6 5 1 0 1 0 1 hsa-miR-5001-5p -0.08 -0.08 N/A

KDM4A ENST00000372396.3 lysine (K)-specific demethylase 4A 257 1 0 1 0 0 hsa-miR-5001-5p -0.08 -0.08 N/A

TACR3 ENST00000304883.2 tachykinin receptor 3 5 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

OTUD7A ENST00000307050.4 OTU domain containing 7A 35 1 0 1 0 2 hsa-miR-4498 -0.08 -0.12 N/A fission 1 (mitochondrial outer membrane) homolog (S. FIS1 ENST00000474120.1 11997 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.28 N/A cerevisiae) TRIM71 ENST00000383763.5 tripartite motif containing 71, E3 ubiquitin protein ligase 67 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

PEAK1 ENST00000312493.4 pseudopodium-enriched atypical kinase 1 209 1 0 0 1 1 hsa-miR-5001-5p -0.08 -0.08 N/A

ZMAT3 ENST00000311417.2 zinc finger, matrin-type 3 459 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.14 N/A

PTPRU ENST00000428026.2 protein tyrosine phosphatase, receptor type, U 261 2 0 2 0 3 hsa-miR-4498 -0.08 -0.12 N/A

EVX1 ENST00000222761.3 even-skipped homeobox 1 7 1 0 1 0 1 hsa-miR-5001-5p -0.08 -0.21 N/A

ZNF45 ENST00000269973.5 zinc finger protein 45 359 1 0 1 0 0 hsa-miR-4498 -0.08 -0.23 N/A

EAF1 ENST00000396842.2 ELL associated factor 1 63 1 0 0 1 0 hsa-miR-5001-5p -0.08 -0.08 N/A

CGNL1 ENST00000281282.5 cingulin-like 1 25 2 0 0 2 1 hsa-miR-5001-5p -0.08 -0.08 N/A

C19orf26 ENST00000590083.1 chromosome 19 open reading frame 26 24 1 0 0 1 4 hsa-miR-5001-5p -0.08 -0.08 N/A

RAB11FIP5 ENST00000258098.6 RAB11 family interacting protein 5 (class I) 81 2 0 2 0 0 hsa-miR-4498 -0.08 -0.28 N/A XXcos- ENST00000606589.1 7 2* 0 1 0 0 hsa-miR-4498 -0.08 -0.25 N/A LUCA11.5 HDAC5 ENST00000225983.6 histone deacetylase 5 266 3 1 2 0 0 hsa-miR-4498 -0.08 -0.48 N/A

FZD2 ENST00000315323.3 frizzled family receptor 2 807 1 0 1 0 1 hsa-miR-4498 -0.08 -0.27 N/A

KLHL11 ENST00000319121.3 kelch-like family member 11 16 1 0 1 0 0 hsa-miR-4498 -0.08 -0.11 N/A

LINC00346 ENST00000538077.1 long intergenic non-protein coding RNA 346 26 2 1 0 1 1 hsa-miR-5001-5p -0.08 -0.38 N/A

IFFO2 ENST00000455833.2 intermediate filament family orphan 2 139 2 1 1 0 0 hsa-miR-5001-5p -0.08 -0.09 N/A

BBS4 ENST00000268057.4 Bardet-Biedl syndrome 4 121 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZC3H12D ENST00000416573.2 zinc finger CCCH-type containing 12D 13 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.12 N/A

MXD4 ENST00000337190.2 MAX dimerization protein 4 1173 3 2 0 1 4 hsa-miR-5001-5p -0.07 -0.55 N/A

SLU7 ENST00000297151.4 SLU7 splicing factor homolog (S. cerevisiae) 320 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.15 N/A

AFF4 ENST00000265343.5 AF4/FMR2 family, member 4 2755 2 1 0 1 0 hsa-miR-5001-5p -0.07 -0.08 N/A

CERK ENST00000216264.8 ceramide kinase 123 1 0 0 1 1 hsa-miR-4498 -0.07 -0.08 N/A

MRRF ENST00000344641.3 mitochondrial ribosome recycling factor 85 2 0 1 1 1 hsa-miR-5001-5p -0.07 -0.34 N/A

CLPB ENST00000294053.3 ClpB caseinolytic peptidase B homolog (E. coli) 476 1 0 0 1 3 hsa-miR-5001-5p -0.07 -0.27 N/A

BARHL2 ENST00000370445.4 BarH-like homeobox 2 13 1 0 1 0 0 hsa-miR-5001-5p -0.07 -0.07 N/A

CDH4 ENST00000360469.5 cadherin 4, type 1, R-cadherin (retinal) 33 1 0 1 0 3 hsa-miR-4498 -0.07 -0.07 N/A

CA12 ENST00000178638.3 carbonic anhydrase XII 42 2 0 1 1 6 hsa-miR-5001-5p -0.07 -0.2 N/A

ALDH7A1 ENST00000409134.3 aldehyde dehydrogenase 7 family, member A1 2007 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.08 N/A

DHDDS ENST00000360009.2 dehydrodolichyl diphosphate synthase 325 1 0 0 1 0 hsa-miR-4498 -0.07 -0.15 N/A

LDLR ENST00000558518.1 low density lipoprotein receptor 1462 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.09 N/A

SNX27 ENST00000368843.3 sorting nexin family member 27 46 1 0 1 0 1 hsa-miR-4498 -0.07 -0.07 N/A

ANKRD13B ENST00000394859.3 ankyrin repeat domain 13B 72 2 0 2 0 0 hsa-miR-4498 -0.07 -0.07 N/A

DTX4 ENST00000227451.3 deltex homolog 4 (Drosophila) 5 1 0 1 0 0 hsa-miR-4498 -0.07 -0.07 N/A

FRMD4B ENST00000398540.3 FERM domain containing 4B 12 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

FAM124B ENST00000389874.3 family with sequence similarity 124B 5 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

RAB22A ENST00000244040.3 RAB22A, member RAS oncogene family 484 1 0 0 1 1 hsa-miR-4498 -0.07 -0.13 N/A

PDLIM5 ENST00000437932.1 PDZ and LIM domain 5 1002 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.1 N/A

FAM110B ENST00000361488.3 family with sequence similarity 110, member B 60 1 1 0 0 0 hsa-miR-5001-5p -0.07 -0.38 N/A

PNP ENST00000361505.5 purine nucleoside phosphorylase 50 1 0 1 0 0 hsa-miR-4498 -0.07 -0.17 N/A

SP1 ENST00000426431.2 Sp1 transcription factor 402 1 0 1 0 1 hsa-miR-4498 -0.07 -0.17 N/A

LONRF3 ENST00000304778.7 LON peptidase N-terminal domain and ring finger 3 36 3 0 0 3 1 hsa-miR-5001-5p -0.07 -0.17 N/A

LRRTM2 ENST00000274711.6 leucine rich repeat transmembrane neuronal 2 5 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ZNF445 ENST00000425708.2 zinc finger protein 445 370 2 0 2 0 1 hsa-miR-4498 -0.07 -0.07 N/A

WLS ENST00000262348.4 wntless Wnt ligand secretion mediator 2540 1 0 1 0 0 hsa-miR-4498 -0.07 -0.07 N/A

NBPF12 ENST00000446760.2 neuroblastoma breakpoint family, member 12 5 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A

EHD1 ENST00000320631.3 EH-domain containing 1 335 5 0 4 1 1 hsa-miR-5001-5p -0.07 -0.68 N/A

CAPN12 ENST00000601953.1 calpain 12 14 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.14 N/A sperm antigen with calponin homology and coiled-coil SPECC1L ENST00000314328.9 3720 3 0 2 1 1 hsa-miR-4498 -0.07 -0.22 N/A domains 1-like MECP2 ENST00000303391.6 methyl CpG binding protein 2 (Rett syndrome) 1474 5 1 3 1 2 hsa-miR-4498 -0.07 -0.43 N/A

RPRD2 ENST00000539519.1 regulation of nuclear pre-mRNA domain containing 2 280 1 0 1 0 1 hsa-miR-4498 -0.07 -0.07 N/A

WDR82 ENST00000296490.3 WD repeat domain 82 319 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

NSD1 ENST00000439151.2 nuclear receptor binding SET domain protein 1 685 2 0 2 0 0 hsa-miR-4498 -0.07 -0.26 N/A

RAI1 ENST00000353383.1 retinoic acid induced 1 277 1 1 0 0 2 hsa-miR-5001-5p -0.07 -0.08 N/A

NRP1 ENST00000374875.1 neuropilin 1 586 1 0 1 0 0 hsa-miR-5001-5p -0.07 -0.07 N/A

CCDC88B ENST00000356786.5 coiled-coil domain containing 88B 155 1 0 0 1 0 hsa-miR-762 -0.07 -0.07 N/A

RAB1B ENST00000311481.6 RAB1B, member RAS oncogene family 5 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

HNF4G ENST00000396423.2 hepatocyte nuclear factor 4, gamma 5 1 0 0 1 0 hsa-miR-4498 -0.07 -0.07 N/A

NBEAL2 ENST00000450053.3 neurobeachin-like 2 70 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

NUP205 ENST00000285968.6 nucleoporin 205kDa 11 2 0 2 0 1 hsa-miR-4498 -0.07 -0.25 N/A

RNF216 ENST00000425013.2 ring finger protein 216 649 1 0 0 1 3 hsa-miR-5001-5p -0.07 -0.1 N/A

SAMD8 ENST00000372687.4 sterile alpha motif domain containing 8 100 1 0 1 0 0 hsa-miR-4498 -0.07 -0.15 N/A

SNX33 ENST00000308527.5 sorting nexin 33 148 3 0 3 0 1 hsa-miR-5001-5p -0.07 -0.09 N/A

GSTK1 ENST00000358406.5 glutathione S-transferase kappa 1 299 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.17 N/A

NSMCE1 ENST00000361439.4 non-SMC element 1 homolog (S. cerevisiae) 1418 6 1 4 1 5 hsa-miR-5001-5p -0.07 -0.9 N/A

CREB3L2 ENST00000330387.6 cAMP responsive element binding protein 3-like 2 2872 1 0 0 1 3 hsa-miR-5001-5p -0.07 -0.08 N/A

HOXB6 ENST00000484302.2 homeobox B6 12 1 0 1 0 0 hsa-miR-4498 -0.07 -0.17 N/A

EPAS1 ENST00000263734.3 endothelial PAS domain protein 1 3689 1 0 1 0 1 hsa-miR-5001-5p -0.07 -0.07 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score BACE1 ENST00000313005.6 beta-site APP-cleaving enzyme 1 486 1 0 1 0 2 hsa-miR-4498 -0.07 -0.14 N/A

BRD3 ENST00000303407.7 bromodomain containing 3 77 3 0 2 1 1 hsa-miR-5001-5p -0.07 -0.16 N/A

ZNF827 ENST00000379448.4 zinc finger protein 827 17 3 0 2 1 1 hsa-miR-4498 -0.07 -0.14 N/A

CELSR2 ENST00000271332.3 cadherin, EGF LAG seven-pass G-type receptor 2 2475 2 0 1 1 2 hsa-miR-5001-5p -0.07 -0.07 N/A

NUP188 ENST00000372577.2 nucleoporin 188kDa 3481 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

DSCAM ENST00000400454.1 Down syndrome cell adhesion molecule 5 1 1 0 0 0 hsa-miR-5001-5p -0.07 -0.07 N/A

SCMH1 ENST00000361705.3 sex comb on midleg homolog 1 (Drosophila) 234 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A

JMJD1C ENST00000399251.1 jumonji domain containing 1C 60 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A immunoglobulin superfamily containing leucine-rich repeat ISLR2 ENST00000361742.3 5 1 0 1 0 2 hsa-miR-4498 -0.07 -0.07 N/A 2 CLEC2D ENST00000261340.7 C-type lectin domain family 2, member D 11 1 0 1 0 0 hsa-miR-5001-5p -0.07 -0.13 N/A

RAPGEF3 ENST00000405493.2 Rap guanine nucleotide exchange factor (GEF) 3 19 3 2 0 1 3 hsa-miR-5001-5p -0.07 -0.29 N/A

EDC3 ENST00000315127.4 enhancer of mRNA decapping 3 328 1 0 1 0 2 hsa-miR-5001-5p -0.07 -0.22 N/A

EFR3B ENST00000403714.3 EFR3 homolog B (S. cerevisiae) 14 1 0 1 0 0 hsa-miR-5001-5p -0.07 -0.11 N/A

ENTPD1 ENST00000371207.3 ectonucleoside triphosphate diphosphohydrolase 1 15 4 2 1 1 0 hsa-miR-5001-5p -0.07 -0.21 N/A

C20orf112 ENST00000359676.5 chromosome 20 open reading frame 112 148 1 0 1 0 1 hsa-miR-4498 -0.07 -0.11 N/A

BACE2 ENST00000328735.6 beta-site APP-cleaving enzyme 2 79 2 1 1 0 1 hsa-miR-5001-5p -0.07 -0.23 N/A

PPP6C ENST00000373547.4 protein phosphatase 6, catalytic subunit 346 2 1 1 0 0 hsa-miR-5001-5p -0.07 -0.45 N/A

DNAJA4 ENST00000394855.3 DnaJ (Hsp40) homolog, subfamily A, member 4 24 2 0 0 2 0 hsa-miR-5001-5p -0.07 -0.21 N/A

NBPF9 ENST00000440491.2 neuroblastoma breakpoint family, member 9 5 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A

DCX ENST00000356915.2 doublecortin 5 1 0 0 1 2 hsa-miR-5001-5p -0.07 -0.07 N/A

PHB2 ENST00000546111.1 prohibitin 2 120 2 0 1 1 4 hsa-miR-4498 -0.07 -0.56 N/A

KLHL38 ENST00000325995.7 kelch-like family member 38 13 2 0 1 1 1 hsa-miR-5001-5p -0.07 -0.2 N/A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- MGAT4A ENST00000264968.3 223 2 0 1 1 0 hsa-miR-5001-5p -0.07 -0.31 N/A acetylglucosaminyltransferase, isozyme A RAB6B ENST00000285208.4 RAB6B, member RAS oncogene family 669 3 2 1 0 2 hsa-miR-5001-5p -0.07 -0.86 N/A

BCAR1 ENST00000162330.5 breast cancer anti-estrogen resistance 1 432 3 0 1 2 2 hsa-miR-5001-5p -0.07 -0.61 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score solute carrier family 16 (monocarboxylate transporter), SLC16A7 ENST00000261187.4 73 1 0 0 1 0 hsa-miR-4498 -0.07 -0.12 N/A member 7 MBP ENST00000397863.1 myelin basic protein 96 1 0 0 1 0 hsa-miR-4498 -0.07 -0.07 N/A

C9orf139 ENST00000314330.2 chromosome 9 open reading frame 139 5 2 0 2 0 1 hsa-miR-5001-5p -0.07 -0.07 N/A solute carrier family 43 (amino acid system L transporter), SLC43A1 ENST00000278426.3 483 1 0 1 0 1 hsa-miR-4498 -0.07 -0.13 N/A member 1 CTD (carboxy-terminal domain, RNA polymerase II, CTDSPL2 ENST00000260327.4 457 1 0 1 0 0 hsa-miR-4498 -0.07 -0.1 N/A polypeptide A) small phosphatase like 2 TRAPPC2L ENST00000565504.1 trafficking protein particle complex 2-like 1619 2 1 1 0 3 hsa-miR-5001-5p -0.07 -0.47 N/A

CAMK1D ENST00000378847.3 calcium/calmodulin-dependent protein kinase ID 258 2 0 1 1 3 hsa-miR-5001-5p -0.07 -0.15 N/A

DNAJA2 ENST00000317089.5 DnaJ (Hsp40) homolog, subfamily A, member 2 1487 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.19 N/A

BMF ENST00000220446.4 Bcl2 modifying factor 179 1 0 0 1 2 hsa-miR-5001-5p -0.07 -0.09 N/A

ZNF548 ENST00000366197.5 zinc finger protein 548 98 1 1 0 0 0 hsa-miR-5001-5p -0.07 -0.39 N/A

WDR91 ENST00000344400.5 WD repeat domain 91 46 3 3 0 0 1 hsa-miR-5001-5p -0.07 -0.47 N/A

PDE4A ENST00000380702.2 phosphodiesterase 4A, cAMP-specific 48 1 0 1 0 2 hsa-miR-5001-5p -0.07 -0.07 N/A

PTPRH ENST00000376350.3 protein tyrosine phosphatase, receptor type, H 21 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

FAM101A ENST00000546355.1 family with sequence similarity 101, member A 34 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A

IL6R ENST00000344086.4 interleukin 6 receptor 13 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

LMNB2 ENST00000325327.3 lamin B2 89 3 0 3 0 0 hsa-miR-4498 -0.07 -0.29 N/A

FAM192A ENST00000309137.8 family with sequence similarity 192, member A 502 1 1 0 0 0 hsa-miR-5001-5p -0.07 -0.39 N/A

ARPC2 ENST00000295685.10 actin related protein 2/3 complex, subunit 2, 34kDa 153 2 0 0 2 0 hsa-miR-5001-5p -0.07 -0.31 N/A

DERL3 ENST00000404056.1 derlin 3 129 2 0 0 2 1 hsa-miR-5001-5p -0.07 -0.26 N/A

SERINC5 ENST00000512721.1 serine incorporator 5 175 1 1 0 0 1 hsa-miR-5001-5p -0.07 -0.07 N/A inhibitor of kappa light polypeptide gene enhancer in B- IKBKB ENST00000379708.3 806 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.07 N/A cells, kinase beta LRIG2 ENST00000361127.5 leucine-rich repeats and immunoglobulin-like domains 2 348 1 0 1 0 1 hsa-miR-5001-5p -0.07 -0.07 N/A

MYLK ENST00000360772.3 myosin light chain kinase 2964 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

B4GALNT4 ENST00000329962.6 beta-1,4-N-acetyl-galactosaminyl transferase 4 3266 1 0 1 0 0 hsa-miR-4498 -0.07 -0.07 N/A

IP6K3 ENST00000451316.1 inositol hexakisphosphate kinase 3 8 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score DST ENST00000312431.6 dystonin 439 3 0 1 2 3 hsa-miR-4498 -0.07 -0.07 N/A membrane associated guanylate kinase, WW and PDZ MAGI1 ENST00000330909.8 258 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.15 N/A domain containing 1 IRF2BP2 ENST00000366610.3 interferon regulatory factor 2 binding protein 2 8690 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.09 N/A

RALGAPB ENST00000397038.1 Ral GTPase activating protein, beta subunit (non-catalytic) 1120 1 0 0 1 1 hsa-miR-5001-5p -0.07 -0.08 N/A

NEK3 ENST00000339406.3 NIMA-related kinase 3 66 1 0 1 0 2 hsa-miR-4498 -0.07 -0.26 N/A

FSD2 ENST00000334574.8 fibronectin type III and SPRY domain containing 2 5 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

FGFR3 ENST00000340107.4 fibroblast growth factor receptor 3 1085 1 0 0 1 0 hsa-miR-5001-5p -0.07 -0.07 N/A

PADI4 ENST00000375448.4 peptidyl arginine deiminase, type IV 5 1 0 1 0 0 hsa-miR-5001-5p -0.07 -0.07 N/A

NME6 ENST00000450160.1 NME/NM23 nucleoside diphosphate kinase 6 511 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.26 N/A

HOGA1 ENST00000370647.4 4-hydroxy-2-oxoglutarate aldolase 1 10 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.14 N/A

UBIAD1 ENST00000376810.5 UbiA prenyltransferase domain containing 1 303 1 0 1 0 0 hsa-miR-4498 -0.06 -0.14 N/A

C2orf82 ENST00000409533.1 chromosome 2 open reading frame 82 72 1 0 1 0 4 hsa-miR-4498 -0.06 -0.26 N/A

CXXC4 ENST00000394767.2 CXXC finger protein 4 121 1 1 0 0 0 hsa-miR-5001-5p -0.06 -0.07 N/A

PRDM2 ENST00000235372.7 PR domain containing 2, with ZNF domain 29 2 0 0 2 0 hsa-miR-5001-5p -0.06 -0.06 N/A

PEG10 ENST00000482108.1 paternally expressed 10 8778 1 0 0 1 0 hsa-miR-4498 -0.06 -0.06 N/A

GRIN1 ENST00000371561.3 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9 1 0 0 1 2 hsa-miR-5001-5p -0.06 -0.06 N/A solute carrier family 22 (organic anion/urate transporter), SLC22A11 ENST00000301891.4 7 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.09 N/A member 11 RAPGEF1 ENST00000372189.3 Rap guanine nucleotide exchange factor (GEF) 1 335 2 1 1 0 2 hsa-miR-5001-5p -0.06 -0.06 N/A

RANBP3 ENST00000439268.2 RAN binding protein 3 908 2 0 2 0 0 hsa-miR-4498 -0.06 -0.22 N/A

MED16 ENST00000269814.4 mediator complex subunit 16 3677 2 0 1 1 2 hsa-miR-5001-5p -0.06 -0.33 N/A

SHH ENST00000297261.2 sonic hedgehog 32 3 0 1 2 2 hsa-miR-5001-5p -0.06 -0.23 N/A

CD47 ENST00000361309.5 CD47 molecule 520 1 0 1 0 0 hsa-miR-4498 -0.06 -0.14 N/A

PPP1R13B ENST00000423488.2 protein phosphatase 1, regulatory subunit 13B 105 1 1 0 0 1 hsa-miR-5001-5p -0.06 -0.64 N/A

BAG5 ENST00000299204.4 BCL2-associated athanogene 5 267 1 1 0 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A

CALCOCO1 ENST00000548263.1 calcium binding and coiled-coil domain 1 68 1 0 1 0 0 hsa-miR-4498 -0.06 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ANKRD9 ENST00000559651.1 ankyrin repeat domain 9 766 3 0 2 1 1 hsa-miR-5001-5p -0.06 -0.43 N/A

PRSS21 ENST00000455114.1 protease, serine, 21 (testisin) 578 1 1 0 0 1 hsa-miR-5001-5p -0.06 -0.32 N/A

WBSCR27 ENST00000297873.4 Williams Beuren syndrome chromosome region 27 17 1 0 1 0 0 hsa-miR-4498 -0.06 -0.25 N/A

UMPS ENST00000232607.2 uridine monophosphate synthetase 374 3 0 2 1 1 hsa-miR-5001-5p -0.06 -0.43 N/A

CYP1A2 ENST00000343932.4 cytochrome P450, family 1, subfamily A, polypeptide 2 5 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.32 N/A

SERPINB8 ENST00000397985.2 serpin peptidase inhibitor, clade B (ovalbumin), member 8 285 1 0 1 0 1 hsa-miR-4498 -0.06 -0.15 N/A

RALGAPA1 ENST00000389698.3 Ral GTPase activating protein, alpha subunit 1 (catalytic) 82 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ST8SIA4 ENST00000231461.5 5 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A 4 LOXL1 ENST00000261921.7 lysyl oxidase-like 1 1361 1 0 1 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A

PARP6 ENST00000260376.7 poly (ADP-ribose) polymerase family, member 6 867 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A

HIST2H2AA3 ENST00000369161.3 histone cluster 2, H2aa3 5 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A

BCL2 ENST00000398117.1 B-cell CLL/lymphoma 2 55 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.07 N/A

GFRA3 ENST00000274721.3 GDNF family receptor alpha 3 7 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A

SART3 ENST00000228284.3 squamous cell carcinoma antigen recognized by T cells 3 469 2 0 1 1 1 hsa-miR-5001-5p -0.06 -0.24 N/A

TIGD6 ENST00000296736.3 tigger transposable element derived 6 155 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.27 N/A

PLXNB1 ENST00000296440.6 plexin B1 47 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.08 N/A

SRSF1 ENST00000258962.4 serine/arginine-rich splicing factor 1 1430 1 0 0 1 2 hsa-miR-5001-5p -0.06 -0.15 N/A translocase of inner mitochondrial membrane 8 homolog B TIMM8B ENST00000504148.2 12 2 0 1 1 0 hsa-miR-4498 -0.06 -0.58 N/A (yeast) LRP3 ENST00000253193.7 low density lipoprotein receptor-related protein 3 135 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.22 N/A

SMURF1 ENST00000361368.2 SMAD specific E3 ubiquitin protein ligase 1 58 2 0 0 2 2 hsa-miR-5001-5p -0.06 -0.22 N/A phosphoribosyl pyrophosphate synthetase-associated protein PRPSAP1 ENST00000446526.3 2649 1 1 0 0 1 hsa-miR-5001-5p -0.06 -0.42 N/A 1 VIPR1 ENST00000433647.1 vasoactive intestinal peptide receptor 1 37 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.06 N/A polymerase (RNA) III (DNA directed) polypeptide D, POLR3D ENST00000397802.4 678 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.12 N/A 44kDa CDP-diacylglycerol synthase (phosphatidate CDS2 ENST00000460006.1 782 4 0 3 1 3 hsa-miR-4498 -0.06 -0.3 N/A cytidylyltransferase) 2 RAB3A ENST00000222256.4 RAB3A, member RAS oncogene family 10 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CLU ENST00000316403.10 clusterin 219339 1* 0 0 0 1 hsa-miR-5001-5p -0.06 -0.06 N/A

EEF1A1 ENST00000316292.9 eukaryotic translation elongation factor 1 alpha 1 129 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.08 N/A

ZDHHC14 ENST00000359775.5 zinc finger, DHHC-type containing 14 253 1 0 1 0 3 hsa-miR-4498 -0.06 -0.21 N/A

MTMR12 ENST00000280285.5 myotubularin related protein 12 156 1 0 1 0 0 hsa-miR-4498 -0.06 -0.1 N/A

FAM118A ENST00000216214.3 family with sequence similarity 118, member A 202 1 0 0 1 1 hsa-miR-4498 -0.06 -0.22 N/A

PPP4R1L ENST00000334187.8 protein phosphatase 4, regulatory subunit 1-like 27 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.1 N/A

AC005606.1 ENST00000598236.1 LOC283868 protein; Uncharacterized protein 26 1 0 1 0 1 hsa-miR-4498 -0.06 -0.34 N/A

PDP2 ENST00000311765.2 pyruvate dehyrogenase phosphatase catalytic subunit 2 102 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.14 N/A endonuclease/exonuclease/phosphatase family domain EEPD1 ENST00000242108.4 39 1 0 1 0 1 hsa-miR-4498 -0.06 -0.29 N/A containing 1 ZNF704 ENST00000327835.3 zinc finger protein 704 124 1 0 0 1 5 hsa-miR-5001-5p -0.06 -0.08 N/A

DPCR1 ENST00000462446.1 diffuse panbronchiolitis critical region 1 5 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A amyloid beta (A4) precursor protein-binding, family A, APBA1 ENST00000265381.4 12 2 1 1 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A member 1 GPR111 ENST00000398742.2 G protein-coupled receptor 111 5 1 0 1 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A

RAB5B ENST00000553116.1 RAB5B, member RAS oncogene family 14 1 0 1 0 1 hsa-miR-4498 -0.06 -0.18 N/A

LAYN ENST00000525126.1 layilin 175 1 0 0 1 3 hsa-miR-5001-5p -0.06 -0.21 N/A

POGK ENST00000367875.1 pogo transposable element with KRAB domain 377 1 0 1 0 1 hsa-miR-5001-5p -0.06 -0.06 N/A

