Revision Notes in Psychiatry 2Nd Edition
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Anatomy of the Temporal Lobe
Hindawi Publishing Corporation Epilepsy Research and Treatment Volume 2012, Article ID 176157, 12 pages doi:10.1155/2012/176157 Review Article AnatomyoftheTemporalLobe J. A. Kiernan Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada N6A 5C1 Correspondence should be addressed to J. A. Kiernan, [email protected] Received 6 October 2011; Accepted 3 December 2011 Academic Editor: Seyed M. Mirsattari Copyright © 2012 J. A. Kiernan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Only primates have temporal lobes, which are largest in man, accommodating 17% of the cerebral cortex and including areas with auditory, olfactory, vestibular, visual and linguistic functions. The hippocampal formation, on the medial side of the lobe, includes the parahippocampal gyrus, subiculum, hippocampus, dentate gyrus, and associated white matter, notably the fimbria, whose fibres continue into the fornix. The hippocampus is an inrolled gyrus that bulges into the temporal horn of the lateral ventricle. Association fibres connect all parts of the cerebral cortex with the parahippocampal gyrus and subiculum, which in turn project to the dentate gyrus. The largest efferent projection of the subiculum and hippocampus is through the fornix to the hypothalamus. The choroid fissure, alongside the fimbria, separates the temporal lobe from the optic tract, hypothalamus and midbrain. The amygdala comprises several nuclei on the medial aspect of the temporal lobe, mostly anterior the hippocampus and indenting the tip of the temporal horn. The amygdala receives input from the olfactory bulb and from association cortex for other modalities of sensation. -
Table of Contents and Index
CONTENTS 1. Thinking about Space 1 2. The Ways of Light 7 3. Sensing Our Own Shape 51 4. Brain Maps and Polka Dots 69 5. Sherlock Ears 107 6. Moving with Maps and Meters 143 7. Your Sunglasses Are in the Milky Way 161 8. Going Places 177 9. Space and Memory 189 10. Thinking about Thinking 203 Notes 219 Acknowledgments 225 Credits 231 Index 237 Color illustrations follow page 86 Groh Corrected Pages.indd 7 7/15/14 9:09 AM INDEX Italicized page numbers refer to figures and their captions acalculia, 214 aqueous humor, 22, 30, 31 action potentials, 56–59, 57, 60, 61, 71–72, 74, Aristotle, 24, 180 94–96, 140, 146; electrically stimulating, astronomy, and discoveries regarding optics, 102; and memory, 191; in MT, 99; in 26–32. See also Brahe, Tycho; Kepler, superior colliculus, 154. See also spikes, Johannes electrical in neurons axon: conduction speed along, 95; as part of active sites, of proteins, 17 neuron, 71–73; paths traveled by, 77–78, adjusting to new glasses, 192–193 86, 91, 93 akinetopsia, 100 alcohol, effects on vestibular system, 183–184 balance, sense of, 175, 180–185. See also Alhazen, 8, 11–12 vestibular system aliasing, of sound, 123–125 barn owls, and hearing, 122, 137–138, 157, analog coding, in the brain, 146–147. See also Plate 7 digital coding, in the brain; maps, as form basilar membrane, resonance gradient of, of brain code; meters, as form of brain 139–140; and sound transduction, 109, 110 code bats, and echolocation, 131–132, 132 anechoic, 127 Bergen, Edgar, 135 ants, and navigation, 185–187, Plate 9 biased random walk, and navigation, 178. -
GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies
International Journal of Molecular Sciences Review GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects, and Current Therapies Andrés Felipe Leal 1 , Eliana Benincore-Flórez 1, Daniela Solano-Galarza 1, Rafael Guillermo Garzón Jaramillo 1 , Olga Yaneth Echeverri-Peña 1, Diego A. Suarez 1,2, Carlos Javier Alméciga-Díaz 1,* and Angela Johana Espejo-Mojica 1,* 1 Institute for the Study of Inborn Errors of Metabolism, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia; [email protected] (A.F.L.); [email protected] (E.B.-F.); [email protected] (D.S.-G.); [email protected] (R.G.G.J.); [email protected] (O.Y.E.-P.); [email protected] (D.A.S.) 2 Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 110231, Colombia * Correspondence: [email protected] (C.J.A.-D.); [email protected] (A.J.E.-M.); Tel.: +57-1-3208320 (ext. 4140) (C.J.A.-D.); +57-1-3208320 (ext. 4099) (A.J.E.-M.) Received: 6 July 2020; Accepted: 7 August 2020; Published: 27 August 2020 Abstract: GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside accumulation into the lysosome due to mutations on the genes encoding for the β-hexosaminidases subunits or the GM2 activator protein. Three GM2 gangliosidoses have been described: Tay–Sachs disease, Sandhoff disease, and the AB variant. Central nervous system dysfunction is the main characteristic of GM2 gangliosidoses patients that include neurodevelopment alterations, neuroinflammation, and neuronal apoptosis. Currently, there is not approved therapy for GM2 gangliosidoses, but different therapeutic strategies have been studied including hematopoietic stem cell transplantation, enzyme replacement therapy, substrate reduction therapy, pharmacological chaperones, and gene therapy. -
