List of Primer Oligos for Qpcr Analysis Gene Forward

SUPPLEMENTARY DATA

Supplementary Table 1: List of Primer Oligos for qPCR analysis

Gene Forward (5’->3’) Reverse (5’->3’)

HPRT1 GAAAAGGACCCCACGAAGTGT AGTCAAGGGCATATCCTACAA

B2M TGTCTTTCAGCAAGGACTGG AGCAAGCAAGCAGAATTTGG

RPLP0 TGTTTCATTGTGGGAGCAGA GAACACAAAGCCCACATTCC

GAPDH TGCACCACCAACTGCTTAGC GGCATGGACTGTGGTCATGAG

DAPK3 AATCTGAGGAGCTGGGTTGC TCCAGGGAAAGTGCAGTCAC

ATP2A3 AGTGCTCCGAAGACAACCC GTTCTCCGAGACGCTGTTG

PPIB ATGTAGGCCGGGTGATCTTT CATCTCCCCTGGTGAAGTCT

TBP AGTTCTGGGATTGTACCGCA TATATTCGGCGTTTCGGGCA mRNA was harvested from cultured myotubesusing a kit (E.Z.N.A. Total RNA Kit 1, Omega bio-tek, Norcross, GA). Reverse transcription and quantitative PCR were carried out using MultiScribe Reverse Transcriptase and Fast SYBR Green Master Mix, respectively (Thermo Fisher Scientific). Gene expression of ATP2A3, DAPK3, and reference genes (PPIB, TBP) was assessed using self-designed oligonucleotides (Sigma-Aldrich).

Supplementary Table 2: List of Antibodies used for Western-blot analysis

Target Vendor Product Number

PKB p-Thr-308 Cell Signaling (Danvers, MA) 4056

PKB total Cell Signaling 9272

TBC1D4 p-Ser-318 Cell Signaling 8619

TBC1D4 total Merck Millipore (Billerica, MA) 07-741

p62 Sigma-Aldrich P0067

LC3 Sigma-Aldrich L8918

GAPDH Santa Cruz Biotechnology (Dallas, TX) sc-257758

Myotube lysates were diluted in Laemmli buffer (60 mMtris base at pH 6.8, 2% w/v SDS, 10% v/v glycerol, 0.01% w/v bromophenol blue, 1.25% v/v β-mercaptoethanol). SDS-PAGE was conducted using pre-cast tris-HCl and tris-bis gels with tris/glycine/SDS or 2-(N-morpholino)ethanesulfonic acid running buffers, respectively (Bio-Rad). Proteins were transferred to Immobilon-P PVDF membranes (Merck Millipore). Equal loading of protein between samples was assessed by Ponceau staining (Sigma- Aldrich) or fluorescent-detection in the case of stain-free gels (Bio-Rad). Membranes were washed in tris-buffered saline (TBS) with Tween-20 (Sigma-Aldrich) (TBST) (20 mMtris at pH 7.6, 137 mMNaCl, 0.02% v/v Tween-20). Membranes were blocked in 7.5% non-fat dry milk, washed again in TBST, then incubated with primary antibodies overnight at 4°C (1:1000 in TBS with 0.1% w/v bovine serum albumin, 0.1% w/v NaN3). Membranes were washed again in TBST, incubated with horseradish peroxidase-conjugated secondary antibodies (1:25000 in TBST with 4% NFDM; Thermo Fisher Scientific) for 1-2 hours at room temperature and then washed in TBST. Immunolabeled bands were visualized using extended chemiluminescence reagents (GE Healthcare) and autoradiograms were quantitated by scanning densitometry using Image Lab software (Bio-Rad).

Supplementary Table 3: t-tests (unpaired & paired, 2-sided Gene Name RELATION_TO_ M value Beta value name of the UCSC_CPG_ISLA target_ID difference difference p_unpaired p_paired closest gene UCSC_REFGENE_GROUP UCSC_CPG_ISLANDS_NAME ND cg03312587 -0.2728 0.0361 0.0122 0.0207 A2BP1 5'UTR;5'UTR;5'UTR cg20307184 0.6291 -0.0475 0.0287 0.0113 ABCA13 Body cg07372195 0.9867 -0.0462 0.0111 0.0239 ABCA5 5'UTR;1stExon;5'UTR cg14647845 0.4657 -0.0323 0.0181 0.0040 ABLIM2 Body;Body;Body;Body;Body;Body;Body cg20497635 1.0417 -0.0930 0.0345 0.0094 ABR Body;Body;Body cg13686847 -0.4127 0.0310 0.0203 0.0239 ACACB Body cg06698843 -0.5306 0.0403 0.0314 0.0164 ACADS Body chr12:121177115-121177341 N_Shelf cg07343187 -0.8390 0.0336 0.0399 0.0498 ACAN Body;Body cg16380285 -0.6346 0.0318 0.0106 0.0139 ACAP3 3'UTR chr1:1228780-1230163 N_Shore cg04854749 -0.2989 0.0420 0.0002 0.0006 ACIN1 Body;Body;Body;Body;Body chr14:23528360-23528582 S_Shore cg22402043 0.7627 -0.0487 0.0272 0.0044 ACP6 Body chr1:147141842-147142918 N_Shelf cg17541674 -0.3461 0.0661 0.0095 0.0113 ACPT Body chr19:51294876-51295098 S_Shore

TSS1500;TSS1500;TSS1500;TSS1500;TSS150 cg07665222 0.5427 -0.0509 0.0032 0.0095 ACRV1 0;TSS1500;TSS1500;TSS1500;TSS1500 cg04252928 0.4396 -0.0412 0.0491 0.0049 ACSF3 Body;Body;Body chr16:89167116-89167482 S_Shore cg02009395 0.3747 -0.0423 0.0490 0.0246 ACSM1 TSS200 cg03369957 0.5781 -0.0794 0.0448 0.0469 ACTL6B Body chr7:100253782-100254150 N_Shore cg18862171 0.7014 -0.0449 0.0088 0.0009 ACTN3 TSS200;TSS1500 chr11:66314207-66314455 Island cg04738270 0.7167 -0.0537 0.0053 0.0172 ACTR1A Body chr10:104262224-104262524 N_Shore cg21577356 -0.4103 0.0406 0.0038 0.0046 ACTR3C TSS1500;5'UTR;5'UTR chr7:150019950-150020752 S_Shore cg04892170 0.7435 -0.0300 0.0232 0.0108 ADAM12 1stExon;5'UTR;5'UTR;1stExon chr10:128076155-128077482 Island cg05847038 0.7683 -0.0500 0.0405 0.0247 ADAM7 Body cg16451601 0.7209 -0.0577 0.0234 0.0446 ADAMTS2 Body;Body cg01260219 -0.3110 0.0414 0.0019 0.0295 ADAMTS8 TSS1500 chr11:130297401-130298517 S_Shore cg21170978 0.7111 -0.0340 0.0454 0.0314 ADAMTSL1 Body cg01629749 0.4718 -0.0651 0.0323 0.0262 ADAP1 Body chr7:959724-959959 Island cg04233620 -0.8087 0.0847 0.0106 0.0195 ADARB1 Body;Body;Body;Body;Body;Body;Body cg00615654 0.8293 -0.0706 0.0081 0.0201 ADARB2 Body chr10:1382500-1383006 N_Shore cg11637718 -0.4758 0.0424 0.0004 0.0063 ADCY9 Body chr16:4029157-4029413 Island

cg16230755 -0.3191 0.0309 0.0243 0.0312 ADD3 5'UTR;5'UTR;5'UTR cg05727225 -0.3990 0.0446 0.0207 0.0274 ADM Body chr11:10327013-10329831 Island cg25320816 -0.3776 0.0529 0.0130 0.0168 ADPRHL1 5'UTR;Body chr13:114096050-114096317 S_Shelf cg11367939 -0.4440 0.0361 0.0099 0.0220 ADRA2A 3'UTR;1stExon chr10:112835990-112839303 Island cg22275864 0.7223 -0.0492 0.0303 0.0395 ADRB3 Body chr8:37822486-37824008 Island cg16389474 0.5792 -0.0369 0.0241 0.0009 ADRM1 5'UTR;5'UTR chr20:60877499-60879008 Island cg10028549 -0.3009 0.0419 0.0319 0.0136 AFAP1 TSS1500;TSS1500 chr4:7940563-7941853 S_Shore cg02441982 0.6113 -0.0419 0.0234 0.0015 AFMID Body;TSS1500;Body;Body chr17:76183077-76183449 S_Shore cg27436044 -0.3079 0.0301 0.0104 0.0095 AGA Body chr4:178363239-178363708 N_Shelf cg13018278 -0.1426 0.0359 0.0461 0.0030 AGAP1 Body;Body chr2:237028848-237029121 Island cg22199080 -0.5048 0.0814 0.0437 0.0293 AGAP2 1stExon chr12:58130870-58132047 S_Shelf cg01338043 -0.4313 0.0608 0.0176 0.0379 AGFG2 TSS1500 chr7:100136448-100136919 N_Shore cg20352108 0.5140 -0.0536 0.0270 0.0010 AGPAT4 5'UTR cg03120284 -0.8278 0.0888 0.0464 0.0191 AGRN Body chr1:990274-990694 N_Shelf cg09745307 0.5330 -0.0353 0.0040 0.0250 AGXT2 TSS1500 cg04911680 0.5029 -0.0316 0.0216 0.0013 AHDC1 5'UTR chr1:27894927-27895524 Island cg21267167 0.3733 -0.0387 0.0094 0.0034 AJAP1 Body;Body cg17181543 0.5245 -0.0303 0.0451 0.0229 AK5 TSS1500 chr1:77747314-77748224 N_Shore cg27090975 0.2071 -0.0339 0.0223 0.0156 AKAP8L Body chr19:15512025-15512393 S_Shelf cg24455383 -0.3794 0.0748 0.0257 0.0052 AKT3 Body;Body cg14469290 1.0575 -0.1133 0.0332 0.0092 ALAD TSS1500 chr9:116163208-116163848 S_Shore cg16086130 -0.9008 0.0976 0.0047 0.0043 ALDH1A3 TSS1500 chr15:101419261-101421133 Island cg02946394 -0.3862 0.0407 0.0423 0.0431 ALOXE3 Body;Body chr17:8012474-8012846 N_Shore cg11441891 0.7929 -0.0395 0.0192 0.0019 ALS2CL TSS1500;Body cg02562052 1.6860 -0.1228 0.0044 0.0270 ALS2CR4 TSS200;TSS1500 chr2:202507139-202508270 S_Shore cg16893614 0.7877 -0.0554 0.0199 0.0398 ALX3 TSS1500 chr1:110610265-110613303 S_Shore cg00268840 -1.0339 0.0505 0.0249 0.0359 ALX4 TSS1500 chr11:44332314-44332757 Island cg21101750 0.6357 -0.0596 0.0334 0.0231 AMBRA1 TSS1500 chr11:46615197-46615664 N_Shore cg01636354 -0.4430 0.0731 0.0046 0.0421 AMOTL2 Body chr3:134080390-134080596 N_Shore cg12756093 -0.4006 0.0754 0.0015 0.0065 AMPD1 TSS1500 cg24435741 -0.4782 0.0454 0.0246 0.0204 AMPD3 TSS1500 chr11:10472000-10472857 N_Shore Body;5'UTR;1stExon;3'UTR;1stExon;1stExon cg02251567 -0.3202 0.0745 0.0044 0.0271 AMT ;5'UTR;5'UTR;1stExon;5'UTR

cg01186212 0.6372 -0.0340 0.0421 0.0175 ANK3 Body cg14455319 0.2916 -0.0431 0.0375 0.0181 ANKK1 Body chr11:113258443-113258821 S_Shore cg04035353 -0.6295 0.0497 0.0055 0.0178 ANKRD11 Body chr16:89334574-89335088 S_Shore cg13718961 0.3988 -0.0332 0.0200 0.0188 ANKRD13B Body chr17:27939298-27940770 N_Shore cg01635821 0.5661 -0.0347 0.0476 0.0114 ANKRD46 5'UTR chr8:101571515-101572104 N_Shore cg00515408 0.6839 -0.0569 0.0034 0.0258 ANKS1B 5'UTR;1stExon chr12:100378243-100378582 N_Shore cg14938313 -0.4778 0.0431 0.0337 0.0176 ANO1 Body;Body cg15476875 0.6279 -0.0463 0.0054 0.0222 ANO4 Body cg00363845 0.5519 -0.0836 0.0162 0.0446 ANO8 TSS1500 chr19:17443965-17444633 S_Shore cg05998672 0.4527 -0.0316 0.0426 0.0030 AP2A2 Body cg01632240 -0.1981 0.0307 0.0155 0.0067 AP3M2 TSS1500;TSS1500 chr8:42009723-42011098 N_Shore cg14907738 0.3881 -0.0316 0.0092 0.0207 APC2 Body chr19:1456077-1456347 Island cg03624661 -0.7388 0.0314 0.0005 0.0159 APH1B TSS1500;TSS1500 chr15:63569296-63570100 Island cg16353361 -0.5892 0.0507 0.0143 0.0123 APLN TSS1500 chrX:128788003-128789195 S_Shore cg13880303 0.4886 -0.1007 0.0280 0.0195 APOC1 TSS200 cg20691580 -0.5979 0.0348 0.0093 0.0495 APOC3 5'UTR cg04006839 -0.5281 0.0373 0.0152 0.0237 APOH 1stExon cg19599611 0.5928 -0.0369 0.0274 0.0423 AQR 3'UTR cg09120188 0.6820 -0.0357 0.0227 0.0275 ARHGAP23 Body cg15368044 -0.2989 0.0409 0.0408 0.0050 ARHGAP26 Body;Body cg00402547 0.9041 -0.0549 0.0038 0.0487 ARHGAP28 5'UTR;5'UTR cg07837534 -0.4113 0.0656 0.0007 0.0139 ARHGAP30 Body;Body cg06015525 -0.8355 0.0439 0.0255 0.0204 ARHGAP9 Body;Body;TSS1500 chr12:57869075-57870182 S_Shore cg22062741 0.3656 -0.0303 0.0027 0.0013 ARHGEF10 Body chr8:1893696-1894083 S_Shelf cg19537511 -0.2371 0.0413 0.0012 0.0235 ARHGEF15 5'UTR cg08929791 -0.3065 0.0303 0.0125 0.0269 ARHGEF19 5'UTR chr1:16532917-16534580 S_Shore cg23919844 0.5460 -0.0338 0.0484 0.0337 ARHGEF7 Body;5'UTR;Body;Body cg02001279 -0.4875 0.0894 0.0429 0.0193 ARID3A Body chr19:940723-942490 Island cg18975055 -0.4284 0.0520 0.0079 0.0175 ARRB1 3'UTR;3'UTR cg23779331 1.0897 -0.0699 0.0135 0.0338 ARRB2 Body;Body chr17:4613400-4614423 Island cg14335435 0.9738 -0.0422 0.0128 0.0014 ARRDC4 Body cg22193089 1.0426 -0.0444 0.0037 0.0482 ARSG 5'UTR chr17:66255192-66255556 S_Shelf cg24056730 0.7071 -0.0616 0.0473 0.0129 ART3 TSS1500;TSS1500;5'UTR