MCF2L2 ENST00000328913.3 MCF.2 cell line derived transforming sequence-like 2 5 3 1 1 1 0 hsa-miR-5001-5p -0.06 -0.23 N/A

WTIP ENST00000590071.2 Wilms tumor 1 interacting protein 1303 7 1 6 0 3 hsa-miR-4498 -0.06 -0.42 N/A

PCYT2 ENST00000538936.2 phosphate cytidylyltransferase 2, ethanolamine 2340 6 1 3 2 2 hsa-miR-5001-5p -0.06 -0.47 N/A

GBP4 ENST00000355754.6 guanylate binding protein 4 5 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.06 N/A

DOT1L ENST00000398665.3 DOT1-like histone H3K79 methyltransferase 439 3 0 2 1 1 hsa-miR-4498 -0.06 -0.07 N/A

NBPF24 ENST00000369226.3 neuroblastoma breakpoint family, member 24 5 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.08 N/A

ISG20 ENST00000306072.5 interferon stimulated exonuclease gene 20kDa 116 1 0 1 0 0 hsa-miR-4498 -0.06 -0.32 N/A

DNAJB13 ENST00000339764.1 DnaJ (Hsp40) homolog, subfamily B, member 13 7 2 0 2 0 1 hsa-miR-5001-5p -0.06 -0.27 N/A glucosamine (UDP-N-acetyl)-2-epimerase/N- GNE ENST00000396594.3 22 1 0 1 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A acetylmannosamine kinase Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MRPS5 ENST00000272418.2 mitochondrial ribosomal protein S5 71 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.12 N/A

PTBP3 ENST00000374257.1 polypyrimidine tract binding protein 3 214 1 0 1 0 0 hsa-miR-4498 -0.06 -0.14 N/A

RSPH9 ENST00000372163.4 radial spoke head 9 homolog (Chlamydomonas) 13 2 0 0 2 1 hsa-miR-5001-5p -0.06 -0.16 N/A

METTL2B ENST00000480046.1 methyltransferase like 2B 22 1 0 1 0 1 hsa-miR-4498 -0.06 -0.27 N/A

CHMP3 ENST00000263856.4 charged multivesicular body protein 3 2466 3 1 1 1 0 hsa-miR-4498 -0.06 -0.5 N/A

PRKCQ ENST00000263125.5 protein kinase C, theta 7 1 0 1 0 0 hsa-miR-5001-5p -0.06 -0.06 N/A

RALGPS2 ENST00000367635.3 Ral GEF with PH domain and SH3 binding motif 2 201 1 0 0 1 0 hsa-miR-4498 -0.06 -0.06 N/A

SLCO4C1 ENST00000310954.6 solute carrier organic anion transporter family, member 4C1 13 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A

MYNN ENST00000544106.1 myoneurin 289 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.17 N/A

POLR3C ENST00000369294.1 polymerase (RNA) III (DNA directed) polypeptide C (62kD) 582 1 0 0 1 0 hsa-miR-4498 -0.06 -0.16 N/A

SULT1C2 ENST00000251481.6 sulfotransferase family, cytosolic, 1C, member 2 16 1 0 1 0 1 hsa-miR-4498 -0.06 -0.19 N/A

METRN ENST00000568223.2 meteorin, glial cell differentiation regulator 57 4 2 1 1 1 hsa-miR-4498 -0.06 -0.84 N/A

PLXNA1 ENST00000393409.2 plexin A1 189 4 1 3 0 4 hsa-miR-4492 -0.06 -0.09 N/A

TRAF3IP2 ENST00000368761.5 TRAF3 interacting protein 2 44 1 1 0 0 0 hsa-miR-5001-5p -0.06 -0.19 N/A

NEMF ENST00000298310.5 nuclear export mediator factor 18 1 0 1 0 0 hsa-miR-4498 -0.06 -0.21 N/A

SSH1 ENST00000360239.3 slingshot protein phosphatase 1 115 1 0 1 0 1 hsa-miR-4498 -0.06 -0.09 N/A

HPGDS ENST00000295256.5 hematopoietic prostaglandin D synthase 5 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A

DLG5 ENST00000372391.2 discs, large homolog 5 (Drosophila) 10 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A

AVL9 ENST00000318709.4 AVL9 homolog (S. cerevisiase) 246 1 0 0 1 1 hsa-miR-4498 -0.06 -0.08 N/A

ELOVL6 ENST00000394607.3 ELOVL fatty acid elongase 6 901 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.06 N/A

STX7 ENST00000367941.2 syntaxin 7 1395 1 1 0 0 0 hsa-miR-5001-5p -0.06 -0.17 N/A

GTF3C3 ENST00000263956.3 general transcription factor IIIC, polypeptide 3, 102kDa 248 1 1 0 0 0 hsa-miR-4498 -0.06 -0.18 N/A

IGF1 ENST00000337514.6 insulin-like growth factor 1 (somatomedin C) 19 1 0 1 0 0 hsa-miR-4498 -0.06 -0.23 N/A

MYO5A ENST00000399231.3 myosin VA (heavy chain 12, myoxin) 573 1 0 0 1 4 hsa-miR-5001-5p -0.06 -0.13 N/A

HOXC11 ENST00000546378.1 homeobox C11 80 2 0 1 1 0 hsa-miR-4498 -0.06 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score HEYL ENST00000372852.3 hairy/enhancer-of-split related with YRPW motif-like 37 2 0 1 1 2 hsa-miR-4498 -0.06 -0.6 N/A

RNF103-CHMP3 ENST00000604011.1 RNF103-CHMP3 readthrough 2466 3 1 1 1 0 hsa-miR-4498 -0.06 -0.48 N/A

NBPF11 ENST00000604938.1 neuroblastoma breakpoint family, member 11 5 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.06 N/A

INTS3 ENST00000318967.2 integrator complex subunit 3 88 1 0 1 0 3 hsa-miR-4498 -0.06 -0.06 N/A

GLG1 ENST00000422840.2 golgi glycoprotein 1 2175 1 0 1 0 3 hsa-miR-4498 -0.06 -0.17 N/A

ATP2B4 ENST00000367218.3 ATPase, Ca++ transporting, plasma membrane 4 7311 1 0 1 0 1 hsa-miR-4498 -0.06 -0.06 N/A

FAM47E-STBD1 ENST00000237642.6 FAM47E-STBD1 readthrough 503 1 0 0 1 1 hsa-miR-4498 -0.06 -0.07 N/A

INTU ENST00000335251.6 inturned planar cell polarity protein 105 1 0 0 1 2 hsa-miR-5001-5p -0.06 -0.09 N/A

MFF ENST00000304593.9 mitochondrial fission factor 129 1 0 1 0 0 hsa-miR-4498 -0.06 -0.26 N/A

ZNF285 ENST00000330997.4 zinc finger protein 285 31 1 1 0 0 1 hsa-miR-5001-5p -0.06 -0.16 N/A

CTNNBIP1 ENST00000377263.1 catenin, beta interacting protein 1 493 1 0 0 1 1 hsa-miR-5001-5p -0.06 -0.17 N/A

DCP1A ENST00000607628.1 decapping mRNA 1A 87 1 0 0 1 2 hsa-miR-5001-5p -0.06 -0.06 N/A

ATXN2L ENST00000336783.4 ataxin 2-like 5 1 0 1 0 2 hsa-miR-5001-5p -0.06 -0.06 N/A

EFCAB6 ENST00000356087.4 EF-hand calcium binding domain 6 23 1 0 0 1 0 hsa-miR-5001-5p -0.06 -0.07 N/A

TSPAN17 ENST00000298564.10 tetraspanin 17 849 1 0 1 0 0 hsa-miR-4498 -0.06 -0.06 N/A

SUV420H1 ENST00000304363.4 suppressor of variegation 4-20 homolog 1 (Drosophila) 62 2 0 1 1 0 hsa-miR-4498 -0.06 -0.21 N/A

ANAPC1 ENST00000341068.3 anaphase promoting complex subunit 1 47 1 0 0 1 0 hsa-miR-4498 -0.06 -0.06 N/A

ZNF200 ENST00000396868.3 zinc finger protein 200 269 1 0 1 0 0 hsa-miR-4498 -0.05 -0.17 N/A

TERT ENST00000296820.5 telomerase reverse transcriptase 10 1 0 0 1 3 hsa-miR-5001-5p -0.05 -0.06 N/A ArfGAP with GTPase domain, ankyrin repeat and PH AGAP1 ENST00000304032.8 109 3 0 3 0 5 hsa-miR-4498 -0.05 -0.08 N/A domain 1 CCDC93 ENST00000376300.2 coiled-coil domain containing 93 395 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.18 N/A

HEG1 ENST00000311127.4 heart development protein with EGF-like domains 1 380 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A

ADCY5 ENST00000462833.1 adenylate cyclase 5 25 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A myeloid/lymphoid or mixed-lineage leukemia (trithorax MLLT6 ENST00000325718.7 24 2 0 0 2 2 hsa-miR-5001-5p -0.05 -0.26 N/A homolog, Drosophila); translocated to, 6 KATNAL1 ENST00000380615.3 katanin p60 subunit A-like 1 335 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.11 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score DPY19L1 ENST00000310974.4 dpy-19-like 1 (C. elegans) 80 2 0 0 2 2 hsa-miR-5001-5p -0.05 -0.09 N/A

DIAPH2 ENST00000324765.8 diaphanous-related formin 2 91 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.06 N/A

CCDC127 ENST00000296824.3 coiled-coil domain containing 127 615 3 1 2 0 2 hsa-miR-4498 -0.05 -0.24 N/A

SENP8 ENST00000544411.1 SUMO/sentrin specific peptidase family member 8 80 1 0 1 0 1 hsa-miR-4498 -0.05 -0.28 N/A

FAM179A ENST00000379558.4 family with sequence similarity 179, member A 21 2 0 0 2 3 hsa-miR-5001-5p -0.05 -0.23 N/A GCN1 general control of amino-acid synthesis 1-like 1 GCN1L1 ENST00000300648.6 1283 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.06 N/A (yeast) CARHSP1 ENST00000396593.2 calcium regulated heat stable protein 1, 24kDa 113 1 1 0 0 2 hsa-miR-4498 -0.05 -0.52 N/A NRDE-2, necessary for RNA interference, domain NRDE2 ENST00000354366.3 30 3 1 2 0 0 hsa-miR-5001-5p -0.05 -0.35 N/A containing ARHGAP22 ENST00000249601.4 Rho GTPase activating protein 22 10 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.14 N/A

LONRF2 ENST00000393437.3 LON peptidase N-terminal domain and ring finger 2 394 2 0 1 1 3 hsa-miR-5001-5p -0.05 -0.06 N/A

BCORL1 ENST00000540052.1 BCL6 corepressor-like 1 209 2 0 2 0 2 hsa-miR-4498 -0.05 -0.12 N/A

RHPN1 ENST00000289013.6 rhophilin, Rho GTPase binding protein 1 97 2 0 2 0 2 hsa-miR-4498 -0.05 -0.16 N/A

GPR35 ENST00000319838.5 G protein-coupled receptor 35 71 3 2 1 0 1 hsa-miR-4498 -0.05 -0.34 N/A

LPHN3 ENST00000512091.2 latrophilin 3 93 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

GLP1R ENST00000373256.4 glucagon-like peptide 1 receptor 5 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A

PLA2G4E ENST00000399518.3 phospholipase A2, group IVE 5 1 0 1 0 1 hsa-miR-5001-5p -0.05 -0.05 N/A

MBOAT2 ENST00000305997.3 membrane bound O-acyltransferase domain containing 2 1145 1 0 1 0 1 hsa-miR-4498 -0.05 -0.17 N/A

CCDC160 ENST00000517294.1 coiled-coil domain containing 160 12 1 0 1 0 0 hsa-miR-4498 -0.05 -0.22 N/A

RHOBTB2 ENST00000251822.6 Rho-related BTB domain containing 2 32 3 0 1 2 2 hsa-miR-5001-5p -0.05 -0.07 N/A

ZNF527 ENST00000587349.1 zinc finger protein 527 86 1 1 0 0 0 hsa-miR-5001-5p -0.05 -0.19 N/A

ECD ENST00000372979.4 ecdysoneless homolog (Drosophila) 179 1 0 1 0 0 hsa-miR-4498 -0.05 -0.25 N/A

STK4 ENST00000372801.1 serine/threonine kinase 4 276 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.05 N/A

INADL ENST00000371158.2 InaD-like (Drosophila) 96 1 1 0 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A ATPase, aminophospholipid transporter, class I, type 8B, ATP8B2 ENST00000368489.3 244 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A member 2 KLHDC10 ENST00000335420.5 kelch domain containing 10 347 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.06 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score integrin, alpha X (complement component 3 receptor 4 ITGAX ENST00000268296.4 5 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A subunit) brain and reproductive organ-expressed (TNFRSF1A BRE ENST00000379632.2 880 2 0 2 0 2 hsa-miR-5001-5p -0.05 -0.52 N/A modulator) NCMAP ENST00000374392.2 noncompact myelin associated protein 17 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.19 N/A

SETD1A ENST00000262519.8 SET domain containing 1A 14 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.15 N/A

C11orf84 ENST00000294244.4 chromosome 11 open reading frame 84 232 1 0 1 0 2 hsa-miR-5001-5p -0.05 -0.22 N/A

MRPL45 ENST00000312513.5 mitochondrial ribosomal protein L45 49 2 1 1 0 1 hsa-miR-4498 -0.05 -0.56 N/A

C3orf70 ENST00000335012.2 chromosome 3 open reading frame 70 19 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.05 N/A down-regulator of transcription 1, TBP-binding (negative DR1 ENST00000370272.4 2994 1 0 1 0 2 hsa-miR-5001-5p -0.05 -0.29 N/A cofactor 2) SF3A2 ENST00000221494.5 splicing factor 3a, subunit 2, 66kDa 966 1 0 1 0 0 hsa-miR-4498 -0.05 -0.36 N/A

HARS ENST00000504156.1 histidyl-tRNA synthetase 34 2 0 2 0 1 hsa-miR-5001-5p -0.05 -0.38 N/A transforming growth factor, beta receptor associated protein TGFBRAP1 ENST00000393359.2 435 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.05 N/A 1 PHLPP2 ENST00000568954.1 PH domain and leucine rich repeat protein phosphatase 2 172 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A

TTBK2 ENST00000267890.6 tau tubulin kinase 2 18 2 0 0 2 1 hsa-miR-5001-5p -0.05 -0.1 N/A

BMP6 ENST00000283147.6 bone morphogenetic protein 6 1070 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

PSD3 ENST00000327040.8 pleckstrin and Sec7 domain containing 3 133 2 1 1 0 0 hsa-miR-4498 -0.05 -0.08 N/A

TMEM220 ENST00000341871.3 transmembrane protein 220 143 2 0 2 0 0 hsa-miR-4498 -0.05 -0.45 N/A

RALY ENST00000375114.3 RALY heterogeneous nuclear ribonucleoprotein 1489 4 1 2 1 1 hsa-miR-5001-5p -0.05 -0.73 N/A solute carrier family 9, subfamily A (NHE7, cation proton SLC9A7 ENST00000328306.4 147 2 1 0 1 0 hsa-miR-4498 -0.05 -0.27 N/A antiporter 7), member 7 transcription factor AP-2 beta (activating enhancer binding TFAP2B ENST00000393655.3 23 4 0 2 2 0 hsa-miR-4498 -0.05 -0.25 N/A protein 2 beta) NCBP1 ENST00000375147.3 nuclear cap binding protein subunit 1, 80kDa 746 1 0 1 0 0 hsa-miR-4498 -0.05 -0.08 N/A

TMEM179 ENST00000556573.1 transmembrane protein 179 5 2 0 2 0 3 hsa-miR-4498 -0.05 -0.45 N/A

TBL1XR1 ENST00000430069.1 transducin (beta)-like 1 X-linked receptor 1 334 1 1 0 0 0 hsa-miR-5001-5p -0.05 -0.25 N/A

PAPD7 ENST00000230859.6 PAP associated domain containing 7 3195 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

GPR85 ENST00000297146.3 G protein-coupled receptor 85 21 1 0 1 0 0 hsa-miR-4498 -0.05 -0.22 N/A Putative eukaryotic translation initiation factor 2 subunit 3- EIF2S3L ENST00000538173.1 8 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.13 N/A like protein Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GRAMD4 ENST00000361034.3 GRAM domain containing 4 403 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A solute carrier family 8 (sodium/calcium exchanger), member SLC8A1 ENST00000406785.2 61 5 1 1 3 2 hsa-miR-5001-5p -0.05 -0.26 N/A 1 TNPO3 ENST00000393245.1 transportin 3 30 1 0 0 1 3 hsa-miR-5001-5p -0.05 -0.11 N/A

ZNF668 ENST00000535577.1 zinc finger protein 668 124 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A

ADORA2A ENST00000337539.7 adenosine A2a receptor 337 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A

ZNF620 ENST00000314529.6 zinc finger protein 620 78 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A

SHANK3 ENST00000414786.2 SH3 and multiple ankyrin repeat domains 3 5 2 1 1 0 0 hsa-miR-4492 -0.05 -0.05 N/A

SCN8A ENST00000354534.6 sodium channel, voltage gated, type VIII, alpha subunit 44 2 1 1 0 0 hsa-miR-4492 -0.05 -0.05 N/A

DDX41 ENST00000507955.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 37 1 0 1 0 1 hsa-miR-4498 -0.05 -0.33 N/A sarcoglycan, delta (35kDa dystrophin-associated SGCD ENST00000435422.3 39 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.06 N/A glycoprotein) ZFPM1 ENST00000319555.3 zinc finger protein, FOG family member 1 168 3 1 2 0 1 hsa-miR-4498 -0.05 -0.61 N/A

KRBA1 ENST00000255992.10 KRAB-A domain containing 1 747 1 0 1 0 1 hsa-miR-4498 -0.05 -0.12 N/A

DTX3L ENST00000296161.4 deltex 3-like (Drosophila) 319 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A

UCP3 ENST00000314032.4 uncoupling protein 3 (mitochondrial, proton carrier) 10 1 0 1 0 1 hsa-miR-5001-5p -0.05 -0.23 N/A nudix (nucleoside diphosphate linked moiety X)-type motif NUDT16 ENST00000359850.3 622 1 0 0 1 2 hsa-miR-5001-5p -0.05 -0.12 N/A 16 TIGD5 ENST00000504548.2 tigger transposable element derived 5 823 2 0 1 1 2 hsa-miR-4498 -0.05 -0.47 N/A

MCAT ENST00000327555.5 malonyl CoA:ACP acyltransferase (mitochondrial) 133 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.21 N/A natriuretic peptide receptor C/guanylate cyclase C NPR3 ENST00000265074.8 517 2 0 0 2 1 hsa-miR-5001-5p -0.05 -0.13 N/A (atrionatriuretic peptide receptor C) DOCK3 ENST00000266037.9 dedicator of cytokinesis 3 47 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A

AKAP13 ENST00000394518.2 A kinase (PRKA) anchor protein 13 53 2 1 1 0 1 hsa-miR-5001-5p -0.05 -0.07 N/A carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) CHST15 ENST00000346248.5 59 1 0 0 1 2 hsa-miR-4498 -0.05 -0.05 N/A sulfotransferase 15 FAM129A ENST00000367511.3 family with sequence similarity 129, member A 213 2 1 1 0 2 hsa-miR-4492 -0.05 -0.05 N/A

CHCHD4 ENST00000295767.5 coiled-coil-helix-coiled-coil-helix domain containing 4 8 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.13 N/A

MRPS25 ENST00000253686.2 mitochondrial ribosomal protein S25 630 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.15 N/A

ZRANB3 ENST00000401392.1 zinc finger, RAN-binding domain containing 3 26 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score C1orf115 ENST00000294889.5 chromosome 1 open reading frame 115 180 1 0 0 1 0 hsa-miR-762 -0.05 -0.05 N/A

C15orf40 ENST00000304177.5 chromosome 15 open reading frame 40 133 3 0 2 1 0 hsa-miR-4498 -0.05 -0.8 N/A

C17orf85 ENST00000158149.3 chromosome 17 open reading frame 85 718 2 2 0 0 1 hsa-miR-4498 -0.05 -0.36 N/A

COBLL1 ENST00000375458.2 cordon-bleu WH2 repeat protein-like 1 70 2 1 1 0 0 hsa-miR-4498 -0.05 -0.42 N/A

ZNFX1 ENST00000371752.1 zinc finger, NFX1-type containing 1 41 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

ENTPD8 ENST00000344119.2 ectonucleoside triphosphate diphosphohydrolase 8 5 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A

C22orf46 ENST00000402966.1 chromosome 22 open reading frame 46 70 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A

RIMS3 ENST00000372684.3 regulating synaptic membrane exocytosis 3 24 3 0 1 2 2 hsa-miR-5001-5p -0.05 -0.15 N/A

ZNF708 ENST00000356929.3 zinc finger protein 708 16 1 0 0 1 1 hsa-miR-5001-5p -0.05 -0.28 N/A

ASB1 ENST00000264607.4 ankyrin repeat and SOCS box containing 1 408 2 0 1 1 2 hsa-miR-5001-5p -0.05 -0.11 N/A

NR1H2 ENST00000253727.5 nuclear receptor subfamily 1, group H, member 2 35 1 0 1 0 0 hsa-miR-4498 -0.05 -0.27 N/A

STX1B ENST00000215095.5 syntaxin 1B 26 3 0 2 1 1 hsa-miR-4498 -0.05 -0.22 N/A

MESDC2 ENST00000261758.4 mesoderm development candidate 2 1433 2 1 1 0 0 hsa-miR-4498 -0.05 -0.54 N/A

CBX5 ENST00000209875.4 chromobox homolog 5 360 1 0 1 0 3 hsa-miR-4498 -0.05 -0.09 N/A

TRIM2 ENST00000338700.5 tripartite motif containing 2 22 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A

KIF13B ENST00000524189.1 kinesin family member 13B 17 1 0 1 0 1 hsa-miR-4498 -0.05 -0.05 N/A

CENPL ENST00000356198.2 centromere protein L 390 1 1 0 0 0 hsa-miR-5001-5p -0.05 -0.35 N/A

CCDC88C ENST00000389857.6 coiled-coil domain containing 88C 42 1 0 1 0 0 hsa-miR-4498 -0.05 -0.05 N/A

UBE2F ENST00000272930.4 ubiquitin-conjugating enzyme E2F (putative) 905 2 0 0 2 0 hsa-miR-5001-5p -0.05 -0.13 N/A

GSC2 ENST00000086933.2 goosecoid homeobox 2 5 1 0 1 0 1 hsa-miR-5001-5p -0.05 -0.07 N/A

PTPRE ENST00000254667.3 protein tyrosine phosphatase, receptor type, E 44 1 0 0 1 1 hsa-miR-4498 -0.05 -0.14 N/A potassium voltage-gated channel, subfamily H (eag-related), KCNH5 ENST00000322893.7 157 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.06 N/A member 5 TKT ENST00000462138.1 transketolase 1351 1 0 1 0 1 hsa-miR-5001-5p -0.05 -0.16 N/A

ZNF470 ENST00000330619.8 zinc finger protein 470 12 2* 0 1 0 0 hsa-miR-4498 -0.05 -0.11 N/A

CENPI ENST00000372927.1 centromere protein I 379 2 1 1 0 0 hsa-miR-4498 -0.05 -0.36 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GBP2 ENST00000370466.3 guanylate binding protein 2, interferon-inducible 1309 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

CCDC149 ENST00000428116.2 coiled-coil domain containing 149 187 2 0 1 1 1 hsa-miR-4498 -0.05 -0.14 N/A

PDE12 ENST00000311180.8 phosphodiesterase 12 326 1 0 1 0 1 hsa-miR-5001-5p -0.05 -0.19 N/A

EBF4 ENST00000380648.4 early B-cell factor 4 1194 2 0 1 1 2 hsa-miR-5001-5p -0.05 -0.31 N/A

ZNF831 ENST00000371030.2 zinc finger protein 831 5 1 0 1 0 0 hsa-miR-5001-5p -0.05 -0.05 N/A

EIF2AK2 ENST00000233057.4 eukaryotic translation initiation factor 2-alpha kinase 2 292 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.08 N/A

CNTNAP2 ENST00000361727.3 contactin associated protein-like 2 29 1 0 1 0 0 hsa-miR-4498 -0.05 -0.06 N/A NACC family member 2, BEN and BTB (POZ) domain NACC2 ENST00000371753.1 172 2 1 1 0 3 hsa-miR-762 -0.05 -0.07 N/A containing TOLLIP ENST00000317204.6 toll interacting protein 1536 1 0 1 0 1 hsa-miR-4498 -0.05 -0.21 N/A

INCENP ENST00000394818.3 inner centromere protein antigens 135/155kDa 1299 2 0 2 0 0 hsa-miR-5001-5p -0.05 -0.1 N/A

LANCL1 ENST00000443314.1 LanC lantibiotic synthetase component C-like 1 (bacterial) 3395 1 0 0 1 0 hsa-miR-5001-5p -0.05 -0.05 N/A

IBA57 ENST00000366711.3 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae) 66 1 0 1 0 5 hsa-miR-5001-5p -0.05 -0.28 N/A

MCF2L ENST00000397030.1 MCF.2 cell line derived transforming sequence-like 79 2 0 1 1 1 hsa-miR-4498 -0.05 -0.08 N/A

OSM ENST00000215781.2 oncostatin M 5 1 0 1 0 1 hsa-miR-5001-5p -0.04 -0.04 N/A

ABL2 ENST00000502732.1 c-abl oncogene 2, non-receptor tyrosine kinase 892 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.05 N/A

TMEM37 ENST00000306406.4 transmembrane protein 37 2076 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.2 N/A

RHOB ENST00000272233.4 ras homolog family member B 6532 1 0 1 0 0 hsa-miR-4498 -0.04 -0.04 N/A

HMSD ENST00000408945.3 histocompatibility (minor) serpin domain containing 11 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.23 N/A

NUB1 ENST00000413040.2 negative regulator of ubiquitin-like proteins 1 85 1 0 1 0 0 hsa-miR-4498 -0.04 -0.17 N/A

NAT10 ENST00000257829.3 N-acetyltransferase 10 (GCN5-related) 132 1 1 0 0 3 hsa-miR-5001-5p -0.04 -0.12 N/A

ZBTB40 ENST00000404138.1 zinc finger and BTB domain containing 40 124 2 0 2 0 1 hsa-miR-4498 -0.04 -0.15 N/A

MR1 ENST00000367580.5 major histocompatibility complex, class I-related 107 2 2 0 0 2 hsa-miR-5001-5p -0.04 -0.25 N/A phosphoribosylaminoimidazole carboxylase, PAICS ENST00000264221.2 3895 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.31 N/A phosphoribosylaminoimidazole succinocarboxamide KLHL30 ENST00000409223.1 kelch-like family member 30 5 2 0 2 0 1 hsa-miR-4498 -0.04 -0.06 N/A

C7orf65 ENST00000408988.2 chromosome 7 open reading frame 65 5 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CALR ENST00000316448.5 calreticulin 17017 1 0 0 1 1 hsa-miR-4498 -0.04 -0.12 N/A

PQLC2 ENST00000375155.3 PQ loop repeat containing 2 94 3 0 2 1 3 hsa-miR-4498 -0.04 -0.43 N/A

FBXO25 ENST00000276326.5 F-box protein 25 157 2 0 0 2 1 hsa-miR-5001-5p -0.04 -0.14 N/A

