Death, Dying, and Neglected Gardens: Exploring the Ethical Consequences of Immortality
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The Lived Experience of Being a Hundred Years and Over
The lived experience of being a hundred years and over By Ashwina Naiker-Ratan A thesis submitted to Victoria University of Wellington in fulfilment of the requirements for the Degree of Master of Health Research Victoria University of Wellington 2016 ABSTRACT The twentieth century has seen a decline in mortality after the age of eighty and an increase in survival rates of the oldest of the old. Centenarians (people over a hundred years of age) are the fastest growing group of this population in developed countries; however qualitative research on the oldest of the old is limited. The primary aim of this study was to gain an understanding of the essence of lived experiences and meanings of extended longevity as perceived by centenarians. It also aimed to explore the role of lifestyle characteristics, family, social, health and cultural factors in regards to their prolonged existence. The research was conducted with ten centenarians aged between 100 and 106 years living in the Lower North Island namely Wairarapa, Kapiti and Wellington of Aotearoa New Zealand. Biographical Narrative Interpretive Method of inquiry was used to guide the data collection through face-to-face interviews using unstructured open ended questions. Colazzi’s phenomenological framework was employed for data analysis. There were common patterns throughout the life stories related by the centenarians and resilience and acceptance of life was notable. The centenarians spoke nonchalantly about their experience of turning a hundred, describing their birthday as; “Just another day.” Positive personalities and resilient nature were prominent features of the participants who all expressed a sense of acceptance and satisfaction with life and contentment with living in the present. -
Eternity and Immortality in Spinoza's Ethics
Midwest Studies in Philosophy, XXVI (2002) Eternity and Immortality in Spinoza’s Ethics STEVEN NADLER I Descartes famously prided himself on the felicitous consequences of his philoso- phy for religion. In particular, he believed that by so separating the mind from the corruptible body, his radical substance dualism offered the best possible defense of and explanation for the immortality of the soul. “Our natural knowledge tells us that the mind is distinct from the body, and that it is a substance...And this entitles us to conclude that the mind, insofar as it can be known by natural phi- losophy, is immortal.”1 Though he cannot with certainty rule out the possibility that God has miraculously endowed the soul with “such a nature that its duration will come to an end simultaneously with the end of the body,” nonetheless, because the soul (unlike the human body, which is merely a collection of material parts) is a substance in its own right, and is not subject to the kind of decomposition to which the body is subject, it is by its nature immortal. When the body dies, the soul—which was only temporarily united with it—is to enjoy a separate existence. By contrast, Spinoza’s views on the immortality of the soul—like his views on many issues—are, at least in the eyes of most readers, notoriously difficult to fathom. One prominent scholar, in what seems to be a cry of frustration after having wrestled with the relevant propositions in Part Five of Ethics,claims that this part of the work is an “unmitigated and seemingly unmotivated disaster.. -
Therapeutic Targeting of Replicative Immortality
Seminars in Cancer Biology 35 (2015) S104–S128 Contents lists available at ScienceDirect Seminars in Cancer Biology jo urnal homepage: www.elsevier.com/locate/semcancer Review Therapeutic targeting of replicative immortality a,∗ b c d e Paul Yaswen , Karen L. MacKenzie , W. Nicol Keith , Patricia Hentosh , Francis Rodier , f g h i c Jiyue Zhu , Gary L. Firestone , Ander Matheu , Amancio Carnero , Alan Bilsland , j k,1 k,1 l,1 Tabetha Sundin , Kanya Honoki , Hiromasa Fujii , Alexandros G. Georgakilas , m,1 n,o,1 p,1 q,1 Amedeo Amedei , Amr Amin , Bill Helferich , Chandra S. Boosani , r,1 s,1 t,1 u,1 Gunjan Guha , Maria Rosa Ciriolo , Sophie Chen , Sulma I. Mohammed , v,1 r,1 w,1 m,1 Asfar S. Azmi , Dipita Bhakta , Dorota Halicka , Elena Niccolai , s,1 n,o,1 x,1 p,1 Katia Aquilano , S. Salman Ashraf , Somaira Nowsheen , Xujuan Yang a Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA, United States b Children’s Cancer Institute Australia, Kensington, New South Wales, Australia c University of Glasgow, Glasgow, United Kingdom d Old Dominion University, Norfolk, VA, United States e Universit´e de Montr´eal, Montr´eal, QC, Canada f Washington State University College of Pharmacy, Pullman, WA, United States g University of California Berkeley, Berkeley, CA, United States h Biodonostia Institute, Gipuzkoa, Spain i Instituto de Biomedicina de Sevilla, HUVR, Consejo Superior de Investigaciones Cientificas, Universdad de Sevilla, Seville, Spain j Sentara Healthcare, Norfolk, VA, United States k Nara Medical University, Kashihara, -
Immortality of the Soul (Plat Ōn) and Bodily Resurrection (Paul) — Any Rapprochement?