cg23212751 0.8714 -0.0695 0.0203 0.0284 ARTN TSS1500;Body;Body;Body;Body chr1:44401757-44402423 N_Shore cg18513624 0.5113 -0.0358 0.0369 0.0426 ARVCF Body chr22:19974274-19974756 Island cg16414561 -1.0241 0.0354 0.0003 0.0038 ARX 1stExon;5'UTR chrX:25033664-25034712 Island cg06404572 0.6670 -0.0677 0.0043 0.0071 ASAP1 Body chr8:131370087-131371317 S_Shelf cg10903916 0.5699 -0.0470 0.0237 0.0081 ASAP2 Body;Body chr2:9533572-9533807 N_Shore cg12724466 -0.4413 0.0969 0.0351 0.0177 ASB11 TSS1500;1stExon cg24074054 0.1913 -0.0329 0.0196 0.0345 ASF1B Body chr19:14246899-14248520 N_Shore cg19619206 -0.4352 0.0434 0.0036 0.0307 ASGR2 5'UTR;5'UTR;1stExon;5'UTR;5'UTR cg18159819 -0.6957 0.0504 0.0236 0.0423 ASRGL1 Body;Body chr11:62138621-62138873 S_Shore cg13978347 0.4576 -0.0321 0.0005 0.0117 ASTN2 Body;Body;Body cg11794959 -0.1507 0.0305 0.0260 0.0092 ATAD3A 5'UTR;Body;Body chr1:1452701-1453199 N_Shore cg15688683 0.6093 -0.0394 0.0163 0.0311 ATAD3B Body cg27563529 0.8191 -0.0389 0.0119 0.0277 ATF7 3'UTR;3'UTR;3'UTR cg13858127 0.7489 -0.0600 0.0046 0.0433 ATP11A Body;Body chr13:113497296-113497661 S_Shore cg05808709 -0.5070 0.0831 0.0141 0.0288 ATP1A2 Body cg07807695 -0.3289 0.0590 0.0081 0.0036 ATP6AP1L Body cg04726373 -0.5797 0.0434 0.0230 0.0264 ATP6V0D1 Body chr16:67514398-67515345 N_Shore cg13100918 0.8528 -0.0449 0.0105 0.0333 ATP8A1 Body;Body chr4:42658278-42659550 N_Shelf cg26048101 0.7194 -0.0827 0.0137 0.0261 ATP9A Body cg16904686 -0.4187 0.0418 0.0329 0.0199 ATPAF1 Body;Body chr1:47133674-47134395 N_Shore cg07225277 -0.3604 0.0365 0.0005 0.0037 ATPGD1 Body;Body chr11:67188087-67188879 Island ch.X.1171704R 1.2776 -0.0796 0.0087 0.0446 ATRX Body;Body cg14791639 -0.2978 0.0393 0.0382 0.0111 ATXN1 5'UTR;5'UTR cg19465374 -0.2831 0.0427 0.0100 0.0358 AZGP1 Body cg02069944 -0.4221 0.0512 0.0073 0.0184 AZI1 Body;Body cg05973866 -0.7722 0.0399 0.0023 0.0228 B3GALT4 TSS1500 chr6:33244677-33245554 Island cg16756854 0.6394 -0.0329 0.0313 0.0066 B3GNT1 TSS1500 chr11:66114497-66115525 S_Shore cg22535523 0.5672 -0.0318 0.0111 0.0047 BAHCC1 Body chr17:79380359-79380723 S_Shelf cg09544050 0.3782 -0.0688 0.0406 0.0123 BAI1 Body chr8:143580769-143580975 Island cg19176696 -0.5623 0.0427 0.0119 0.0262 BAIAP2 Body;Body;Body;Body cg23598068 -0.3009 0.0389 0.0261 0.0154 BAIAP2L1 Body cg05781294 0.8806 -0.0622 0.0216 0.0202 BAT1 Body;TSS200;Body cg18685724 -0.5657 0.0790 0.0099 0.0229 BAT2 TSS1500 chr6:31587779-31589024 Island

cg13873889 -0.5319 0.0450 0.0179 0.0003 BAT3 Body;Body;Body;Body cg08319238 0.5345 -0.0353 0.0175 0.0465 BCAM Body;Body chr19:45312059-45312397 S_Shore cg08465120 0.7182 -0.1350 0.0404 0.0090 BCAN Body chr1:156627342-156627576 Island cg10172669 -0.5399 0.0307 0.0207 0.0165 BEND4 1stExon;5'UTR;5'UTR;1stExon chr4:42152766-42154984 Island cg23032598 0.6907 -0.0685 0.0069 0.0016 BFSP1 Body;TSS1500 chr20:17511478-17512209 S_Shore cg09177577 0.6398 -0.0772 0.0162 0.0094 BIN3 Body cg16925678 -0.5001 0.0539 0.0044 0.0310 BIRC7 3'UTR;3'UTR chr20:61870781-61871178 Island cg22047703 0.7753 -0.0358 0.0311 0.0333 BMP7 TSS200 chr20:55840216-55841794 S_Shore cg07843733 0.5850 -0.0372 0.0275 0.0135 BRAF Body cg13782816 0.4537 -0.0496 0.0257 0.0432 BRCA1 Body;Body;5'UTR;1stExon;Body;Body chr17:41278134-41278460 N_Shelf cg10835365 1.1917 -0.0727 0.0217 0.0121 BRD1 Body chr22:50169612-50169864 Island cg02935097 -0.2705 0.0452 0.0088 0.0270 BRDT TSS200 chr1:92414718-92414986 Island cg26318206 -0.2705 0.0579 0.0360 0.0412 BRF1 Body chr14:105738159-105738664 N_Shelf cg11529614 0.6081 -0.0374 0.0103 0.0270 BRIP1 TSS1500 chr17:59940825-59941067 Island cg22849672 0.5697 -0.0349 0.0468 0.0078 BRP44L Body chr6:166795368-166797301 N_Shelf cg14746118 0.7733 -0.0783 0.0051 0.0286 BRS3 TSS1500 cg03695103 0.9083 -0.0913 0.0135 0.0394 BRSK2 Body chr11:1471339-1471595 Island cg13408027 -0.3966 0.0305 0.0028 0.0277 BSPRY 3'UTR cg17170819 0.4966 -0.0348 0.0288 0.0355 BTBD17 3'UTR chr17:72352827-72353798 N_Shore cg16870622 -0.6618 0.0454 0.0217 0.0046 BTBD2 3'UTR chr19:1985880-1986198 Island cg21391023 0.4242 -0.0505 0.0032 0.0092 BTBD8 TSS1500 chr1:92545819-92546480 N_Shore cg19281794 0.8365 -0.0566 0.0291 0.0458 BTLA TSS1500;TSS1500 cg21432745 0.6478 -0.0354 0.0119 0.0399 BTN3A2 3'UTR cg21369812 0.5280 -0.0532 0.0349 0.0337 C10orf105 3'UTR;3'UTR;Body cg03522510 -0.5612 0.0345 0.0318 0.0360 C10orf107 5'UTR chr10:63422538-63423105 S_Shore cg03448754 0.3489 -0.0352 0.0162 0.0438 C10orf11 TSS1500 cg12518630 0.8376 -0.0558 0.0001 0.0078 C10orf12 TSS1500 cg24291461 0.5544 -0.0429 0.0152 0.0469 C10orf2 Body;Body;Body;Body chr10:102748870-102749088 S_Shore cg03275084 0.4482 -0.0313 0.0036 0.0201 C10orf32 Body;Body chr10:104614000-104614326 S_Shelf cg11824509 -0.7859 0.1248 0.0023 0.0224 C10orf57 TSS1500;Body;Body;Body;Body;Body chr10:81838359-81839078 N_Shore cg14618310 -0.6362 0.0638 0.0427 0.0145 C10orf84 3'UTR;3'UTR cg07780895 -0.4798 0.0542 0.0149 0.0172 C10orf93 Body chr10:134755663-134756852 N_Shore cg02789688 -0.5474 0.0348 0.0294 0.0116 C11orf45 TSS1500;5'UTR

cg03019460 0.6012 -0.0304 0.0304 0.0418 C11orf51 5'UTR chr11:71823668-71823975 N_Shore cg03847768 1.0103 -0.0784 0.0045 0.0146 C12orf35 TSS1500 chr12:32112161-32112833 N_Shore cg07979579 0.8547 -0.0624 0.0400 0.0477 C13orf1 Body;3'UTR;3'UTR cg03135713 0.5759 -0.0506 0.0163 0.0175 C13orf18 TSS1500 chr13:46960684-46961670 S_Shore cg22032900 -0.5351 0.0361 0.0010 0.0023 C13orf35 1stExon;5'UTR chr13:113303306-113303540 N_Shore cg03565081 -0.4462 0.0666 0.0032 0.0321 C14orf93 5'UTR;5'UTR;5'UTR chr14:23479310-23479532 N_Shore cg25710630 0.5209 -0.0313 0.0039 0.0018 C15orf23 Body;Body;3'UTR cg01818102 0.8107 -0.0389 0.0041 0.0071 C16orf45 TSS1500;Body cg16578568 -0.2712 0.0510 0.0017 0.0012 C16orf54 TSS200 cg08734647 0.8783 -0.0588 0.0110 0.0443 C16orf73 TSS1500;TSS1500 chr16:1921897-1922426 Island cg08358426 -0.2926 0.0586 0.0173 0.0168 C16orf79 TSS1500;3'UTR chr16:2263912-2265428 N_Shore cg07150585 0.8218 -0.0484 0.0200 0.0225 C16orf90 TSS1500 chr16:3546366-3546769 Island cg19196735 0.9906 -0.0601 0.0031 0.0042 C17orf108 5'UTR chr17:26219938-26220475 N_Shelf cg15532088 -0.5005 0.0589 0.0448 0.0361 C17orf66 Body cg03284113 0.7326 -0.0515 0.0453 0.0468 C19orf26 Body chr19:1234938-1235231 Island cg08399733 -0.5983 0.0327 0.0054 0.0392 C19orf35 Body chr19:2278605-2278848 Island cg22627406 -0.3462 0.0451 0.0049 0.0124 C19orf38 TSS200 cg22642495 -0.3375 0.0557 0.0380 0.0168 C19orf66 Body chr19:10196696-10197857 Island cg20433455 -0.3213 0.0406 0.0045 0.0397 C1orf144 Body;Body cg02907021 -0.9137 0.0488 0.0351 0.0313 C1orf198 Body;5'UTR;Body cg08843859 0.7559 -0.0420 0.0274 0.0198 C1orf21 Body cg08910524 0.6542 -0.0333 0.0310 0.0328 C1orf27 5'UTR;5'UTR;Body;5'UTR chr1:186344124-186344848 S_Shelf cg16684817 -0.4966 0.0620 0.0063 0.0213 C1orf38 Body;Body;Body chr1:28199031-28199257 S_Shelf cg15642292 0.9889 -0.0517 0.0168 0.0456 C1orf51 TSS1500 chr1:150254365-150254637 N_Shore cg06794398 0.6462 -0.0316 0.0017 0.0052 C1orf85 TSS200 cg27332111 1.4373 -0.0421 0.0118 0.0023 C1orf91 TSS1500;Body chr1:32687521-32688040 S_Shore cg24484138 0.2645 -0.0303 0.0340 0.0062 C20orf112 5'UTR chr20:31070189-31072676 Island cg22963777 -0.5801 0.0608 0.0154 0.0297 C20orf173 3'UTR;Body cg19333980 0.2634 -0.0416 0.0062 0.0444 C20orf30 TSS1500;TSS1500;TSS1500;TSS1500 chr20:5093360-5094145 S_Shore cg03908688 -0.4591 0.0524 0.0243 0.0015 C20orf54 Body chr20:741633-742058 S_Shore cg04677846 0.2059 -0.0326 0.0353 0.0380 C21orf33 Body;Body chr21:45560662-45560999 Island cg17136243 0.5093 -0.0373 0.0127 0.0044 C22orf39 3'UTR cg03396285 1.0475 -0.0417 0.0350 0.0001 C2orf29 TSS1500 chr2:101869023-101869876 N_Shore

cg20712489 1.0528 -0.0716 0.0087 0.0322 C2orf83 3'UTR;3'UTR cg24290756 -0.4075 0.0723 0.0174 0.0263 C2orf85 TSS1500 chr2:242815056-242815599 N_Shelf cg09613130 -0.7663 0.0469 0.0035 0.0157 C2orf90 3'UTR;1stExon cg13868855 -0.3926 0.0465 0.0188 0.0266 C3orf21 Body cg15083578 0.5995 -0.0473 0.0037 0.0386 C3orf23 3'UTR cg07472196 0.6088 -0.0407 0.0077 0.0322 C3orf26 Body;5'UTR;5'UTR cg00577147 0.8510 -0.0381 0.0180 0.0237 C3orf31 TSS1500 chr3:11887799-11888538 S_Shore cg01436664 -0.4632 0.0322 0.0492 0.0238 C3orf37 1stExon;5'UTR;5'UTR chr3:128997958-128998303 N_Shore cg13197078 0.4698 -0.0363 0.0463 0.0268 C4B Body;Body cg10183150 0.4135 -0.0487 0.0442 0.0397 C4orf3 Body;TSS1500 chr4:120221626-120222007 S_Shore cg25222324 -0.3514 0.0310 0.0086 0.0142 C4orf36 3'UTR cg06034548 -0.3210 0.0571 0.0105 0.0157 C5orf27 Body cg01983248 0.6482 -0.0636 0.0271 0.0481 C5orf28 5'UTR chr5:43483519-43484555 N_Shore cg06430061 0.3741 -0.0472 0.0032 0.0215 C5orf37 TSS1500 chr5:75012962-75013515 S_Shore cg04657419 -0.5175 0.0348 0.0146 0.0370 C5orf43 3'UTR chr5:60457840-60458654 N_Shelf cg02351082 -0.3303 0.0587 0.0288 0.0133 C5orf60 3'UTR cg06192961 0.2227 -0.0386 0.0014 0.0103 C6orf10 Body cg09931909 0.9990 -0.0706 0.0472 0.0452 C6orf150 Body chr6:74161086-74162090 N_Shore cg04972856 0.7734 -0.0625 0.0387 0.0383 C6orf162 TSS1500;5'UTR;TSS1500 chr6:88032157-88032429 N_Shore cg17731470 0.5361 -0.0482 0.0321 0.0163 C6orf25 Body;Body;Body;Body;Body;Body chr6:31691425-31691718 S_Shore cg08092333 -0.6970 0.0460 0.0242 0.0353 C7orf27 Body chr7:2594724-2595538 N_Shelf cg13544405 1.0793 -0.0756 0.0306 0.0251 C7orf29 1stExon;5'UTR;5'UTR;3'UTR cg05343453 0.5280 -0.0368 0.0339 0.0204 C7orf45 TSS1500 chr7:129845146-129845424 S_Shore cg22277106 0.4076 -0.0441 0.0481 0.0014 C7orf50 Body;Body;Body;1stExon chr7:1097405-1097953 Island cg19472770 0.5080 -0.0448 0.0367 0.0353 C7orf51 TSS1500 chr7:100080693-100081371 N_Shore cg02102080 0.6135 -0.0538 0.0068 0.0131 C8orf33 3'UTR chr8:146277254-146277491 S_Shelf cg21926804 -0.3547 0.0585 0.0492 0.0101 C8orf74 Body cg07337434 0.8949 -0.0749 0.0039 0.0061 C9orf135 TSS1500 cg01251476 -0.7385 0.0420 0.0473 0.0358 C9orf40 Body chr9:77566773-77568038 N_Shore cg04517374 1.0510 -0.0869 0.0081 0.0360 CABLES2 Body chr20:60982405-60982780 N_Shore cg05308117 -0.2622 0.0467 0.0207 0.0071 CABP5 TSS200 cg20099906 0.5321 -0.0568 0.0232 0.0433 CACNA1A Body;Body chr19:13346962-13347346 N_Shelf cg24052239 0.4564 -0.0403 0.0003 0.0115 CACNA1F Body chrX:49087209-49087520 Island

cg27000853 -0.5709 0.0416 0.0403 0.0092 CACNA1H Body;Body chr16:1209939-1210945 S_Shore cg16915733 0.6431 -0.0531 0.0373 0.0101 CADPS Body;Body;Body cg22430036 -0.3595 0.0489 0.0065 0.0357 CALD1 Body;Body;Body;Body;Body cg17832674 0.7860 -0.0369 0.0326 0.0499 CALM3 TSS1500 chr19:47103786-47104864 N_Shore cg10509407 0.6344 -0.0632 0.0020 0.0161 CALN1 Body;Body cg21078247 0.2977 -0.0393 0.0084 0.0025 CAMK2D Body;Body;Body;Body;Body;Body cg01776391 1.0670 -0.0505 0.0032 0.0274 CAMKK1 Body;Body;Body chr17:3771284-3771676 Island cg03865604 -0.3587 0.0398 0.0268 0.0215 CAMKK2 5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR cg05998153 -0.4124 0.0305 0.0281 0.0187 CAMLG Body chr5:134074083-134074494 S_Shore cg26251680 -0.1663 0.0337 0.0177 0.0395 CAMTA1 Body cg12056772 -0.3916 0.0578 0.0186 0.0038 CANT1 3'UTR;3'UTR;3'UTR chr17:76989642-76990039 N_Shore cg11427177 -0.3187 0.0463 0.0179 0.0229 CAPN3 TSS1500;Body;TSS1500;Body;Body;TSS1500 cg03704061 -0.2968 0.0342 0.0018 0.0325 CAPN9 1stExon;1stExon cg10826045 0.9062 -0.0347 0.0118 0.0132 CAPNS1 5'UTR;5'UTR chr19:36630420-36631142 S_Shore cg25106791 -0.4823 0.0482 0.0224 0.0030 CARD11 Body cg02342906 1.2364 -0.0946 0.0222 0.0190 CASZ1 Body;Body cg08484992 0.4872 -0.0747 0.0272 0.0481 CBFA2T3 5'UTR;Body chr16:88975850-88976169 S_Shore cg05004142 0.6524 -0.0368 0.0091 0.0331 CCDC102A Body chr16:57562451-57563325 Island cg13379763 -0.7261 0.0730 0.0339 0.0237 CCDC108 Body cg05881753 0.6594 -0.0452 0.0246 0.0486 CCDC135 Body chr16:57759991-57760243 Island cg03789597 -0.5144 0.0549 0.0016 0.0172 CCDC57 Body cg26521278 -0.2950 0.0335 0.0049 0.0111 CCDC60 TSS1500 chr12:119772353-119772594 N_Shore cg16313230 0.4626 -0.0353 0.0124 0.0231 CCDC87 1stExon chr11:66360097-66360834 N_Shelf cg16750914 0.7173 -0.0326 0.0335 0.0346 CCDC88A 5'UTR;1stExon;1stExon;5'UTR chr2:55646621-55647329 Island cg20451705 0.2823 -0.0382 0.0339 0.0254 CCDC88C Body cg15374898 -0.6220 0.0839 0.0160 0.0314 CCHCR1 Body;Body;Body chr6:31125894-31126561 N_Shelf cg16415785 0.9317 -0.0315 0.0068 0.0277 CCK 5'UTR chr3:42304944-42305311 Island cg00803692 0.5982 -0.0466 0.0110 0.0211 CCR5 TSS200;TSS200 cg01477015 0.7248 -0.0309 0.0181 0.0161 CD19 Body chr16:28948000-28948450 Island cg07980671 0.5076 -0.0305 0.0015 0.0122 CD2AP Body cg21697512 0.4453 -0.0396 0.0085 0.0142 CD34 Body;Body chr1:208084098-208084513 N_Shelf cg14479884 0.6425 -0.0679 0.0494 0.0452 CD36 5'UTR;1stExon;5'UTR;1stExon;5'UTR cg02768785 -0.2987 0.0439 0.0345 0.0445 CD3EAP 3'UTR;Body;Body chr19:45909062-45910124 S_Shelf