RHBDL3 ENST00000269051.4 rhomboid, veinlet-like 3 (Drosophila) 100 3 1 1 1 0 hsa-miR-5001-5p -0.04 -0.45 N/A

YTHDF3 ENST00000539294.1 YTH domain family, member 3 444 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.09 N/A

ZNF324B ENST00000336614.4 zinc finger protein 324B 19 1 1 0 0 2 hsa-miR-5001-5p -0.04 -0.18 N/A

BAK1 ENST00000442998.2 BCL2-antagonist/killer 1 15 1 0 0 1 3 hsa-miR-5001-5p -0.04 -0.05 N/A

SFT2D2 ENST00000271375.4 SFT2 domain containing 2 97 2 0 1 1 1 hsa-miR-4498 -0.04 -0.18 N/A

STAMBP ENST00000394070.2 STAM binding protein 1274 3 2 0 1 0 hsa-miR-5001-5p -0.04 -0.43 N/A

ELMO1 ENST00000341056.3 engulfment and cell motility 1 118 1 0 1 0 2 hsa-miR-4498 -0.04 -0.18 N/A ARP1 actin-related protein 1 homolog B, centractin beta ACTR1B ENST00000289228.5 5716 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A (yeast) FAM171A1 ENST00000378116.4 family with sequence similarity 171, member A1 20 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.04 N/A

CYB5R1 ENST00000367249.4 cytochrome b5 reductase 1 545 1 0 1 0 1 hsa-miR-5001-5p -0.04 -0.31 N/A

MFSD12 ENST00000398558.4 major facilitator superfamily domain containing 12 6 1 0 1 0 3 hsa-miR-4498 -0.04 -0.24 N/A

PMPCA ENST00000371717.3 peptidase (mitochondrial processing) alpha 105 3 2 1 0 1 hsa-miR-5001-5p -0.04 -0.64 N/A TATA box binding protein (TBP)-associated factor, RNA TAF1B ENST00000263663.5 214 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.09 N/A polymerase I, B, 63kDa TACC1 ENST00000330691.6 transforming, acidic coiled-coil containing protein 1 186 1 0 0 1 2 hsa-miR-4498 -0.04 -0.13 N/A

EFCAB2 ENST00000366523.1 EF-hand calcium binding domain 2 204 1 0 1 0 0 hsa-miR-4498 -0.04 -0.18 N/A

HAUS5 ENST00000379045.2 HAUS augmin-like complex, subunit 5 133 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.18 N/A

PAIP2B ENST00000244221.8 poly(A) binding protein interacting protein 2B 42 2 0 0 2 1 hsa-miR-5001-5p -0.04 -0.22 N/A

NONO ENST00000276079.8 non-POU domain containing, octamer-binding 177 1 0 1 0 0 hsa-miR-4498 -0.04 -0.21 N/A coagulation factor VII (serum prothrombin conversion F7 ENST00000375581.3 458 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.05 N/A accelerator) TOM1L1 ENST00000575333.1 target of myb1 (chicken)-like 1 176 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.18 N/A

ELP2 ENST00000358232.6 elongator acetyltransferase complex subunit 2 845 1 0 1 0 2 hsa-miR-4498 -0.04 -0.09 N/A

FAM81A ENST00000288228.5 family with sequence similarity 81, member A 53 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score KIAA1462 ENST00000375377.1 KIAA1462 360 1 0 1 0 1 hsa-miR-4498 -0.04 -0.09 N/A

TXLNG ENST00000380122.5 taxilin gamma 96 2 1 0 1 0 hsa-miR-5001-5p -0.04 -0.39 N/A

IFNE ENST00000448696.3 interferon, epsilon 65 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.15 N/A

DVL3 ENST00000313143.3 dishevelled segment polarity protein 3 373 1 0 1 0 2 hsa-miR-5001-5p -0.04 -0.19 N/A ganglioside induced differentiation associated protein 1-like GDAP1L1 ENST00000342560.5 28 1 1 0 0 2 hsa-miR-5001-5p -0.04 -0.26 N/A 1 ZNF747 ENST00000395094.3 zinc finger protein 747 101 1 0 0 1 3 hsa-miR-5001-5p -0.04 -0.18 N/A

ZBTB7B ENST00000368426.3 zinc finger and BTB domain containing 7B 179 1 0 1 0 1 hsa-miR-5001-5p -0.04 -0.06 N/A

UGGT1 ENST00000259253.6 UDP-glucose glycoprotein glucosyltransferase 1 1377 1 0 1 0 1 hsa-miR-4498 -0.04 -0.1 N/A

MESP1 ENST00000300057.4 mesoderm posterior 1 homolog (mouse) 303 1 0 1 0 1 hsa-miR-4498 -0.04 -0.25 N/A

ZDHHC7 ENST00000313732.4 zinc finger, DHHC-type containing 7 4068 2 0 2 0 1 hsa-miR-4498 -0.04 -0.1 N/A

NUDCD3 ENST00000355451.7 NudC domain containing 3 659 1 0 0 1 1 hsa-miR-762 -0.04 -0.13 N/A

PDHA1 ENST00000379806.5 pyruvate dehydrogenase (lipoamide) alpha 1 4824 1 0 1 0 0 hsa-miR-4498 -0.04 -0.15 N/A

SORCS2 ENST00000507866.2 sortilin-related VPS10 domain containing receptor 2 85 1 0 1 0 2 hsa-miR-4498 -0.04 -0.04 N/A

GJA3 ENST00000241125.3 gap junction protein, alpha 3, 46kDa 244 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.04 N/A

MEGF8 ENST00000334370.4 multiple EGF-like-domains 8 28 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A

CNTNAP3B ENST00000377564.3 contactin associated protein-like 3B 5 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A

ARHGEF5 ENST00000056217.5 Rho guanine nucleotide exchange factor (GEF) 5 200 1 0 1 0 1 hsa-miR-4498 -0.04 -0.29 N/A NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa NDUFS1 ENST00000233190.6 1041 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.19 N/A (NADH-coenzyme Q reductase) CYP7B1 ENST00000310193.3 cytochrome P450, family 7, subfamily B, polypeptide 1 53 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A

CARF ENST00000402905.3 calcium responsive transcription factor 27 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.14 N/A

KCTD16 ENST00000507359.3 potassium channel tetramerization domain containing 16 36 1 1 0 0 2 hsa-miR-5001-5p -0.04 -0.21 N/A

FAM199X ENST00000493442.1 family with sequence similarity 199, X-linked 856 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.06 N/A

CYP27B1 ENST00000228606.4 cytochrome P450, family 27, subfamily B, polypeptide 1 11 1 1 0 0 0 hsa-miR-5001-5p -0.04 -0.15 N/A

RAB11FIP4 ENST00000325874.8 RAB11 family interacting protein 4 (class II) 169 1 0 1 0 3 hsa-miR-5001-5p -0.04 -0.1 N/A Uncharacterized protein; cDNA FLJ45526 fis, clone AC010536.1 ENST00000538868.1 18 1 0 1 0 0 hsa-miR-4498 -0.04 -0.15 N/A BRTHA2027227 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TRIOBP ENST00000406386.3 TRIO and F-actin binding protein 1545 1 0 1 0 0 hsa-miR-4498 -0.04 -0.08 N/A

KIAA0141 ENST00000194118.4 KIAA0141 1078 1 0 1 0 1 hsa-miR-4498 -0.04 -0.28 N/A

CCDC103 ENST00000417826.2 coiled-coil domain containing 103 72 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.1 N/A

PCDHA10 ENST00000307360.5 protocadherin alpha 10 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA5 ENST00000529859.1 protocadherin alpha 5 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA7 ENST00000525929.1 protocadherin alpha 7 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

HECTD4 ENST00000377560.5 HECT domain containing E3 ubiquitin protein ligase 4 222 2 0 2 0 2 hsa-miR-4492 -0.04 -0.04 N/A

PCDHA4 ENST00000530339.1 protocadherin alpha 4 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA12 ENST00000398631.2 protocadherin alpha 12 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

ZNF862 ENST00000223210.4 zinc finger protein 862 7 2 0 2 0 3 hsa-miR-4492 -0.04 -0.04 N/A

PCDHA2 ENST00000526136.1 protocadherin alpha 2 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

FBN1 ENST00000316623.5 fibrillin 1 798 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.12 N/A

SSH2 ENST00000582084.1 slingshot protein phosphatase 2 190 1 0 1 0 1 hsa-miR-4498 -0.04 -0.42 N/A calcium/calmodulin-dependent serine protein kinase CASK ENST00000421587.2 892 2 1 0 1 1 hsa-miR-5001-5p -0.04 -0.11 N/A (MAGUK family) UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- GALNT2 ENST00000366672.4 2834 2 0 1 1 1 hsa-miR-5001-5p -0.04 -0.14 N/A acetylgalactosaminyltransferase 2 (GalNAc-T2) MFSD1 ENST00000415822.2 major facilitator superfamily domain containing 1 257 1 1 0 0 0 hsa-miR-5001-5p -0.04 -0.29 N/A

AMDHD2 ENST00000302956.4 amidohydrolase domain containing 2 488 2 0 0 2 1 hsa-miR-5001-5p -0.04 -0.11 N/A

TRMT2A ENST00000404751.3 tRNA methyltransferase 2 homolog A (S. cerevisiae) 455 1 0 0 1 1 hsa-miR-4498 -0.04 -0.14 N/A

ATRX ENST00000373344.5 alpha thalassemia/mental retardation syndrome X-linked 77 1 0 1 0 0 hsa-miR-4498 -0.04 -0.15 N/A

TIMP4 ENST00000287814.4 TIMP metallopeptidase inhibitor 4 38 3 0 2 1 0 hsa-miR-5001-5p -0.04 -0.28 N/A

ZNF134 ENST00000396161.5 zinc finger protein 134 184 1 0 0 1 0 hsa-miR-4498 -0.04 -0.14 N/A

VASN ENST00000304735.3 vasorin 192 3 0 2 1 4 hsa-miR-4498 -0.04 -0.19 N/A

MOCOS ENST00000261326.5 molybdenum cofactor sulfurase 627 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA6 ENST00000529310.1 protocadherin alpha 6 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA3 ENST00000522353.2 protocadherin alpha 3 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score DYNLL2 ENST00000579991.2 dynein, light chain, LC8-type 2 1162 1 0 1 0 1 hsa-miR-4498 -0.04 -0.21 N/A

PCDHAC1 ENST00000253807.2 protocadherin alpha subfamily C, 1 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA11 ENST00000398640.2 protocadherin alpha 11 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA13 ENST00000289272.2 protocadherin alpha 13 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA9 ENST00000532602.1 protocadherin alpha 9 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA1 ENST00000504120.2 protocadherin alpha 1 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

PCDHA8 ENST00000531613.1 protocadherin alpha 8 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A excision repair cross-complementing rodent repair ERCC6 ENST00000355832.5 93 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.15 N/A deficiency, complementation group 6 SNRPD3 ENST00000215829.3 small nuclear ribonucleoprotein D3 polypeptide 18kDa 3251 1 0 1 0 0 hsa-miR-4498 -0.04 -0.26 N/A

GXYLT2 ENST00000389617.4 glucoside xylosyltransferase 2 207 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.13 N/A

SOCS4 ENST00000395472.2 suppressor of cytokine signaling 4 336 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.07 N/A

KIAA1432 ENST00000414202.2 KIAA1432 1366 2 0 0 2 0 hsa-miR-5001-5p -0.04 -0.08 N/A RAS guanyl releasing protein 3 (calcium and DAG- RASGRP3 ENST00000402538.3 24 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.08 N/A regulated) TEX22 ENST00000451127.2 testis expressed 22 9 1 0 1 0 1 hsa-miR-4498 -0.04 -0.06 N/A

RWDD1 ENST00000466444.2 RWD domain containing 1 296 1 0 1 0 1 hsa-miR-4498 -0.04 -0.22 N/A

VPS26B ENST00000281187.5 vacuolar protein sorting 26 homolog B (S. pombe) 1236 1 0 1 0 0 hsa-miR-4498 -0.04 -0.04 N/A

DDIT4 ENST00000307365.3 DNA-damage-inducible transcript 4 2454 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

CDK10 ENST00000353379.7 cyclin-dependent kinase 10 1167 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

RUNX1 ENST00000344691.4 runt-related transcription factor 1 182 1 0 1 0 0 hsa-miR-4498 -0.04 -0.12 N/A

ZBTB12 ENST00000375527.2 zinc finger and BTB domain containing 12 18 2 0 2 0 0 hsa-miR-4498 -0.04 -0.32 N/A

SLC35F5 ENST00000245680.2 solute carrier family 35, member F5 136 1 1 0 0 0 hsa-miR-4498 -0.04 -0.37 N/A

CORO2A ENST00000343933.5 coronin, actin binding protein, 2A 493 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.25 N/A

PSMF1 ENST00000335877.6 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2709 3 0 3 0 2 hsa-miR-5001-5p -0.04 -0.5 N/A

ADCY2 ENST00000338316.4 adenylate cyclase 2 (brain) 13 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.1 N/A

CCDC77 ENST00000239830.4 coiled-coil domain containing 77 8 1 1 0 0 1 hsa-miR-5001-5p -0.04 -0.22 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM251 ENST00000415050.2 transmembrane protein 251 14 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.19 N/A

CARM1 ENST00000327064.4 coactivator-associated arginine methyltransferase 1 663 2 0 2 0 1 hsa-miR-4492 -0.04 -0.04 N/A

C9orf3 ENST00000297979.5 chromosome 9 open reading frame 3 1591 3 2 0 1 3 hsa-miR-4498 -0.04 -0.25 N/A

YY1 ENST00000262238.4 YY1 transcription factor 1803 2 0 1 1 1 hsa-miR-5001-5p -0.04 -0.06 N/A

PCDHAC2 ENST00000289269.5 protocadherin alpha subfamily C, 2 86 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.04 N/A

SOCS2 ENST00000548537.1 suppressor of cytokine signaling 2 89 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.04 N/A

TACR1 ENST00000305249.5 tachykinin receptor 1 5 1 0 1 0 2 hsa-miR-4498 -0.04 -0.04 N/A

ARFIP2 ENST00000254584.2 ADP-ribosylation factor interacting protein 2 798 1 1 0 0 1 hsa-miR-4498 -0.04 -0.3 N/A

TUBGCP4 ENST00000564079.1 tubulin, gamma complex associated protein 4 129 1 0 1 0 0 hsa-miR-4498 -0.04 -0.18 N/A

TMEM186 ENST00000333050.6 transmembrane protein 186 287 1 0 1 0 0 hsa-miR-4498 -0.04 -0.33 N/A

GOLGA7B ENST00000370602.1 golgin A7 family, member B 5 2 0 1 1 4 hsa-miR-5001-5p -0.04 -0.43 N/A

RPH3AL ENST00000331302.7 rabphilin 3A-like (without C2 domains) 60 1 1 0 0 1 hsa-miR-4498 -0.04 -0.14 N/A

SETD5 ENST00000402198.1 SET domain containing 5 48 1 1 0 0 0 hsa-miR-5001-5p -0.04 -0.06 N/A

IL17RA ENST00000319363.6 interleukin 17 receptor A 685 3* 1 1 0 4 hsa-miR-4498 -0.04 -0.4 N/A

ZNF417 ENST00000312026.5 zinc finger protein 417 19 1 0 1 0 1 hsa-miR-4498 -0.04 -0.11 N/A

BMP8A ENST00000331593.5 bone morphogenetic protein 8a 13 1 0 0 1 2 hsa-miR-4498 -0.04 -0.06 N/A

KIAA1551 ENST00000312561.4 KIAA1551 15 1 1 0 0 1 hsa-miR-5001-5p -0.04 -0.43 N/A

DIP2C ENST00000280886.6 DIP2 disco-interacting protein 2 homolog C (Drosophila) 359 1 0 1 0 0 hsa-miR-4498 -0.04 -0.05 N/A

SLC26A11 ENST00000361193.3 solute carrier family 26 (anion exchanger), member 11 115 1 0 1 0 0 hsa-miR-4498 -0.04 -0.04 N/A

NCAM1 ENST00000316851.7 neural cell adhesion molecule 1 19 1 0 1 0 2 hsa-miR-5001-5p -0.04 -0.14 N/A

HIC2 ENST00000407464.2 hypermethylated in cancer 2 28 2 0 2 0 3 hsa-miR-5001-5p -0.04 -0.11 N/A

TNFAIP2 ENST00000560869.1 tumor necrosis factor, alpha-induced protein 2 442 1 0 0 1 1 hsa-miR-4498 -0.04 -0.04 N/A

PATZ1 ENST00000405309.3 POZ (BTB) and AT hook containing zinc finger 1 165 1 0 0 1 1 hsa-miR-5001-5p -0.04 -0.04 N/A

NAA10 ENST00000370015.4 N(alpha)-acetyltransferase 10, NatA catalytic subunit 960 1 0 0 1 0 hsa-miR-4498 -0.04 -0.26 N/A

WDR73 ENST00000434634.2 WD repeat domain 73 117 2 0 1 1 1 hsa-miR-4498 -0.04 -0.53 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RIMKLA ENST00000431473.3 ribosomal modification protein rimK-like family member A 100 1 0 1 0 2 hsa-miR-4498 -0.04 -0.18 N/A

SPTY2D1 ENST00000336349.5 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 241 1 0 0 1 0 hsa-miR-5001-5p -0.04 -0.15 N/A

ERI2 ENST00000569729.1 ERI1 exoribonuclease family member 2 96 1 0 1 0 0 hsa-miR-5001-5p -0.04 -0.21 N/A

MITF ENST00000328528.6 microphthalmia-associated transcription factor 593 1 0 0 1 1 hsa-miR-4498 -0.04 -0.09 N/A

ATE1 ENST00000369043.3 arginyltransferase 1 237 1 0 1 0 0 hsa-miR-4498 -0.04 -0.04 N/A

ABL1 ENST00000318560.5 c-abl oncogene 1, non-receptor tyrosine kinase 1188 1 0 1 0 0 hsa-miR-4498 -0.04 -0.04 N/A

DLGAP3 ENST00000373347.1 discs, large (Drosophila) homolog-associated protein 3 8 1 0 1 0 2 hsa-miR-5001-5p -0.04 -0.04 N/A

GABRQ ENST00000370306.2 gamma-aminobutyric acid (GABA) A receptor, theta 14 1 0 1 0 0 hsa-miR-4498 -0.04 -0.1 N/A

DSC3 ENST00000434452.1 desmocollin 3 390 1 0 0 1 1 hsa-miR-4498 -0.03 -0.04 N/A solute carrier family 25 (aspartate/glutamate carrier), SLC25A12 ENST00000422440.2 566 1 0 1 0 2 hsa-miR-5001-5p -0.03 -0.07 N/A member 12 GZF1 ENST00000338121.5 GDNF-inducible zinc finger protein 1 252 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.14 N/A

HDX ENST00000297977.5 highly divergent homeobox 20 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.05 N/A solute carrier family 4, sodium bicarbonate cotransporter, SLC4A8 ENST00000453097.2 17 1 0 0 1 3 hsa-miR-5001-5p -0.03 -0.05 N/A member 8 TBC1D20 ENST00000354200.4 TBC1 domain family, member 20 761 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.1 N/A

WNT11 ENST00000322563.3 wingless-type MMTV integration site family, member 11 59 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.18 N/A

C1orf21 ENST00000235307.6 chromosome 1 open reading frame 21 935 4 1 1 2 3 hsa-miR-5001-5p -0.03 -0.42 N/A

GTPBP10 ENST00000222511.6 GTP-binding protein 10 (putative) 489 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.31 N/A

PDE1C ENST00000396193.1 phosphodiesterase 1C, calmodulin-dependent 70kDa 106 1 0 0 1 1 hsa-miR-5001-5p -0.03 -0.03 N/A

ZNF85 ENST00000328178.8 zinc finger protein 85 35 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.06 N/A

DRAM1 ENST00000258534.8 DNA-damage regulated autophagy modulator 1 4884 1 0 0 1 2 hsa-miR-5001-5p -0.03 -0.04 N/A

PLA2R1 ENST00000283243.7 phospholipase A2 receptor 1, 180kDa 41 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.08 N/A

FNIP2 ENST00000264433.6 folliculin interacting protein 2 266 1 0 0 1 0 hsa-miR-4498 -0.03 -0.05 N/A

TMEM120B ENST00000449592.2 transmembrane protein 120B 60 2 0 1 1 4 hsa-miR-4498 -0.03 -0.09 N/A

CNKSR3 ENST00000607772.1 CNKSR family member 3 567 5 0 1 4 1 hsa-miR-5001-5p -0.03 -0.68 N/A

VIPR2 ENST00000262178.2 vasoactive intestinal peptide receptor 2 35 1 0 1 0 3 hsa-miR-5001-5p -0.03 -0.08 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score CENPM ENST00000404067.1 centromere protein M 68 2 0 1 1 2 hsa-miR-4498 -0.03 -0.51 N/A

PTPN9 ENST00000306726.2 protein tyrosine phosphatase, non-receptor type 9 644 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.28 N/A

FREM2 ENST00000280481.7 FRAS1 related extracellular matrix protein 2 33 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.06 N/A

SH3RF3 ENST00000309415.6 SH3 domain containing ring finger 3 15 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

NBPF15 ENST00000442702.2 neuroblastoma breakpoint family, member 15 5 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

BMPR1A ENST00000372037.3 bone morphogenetic protein receptor, type IA 125 2 1 0 1 0 hsa-miR-5001-5p -0.03 -0.18 N/A

CTD-2545M3.6 ENST00000599632.1 10 2 1 1 0 1 hsa-miR-4498 -0.03 -0.49 N/A solute carrier family 2 (facilitated glucose transporter), SLC2A14 ENST00000340749.5 14 1 0 0 1 1 hsa-miR-4498 -0.03 -0.09 N/A member 14 SEPT8 ENST00000378706.1 septin 8 199 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.07 N/A

TUBA8 ENST00000330423.3 tubulin, alpha 8 28 2 0 1 1 0 hsa-miR-5001-5p -0.03 -0.19 N/A

ZDHHC24 ENST00000310442.3 zinc finger, DHHC-type containing 24 304 1 1 0 0 1 hsa-miR-5001-5p -0.03 -0.22 N/A

NELFB ENST00000343053.4 negative elongation factor complex member B 1686 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

ZNF436 ENST00000314011.4 zinc finger protein 436 73 1 0 1 0 1 hsa-miR-4498 -0.03 -0.15 N/A

TRIO ENST00000344204.4 trio Rho guanine nucleotide exchange factor 365 1 0 1 0 0 hsa-miR-4498 -0.03 -0.09 N/A

PACS2 ENST00000447393.1 phosphofurin acidic cluster sorting protein 2 234 4 0 3 1 3 hsa-miR-4498 -0.03 -0.34 N/A

FGD4 ENST00000427716.2 FYVE, RhoGEF and PH domain containing 4 38 1 0 1 0 0 hsa-miR-4498 -0.03 -0.06 N/A

SHROOM1 ENST00000378679.3 shroom family member 1 150 1 0 1 0 0 hsa-miR-4498 -0.03 -0.14 N/A

PIP4K2B ENST00000269554.3 phosphatidylinositol-5-phosphate 4-kinase, type II, beta 148 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.04 N/A

NBPF10 ENST00000369339.3 neuroblastoma breakpoint family, member 10 5 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

NBPF16 ENST00000417839.1 neuroblastoma breakpoint family, member 16 5 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

EIF4B ENST00000262056.9 eukaryotic translation initiation factor 4B 37 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.03 N/A

TRAK1 ENST00000341421.3 trafficking protein, kinesin binding 1 362 1 0 1 0 0 hsa-miR-4498 -0.03 -0.03 N/A

CDKN2AIPNL ENST00000458198.2 CDKN2A interacting protein N-terminal like 133 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.43 N/A

GJB1 ENST00000374022.3 gap junction protein, beta 1, 32kDa 96 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.14 N/A

CALM1 ENST00000356978.4 calmodulin 1 (phosphorylase kinase, delta) 4046 2 1 0 1 0 hsa-miR-4498 -0.03 -0.26 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AGO2 ENST00000220592.5 argonaute RISC catalytic component 2 350 1 0 1 0 0 hsa-miR-4498 -0.03 -0.62 N/A

HS2ST1 ENST00000370550.5 heparan sulfate 2-O-sulfotransferase 1 787 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

OPCML ENST00000331898.7 opioid binding protein/cell adhesion molecule-like 5 1 1 0 0 0 hsa-miR-4492 -0.03 -0.03 N/A

KIFC3 ENST00000465878.2 kinesin family member C3 65 1 0 1 0 1 hsa-miR-5001-5p -0.03 -0.03 N/A

NUP210 ENST00000254508.5 nucleoporin 210kDa 246 1 1 0 0 0 hsa-miR-4492 -0.03 -0.03 N/A

SULF1 ENST00000458141.2 sulfatase 1 11 2 0 1 1 0 hsa-miR-4492 -0.03 -0.03 N/A

KIAA1875 ENST00000323662.8 KIAA1875 5 1 1 0 0 1 hsa-miR-4492 -0.03 -0.03 N/A

PDXK ENST00000468090.1 pyridoxal (pyridoxine, vitamin B6) kinase 5653 2 0 1 1 3 hsa-miR-4498 -0.03 -0.19 N/A

PRMT6 ENST00000370078.1 protein arginine methyltransferase 6 270 2 1 0 1 1 hsa-miR-4498 -0.03 -0.27 N/A

ZNF576 ENST00000336564.4 zinc finger protein 576 786 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.66 N/A

PUM2 ENST00000338086.5 pumilio RNA-binding family member 2 1047 1 0 0 1 1 hsa-miR-5001-5p -0.03 -0.07 N/A

MRPS11 ENST00000325844.4 mitochondrial ribosomal protein S11 1452 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.37 N/A

DNMT3A ENST00000380746.4 DNA (cytosine-5-)-methyltransferase 3 alpha 221 1 0 1 0 4 hsa-miR-4498 -0.03 -0.21 N/A

ADAT2 ENST00000606514.1 adenosine deaminase, tRNA-specific 2 303 2 0 1 1 1 hsa-miR-5001-5p -0.03 -0.22 N/A

RBP2 ENST00000232217.2 retinol binding protein 2, cellular 46 1 1 0 0 2 hsa-miR-4498 -0.03 -0.33 N/A

PLXND1 ENST00000393239.1 plexin D1 211 2 0 1 1 0 hsa-miR-4492 -0.03 -0.03 N/A

CNTNAP3 ENST00000297668.6 contactin associated protein-like 3 5 1 0 0 1 1 hsa-miR-5001-5p -0.03 -0.06 N/A

RCE1 ENST00000309657.3 RCE1 homolog, prenyl protein protease (S. cerevisiae) 4698 1 0 1 0 1 hsa-miR-5001-5p -0.03 -0.03 N/A

GABRA4 ENST00000264318.3 gamma-aminobutyric acid (GABA) A receptor, alpha 4 5 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

MYOCD ENST00000425538.1 myocardin 62 1 0 1 0 2 hsa-miR-4498 -0.03 -0.03 N/A

RFTN2 ENST00000295049.4 raftlin family member 2 21 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.12 N/A

RGS5 ENST00000313961.5 regulator of G-protein signaling 5 56 1 0 1 0 0 hsa-miR-4498 -0.03 -0.23 N/A