IMMORTALITY OF THE SOUL (PLAT ŌN) AND BODILY RESURRECTION (PAUL) — ANY RAPPROCHEMENT? ChrYs C. Caragounis [email protected] ABSTRACT It is a usual assumption among NeW Testament scholars that in his discussion of the resurrec - tion of the dead, Paul holds to the JeWish VieW of the resurrection of the bodY, not to the Hellenic (Platonic) VieW of the immortalitY of the soul. As this question impinges on the question of anthropologY, it is further stated that according to the Hellenic VieW man has a bodY — Which, moreoVer is conceiVed as a tomb of the soul (Orphics) — Whereas accor - ding to the JeWish VieW man is a bodY. A careful inVestigation of the Hellenic and OT-JeWish eVidence shoWs that it is a metho - dological miss to confuse VieWs in Hom ēros and the Orphics With later VieWs in Sokrates and Plat ōn. MoreoVer there neVer Was a “JeWish VieW” of the resurrection. There Were fiVe/siX VieWs. The resurrection of the bodY Was a minoritY VieW. The Pauline teXts shoW that Paul speaks of the resurrection of the dead but neVer of the resurrection of the bodY as Well as that man has a bodY. It is thus intriguing to compare Paul’s VieW of resurrection With Plat ōn’s VieW of the immortalitY of the soul and see hoW far apart theY are from one another. KEY WORDS : First Corinthians, Resurrection (of the bodY), ImmortalitY of the soul. 3 2 1 5 - 1. INTRODUCTION 3 2 . P P , Ernest Best prefaces his discussion of 1 Th 5:23 in his commentarY With 6 1 0 the remark that “To the Greek for Whom the bodY Was the tomb or prison of the 2 ; 1 7 immortal soul its ultimate fate Was unimportant” . -
The Makropulos Case: Reflections on the Tedium of Immortality
The Makropulos case: reflections on the tedium of immortality Author: Bernard Williams Source: Problems of the Self, Cambridge: Cambridge University Press, 1973. This essay started life as a lecture in a series ‘on the immortality of the soul or kindred spiritual subject’.1 My kindred spiritual subject is, one might say, the mortality of the soul. Those among previous lecturers who were philosophers tended, I think, to discuss the question whether we are immortal; that is not my subject, but rather what a good thing it is that we are not. Immortality, or a state without death, would be meaningless, I shall suggest; so, in a sense, death gives the meaning to life. That does not mean that we should not fear death (whatever force that injunction might be taken to have, anyway). Indeed, there are several very different ways in which it could be true at once that death gave the meaning to life and that death was, other things being equal, something to be feared. Some existentialists, for instance, seem to have said that death was what gave meaning to life, if anything did, just because it was the fear of death that gave meaning to life; I shall not follow them. I shall rather pursue the idea that from facts about human desire and happiness and what a human life is, it follows both that immortality would be, where conceivable at all, intolerable, and that (other things being equal) death is reasonably regarded as an evil. Considering whether death can reasonably be regarded as an evil is in fact as near as I shall get to considering whether it should be feared: they are not quite the same question. -
Forkhead Transcription Factors and Ageing
Oncogene (2008) 27, 2351–2363 & 2008 Nature Publishing Group All rights reserved 0950-9232/08 $30.00 www.nature.com/onc REVIEW Forkhead transcription factors and ageing L Partridge1 and JC Bru¨ ning2 1Institute of Healthy Ageing, GEE, London, UK; 2Department of Mouse Genetics and Metabolism, Institute for Genetics University of Cologne, Cologne, Germany Mutations in single genes and environmental interventions Forkhead transcription factors are turning out to play can extend healthy lifespan in laboratory model organi- a key role in invertebrate models ofextension ofhealthy sms. Some of the mechanisms involved show evolutionary lifespan by single-gene mutations, and evidence is conservation, opening the way to using simpler inverte- mounting for their importance in mammals. Forkheads brates to understand human ageing. Forkhead transcrip- can also play a role in extension oflifespanby dietary tion factors have been found to play a key role in lifespan restriction, an environmental intervention that also extension by alterations in the insulin/IGF pathway and extends lifespan in diverse organisms (Kennedy et al., by dietary restriction. Interventions that extend lifespan 2007). Here, we discuss these findings and their have also been found to delay or ameliorate the impact of implications. The forkhead family of transcription ageing-related pathology and disease, including cancer. factors is characterized by a type of DNA-binding Understanding the mode of action of forkheads in this domain known as the forkhead box (FOX) (Weigel and context will illuminate the mechanisms by which ageing Jackle, 1990). They are also called winged helix acts as a risk factor for ageing-related disease, and could transcription factors because of the crystal structure lead to the development of a broad-spectrum, preventative ofthe FOX, ofwhich the forkheadscontain a medicine for the diseases of ageing. -
World Population Ageing 2019