cg01517776 0.6350 -0.0431 0.0402 0.0249 CD81 Body chr11:2417650-2417993 Island cg09838701 0.8003 -0.0544 0.0150 0.0352 CD86 3'UTR;3'UTR cg06507434 -0.3698 0.0416 0.0206 0.0037 CDC42BPG Body chr11:64596975-64597519 Island cg15188688 -0.2350 0.0309 0.0170 0.0028 CDC45L Body chr22:19466308-19467811 S_Shore cg01750200 0.9705 -0.0475 0.0183 0.0396 CDH13 Body cg07895504 -0.3877 0.0719 0.0488 0.0472 CDH22 Body chr20:44806599-44806875 S_Shore cg05140231 -0.2868 0.0396 0.0072 0.0050 CDH4 Body chr20:59965576-59965790 Island cg04123347 0.8687 -0.1370 0.0021 0.0335 CDK16 Body;5'UTR;TSS200 chrX:47077163-47078637 S_Shelf cg10231862 -0.5337 0.0364 0.0139 0.0138 CDKAL1 Body cg16147336 1.4222 -0.0443 0.0358 0.0463 CDKN2C 5'UTR;TSS1500;1stExon chr1:51433762-51435505 Island cg26867821 -0.5894 0.0339 0.0162 0.0077 CDV3 TSS200;TSS200;TSS1500 chr3:133292203-133292908 Island cg21494337 1.2992 -0.0317 0.0199 0.0427 CENPO TSS1500;Body chr2:25015879-25016627 N_Shore cg11639001 0.9934 -0.0715 0.0400 0.0049 CEP164 TSS1500 chr11:117198423-117198950 N_Shore cg24865482 0.8755 -0.0569 0.0034 0.0222 CEP350 Body cg08620313 -1.0126 0.0666 0.0080 0.0326 CES1 TSS1500;TSS1500;TSS1500 chr16:55866647-55866998 S_Shore cg02447462 -0.6518 0.0531 0.0017 0.0181 CFD Body chr19:860517-862123 Island cg21232015 -0.8342 0.0546 0.0385 0.0435 CHFR Body;Body;Body;Body;Body cg02168925 0.6965 -0.0784 0.0041 0.0071 CHM Body;3'UTR cg03062865 0.4232 -0.0486 0.0090 0.0137 CHMP1A Body;Body chr16:89723192-89724636 N_Shelf cg13448968 -1.5292 0.1082 0.0134 0.0410 CHPF Body chr2:220406363-220406840 Island cg05957190 0.3902 -0.0531 0.0262 0.0132 CHST11 Body cg07399369 1.0263 -0.0424 0.0005 0.0070 CHST2 TSS1500 chr3:142837885-142840838 Island cg12395205 1.3236 -0.0323 0.0061 0.0475 CIDEA Body;TSS200 chr18:12254147-12255089 Island cg10669058 -0.4197 0.0517 0.0482 0.0316 CILP2 TSS1500 chr19:19648134-19649390 Island cg27492942 0.5990 -0.0992 0.0100 0.0203 CISD3 TSS1500;3'UTR chr17:36886108-36886525 N_Shore cg02690554 -0.6351 0.0401 0.0236 0.0125 CITED1 TSS1500;TSS1500 chrX:71524832-71527299 S_Shore cg09125723 -0.3856 0.0339 0.0069 0.0330 CLASP1 3'UTR;3'UTR;3'UTR cg14617014 0.4976 -0.0384 0.0357 0.0151 CLCA3P Body cg11108456 0.4786 -0.0480 0.0125 0.0449 CLCN5 TSS1500;TSS1500 chrX:49687027-49687993 N_Shore cg02882493 0.8957 -0.0686 0.0315 0.0370 CLCN7 Body;Body chr16:1507355-1507653 S_Shore cg08199758 -0.6810 0.0497 0.0016 0.0132 CLDN9 TSS200 chr16:3063679-3063981 N_Shore cg01130127 1.4244 -0.1219 0.0057 0.0133 CLEC11A 3'UTR chr19:51227661-51228883 Island cg13026137 -0.2788 0.0300 0.0094 0.0152 CLIC1 Body chr6:31695894-31698245 S_Shelf

cg16006141 0.7105 -0.0382 0.0081 0.0246 CLIC4 3'UTR cg15882878 1.2345 -0.2110 0.0294 0.0452 CLSTN3 TSS1500;TSS200 cg21088983 0.6363 -0.0645 0.0407 0.0381 CLVS1 TSS200 cg27344162 0.5610 -0.0441 0.0492 0.0290 CMIP Body;Body cg15630394 0.9178 -0.0982 0.0206 0.0222 CMKLR1 TSS1500;5'UTR;5'UTR;5'UTR cg09655403 0.3291 -0.0397 0.0494 0.0422 CMYA5 TSS200 cg02840828 -0.1881 0.0376 0.0274 0.0257 CNDP1 TSS200 cg26686932 0.6522 -0.0309 0.0035 0.0302 CNGA1 5'UTR;5'UTR cg13859943 0.9257 -0.0988 0.0048 0.0330 CNKSR2 Body;Body chrX:21674018-21677066 N_Shelf cg09882550 -0.2747 0.0344 0.0215 0.0173 CNOT6 TSS1500 chr5:179921201-179922179 N_Shore cg09479341 0.4612 -0.0712 0.0021 0.0269 CNP Body chr17:40119811-40120047 Island cg26456563 0.7925 -0.0566 0.0228 0.0032 CNTD2 3'UTR chr19:40728235-40728618 Island cg11635155 0.7379 -0.0405 0.0408 0.0484 CNTN3 Body cg11395306 0.5278 -0.0373 0.0374 0.0232 CNTN5 5'UTR;5'UTR cg27405644 1.0143 -0.0604 0.0159 0.0022 CNTNAP1 TSS200;TSS1500 chr17:40834791-40835098 N_Shore cg11070260 1.1662 -0.0661 0.0258 0.0485 COASY TSS200;TSS200;TSS200;TSS200;TSS200 chr17:40714087-40715282 N_Shore cg18084609 -0.4475 0.0678 0.0373 0.0319 COCH Body;Body chr14:31343355-31344757 S_Shore cg19628686 1.5536 -0.1465 0.0225 0.0257 COL11A2 Body;Body;Body;Body chr6:33159991-33160263 N_Shore cg17453252 -0.2044 0.0378 0.0077 0.0300 COL4A2 Body chr13:110965774-110966223 N_Shore cg18995182 1.7531 -0.1323 0.0290 0.0285 COL4A5 TSS1500;TSS1500;TSS1500;TSS1500;TSS200 cg26947474 0.6248 -0.0636 0.0208 0.0434 COL4A6 Body;Body cg03384959 -0.6739 0.0611 0.0203 0.0209 COL6A3 Body;Body;Body;Body;Body cg00762069 0.5215 -0.0331 0.0149 0.0125 COL6A4P2 Body chr3:129982745-129983090 S_Shelf cg20682720 0.5652 -0.0403 0.0088 0.0421 COL9A1 3'UTR;3'UTR cg18753958 -0.8709 0.1238 0.0041 0.0027 COL9A3 TSS1500 chr20:61447685-61448891 N_Shore cg22974630 0.7299 -0.0873 0.0493 0.0077 COPZ1 Body cg08822732 0.5727 -0.0378 0.0208 0.0232 COQ3 Body chr6:99841661-99842146 N_Shelf cg07053699 0.9466 -0.1034 0.0045 0.0354 COX6A2 TSS1500 chr16:31438891-31439682 S_Shore cg26230601 -0.5780 0.0467 0.0223 0.0041 CPN2 TSS200 cg08565632 0.6168 -0.0712 0.0247 0.0253 CPNE7 Body;Body chr16:89650792-89651058 Island cg06891533 -0.9945 0.0730 0.0075 0.0089 CPSF1 Body chr8:145622979-145623325 Island cg23026906 -0.1747 0.0301 0.0244 0.0405 CR1L Body chr1:207818389-207818952 S_Shore cg03734660 0.7088 -0.0350 0.0031 0.0295 CRABP2 5'UTR;1stExon chr1:156674858-156676654 Island

cg05151055 0.6015 -0.0437 0.0148 0.0318 CREBBP Body;Body chr16:3776134-3776548 S_Shore cg16424311 0.6538 -0.0579 0.0230 0.0021 CRISP3 Body cg16106368 -1.0266 0.0327 0.0123 0.0065 CRMP1 Body;TSS200 chr4:5889203-5890645 Island cg07472953 1.5954 -0.0905 0.0289 0.0442 CSF3 TSS1500;TSS1500;TSS1500 cg13619522 -1.1202 0.2022 0.0029 0.0117 CSK 3'UTR;3'UTR chr15:75095349-75095560 N_Shore cg19884629 0.7380 -0.0390 0.0130 0.0470 CSMD1 Body cg21917532 0.9683 -0.0644 0.0037 0.0318 CSMD3 Body;Body chr8:114444826-114445085 S_Shelf cg24598020 1.1372 -0.0970 0.0237 0.0366 CSNK1A1 Body;Body chr5:148930249-148931244 N_Shore cg20281729 0.5420 -0.0432 0.0114 0.0402 CSNK2B Body chr6:31632815-31634093 S_Shore cg24665612 0.7092 -0.0315 0.0333 0.0241 CT45A6 TSS1500 cg04653469 -0.5463 0.0340 0.0103 0.0020 CTBP1 Body;Body chr4:1233872-1234420 N_Shore cg19923114 0.5984 -0.0385 0.0431 0.0080 CTNNA2 Body;Body cg14453321 0.4853 -0.0416 0.0203 0.0031 CTPS2 Body;Body;TSS200;Body cg20858526 -0.3838 0.0518 0.0023 0.0001 CTRC Body cg18738367 -0.2875 0.0462 0.0249 0.0107 CTSH TSS1500;TSS1500 chr15:79237040-79237571 S_Shore cg24873880 0.5315 -0.0364 0.0355 0.0092 CUGBP2 Body;Body cg13300744 -0.5500 0.0442 0.0074 0.0342 CUX2 Body cg01257799 -0.3815 0.0554 0.0354 0.0302 CXCR5 TSS1500 cg10064814 -0.2947 0.0560 0.0406 0.0140 CXorf40B Body cg13929206 -0.2332 0.0397 0.0331 0.0498 CXorf58 5'UTR;5'UTR;TSS1500;TSS1500 chrX:23925590-23926315 S_Shore cg14871225 -1.1558 0.0743 0.0369 0.0370 CXXC5 5'UTR chr5:139040819-139041028 Island cg25917853 0.7756 -0.0341 0.0189 0.0310 CYB5R4 TSS1500 chr6:84569263-84569619 N_Shore cg02723913 0.7020 -0.0489 0.0044 0.0177 CYFIP1 Body;Body cg23462242 -0.6709 0.0559 0.0275 0.0453 CYFIP2 TSS200;5'UTR;5'UTR chr5:156692812-156693749 S_Shelf cg16445268 -0.5523 0.0810 0.0022 0.0135 CYP26A1 Body;Body chr10:94833272-94835256 S_Shore cg06122697 -0.6456 0.0618 0.0069 0.0101 CYP26B1 Body cg07750118 -0.6192 0.0324 0.0409 0.0182 CYP2F1 Body chr19:41630485-41630794 S_Shore cg10896827 -0.4254 0.0403 0.0167 0.0090 CYP4V2 3'UTR cg26040060 0.4408 -0.0312 0.0285 0.0173 CYTH1 Body;Body cg25044524 0.4638 -0.0655 0.0271 0.0368 CYTSB Body;TSS1500;TSS1500;Body chr17:20059028-20060060 N_Shore cg14190522 -0.6965 0.0881 0.0019 0.0215 DAB2IP Body cg06437799 0.4529 -0.0643 0.0262 0.0234 DAP3 5'UTR;5'UTR;TSS1500;TSS1500 chr1:155657832-155659125 S_Shore cg09357934 -0.2383 0.0320 0.0008 0.0106 DAPL1 1stExon

cg24513883 -0.8427 0.0406 0.0153 0.0155 DAXX 5'UTR;Body;Body;5'UTR chr6:33290370-33291087 Island cg09439260 0.8296 -0.0376 0.0234 0.0462 DAZL Body chr3:16645948-16646259 N_Shore cg26900724 0.5203 -0.0359 0.0326 0.0141 DBN1 TSS1500 cg08442088 -0.6065 0.0451 0.0207 0.0417 DBNL Body;Body;Body chr7:44084106-44084747 S_Shore cg23004409 -0.5176 0.0807 0.0031 0.0455 DCAKD 5'UTR;5'UTR chr17:43128789-43129038 N_Shore cg18969798 0.4625 -0.0349 0.0163 0.0029 DCLK2 Body;Body cg21596858 0.4046 -0.0415 0.0075 0.0060 DCST1 Body;TSS1500;Body cg02999755 0.8725 -0.0505 0.0485 0.0333 DCUN1D5 TSS1500 chr11:102962274-102963049 S_Shore cg14293129 0.4656 -0.0776 0.0222 0.0441 DDAH2 Body chr6:31695894-31698245 Island cg23587005 0.8881 -0.0395 0.0211 0.0003 DDX12 TSS200 chr12:9600415-9601259 Island cg26055054 0.5962 -0.0376 0.0077 0.0013 DDX26B TSS1500 chrX:134655102-134655750 N_Shore cg07089660 0.5888 -0.0619 0.0038 0.0016 DEFA4 5'UTR cg12279138 -0.2794 0.0346 0.0076 0.0424 DEGS1 TSS1500;TSS1500 chr1:224370585-224371755 N_Shore cg26141291 -0.4004 0.0567 0.0079 0.0090 DENND3 Body cg25496104 -0.5882 0.0438 0.0411 0.0381 DERA 3'UTR cg04206724 -0.3021 0.0433 0.0045 0.0443 DEXI 3'UTR cg18249027 -0.4738 0.0334 0.0043 0.0302 DGKI Body chr7:137531125-137532382 N_Shelf cg10519492 0.6693 -0.0326 0.0036 0.0063 DHX16 TSS200;TSS200 chr6:30640431-30640853 S_Shore cg10625504 0.5283 -0.0380 0.0022 0.0216 DHX30 5'UTR;5'UTR chr3:47844121-47845155 S_Shelf cg08368055 -0.2574 0.0414 0.0024 0.0003 DHX38 5'UTR;TSS1500 chr16:72127129-72127341 S_Shore cg16762195 0.8409 -0.0321 0.0037 0.0018 DHX58 TSS200 cg24949196 -0.6067 0.0624 0.0239 0.0349 DIAPH3 3'UTR TSS1500;TSS1500;TSS1500;TSS1500;TSS150 cg25539589 0.8094 -0.0584 0.0095 0.0179 DIP2A 0;TSS1500;TSS1500 chr21:47878070-47879576 N_Shore cg02061711 1.0511 -0.1619 0.0103 0.0014 DIP2C Body cg09307104 0.9141 -0.0340 0.0213 0.0127 DLG3 1stExon chrX:69665102-69665355 Island cg23566401 0.5980 -0.0504 0.0147 0.0294 DLG4 1stExon;Body;5'UTR chr17:7123038-7123718 N_Shelf cg04119909 -0.5718 0.0863 0.0009 0.0130 DLG5 Body cg27602828 0.5440 -0.0503 0.0346 0.0385 DLGAP1 TSS200;Body cg16268546 0.7704 -0.0453 0.0398 0.0100 DLGAP2 3'UTR chr8:1649439-1649759 S_Shore cg11951427 0.4359 -0.0391 0.0015 0.0240 DLGAP3 Body chr1:35350878-35351854 S_Shore cg12308746 0.4317 -0.0442 0.0283 0.0004 DLX1 Body;Body chr2:172952809-172953160 N_Shore cg27136740 0.5709 -0.0309 0.0375 0.0210 DLX2 Body chr2:172964762-172967857 Island