MTR ENST00000366577.5 5-methyltetrahydrofolate-homocysteine methyltransferase 378 1 0 1 0 2 hsa-miR-4498 -0.03 -0.06 N/A

VPS18 ENST00000220509.5 vacuolar protein sorting 18 homolog (S. cerevisiae) 295 6 1 5 0 3 hsa-miR-4498 -0.03 -0.74 N/A

METTL21A ENST00000448823.2 methyltransferase like 21A 224 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.08 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score AATK ENST00000326724.4 apoptosis-associated tyrosine kinase 307 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

FRAS1 ENST00000264895.6 Fraser syndrome 1 709 1 0 1 0 0 hsa-miR-4498 -0.03 -0.03 N/A pleckstrin homology domain containing, family G (with PLEKHG5 ENST00000377725.1 284 2 0 1 1 1 hsa-miR-4498 -0.03 -0.15 N/A RhoGef domain) member 5 HEXA ENST00000268097.5 hexosaminidase A (alpha polypeptide) 209 2 0 0 2 1 hsa-miR-5001-5p -0.03 -0.22 N/A

LRRC46 ENST00000269025.4 leucine rich repeat containing 46 90 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.35 N/A

GAREM ENST00000399218.4 GRB2 associated, regulator of MAPK1 536 1 0 0 1 2 hsa-miR-4498 -0.03 -0.04 N/A

SOCS7 ENST00000577233.1 suppressor of cytokine signaling 7 15 3 0 2 1 4 hsa-miR-4498 -0.03 -0.12 N/A

KNSTRN ENST00000608100.1 kinetochore-localized astrin/SPAG5 binding protein 1628 1 0 1 0 3 hsa-miR-4498 -0.03 -0.24 N/A

ENDOD1 ENST00000278505.4 endonuclease domain containing 1 100 3 1 2 0 1 hsa-miR-4498 -0.03 -0.28 N/A

TMPPE ENST00000416695.2 transmembrane protein with metallophosphoesterase domain 22 1 0 1 0 0 hsa-miR-4498 -0.03 -0.1 N/A serpin peptidase inhibitor, clade E (nexin, plasminogen SERPINE1 ENST00000223095.4 1508 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.24 N/A activator inhibitor type 1), member 1 CCDC90B ENST00000529689.1 coiled-coil domain containing 90B 173 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.27 N/A

USP6NL ENST00000609104.1 USP6 N-terminal like 183 2 2 0 0 1 hsa-miR-5001-5p -0.03 -0.2 N/A UDP-GlcNAc:betaGal beta-1,3-N- B3GNT6 ENST00000533140.1 5 1 0 0 1 2 hsa-miR-4498 -0.03 -0.14 N/A acetylglucosaminyltransferase 6 (core 3 synthase) GNG4 ENST00000450593.1 guanine nucleotide binding protein (G protein), gamma 4 1171 1 0 1 0 2 hsa-miR-5001-5p -0.03 -0.23 N/A

FOXO3 ENST00000343882.6 forkhead box O3 32 1 0 1 0 0 hsa-miR-4498 -0.03 -0.03 N/A

AGPAT5 ENST00000285518.6 1-acylglycerol-3-phosphate O-acyltransferase 5 879 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.04 N/A

FASN ENST00000306749.2 fatty acid synthase 37 1 0 1 0 2 hsa-miR-4498 -0.03 -0.05 N/A

USP31 ENST00000219689.7 ubiquitin specific peptidase 31 214 2 0 0 2 3 hsa-miR-4498 -0.03 -0.05 N/A

INTS6 ENST00000311234.4 integrator complex subunit 6 433 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.08 N/A

MRGBP ENST00000370487.3 MRG/MORF4L binding protein 886 1 0 0 1 3 hsa-miR-5001-5p -0.03 -0.12 N/A

TBRG4 ENST00000258770.3 transforming growth factor beta regulator 4 129 1 1 0 0 2 hsa-miR-5001-5p -0.03 -0.25 N/A

ACP1 ENST00000272067.6 acid phosphatase 1, soluble 499 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.14 N/A

TPRA1 ENST00000296210.7 transmembrane protein, adipocyte asscociated 1 44 1 0 1 0 1 hsa-miR-4498 -0.03 -0.18 N/A

ADRBK2 ENST00000324198.6 adrenergic, beta, receptor kinase 2 215 1 0 1 0 1 hsa-miR-4498 -0.03 -0.16 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SYT13 ENST00000020926.3 synaptotagmin XIII 5 1 0 1 0 1 hsa-miR-4498 -0.03 -0.03 N/A

SREBF2 ENST00000361204.4 sterol regulatory element binding transcription factor 2 1518 1 0 1 0 1 hsa-miR-5001-5p -0.03 -0.03 N/A

TAOK1 ENST00000261716.3 TAO kinase 1 164 1 0 0 1 0 hsa-miR-4498 -0.03 -0.03 N/A

IL18BP ENST00000497194.2 interleukin 18 binding protein 41 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.23 N/A

ZNF446 ENST00000335841.4 zinc finger protein 446 44 2 1 0 1 0 hsa-miR-5001-5p -0.03 -0.34 N/A

MLPH ENST00000264605.3 melanophilin 85 1 0 1 0 1 hsa-miR-4498 -0.03 -0.21 N/A

PRKAB2 ENST00000254101.3 protein kinase, AMP-activated, beta 2 non-catalytic subunit 363 1 0 0 1 1 hsa-miR-5001-5p -0.03 -0.03 N/A

TBL1X ENST00000407597.2 transducin (beta)-like 1X-linked 125 1 0 1 0 1 hsa-miR-5001-5p -0.03 -0.03 N/A

MTMR9 ENST00000221086.3 myotubularin related protein 9 400 1 0 0 1 0 hsa-miR-5001-5p -0.03 -0.03 N/A

ITIH4 ENST00000266041.4 inter-alpha-trypsin inhibitor heavy chain family, member 4 42 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.23 N/A

RBFOX2 ENST00000449924.2 RNA binding protein, fox-1 homolog (C. elegans) 2 262 1 0 1 0 1 hsa-miR-4498 -0.03 -0.12 N/A

DOCK11 ENST00000276204.6 dedicator of cytokinesis 11 40 1 1 0 0 0 hsa-miR-5001-5p -0.03 -0.21 N/A

ATOH8 ENST00000306279.3 atonal homolog 8 (Drosophila) 21 3* 1 1 0 1 hsa-miR-5001-5p -0.03 -0.59 N/A

SUPT3H ENST00000371460.1 suppressor of Ty 3 homolog (S. cerevisiae) 175 1 0 1 0 0 hsa-miR-5001-5p -0.03 -0.27 N/A

STAG1 ENST00000383202.2 stromal antigen 1 94 1 0 1 0 0 hsa-miR-4498 -0.03 -0.04 N/A

DENND3 ENST00000519811.1 DENN/MADD domain containing 3 926 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.03 N/A

TIFA ENST00000361717.3 TRAF-interacting protein with forkhead-associated domain 400 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.18 N/A methylmalonic aciduria (cobalamin deficiency) cblD type, MMADHC ENST00000303319.5 250 1 0 1 0 0 hsa-miR-4498 -0.02 -0.18 N/A with homocystinuria NOP9 ENST00000396802.3 NOP9 nucleolar protein 353 1 0 0 1 3 hsa-miR-5001-5p -0.02 -0.04 N/A

SRSF10 ENST00000343255.5 serine/arginine-rich splicing factor 10 1920 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.21 N/A

TRAF6 ENST00000526995.1 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 91 1 0 1 0 2 hsa-miR-4498 -0.02 -0.38 N/A

PPIE ENST00000324379.5 peptidylprolyl isomerase E (cyclophilin E) 376 1 1 0 0 2 hsa-miR-5001-5p -0.02 -0.5 N/A

CLYBL ENST00000376355.3 citrate lyase beta like 108 2 0 2 0 3 hsa-miR-4498 -0.02 -0.3 N/A

APH1B ENST00000261879.5 APH1B gamma secretase subunit 223 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.11 N/A

MTL5 ENST00000255087.5 metallothionein-like 5, testis-specific (tesmin) 30 1 0 1 0 1 hsa-miR-4498 -0.02 -0.17 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score IL18R1 ENST00000409599.1 interleukin 18 receptor 1 40 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A

HOXD12 ENST00000404162.2 homeobox D12 6 1 0 1 0 0 hsa-miR-4498 -0.02 -0.19 N/A

EPC1 ENST00000319778.6 enhancer of polycomb homolog 1 (Drosophila) 102 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.15 N/A

ARID1B ENST00000346085.5 AT rich interactive domain 1B (SWI1-like) 220 1 0 1 0 0 hsa-miR-4498 -0.02 -0.16 N/A

CMTM7 ENST00000334983.5 CKLF-like MARVEL transmembrane domain containing 7 69 1 0 1 0 1 hsa-miR-4498 -0.02 -0.36 N/A

CYTH2 ENST00000427476.1 cytohesin 2 383 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.16 N/A

ERVMER34-1 ENST00000443173.1 endogenous retrovirus group MER34, member 1 28 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.23 N/A

NAA35 ENST00000361671.5 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 69 2 0 0 2 3 hsa-miR-5001-5p -0.02 -0.07 N/A

EFHC1 ENST00000371068.5 EF-hand domain (C-terminal) containing 1 61 1 0 1 0 0 hsa-miR-4498 -0.02 -0.13 N/A

PTAR1 ENST00000377200.5 protein prenyltransferase alpha subunit repeat containing 1 161 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.03 N/A

FAM107B ENST00000378470.1 family with sequence similarity 107, member B 403 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.15 N/A

SMG6 ENST00000544865.1 SMG6 nonsense mediated mRNA decay factor 832 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.02 N/A

GFER ENST00000569451.1 growth factor, augmenter of liver regeneration 882 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.22 N/A DCN1, defective in cullin neddylation 1, domain containing DCUN1D1 ENST00000292782.4 267 1 0 1 0 1 hsa-miR-4498 -0.02 -0.12 N/A 1 AKT1 ENST00000554581.1 v-akt murine thymoma viral oncogene homolog 1 214 2 0 2 0 6 hsa-miR-5001-5p -0.02 -0.15 N/A NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, NDUFA10 ENST00000252711.2 2249 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.12 N/A 42kDa INO80 ENST00000361937.3 INO80 complex subunit 279 2 0 2 0 1 hsa-miR-4498 -0.02 -0.15 N/A

MFHAS1 ENST00000276282.6 malignant fibrous histiocytoma amplified sequence 1 130 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.03 N/A

SPINK4 ENST00000379721.3 serine peptidase inhibitor, Kazal type 4 522 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.88 N/A

HERPUD2 ENST00000396081.1 HERPUD family member 2 30 2 0 1 1 0 hsa-miR-4498 -0.02 -0.24 N/A

DHX37 ENST00000544745.1 DEAH (Asp-Glu-Ala-His) box polypeptide 37 63 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.03 N/A Paf1, RNA polymerase II associated factor, homolog (S. PAF1 ENST00000221265.3 490 2 0 1 1 0 hsa-miR-4498 -0.02 -0.48 N/A cerevisiae) WDR12 ENST00000261015.4 WD repeat domain 12 444 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.27 N/A

APOA1 ENST00000375320.1 apolipoprotein A-I 1201 3 1 1 1 1 hsa-miR-5001-5p -0.02 -0.73 N/A

PCCB ENST00000469217.1 propionyl CoA carboxylase, beta polypeptide 379 1 1 0 0 0 hsa-miR-4498 -0.02 -0.23 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ALKBH7 ENST00000599849.1 alkB, alkylation repair homolog 7 (E. coli) 3818 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.47 N/A

SMIM1 ENST00000444870.2 small integral membrane protein 1 309 2 0 1 1 3 hsa-miR-5001-5p -0.02 -0.51 N/A

TECPR2 ENST00000359520.7 tectonin beta-propeller repeat containing 2 109 2 1 0 1 1 hsa-miR-4492 -0.02 -0.04 N/A

IRAK1 ENST00000369980.3 interleukin-1 receptor-associated kinase 1 54 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A

LYRM4 ENST00000330636.4 LYR motif containing 4 796 2 2 0 0 2 hsa-miR-5001-5p -0.02 -0.52 N/A

WBP1L ENST00000369889.4 WW domain binding protein 1-like 5 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.02 N/A

AFF1 ENST00000395146.4 AF4/FMR2 family, member 1 28 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.06 N/A

PLAGL2 ENST00000246229.4 pleiomorphic adenoma gene-like 2 254 1 1 0 0 1 hsa-miR-5001-5p -0.02 -0.2 N/A

FBXO9 ENST00000244426.6 F-box protein 9 904 2 0 2 0 0 hsa-miR-4498 -0.02 -0.28 N/A

ZNF678 ENST00000343776.5 zinc finger protein 678 89 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A

TK2 ENST00000299697.7 thymidine kinase 2, mitochondrial 439 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.02 N/A polycystic kidney and hepatic disease 1 (autosomal PKHD1 ENST00000371117.3 5 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A recessive) DNAJB4 ENST00000370763.5 DnaJ (Hsp40) homolog, subfamily B, member 4 633 1 0 1 0 0 hsa-miR-4498 -0.02 -0.25 N/A

KIAA0101 ENST00000558008.1 KIAA0101 6821 1 1 0 0 0 hsa-miR-4498 -0.02 -0.35 N/A

POLR1B ENST00000409894.3 polymerase (RNA) I polypeptide B, 128kDa 996 1 1 0 0 0 hsa-miR-4498 -0.02 -0.31 N/A translocase of inner mitochondrial membrane 8 homolog A TIMM8A ENST00000372902.3 147 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.17 N/A (yeast) ZNF33B ENST00000359467.3 zinc finger protein 33B 30 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.13 N/A

GTF2F1 ENST00000394456.5 general transcription factor IIF, polypeptide 1, 74kDa 1014 2 1 1 0 1 hsa-miR-5001-5p -0.02 -0.26 N/A

NCAPH2 ENST00000420993.2 non-SMC condensin II complex, subunit H2 758 2 1 1 0 2 hsa-miR-5001-5p -0.02 -0.53 N/A

ZSWIM5 ENST00000359600.5 zinc finger, SWIM-type containing 5 31 1 0 0 1 0 hsa-miR-762 -0.02 -0.13 N/A

ACOT13 ENST00000537591.1 acyl-CoA thioesterase 13 1489 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.26 N/A

ARSB ENST00000264914.4 arylsulfatase B 86 1 1 0 0 1 hsa-miR-4498 -0.02 -0.21 N/A

RCL1 ENST00000381750.4 RNA terminal phosphate cyclase-like 1 203 2 0 2 0 1 hsa-miR-5001-5p -0.02 -0.24 N/A

SETX ENST00000224140.5 senataxin 270 1 0 1 0 2 hsa-miR-5001-5p -0.02 -0.3 N/A

MTG1 ENST00000317502.6 mitochondrial ribosome-associated GTPase 1 1071 3 1 1 1 0 hsa-miR-5001-5p -0.02 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RP11-108K14.8 ENST00000468317.2 Mitochondrial GTPase 1 1071 3 1 1 1 0 hsa-miR-5001-5p -0.02 -0.27 N/A

MPPED1 ENST00000417669.2 metallophosphoesterase domain containing 1 51 1 0 1 0 1 hsa-miR-4498 -0.02 -0.06 N/A

DGKZ ENST00000343674.6 diacylglycerol kinase, zeta 65 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ZNF534 ENST00000301085.4 zinc finger protein 534 5 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

BRD4 ENST00000263377.2 bromodomain containing 4 849 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

COL18A1 ENST00000400337.2 collagen, type XVIII, alpha 1 1051 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

CELSR1 ENST00000262738.3 cadherin, EGF LAG seven-pass G-type receptor 1 1359 1 0 1 0 2 hsa-miR-4492 -0.02 -0.02 N/A

TCN2 ENST00000215838.3 transcobalamin II 132 2 0 0 2 2 hsa-miR-4498 -0.02 -0.21 N/A UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, B4GALT4 ENST00000467604.1 196 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A polypeptide 4 STXBP5L ENST00000273666.6 syntaxin binding protein 5-like 19 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ABCB9 ENST00000280560.8 ATP-binding cassette, sub-family B (MDR/TAP), member 9 13 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

NPAS4 ENST00000311034.2 neuronal PAS domain protein 4 5 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

NRK ENST00000243300.9 Nik related kinase 5 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ARHGAP26 ENST00000378004.3 Rho GTPase activating protein 26 131 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A

FER ENST00000281092.4 fer (fps/fes related) tyrosine kinase 665 1 0 1 0 4 hsa-miR-4492 -0.02 -0.02 N/A

LEPROT ENST00000371065.4 leptin receptor overlapping transcript 397 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

WWP2 ENST00000359154.2 WW domain containing E3 ubiquitin protein ligase 2 405 1 0 1 0 3 hsa-miR-4492 -0.02 -0.02 N/A

FRMD8 ENST00000317568.5 FERM domain containing 8 1094 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

A4GALT ENST00000401850.1 alpha 1,4-galactosyltransferase 21 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A

PRR14L ENST00000434485.1 proline rich 14-like 39 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A

PDCD11 ENST00000369797.3 programmed cell death 11 1551 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

MYH14 ENST00000601313.1 myosin, heavy chain 14, non-muscle 54 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

INHBB ENST00000295228.3 inhibin, beta B 75 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ANK1 ENST00000289734.7 ankyrin 1, erythrocytic 5 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

EXOC6B ENST00000272427.6 exocyst complex component 6B 106 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GRP1 (general receptor for phosphoinositides 1)-associated GRASP ENST00000552049.1 51 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A scaffold protein microtubule associated monooxygenase, calponin and LIM MICAL2 ENST00000379612.3 1742 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A domain containing 2 GRIA1 ENST00000285900.5 glutamate receptor, ionotropic, AMPA 1 5 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A

BICD2 ENST00000356884.6 bicaudal D homolog 2 (Drosophila) 38 1 0 1 0 2 hsa-miR-4492 -0.02 -0.02 N/A

MAPK8IP2 ENST00000399908.2 mitogen-activated protein kinase 8 interacting protein 2 88 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A ADAM metallopeptidase with thrombospondin type 1 motif, ADAMTS10 ENST00000595838.1 7 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A 10 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac PREX1 ENST00000396220.1 14 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A exchange factor 1 PRDM15 ENST00000422911.1 PR domain containing 15 328 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ZC3H6 ENST00000343936.4 zinc finger CCCH-type containing 6 10 2 0 0 2 0 hsa-miR-4492 -0.02 -0.02 N/A potassium voltage-gated channel, KQT-like subfamily, KCNQ4 ENST00000347132.5 46 1 0 1 0 2 hsa-miR-4492 -0.02 -0.02 N/A member 4 SPTBN4 ENST00000352632.3 spectrin, beta, non-erythrocytic 4 7 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

PARD3B ENST00000406610.2 par-3 family cell polarity regulator beta 38 1 0 1 0 2 hsa-miR-4492 -0.02 -0.02 N/A transient receptor potential cation channel, subfamily M, TRPM5 ENST00000155858.6 5 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A member 5 EPHB3 ENST00000330394.2 EPH receptor B3 16 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

ORAI1 ENST00000330079.7 ORAI calcium release-activated calcium modulator 1 652 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.23 N/A

PSMG1 ENST00000331573.3 proteasome (prosome, macropain) assembly chaperone 1 31 1 0 1 0 0 hsa-miR-4498 -0.02 -0.12 N/A growth arrest and DNA-damage-inducible, gamma GADD45GIP1 ENST00000316939.1 981 1 0 1 0 0 hsa-miR-4498 -0.02 -0.22 N/A interacting protein 1 ZNF516 ENST00000443185.2 zinc finger protein 516 311 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.06 N/A

MAP4K4 ENST00000413150.2 mitogen-activated protein kinase kinase kinase kinase 4 1551 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.07 N/A

ZBTB42 ENST00000342537.7 zinc finger and BTB domain containing 42 182 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.02 N/A

C12orf4 ENST00000261250.3 chromosome 12 open reading frame 4 37 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.08 N/A

FAM69B ENST00000371692.4 family with sequence similarity 69, member B 1836 3 1 1 1 1 hsa-miR-5001-5p -0.02 -0.93 N/A

NFAT5 ENST00000354436.2 nuclear factor of activated T-cells 5, tonicity-responsive 128 2 0 1 1 0 hsa-miR-4498 -0.02 -0.05 N/A

HMX1 ENST00000400677.3 H6 family homeobox 1 171 2 0 2 0 3 hsa-miR-4498 -0.02 -0.27 N/A

TFDP2 ENST00000499676.2 transcription factor Dp-2 (E2F dimerization partner 2) 128 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.19 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score UPF1 ENST00000262803.5 UPF1 regulator of nonsense transcripts homolog (yeast) 513 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A

DUT ENST00000559540.1 deoxyuridine triphosphatase 1860 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.17 N/A

GOSR1 ENST00000225724.5 golgi SNAP receptor complex member 1 668 1 0 1 0 2 hsa-miR-4498 -0.02 -0.21 N/A

MED17 ENST00000251871.3 mediator complex subunit 17 197 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.15 N/A

SPICE1 ENST00000295872.4 spindle and centriole associated protein 1 160 1 0 1 0 0 hsa-miR-4498 -0.02 -0.2 N/A BTB and CNC homology 1, basic leucine zipper BACH2 ENST00000257749.4 74 1 0 1 0 3 hsa-miR-4492 -0.02 -0.02 N/A transcription factor 2 DIS3 ENST00000377767.4 DIS3 mitotic control homolog (S. cerevisiae) 140 2 0 1 1 0 hsa-miR-5001-5p -0.02 -0.21 N/A ectopic P-granules autophagy protein 5 homolog (C. EPG5 ENST00000282041.5 269 2 0 2 0 0 hsa-miR-4492 -0.02 -0.04 N/A elegans) solute carrier family 8 (sodium/lithium/calcium exchanger), SLC8B1 ENST00000552014.1 34 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.13 N/A member B1 DDX3X ENST00000399959.2 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 965 1 0 1 0 1 hsa-miR-4498 -0.02 -0.07 N/A

ZMYND11 ENST00000381591.1 zinc finger, MYND-type containing 11 43 1 0 1 0 0 hsa-miR-4498 -0.02 -0.13 N/A

TMC8 ENST00000318430.5 transmembrane channel-like 8 13 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.05 N/A

FBXL20 ENST00000394294.3 F-box and leucine-rich repeat protein 20 455 1 1 0 0 1 hsa-miR-5001-5p -0.02 -0.04 N/A

GIN1 ENST00000399004.2 gypsy retrotransposon integrase 1 189 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.52 N/A

PHKB ENST00000455779.1 phosphorylase kinase, beta 973 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.28 N/A

CYLD ENST00000540145.1 cylindromatosis (turban tumor syndrome) 696 1 0 1 0 0 hsa-miR-4498 -0.02 -0.07 N/A

THRB ENST00000396671.2 thyroid hormone receptor, beta 55 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.03 N/A

MXD1 ENST00000264444.2 MAX dimerization protein 1 183 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.12 N/A

NEK6 ENST00000373603.1 NIMA-related kinase 6 3449 1 0 1 0 2 hsa-miR-4498 -0.02 -0.18 N/A

STOX2 ENST00000308497.4 storkhead box 2 379 1 0 0 1 0 hsa-miR-4498 -0.02 -0.02 N/A

TTC3 ENST00000399017.2 tetratricopeptide repeat domain 3 62 1 0 1 0 0 hsa-miR-4492 -0.02 -0.02 N/A SWI/SNF related, matrix associated, actin dependent SMARCE1 ENST00000377808.4 252 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.09 N/A regulator of chromatin, subfamily e, member 1 A1CF ENST00000374001.2 APOBEC1 complementation factor 80 1 0 0 1 2 hsa-miR-4498 -0.02 -0.08 N/A

SDHAF1 ENST00000378887.2 succinate dehydrogenase complex assembly factor 1 2317 2 0 2 0 0 hsa-miR-4498 -0.02 -0.41 N/A

FMNL3 ENST00000335154.5 formin-like 3 132 1 0 1 0 2 hsa-miR-4498 -0.02 -0.06 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TMEM255B ENST00000375353.3 transmembrane protein 255B 7 1 0 1 0 1 hsa-miR-4498 -0.02 -0.16 N/A

AHCYL2 ENST00000325006.3 adenosylhomocysteinase-like 2 51 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.08 N/A

UBR2 ENST00000372883.3 ubiquitin protein ligase E3 component n-recognin 2 728 1 0 1 0 0 hsa-miR-4498 -0.02 -0.04 N/A

CELF2 ENST00000379261.4 CUGBP, Elav-like family member 2 45 1 1 0 0 2 hsa-miR-5001-5p -0.02 -0.09 N/A

MYPN ENST00000358913.5 myopalladin 73 2 1 0 1 0 hsa-miR-5001-5p -0.02 -0.07 N/A

HMHA1 ENST00000313093.2 histocompatibility (minor) HA-1 35 2 0 1 1 1 hsa-miR-5001-5p -0.02 -0.14 N/A

ABCF3 ENST00000429586.2 ATP-binding cassette, sub-family F (GCN20), member 3 710 2 0 1 1 3 hsa-miR-5001-5p -0.02 -0.53 N/A

URGCP ENST00000223341.7 upregulator of cell proliferation 180 2 0 1 1 2 hsa-miR-5001-5p -0.02 -0.23 N/A

GDF7 ENST00000272224.3 growth differentiation factor 7 27 1 0 1 0 2 hsa-miR-5001-5p -0.02 -0.07 N/A

C9orf85 ENST00000486911.2 chromosome 9 open reading frame 85 57 1 0 1 0 0 hsa-miR-5001-5p -0.02 -0.21 N/A

WBP4 ENST00000379487.3 WW domain binding protein 4 153 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.33 N/A

MAN2A2 ENST00000360468.3 mannosidase, alpha, class 2A, member 2 340 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A heat shock 70kDa protein 5 (glucose-regulated protein, HSPA5 ENST00000324460.6 2715 1 0 1 0 0 hsa-miR-4498 -0.02 -0.08 N/A 78kDa) TSPAN31 ENST00000547992.1 tetraspanin 31 72 2 0 0 2 0 hsa-miR-5001-5p -0.02 -0.26 N/A

ADAM22 ENST00000398204.4 ADAM metallopeptidase domain 22 115 2 0 1 1 0 hsa-miR-5001-5p -0.02 -0.03 N/A

SF3B3 ENST00000302516.5 splicing factor 3b, subunit 3, 130kDa 2541 3 2 0 1 0 hsa-miR-5001-5p -0.02 -0.49 N/A

RFT1 ENST00000296292.3 RFT1 homolog (S. cerevisiae) 392 2 0 1 1 0 hsa-miR-5001-5p -0.02 -0.33 N/A sema domain, transmembrane domain (TM), and SEMA6A ENST00000343348.6 106 1 0 1 0 0 hsa-miR-4498 -0.02 -0.21 N/A cytoplasmic domain, (semaphorin) 6A CLMN ENST00000298912.4 calmin (calponin-like, transmembrane) 53 3* 0 1 1 3 hsa-miR-5001-5p -0.02 -0.1 N/A ATP synthase, H+ transporting, mitochondrial Fo complex, ATP5F1 ENST00000369722.3 347 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.15 N/A subunit B1 ZNF382 ENST00000292928.2 zinc finger protein 382 54 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.19 N/A solute carrier family 35 (GDP-fucose transporter), member SLC35C2 ENST00000372227.1 910 2 2 0 0 4 hsa-miR-5001-5p -0.02 -0.59 N/A C2 LRRC47 ENST00000378251.1 leucine rich repeat containing 47 168 2 0 1 1 0 hsa-miR-5001-5p -0.02 -0.13 N/A TIA1 cytotoxic granule-associated RNA binding protein-like TIAL1 ENST00000369093.2 1342 1 1 0 0 0 hsa-miR-5001-5p -0.02 -0.23 N/A 1 RPS6KA3 ENST00000379565.3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 769 1 0 0 1 0 hsa-miR-4498 -0.02 -0.1 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NOL10 ENST00000345985.3 nucleolar protein 10 106 1 0 1 0 2 hsa-miR-5001-5p -0.02 -0.05 N/A