MRI Atlas of the Human Deep Brain Jean-Jacques Lemaire
MRI Atlas of the Human Deep Brain Jean-Jacques Lemaire To cite this version: Jean-Jacques Lemaire. MRI Atlas of the Human Deep Brain. 2019. hal-02116633 HAL Id: hal-02116633 https://hal.uca.fr/hal-02116633 Preprint submitted on 1 May 2019 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives| 4.0 International License MRI ATLAS of the HUMAN DEEP BRAIN Jean-Jacques Lemaire, MD, PhD, neurosurgeon, University Hospital of Clermont-Ferrand, Université Clermont Auvergne, CNRS, SIGMA, France This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. Terminologia Foundational Model Terminologia MRI Deep Brain Atlas NeuroNames (ID) neuroanatomica usages, classical and french terminologies of Anatomy (ID) Anatomica 1998 (ID) 2017 http://fipat.library.dal.ca In -
The Role of Selective Attention in Perceptual Switching By
The Role of Selective Attention in Perceptual Switching By Brenda Marie Stoesz A Thesis Submitted to the Faculty of Graduate Studies In Partial Fulfillment of the Requirements For the Degree of Master of Arts Department of Psychology University of Manitoba Winnipeg, Manitoba © Stoesz, Brenda M.; 2008 Perceptual Switching ii Abstract When viewing ambiguous figures, individuals can exert selective attentional control over their perceptual reversibility behaviour (e.g., Strüber & Stadler, 1999). In the current study, we replicated this finding but we also found that ambiguous figures containing faces are processed quite differently from those containing objects. Furthermore, inverting an ambiguous figure containing faces (i.e., Rubin’s vase-face) resulted in an “inversion effect”. These findings highlight the importance of considering how we attend to faces in addition to how we perceive and process faces. Describing the perceptual reversal patterns of individuals in the general population allowed us to draw comparisons to behaviours exhibited by individuals with Asperger Syndrome (AS). The group data suggested that these individuals were less affected by figure type or stimulus inversion. Examination of individual scores, moreover, revealed that the majority of participants with AS showed an atypical reversal pattern, particularly with ambiguous figures containing faces, and an atypical inversion effect. Together, our results show that ambiguous figures can be a very valuable tool for examining face processing mechanisms in the general population and other distinct groups of individuals, particularly those diagnosed with AS. Perceptual Switching iii Acknowledgements I would like to deeply thank my mentor, Dr. Lorna S. Jakobson, who, over the year that I have worked on this particular research project, provided me with much support and guidance. -
In This Research Report We Will Explore the Gestalt Principles and Their Implications and How Human’S Perception Can Be Tricked
The Gestalt Principles and there role in the effectiveness of Optical Illusions. By Brendan Mc Kinney Abstract Illusion are created in human perception in relation to how the mind process information, in this regard on to speculate that the Gestalt Principles are a key process in the success of optical illusions. To understand this principle the research paper will examine several optical illusions in the hopes that they exhibit similar traits used in the Gestalt Principles. In this research report we will explore the Gestalt Principles and their implications and how human’s perception can be tricked. The Gestalt Principles are the guiding principles of perception developed from testing on perception and how human beings perceive their surroundings. Human perception can however be tricked by understanding the Gestalt principles and using them to fool the human perception. The goal of this paper is to ask how illusions can be created to fool human’s perception using the gestalt principles as a basis for human’s perception. To examine the supposed, effect the Gestalt Principles in illusions we will look at three, the first being Rubin’s Vase, followed by the Penrose Stairs and the Kanizsa Triangle to understand the Gestalt Principles in play. In this context we will be looking at Optical Illusion rather than illusions using sound to understand the Gestalt Principles influence on human’s perception of reality. Illusions are described as a perception of something that is inconsistent with the actual reality (dictionary.com, 2015). How the human mind examines the world around them can be different from the actuality before them, this is due to the Gestalt principles influencing people’s perception. -
NTSAD Web Page on Miglustat Fran Platt Substrate Reduction Therapy