World Population Ageing 2019 Highlights ST/ESA/SER.A/430 Department of Economic and Social Affairs Population Division World Population Ageing 2019 Highlights United Nations New York, 2019 The Department of Economic and Social Affairs of the United Nations Secretariat is a vital interface between global policies in the economic, social and environmental spheres and national action. The Department works in three main interlinked areas: (i) it compiles, generates and analyses a wide range of economic, social and environmental data and information on which States Members of the United Nations draw to review common problems and take stock of policy options; (ii) it facilitates the negotiations of Member States in many intergovernmental bodies on joint courses of action to address ongoing or emerging global challenges; and (iii) it advises interested Governments on the ways and means of translating policy frameworks developed in United Nations conferences and summits into programmes at the country level and, through technical assistance, helps build national capacities. The Population Division of the Department of Economic and Social Affairs provides the international community with timely and accessible population data and analysis of population trends and development outcomes for all countries and areas of the world. To this end, the Division undertakes regular studies of population size and characteristics and of all three components of population change (fertility, mortality and migration). Founded in 1946, the Population Division provides substantive support on population and development issues to the United Nations General Assembly, the Economic and Social Council and the Commission on Population and Development. It also leads or participates in various interagency coordination mechanisms of the United Nations system. -
“Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014
1 “Is Cryonics an Ethical Means of Life Extension?” Rebekah Cron University of Exeter 2014 2 “We all know we must die. But that, say the immortalists, is no longer true… Science has progressed so far that we are morally bound to seek solutions, just as we would be morally bound to prevent a real tsunami if we knew how” - Bryan Appleyard 1 “The moral argument for cryonics is that it's wrong to discontinue care of an unconscious person when they can still be rescued. This is why people who fall unconscious are taken to hospital by ambulance, why they will be maintained for weeks in intensive care if necessary, and why they will still be cared for even if they don't fully awaken after that. It is a moral imperative to care for unconscious people as long as there remains reasonable hope for recovery.” - ALCOR 2 “How many cryonicists does it take to screw in a light bulb? …None – they just sit in the dark and wait for the technology to improve” 3 - Sterling Blake 1 Appleyard 2008. Page 22-23 2 Alcor.org: ‘Frequently Asked Questions’ 2014 3 Blake 1996. Page 72 3 Introduction Biologists have known for some time that certain organisms can survive for sustained time periods in what is essentially a death"like state. The North American Wood Frog, for example, shuts down its entire body system in winter; its heart stops beating and its whole body is frozen, until summer returns; at which point it thaws and ‘comes back to life’ 4. -
Dissecting Aging and Senescence—Current Concepts and Open Lessons
cells Review Dissecting Aging and Senescence—Current Concepts and Open Lessons 1,2, , 1,2, 1 1,2 Christian Schmeer * y , Alexandra Kretz y, Diane Wengerodt , Milan Stojiljkovic and Otto W. Witte 1,2 1 Hans-Berger Department of Neurology, Jena University Hospital, 07747 Jena, Thuringia, Germany; [email protected] (A.K.); [email protected] (D.W.); [email protected] (M.S.); [email protected] (O.W.W.) 2 Jena Center for Healthy Ageing, Jena University Hospital, 07747 Jena, Thuringia, Germany * Correspondence: [email protected] These authors have contributed equally. y Received: 2 October 2019; Accepted: 13 November 2019; Published: 15 November 2019 Abstract: In contrast to the programmed nature of development, it is still a matter of debate whether aging is an adaptive and regulated process, or merely a consequence arising from a stochastic accumulation of harmful events that culminate in a global state of reduced fitness, risk for disease acquisition, and death. Similarly unanswered are the questions of whether aging is reversible and can be turned into rejuvenation as well as how aging is distinguishable from and influenced by cellular senescence. With the discovery of beneficial aspects of cellular senescence and evidence of senescence being not limited to replicative cellular states, a redefinition of our comprehension of aging and senescence appears scientifically overdue. Here, we provide a factor-based comparison of current knowledge on aging and senescence, which we converge on four suggested concepts, thereby implementing the newly emerging cellular and molecular aspects of geroconversion and amitosenescence, and the signatures of a genetic state termed genosenium. -
Mechanisms and Rejuvenation Strategies for Aged Hematopoietic