cg18544329 0.5835 -0.0319 0.0300 0.0068 DLX5 TSS200 chr7:96653467-96654199 Island cg04599026 0.5745 -0.0337 0.0273 0.0192 DLX6AS Body;TSS1500 chr7:96634622-96634915 Island cg14457908 -0.4542 0.0418 0.0159 0.0263 DMP1 3'UTR;3'UTR cg12743974 0.4615 -0.0324 0.0176 0.0319 DNAH11 Body cg06951011 -0.8361 0.0445 0.0331 0.0456 DNAH3 Body cg03062166 -1.0319 0.0685 0.0001 0.0092 DNAI1 TSS200;TSS200 chr9:34457375-34458892 Island cg14645317 -1.0124 0.0573 0.0494 0.0358 DNAJB5 TSS1500;TSS1500;TSS1500 chr9:34989555-34989875 N_Shore cg06635715 0.8567 -0.0404 0.0168 0.0370 DNAJC1 Body cg17689490 0.7480 -0.0378 0.0033 0.0028 DOCK1 Body;Body cg20036377 0.5812 -0.0373 0.0373 0.0129 DOCK5 Body cg05090137 0.7426 -0.0496 0.0354 0.0408 DOK7 Body;Body chr4:3475058-3475360 N_Shelf cg13259605 0.8371 -0.0433 0.0027 0.0250 DPM2 5'UTR;1stExon chr9:130699759-130700266 Island cg12666279 -0.6557 0.0312 0.0438 0.0375 DPP10 TSS1500;Body chr2:115918737-115920765 Island cg26441097 -0.7171 0.0939 0.0024 0.0120 DPPA4 Body cg19477942 -0.8226 0.0426 0.0067 0.0457 DSCAM Body cg03761952 0.6758 -0.0442 0.0054 0.0083 DSG4 1stExon;1stExon;5'UTR;5'UTR cg07991100 0.7039 -0.0497 0.0305 0.0324 DTHD1 TSS200 cg13862271 0.6628 -0.0325 0.0317 0.0306 DTX4 Body cg18088242 0.9096 -0.0341 0.0358 0.0032 DUOX1 5'UTR;TSS1500;5'UTR chr15:45421236-45422394 Island cg05371885 1.4052 -0.0770 0.0015 0.0061 DUSP22 3'UTR cg02107163 0.5856 -0.0322 0.0483 0.0429 DUSP28 5'UTR;1stExon chr2:241499582-241500785 Island cg15089090 0.7785 -0.0324 0.0128 0.0472 DUSP7 Body chr3:52089652-52090845 N_Shore cg05085049 0.6765 -0.0378 0.0469 0.0461 DUSP9 5'UTR chrX:152909502-152910069 Island cg16398957 -0.4355 0.0304 0.0290 0.0217 DYNC1H1 Body cg01238502 0.6185 -0.0323 0.0405 0.0123 DYNLL1 Body;Body;Body chr12:120933649-120934713 S_Shore cg07056057 -0.4743 0.0354 0.0497 0.0366 DYNLL2 TSS1500 chr17:56160754-56161494 N_Shore cg07070273 0.7601 -0.0367 0.0103 0.0382 DYNLRB2 3'UTR cg22079271 -0.5269 0.0339 0.0034 0.0189 ECEL1 Body chr2:233350278-233352974 N_Shelf cg20052010 0.7312 -0.0336 0.0160 0.0436 EFEMP1 Body;Body;Body cg14874936 0.4361 -0.0317 0.0314 0.0377 EFNA5 Body cg01107476 0.5650 -0.0359 0.0124 0.0188 EGR1 3'UTR chr5:137803095-137803333 S_Shore cg16391101 -0.7469 0.0468 0.0004 0.0021 EHMT1 3'UTR chr9:140728478-140729896 Island cg21190306 -0.3968 0.0379 0.0260 0.0122 EHMT2 Body;Body chr6:31864897-31865419 N_Shore

cg06753055 0.4888 -0.0328 0.0044 0.0291 EIF2AK4 Body chr15:40226210-40226631 S_Shelf cg07752613 -0.3632 0.0342 0.0465 0.0339 EIF2C2 Body;Body cg06206086 -1.0724 0.0936 0.0075 0.0323 EIF2C3 5'UTR;Body cg20110780 1.9427 -0.1314 0.0003 0.0091 EIF3E TSS200 chr8:109260526-109261127 Island cg08456754 -0.2829 0.0305 0.0423 0.0004 EIF3G Body chr19:10226164-10226702 Island cg14153321 0.6299 -0.0334 0.0148 0.0157 EIF3L Body chr22:38245341-38245681 S_Shore cg17324095 -0.6638 0.0988 0.0093 0.0266 ELFN1 5'UTR chr7:1784027-1786934 N_Shore cg19781013 0.6536 -0.0314 0.0005 0.0039 ELP3 TSS1500 chr8:27950470-27950868 N_Shore cg06350544 0.6076 -0.0788 0.0206 0.0457 EMP3 Body chr19:48833394-48833720 Island cg08050360 1.3142 -0.1256 0.0008 0.0145 EN1 TSS200 chr2:119606038-119606313 N_Shore cg25975818 1.1219 -0.0668 0.0042 0.0144 ENPP7 TSS1500 cg02103653 0.6645 -0.0386 0.0403 0.0476 EPB41L4A Body cg15882566 -0.3383 0.0541 0.0390 0.0087 EPB42 Body;Body cg13587495 0.3801 -0.0461 0.0026 0.0379 EPHA3 3'UTR;Body 5'UTR;TSS1500;TSS1500;TSS1500;TSS200;1s cg23658326 1.7155 -0.0594 0.0104 0.0161 EPM2AIP1 tExon chr3:37034228-37035356 Island cg10503037 0.8090 -0.0468 0.0305 0.0108 EPRS Body chr1:220219416-220219824 N_Shore cg17875320 0.3966 -0.0362 0.0445 0.0264 EPS8L3 TSS1500;TSS1500;TSS1500 cg05616959 0.8241 -0.0568 0.0239 0.0344 ERC2 Body cg08678898 0.3999 -0.0352 0.0355 0.0157 ERF Body chr19:42757495-42759475 Island cg26952936 -0.2280 0.0512 0.0242 0.0362 ERN2 TSS200 chr16:23724270-23724775 S_Shore cg25015465 -0.5576 0.0380 0.0349 0.0283 ESRRB Body chr14:76957865-76958074 Island cg01432520 0.9934 -0.0820 0.0288 0.0380 ESRRG 5'UTR;5'UTR;5'UTR cg21535580 0.2286 -0.0455 0.0263 0.0316 ETNK2 TSS1500 chr1:204120398-204121109 S_Shore cg22387575 -0.4479 0.0410 0.0099 0.0376 ETV7 3'UTR cg00196414 1.2640 -0.0828 0.0004 0.0142 EVX2 Body chr2:176944087-176948446 Island cg14495958 -0.2996 0.0402 0.0371 0.0483 EXD3 5'UTR chr9:140301338-140301826 N_Shore cg01890435 0.4336 -0.0487 0.0074 0.0489 EXOC3 TSS1500;3'UTR;1stExon chr5:442820-443604 N_Shore cg03526652 1.0768 -0.0591 0.0207 0.0418 EXOC6B Body cg17800649 -0.4644 0.0307 0.0003 0.0128 EXOSC10 Body;Body chr1:11159387-11160136 Island cg04066177 0.8132 -0.0662 0.0060 0.0421 FABP9 TSS1500 cg06096805 0.4114 -0.0393 0.0394 0.0384 FAM102A TSS1500 chr9:130742515-130743486 S_Shore cg18931398 0.8932 -0.0651 0.0198 0.0211 FAM102B Body

cg00811565 0.4583 -0.0503 0.0314 0.0197 FAM159B TSS1500 chr5:63986189-63986974 N_Shore cg21313962 -0.7761 0.0366 0.0339 0.0173 FAM160B2 Body cg12094006 -0.9538 0.0401 0.0011 0.0271 FAM167A TSS200 chr8:11323779-11324697 Island cg03502562 -0.8317 0.0742 0.0011 0.0190 FAM175B Body chr10:126490161-126490934 S_Shore cg00088507 -0.7819 0.0379 0.0049 0.0410 FAM189A1 Body cg19045983 -0.5252 0.0317 0.0021 0.0201 FAM18B2 Body;Body chr17:15466359-15466843 Island cg17769199 0.4191 -0.0362 0.0425 0.0090 FAM197Y2 TSS1500 chrY:9193597-9194776 N_Shore cg11020853 -0.2010 0.0428 0.0177 0.0341 FAM198A TSS200 chr3:43020702-43021354 N_Shore cg04382374 0.3220 -0.0421 0.0133 0.0349 FAM19A5 Body;Body cg02603662 -0.8501 0.0568 0.0002 0.0070 FAM38A Body chr16:88803802-88804112 N_Shelf cg22942908 0.3628 -0.0545 0.0337 0.0176 FAM40A Body chr1:110577199-110577942 S_Shore cg07765262 0.5101 -0.0691 0.0363 0.0237 FAM53A Body chr4:1645886-1646324 Island cg08901593 0.3299 -0.0500 0.0487 0.0427 FAM5B Body cg20497803 0.8733 -0.0437 0.0377 0.0487 FAM83B 5'UTR chr6:54711153-54712033 Island cg17199320 -0.8891 0.0372 0.0095 0.0030 FAM89A TSS1500 chr1:231176785-231177009 Island cg22172517 0.9077 -0.0536 0.0008 0.0165 FAM9A TSS1500;TSS1500 chrX:8769177-8769559 S_Shore cg10492417 -0.3951 0.0350 0.0013 0.0232 FANCA Body cg14222432 0.9434 -0.0545 0.0127 0.0095 FAR2 TSS200 cg03673225 0.7496 -0.0517 0.0038 0.0294 FARP1 Body cg08193821 0.5778 -0.0401 0.0382 0.0050 FARS2 Body cg14797580 0.6479 -0.0486 0.0258 0.0062 FASN Body chr17:80054171-80054392 N_Shore cg22011804 0.3161 -0.0436 0.0416 0.0201 FASTK TSS1500;Body;Body;TSS1500 chr7:150777607-150780879 Island cg26031678 -0.2591 0.0403 0.0020 0.0150 FBLN2 Body;Body;Body chr3:13611923-13612435 S_Shore cg21011649 0.2407 -0.0360 0.0416 0.0072 FBN1 Body cg03621470 0.9013 -0.0696 0.0087 0.0459 FBRSL1 Body chr12:133136392-133137480 Island cg24327472 0.8405 -0.0554 0.0181 0.0348 FBXO16 TSS1500 chr8:28351456-28352560 N_Shelf cg15746187 0.3145 -0.0520 0.0075 0.0046 FBXO2 Body;TSS1500 chr1:11714217-11715304 N_Shore cg06109876 -0.4136 0.0392 0.0434 0.0047 FBXO32 TSS1500;Body cg04853218 -0.2913 0.0429 0.0001 0.0044 FBXO34 5'UTR;5'UTR cg20107840 0.6957 -0.0317 0.0047 0.0375 FBXO45 3'UTR cg00479908 0.4336 -0.0353 0.0188 0.0141 FBXO46 Body chr19:46214961-46216180 Island cg26740942 0.5522 -0.0430 0.0042 0.0394 FBXO47 TSS200 cg24783510 0.5644 -0.0582 0.0113 0.0193 FCHO1 5'UTR;TSS200;TSS200;5'UTR chr19:17858371-17858891 S_Shelf

cg08786003 0.7873 -0.0590 0.0118 0.0445 FCRL3 TSS200 cg12906303 0.4831 -0.0325 0.0497 0.0228 FEZ1 Body cg11902408 -0.1791 0.0324 0.0033 0.0081 FGD5 TSS1500 cg20684197 0.5212 -0.0428 0.0064 0.0474 FGF1 5'UTR;5'UTR;TSS1500;TSS1500;Body;Body cg02302670 -0.5599 0.0558 0.0384 0.0164 FGF17 Body chr8:21905461-21905757 N_Shore cg13422817 0.4028 -0.0316 0.0444 0.0267 FGF6 Body chr12:4554405-4554624 N_Shelf cg16248277 -0.4878 0.0494 0.0085 0.0298 FGF8 TSS1500;TSS1500;TSS1500;TSS1500 chr10:103535636-103536505 Island cg02826685 0.5534 -0.0343 0.0139 0.0239 FGFRL1 Body;Body;Body chr4:1005930-1006282 S_Shelf cg10055277 -0.1921 0.0396 0.0009 0.0055 FHAD1 Body cg23737061 0.7965 -0.0882 0.0212 0.0260 FHIT Body;Body cg06626224 0.5662 -0.0337 0.0064 0.0165 FIZ1 TSS1500;TSS1500 chr19:56111498-56112063 Island cg23801475 -1.2387 0.0781 0.0006 0.0081 FKBP2 5'UTR;TSS200;5'UTR chr11:64008283-64009487 Island cg11609631 0.5170 -0.0389 0.0037 0.0283 FLI1 3'UTR;3'UTR chr11:128680332-128680543 S_Shelf cg26829758 -0.7416 0.0650 0.0305 0.0255 FLJ22536 Body cg26600181 1.1372 -0.0834 0.0074 0.0133 FLJ36777 TSS200 cg06534376 -0.6117 0.0604 0.0206 0.0387 FLOT1 Body chr6:30710307-30712440 N_Shore cg13263274 0.6007 -0.0433 0.0174 0.0466 FLRT1 Body;Body chr11:63885581-63885788 Island cg06485114 1.2022 -0.0875 0.0045 0.0122 FLT4 Body;Body chr5:180045789-180048897 Island cg15007623 -0.5005 0.0327 0.0274 0.0326 FMN2 Body chr1:240370859-240371526 S_Shore cg26204803 -0.3624 0.0349 0.0051 0.0180 FMNL2 Body cg09425262 -0.7328 0.0418 0.0033 0.0313 FMR1NB TSS200 chrX:147062671-147062917 Island cg15367592 -0.3817 0.0485 0.0232 0.0092 FOLR3 TSS1500 cg24397007 -0.7294 0.0818 0.0241 0.0016 FOSL2 Body chr2:28612964-28616748 S_Shelf cg09200221 0.8291 -0.0762 0.0142 0.0082 FOXK1 Body cg11779900 0.5542 -0.0302 0.0378 0.0449 FOXK2 Body cg16384774 -0.8127 0.0427 0.0344 0.0023 FOXN3 3'UTR;3'UTR chr14:89628885-89629199 N_Shore cg04784898 -0.2553 0.0506 0.0281 0.0495 FOXN4 Body chr12:109729572-109729826 N_Shelf cg13680696 0.9974 -0.0487 0.0236 0.0020 FRAT2 3'UTR;1stExon chr10:99093406-99094955 N_Shore cg27180636 0.5014 -0.0570 0.0480 0.0051 FRG2C 3'UTR chr3:75718116-75719159 N_Shelf cg15803756 -0.6519 0.0339 0.0067 0.0302 FRMD4A Body chr10:13933482-13934184 N_Shore cg22828061 -0.5759 0.0543 0.0327 0.0375 FUT8 TSS1500;TSS1500 chr14:65878486-65880370 N_Shelf cg17000199 0.5807 -0.0774 0.0171 0.0194 FUT9 5'UTR chr6:96463869-96464136 S_Shore cg07158339 0.3780 -0.0704 0.0078 0.0054 FXN TSS1500;TSS1500;TSS1500 chr9:71650646-71651176 N_Shore