NTSAD Web Page on Miglustat Fran Platt Substrate Reduction Therapy for LSDs Background Several lysosomal storage diseases (LSDs) involve the storage of fatty molecules within cells of the body that are called sphingolipids (1). This is because an enzyme that normally works to break these molecules down in the lysosome, the waste disposal/recycling center of our cells, does not work properly (2, 3). Some sphingolipids are modified by the cells of our bodies by adding sugars, creating a family of specialized sphingolipids called glycosphingolipids (GSLs) (1). For example, in Gaucher disease a glycosphingolipid called glucosylceramide is not broken down and is stored, whereas in Tay-Sachs and Sandhoff disease it is a glycosphingolipid called GM2 ganglioside that is stored (1). Glycosphingolipids are made in the cells of our bodies by a single metabolic pathway that begins with the addition of a sugar molecule called glucose to a sphingolipid molecule called ceramide (1). The fact that there is only a single major pathway to make most glycosphingolipids offers a potential way of treating these diseases using a small molecule drug (4). How would a drug work? The principle behind this treatment is called substrate reduction therapy (SRT)(4). The idea is to partially block the cells in our body from making glycosphingolipids, specifically stopping them from adding glucose to ceramide, which is the first step in this pathway. This would mean fewer glycosphingolipids are made, so fewer would require breaking down in the lysosome. The aim is to balance the rates of glycosphingolipid manufacture with their impaired rate of breakdown. -
Springer Science+Business Media, LLC, Part of Springer Nature 2019 D
F Figure-Ground Segregation, Once figure-ground segmentation is achieved, Computational Neural the figure region often delineates a zone of addi- Models of tional attentive visual processing. Arash Yazdanbakhsh1 and Ennio Mingolla2 1 Computational Neuroscience and Vision Lab, Detailed Description Department of Psychological and Brain Sciences, Graduate Program for Neuroscience (GPN), The Importance of Figure-Ground Center for Systems Neuroscience (CSN), Center Segregation for Research in Sensory Communications and Visual function in animals has broadly increased Neural Technology (CReSCNT), Boston in complexity and competence across eons of University, Boston, MA, USA fi 2 evolution, with gure-ground perception being Department of Communication Sciences and among the later and more intriguing achieve- Disorders, Bouvé College of Health Sciences, ments of relatively sophisticated visual species. Northeastern University, Boston, MA, USA The importance of figure-ground perception can be seen by considering its advantages to animals that have the capability, as compared to the visual Definition limitations of animals whose visual systems do not support figure-ground perception (Land and Figure-ground segregation refers to the capacity Nilsson 2002). For example, the single-celled of a visual system to rapidly and reliably pick out euglena can use its eyespot and flagellum to orient for greater visual analysis, attention, or awareness, its locomotion in a light field, but it cannot take or preparation for motor action, a region of the account of the edges of individual objects in the visual field (figure) that is distinct from the com- sense of figure-ground for purposes of steering. bined areas of all the rest of the visual field Arrays of visual receptors that sample different (ground). -
The Figure Is in the Brain of the Beholder: Neural Correlates of Individual Percepts in The
The Figure is in the Brain of the Beholder: Neural Correlates of Individual Percepts in the Bistable Face-Vase Image A Thesis Presented to The Division of Philosophy, Religion, Psychology, and Linguistics Reed College In Partial Fulfillment of the Requirements for the Degree Bachelor of Arts Phoebe Bauer May 2015 Approved for the Division (Psychology) Michael Pitts Acknowledgments I think some people experience a degree of unease when being taken care of, so they only let certain people do it, or they feel guilty when it happens. I don’t really have that. I love being taken care of. Here is a list of people who need to be explicitly thanked because they have done it so frequently and are so good at it: Chris: thank you for being my support system across so many contexts, for spinning with me, for constantly reminding me what I’m capable of both in and out of the lab. Thank you for validating and often mirroring my emotions, and for never leaving a conflict unresolved. Rennie: thank you for being totally different from me and yet somehow understanding the depths of my opinions and thought experiments. Thank you for being able to talk about magic. Thank you for being my biggest ego boost and accepting when I internalize it. Ben: thank you for taking the most important classes with me so that I could get even more out of them by sharing. Thank you for keeping track of priorities (quality dining: yes, emotional explanations: yes, fretting about appearances: nu-uh). #AshHatchtag & Stella & Master Tran: thank you for being a ceaseless source of cheer and laughter and color and love this year. -
Do 3D Visual Illusions Work for Immersive Virtual Environments?