MRPL30 ENST00000338148.3 mitochondrial ribosomal protein L30 246 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.25 N/A

TRIM45 ENST00000256649.4 tripartite motif containing 45 99 1 0 0 1 2 hsa-miR-4498 -0.02 -0.1 N/A

ZNF207 ENST00000394670.4 zinc finger protein 207 839 1 0 1 0 1 hsa-miR-4492 -0.02 -0.02 N/A

C2orf15 ENST00000512183.2 chromosome 2 open reading frame 15 246 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.25 N/A

HOXA3 ENST00000396352.4 homeobox A3 57 1 0 1 0 1 hsa-miR-5001-5p -0.02 -0.19 N/A

SERBP1 ENST00000370994.4 SERPINE1 mRNA binding protein 1 926 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A

ZSCAN16 ENST00000340487.4 zinc finger and SCAN domain containing 16 66 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.16 N/A

CABLES2 ENST00000279101.5 Cdk5 and Abl enzyme substrate 2 450 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.02 N/A

INPP4A ENST00000409016.4 inositol polyphosphate-4-phosphatase, type I, 107kDa 387 3 1 2 0 0 hsa-miR-4498 -0.02 -0.4 N/A

CREBBP ENST00000262367.5 CREB binding protein 532 1 0 1 0 0 hsa-miR-4498 -0.02 -0.12 N/A

SLC35F1 ENST00000360388.4 solute carrier family 35, member F1 56 1 0 0 1 1 hsa-miR-5001-5p -0.02 -0.13 N/A

SMURF2 ENST00000262435.9 SMAD specific E3 ubiquitin protein ligase 2 978 1 0 0 1 0 hsa-miR-4498 -0.02 -0.12 N/A

SNRPD1 ENST00000300413.5 small nuclear ribonucleoprotein D1 polypeptide 16kDa 1967 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.11 N/A ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with CLN8 ENST00000331222.4 122 1 0 1 0 2 hsa-miR-4498 -0.02 -0.17 N/A mental retardation) guanine nucleotide binding protein (G protein), beta GNB1L ENST00000329517.6 210 6 1 4 1 5 hsa-miR-5001-5p -0.02 -0.84 N/A polypeptide 1-like BDNF ENST00000439476.2 brain-derived neurotrophic factor 2696 1 0 0 1 0 hsa-miR-5001-5p -0.02 -0.15 N/A DCN1, defective in cullin neddylation 1, domain containing DCUN1D3 ENST00000324344.4 53 1 0 0 1 1 hsa-miR-4498 -0.01 -0.03 N/A 3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, SERPINA4 ENST00000555095.1 203 1 0 1 0 1 hsa-miR-4498 -0.01 -0.21 N/A antitrypsin), member 4 VLDLR ENST00000382100.3 very low density lipoprotein receptor 977 1 0 1 0 0 hsa-miR-4498 -0.01 -0.12 N/A

TMEM175 ENST00000264771.4 transmembrane protein 175 91 2 0 1 1 0 hsa-miR-5001-5p -0.01 -0.33 N/A

TM2D2 ENST00000456845.2 TM2 domain containing 2 1085 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.55 N/A

TCF21 ENST00000367882.4 transcription factor 21 552 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.14 N/A

SUSD1 ENST00000374263.3 sushi domain containing 1 68 2 0 2 0 0 hsa-miR-4498 -0.01 -0.11 N/A

ZXDA ENST00000358697.4 zinc finger, X-linked, duplicated A 25 1 0 1 0 1 hsa-miR-4498 -0.01 -0.03 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TLN2 ENST00000561311.1 talin 2 371 2 1 1 0 1 hsa-miR-4498 -0.01 -0.11 N/A

HELZ ENST00000358691.5 helicase with zinc finger 571 1 0 1 0 0 hsa-miR-4492 -0.01 -0.02 N/A

SRSF7 ENST00000313117.6 serine/arginine-rich splicing factor 7 16077 1 1 0 0 0 hsa-miR-4498 -0.01 -0.52 N/A

AGTPBP1 ENST00000376083.3 ATP/GTP binding protein 1 187 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.16 N/A

PKP4 ENST00000389757.3 plakophilin 4 373 2 1 0 1 2 hsa-miR-5001-5p -0.01 -0.52 N/A

DNAAF2 ENST00000298292.8 dynein, axonemal, assembly factor 2 78 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.17 N/A

HDAC4 ENST00000345617.3 histone deacetylase 4 48 1 0 1 0 1 hsa-miR-4492 -0.01 -0.02 N/A

TOR1AIP2 ENST00000367612.3 torsin A interacting protein 2 569 1 0 1 0 1 hsa-miR-4498 -0.01 -0.16 N/A

UBA6 ENST00000322244.5 ubiquitin-like modifier activating enzyme 6 169 2 0 2 0 1 hsa-miR-4498 -0.01 -0.14 N/A

DDI2 ENST00000480945.1 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 357 1 0 0 1 2 hsa-miR-4498 -0.01 -0.17 N/A

MICA ENST00000449934.2 MHC class I polypeptide-related sequence A 742 1 1 0 0 1 hsa-miR-5001-5p -0.01 -0.24 N/A

GSR ENST00000221130.5 glutathione reductase 858 2 1 1 0 0 hsa-miR-4498 -0.01 -0.31 N/A

TMX1 ENST00000457354.2 thioredoxin-related transmembrane protein 1 3176 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.11 N/A

VWA1 ENST00000338660.5 von Willebrand factor A domain containing 1 145 1 0 0 1 2 hsa-miR-5001-5p -0.01 -0.2 N/A

FAT2 ENST00000261800.5 FAT atypical cadherin 2 5 1 0 0 1 0 hsa-miR-4498 -0.01 -0.01 N/A

LRP4 ENST00000378623.1 low density lipoprotein receptor-related protein 4 152 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.01 N/A

MXRA7 ENST00000355797.3 matrix-remodelling associated 7 421 2 0 1 1 0 hsa-miR-5001-5p -0.01 -0.22 N/A

RPS6KA6 ENST00000262752.2 ribosomal protein S6 kinase, 90kDa, polypeptide 6 156 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.09 N/A

ARL8B ENST00000419534.2 ADP-ribosylation factor-like 8B 664 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.3 N/A

AGBL3 ENST00000359383.3 ATP/GTP binding protein-like 3 148 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.23 N/A

ZNF71 ENST00000328070.6 zinc finger protein 71 152 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.12 N/A

NBPF14 ENST00000369219.1 neuroblastoma breakpoint family, member 14 10 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.03 N/A

STXBP4 ENST00000376352.2 syntaxin binding protein 4 62 2 0 0 2 0 hsa-miR-4492 -0.01 -0.02 N/A

ACOX1 ENST00000293217.5 acyl-CoA oxidase 1, palmitoyl 287 1 0 1 0 0 hsa-miR-4498 -0.01 -0.15 N/A

HM13 ENST00000335574.5 histocompatibility (minor) 13 4848 4 1 3 0 1 hsa-miR-4498 -0.01 -0.7 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ASS1 ENST00000352480.5 argininosuccinate synthase 1 829 1 0 0 1 1 hsa-miR-4498 -0.01 -0.17 N/A

MSANTD2 ENST00000239614.4 Myb/SANT-like DNA-binding domain containing 2 50 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.19 N/A

PCDHB16 ENST00000361016.2 protocadherin beta 16 36 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.08 N/A

TMEM44 ENST00000381975.3 transmembrane protein 44 45 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.1 N/A

HLX ENST00000366903.6 H2.0-like homeobox 28 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.17 N/A

GRHPR ENST00000318158.6 glyoxylate reductase/hydroxypyruvate reductase 572 2 0 2 0 2 hsa-miR-4498 -0.01 -0.5 N/A

SETD9 ENST00000285947.2 SET domain containing 9 45 1 1 0 0 1 hsa-miR-5001-5p -0.01 -0.21 N/A

CASD1 ENST00000297273.4 CAS1 domain containing 1 270 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.11 N/A

HEBP2 ENST00000607197.1 heme binding protein 2 252 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.07 N/A

FEM1B ENST00000306917.4 fem-1 homolog b (C. elegans) 656 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.03 N/A

CISD1 ENST00000333926.5 CDGSH iron sulfur domain 1 367 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.08 N/A

POLR1C ENST00000372389.3 polymerase (RNA) I polypeptide C, 30kDa 23 1 0 1 0 0 hsa-miR-4498 -0.01 -0.21 N/A solute carrier family 5 (sodium/monocarboxylate SLC5A12 ENST00000396005.3 8 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.02 N/A cotransporter), member 12 NFIB ENST00000397575.3 nuclear factor I/B 1149 1 0 0 1 2 hsa-miR-4498 -0.01 -0.13 N/A

BRD1 ENST00000457780.2 bromodomain containing 1 124 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.01 N/A

H2AFJ ENST00000544848.1 H2A histone family, member J 482 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.15 N/A

MTPAP ENST00000263063.4 mitochondrial poly(A) polymerase 137 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.08 N/A

MON2 ENST00000546600.1 MON2 homolog (S. cerevisiae) 784 1 0 1 0 0 hsa-miR-4498 -0.01 -0.24 N/A

RAD51D ENST00000345365.6 RAD51 paralog D 73 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.13 N/A

PPAPDC1A ENST00000398248.1 phosphatidic acid phosphatase type 2 domain containing 1A 29 1 0 1 0 2 hsa-miR-4498 -0.01 -0.27 N/A

ZCCHC11 ENST00000257177.4 zinc finger, CCHC domain containing 11 97 1 1 0 0 1 hsa-miR-5001-5p -0.01 -0.28 N/A sema domain, immunoglobulin domain (Ig), short basic SEMA3A ENST00000265362.4 162 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.07 N/A domain, secreted, (semaphorin) 3A POC1A ENST00000296484.2 POC1 centriolar protein A 1025 3 1 2 0 1 hsa-miR-5001-5p -0.01 -0.67 N/A

TRIM72 ENST00000322122.3 tripartite motif containing 72 8 3 1 1 1 0 hsa-miR-762 -0.01 -0.21 N/A

DLK1 ENST00000341267.4 delta-like 1 homolog (Drosophila) 1865 5 0 5 0 3 hsa-miR-4498 -0.01 -0.75 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score GRID1 ENST00000327946.7 glutamate receptor, ionotropic, delta 1 45 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.12 N/A

FAF1 ENST00000396153.2 Fas (TNFRSF6) associated factor 1 428 1 0 1 0 3 hsa-miR-5001-5p -0.01 -0.17 N/A

ANXA6 ENST00000354546.5 annexin A6 10462 2 0 2 0 0 hsa-miR-4498 -0.01 -0.18 N/A

MFSD6 ENST00000392328.1 major facilitator superfamily domain containing 6 47 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.07 N/A

SMIM12 ENST00000521580.2 small integral membrane protein 12 1091 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.46 N/A

DBNL ENST00000494774.1 drebrin-like 1802 5 0 3 2 7 hsa-miR-4498 -0.01 -0.48 N/A NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, NDUFA6 ENST00000602404.1 1691 1 0 1 0 0 hsa-miR-4498 -0.01 -0.42 N/A 14kDa TENM4 ENST00000278550.7 teneurin transmembrane protein 4 34 3 0 1 2 3 hsa-miR-4498 -0.01 -0.08 N/A

OIP5 ENST00000220514.3 Opa interacting protein 5 178 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.67 N/A

C9orf114 ENST00000361256.5 chromosome 9 open reading frame 114 488 4 0 3 1 2 hsa-miR-5001-5p -0.01 -0.37 N/A

MMAB ENST00000545712.2 methylmalonic aciduria (cobalamin deficiency) cblB type 2107 2 0 1 1 5 hsa-miR-5001-5p -0.01 -0.42 N/A solute carrier family 25 (mitochondrial carrier; oxoglutarate SLC25A11 ENST00000225665.7 1867 2 0 2 0 0 hsa-miR-4498 -0.01 -0.32 N/A carrier), member 11 ANKRD45 ENST00000333279.2 ankyrin repeat domain 45 10 2 2 0 0 1 hsa-miR-5001-5p -0.01 -0.47 N/A

MED28 ENST00000237380.7 mediator complex subunit 28 1483 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.46 N/A

PTCHD1 ENST00000379361.4 patched domain containing 1 59 2 1 1 0 0 hsa-miR-5001-5p -0.01 -0.09 N/A

PKNOX1 ENST00000291547.5 PBX/knotted 1 homeobox 1 297 2 0 2 0 2 hsa-miR-4498 -0.01 -0.35 N/A

GSPT1 ENST00000434724.2 G1 to S phase transition 1 1119 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.09 N/A

ATXN3 ENST00000545170.1 ataxin 3 115 1 0 1 0 1 hsa-miR-4498 -0.01 -0.15 N/A

ZNF324 ENST00000536459.2 zinc finger protein 324 82 2 0 0 2 1 hsa-miR-5001-5p -0.01 -0.09 N/A

AK1 ENST00000373176.1 adenylate kinase 1 1343 2 0 1 1 0 hsa-miR-5001-5p -0.01 -0.38 N/A

TNRC6A ENST00000395799.3 trinucleotide repeat containing 6A 267 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.01 N/A

SUMO2 ENST00000420826.2 small ubiquitin-like modifier 2 75 1 0 1 0 0 hsa-miR-4498 -0.01 -0.24 N/A

ABCG1 ENST00000398457.2 ATP-binding cassette, sub-family G (WHITE), member 1 64 1 1 0 0 2 hsa-miR-4498 -0.01 -0.23 N/A

ZNF354B ENST00000322434.3 zinc finger protein 354B 52 1 0 1 0 0 hsa-miR-4498 -0.01 -0.19 N/A KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein KDELR2 ENST00000258739.4 5077 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.09 N/A retention receptor 2 Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NT5DC1 ENST00000319550.4 5'-nucleotidase domain containing 1 127 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.12 N/A

FGFR1OP ENST00000366847.4 FGFR1 oncogene partner 552 3 2 1 0 1 hsa-miR-5001-5p -0.01 -0.14 N/A

HPX ENST00000265983.3 hemopexin 307 2 0 2 0 1 hsa-miR-4498 -0.01 -0.19 N/A

RUNDC1 ENST00000361677.1 RUN domain containing 1 927 1 0 0 1 0 hsa-miR-4498 -0.01 -0.17 N/A

IST1 ENST00000329908.8 increased sodium tolerance 1 homolog (yeast) 305 1 0 1 0 1 hsa-miR-4498 -0.01 -0.29 N/A

CCNB1IP1 ENST00000398160.2 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase 20 1 0 1 0 0 hsa-miR-4492 -0.01 -0.02 N/A

FAM92A1 ENST00000518322.1 family with sequence similarity 92, member A1 80 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.18 N/A

SOX5 ENST00000546136.1 SRY (sex determining region Y)-box 5 43 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.03 N/A

SF3A3 ENST00000373019.4 splicing factor 3a, subunit 3, 60kDa 59 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.02 N/A

ABHD5 ENST00000458276.2 abhydrolase domain containing 5 884 1 0 1 0 0 hsa-miR-4498 -0.01 -0.2 N/A

IPPK ENST00000287996.3 inositol 1,3,4,5,6-pentakisphosphate 2-kinase 211 2 1 1 0 0 hsa-miR-4498 -0.01 -0.16 N/A

CNOT6L ENST00000504123.1 CCR4-NOT transcription complex, subunit 6-like 23 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.05 N/A

KIAA1919 ENST00000368847.4 KIAA1919 73 1 0 1 0 0 hsa-miR-4498 -0.01 -0.16 N/A

C10orf55 ENST00000409178.1 chromosome 10 open reading frame 55 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

ZNF471 ENST00000591537.1 zinc finger protein 471 30 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

TNPO2 ENST00000425528.1 transportin 2 1620 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

NBPF20 ENST00000369202.1 neuroblastoma breakpoint family, member 20 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

PNMA6C ENST00000421798.3 paraneoplastic Ma antigen family member 6C 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

ITSN2 ENST00000361999.3 intersectin 2 63 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

ATXN7L3 ENST00000454077.2 ataxin 7-like 3 43 1 0 0 1 1 hsa-miR-4492 -0.01 -0.01 N/A

ATXN1L ENST00000427980.2 ataxin 1-like 12 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

RPS6KB1 ENST00000225577.4 ribosomal protein S6 kinase, 70kDa, polypeptide 1 16 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

RORB ENST00000376896.3 RAR-related orphan receptor B 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

FBLN2 ENST00000404922.3 fibulin 2 59 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

CHD2 ENST00000394196.4 chromodomain helicase DNA binding protein 2 1237 1 0 0 1 1 hsa-miR-4492 -0.01 -0.01 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score potassium voltage-gated channel, KQT-like subfamily, KCNQ3 ENST00000388996.4 5 1 0 0 1 1 hsa-miR-4492 -0.01 -0.01 N/A member 3 solute carrier family 5 (sodium/sugar cotransporter), member SLC5A10 ENST00000317977.6 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A 10 KBTBD6 ENST00000379485.1 kelch repeat and BTB (POZ) domain containing 6 51 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

PNMA6A ENST00000453825.2 paraneoplastic Ma antigen family member 6A 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

SLC1A7 ENST00000371494.4 solute carrier family 1 (glutamate transporter), member 7 11 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

FBXO40 ENST00000338040.4 F-box protein 40 5 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

PALM2-AKAP2 ENST00000374530.3 PALM2-AKAP2 readthrough 1287 1 0 0 1 2 hsa-miR-4492 -0.01 -0.01 N/A

ZNF771 ENST00000319296.5 zinc finger protein 771 87 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.18 N/A

AKAP2 ENST00000374525.1 A kinase (PRKA) anchor protein 2 1287 1 0 0 1 2 hsa-miR-4492 -0.01 -0.01 N/A

OXSR1 ENST00000311806.3 oxidative stress responsive 1 1790 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

DNASE1L2 ENST00000564065.1 deoxyribonuclease I-like 2 35 1 0 1 0 3 hsa-miR-5001-5p -0.01 -0.16 N/A

C14orf142 ENST00000306954.4 chromosome 14 open reading frame 142 66 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.32 N/A

SOS1 ENST00000426016.1 son of sevenless homolog 1 (Drosophila) 189 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.07 N/A

MYO1E ENST00000288235.4 myosin IE 198 1 0 1 0 1 hsa-miR-4498 -0.01 -0.24 N/A

MARC1 ENST00000366910.5 mitochondrial amidoxime reducing component 1 1613 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.46 N/A proteasome (prosome, macropain) 26S subunit, non-ATPase, PSMD9 ENST00000541212.1 1981 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.3 N/A 9 IMP4, U3 small nucleolar ribonucleoprotein, homolog IMP4 ENST00000409935.1 955 3 0 1 2 0 hsa-miR-4498 -0.01 -0.38 N/A (yeast) ABCG8 ENST00000272286.2 ATP-binding cassette, sub-family G (WHITE), member 8 197 1 0 0 1 1 hsa-miR-4498 -0.01 -0.23 N/A ADP-ribosylation factor guanine nucleotide-exchange factor ARFGEF1 ENST00000262215.3 70 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.29 N/A 1 (brefeldin A-inhibited) RABAC1 ENST00000601891.1 Rab acceptor 1 (prenylated) 2218 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.58 N/A

ATP7A ENST00000343533.5 ATPase, Cu++ transporting, alpha polypeptide 141 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

RRAGD ENST00000369415.4 Ras-related GTP binding D 644 3 1 1 1 0 hsa-miR-4498 -0.01 -0.28 N/A

IDE ENST00000265986.6 insulin-degrading enzyme 446 2 1 1 0 1 hsa-miR-5001-5p -0.01 -0.1 N/A

RAB11A ENST00000569896.1 RAB11A, member RAS oncogene family 5781 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.14 N/A

ARSA ENST00000356098.5 arylsulfatase A 103 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.14 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ALG10B ENST00000308742.4 ALG10B, alpha-1,2-glucosyltransferase 471 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

FAM105B ENST00000284274.4 family with sequence similarity 105, member B 247 1 0 1 0 2 hsa-miR-5001-5p -0.01 -0.11 N/A

C11orf58 ENST00000228136.4 chromosome 11 open reading frame 58 1782 1 0 1 0 0 hsa-miR-4498 -0.01 -0.26 N/A

UFC1 ENST00000368003.5 ubiquitin-fold modifier conjugating enzyme 1 519 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.25 N/A

MAP2K2 ENST00000262948.5 mitogen-activated protein kinase kinase 2 159 3 1 1 1 1 hsa-miR-5001-5p -0.01 -0.47 N/A translocase of outer mitochondrial membrane 20 homolog TOMM20 ENST00000366607.4 674 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.05 N/A (yeast) DMD ENST00000378677.2 dystrophin 211 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.05 N/A

PTPDC1 ENST00000375360.3 protein tyrosine phosphatase domain containing 1 46 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.07 N/A

NEK4 ENST00000233027.5 NIMA-related kinase 4 288 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.11 N/A

SOX11 ENST00000322002.3 SRY (sex determining region Y)-box 11 1100 2 0 2 0 1 hsa-miR-4492 -0.01 -0.04 N/A LSM3 homolog, U6 small nuclear RNA associated (S. LSM3 ENST00000306024.3 304 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.17 N/A cerevisiae) nuclear fragile X mental retardation protein interacting NUFIP2 ENST00000225388.4 440 1 0 1 0 0 hsa-miR-4498 -0.01 -0.05 N/A protein 2 FOXG1 ENST00000382535.3 forkhead box G1 40 1 0 0 1 0 hsa-miR-4498 -0.01 -0.06 N/A

USP9X ENST00000324545.8 ubiquitin specific peptidase 9, X-linked 2433 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.1 N/A

SV2C ENST00000502798.2 synaptic vesicle glycoprotein 2C 30 1 0 0 1 1 hsa-miR-4492 -0.01 -0.01 N/A

ENPEP ENST00000265162.5 glutamyl aminopeptidase (aminopeptidase A) 10 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.02 N/A membrane-associated ring finger (C3HC4) 7, E3 ubiquitin MARCH7 ENST00000259050.4 537 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.13 N/A protein ligase GPKOW ENST00000156109.5 G patch domain and KOW motifs 420 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.24 N/A

NOL11 ENST00000253247.4 nucleolar protein 11 271 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.18 N/A

FUNDC2 ENST00000369498.3 FUN14 domain containing 2 130 2 0 0 2 0 hsa-miR-5001-5p -0.01 -0.23 N/A RRN3 RNA polymerase I transcription factor homolog (S. RRN3 ENST00000198767.6 470 1 0 1 0 0 hsa-miR-4498 -0.01 -0.11 N/A cerevisiae) CRISPLD2 ENST00000262424.5 cysteine-rich secretory protein LCCL domain containing 2 397 3 0 2 1 4 hsa-miR-5001-5p -0.01 -0.51 N/A

SNX2 ENST00000379516.2 sorting nexin 2 397 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.13 N/A

USP49 ENST00000394253.3 ubiquitin specific peptidase 49 44 1 0 1 0 0 hsa-miR-4498 -0.01 -0.03 N/A

ZNF766 ENST00000439461.1 zinc finger protein 766 324 1 0 1 0 0 hsa-miR-4498 -0.01 -0.11 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score MED9 ENST00000268711.3 mediator complex subunit 9 256 1 0 1 0 1 hsa-miR-4498 -0.01 -0.26 N/A TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member TBC1D1 ENST00000261439.4 150 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.12 N/A 1 ZNF860 ENST00000360311.4 zinc finger protein 860 85 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.17 N/A

EIF1AD ENST00000526451.1 eukaryotic translation initiation factor 1A domain containing 359 1 0 1 0 1 hsa-miR-4498 -0.01 -0.37 N/A

TMED4 ENST00000457408.2 transmembrane emp24 protein transport domain containing 4 3117 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.42 N/A

PHF21A ENST00000257821.4 PHD finger protein 21A 301 2 0 1 1 2 hsa-miR-4498 -0.01 -0.12 N/A

MTMR3 ENST00000333027.3 myotubularin related protein 3 123 2 1 0 1 0 hsa-miR-4492 -0.01 -0.04 N/A

ALG9 ENST00000531154.1 ALG9, alpha-1,2-mannosyltransferase 586 2 0 1 1 0 hsa-miR-5001-5p -0.01 -0.2 N/A

JRKL ENST00000458427.1 jerky homolog-like (mouse) 116 1 0 0 1 0 hsa-miR-4498 -0.01 -0.14 N/A

KIAA0319 ENST00000537886.1 KIAA0319 12 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

RANBP6 ENST00000259569.5 RAN binding protein 6 117 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.26 N/A

RAB24 ENST00000393611.2 RAB24, member RAS oncogene family 908 1 0 1 0 0 hsa-miR-4498 -0.01 -0.28 N/A

ARHGAP29 ENST00000260526.6 Rho GTPase activating protein 29 451 1 0 1 0 0 hsa-miR-4498 -0.01 -0.14 N/A

HHIP ENST00000296575.3 hedgehog interacting protein 65 1 0 1 0 0 hsa-miR-4492 -0.01 -0.02 N/A

XPO5 ENST00000265351.7 exportin 5 933 1 0 0 1 2 hsa-miR-5001-5p -0.01 -0.15 N/A

RPAP2 ENST00000610020.1 RNA polymerase II associated protein 2 222 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.29 N/A

DDX52 ENST00000349699.2 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 865 2 0 1 1 0 hsa-miR-5001-5p -0.01 -0.12 N/A

TBC1D10B ENST00000409939.3 TBC1 domain family, member 10B 174 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.02 N/A

RFC2 ENST00000352131.3 replication factor C (activator 1) 2, 40kDa 411 2 0 2 0 1 hsa-miR-4498 -0.01 -0.31 N/A

MRPS14 ENST00000476371.1 mitochondrial ribosomal protein S14 2140 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.17 N/A

ECHDC3 ENST00000379215.4 enoyl CoA hydratase domain containing 3 315 3 3 0 0 1 hsa-miR-5001-5p -0.01 -0.72 N/A

SIX4 ENST00000216513.4 SIX homeobox 4 94 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

RBM4B ENST00000531036.2 RNA binding motif protein 4B 199 1 0 1 0 0 hsa-miR-4498 -0.01 -0.14 N/A

LHFPL4 ENST00000287585.6 lipoma HMGIC fusion partner-like 4 6 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.05 N/A

NADK ENST00000341426.5 NAD kinase 173 1 0 1 0 0 hsa-miR-4498 -0.01 -0.25 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NTPCR ENST00000366628.5 nucleoside-triphosphatase, cancer-related 2755 4 0 2 2 3 hsa-miR-4498 -0.01 -0.48 N/A

TEX2 ENST00000258991.3 testis expressed 2 127 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.18 N/A