cg07780528 0.7121 -0.0656 0.0313 0.0369 FXYD1 5'UTR;TSS200 chr19:35632356-35632572 N_Shelf cg25424600 0.7746 -0.0357 0.0022 0.0123 FYB 3'UTR;3'UTR cg26129669 -0.3058 0.0643 0.0027 0.0049 GABBR1 Body;Body;Body chr6:29595298-29595795 N_Shore cg21242208 0.6550 -0.0675 0.0268 0.0220 GABRB2 Body;Body chr5:160974692-160975384 N_Shelf cg00206332 0.2065 -0.0325 0.0149 0.0110 GABRE Body chrX:151142680-151143555 N_Shore cg25295063 1.0615 -0.0495 0.0111 0.0449 GADD45B TSS1500 chr19:2474610-2476828 Island cg21452538 0.7787 -0.0379 0.0015 0.0304 GAK Body chr4:870695-870969 Island cg00988350 -0.4635 0.0661 0.0335 0.0159 GALE 5'UTR;1stExon;5'UTR;5'UTR chr1:24126799-24127549 N_Shore cg15448736 0.9450 -0.0500 0.0094 0.0101 GALNT9 Body;Body chr12:132853943-132854190 N_Shore cg11734841 0.6059 -0.0494 0.0281 0.0291 GAS7 Body cg06839377 0.3856 -0.0537 0.0008 0.0032 GBF1 TSS1500 chr10:104005139-104005592 N_Shore cg16476432 -0.2459 0.0365 0.0134 0.0051 GCK TSS1500 cg03309176 1.1205 -0.1291 0.0046 0.0157 GEFT TSS1500;TSS200 chr12:58003880-58004249 N_Shore cg17896463 0.3545 -0.0324 0.0417 0.0191 GEMIN7 TSS1500;TSS1500;TSS1500 chr19:45582337-45582936 N_Shore cg13085470 0.5439 -0.0537 0.0005 0.0043 GFER TSS1500 chr16:2033492-2034800 Island cg14633783 0.8717 -0.0308 0.0202 0.0499 GFRA2 1stExon;5'UTR;1stExon;5'UTR;1stExon;5'UTR chr8:21644908-21647845 Island cg11828203 -0.1531 0.0361 0.0115 0.0499 GHRHR Body;Body cg18538812 -0.1769 0.0306 0.0324 0.0052 GIF TSS1500 cg16905207 0.4203 -0.0414 0.0013 0.0276 GIPC1 Body;5'UTR;5'UTR;Body;5'UTR;Body chr19:14591032-14591308 S_Shelf cg06088858 0.4040 -0.0468 0.0105 0.0198 GJB4 TSS1500 chr1:35227028-35227276 N_Shelf cg09157127 0.6996 -0.0600 0.0205 0.0181 GKN1 TSS1500 cg14864999 0.9172 -0.0619 0.0217 0.0099 GLCE 3'UTR cg13588086 0.5163 -0.0670 0.0040 0.0122 GLDC Body chr9:6645080-6645975 N_Shore cg16248554 -0.5261 0.0491 0.0006 0.0089 GLI2 Body cg04304216 0.7507 -0.0404 0.0057 0.0068 GLS Body cg15474999 0.7616 -0.0653 0.0146 0.0341 GLT25D1 Body chr19:17666192-17666978 S_Shelf cg14585174 0.6889 -0.0478 0.0169 0.0179 GLT6D1 3'UTR cg19248242 0.7873 -0.0469 0.0225 0.0109 GNA11 Body chr19:3094671-3095055 Island cg14219599 0.9286 -0.0303 0.0149 0.0025 GNL1 Body;TSS1500;TSS1500 chr6:30523286-30523519 Island cg09817993 1.3949 -0.1082 0.0122 0.0010 GNL3 TSS1500;5'UTR;TSS1500;TSS1500 chr3:52719934-52720335 N_Shore cg06242751 0.8531 -0.0538 0.0229 0.0023 GOLGA3 Body chr12:133349663-133349998 S_Shore cg01095157 -0.4440 0.0662 0.0156 0.0284 GORASP2 TSS1500 chr2:171785474-171786399 N_Shore cg03952248 0.4141 -0.0629 0.0160 0.0399 GPATCH3 TSS1500 chr1:27226492-27227009 S_Shore

cg01390346 0.6503 -0.0493 0.0048 0.0014 GPBP1 TSS200;TSS200 chr5:56469018-56470521 Island cg22998749 0.6116 -0.0333 0.0033 0.0180 GPC6 Body cg20423693 0.3421 -0.0417 0.0367 0.0488 GPM6A 5'UTR;Body cg01061553 -1.1684 0.0824 0.0027 0.0078 GPN3 Body;Body;Body chr12:110887861-110888245 S_Shelf cg05220599 0.4576 -0.0521 0.0049 0.0014 GPR123 3'UTR chr10:134944511-134944792 Island cg23843100 -0.5847 0.0368 0.0020 0.0054 GPR126 Body;Body;Body;Body chr6:142622583-142623453 S_Shelf cg14359680 -0.4897 0.0339 0.0292 0.0091 GPR132 TSS1500 cg08943696 -0.5908 0.0450 0.0164 0.0248 GPR133 TSS1500 cg13074682 0.4920 -0.0345 0.0093 0.0257 GPR176 Body cg01859669 -0.1980 0.0343 0.0014 0.0192 GPR31 TSS200 cg27450557 0.4050 -0.0362 0.0474 0.0011 GPR37L1 TSS1500 cg19254163 0.2160 -0.0408 0.0490 0.0420 GPR44 TSS1500 chr11:60619924-60621111 S_Shelf cg19755435 0.8616 -0.0537 0.0256 0.0151 GPR65 5'UTR cg01768433 0.8892 -0.0602 0.0067 0.0024 GPR98 Body;Body cg14489965 -0.6431 0.0568 0.0006 0.0170 GPSM1 Body;Body chr9:139255523-139256012 N_Shelf cg23788628 1.0126 -0.0521 0.0197 0.0066 GPX5 Body;3'UTR cg20561261 0.3948 -0.0584 0.0106 0.0146 GRB2 3'UTR;3'UTR cg23285393 0.4661 -0.0429 0.0033 0.0330 GREB1 Body chr2:11732841-11733303 S_Shelf cg20306837 1.2169 -0.0595 0.0267 0.0052 GRIA4 Body;Body;Body;Body chr11:105481126-105481422 S_Shore cg06855422 0.6999 -0.0550 0.0426 0.0403 GRID2 Body cg00534626 0.8107 -0.0634 0.0203 0.0018 GRIN2A Body;Body;Body cg11277090 0.2782 -0.0476 0.0360 0.0111 GRIN2C Body chr17:72848166-72848901 N_Shore cg05141026 0.3792 -0.0316 0.0157 0.0221 GRINA 5'UTR;5'UTR chr8:145063919-145065386 Island cg05572003 0.3644 -0.0313 0.0090 0.0056 GRK6 Body;Body;Body chr5:176863062-176863266 S_Shelf cg00986191 0.4864 -0.0629 0.0401 0.0110 GRM6 Body chr5:178421225-178422337 N_Shore cg13054613 0.5964 -0.0616 0.0419 0.0009 GRM7 Body;3'UTR cg14184077 0.5236 -0.0342 0.0081 0.0007 GRXCR1 1stExon cg00671823 -0.3354 0.0642 0.0143 0.0174 GTF3C1 Body chr16:27560979-27561560 N_Shelf cg01285164 0.8500 -0.0348 0.0452 0.0305 GXYLT2 TSS1500 cg07156296 0.6433 -0.0397 0.0123 0.0474 HADH Body chr4:108910770-108911370 Island cg03324101 0.5149 -0.0466 0.0194 0.0083 HAP1 TSS1500;TSS1500;TSS1500 chr17:39889956-39891489 S_Shore cg25315287 1.0509 -0.0413 0.0442 0.0461 HAUS5 TSS200 chr19:36103554-36103804 N_Shore cg26432088 -0.3611 0.0634 0.0071 0.0424 HAVCR1 TSS1500;TSS1500

cg01598642 0.9033 -0.0589 0.0142 0.0348 HBG1 TSS1500 cg10322499 0.9023 -0.0668 0.0037 0.0006 HBXIP TSS1500 chr1:110949892-110950540 S_Shore cg01126821 0.2076 -0.0362 0.0231 0.0225 HCCA2 Body;TSS1500 cg24711407 0.7893 -0.0350 0.0160 0.0473 HCCS TSS1500;TSS1500 chrX:11129276-11129758 N_Shore cg08276565 -0.8559 0.1234 0.0122 0.0086 HCG18 TSS1500;5'UTR;5'UTR;TSS1500 chr6:30294169-30295071 S_Shore cg04875977 -0.5439 0.0856 0.0123 0.0015 HCN2 Body chr19:615691-623505 Island cg05933219 0.7689 -0.0308 0.0214 0.0079 HDAC4 Body chr2:240100625-240100852 N_Shore cg03847432 0.6467 -0.0484 0.0355 0.0246 HECW1 Body cg00510111 0.2569 -0.0301 0.0329 0.0157 HECW2 TSS1500 chr2:197457392-197458522 Island cg09995631 -0.6024 0.0460 0.0104 0.0055 HERC2 Body cg07846755 -0.7511 0.0339 0.0306 0.0023 HES1 TSS1500 chr3:193852241-193852717 Island cg24127874 -0.7272 0.0380 0.0078 0.0155 HES6 TSS1500;TSS1500 chr2:239147592-239149900 Island cg00987513 -0.2591 0.0447 0.0057 0.0278 HFE2 1stExon;5'UTR;5'UTR;1stExon;1stExon;5'UTR;5'UTR;1stExonchr1:145415411-145415708 N_Shelf cg22858008 0.6765 -0.0520 0.0293 0.0369 HGC6.3 1stExon;5'UTR chr6:168377416-168377724 Island cg04413153 -0.4456 0.0468 0.0437 0.0297 HHEX TSS1500 chr10:94448693-94450479 Island cg25703243 1.3548 -0.1622 0.0068 0.0145 HHIP Body chr4:145566242-145567413 S_Shore cg02075822 0.5056 -0.0319 0.0339 0.0136 HIP1 Body chr7:75368062-75369078 N_Shelf cg23478350 -0.5981 0.0402 0.0491 0.0309 HIP1R Body cg01023668 0.6152 -0.0330 0.0127 0.0252 HIPK1 TSS1500;TSS1500 chr1:114471965-114472899 N_Shore cg09379385 0.3461 -0.0348 0.0036 0.0184 HIST1H2AI TSS1500 chr6:27775329-27776258 N_Shore cg19514765 0.7371 -0.0382 0.0418 0.0313 HIST1H2BN TSS1500;1stExon;3'UTR chr6:27805843-27806853 N_Shore cg13836098 0.5285 -0.0688 0.0233 0.0164 HIST1H3E TSS200 chr6:26225386-26225790 N_Shore cg19268652 0.5806 -0.0465 0.0294 0.0327 HIVEP1 Body cg19170991 -0.4991 0.0459 0.0081 0.0024 HK1 Body;Body;Body;Body;Body cg26281025 -0.7192 0.0632 0.0006 0.0140 HK3 3'UTR chr5:176304965-176305166 S_Shelf cg12291348 0.2710 -0.0339 0.0194 0.0357 HLA-C Body chr6:31238852-31240120 Island cg22324029 -0.2990 0.0452 0.0438 0.0254 HLA-DMB Body cg01200893 0.5027 -0.0412 0.0473 0.0157 HLA-DOB TSS1500 cg08865625 0.5686 -0.0313 0.0126 0.0485 HLF Body chr17:53342198-53343061 S_Shelf cg13275679 -0.5248 0.0665 0.0018 0.0139 HN1 TSS1500;TSS1500;TSS1500 chr17:73149830-73150885 S_Shore cg11495399 -0.7779 0.0607 0.0038 0.0426 HNRNPUL2 TSS1500;TSS200 chr11:62493994-62495127 S_Shore cg09059988 1.3776 -0.0694 0.0002 0.0078 HORMAD1 1stExon;5'UTR cg11532431 0.8934 -0.0322 0.0050 0.0298 HOXA4 Body chr7:27169572-27170638 Island

cg26506288 0.3808 -0.0304 0.0430 0.0396 HOXB13 3'UTR chr17:46804203-46804415 N_Shore cg00893471 -0.2837 0.0537 0.0073 0.0228 HOXD3 5'UTR chr2:177029413-177029941 Island cg03095533 1.0349 -0.0391 0.0077 0.0352 HPN Body;Body chr19:35531780-35531991 S_Shelf cg10256662 0.4596 -0.0345 0.0495 0.0485 HPRT1 Body chrX:133594203-133594828 Island cg11220161 0.3686 -0.0624 0.0294 0.0356 HRK TSS1500 chr12:117318708-117319521 S_Shore cg20214871 -1.0077 0.1169 0.0369 0.0019 HRNBP3 TSS200 cg18575730 -0.3136 0.0308 0.0213 0.0443 HS6ST3 Body chr13:96742138-96744162 S_Shore cg01502872 -0.4490 0.0631 0.0051 0.0410 HSD17B8 Body chr6:33172289-33172823 S_Shore cg02025827 1.4232 -0.0791 0.0018 0.0022 HSD3B7 5'UTR;1stExon;1stExon;5'UTR;1stExon;5'UTR cg16587174 0.4757 -0.0706 0.0351 0.0146 HSPA1L Body chr6:31774475-31774862 S_Shelf cg03373442 0.7853 -0.0375 0.0112 0.0132 HSPH1 TSS1500 chr13:31735109-31736670 Island cg01306498 0.6431 -0.0419 0.0425 0.0243 HTATIP2 3'UTR;3'UTR;3'UTR;3'UTR chr11:20408755-20409781 N_Shelf cg24489774 -0.8414 0.0916 0.0027 0.0289 HTR2C 5'UTR;TSS1500 cg23332689 1.1902 -0.0679 0.0187 0.0306 IDUA Body;TSS1500;TSS1500;TSS1500 chr4:984926-985695 S_Shore cg18177731 0.3594 -0.0487 0.0037 0.0131 IFFO2 Body cg23893332 -0.2224 0.0380 0.0021 0.0208 IFI27 TSS1500;TSS1500 cg13304609 0.6908 -0.0938 0.0407 0.0243 IFI44L TSS1500 cg09757087 0.6852 -0.0852 0.0001 0.0061 IFT140 Body;Body chr16:1583809-1584641 S_Shore cg08125539 -0.6685 0.0725 0.0187 0.0193 IGF2BP1 Body;Body chr17:47072820-47076042 S_Shelf cg11135168 -0.5584 0.1000 0.0058 0.0285 IGFL2 TSS1500;TSS200 cg23066675 0.5600 -0.0386 0.0343 0.0052 IGSF11 Body;Body cg00386725 0.2811 -0.0371 0.0212 0.0223 IGSF21 Body cg18162528 0.6072 -0.0391 0.0105 0.0288 IGSF9B 1stExon;5'UTR chr11:133825337-133827457 Island cg19875535 0.7396 -0.0513 0.0403 0.0490 IK Body chr5:140026826-140027504 S_Shelf cg15488457 0.5116 -0.0324 0.0072 0.0453 IKZF2 3'UTR;3'UTR cg26279025 -0.8194 0.1140 0.0062 0.0293 IL11 TSS1500 chr19:55880577-55880922 S_Shore cg23969506 0.3693 -0.0375 0.0134 0.0464 IL17D Body cg16366604 0.5977 -0.0341 0.0340 0.0075 IL17RC Body;Body;Body chr3:9956822-9957664 S_Shelf cg18730511 -0.5023 0.0492 0.0063 0.0294 IL17REL 3'UTR chr22:50438257-50438776 N_Shelf cg09383860 -0.3416 0.0402 0.0361 0.0228 IL18BP TSS200;TSS1500;TSS200;TSS1500;TSS1500 cg19050351 -0.3570 0.0382 0.0178 0.0302 IL1F5 Body;Body cg14753070 0.4000 -0.0406 0.0383 0.0347 IL27RA 3'UTR cg27392904 -0.5589 0.0519 0.0162 0.0056 IL4I1 TSS1500;Body