Do 3D Visual Illusions Work for Immersive Virtual Environments? Filip Skolaˇ Roman Gluszny Fotis Liarokapis CYENS – Centre of Excellence Solarwinds CYENS – Centre of Excellence Nicosia, Cyprus Brno, Czech Republic Nicosia, Cyprus [email protected] [email protected] [email protected] Abstract—Visual illusions are fascinating because visual per- The majority of visual illusions are generated by two- ception misjudges the actual physical properties of an image or dimensional pictures and their motions [9], [10]. But there are a scene. This paper examines the perception of visual illusions not a lot of visual illusions that make use of three-dimensional in three-dimensional space. Six diverse visual illusions were im- plemented for both immersive virtual reality and monitor based (3D) shapes [11]. Visual illusions are now slowly making their environments. A user-study with 30 healthy participants took appearance in serious games and are unexplored in virtual place in laboratory conditions comparing the perceptual effects reality. Currently, they are usually applied in the fields of brain of the two different mediums. Experimental data were collected games, puzzles and mini games. from both a simple ordering method and electrical activity of the However, a lot of issues regarding the perceptual effects brain. Results showed unexpected outcomes indicating that only some of the illusions have a stronger effect in immersive virtual are not fully understood in the context of digital games. reality, others in monitor based environments while the rest with An overview of electroencephalography (EEG) based brain- no significant effects. computer interfaces (BCIs) and their present and potential Index Terms—virtual reality, visual illusions, perception, hu- uses in virtual environments and games has been recently man factors, games documented [12]. -
References and Further Reading
110_Valk_References 13.04.2005 12:37 Uhr Seite 905 References and Further Reading 1 Myelin and White Matter Dambska M,Laure-Kaminowska M.Myelination as a parameter of normal and retarded brain maturation. Brain Dev 1990; Asotra K, Macklin WB. Protein kinase C activity modulates 12: 214–220 myelin gene expression in enriched oligodendrocytes. Davison AN, Dobbing J. Myelination as a vulnerable period in J Neurosci Res 1993; 34: 571–588 brain development. Br Med Bull 1966; 20: 40–44 Baumann N, Pham-Dinh D. Biology of oligodendrocyte and Deshmukh DS,Vorbrodt AW,Lee PK,Bear WD,Kuizon S.Studies myelin in the mammalian central nervous system. Physiol on the submicrosomal fractions of bovine oligodendroglia: Rev 2001; 81: 871–927 lipid composition and glycolipid biosynthesis. Neurochem Benjamins JA, Iwata R, Hazlett J. Kinetics of entry of proteins Res 1988; 13: 571–582 into the myelin membrane. J Neurochem 1978; 31: 1077– De Vries GH, Norton WT. The fatty acid composition of sphin- 1085 golipids from bovine CNS axons and myelin. J Neurochem Benveniste EN, Merrill JE. Stimulation of oligodendroglial pro- 1974; 22: 251–257 liferation and maturation by interleukin-2. Nature 1986; Dietrich RB, Bradley WG, Zaragoza IV, Otto RJ, Taira RK, Wilson 321: 610–613 GH, Kangerloo H. MR evaluation of early myelination pat- Berlet HH,Volk B.Studies of human myelin proteins during old terns in normal and developmentally delayed infants.AJNR age. Mech Ageing Dev 1980; 14: 211–222 Am J Neuroradiol 1988; 9: 69–76 Berndt JA, Kim JG, Hudson LD. Identification of cis-regulatory Dobbing J.Vulnerable periods in developing brain.In: Davison elements in the myelin proteolipid protein (PLP) gene. -
The Nomenclature of Human White Matter Association Pathways: Proposal for a Systematic Taxonomic Anatomical Classification
The Nomenclature of Human White Matter Association Pathways: Proposal for a Systematic Taxonomic Anatomical Classification Emmanuel Mandonnet, Silvio Sarubbo, Laurent Petit To cite this version: Emmanuel Mandonnet, Silvio Sarubbo, Laurent Petit. The Nomenclature of Human White Matter Association Pathways: Proposal for a Systematic Taxonomic Anatomical Classification. Frontiers in Neuroanatomy, Frontiers, 2018, 12, pp.94. 10.3389/fnana.2018.00094. hal-01929504 HAL Id: hal-01929504 https://hal.archives-ouvertes.fr/hal-01929504 Submitted on 21 Nov 2018 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. REVIEW published: 06 November 2018 doi: 10.3389/fnana.2018.00094 The Nomenclature of Human White Matter Association Pathways: Proposal for a Systematic Taxonomic Anatomical Classification Emmanuel Mandonnet 1* †, Silvio Sarubbo 2† and Laurent Petit 3* 1Department of Neurosurgery, Lariboisière Hospital, Paris, France, 2Division of Neurosurgery, Structural and Functional Connectivity Lab, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy, 3Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives—UMR 5293, CNRS, CEA University of Bordeaux, Bordeaux, France The heterogeneity and complexity of white matter (WM) pathways of the human brain were discretely described by pioneers such as Willis, Stenon, Malpighi, Vieussens and Vicq d’Azyr up to the beginning of the 19th century.