DCTN6 ENST00000221114.3 dynactin 6 745 2 1 0 1 1 hsa-miR-5001-5p -0.01 -0.3 N/A

IMPA2 ENST00000269159.3 inositol(myo)-1(or 4)-monophosphatase 2 2916 1 0 1 0 0 hsa-miR-4498 -0.01 -0.17 N/A

ZBTB25 ENST00000608382.1 zinc finger and BTB domain containing 25 149 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.06 N/A

TUSC2 ENST00000232496.4 tumor suppressor candidate 2 611 1 0 1 0 0 hsa-miR-4498 -0.01 -0.29 N/A

AUTS2 ENST00000342771.4 autism susceptibility candidate 2 198 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.05 N/A

NOTCH1 ENST00000277541.6 notch 1 88 1 0 1 0 1 hsa-miR-4498 -0.01 -0.02 N/A

SYNM ENST00000560674.1 synemin, intermediate filament protein 36 1 0 0 1 0 hsa-miR-4492 -0.01 -0.01 N/A

CAPN7 ENST00000253693.2 calpain 7 76 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.36 N/A

C12orf5 ENST00000179259.4 chromosome 12 open reading frame 5 520 2 0 1 1 1 hsa-miR-4498 -0.01 -0.26 N/A

FAM204A ENST00000369183.4 family with sequence similarity 204, member A 296 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.13 N/A

KLRG2 ENST00000340940.4 killer cell lectin-like receptor subfamily G, member 2 18 1 0 1 0 1 hsa-miR-4498 -0.01 -0.02 N/A

UBE2I ENST00000355803.4 ubiquitin-conjugating enzyme E2I 291 1 0 1 0 2 hsa-miR-4498 -0.01 -0.17 N/A

CCDC59 ENST00000256151.7 coiled-coil domain containing 59 140 2 1 0 1 0 hsa-miR-5001-5p -0.01 -0.32 N/A solute carrier family 22 (organic cation transporter), member SLC22A3 ENST00000392145.1 86 1 0 1 0 1 hsa-miR-4498 -0.01 -0.11 N/A 3 AP1S1 ENST00000337619.5 adaptor-related protein complex 1, sigma 1 subunit 750 1 0 1 0 0 hsa-miR-4498 -0.01 -0.26 N/A

ZNF555 ENST00000334241.4 zinc finger protein 555 64 1 0 0 1 2 hsa-miR-5001-5p -0.01 -0.08 N/A

KB-1507C5.2 ENST00000524007.1 HCG15011, isoform CRA_a; Protein LOC100996457 103 1 1 0 0 0 hsa-miR-4498 -0.01 -0.49 N/A

KCMF1 ENST00000409785.4 potassium channel modulatory factor 1 1285 3 2 1 0 0 hsa-miR-4498 -0.01 -0.59 N/A

TMEM242 ENST00000400788.4 transmembrane protein 242 593 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.08 N/A

DLL4 ENST00000249749.5 delta-like 4 (Drosophila) 605 1* 0 0 0 1 hsa-miR-4498 -0.01 -0.01 N/A tankyrase, TRF1-interacting ankyrin-related ADP-ribose TNKS2 ENST00000371627.4 205 1 1 0 0 0 hsa-miR-4498 -0.01 -0.18 N/A polymerase 2 ZNF100 ENST00000358296.6 zinc finger protein 100 142 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.09 N/A

AGPS ENST00000264167.4 alkylglycerone phosphate synthase 1610 1 0 1 0 0 hsa-miR-4498 -0.01 -0.08 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score ENTPD7 ENST00000370489.4 ectonucleoside triphosphate diphosphohydrolase 7 136 1 0 1 0 2 hsa-miR-4498 -0.01 -0.05 N/A

VPS13D ENST00000358136.3 vacuolar protein sorting 13 homolog D (S. cerevisiae) 290 1 0 1 0 2 hsa-miR-4492 -0.01 -0.02 N/A

THBS2 ENST00000366787.3 thrombospondin 2 372 2 0 2 0 3 hsa-miR-5001-5p -0.01 -0.2 N/A

TNIK ENST00000436636.2 TRAF2 and NCK interacting kinase 106 1 0 1 0 0 hsa-miR-4498 -0.01 -0.1 N/A

DDB2 ENST00000378601.3 damage-specific DNA binding protein 2, 48kDa 198 2 1 1 0 0 hsa-miR-5001-5p -0.01 -0.42 N/A

TJP1 ENST00000346128.6 tight junction protein 1 140 1 0 1 0 0 hsa-miR-4498 -0.01 -0.17 N/A

SESN3 ENST00000536441.1 sestrin 3 260 1 0 0 1 0 hsa-miR-5001-5p -0.01 -0.09 N/A

MPV17L ENST00000396385.3 MPV17 mitochondrial membrane protein-like 23 1 0 0 1 1 hsa-miR-4498 -0.01 -0.12 N/A

DDX54 ENST00000314045.7 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 1332 3 1 2 0 2 hsa-miR-4498 -0.01 -0.27 N/A

SMC2 ENST00000374793.3 structural maintenance of chromosomes 2 212 1 0 1 0 0 hsa-miR-4498 -0.01 -0.11 N/A

RBM15B ENST00000323686.4 RNA binding motif protein 15B 1925 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.14 N/A

CFD ENST00000327726.6 complement factor D (adipsin) 58 1 0 1 0 0 hsa-miR-4498 -0.01 -0.1 N/A

RFC5 ENST00000229043.3 replication factor C (activator 1) 5, 36.5kDa 1328 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.16 N/A

HSD17B12 ENST00000278353.4 hydroxysteroid (17-beta) dehydrogenase 12 1422 1 0 1 0 1 hsa-miR-4498 -0.01 -0.04 N/A X-ray repair complementing defective repair in Chinese XRCC5 ENST00000392133.3 14802 5 1 4 0 3 hsa-miR-4498 -0.01 -0.44 N/A hamster cells 5 (double-strand-break rejoining) HDLBP ENST00000391975.1 high density lipoprotein binding protein 1755 1 0 1 0 4 hsa-miR-5001-5p -0.01 -0.02 N/A

RBFA ENST00000262197.7 ribosome binding factor A (putative) 131 1 0 1 0 0 hsa-miR-4498 -0.01 -0.14 N/A

TXNDC16 ENST00000281741.4 thioredoxin domain containing 16 508 1 0 1 0 0 hsa-miR-4498 -0.01 -0.26 N/A

HLA-A ENST00000396634.1 major histocompatibility complex, class I, A 276 1 0 0 1 2 hsa-miR-4498 -0.01 -0.15 N/A

CD248 ENST00000311330.3 CD248 molecule, endosialin 439 2 0 1 1 1 hsa-miR-4492 -0.01 -0.03 N/A

PCSK7 ENST00000320934.3 proprotein convertase subtilisin/kexin type 7 92 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.1 N/A

POMT2 ENST00000261534.4 protein-O-mannosyltransferase 2 526 1 0 1 0 1 hsa-miR-4498 -0.01 -0.15 N/A

C11orf30 ENST00000529032.1 chromosome 11 open reading frame 30 230 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.12 N/A

PARG ENST00000402038.3 poly (ADP-ribose) glycohydrolase 445 1 0 0 1 1 hsa-miR-5001-5p -0.01 -0.1 N/A

CHST7 ENST00000276055.3 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 406 1 0 1 0 0 hsa-miR-4498 -0.01 -0.19 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PIK3C3 ENST00000262039.4 phosphatidylinositol 3-kinase, catalytic subunit type 3 286 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.03 N/A excision repair cross-complementing rodent repair ERCC6L2 ENST00000407474.3 118 1 0 1 0 4 hsa-miR-4498 -0.01 -0.07 N/A deficiency, complementation group 6-like 2 HOXA9 ENST00000396345.1 homeobox A9 151 1 0 1 0 1 hsa-miR-5001-5p -0.01 -0.28 N/A

UNKL ENST00000389221.4 unkempt homolog (Drosophila)-like 308 1 0 1 0 0 hsa-miR-5001-5p -0.01 -0.06 N/A

CTSV ENST00000259470.5 cathepsin V 601 1 0 1 0 1 hsa-miR-4498 -0.01 -0.17 N/A

FLYWCH1 ENST00000253928.9 FLYWCH-type zinc finger 1 97 1 0 1 0 1 hsa-miR-4498 -0.01 -0.1 N/A

RP1-170O19.20 ENST00000470747.4 Uncharacterized protein 151 1 0 1 0 1 hsa-miR-4498 -0.01 -0.28 N/A

MSH6 ENST00000234420.5 mutS homolog 6 94 1 1 0 0 0 hsa-miR-5001-5p -0.01 -0.07 N/A

SLC45A4 ENST00000519067.1 solute carrier family 45, member 4 418 2 1 1 0 1 hsa-miR-4498 -0.01 -0.07 N/A

SRSF9 ENST00000229390.3 serine/arginine-rich splicing factor 9 946 1 1 0 0 0 hsa-miR-5001-5p 0 -0.33 N/A

TPT1 ENST00000379056.1 tumor protein, translationally-controlled 1 2856 1 0 1 0 0 hsa-miR-4498 0 -0.24 N/A

NDUFV3 ENST00000340344.4 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 1449 1 0 0 1 1 hsa-miR-5001-5p 0 -0.29 N/A

PRKD2 ENST00000601806.1 protein kinase D2 287 2* 0 1 0 0 hsa-miR-4498 0 -0.21 N/A

USP3 ENST00000380324.3 ubiquitin specific peptidase 3 583 1 0 1 0 0 hsa-miR-4498 0 -0.23 N/A pleckstrin homology domain containing, family G (with PLEKHG3 ENST00000247226.7 97 2 0 2 0 0 hsa-miR-4498 0 -0.1 N/A RhoGef domain) member 3 ZDHHC5 ENST00000287169.3 zinc finger, DHHC-type containing 5 1505 1 0 0 1 0 hsa-miR-4498 0 -0.08 N/A

FIBP ENST00000338369.2 fibroblast growth factor (acidic) intracellular binding protein 2477 1 0 0 1 0 hsa-miR-5001-5p 0 -0.23 N/A

FLRT2 ENST00000330753.4 fibronectin leucine rich transmembrane protein 2 73 1 0 0 1 0 hsa-miR-5001-5p 0 -0.02 N/A small nuclear RNA activating complex, polypeptide 3, SNAPC3 ENST00000380821.3 2406 1 1 0 0 0 hsa-miR-4498 0 -0.32 N/A 50kDa ZNF226 ENST00000588883.1 zinc finger protein 226 327 1 0 0 1 0 hsa-miR-5001-5p 0 -0.17 N/A

APLF ENST00000303795.4 aprataxin and PNKP like factor 57 1 0 1 0 0 hsa-miR-5001-5p 0 -0.18 N/A

BRD7 ENST00000394688.3 bromodomain containing 7 349 1 0 1 0 2 hsa-miR-4498 0 -0.22 N/A

FCHSD1 ENST00000435817.2 FCH and double SH3 domains 1 364 1 1 0 0 2 hsa-miR-5001-5p 0 -0.14 N/A

IGSF3 ENST00000369486.3 immunoglobulin superfamily, member 3 141 1 0 1 0 1 hsa-miR-4498 0 -0.14 N/A

AMACR ENST00000335606.6 alpha-methylacyl-CoA racemase 308 1 1 0 0 0 hsa-miR-5001-5p 0 -0.3 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score G protein-coupled receptor 37 (endothelin receptor type B- GPR37 ENST00000303921.2 395 1 0 0 1 0 hsa-miR-4498 0 -0.08 N/A like) CLCC1 ENST00000356970.2 chloride channel CLIC-like 1 849 2 1 0 1 0 hsa-miR-4498 0 -0.36 N/A

HCFC2 ENST00000229330.4 host cell factor C2 46 1 1 0 0 1 hsa-miR-4498 0 -0.1 N/A

MRPL12 ENST00000333676.3 mitochondrial ribosomal protein L12 2476 4 2 1 1 2 hsa-miR-5001-5p 0 -0.55 N/A

SCO1 ENST00000255390.5 SCO1 cytochrome c oxidase assembly protein 1776 2 1 0 1 2 hsa-miR-5001-5p 0 -0.41 N/A

HSD17B8 ENST00000374662.3 hydroxysteroid (17-beta) dehydrogenase 8 51 1 0 0 1 0 hsa-miR-5001-5p 0 -0.1 N/A

GPATCH2 ENST00000366935.3 G patch domain containing 2 108 1 0 1 0 0 hsa-miR-4498 0 -0.02 N/A ArfGAP with RhoGAP domain, ankyrin repeat and PH ARAP1 ENST00000359373.5 253 1 0 1 0 3 hsa-miR-4498 0 -0.07 N/A domain 1 C22orf29 ENST00000407472.1 chromosome 22 open reading frame 29 351 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

ELAVL1 ENST00000407627.2 ELAV like RNA binding protein 1 2812 2 0 0 2 2 hsa-miR-5001-5p 0 -0.2 N/A

CSNK1D ENST00000392334.2 casein kinase 1, delta 1799 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

TGIF1 ENST00000330513.5 TGFB-induced factor homeobox 1 354 1 0 1 0 0 hsa-miR-4498 0 -0.18 N/A

ALS2CL ENST00000318962.4 ALS2 C-terminal like 201 1 1 0 0 0 hsa-miR-5001-5p 0 -0.18 N/A sperm antigen with calponin homology and coiled-coil SPECC1 ENST00000395530.2 128 2 0 2 0 0 hsa-miR-5001-5p 0 -0.11 N/A domains 1 solute carrier family 47 (multidrug and toxin extrusion), SLC47A1 ENST00000270570.4 204 2 0 2 0 0 hsa-miR-4498 0 -0.12 N/A member 1 TMBIM4 ENST00000398033.4 transmembrane BAX inhibitor motif containing 4 1749 1 0 0 1 0 hsa-miR-5001-5p 0 -0.16 N/A

SPRYD4 ENST00000338146.5 SPRY domain containing 4 1999 1 0 0 1 1 hsa-miR-5001-5p 0 -0.21 N/A solute carrier family 1 (neutral amino acid transporter), SLC1A5 ENST00000542575.2 681 1 0 1 0 0 hsa-miR-4498 0 -0.24 N/A member 5 FLYWCH2 ENST00000396958.3 FLYWCH family member 2 720 1 0 1 0 0 hsa-miR-5001-5p 0 -0.23 N/A

PCDHB2 ENST00000194155.4 protocadherin beta 2 199 1 1 0 0 0 hsa-miR-4498 0 -0.4 N/A

ACO1 ENST00000309951.6 aconitase 1, soluble 738 1 0 0 1 0 hsa-miR-5001-5p 0 -0.14 N/A

ZFP30 ENST00000392144.1 ZFP30 zinc finger protein 41 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

GFPT1 ENST00000357308.4 glutamine--fructose-6-phosphate transaminase 1 1313 1 0 0 1 0 hsa-miR-4498 0 -0.08 N/A

CTNNBL1 ENST00000361383.6 catenin, beta like 1 206 1 0 0 1 1 hsa-miR-4498 0 -0.22 N/A

NCKAP1 ENST00000361354.4 NCK-associated protein 1 700 3 1 1 1 2 hsa-miR-5001-5p 0 -0.45 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score POLA2 ENST00000265465.3 polymerase (DNA directed), alpha 2, accessory subunit 2627 2 0 1 1 2 hsa-miR-4498 0 -0.33 N/A

C14orf93 ENST00000299088.6 chromosome 14 open reading frame 93 212 1 0 0 1 0 hsa-miR-5001-5p 0 -0.14 N/A

CYB5R4 ENST00000369681.5 cytochrome b5 reductase 4 329 1 1 0 0 0 hsa-miR-5001-5p 0 -0.27 N/A

TRMT10C ENST00000309922.6 tRNA methyltransferase 10 homolog C (S. cerevisiae) 655 2 1 0 1 0 hsa-miR-5001-5p 0 -0.47 N/A

ALG14 ENST00000370205.5 ALG14, UDP-N-acetylglucosaminyltransferase subunit 572 2 0 2 0 1 hsa-miR-4498 0 -0.52 N/A establishment of sister chromatid cohesion N- ESCO1 ENST00000269214.5 94 1 0 0 1 1 hsa-miR-4498 0 -0.06 N/A acetyltransferase 1 HAUS3 ENST00000243706.4 HAUS augmin-like complex, subunit 3 466 1 0 0 1 0 hsa-miR-4498 0 -0.07 N/A

DNAJC15 ENST00000379221.2 DnaJ (Hsp40) homolog, subfamily C, member 15 3290 1 0 1 0 0 hsa-miR-4498 0 -0.19 N/A

WWC2 ENST00000403733.3 WW and C2 domain containing 2 717 2 2 0 0 0 hsa-miR-5001-5p 0 -0.31 N/A

TADA3 ENST00000301964.2 transcriptional adaptor 3 135 1 0 0 1 0 hsa-miR-4498 0 -0.1 N/A

TUBD1 ENST00000346141.6 tubulin, delta 1 157 2 0 2 0 0 hsa-miR-4498 0 -0.44 N/A

ZNF480 ENST00000490272.1 zinc finger protein 480 239 1 0 0 1 0 hsa-miR-5001-5p 0 -0.18 N/A

GLI4 ENST00000523522.1 GLI family zinc finger 4 231 3 0 3 0 5 hsa-miR-4498 0 -0.31 N/A

DAK ENST00000394900.3 dihydroxyacetone kinase 2 homolog (S. cerevisiae) 242 2 0 2 0 1 hsa-miR-4498 0 -0.16 N/A

CACYBP ENST00000367681.2 calcyclin binding protein 374 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A

HIST1H1C ENST00000343677.2 histone cluster 1, H1c 1852 1 0 1 0 0 hsa-miR-4498 0 -0.26 N/A

MDH2 ENST00000315758.5 malate dehydrogenase 2, NAD (mitochondrial) 9055 2 0 0 2 0 hsa-miR-5001-5p 0 -0.2 N/A

OBFC1 ENST00000224950.3 oligonucleotide/oligosaccharide-binding fold containing 1 184 1 1 0 0 0 hsa-miR-4498 0 -0.15 N/A

NEGR1 ENST00000357731.5 neuronal growth regulator 1 28 1 0 0 1 0 hsa-miR-5001-5p 0 -0.02 N/A

STMN1 ENST00000455785.2 stathmin 1 30059 1 0 0 1 0 hsa-miR-4498 0 -0.17 N/A

MOV10 ENST00000413052.2 Mov10, Moloney leukemia virus 10, homolog (mouse) 248 1 0 1 0 1 hsa-miR-4498 0 -0.13 N/A

DNAJC10 ENST00000264065.7 DnaJ (Hsp40) homolog, subfamily C, member 10 709 1 0 0 1 1 hsa-miR-4498 0 -0.3 N/A

SRFBP1 ENST00000339397.4 serum response factor binding protein 1 102 1 0 0 1 0 hsa-miR-5001-5p 0 -0.12 N/A

NPEPPS ENST00000322157.4 aminopeptidase puromycin sensitive 2194 1 0 1 0 1 hsa-miR-4498 0 -0.32 N/A

MAP7 ENST00000354570.3 microtubule-associated protein 7 444 2 0 2 0 0 hsa-miR-4498 0 -0.34 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score QSOX1 ENST00000367602.3 quiescin Q6 sulfhydryl oxidase 1 9246 2 0 2 0 5 hsa-miR-4498 0 -0.2 N/A carbamoyl-phosphate synthetase 2, aspartate CAD ENST00000264705.4 689 1 0 1 0 0 hsa-miR-5001-5p 0 -0.16 N/A transcarbamylase, and dihydroorotase ZNF670 ENST00000366503.2 zinc finger protein 670 117 1 0 0 1 0 hsa-miR-5001-5p 0 -0.16 N/A

DGKI ENST00000453654.2 diacylglycerol kinase, iota 16 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

TSPYL1 ENST00000368608.3 TSPY-like 1 2195 3 1 0 2 1 hsa-miR-5001-5p 0 -0.42 N/A

DNAJC30 ENST00000395176.2 DnaJ (Hsp40) homolog, subfamily C, member 30 766 2 0 1 1 1 hsa-miR-5001-5p 0 -0.42 N/A

MFSD11 ENST00000336509.4 major facilitator superfamily domain containing 11 142 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A

PPIP5K2 ENST00000321521.9 diphosphoinositol pentakisphosphate kinase 2 203 2 1 1 0 0 hsa-miR-4492 0 -0.05 N/A

KRT19 ENST00000361566.3 keratin 19 142 1 0 0 1 0 hsa-miR-4498 0 -0.2 N/A

BAMBI ENST00000375533.3 BMP and activin membrane-bound inhibitor 515 1 0 1 0 0 hsa-miR-4498 0 -0.09 N/A

CEP120 ENST00000306467.5 centrosomal protein 120kDa 261 1 0 1 0 0 hsa-miR-4498 0 -0.16 N/A

PIGH ENST00000216452.4 phosphatidylinositol glycan anchor biosynthesis, class H 107 1 0 1 0 0 hsa-miR-5001-5p 0 -0.23 N/A

HPS1 ENST00000361490.4 Hermansky-Pudlak syndrome 1 382 1 0 1 0 1 hsa-miR-4498 0 -0.21 N/A

POLR2L ENST00000322028.4 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa 11355 2 0 1 1 0 hsa-miR-5001-5p 0 -0.5 N/A

GAPVD1 ENST00000470056.1 GTPase activating protein and VPS9 domains 1 1805 1 0 0 1 2 hsa-miR-5001-5p 0 -0.05 N/A

WDR3 ENST00000349139.5 WD repeat domain 3 1166 1 0 0 1 1 hsa-miR-4498 0 -0.09 N/A

OLFM2 ENST00000264833.4 olfactomedin 2 65 1 0 1 0 1 hsa-miR-4492 0 -0.02 N/A excision repair cross-complementing rodent repair ERCC6L ENST00000373657.1 82 1 0 1 0 2 hsa-miR-5001-5p 0 -0.04 N/A deficiency, complementation group 6-like solute carrier family 16 (monocarboxylate transporter), SLC16A1 ENST00000369626.3 707 1 0 1 0 0 hsa-miR-4498 0 -0.15 N/A member 1 FOSL2 ENST00000379619.1 FOS-like antigen 2 2255 1 0 1 0 4 hsa-miR-5001-5p 0 -0.12 N/A

ETV1 ENST00000430479.1 ets variant 1 160 1 0 1 0 0 hsa-miR-4498 0 -0.09 N/A

SNRNP35 ENST00000526639.2 small nuclear ribonucleoprotein 35kDa (U11/U12) 238 1 0 1 0 0 hsa-miR-4498 0 -0.22 N/A

CLNS1A ENST00000525428.1 chloride channel, nucleotide-sensitive, 1A 553 1 0 0 1 0 hsa-miR-4498 0 -0.14 N/A

CHSY1 ENST00000254190.3 chondroitin sulfate synthase 1 200 3 1 2 0 1 hsa-miR-4498 0 -0.11 N/A

SLC35E3 ENST00000398004.2 solute carrier family 35, member E3 250 1 0 1 0 0 hsa-miR-4498 0 -0.07 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score NSUN4 ENST00000474844.1 NOP2/Sun domain family, member 4 422 1 1 0 0 0 hsa-miR-5001-5p 0 -0.31 N/A

AP5Z1 ENST00000348624.4 adaptor-related protein complex 5, zeta 1 subunit 467 4 2 1 1 6 hsa-miR-5001-5p 0 -0.31 N/A eukaryotic translation initiation factor 2B, subunit 3 gamma, EIF2B3 ENST00000360403.2 901 2 0 1 1 3 hsa-miR-5001-5p 0 -0.42 N/A 58kDa C7orf55-LUC7L2 ENST00000354926.4 C7orf55-LUC7L2 readthrough 419 1 1 0 0 0 hsa-miR-5001-5p 0 -0.39 N/A

COX6B1 ENST00000246554.3 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 1779 2 1 0 1 1 hsa-miR-4498 0 -1 N/A

LUC7L2 ENST00000541515.3 LUC7-like 2 (S. cerevisiae) 419 1 1 0 0 0 hsa-miR-5001-5p 0 -0.38 N/A

ADARB1 ENST00000539173.1 adenosine deaminase, RNA-specific, B1 860 1 0 1 0 2 hsa-miR-5001-5p 0 -0.03 N/A

CENPF ENST00000366955.3 centromere protein F, 350/400kDa 181 1 1 0 0 0 hsa-miR-4492 0 -0.03 N/A

SNAP47 ENST00000366760.1 synaptosomal-associated protein, 47kDa 7416 1 0 0 1 0 hsa-miR-5001-5p 0 -0.16 N/A

NCKIPSD ENST00000416649.2 NCK interacting protein with SH3 domain 4158 4 0 3 1 0 hsa-miR-4498 0 -0.6 N/A

IGSF10 ENST00000282466.3 immunoglobulin superfamily, member 10 191 1 1 0 0 0 hsa-miR-5001-5p 0 -0.1 N/A

SART1 ENST00000312397.5 squamous cell carcinoma antigen recognized by T cells 94 1 0 0 1 0 hsa-miR-5001-5p 0 -0.05 N/A

BAIAP2L1 ENST00000005260.8 BAI1-associated protein 2-like 1 1118 2 0 2 0 0 hsa-miR-4498 0 -0.13 N/A

CFL2 ENST00000341223.3 cofilin 2 (muscle) 902 1 0 0 1 0 hsa-miR-5001-5p 0 -0.14 N/A

ATP6V1E1 ENST00000253413.5 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 2139 1 1 0 0 1 hsa-miR-4498 0 -0.31 N/A fragile site, folic acid type, rare, fra(10)(q23.3) or FRA10AC1 ENST00000536233.1 289 1 0 1 0 0 hsa-miR-4498 0 -0.24 N/A fra(10)(q24.2) candidate 1 VTA1 ENST00000367630.4 vesicle (multivesicular body) trafficking 1 1424 1 1 0 0 0 hsa-miR-4498 0 -0.26 N/A

CEP63 ENST00000337090.3 centrosomal protein 63kDa 191 1 0 1 0 1 hsa-miR-4498 0 -0.09 N/A

GFRA1 ENST00000439649.3 GDNF family receptor alpha 1 69 1 1 0 0 1 hsa-miR-4492 0 -0.03 N/A amyloid beta (A4) precursor protein-binding, family B, APBB2 ENST00000295974.8 704 1 1 0 0 0 hsa-miR-5001-5p 0 -0.34 N/A member 2 TIMELESS ENST00000229201.4 timeless circadian clock 3085 1 0 1 0 0 hsa-miR-4498 0 -0.14 N/A

C3 ENST00000245907.6 complement component 3 932 1 0 1 0 1 hsa-miR-5001-5p 0 -0.14 N/A

MATN2 ENST00000254898.5 matrilin 2 371 1 0 0 1 0 hsa-miR-4498 0 -0.17 N/A

ODC1 ENST00000234111.4 ornithine decarboxylase 1 999 1 0 0 1 0 hsa-miR-5001-5p 0 -0.14 N/A

ZNF146 ENST00000443387.2 zinc finger protein 146 3086 1 0 1 0 0 hsa-miR-4498 0 -0.36 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SLC38A9 ENST00000396865.2 solute carrier family 38, member 9 156 1 0 0 1 1 hsa-miR-5001-5p 0 -0.02 N/A

LIG3 ENST00000378526.4 ligase III, DNA, ATP-dependent 554 1 0 1 0 2 hsa-miR-4498 0 -0.04 N/A