cg24585690 0.6528 -0.0371 0.0082 0.0214 IL9 1stExon;5'UTR cg03147598 -0.3191 0.0401 0.0172 0.0290 IMP4 3'UTR chr2:131099469-131100863 S_Shelf cg14263426 0.9491 -0.0835 0.0151 0.0431 INCENP Body;Body cg05210373 -0.6802 0.0343 0.0175 0.0111 INF2 Body;Body cg17270821 0.7466 -0.0542 0.0068 0.0064 INPP5A Body chr10:134360859-134361084 S_Shore cg13001289 0.4079 -0.0426 0.0051 0.0391 INPP5K Body;Body;Body chr17:1419442-1420434 N_Shelf cg17100616 0.6937 -0.0423 0.0051 0.0347 INTS1 Body chr7:1523541-1523976 S_Shore cg22048132 1.3213 -0.0335 0.0366 0.0272 INTS2 1stExon;5'UTR;Body chr17:60004889-60005416 Island cg21796430 0.4619 -0.0382 0.0359 0.0237 INTS6 TSS1500;TSS1500;TSS1500 chr13:52025691-52027946 S_Shore cg18644782 -0.5612 0.0425 0.0075 0.0012 IQSEC1 Body cg09703963 -0.6497 0.0588 0.0009 0.0090 IRF7 TSS1500;TSS1500;3'UTR;TSS1500;3'UTR chr11:617226-617797 N_Shore cg08348990 0.3590 -0.0339 0.0269 0.0438 IRS2 Body cg16642791 0.4715 -0.0641 0.0345 0.0493 IRX5 Body chr16:54962422-54967805 Island cg20777315 -0.5974 0.0360 0.0033 0.0315 ISM1 Body chr20:13279711-13279947 Island cg05625471 0.6385 -0.0312 0.0062 0.0056 ITGAM Body;Body chr16:31342452-31343140 Island cg18566702 -0.2515 0.0337 0.0181 0.0084 ITGB4 Body;Body;Body chr17:73738579-73738810 N_Shore cg15521097 0.6718 -0.0520 0.0063 0.0055 ITIH5L 1stExon cg09453312 0.8154 -0.0644 0.0042 0.0465 ITK 1stExon cg14396306 -0.6813 0.0538 0.0023 0.0054 ITM2C Body;Body;Body cg02889647 0.6393 -0.0608 0.0274 0.0024 IVL TSS1500 cg04524668 1.1177 -0.0601 0.0029 0.0107 JAG2 Body;Body chr14:105615342-105615624 Island cg22231101 0.6066 -0.0791 0.0002 0.0062 JAKMIP1 Body cg10364109 0.5649 -0.0332 0.0214 0.0399 JAKMIP3 Body chr10:133937695-133938295 S_Shore cg07490283 0.4713 -0.0400 0.0381 0.0031 JDP2 3'UTR;3'UTR;3'UTR;3'UTR cg10959498 0.7975 -0.0425 0.0171 0.0491 JMJD1C Body;5'UTR cg02529544 1.0575 -0.0963 0.0136 0.0094 JPH3 Body cg08437802 -0.6004 0.0439 0.0141 0.0209 KANK2 Body;Body chr19:11303697-11304609 Island cg14792031 0.9609 -0.0565 0.0271 0.0337 KBTBD6 TSS1500 chr13:41706202-41707120 S_Shore cg04063166 -0.2580 0.0409 0.0001 0.0061 KCNA4 5'UTR chr11:30037672-30037944 N_Shelf cg13800769 -0.3705 0.0562 0.0154 0.0410 KCNA6 TSS1500 chr12:4918273-4919657 N_Shore cg02597153 1.0311 -0.0409 0.0079 0.0132 KCNC1 Body;Body chr11:17793276-17793959 Island cg16665234 0.7185 -0.0481 0.0349 0.0031 KCNC3 Body chr19:50826780-50827028 N_Shore cg02363526 1.0395 -0.1301 0.0292 0.0009 KCNH2 Body;Body chr7:150674737-150675026 N_Shore

cg20406482 0.2856 -0.0319 0.0180 0.0021 KCNH4 TSS1500 chr17:40332597-40333471 S_Shore cg19906454 -0.1919 0.0401 0.0293 0.0275 KCNJ4 5'UTR;TSS1500 cg12569736 -0.3417 0.0600 0.0170 0.0265 KCNK9 Body cg08252303 0.7136 -0.0634 0.0111 0.0088 KCNMA1 TSS1500;TSS1500;TSS1500;TSS1500 chr10:79396095-79398495 S_Shore cg21871203 0.4147 -0.0669 0.0082 0.0101 KCNMB3 Body;TSS200;TSS1500;Body;Body;Body cg27332243 2.5304 -0.0732 0.0018 0.0222 KCNN3 TSS200 cg06827779 0.6740 -0.0422 0.0118 0.0107 KCNQ1 Body;Body chr11:2603220-2603469 N_Shore cg26601317 0.2864 -0.0518 0.0251 0.0223 KCNQ1DN TSS1500 chr11:2890388-2891337 Island cg12627726 0.4473 -0.0338 0.0129 0.0205 KCNQ4 Body;Body cg13954127 0.6875 -0.0572 0.0249 0.0122 KCNT1 Body chr9:138678108-138678467 N_Shelf cg13454407 0.7307 -0.0307 0.0035 0.0274 KCNV1 TSS200 chr8:110986113-110986983 Island cg11069284 -0.8712 0.0332 0.0430 0.0153 KCTD14 Body cg04599840 0.5635 -0.0355 0.0273 0.0144 KDELR1 3'UTR cg06024930 0.3778 -0.0504 0.0066 0.0474 KDM2B Body;Body chr12:121890223-121890510 Island cg13357776 -0.6411 0.0380 0.0111 0.0063 KDM4B Body chr19:5110587-5110853 Island cg14437446 0.8121 -0.0511 0.0265 0.0340 KIAA0020 Body cg02025573 0.5963 -0.0331 0.0057 0.0051 KIAA0100 TSS1500 chr17:26971782-26972481 Island cg00780845 -0.7445 0.0534 0.0005 0.0186 KIAA1024 5'UTR chr15:79724099-79725643 Island cg12485744 0.6955 -0.0732 0.0120 0.0004 KIAA1026 Body;5'UTR;Body;Body cg00168417 -0.4000 0.0414 0.0399 0.0201 KIAA1210 TSS1500 chrX:118284519-118285065 S_Shore cg18699337 -0.5079 0.0959 0.0005 0.0064 KIAA1267 Body cg04892182 -1.2526 0.1273 0.0030 0.0164 KIAA1522 Body cg13929480 1.0919 -0.0357 0.0312 0.0319 KIAA1530 TSS1500 chr4:1340107-1341471 Island cg05179757 0.7748 -0.0442 0.0023 0.0024 KIAA1671 3'UTR cg20579564 0.5115 -0.0396 0.0197 0.0085 KIAA1688 Body chr8:145772645-145773966 N_Shore cg23181870 0.6649 -0.0374 0.0030 0.0370 KIAA1949 5'UTR;5'UTR;1stExon chr6:30654392-30654934 Island cg16333269 0.7989 -0.0397 0.0093 0.0006 KIDINS220 TSS1500 chr2:8977373-8977789 S_Shore cg22527425 0.8738 -0.0712 0.0489 0.0252 KIF17 TSS1500;TSS1500 chr1:21043832-21044771 Island cg17588812 0.8650 -0.0551 0.0013 0.0050 KIF1A Body cg07344172 1.0852 -0.0723 0.0146 0.0445 KIF21B Body cg23962342 -0.6613 0.0666 0.0104 0.0008 KIF26A Body chr14:104641258-104641762 Island cg14174928 0.6858 -0.0576 0.0030 0.0388 KIF26B Body cg27312338 0.3860 -0.0339 0.0100 0.0013 KIFC3 TSS1500;5'UTR;5'UTR chr16:57835955-57836989 N_Shelf

cg16837557 0.5448 -0.0521 0.0049 0.0463 KIRREL3 Body;Body cg16792560 1.2340 -0.0876 0.0446 0.0348 KLF13 Body chr15:31621655-31621893 S_Shelf cg14738273 0.5038 -0.0422 0.0063 0.0223 KLF15 5'UTR chr3:126074783-126076865 N_Shore cg00890649 0.5679 -0.1363 0.0205 0.0142 KLHDC3 Body chr6:42989178-42989510 N_Shore cg23556525 0.2615 -0.0318 0.0042 0.0244 KLHL15 5'UTR chrX:24042835-24044094 Island cg03043911 -0.3512 0.0326 0.0111 0.0139 KLHL4 TSS1500;TSS1500 cg11170179 0.7229 -0.0412 0.0001 0.0055 KLK10 5'UTR;5'UTR;5'UTR chr19:51522004-51522803 Island cg27361914 0.4855 -0.0535 0.0423 0.0185 KLK13 Body chr19:51568154-51568412 N_Shore cg13793157 -0.2970 0.0486 0.0026 0.0414 KLK4 TSS1500 chr19:51416002-51416249 N_Shore cg18330082 -0.1699 0.0331 0.0425 0.0212 KNDC1 Body chr10:134980302-134981059 S_Shelf cg08131100 -1.0953 0.0427 0.0092 0.0423 KRBA1 TSS1500 chr7:149410858-149412351 Island cg22506453 0.8791 -0.0562 0.0193 0.0260 KRT39 1stExon cg24461814 -0.1242 0.0314 0.0204 0.0035 KRT84 1stExon cg22443249 0.5954 -0.0374 0.0257 0.0312 KRTAP2-2 TSS1500 cg11043146 0.6911 -0.0368 0.0040 0.0427 KRTAP22-2 TSS1500;TSS1500 cg13506670 0.5406 -0.0493 0.0144 0.0326 KTN1 TSS1500;Body;TSS1500;TSS1500;TSS1500 chr14:56046634-56047986 N_Shore cg12039689 -0.4730 0.0717 0.0117 0.0059 L1CAM TSS1500;TSS1500;TSS1500 cg16773803 -0.3751 0.0359 0.0132 0.0220 L3MBTL 3'UTR;Body cg07532159 0.4335 -0.0313 0.0380 0.0177 LAMA2 Body;Body cg17409288 0.7520 -0.0354 0.0070 0.0370 LAP3 Body cg00574819 -0.6453 0.0609 0.0029 0.0268 LARP1B TSS1500;TSS1500;TSS1500 chr4:128981810-128983478 N_Shore cg08847335 -0.8127 0.0362 0.0034 0.0322 LARP4B Body cg16005883 1.0895 -0.0775 0.0124 0.0274 LARP7 5'UTR;TSS1500;5'UTR chr4:113558032-113558681 S_Shore cg16778811 -0.5341 0.0441 0.0353 0.0028 LASP1 Body chr17:37074860-37075097 N_Shelf cg14374861 0.7209 -0.0555 0.0068 0.0374 LBX1 Body;TSS1500 chr10:102984182-102990063 Island cg22044308 -0.6697 0.0455 0.0007 0.0110 LCE2D TSS1500 cg20239639 -0.4063 0.0473 0.0159 0.0097 LCK 5'UTR;TSS1500 chr1:32740710-32741544 N_Shore cg14633329 0.5261 -0.0456 0.0198 0.0426 LCN6 Body chr9:139640640-139640885 N_Shore cg26112909 -0.3682 0.0336 0.0288 0.0291 LDLRAD2 3'UTR;Body chr1:22149683-22149897 S_Shore cg26962002 0.7802 -0.0453 0.0037 0.0169 LENG8 Body chr19:54960191-54960948 S_Shelf cg24334632 -0.3732 0.0410 0.0084 0.0363 LEPREL1 5'UTR;Body cg11623476 -0.7671 0.0717 0.0158 0.0262 LFNG Body;Body;Body;Body chr7:2565872-2566114 Island cg18086521 0.8507 -0.0368 0.0192 0.0493 LGALS8 Body;Body;Body;Body chr1:236687071-236687608 S_Shelf

cg01460991 -0.2961 0.0557 0.0287 0.0173 LGI2 Body chr4:25032028-25032311 N_Shore cg10712554 -0.4927 0.0463 0.0096 0.0326 LGR6 Body;Body;Body cg15617023 -0.3855 0.0527 0.0282 0.0339 LHFP Body cg12894748 0.6204 -0.0365 0.0206 0.0305 LHFPL3 Body cg11189384 1.4263 -0.0785 0.0139 0.0230 LHX4 Body chr1:180198119-180204975 Island cg11842415 -0.4736 0.0365 0.0172 0.0464 LHX8 Body chr1:75600674-75601415 N_Shore cg17753347 -0.2722 0.0456 0.0012 0.0165 LHX9 Body chr1:197885060-197885389 N_Shore cg00727947 0.6370 -0.0461 0.0191 0.0099 LILRA5 TSS1500;TSS1500;TSS1500;TSS1500 cg19721087 0.3913 -0.0422 0.0118 0.0347 LIN28B TSS1500 chr6:105400877-105401149 S_Shelf cg22440951 -0.4436 0.0558 0.0042 0.0498 LIN9 3'UTR cg05212323 0.7476 -0.0384 0.0082 0.0295 LIPM 1stExon cg07143635 -0.4416 0.0393 0.0163 0.0472 LITAF TSS200;TSS1500;TSS1500;TSS1500 chr16:11680008-11681275 S_Shore cg13539171 -0.9459 0.0905 0.0405 0.0477 LLGL2 Body;Body chr17:73569163-73569410 Island cg16515546 -0.5403 0.0493 0.0447 0.0212 LMF1 TSS1500 chr16:1020219-1021303 S_Shore cg22017015 1.0319 -0.0541 0.0028 0.0244 LMNA Body;Body;Body cg05641348 0.4212 -0.0390 0.0320 0.0169 LMNB2 Body chr19:2455863-2457078 N_Shore cg13060233 0.6777 -0.0764 0.0361 0.0056 LMO7 5'UTR;Body cg13252613 0.6492 -0.0454 0.0035 0.0394 LOC100101121 TSS1500;TSS1500 chrY:9745559-9745993 S_Shore cg05979400 0.3212 -0.0304 0.0293 0.0305 LOC100128731 TSS1500 chr2:27294139-27294915 S_Shore cg03193299 0.3496 -0.0495 0.0003 0.0031 LOC100130872-SPON2Body;TSS1500;TSS1500 chr4:1164515-1166582 S_Shore cg24051554 0.3034 -0.0471 0.0391 0.0155 LOC100132111 Body;5'UTR chr1:151810460-151811684 Island cg22727572 1.0458 -0.0402 0.0168 0.0057 LOC100132215 Body;Body;Body;Body;Body chr2:63272127-63272409 Island cg12932211 0.5221 -0.0320 0.0079 0.0173 LOC100286948 TSS200;Body;Body cg09654116 0.5655 -0.0574 0.0435 0.0466 LOC154822 Body chr7:158816092-158816409 Island cg13505469 0.5982 -0.0375 0.0360 0.0311 LOC219347 TSS200;TSS200;Body;TSS200;TSS200;TSS200 chr10:81838359-81839078 Island cg20738500 0.5530 -0.0377 0.0261 0.0017 LOC254559 TSS200 chr15:89920793-89922768 Island cg15808604 -0.5956 0.0704 0.0388 0.0408 LOC283731 Body chr15:74419870-74423044 N_Shore cg08767637 -0.3131 0.0410 0.0015 0.0227 LOC283867 Body cg22488719 0.4674 -0.0579 0.0241 0.0359 LOC285205 TSS1500 cg22620414 0.3511 -0.0501 0.0030 0.0381 LOC285370 TSS1500 cg12467226 -0.2467 0.0351 0.0343 0.0387 LOC285375 Body chr3:13696627-13697127 N_Shelf cg17774418 0.8446 -0.0483 0.0122 0.0320 LOC285780 Body;Body