Li et al. Journal of Hematology & Oncology (2020) 13:31 https://doi.org/10.1186/s13045-020-00864-8 REVIEW Open Access Mechanisms and rejuvenation strategies for aged hematopoietic stem cells Xia Li1,2,3†, Xiangjun Zeng1,2,3†, Yulin Xu1,2,3, Binsheng Wang1,2,3, Yanmin Zhao1,2,3, Xiaoyu Lai1,2,3, Pengxu Qian1,2,3 and He Huang1,2,3* Abstract Hematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability, impaired homing, myeloid-biased differentiation, and other defects in hematopoietic reconstitution function, is a hot topic in stem cell research. Although the number of HSCs increases with age in both mice and humans, the increase cannot compensate for the defects of aged HSCs. Many studies have been performed from various perspectives to illustrate the potential mechanisms of HSC aging; however, the detailed molecular mechanisms remain unclear, blocking further exploration of aged HSC rejuvenation. To determine how aged HSC defects occur, we provide an overview of differences in the hallmarks, signaling pathways, and epigenetics of young and aged HSCs as well as of the bone marrow niche wherein HSCs reside. Notably, we summarize the very recent studies which dissect HSC aging at the single-cell level. Furthermore, we review the promising strategies for rejuvenating aged HSC functions. Considering that the incidence of many hematological malignancies is strongly associated with age, our HSC aging review delineates the association between functional changes and molecular mechanisms and may have significant clinical relevance. Keywords: Hematopoietic stem cells, Aging, Single-cell sequencing, Epigenetics, Rejuvenation Background in the clinic, donor age is carefully considered in HSC A key step in hematopoietic stem cell (HSC) aging re- transplantation, and young donors result in better sur- search was achieved in 1996, revealing that HSCs from vival after HSC transplantation [2–4]. -
Chapter 9. Myths of Life Extension
Chapter 9. Myths of Life Extension Ever since humans became fully aware that they will get old and die, individuals must have wondered about the possibility of extending longevity, or achieving immortality on earth. This has resulted in innumerable myths relating to supposed examples of life-extension, one of the most notable being the 969 year lifespan of Methuselah, as recorded in the Bible. Christian fundamentalists are liable to say that in those days people lived much longer than they do today! These are many other claims, and far too many to list here. The Guiness Book of Records has stated that maximum lifespans of people and animals are some of the hardest records to document. Some of the claims of human longevity have occurred in the 20th century, and as in some cases they were initially accepted by scientists, and they provide good examples of how people are deceived. Many people living in the Caucasus region of the ex-Soviet Union claimed their ages were over 120 years, or even 160 years. There was even a touring troup of centenarian dancers, so it is not surprising the claims received wide publicity, and also wide acceptance. The oldest people were usually males which is intrinsically unlikely as human females live longer that males. Careful scrutiny of these cases, particularly by the gerontologist Zhores Medvedev, has shown that none are backed up by reliable records. In some cases, individuals took on the identity of their father, in others they exaggerated their age to escape military conscription, or they simply added on years, because the societies in which they lived respected the wisdom and experience of very old people. -
A Symbolic Analysis of Ritualistic Crime: the Forensics of Sacrifice 1
RBSE 8(24): 524-621, Dez2009 ISSN 1676-8965 ARTIGO A Symbolic Analysis of Ritualistic Crime: The Forensics of Sacrifice 1 Dawn Perlmutter Resumo: O assassinato ritual inclui uma grande variedade de atos sagrados e temporais cometidos por grupos e por indivíduos e é atribuído o mais frequentemente aos praticantes de ideologias ocultas tais como o Satanismo, o Palo Mayombe, a Santeria e outras tradições mágicas, ou aos assassinos em série e aos sadistas sexuais que assassinam ritualmente as suas vítimas. Devido a muitas controvérsias legais, práticas e éticas o estudo da violência religiosa contemporânea está em sua infância. Não houve nenhum estudo empírico sério dos crimes ou das classificações ritualísticas que distingam adequadamente entre os homicídios rituais cometidos para sagrado versus motivações temporais. Este artigo é o resultado de minha pesquisa na fenomenologia da adoração da imagem, de rituais contemporâneos do sangue, e da violência sagrada. Reflete meu esforço contínuo para proteger as liberdades religiosas de membros de religiões alternativas ao ajudar profissionais da lei de lei na investigação de crimes ritualísticos. Unitermos: Sacrifício; Violência Ritual; Análise Simbólica. Abstract : Ritual murder includes a wide variety of both sacred and secular acts committed by groups and individuals and is most often attributed to practitioners of occult ideologies such as Satanism, Palo Mayombe, Santeria, and other magical traditions, or to serial killers and sexual sadists who ritually murder their victims. Due to many legal, practical, and ethical controversies the study of contemporary religious violence is in its infancy. There have been no serious empirical studies of ritualistic crimes or classifications that adequately distinguish between ritual homicides committed for sacred versus secular motivations.