VPS8 ENST00000287546.4 vacuolar protein sorting 8 homolog (S. cerevisiae) 120 1 0 0 1 0 hsa-miR-5001-5p 0 -0.04 N/A

GUCY1A2 ENST00000526355.2 guanylate cyclase 1, soluble, alpha 2 24 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

RNF213 ENST00000582970.1 ring finger protein 213 630 2 0 0 2 4 hsa-miR-5001-5p 0 -0.27 N/A

SMIM8 ENST00000392863.1 small integral membrane protein 8 449 1 0 1 0 0 hsa-miR-4498 0 -0.26 N/A

APP ENST00000346798.3 amyloid beta (A4) precursor protein 4570 2 0 1 1 0 hsa-miR-4498 0 -0.19 N/A

ZMYM2 ENST00000382869.3 zinc finger, MYM-type 2 172 2 0 1 1 0 hsa-miR-4498 0 -0.07 N/A

PHAX ENST00000297540.4 phosphorylated adaptor for RNA export 309 1 0 1 0 0 hsa-miR-4498 0 -0.28 N/A

RPS23 ENST00000296674.8 ribosomal protein S23 832 2 0 2 0 1 hsa-miR-4498 0 -0.37 N/A solute carrier family 2 (facilitated glucose transporter), SLC2A4 ENST00000317370.8 233 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A member 4 STK24 ENST00000397517.2 serine/threonine kinase 24 486 1 0 1 0 2 hsa-miR-5001-5p 0 -0.13 N/A ATP synthase, H+ transporting, mitochondrial F1 complex, ATP5A1 ENST00000282050.2 690 1 0 1 0 0 hsa-miR-5001-5p 0 -0.22 N/A alpha subunit 1, cardiac muscle OTUB1 ENST00000538426.1 OTU domain, ubiquitin aldehyde binding 1 2977 1 0 1 0 1 hsa-miR-5001-5p 0 -0.23 N/A

EPB41L1 ENST00000441639.1 erythrocyte membrane protein band 4.1-like 1 369 1 0 0 1 0 hsa-miR-5001-5p 0 -0.14 N/A

JUN ENST00000371222.2 jun proto-oncogene 7432 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A

MYO1G ENST00000258787.7 myosin IG 5 2 0 2 0 31 hsa-miR-4498 0 -1.61 N/A

PIN1 ENST00000247970.4 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 934 2 1 1 0 0 hsa-miR-4498 0 -0.55 N/A

LETM1 ENST00000302787.2 leucine zipper-EF-hand containing transmembrane protein 1 198 1 0 0 1 1 hsa-miR-5001-5p 0 -0.01 N/A

KIAA0195 ENST00000314256.7 KIAA0195 810 1 0 0 1 0 hsa-miR-5001-5p 0 -0.15 N/A

CMBL ENST00000296658.3 carboxymethylenebutenolidase homolog (Pseudomonas) 2602 1 1 0 0 1 hsa-miR-5001-5p 0 -0.24 N/A

PPP1R15A ENST00000200453.5 protein phosphatase 1, regulatory subunit 15A 2130 4 1 1 2 0 hsa-miR-5001-5p 0 -0.59 N/A

CHD9 ENST00000566029.1 chromodomain helicase DNA binding protein 9 447 2 0 0 2 0 hsa-miR-5001-5p 0 -0.15 N/A

FOCAD ENST00000380249.1 focadhesin 347 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A tRNA 5-methylaminomethyl-2-thiouridylate TRMU ENST00000381019.3 150 1 0 0 1 2 hsa-miR-5001-5p 0 -0.11 N/A methyltransferase Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PNO1 ENST00000263657.2 partner of NOB1 homolog (S. cerevisiae) 554 1 1 0 0 0 hsa-miR-4498 0 -0.33 N/A

GRWD1 ENST00000253237.5 glutamate-rich WD repeat containing 1 2673 4 1 3 0 4 hsa-miR-4498 0 -0.39 N/A

GALT ENST00000378842.3 galactose-1-phosphate uridylyltransferase 1012 1 1 0 0 0 hsa-miR-5001-5p 0 -0.37 N/A

SLC44A1 ENST00000374720.3 solute carrier family 44 (choline transporter), member 1 407 1 1 0 0 1 hsa-miR-4492 0 -0.03 N/A

RCAN1 ENST00000482533.1 regulator of calcineurin 1 715 1 1 0 0 1 hsa-miR-4498 0 -0.22 N/A

ULK2 ENST00000395544.4 unc-51 like autophagy activating kinase 2 489 3 1 2 0 0 hsa-miR-5001-5p 0 -0.13 N/A

XPO4 ENST00000400602.2 exportin 4 718 1 0 0 1 0 hsa-miR-4498 0 -0.09 N/A

MRP63 ENST00000309594.4 mitochondrial ribosomal protein 63 1352 1 1 0 0 0 hsa-miR-4498 0 -0.47 N/A

PPIG ENST00000260970.3 peptidylprolyl isomerase G (cyclophilin G) 470 1 1 0 0 0 hsa-miR-5001-5p 0 -0.25 N/A

LGALS8 ENST00000526589.1 lectin, galactoside-binding, soluble, 8 188 1 0 1 0 1 hsa-miR-4492 0 -0.02 N/A

SERTAD1 ENST00000357949.4 SERTA domain containing 1 603 1 0 0 1 1 hsa-miR-5001-5p 0 -0.19 N/A

BCAS4 ENST00000371608.2 breast carcinoma amplified sequence 4 492 3* 0 1 1 2 hsa-miR-5001-5p 0 -0.3 N/A

EIF4E ENST00000450253.2 eukaryotic translation initiation factor 4E 876 1 1 0 0 0 hsa-miR-5001-5p 0 -0.3 N/A isoamyl acetate-hydrolyzing esterase 1 homolog (S. IAH1 ENST00000470914.1 553 1 0 0 1 1 hsa-miR-4498 0 -0.17 N/A cerevisiae) PRCD ENST00000592014.1 progressive rod-cone degeneration 5 3 2 1 0 0 hsa-miR-4498 0 -1.05 N/A

XPR1 ENST00000367590.4 xenotropic and polytropic retrovirus receptor 1 544 1 0 1 0 1 hsa-miR-4492 0 -0.02 N/A

POFUT2 ENST00000349485.5 protein O-fucosyltransferase 2 842 2 1 1 0 0 hsa-miR-4498 0 -0.28 N/A

ANKH ENST00000284268.6 ANKH inorganic pyrophosphate transport regulator 770 2 0 1 1 1 hsa-miR-5001-5p 0 -0.08 N/A

DZIP1L ENST00000327532.2 DAZ interacting zinc finger protein 1-like 373 1 0 0 1 0 hsa-miR-5001-5p 0 -0.1 N/A

F10 ENST00000375551.3 coagulation factor X 208 1 0 0 1 1 hsa-miR-5001-5p 0 -0.02 N/A

DCAF5 ENST00000341516.5 DDB1 and CUL4 associated factor 5 120 1 0 0 1 0 hsa-miR-5001-5p 0 -0.01 N/A

THEM4 ENST00000368814.3 thioesterase superfamily member 4 262 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

SMG9 ENST00000270066.6 SMG9 nonsense mediated mRNA decay factor 401 1 0 1 0 0 hsa-miR-4498 0 -0.27 N/A

NUP133 ENST00000261396.3 nucleoporin 133kDa 2054 1 0 1 0 0 hsa-miR-4498 0 -0.07 N/A

MAMDC4 ENST00000317446.2 MAM domain containing 4 377 2 0 0 2 0 hsa-miR-5001-5p 0 -0.12 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score TSC22D2 ENST00000361875.3 TSC22 domain family, member 2 1062 2 0 1 1 0 hsa-miR-5001-5p 0 -0.3 N/A

TCP10L ENST00000300258.3 t-complex 10-like 5 4 1 1 2 0 hsa-miR-4498 0 -0.86 N/A

METTL22 ENST00000381920.3 methyltransferase like 22 553 1 1 0 0 1 hsa-miR-5001-5p 0 -0.36 N/A

RHNO1 ENST00000489288.2 RAD9-HUS1-RAD1 interacting nuclear orphan 1 786 1 0 1 0 0 hsa-miR-4498 0 -0.2 N/A

ZNF106 ENST00000263805.4 zinc finger protein 106 406 1 0 1 0 0 hsa-miR-4498 0 -0.12 N/A

CPE ENST00000402744.4 carboxypeptidase E 282 1 0 0 1 0 hsa-miR-4498 0 -0.1 N/A

DNASE1L3 ENST00000486455.1 deoxyribonuclease I-like 3 5 4 1 2 1 1 hsa-miR-4498 0 -0.89 N/A

HAS2 ENST00000303924.4 hyaluronan synthase 2 398 1 0 0 1 0 hsa-miR-5001-5p 0 -0.08 N/A

LIPT2 ENST00000310109.4 lipoyl(octanoyl) transferase 2 (putative) 198 1 0 1 0 0 hsa-miR-4498 0 -0.11 N/A

NAP1L1 ENST00000261182.8 nucleosome assembly protein 1-like 1 9072 1 0 0 1 0 hsa-miR-4498 0 -0.05 N/A

CSE1L ENST00000262982.2 CSE1 chromosome segregation 1-like (yeast) 96 1 0 0 1 0 hsa-miR-4498 0 -0.05 N/A

NAA20 ENST00000310450.4 N(alpha)-acetyltransferase 20, NatB catalytic subunit 1586 1 0 1 0 0 hsa-miR-4498 0 -0.27 N/A

DIRC2 ENST00000261038.5 disrupted in renal carcinoma 2 1041 1 0 1 0 0 hsa-miR-5001-5p 0 -0.26 N/A carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase CHST14 ENST00000306243.5 1143 1 0 1 0 0 hsa-miR-5001-5p 0 -0.26 N/A 14 NARS ENST00000256854.5 asparaginyl-tRNA synthetase 467 1 0 1 0 1 hsa-miR-4498 0 -0.25 N/A

PIGP ENST00000360525.4 phosphatidylinositol glycan anchor biosynthesis, class P 1621 2 0 0 2 1 hsa-miR-4498 0 -0.44 N/A

NTMT1 ENST00000372481.3 N-terminal Xaa-Pro-Lys N-methyltransferase 1 1628 1 0 1 0 0 hsa-miR-4498 0 -0.09 N/A

CLEC4C ENST00000542353.1 C-type lectin domain family 4, member C 5 2 1 1 0 1 hsa-miR-4498 0 -0.7 N/A

ORMDL2 ENST00000243045.5 ORM1-like 2 (S. cerevisiae) 1649 1 1 0 0 0 hsa-miR-5001-5p 0 -0.41 N/A

USP24 ENST00000294383.6 ubiquitin specific peptidase 24 306 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

CAPZB ENST00000375142.1 capping protein (actin filament) muscle Z-line, beta 545 3 1 2 0 1 hsa-miR-5001-5p 0 -0.46 N/A

GEMIN4 ENST00000319004.5 gem (nuclear organelle) associated protein 4 339 1 0 1 0 0 hsa-miR-4498 0 -0.09 N/A

HSPA2 ENST00000394709.1 heat shock 70kDa protein 2 600 1 1 0 0 0 hsa-miR-5001-5p 0 -0.1 N/A

GTPBP8 ENST00000383677.3 GTP-binding protein 8 (putative) 326 1 0 0 1 1 hsa-miR-5001-5p 0 -0.1 N/A

BAG1 ENST00000472232.3 BCL2-associated athanogene 8934 3 2 1 0 1 hsa-miR-5001-5p 0 -0.51 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RBM25 ENST00000261973.7 RNA binding motif protein 25 1190 1 0 1 0 0 hsa-miR-4498 0 -0.23 N/A

TPD52 ENST00000379096.5 tumor protein D52 4585 1 1 0 0 0 hsa-miR-5001-5p 0 -0.26 N/A HECT, UBA and WWE domain containing 1, E3 ubiquitin HUWE1 ENST00000342160.3 741 1 0 0 1 0 hsa-miR-4498 0 -0.17 N/A protein ligase src-related kinase lacking C-terminal regulatory tyrosine and SRMS ENST00000217188.1 5 2 1 1 0 1 hsa-miR-4498 0 -0.67 N/A N-terminal myristylation sites RP11-210M15.2 ENST00000559008.1 Uncharacterized protein 5 2 1 0 1 1 hsa-miR-5001-5p 0 -0.66 N/A

EXD2 ENST00000409018.3 exonuclease 3'-5' domain containing 2 3135 1 0 0 1 0 hsa-miR-5001-5p 0 -0.07 N/A

DUSP1 ENST00000239223.3 dual specificity phosphatase 1 37211 1 0 0 1 0 hsa-miR-5001-5p 0 -0.17 N/A

ZNF607 ENST00000355202.4 zinc finger protein 607 667 1 0 1 0 1 hsa-miR-4498 0 -0.12 N/A translocase of inner mitochondrial membrane 10 homolog TIMM10 ENST00000257245.4 2518 1 0 1 0 1 hsa-miR-4498 0 -0.32 N/A (yeast) ISY1 ENST00000393292.3 ISY1 splicing factor homolog (S. cerevisiae) 897 2 0 2 0 0 hsa-miR-4498 0 -0.18 N/A

LDLRAD1 ENST00000371362.3 low density lipoprotein receptor class A domain containing 1 5 2 1 0 1 0 hsa-miR-5001-5p 0 -0.58 N/A

TROAP ENST00000257909.3 trophinin associated protein 270 1 0 1 0 0 hsa-miR-5001-5p 0 -0.09 N/A

MTG2 ENST00000370823.3 mitochondrial ribosome-associated GTPase 2 509 1 0 1 0 1 hsa-miR-4498 0 -0.1 N/A

FHL2 ENST00000409177.1 four and a half LIM domains 2 3097 3 0 1 2 0 hsa-miR-5001-5p 0 -0.36 N/A

ACOT2 ENST00000538782.1 acyl-CoA thioesterase 2 5 2 0 1 1 2 hsa-miR-5001-5p 0 -0.51 N/A

MYCBP2 ENST00000544440.2 MYC binding protein 2, E3 ubiquitin protein ligase 343 1 0 1 0 1 hsa-miR-4498 0 -0.14 N/A

ACSF2 ENST00000427954.2 acyl-CoA synthetase family member 2 1502 1 0 1 0 0 hsa-miR-4498 0 -0.2 N/A

PPTC7 ENST00000354300.3 PTC7 protein phosphatase homolog (S. cerevisiae) 817 1 0 1 0 0 hsa-miR-4498 0 -0.14 N/A

EBNA1BP2 ENST00000431635.2 EBNA1 binding protein 2 930 1 0 0 1 0 hsa-miR-5001-5p 0 -0.13 N/A

RAD50 ENST00000378823.3 RAD50 homolog (S. cerevisiae) 335 1 0 1 0 1 hsa-miR-5001-5p 0 -0.09 N/A

CTSH ENST00000220166.5 cathepsin H 1101 1 0 0 1 0 hsa-miR-5001-5p 0 -0.19 N/A

INTS7 ENST00000366994.3 integrator complex subunit 7 431 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A

YIPF4 ENST00000238831.4 Yip1 domain family, member 4 3482 1 0 1 0 0 hsa-miR-4498 0 -0.06 N/A

HTT ENST00000355072.5 huntingtin 731 1 0 1 0 2 hsa-miR-5001-5p 0 -0.02 N/A

UBE2E2 ENST00000396703.1 ubiquitin-conjugating enzyme E2E 2 794 1 0 0 1 0 hsa-miR-4498 0 -0.13 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score STK16 ENST00000409638.3 serine/threonine kinase 16 1416 1 0 1 0 1 hsa-miR-4498 0 -0.13 N/A

BBIP1 ENST00000454061.1 BBSome interacting protein 1 772 1 0 1 0 0 hsa-miR-4498 0 -0.21 N/A

TACR2 ENST00000373307.1 tachykinin receptor 2 5 2 1 0 1 0 hsa-miR-5001-5p 0 -0.4 N/A

CDK11B ENST00000407249.3 cyclin-dependent kinase 11B 5 2 0 2 0 0 hsa-miR-4498 0 -0.43 N/A

ARMC3 ENST00000409983.3 armadillo repeat containing 3 5 1 1 0 0 0 hsa-miR-5001-5p 0 -0.39 N/A

PANK2 ENST00000497424.1 pantothenate kinase 2 1244 1 0 1 0 1 hsa-miR-4498 0 -0.18 N/A

RPA1 ENST00000254719.5 replication protein A1, 70kDa 2834 2 0 1 1 1 hsa-miR-4498 0 -0.37 N/A

GPR78 ENST00000382487.4 G protein-coupled receptor 78 5 2 1 0 1 0 hsa-miR-5001-5p 0 -0.38 N/A

PDK1 ENST00000282077.3 pyruvate dehydrogenase kinase, isozyme 1 637 2 1 0 1 1 hsa-miR-5001-5p 0 -0.09 N/A

TP53TG5 ENST00000372726.3 TP53 target 5 5 1 1 0 0 0 hsa-miR-4498 0 -0.38 N/A

FAM86B1 ENST00000448228.2 family with sequence similarity 86, member B1 5 1 1 0 0 0 hsa-miR-4498 0 -0.41 N/A COX assembly mitochondrial protein 1 homolog (S. CMC1 ENST00000466830.1 1203 1 0 0 1 1 hsa-miR-5001-5p 0 -0.17 N/A cerevisiae) DEFB105B ENST00000335510.6 defensin, beta 105B 5 1 0 1 0 0 hsa-miR-4492 0 -0.39 N/A

LMAN2L ENST00000264963.4 lectin, mannose-binding 2-like 355 1 1 0 0 1 hsa-miR-5001-5p 0 -0.18 N/A minichromosome maintenance complex component 3 MCM3AP ENST00000397708.1 240 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A associated protein SLC38A10 ENST00000374759.3 solute carrier family 38, member 10 3906 1 0 1 0 0 hsa-miR-4498 0 -0.2 N/A

SUPT7L ENST00000337768.5 suppressor of Ty 7 (S. cerevisiae)-like 1145 1 0 0 1 0 hsa-miR-5001-5p 0 -0.05 N/A

DEFB105A ENST00000334773.6 defensin, beta 105A 5 1 0 1 0 0 hsa-miR-4492 0 -0.39 N/A

SLC35E2 ENST00000246421.4 solute carrier family 35, member E2 5 2 0 1 1 0 hsa-miR-4498 0 -0.41 N/A

ITIH5 ENST00000446830.2 inter-alpha-trypsin inhibitor heavy chain family, member 5 4 2 1 0 1 3 hsa-miR-4498 0 -0.24 N/A methylenetetrahydrofolate dehydrogenase (NADP+ MTHFD1L ENST00000367321.3 2336 1 0 0 1 0 hsa-miR-4498 0 -0.12 N/A dependent) 1-like TLR5 ENST00000540964.1 toll-like receptor 5 5 1 1 0 0 0 hsa-miR-4498 0 -0.31 N/A

EPHX2 ENST00000521400.1 epoxide hydrolase 2, cytoplasmic 6881 2 0 2 0 0 hsa-miR-4498 0 -0.29 N/A

MGMT ENST00000306010.7 O-6-methylguanine-DNA methyltransferase 2473 1 0 0 1 0 hsa-miR-5001-5p 0 -0.03 N/A

STAU2 ENST00000522695.1 staufen double-stranded RNA binding protein 2 306 1 0 0 1 0 hsa-miR-5001-5p 0 -0.02 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score potassium inwardly-rectifying channel, subfamily J, member KCNJ13 ENST00000409779.1 5 1 1 0 0 0 hsa-miR-4498 0 -0.32 N/A 13 GTF2H5 ENST00000607778.1 general transcription factor IIH, polypeptide 5 4166 2 1 0 1 0 hsa-miR-4498 0 -0.56 N/A

SMIM17 ENST00000598409.1 small integral membrane protein 17 5 1 1 0 0 0 hsa-miR-4498 0 -0.31 N/A

SMU1 ENST00000397149.3 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 325 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

AC004381.6 ENST00000261377.6 Putative RNA exonuclease NEF-sp 784 1 0 1 0 0 hsa-miR-4498 0 -0.33 N/A

C19orf10 ENST00000262947.3 chromosome 19 open reading frame 10 1263 1 0 0 1 0 hsa-miR-5001-5p 0 -0.2 N/A

GRM2 ENST00000395052.3 glutamate receptor, metabotropic 2 5 1 1 0 0 0 hsa-miR-4498 0 -0.33 N/A

NPSR1 ENST00000381539.3 neuropeptide S receptor 1 5 1 0 1 0 0 hsa-miR-4498 0 -0.32 N/A

OPTC ENST00000367222.2 opticin 5 1 0 1 0 0 hsa-miR-4498 0 -0.35 N/A

P2RX7 ENST00000328963.5 purinergic receptor P2X, ligand-gated ion channel, 7 5 2 0 1 1 0 hsa-miR-4498 0 -0.31 N/A N-acetylglucosamine-1-phosphate transferase, gamma GNPTG ENST00000204679.4 677 1 0 1 0 2 hsa-miR-5001-5p 0 -0.1 N/A subunit SP8 ENST00000418710.2 Sp8 transcription factor 95 1 0 0 1 1 hsa-miR-5001-5p 0 -0.08 N/A

POTED ENST00000299443.5 POTE ankyrin domain family, member D 5 3 0 2 1 2 hsa-miR-5001-5p 0 -0.32 N/A

LUC7L ENST00000337351.4 LUC7-like (S. cerevisiae) 898 1 0 1 0 0 hsa-miR-5001-5p 0 -0.07 N/A

GFAP ENST00000586793.1 glial fibrillary acidic protein 5 1 1 0 0 0 hsa-miR-4498 0 -0.27 N/A

SIL1 ENST00000394817.2 SIL1 nucleotide exchange factor 983 1 0 0 1 1 hsa-miR-5001-5p 0 -0.09 N/A

AC106017.1 ENST00000436914.1 Uncharacterized protein 5 1 0 0 1 0 hsa-miR-4498 0 -0.26 N/A NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, NDUFA9 ENST00000266544.5 1307 1 0 1 0 0 hsa-miR-5001-5p 0 -0.13 N/A 39kDa MCHR2 ENST00000281806.2 melanin-concentrating hormone receptor 2 5 1 0 1 0 0 hsa-miR-4498 0 -0.26 N/A

CCNG1 ENST00000340828.2 cyclin G1 1547 2 0 0 2 0 hsa-miR-4498 0 -0.23 N/A

TEPP ENST00000290871.5 testis, prostate and placenta expressed 5 1 0 1 0 1 hsa-miR-4498 0 -0.26 N/A

DGCR14 ENST00000252137.6 DiGeorge syndrome critical region gene 14 269 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

GIMAP6 ENST00000493969.1 GTPase, IMAP family member 6 5 1 0 1 0 1 hsa-miR-4498 0 -0.27 N/A

WISP1 ENST00000517423.1 WNT1 inducible signaling pathway protein 1 5 1 0 1 0 2 hsa-miR-4498 0 -0.25 N/A

MCMBP ENST00000360003.3 minichromosome maintenance complex binding protein 1411 1 0 1 0 1 hsa-miR-4498 0 -0.2 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score SLC27A4 ENST00000300456.4 solute carrier family 27 (fatty acid transporter), member 4 523 1 0 0 1 4 hsa-miR-4492 0 -0.01 N/A

LSM10 ENST00000315732.2 LSM10, U7 small nuclear RNA associated 1508 1 0 0 1 0 hsa-miR-4498 0 -0.1 N/A

OTC ENST00000039007.4 ornithine carbamoyltransferase 5 1 0 0 1 0 hsa-miR-5001-5p 0 -0.19 N/A

ABI2 ENST00000295851.5 abl-interactor 2 877 1 1 0 0 3 hsa-miR-4498 0 -0.07 N/A

UBASH3A ENST00000398367.1 ubiquitin associated and SH3 domain containing A 5 1 1 0 0 0 hsa-miR-4498 0 -0.19 N/A

ITGA1 ENST00000282588.6 integrin, alpha 1 400 1 0 1 0 0 hsa-miR-4498 0 -0.03 N/A

MSH5 ENST00000534153.4 mutS homolog 5 661 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

TCEAL4 ENST00000472484.1 transcription elongation factor A (SII)-like 4 937 1 0 0 1 0 hsa-miR-5001-5p 0 -0.1 N/A

TMEM72 ENST00000544540.1 transmembrane protein 72 5 1 0 0 1 0 hsa-miR-4498 0 -0.21 N/A

RCCD1 ENST00000394258.2 RCC1 domain containing 1 2863 1 0 1 0 0 hsa-miR-4498 0 -0.17 N/A 5-aminoimidazole-4-carboxamide ribonucleotide ATIC ENST00000236959.9 5791 2 0 1 1 2 hsa-miR-5001-5p 0 -0.3 N/A formyltransferase/IMP cyclohydrolase APOC3 ENST00000227667.3 apolipoprotein C-III 1689 1 0 1 0 0 hsa-miR-4498 0 -0.24 N/A polycystic kidney and hepatic disease 1 (autosomal PKHD1L1 ENST00000378402.5 8 2 0 1 1 0 hsa-miR-4498 0 -0.34 N/A recessive)-like 1 GNG11 ENST00000248564.5 guanine nucleotide binding protein (G protein), gamma 11 10881 1 0 1 0 0 hsa-miR-4498 0 -0.11 N/A

NLRP9 ENST00000332836.2 NLR family, pyrin domain containing 9 5 3 1 0 2 1 hsa-miR-5001-5p 0 -0.21 N/A

RBM48 ENST00000481551.1 RNA binding motif protein 48 220 1 0 0 1 0 hsa-miR-5001-5p 0 -0.04 N/A

MAGEB10 ENST00000356790.2 melanoma antigen family B, 10 5 3 0 0 3 0 hsa-miR-5001-5p 0 -0.19 N/A

KNCN ENST00000481882.2 kinocilin 5 1 0 1 0 0 hsa-miR-4498 0 -0.19 N/A

ORC6 ENST00000568364.2 origin recognition complex, subunit 6 855 1 0 0 1 0 hsa-miR-4492 0 -0.22 N/A

NIT1 ENST00000368007.4 nitrilase 1 437 1 0 1 0 0 hsa-miR-4498 0 -0.25 N/A

CHRND ENST00000258385.3 cholinergic receptor, nicotinic, delta (muscle) 5 1 0 0 1 1 hsa-miR-5001-5p 0 -0.22 N/A

RCN2 ENST00000394885.3 reticulocalbin 2, EF-hand calcium binding domain 4448 3 0 2 1 0 hsa-miR-4498 0 -0.34 N/A

LAX1 ENST00000442561.2 lymphocyte transmembrane adaptor 1 5 1 0 0 1 0 hsa-miR-5001-5p 0 -0.2 N/A

TMC2 ENST00000358864.1 transmembrane channel-like 2 5 3 1 1 1 0 hsa-miR-4498 0 -0.19 N/A

CYP2B6 ENST00000324071.4 cytochrome P450, family 2, subfamily B, polypeptide 6 5 1 0 0 1 0 hsa-miR-5001-5p 0 -0.21 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score UGT2B10 ENST00000265403.7 UDP glucuronosyltransferase 2 family, polypeptide B10 5 1 0 0 1 1 hsa-miR-5001-5p 0 -0.2 N/A