cg02945359 0.7590 -0.0447 0.0035 0.0337 LOC285830 Body;Body;Body chr6:29691106-29692093 S_Shelf cg26723524 -0.7692 0.0703 0.0173 0.0494 LOC349114 Body chr7:39772839-39773252 S_Shelf cg21735115 0.7674 -0.0333 0.0309 0.0101 LOC374443 TSS1500 chr12:9800543-9800852 N_Shore cg26363555 -0.2130 0.0307 0.0260 0.0470 LOC399959 Body cg22732432 1.1214 -0.0589 0.0150 0.0410 LOC400027 TSS200 chr12:46120726-46124104 Island cg24147392 0.5491 -0.0447 0.0260 0.0315 LOC440461 Body chr17:66192363-66195873 Island cg25318278 -0.2100 0.0405 0.0464 0.0116 LOC441601 TSS200 chr11:50257255-50257772 S_Shore cg20788133 -0.8744 0.0770 0.0138 0.0444 LOC643837 Body chr1:762416-763445 S_Shore cg20550513 0.8165 -0.0587 0.0096 0.0200 LOC651250 Body chr17:66097528-66098631 S_Shore cg24809698 -0.5575 0.0363 0.0022 0.0105 LOC731789 TSS200 cg25340786 0.6883 -0.0525 0.0149 0.0282 LOC93432 TSS1500 cg08017756 -0.5794 0.0567 0.0318 0.0396 LONRF2 TSS200 chr2:100937779-100939059 S_Shore cg19282019 0.7737 -0.0492 0.0031 0.0068 LOXHD1 TSS1500;Body chr18:44140362-44140575 N_Shore cg08864083 -0.5207 0.0318 0.0054 0.0306 LOXL2 Body cg15989091 0.1698 -0.0332 0.0425 0.0091 LOXL3 5'UTR chr2:74781494-74782685 N_Shore cg16533510 0.8302 -0.0370 0.0186 0.0328 LPCAT1 Body cg25977938 0.5554 -0.0565 0.0456 0.0028 LPPR5 Body;Body cg16385330 0.8703 -0.1078 0.0462 0.0131 LRBA Body;1stExon;5'UTR chr4:151504011-151505085 N_Shore cg11885324 0.4519 -0.0568 0.0053 0.0181 LRIT1 Body chr10:85997109-85997427 N_Shelf cg27352715 -0.5681 0.0727 0.0100 0.0378 LRIT2 1stExon cg22799110 -0.4536 0.0360 0.0006 0.0117 LRP5 Body chr11:68181086-68181289 Island cg26191586 -0.4680 0.0519 0.0045 0.0111 LRP8 TSS1500;TSS1500;TSS1500;TSS1500 chr1:53791687-53793496 S_Shore cg26263234 -0.3289 0.0532 0.0346 0.0163 LRRC3B 5'UTR chr3:26665950-26666164 Island cg13933859 0.8801 -0.0959 0.0308 0.0282 LRRK1 Body chr15:101513245-101514323 N_Shore cg14139935 -0.7249 0.0454 0.0065 0.0384 LRSAM1 Body;Body;Body cg24552015 0.6540 -0.0654 0.0155 0.0377 LSP1 5'UTR;TSS200;TSS200;Body chr11:1892037-1892556 Island Body;TSS1500;TSS1500;5'UTR;TSS1500;5'UT cg09761080 -0.2215 0.0353 0.0041 0.0129 LST1 R;Body;5'UTR;1stExon cg09274091 0.9475 -0.1135 0.0003 0.0109 LTB4R 5'UTR;TSS1500;TSS1500 chr14:24779874-24780932 S_Shore cg21301224 0.4301 -0.0317 0.0161 0.0016 LYN 5'UTR;5'UTR cg26370158 -0.7667 0.0459 0.0330 0.0431 LYST Body cg19499884 0.9702 -0.1355 0.0064 0.0093 LZTS2 5'UTR chr10:102756834-102759798 S_Shore cg03840849 0.4375 -0.0451 0.0178 0.0358 MACC1 TSS1500

cg18546384 -0.6888 0.0423 0.0031 0.0002 MAD1L1 Body;Body;Body cg17879352 -0.3809 0.0464 0.0241 0.0022 MAEA Body;Body chr4:1320098-1320301 N_Shore cg05573182 1.0908 -0.0501 0.0165 0.0136 MAFB TSS1500 chr20:39316550-39319987 Island cg00117663 0.6249 -0.0377 0.0251 0.0498 MAGEB16 TSS200 cg22072691 0.4180 -0.0438 0.0008 0.0098 MAGED2 Body;TSS1500;Body;Body cg20311601 0.9107 -0.0533 0.0376 0.0057 MAGI2 Body cg04831694 -0.5437 0.0558 0.0125 0.0500 MAK TSS1500 cg03129884 0.9758 -0.0719 0.0092 0.0435 MAL Body;Body;Body;Body chr2:95690857-95692431 S_Shore cg23566411 0.9282 -0.0681 0.0354 0.0026 MALAT1 TSS1500 chr11:65264957-65265398 N_Shore cg21396956 0.8963 -0.0647 0.0153 0.0039 MALT1 Body;Body chr18:56338211-56339277 S_Shore cg03371275 0.7809 -0.0527 0.0239 0.0139 MAML2 Body cg07533819 0.3756 -0.0501 0.0190 0.0404 MAP1B Body chr5:71402877-71404868 S_Shelf cg03391426 0.9810 -0.0459 0.0176 0.0202 MAP7D1 3'UTR chr1:36641756-36642461 S_Shelf cg05181212 0.1819 -0.0410 0.0426 0.0383 MAPK10 5'UTR;5'UTR;5'UTR cg09080909 0.6410 -0.0465 0.0027 0.0008 MAPK8IP3 Body;Body chr16:1796810-1797229 Island cg13188869 0.7479 -0.0366 0.0201 0.0361 MAPKAPK3 TSS1500 chr3:50654276-50655120 Island cg15221532 1.0791 -0.0642 0.0006 0.0099 MARCH10 Body;Body cg04348222 0.1733 -0.0307 0.0271 0.0203 MARCKSL1 TSS1500 chr1:32800859-32802229 S_Shore cg18823904 0.7512 -0.0373 0.0022 0.0071 MARK3 Body;Body;Body;Body;Body cg05817232 1.3047 -0.1477 0.0026 0.0123 MARK4 Body chr19:45754630-45755261 Island cg06340704 0.4422 -0.0386 0.0088 0.0328 MBNL2 5'UTR;5'UTR cg00706570 0.4471 -0.0433 0.0041 0.0020 MBP 3'UTR;3'UTR;3'UTR;3'UTR;3'UTR chr18:74691262-74691466 S_Shore cg19028462 0.7035 -0.0982 0.0028 0.0084 MCF2L Body;Body chr13:113677627-113677836 Island cg13227206 0.5773 -0.0301 0.0183 0.0156 MCOLN2 Body cg15129679 0.4383 -0.0368 0.0111 0.0065 MCOLN3 5'UTR chr1:85513509-85514555 N_Shore cg26193015 0.3477 -0.0359 0.0119 0.0452 MDC1 5'UTR chr6:30684836-30685503 N_Shore cg11605108 -0.4745 0.0375 0.0084 0.0451 MED24 Body;Body chr17:38210767-38210975 N_Shelf cg01034631 -0.3711 0.0435 0.0284 0.0154 MEG8 TSS200 cg25221496 0.4324 -0.0349 0.0075 0.0238 MEIS2 Body;Body;Body;Body;Body;Body;Body chr15:37387386-37387614 N_Shore cg14431547 0.5558 -0.0628 0.0089 0.0477 MELK TSS1500 chr9:36572703-36573073 N_Shore cg07651189 -0.3470 0.0647 0.0488 0.0217 MEPE TSS1500 cg26651775 -0.4451 0.0500 0.0161 0.0450 METRN TSS1500 chr16:764748-765994 N_Shore cg02633149 0.4998 -0.0552 0.0024 0.0349 METRNL Body chr17:81042626-81043244 Island

cg06544937 -1.1465 0.0441 0.0284 0.0147 METT5D1 5'UTR;TSS1500;5'UTR chr11:28131863-28132221 N_Shore cg09418267 0.4474 -0.0389 0.0057 0.0059 MEX3D 3'UTR chr19:1555010-1555213 Island cg10201923 0.5975 -0.0358 0.0325 0.0322 MFAP2 TSS1500;TSS1500;TSS1500;TSS1500 chr1:17306551-17307363 S_Shore cg26894288 0.5434 -0.0549 0.0021 0.0007 MFGE8 Body;Body cg04442042 -0.3547 0.0688 0.0056 0.0305 MFHAS1 Body cg01869896 -0.2890 0.0434 0.0013 0.0041 MFSD2A TSS1500;TSS1500 chr1:40420487-40421366 N_Shore cg04186606 -0.5758 0.0439 0.0284 0.0344 MFSD7 Body chr4:681313-681514 N_Shore cg21160192 -0.8499 0.0308 0.0118 0.0008 MGAT1 5'UTR;5'UTR;5'UTR;5'UTR;5'UTR chr5:180229375-180230147 Island cg09736950 -1.0030 0.0540 0.0028 0.0332 MGC15885 TSS1500;TSS1500 cg02803836 0.6402 -0.0380 0.0229 0.0129 MGMT Body cg26700932 0.7575 -0.0598 0.0013 0.0085 MGRN1 Body;Body;Body;Body chr16:4702628-4702851 S_Shore cg00874480 0.4062 -0.0501 0.0260 0.0395 MGST1 Body;Body;Body;Body cg05642789 0.8640 -0.0547 0.0001 0.0039 MIB2 Body;Body;Body;Body;Body;Body chr1:1564421-1570006 Island cg23381224 -1.1464 0.1213 0.0051 0.0083 MINPP1 Body cg20788415 0.4930 -0.0406 0.0374 0.0307 MIR106A TSS1500 chrX:133305678-133306936 Island cg11201447 -0.9115 0.0805 0.0004 0.0084 MIR1204 TSS200;Body chr8:128806081-128806899 S_Shore cg11175091 -0.5730 0.0634 0.0378 0.0026 MIR1243 TSS1500;Body;Body;Body cg03307581 -0.2346 0.0372 0.0429 0.0313 MIR1289-2 TSS1500;Body cg14892570 0.4645 -0.0390 0.0235 0.0024 MIR1470 TSS1500;5'UTR cg07513814 -0.2202 0.0386 0.0367 0.0218 MIR1471 TSS1500 cg09732987 0.7026 -0.0376 0.0002 0.0095 MIR17HG TSS1500;TSS1500 chr13:91999541-92001441 Island cg25511278 0.9437 -0.1597 0.0428 0.0261 MIR219-1 TSS1500;Body chr6:33175561-33176387 N_Shore cg19321304 -0.5362 0.0419 0.0260 0.0364 MIR320B1 TSS1500 chr1:117209824-117210621 S_Shelf cg11721554 -0.4852 0.0435 0.0213 0.0049 MIR377 TSS1500 chr14:101531643-101532384 N_Shelf cg25047306 0.5404 -0.0421 0.0257 0.0426 MIR384 TSS1500 cg20704442 -0.2718 0.0391 0.0012 0.0015 MIR548F5 Body;Body chr13:36052553-36053119 Island cg16796899 0.6378 -0.0397 0.0318 0.0315 MIR656 Body chr14:101531643-101532384 S_Shore cg14189049 0.7400 -0.0936 0.0084 0.0407 MIR9-3 TSS1500 chr15:89910521-89912177 N_Shore cg06070625 -0.3431 0.0356 0.0019 0.0039 MITF Body;TSS200 cg16208863 0.3879 -0.0339 0.0321 0.0161 MLLT1 Body chr19:6230103-6230306 Island cg18264687 0.9003 -0.0487 0.0031 0.0175 MLLT3 5'UTR;1stExon chr9:20620728-20621862 S_Shore cg26255831 0.7318 -0.0543 0.0003 0.0119 MMP14 Body chr14:23305893-23307013 S_Shelf cg25400200 -0.4871 0.0527 0.0025 0.0106 MMP21 Body chr10:127462230-127462987 N_Shore

cg08747557 0.7280 -0.0678 0.0034 0.0016 MMP8 3'UTR cg10841673 0.6148 -0.0389 0.0461 0.0425 MOCS3 TSS200;TSS1500 chr20:49574816-49576287 Island 3'UTR;Body;3'UTR;Body;Body;Body;Body;B cg02475474 -0.2854 0.0553 0.0241 0.0252 MOG ody;Body;Body;Body cg05798059 -0.1751 0.0329 0.0216 0.0460 MPPED2 Body;Body cg26771557 0.3240 -0.0303 0.0152 0.0230 MPRIP Body;Body cg11802469 0.9625 -0.0858 0.0368 0.0479 MRAP2 TSS1500 chr6:84743357-84743948 N_Shore cg25807487 -0.5185 0.0847 0.0206 0.0079 MRGPRF TSS1500;TSS1500 chr11:68778569-68778851 S_Shelf cg23310975 0.7056 -0.0487 0.0301 0.0342 MRPL13 Body chr8:121457353-121457657 N_Shelf cg14795268 -0.6752 0.0305 0.0190 0.0159 MRPL20 Body chr1:1342004-1342952 N_Shore cg14836313 0.6788 -0.0744 0.0477 0.0464 MRPL23 Body chr11:1977523-1977765 N_Shore cg11469325 0.7135 -0.0306 0.0358 0.0360 MRPS16 1stExon;5'UTR chr10:75012126-75012531 Island cg17630127 0.7141 -0.0530 0.0101 0.0153 MS4A5 TSS1500 cg24393665 0.9856 -0.0875 0.0388 0.0418 MSL3 5'UTR;Body;Body;Body chrX:11775784-11776936 S_Shelf cg17440757 0.3897 -0.0507 0.0222 0.0329 MSMB Body;Body chr10:51565071-51565648 N_Shelf cg07355157 0.2772 -0.0387 0.0367 0.0170 MSRB2 Body chr10:23384533-23385078 S_Shore cg05958050 -0.6115 0.0684 0.0202 0.0282 MT1G TSS1500;TSS1500 chr16:56703387-56703648 Island cg26117622 0.7933 -0.0350 0.0163 0.0470 MTERFD2 TSS1500;TSS1500;TSS1500;TSS1500 chr2:242041543-242042026 S_Shore cg13470367 -0.4186 0.0414 0.0082 0.0343 MTF1 TSS1500 chr1:38325150-38325999 S_Shore cg15241130 -0.6495 0.0895 0.0077 0.0388 MTHFD1L Body cg00414384 0.7949 -0.0398 0.0304 0.0210 MTL5 Body;Body chr11:68517667-68518179 Island cg13630878 -0.3169 0.0484 0.0097 0.0338 MTMR15 Body cg26046924 -0.5217 0.0485 0.0423 0.0358 MTMR8 TSS1500 chrX:63614957-63615423 S_Shore cg19977866 0.5425 -0.0401 0.0269 0.0329 MTNR1B Body chr11:92702789-92703434 S_Shore cg13906098 -0.5908 0.0486 0.0149 0.0135 MUC17 TSS200 cg13957457 1.2184 -0.0913 0.0362 0.0232 MUC2 Body chr11:1107802-1108041 N_Shelf cg07974485 -0.2510 0.0370 0.0042 0.0239 MUC6 Body chr11:1024003-1024492 S_Shore cg23674169 0.5279 -0.0881 0.0189 0.0198 MUM1 TSS200;5'UTR chr19:1354420-1355350 S_Shore cg11414742 0.3812 -0.0575 0.0319 0.0372 MXRA8 3'UTR chr1:1289707-1291126 N_Shore cg15769920 -0.3953 0.0304 0.0029 0.0140 MYL6B TSS1500 chr12:56546192-56546411 N_Shore cg20142309 -0.3993 0.0564 0.0468 0.0310 MYO18A TSS1500;TSS1500 chr17:27506889-27507607 S_Shore cg07332330 -1.2534 0.0533 0.0391 0.0125 MYO1C 5'UTR;Body;TSS1500 chr17:1388686-1389730 Island cg22798362 0.7363 -0.0317 0.0011 0.0041 MYO1D Body chr17:30845903-30846702 S_Shelf