ITGA11 ENST00000423218.2 integrin, alpha 11 390 1 0 0 1 2 hsa-miR-5001-5p 0 -0.01 N/A

ACKR2 ENST00000442925.1 atypical chemokine receptor 2 5 1 0 1 0 0 hsa-miR-4498 0 -0.24 N/A

SLFN12L ENST00000260908.7 schlafen family member 12-like 5 2 0 2 0 0 hsa-miR-4498 0 -0.23 N/A

MB ENST00000401702.1 myoglobin 5 1 0 1 0 0 hsa-miR-4498 0 -0.17 N/A

DDX4 ENST00000505374.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 5 1 0 1 0 0 hsa-miR-4498 0 -0.13 N/A

SIGLEC5 ENST00000599649.1 5 1 0 1 0 0 hsa-miR-4498 0 -0.15 N/A

MELK ENST00000536987.1 maternal embryonic leucine zipper kinase 5978 1 0 1 0 1 hsa-miR-4498 0 -0.09 N/A

TMEM233 ENST00000426426.1 transmembrane protein 233 5 1 0 1 0 0 hsa-miR-4498 0 -0.13 N/A

JUND ENST00000252818.3 jun D proto-oncogene 13688 1 1 0 0 1 hsa-miR-4498 0 -0.28 N/A

FGF10 ENST00000264664.4 fibroblast growth factor 10 5 1 0 0 1 2 hsa-miR-4498 0 -0.13 N/A

HSPB3 ENST00000302005.1 heat shock 27kDa protein 3 5 1 0 0 1 1 hsa-miR-4498 0 -0.13 N/A

RNF126 ENST00000292363.5 ring finger protein 126 658 2 0 2 0 2 hsa-miR-5001-5p 0 -0.11 N/A

NLRP12 ENST00000324134.6 NLR family, pyrin domain containing 12 5 1 0 1 0 1 hsa-miR-4498 0 -0.14 N/A

AQP6 ENST00000315520.5 aquaporin 6, kidney specific 5 1 0 0 1 0 hsa-miR-5001-5p 0 -0.13 N/A

THAP7 ENST00000215742.4 THAP domain containing 7 769 1 0 1 0 2 hsa-miR-4498 0 -0.36 N/A

FGF3 ENST00000334134.2 fibroblast growth factor 3 5 1 0 1 0 0 hsa-miR-4498 0 -0.15 N/A

ADO ENST00000373783.1 2-aminoethanethiol (cysteamine) dioxygenase 686 1 0 0 1 0 hsa-miR-5001-5p 0 -0.11 N/A

ATP5J2-PTCD1 ENST00000413834.1 ATP5J2-PTCD1 readthrough 22 4 2 2 0 0 hsa-miR-4492 0 -0.71 N/A

ZNF737 ENST00000427401.4 zinc finger protein 737 7 1 0 0 1 0 hsa-miR-4498 0 -0.21 N/A

MCTS1 ENST00000371317.5 malignant T cell amplified sequence 1 6611 1 0 0 1 0 hsa-miR-4498 0 -0.1 N/A

PFKM ENST00000312352.7 phosphofructokinase, muscle 7010 1 0 1 0 1 hsa-miR-4498 0 -0.1 N/A

CD3D ENST00000300692.4 CD3d molecule, delta (CD3-TCR complex) 8 1 0 0 1 0 hsa-miR-5001-5p 0 -0.25 N/A

ZNF8 ENST00000608843.1 zinc finger protein 8 24 3 2 1 0 2 hsa-miR-4498 0 -0.82 N/A

GDE1 ENST00000353258.3 glycerophosphodiester phosphodiesterase 1 2741 2 1 0 1 0 hsa-miR-5001-5p 0 -0.39 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score calcium channel, voltage-dependent, N type, alpha 1B CACNA1B ENST00000277551.2 5 2 1 1 0 3 hsa-miR-4498 0 -0.14 N/A subunit NCL ENST00000322723.4 nucleolin 10100 1 0 1 0 2 hsa-miR-4498 0 -0.26 N/A

AKAP6 ENST00000557272.1 A kinase (PRKA) anchor protein 6 5 2 0 0 2 0 hsa-miR-4498 0 -0.13 N/A

NLRP6 ENST00000534750.1 NLR family, pyrin domain containing 6 5 1 0 1 0 3 hsa-miR-4498 0 -0.18 N/A

VCAN ENST00000265077.3 versican 542 1 0 0 1 0 hsa-miR-4498 0 -0.12 N/A

AQP1 ENST00000509504.1 Uncharacterized protein 5 2 0 0 2 1 hsa-miR-5001-5p 0 -0.17 N/A

TGFBI ENST00000442011.2 transforming growth factor, beta-induced, 68kDa 6307 1 0 1 0 0 hsa-miR-4498 0 -0.06 N/A

DUXA ENST00000554048.2 double homeobox A 5 1 0 0 1 0 hsa-miR-4498 0 -0.09 N/A

ZBTB20 ENST00000462705.1 zinc finger and BTB domain containing 20 5 5 1 3 1 1 hsa-miR-4492 0 -0.1 N/A sema domain, immunoglobulin domain (Ig), transmembrane SEMA4F ENST00000357877.2 32 1 1 0 0 0 hsa-miR-4498 0 -0.61 N/A domain (TM) and short cytoplasmic domain, (semaphorin) SHC (Src homology 2 domain containing) transforming SHC3 ENST00000375835.4 18 3 1 1 1 0 hsa-miR-4498 0 -0.34 N/A protein 3 FAM207A ENST00000291634.6 family with sequence similarity 207, member A 399 4 0 3 1 3 hsa-miR-4492 0 -0.07 N/A

CACNG2 ENST00000300105.6 calcium channel, voltage-dependent, gamma subunit 2 5 1 1 0 0 0 hsa-miR-4498 0 -0.09 N/A

MS4A2 ENST00000278888.3 membrane-spanning 4-domains, subfamily A, member 2 5 1 0 1 0 0 hsa-miR-4498 0 -0.1 N/A

RAB42 ENST00000373826.3 RAB42, member RAS oncogene family 11 1 0 1 0 0 hsa-miR-4492 0 -0.17 N/A

ENPP6 ENST00000296741.2 ectonucleotide pyrophosphatase/phosphodiesterase 6 5 1 0 0 1 1 hsa-miR-5001-5p 0 -0.09 N/A

FIGNL1 ENST00000356889.4 fidgetin-like 1 1075 1 0 1 0 0 hsa-miR-4498 0 -0.12 N/A

TIMD4 ENST00000274532.2 T-cell immunoglobulin and mucin domain containing 4 10 1 0 1 0 0 hsa-miR-4498 0 -0.22 N/A

ATP12A ENST00000218548.6 ATPase, H+/K+ transporting, nongastric, alpha polypeptide 8 1 0 1 0 0 hsa-miR-4498 0 -0.16 N/A

GNRHR ENST00000420975.2 gonadotropin-releasing hormone receptor 5 1 0 0 1 1 hsa-miR-4498 0 -0.08 N/A

ZNF611 ENST00000543227.1 zinc finger protein 611 7 1 1 0 0 2 hsa-miR-4498 0 -0.13 N/A translocase of inner mitochondrial membrane 23 homolog TIMM23 ENST00000260867.4 2176 1 1 0 0 0 hsa-miR-4498 0 -0.29 N/A (yeast) TUBB6 ENST00000591208.1 tubulin, beta 6 class V 5820 2 0 2 0 2 hsa-miR-4498 0 -0.44 N/A

BAZ2B ENST00000392782.1 bromodomain adjacent to zinc finger domain, 2B 25 3 0 3 0 0 hsa-miR-4498 0 -0.46 N/A

KLF6 ENST00000542957.1 Kruppel-like factor 6 4644 2 0 1 1 1 hsa-miR-4498 0 -0.24 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FBXO47 ENST00000378079.2 F-box protein 47 5 1 0 0 1 0 hsa-miR-4498 0 -0.11 N/A required for meiotic nuclear division 1 homolog (S. RMND1 ENST00000336451.3 11 1 0 0 1 0 hsa-miR-4498 0 -0.25 N/A cerevisiae) GPR174 ENST00000276077.1 G protein-coupled receptor 174 5 1 0 0 1 0 hsa-miR-4498 0 -0.09 N/A

RPL13 ENST00000393099.3 ribosomal protein L13 46038 1 0 1 0 0 hsa-miR-5001-5p 0 -0.06 N/A

BNC2 ENST00000380672.4 basonuclin 2 770 1 0 0 1 1 hsa-miR-4492 0 -0.01 N/A

HIRIP3 ENST00000564026.1 HIRA interacting protein 3 4526 1 0 0 1 0 hsa-miR-4498 0 -0.26 N/A solute carrier family 22 (organic cation transporter), member SLC22A2 ENST00000366953.3 5 1 0 1 0 0 hsa-miR-4498 0 -0.1 N/A 2 ZNF366 ENST00000318442.5 zinc finger protein 366 5 1 0 0 1 0 hsa-miR-5001-5p 0 -0.09 N/A

DCAF12L2 ENST00000538699.1 DDB1 and CUL4 associated factor 12-like 2 20 1 1 0 0 0 hsa-miR-4498 0 -0.39 N/A

PPP5C ENST00000012443.4 protein phosphatase 5, catalytic subunit 973 1* 0 0 0 1 hsa-miR-4498 0 0 N/A

ZNF540 ENST00000316433.4 zinc finger protein 540 15 1 0 0 1 0 hsa-miR-4498 0 -0.17 N/A

COLEC10 ENST00000332843.2 collectin sub-family member 10 (C-type lectin) 5 1 0 0 1 1 hsa-miR-4498 0 -0.04 N/A

HINT1 ENST00000304043.5 histidine triad nucleotide binding protein 1 15834 1 0 0 1 0 hsa-miR-4492 0 -0.12 N/A

TG ENST00000519543.1 thyroglobulin 5 2 1 1 0 2 hsa-miR-4492 0 -0.05 N/A

FAM163B ENST00000496132.1 family with sequence similarity 163, member B 5 1 0 1 0 3 hsa-miR-4498 0 -0.04 N/A

ZNF619 ENST00000447116.2 zinc finger protein 619 17 1 0 1 0 0 hsa-miR-4492 0 -0.1 N/A ATP-binding cassette, sub-family B (MDR/TAP), member ABCB11 ENST00000263817.6 5 1 0 1 0 1 hsa-miR-4498 0 -0.05 N/A 11 KLHL31 ENST00000370905.3 kelch-like family member 31 16 1 1 0 0 1 hsa-miR-4492 0 -0.15 N/A

AKAP1 ENST00000337714.3 A kinase (PRKA) anchor protein 1 843 1 0 0 1 0 hsa-miR-5001-5p 0 -0.04 N/A

SNAP25 ENST00000254976.2 synaptosomal-associated protein, 25kDa 54 2 0 2 0 0 hsa-miR-4498 0 -0.42 N/A

ZNF626 ENST00000291750.6 zinc finger protein 626 24 1 0 1 0 0 hsa-miR-4492 0 -0.15 N/A

MYH9 ENST00000216181.5 myosin, heavy chain 9, non-muscle 1317 1 0 1 0 1 hsa-miR-4498 0 -0.1 N/A

PDE9A ENST00000335512.4 phosphodiesterase 9A 1551 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

EPN1 ENST00000270460.6 epsin 1 5464 1 0 1 0 0 hsa-miR-4498 0 -0.12 N/A

LIPG ENST00000261292.4 lipase, endothelial 40 2 0 0 2 0 hsa-miR-5001-5p 0 -0.27 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score KCNK15 ENST00000372861.3 potassium channel, subfamily K, member 15 23 3 0 1 2 1 hsa-miR-4498 0 -0.33 N/A

RTCB ENST00000451746.2 RNA 2',3'-cyclic phosphate and 5'-OH ligase 9513 1 0 1 0 1 hsa-miR-4492 0 -0.14 N/A

MYOM2 ENST00000262113.4 myomesin 2 9 2 0 1 1 0 hsa-miR-4498 0 -0.06 N/A

PCK1 ENST00000319441.4 phosphoenolpyruvate carboxykinase 1 (soluble) 5 1 0 0 1 0 hsa-miR-4498 0 -0.03 N/A

STARD3NL ENST00000009041.7 STARD3 N-terminal like 1911 2 0 0 2 2 hsa-miR-4498 0 -0.05 N/A

WDR33 ENST00000322313.4 WD repeat domain 33 537 1 0 0 1 1 hsa-miR-4492 0 -0.01 N/A

TRNP1 ENST00000522111.2 TMF1-regulated nuclear protein 1 4046 1 0 1 0 0 hsa-miR-4498 0 -0.08 N/A

TXK ENST00000264316.4 TXK tyrosine kinase 7 1 0 1 0 0 hsa-miR-4498 0 -0.1 N/A

LRRC34 ENST00000446859.1 leucine rich repeat containing 34 48 1 1 0 0 0 hsa-miR-4498 0 -0.31 N/A

ALDOA ENST00000569798.1 aldolase A, fructose-bisphosphate 21644 1 1 0 0 0 hsa-miR-5001-5p 0 -0.26 N/A

IL9R ENST00000424344.3 interleukin 9 receptor 5 1 0 1 0 0 hsa-miR-4498 0 -0.07 N/A calcium channel, voltage-dependent, L type, alpha 1C CACNA1C ENST00000399655.1 69 3 0 2 1 2 hsa-miR-4492 0 -0.57 N/A subunit COMMD6 ENST00000406936.3 COMM domain containing 6 3151 1 0 0 1 0 hsa-miR-4498 0 -0.06 N/A

BMP10 ENST00000295379.1 bone morphogenetic protein 10 5 2 0 1 1 2 hsa-miR-4492 0 -0.03 N/A

SOD2 ENST00000538183.2 superoxide dismutase 2, mitochondrial 993 1 0 0 1 1 hsa-miR-4492 0 -0.01 N/A

SHMT1 ENST00000316694.3 serine hydroxymethyltransferase 1 (soluble) 3432 1 0 1 0 3 hsa-miR-4498 0 -0.2 N/A

APEX1 ENST00000557054.1 APEX nuclease (multifunctional DNA repair enzyme) 1 15798 1 1 0 0 0 hsa-miR-4492 0 -0.58 N/A

SCML4 ENST00000369022.2 sex comb on midleg-like 4 (Drosophila) 10 1 0 0 1 2 hsa-miR-5001-5p 0 -0.06 N/A

KY ENST00000508956.1 kyphoscoliosis peptidase 5 1 0 0 1 3 hsa-miR-5001-5p 0 -0.03 N/A

SH3TC2 ENST00000502274.1 SH3 domain and tetratricopeptide repeats 2 31 2 1 0 1 2 hsa-miR-5001-5p 0 -0.23 N/A

YAE1D1 ENST00000223273.2 Yae1 domain containing 1 49 3 0 0 3 2 hsa-miR-4498 0 -0.41 N/A potassium inwardly-rectifying channel, subfamily J, member KCNJ3 ENST00000295101.2 21 1 0 0 1 0 hsa-miR-4492 0 -0.11 N/A 3 CDR1 ENST00000370532.2 cerebellar degeneration-related protein 1, 34kDa 5 1 1 0 0 0 hsa-miR-4492 0 -0.03 N/A

PNPLA2 ENST00000336615.4 patatin-like phospholipase domain containing 2 6586 1 0 0 1 0 hsa-miR-4492 0 -0.12 N/A

ABHD15 ENST00000307201.4 abhydrolase domain containing 15 240 1 1 0 0 2 hsa-miR-4492 0 -0.13 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score RASAL2 ENST00000448150.3 RAS protein activator like 2 950 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A solute carrier family 29 (equilibrative nucleoside SLC29A1 ENST00000393844.1 678 2 0 2 0 1 hsa-miR-4492 0 -0.11 N/A transporter), member 1 ZNF140 ENST00000355557.2 zinc finger protein 140 137 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

SC5D ENST00000264027.4 sterol-C5-desaturase 1299 2 0 2 0 1 hsa-miR-4492 0 -0.11 N/A

CNTN4 ENST00000427331.1 contactin 4 191 1 0 1 0 0 hsa-miR-4492 0 -0.03 N/A

WDR13 ENST00000218056.5 WD repeat domain 13 1128 3 0 3 0 0 hsa-miR-4492 0 -0.23 N/A serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, SERPINA3 ENST00000393080.4 104 2 0 1 1 1 hsa-miR-4492 0 -0.03 N/A antitrypsin), member 3 CIRH1A ENST00000314423.7 cirrhosis, autosomal recessive 1A (cirhin) 1015 3 2 1 0 0 hsa-miR-4492 0 -0.3 N/A

ANGPTL3 ENST00000371129.3 angiopoietin-like 3 59 1 0 1 0 0 hsa-miR-4492 0 -0.04 N/A

HSD11B1 ENST00000367028.2 hydroxysteroid (11-beta) dehydrogenase 1 61 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

FAM20A ENST00000592554.1 family with sequence similarity 20, member A 198 1 0 0 1 0 hsa-miR-4492 0 -0.05 N/A

PCNXL2 ENST00000258229.9 pecanex-like 2 (Drosophila) 49 1 1 0 0 1 hsa-miR-4492 0 -0.03 N/A

KIAA1715 ENST00000272748.4 KIAA1715 858 1 1 0 0 0 hsa-miR-4492 0 -0.11 N/A

N6AMT1 ENST00000303775.5 N-6 adenine-specific DNA methyltransferase 1 (putative) 93 1 1 0 0 0 hsa-miR-4492 0 -0.24 N/A

GPC5 ENST00000377067.3 glypican 5 65 1 1 0 0 1 hsa-miR-4492 0 -0.05 N/A

MEF2C ENST00000340208.5 myocyte enhancer factor 2C 70 1 0 1 0 0 hsa-miR-4492 0 -0.12 N/A leukocyte immunoglobulin-like receptor, subfamily B (with LILRB2 ENST00000391746.1 5 1 0 0 1 0 hsa-miR-4492 0 -0.2 N/A TM and ITIM domains), member 2 SOX17 ENST00000297316.4 SRY (sex determining region Y)-box 17 65 2 1 0 1 1 hsa-miR-4492 0 -0.17 N/A spectrin repeat containing, nuclear envelope family member SYNE4 ENST00000340477.5 357 1 0 0 1 0 hsa-miR-4492 0 -0.18 N/A 4 SPATA6L ENST00000381890.5 spermatogenesis associated 6-like 14 1 0 1 0 0 hsa-miR-4492 0 -0.17 N/A

RSPO3 ENST00000356698.4 R-spondin 3 118 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

DDRGK1 ENST00000354488.3 DDRGK domain containing 1 3324 1 0 1 0 1 hsa-miR-4492 0 -0.06 N/A

SIRT5 ENST00000606117.1 sirtuin 5 72 1 0 1 0 1 hsa-miR-4492 0 -0.07 N/A

FUS ENST00000254108.7 fused in sarcoma 30612 1 1 0 0 1 hsa-miR-4492 0 -0.03 N/A

BAIAP2 ENST00000435091.3 BAI1-associated protein 2 53 1 0 1 0 2 hsa-miR-4492 0 -0.08 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PRMT7 ENST00000339507.5 protein arginine methyltransferase 7 6277 1 0 1 0 7 hsa-miR-4492 0 -0.02 N/A

CD63 ENST00000548898.1 CD63 molecule 7483 1 0 1 0 0 hsa-miR-4492 0 -0.14 N/A

MAG ENST00000392213.3 myelin associated glycoprotein 22 1 0 1 0 1 hsa-miR-4492 0 -0.03 N/A

VNN3 ENST00000207771.3 vanin 3 5 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

MLIP ENST00000274897.5 muscular LMNA-interacting protein 8 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

CACUL1 ENST00000369151.3 CDK2-associated, cullin domain 1 213 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

ZNF277 ENST00000361822.3 zinc finger protein 277 286 2 0 2 0 1 hsa-miR-4492 0 -0.15 N/A

HMGCS1 ENST00000325110.6 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 3730 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A translocase of inner mitochondrial membrane 50 homolog TIMM50 ENST00000599794.1 2210 1 0 0 1 1 hsa-miR-4492 0 -0.23 N/A (S. cerevisiae) NSL1 ENST00000422588.2 NSL1, MIS12 kinetochore complex component 180 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

CRHR2 ENST00000506074.2 corticotropin releasing hormone receptor 2 5 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

TMEM106C ENST00000429772.2 transmembrane protein 106C 27951 1 0 1 0 1 hsa-miR-4492 0 -0.02 N/A

COMMD9 ENST00000263401.5 COMM domain containing 9 1146 1 0 1 0 0 hsa-miR-4492 0 -0.09 N/A

STRADA ENST00000375840.4 STE20-related kinase adaptor alpha 366 2 0 1 1 1 hsa-miR-4492 0 -0.16 N/A

RARRES3 ENST00000255688.3 retinoic acid receptor responder (tazarotene induced) 3 60 1 0 1 0 0 hsa-miR-4492 0 -0.23 N/A

MRPL19 ENST00000393909.2 mitochondrial ribosomal protein L19 816 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

TNFAIP8L3 ENST00000327536.5 tumor necrosis factor, alpha-induced protein 8-like 3 259 2 0 0 2 1 hsa-miR-4492 0 -0.12 N/A

SURF6 ENST00000372022.4 surfeit 6 175 1 0 1 0 1 hsa-miR-4492 0 -0.13 N/A

NUP93 ENST00000542526.1 nucleoporin 93kDa 1604 2 0 1 1 0 hsa-miR-4492 0 -0.07 N/A

NICN1 ENST00000273598.3 nicolin 1 244 1 0 0 1 1 hsa-miR-4492 0 -0.05 N/A ectonucleotide pyrophosphatase/phosphodiesterase 5 ENPP5 ENST00000371383.2 15 3 0 0 3 0 hsa-miR-4492 0 -0.03 N/A (putative) TROVE2 ENST00000367444.3 TROVE domain family, member 2 272 2 0 1 1 0 hsa-miR-4492 0 -0.13 N/A

PDXDC1 ENST00000396410.4 pyridoxal-dependent decarboxylase domain containing 1 6417 1 0 1 0 0 hsa-miR-4492 0 -0.03 N/A

LRRC40 ENST00000370952.3 leucine rich repeat containing 40 88 1 0 0 1 0 hsa-miR-4492 0 -0.04 N/A

TLR3 ENST00000296795.3 toll-like receptor 3 5 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score PLIN5 ENST00000381848.3 perilipin 5 125 1 1 0 0 0 hsa-miR-4492 0 -0.26 N/A

PDLIM3 ENST00000284770.5 PDZ and LIM domain 3 58 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

LAMA4 ENST00000230538.7 laminin, alpha 4 605 1 1 0 0 0 hsa-miR-4492 0 -0.06 N/A

C11orf54 ENST00000528288.1 chromosome 11 open reading frame 54 47 1 0 0 1 0 hsa-miR-4492 0 -0.13 N/A

LARP4B ENST00000316157.3 La ribonucleoprotein domain family, member 4B 705 1 0 0 1 0 hsa-miR-4492 0 -0.07 N/A

MYBPC1 ENST00000392934.3 myosin binding protein C, slow type 5 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

TGFBR2 ENST00000359013.4 transforming growth factor, beta receptor II (70/80kDa) 2168 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

TMEM33 ENST00000504986.1 transmembrane protein 33 1470 2 0 1 1 1 hsa-miR-4492 0 -0.09 N/A

DSE ENST00000452085.3 dermatan sulfate epimerase 975 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A adaptor-related protein complex 1 associated regulatory AP1AR ENST00000274000.5 89 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A protein RRAGC ENST00000373001.3 Ras-related GTP binding C 1062 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

C1QTNF8 ENST00000328449.5 C1q and tumor necrosis factor related protein 8 5 2 0 2 0 2 hsa-miR-4492 0 -0.12 N/A

PRDX2 ENST00000301522.2 peroxiredoxin 2 7500 1 1 0 0 0 hsa-miR-4492 0 -0.26 N/A

SEC23IP ENST00000369075.3 SEC23 interacting protein 765 1 0 1 0 0 hsa-miR-4492 0 -0.02 N/A

PON1 ENST00000222381.3 paraoxonase 1 64 1 0 0 1 0 hsa-miR-4492 0 -0.06 N/A

C18orf32 ENST00000579820.1 chromosome 18 open reading frame 32 733 1 0 0 1 0 hsa-miR-4492 0 -0.14 N/A

PCDHB15 ENST00000231173.3 protocadherin beta 15 33 1 0 1 0 0 hsa-miR-4492 0 -0.04 N/A

GUCY1A3 ENST00000296518.7 guanylate cyclase 1, soluble, alpha 3 42 1 0 0 1 0 hsa-miR-4492 0 -0.01 N/A

PPAP2B ENST00000371250.3 phosphatidic acid phosphatase type 2B 81 2 0 1 1 1 hsa-miR-4492 0 -0.12 N/A

PHLDA1 ENST00000602540.1 pleckstrin homology-like domain, family A, member 1 3907 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

SCRIB ENST00000356994.2 scribbled planar cell polarity protein 16 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

LRRN2 ENST00000367175.1 leucine rich repeat neuronal 2 12 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A v-maf avian musculoaponeurotic fibrosarcoma oncogene MAFA ENST00000333480.2 7 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A homolog A BAX ENST00000293288.8 BCL2-associated X protein 3455 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

SMO ENST00000249373.3 smoothened, frizzled family receptor 142 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A Total Total 8mer 7mer-m8 7mer-A1 6mer Cumulative weighted Aggregate Target gene Representative transcript Gene name 3P-seq tags + 5 Representative miRNA context++ sites sites sites sites sites context++ score PCT score FAM120B ENST00000476287.1 family with sequence similarity 120B 764 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

DOC2A ENST00000350119.4 double C2-like domains, alpha 10 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

GRIP1 ENST00000398016.3 glutamate receptor interacting protein 1 28 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

CARKD ENST00000309957.2 carbohydrate kinase domain containing 514 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

RP11-867G23.8 ENST00000531602.1 Uncharacterized protein 1851 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

ZNF211 ENST00000347302.3 zinc finger protein 211 420 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

METTL12 ENST00000532971.1 methyltransferase like 12 219 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

GPX1 ENST00000419349.1 glutathione peroxidase 1 122 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

AP000867.1 ENST00000343767.3 5 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

RP11-268J15.5 ENST00000373137.2 141 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

SIAH3 ENST00000400405.2 siah E3 ubiquitin protein ligase family member 3 5 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

C4orf40 ENST00000344526.5 chromosome 4 open reading frame 40 5 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

WWC3 ENST00000380861.4 WWC family member 3 11 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

FAM46C ENST00000369448.3 family with sequence similarity 46, member C 74 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

C2 ENST00000299367.5 complement component 2 52 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

CYP46A1 ENST00000261835.3 cytochrome P450, family 46, subfamily A, polypeptide 1 16 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

HSPA1B ENST00000375650.3 heat shock 70kDa protein 1B 488 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A

RPL12 ENST00000361436.5 ribosomal protein L12 30 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

GRIN2D ENST00000263269.3 glutamate receptor, ionotropic, N-methyl D-aspartate 2D 5 1* 0 0 0 0 hsa-miR-762 N/A N/A N/A

PLIN1 ENST00000300055.5 perilipin 1 10 1* 0 0 0 0 hsa-miR-5001-5p N/A N/A N/A

ZNF225 ENST00000592780.1 zinc finger protein 225 100 1* 0 0 0 0 hsa-miR-4498 N/A N/A N/A