cg08891123 -0.7986 0.0437 0.0229 0.0118 MYO1E Body cg21188037 0.5841 -0.0449 0.0125 0.0456 MYO1G 5'UTR;1stExon cg24961970 0.5230 -0.0327 0.0396 0.0285 MYO1H 3'UTR cg06363798 -0.6240 0.0623 0.0143 0.0277 MYOC 3'UTR cg05486872 -0.4169 0.0528 0.0042 0.0251 MYOM1 3'UTR;3'UTR chr18:3067297-3067533 N_Shore cg00480231 0.1920 -0.0366 0.0311 0.0383 MYT1L 5'UTR chr2:2193510-2193716 S_Shelf cg18120808 -0.4560 0.0565 0.0143 0.0134 NAF1 TSS1500;TSS1500 chr4:164087461-164088146 S_Shore cg24080291 0.6042 -0.0417 0.0177 0.0492 NARS2 Body;Body chr11:78285405-78285995 N_Shelf cg00910355 -0.4323 0.0437 0.0287 0.0160 NAT15 5'UTR chr16:3507545-3508606 N_Shelf cg13372293 0.5850 -0.0463 0.0171 0.0370 NBEAL1 TSS1500 chr2:203879249-203879891 N_Shore cg06614336 -0.7601 0.0614 0.0200 0.0469 NCAPG2 Body cg20502854 -0.2583 0.0342 0.0195 0.0424 NCKAP5 Body;Body cg12052114 0.5764 -0.0517 0.0406 0.0158 NCL Body;TSS1500;TSS200 cg02492405 -0.7432 0.0423 0.0012 0.0071 NCOA2 5'UTR cg25763426 0.6457 -0.0364 0.0344 0.0232 NCOR2 Body;Body chr12:124901064-124901441 S_Shelf cg05138681 -0.2788 0.0499 0.0019 0.0094 NCRNA00092 Body chr9:98783216-98784364 N_Shore cg00995670 0.7097 -0.0493 0.0170 0.0361 NCRNA00171 Body cg18103043 0.7012 -0.0731 0.0083 0.0287 NCRNA00176 TSS1500;TSS1500 chr20:62660961-62661352 S_Shelf cg11267496 0.3256 -0.0341 0.0285 0.0048 NDP TSS200 cg07062933 0.4897 -0.0329 0.0029 0.0216 NDRG1 TSS1500;TSS1500 chr8:134308328-134310145 Island cg25733559 0.6665 -0.0570 0.0031 0.0202 NDUFA12 TSS1500 chr12:95397382-95397611 S_Shore cg14755054 0.8205 -0.0683 0.0458 0.0351 NDUFB3 5'UTR chr2:201936024-201936376 S_Shelf cg19038228 1.3171 -0.0629 0.0042 0.0496 NDUFV1 TSS1500;TSS1500 chr11:67374150-67374726 N_Shore cg08762432 0.3177 -0.0450 0.0192 0.0450 NEBL Body cg14263969 0.5743 -0.0353 0.0027 0.0175 NECAB3 Body;Body;TSS200 chr20:32251123-32251832 N_Shore cg10433327 -0.3462 0.0339 0.0142 0.0052 NEDD4 TSS200;Body 5'UTR;Body;5'UTR;5'UTR;5'UTR;Body;Body; cg17017564 0.5731 -0.0346 0.0209 0.0166 NEDD4L Body;5'UTR chr18:55922987-55924068 N_Shelf cg20256245 0.7482 -0.0577 0.0048 0.0450 NEFH Body chr22:29875919-29877242 S_Shore cg13387869 0.6019 -0.0489 0.0111 0.0222 NEFM 3'UTR;3'UTR chr8:24770908-24772547 S_Shelf cg03387238 -0.4326 0.0304 0.0210 0.0271 NEIL1 Body;TSS1500 chr15:75648404-75648709 N_Shore cg17742559 -0.3411 0.0300 0.0035 0.0350 NEK8 Body chr17:27070538-27071570 N_Shelf cg27258696 0.7094 -0.0643 0.0479 0.0062 NELL1 Body;Body

cg05767035 0.5875 -0.0404 0.0464 0.0252 NELL2 Body;Body;Body;Body;Body cg12598025 0.5622 -0.0431 0.0086 0.0273 NEURL1B Body cg25567448 0.2530 -0.0475 0.0326 0.0377 NEURL3 TSS1500 chr2:97173851-97174485 S_Shore cg21850879 0.7656 -0.0431 0.0221 0.0215 NF1 Body;3'UTR;Body cg17449235 0.6240 -0.0622 0.0333 0.0439 NFASC Body;Body;Body;Body cg23240477 0.6592 -0.0363 0.0226 0.0352 NFATC1 Body;Body;Body;Body chr18:77230597-77230803 N_Shore cg13118545 0.2917 -0.0311 0.0284 0.0480 NFE2L3 TSS1500 chr7:26191794-26192757 N_Shore cg08037935 0.8504 -0.0353 0.0061 0.0275 NFIA Body;TSS1500;TSS1500;TSS200 chr1:61548753-61549564 N_Shore cg14543226 -0.4402 0.0333 0.0181 0.0132 NFIC Body;Body chr19:3387963-3388203 N_Shelf cg14290576 0.1804 -0.0346 0.0118 0.0465 NFIL3 5'UTR chr9:94183407-94183994 N_Shore cg05503349 0.7368 -0.0304 0.0262 0.0187 NFYB 5'UTR chr12:104531174-104532539 Island cg22819824 -0.6860 0.0575 0.0231 0.0106 NHLRC2 Body chr10:115614373-115615056 S_Shelf cg06297391 -0.7445 0.0528 0.0410 0.0176 NHLRC4 TSS1500 chr16:614792-615095 S_Shore cg18765906 0.3699 -0.0449 0.0272 0.0489 NID1 Body cg17868994 0.7833 -0.0344 0.0010 0.0055 NIPSNAP3B TSS200 chr9:107526172-107526779 Island cg07015221 -0.7135 0.0476 0.0050 0.0018 NKD2 Body chr5:1037964-1038426 N_Shelf cg05939513 -0.4926 0.0333 0.0075 0.0159 NLGN4Y Body;Body;Body chrY:16941822-16942188 S_Shore cg23093333 -0.7960 0.0562 0.0179 0.0079 NLK Body cg23985930 0.6155 -0.0567 0.0054 0.0143 NLRP5 TSS1500 cg15343797 -0.6045 0.0426 0.0025 0.0029 NLRX1 3'UTR;TSS1500;Body;TSS1500 cg05546038 0.5921 -0.0539 0.0140 0.0251 NOL3 TSS1500 chr16:67208067-67208678 N_Shore cg14120703 0.5356 -0.0335 0.0435 0.0306 NOTCH1 Body chr9:139417115-139417518 N_Shore cg19157199 0.7001 -0.0548 0.0354 0.0184 NOX3 TSS1500 cg10224655 0.7759 -0.0952 0.0128 0.0003 NPHP4 TSS1500 chr1:6051595-6052955 S_Shore cg20557999 0.4426 -0.0489 0.0024 0.0199 NPTX1 3'UTR chr17:78442568-78442849 Island cg08415785 0.5002 -0.0885 0.0265 0.0072 NR0B1 TSS1500 chrX:30326439-30327668 S_Shore cg08098450 -1.0093 0.0640 0.0374 0.0181 NR1H4 Body

1stExon;1stExon;1stExon;5'UTR;1stExon;1st Exon;5'UTR;5'UTR;5'UTR;5'UTR;1stExon;1st Exon;5'UTR;1stExon;5'UTR;5'UTR;5'UTR;5'U TR;5'UTR;1stExon;1stExon;1stExon;5'UTR;1s tExon;5'UTR;5'UTR;1stExon;1stExon;5'UTR; cg25214346 -0.1400 0.0348 0.0066 0.0491 NR1I3 1stExon

cg23676151 -0.5874 0.0685 0.0483 0.0320 NR2E1 Body chr6:108491033-108491410 Island cg26446929 1.7072 -0.1377 0.0102 0.0491 NR4A1 5'UTR;5'UTR chr12:52444553-52445421 S_Shore Body;Body;Body;Body;Body;Body;Body;Bod cg17661135 0.5485 -0.0588 0.0144 0.0316 NRG1 y;Body;Body;Body;Body cg10307632 -0.9432 0.0521 0.0152 0.0371 NRP2 Body;Body;Body;Body;Body cg07256668 0.5841 -0.0376 0.0014 0.0255 NRXN2 Body;Body;Body chr11:64397644-64398016 S_Shore cg21265548 1.4496 -0.2486 0.0010 0.0207 NSDHL 5'UTR;5'UTR;TSS1500 chrX:151999149-151999751 S_Shore cg02917210 0.6859 -0.0415 0.0255 0.0306 NSMCE2 TSS1500;5'UTR chr8:126103760-126104122 N_Shore cg23369601 0.6064 -0.0494 0.0067 0.0075 NSUN2 Body chr5:6632740-6634162 N_Shore cg04493247 0.6450 -0.0496 0.0126 0.0315 NSUN5 Body;Body;Body;Body chr7:72717665-72717985 S_Shore cg01377911 0.4345 -0.0506 0.0137 0.0489 NTF4 TSS1500 cg03393889 -0.2642 0.0316 0.0011 0.0228 NTHL1 Body chr16:2097465-2098365 N_Shelf cg23493497 0.4723 -0.0505 0.0065 0.0247 NTM Body;Body;Body;Body cg24346905 -0.7060 0.0446 0.0309 0.0486 NTNG1 Body;Body;Body chr1:108023232-108023442 Island cg04131010 -0.7310 0.0446 0.0215 0.0450 NUDT1 Body;Body;Body;Body;Body;Body;Body cg27042667 0.5878 -0.0321 0.0044 0.0127 NUF2 Body;Body chr1:163291479-163292021 S_Shelf cg22311942 1.1109 -0.0613 0.0227 0.0161 NUP85 TSS1500 chr17:73201326-73202122 Island cg12740087 -0.5770 0.0491 0.0190 0.0020 NVL Body;Body;TSS1500 cg05575733 -0.6984 0.0490 0.0262 0.0333 NXN Body chr17:708319-708598 Island cg01933308 0.6008 -0.0442 0.0300 0.0005 NXPH1 Body chr7:8483132-8483711 Island cg08881871 -0.2188 0.0500 0.0481 0.0309 OBSCN Body;Body chr1:228503556-228504762 Island cg03261633 0.4990 -0.0370 0.0276 0.0144 OBSL1 Body chr2:220428115-220428342 Island cg15843691 0.4752 -0.0342 0.0144 0.0496 OCA2 Body chr15:28015346-28015795 N_Shore cg24379599 0.6984 -0.0565 0.0030 0.0177 OCLM TSS1500;Body;Body;Body;Body cg17818912 -0.3250 0.0447 0.0433 0.0401 OCLN TSS1500 chr5:68788151-68789823 N_Shore cg03791434 0.7373 -0.0413 0.0222 0.0431 OCRL Body;Body chrX:128674133-128674727 S_Shelf cg06589421 -0.5182 0.0570 0.0310 0.0486 ODZ3 3'UTR chr4:183720658-183721739 S_Shore cg27153782 0.6327 -0.0787 0.0477 0.0259 OLAH 5'UTR;5'UTR cg00014194 0.3521 -0.0551 0.0038 0.0367 OLFM1 Body;Body chr9:137978821-137980254 N_Shore cg00488788 -1.1223 0.0891 0.0292 0.0223 ONECUT1 Body chr15:53076187-53077926 Island cg12591625 -0.2896 0.0407 0.0222 0.0003 OPCML Body chr11:133230884-133231645 S_Shore cg03309898 0.3359 -0.0381 0.0111 0.0470 OPLAH Body chr8:145114550-145115828 Island cg17786206 -0.3698 0.0518 0.0076 0.0216 OPRD1 Body chr1:29138501-29139348 S_Shelf

cg01004457 -0.9095 0.0557 0.0479 0.0270 OR10H3 TSS1500 cg02650767 -0.2716 0.0479 0.0041 0.0029 OR2B11 1stExon chr1:247614695-247614944 S_Shore cg16274221 -0.6128 0.0729 0.0363 0.0346 OR2T1 TSS1500 cg19519899 0.8416 -0.0562 0.0394 0.0083 OR2T33 TSS200 cg20615517 0.4649 -0.0319 0.0195 0.0060 OR3A4 Body cg20084079 0.5097 -0.0618 0.0019 0.0267 OR4A15 1stExon cg25747935 0.4834 -0.0449 0.0419 0.0349 OR51A2 TSS1500 cg26148471 0.5644 -0.0312 0.0069 0.0181 OR5AS1 TSS1500 cg09831620 0.7345 -0.0419 0.0090 0.0400 OR5H2 1stExon cg05369553 0.7428 -0.0473 0.0334 0.0390 OR6K3 TSS1500 cg14514991 0.3953 -0.0601 0.0105 0.0169 OR6N1 TSS1500 cg08460629 0.4566 -0.0337 0.0286 0.0028 OR7E156P Body cg00320138 0.8098 -0.0437 0.0323 0.0031 OR8D1 TSS1500 cg07598370 0.7292 -0.0464 0.0080 0.0297 OR8U8 Body;1stExon cg21253590 0.5981 -0.0872 0.0106 0.0014 ORAI2 TSS1500;TSS1500 chr7:102073605-102074334 N_Shore cg03242344 0.5098 -0.0316 0.0040 0.0346 ORAOV1 Body chr11:69489754-69490329 N_Shore cg03174521 0.5270 -0.0457 0.0061 0.0305 OSBPL5 5'UTR;5'UTR;5'UTR chr11:3181574-3182120 N_Shelf cg17451879 0.9468 -0.1028 0.0314 0.0128 OSBPL9 3'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR;3'UTR cg20707692 -0.3478 0.0367 0.0299 0.0129 OSR1 5'UTR chr2:19555789-19558403 N_Shore cg09222115 0.5110 -0.0540 0.0119 0.0374 OTOS 5'UTR chr2:241075403-241075916 S_Shelf cg21933175 0.4216 -0.0423 0.0048 0.0116 OTX1 TSS1500 chr2:63274475-63279430 Island cg15607672 -0.5035 0.0591 0.0066 0.0088 OTX2 TSS200 chr14:57278068-57278287 N_Shore cg04731988 -0.4344 0.0421 0.0040 0.0487 OXT TSS1500 chr20:3052097-3053103 N_Shore cg22373508 -0.2004 0.0459 0.0380 0.0468 P2RX2 Body;Body;Body;Body;Body;Body chr12:133194868-133195544 S_Shore cg16955074 0.7648 -0.0427 0.0106 0.0174 P2RX4 3'UTR cg15867829 -0.3181 0.0444 0.0134 0.0236 PABPC4L 3'UTR cg18853010 0.8466 -0.0329 0.0039 0.0293 PACS2 Body;Body chr14:105836031-105836386 Island cg06059147 -0.4224 0.0423 0.0031 0.0144 PADI1 Body cg15149491 -0.6859 0.0477 0.0470 0.0036 PAK4 Body;Body;Body;Body;Body chr19:39663600-39663815 N_Shore cg17914107 0.6510 -0.0574 0.0333 0.0033 PALLD Body;Body cg21885107 0.2657 -0.0384 0.0034 0.0100 PAPLN Body chr14:73712288-73712911 Island cg22805909 0.8671 -0.0536 0.0047 0.0463 PAPOLA TSS1500 chr14:96968154-96969371 N_Shore cg09461005 0.4712 -0.0310 0.0420 0.0337 PARD3 Body

cg03124214 0.5448 -0.0895 0.0019 0.0034 PARN Body;Body cg22989843 0.7041 -0.0907 0.0255 0.0071 PAX3 Body;Body;Body;Body;Body;Body chr2:223155726-223156154 N_Shore cg16113298 0.9365 -0.0516 0.0484 0.0433 PAX6 5'UTR;1stExon;5'UTR;5'UTR chr11:31831620-31839038 Island cg19073171 -0.4782 0.0549 0.0316 0.0244 PAXIP1 Body;TSS1500 chr7:154794017-154795750 N_Shore cg14031054 0.4472 -0.0479 0.0026 0.0034 PBX1 Body cg09001226 0.5187 -0.0369 0.0323 0.0464 PBX2 Body cg26005973 -0.2034 0.0324 0.0431 0.0499 PCBD1 3'UTR cg12162886 0.3680 -0.0446 0.0022 0.0217 PCBP3 Body;Body chr21:47318509-47318900 Island cg09150559 0.5551 -0.0375 0.0031 0.0062 PCDHB10 TSS1500 chr5:140573423-140574316 N_Shore cg19967668 -0.6361 0.0606 0.0143 0.0312 PCDHB17 Body chr5:140536896-140537766 N_Shore cg23918315 0.4558 -0.0493 0.0262 0.0405 PCDHB3 TSS1500 chr5:140481546-140482460 N_Shelf

Body;Body;Body;Body;Body;Body;Body;Bod y;Body;Body;Body;Body;Body;Body;Body;B cg05197036 0.6521 -0.0409 0.0422 0.0228 PCDHGA4 ody;Body;Body;Body;Body chr5:140821228-140821688 S_Shelf cg15843217 -0.3814 0.0578 0.0378 0.0122 PCGF3 TSS1500 chr4:699541-699951 N_Shore cg14382564 0.5585 -0.0489 0.0189 0.0421 PCLO Body;Body cg06008158 1.1363 -0.0451 0.0110 0.0042 PCM1 5'UTR chr8:17780032-17781272 S_Shore cg09563451 -0.8047 0.0708 0.0031 0.0293 PCNA 5'UTR chr20:5107202-5108086 N_Shelf Body;Body;Body;Body;Body;Body;Body;Bod cg24494009 -0.4611 0.0398 0.0366 0.0027 PCSK6 y cg20248866 0.9185 -0.0884 0.0056 0.0141 PCYT2 TSS1500 chr17:79868687-79869811 Island cg13353733 -0.2669 0.0491 0.0465 0.0259 PDDC1 Body chr11:776803-777998 N_Shelf cg21913301 0.4221 -0.0387 0.0232 0.0451 PDE3A Body cg15091868 0.4254 -0.0337 0.0355 0.0469 PDE6B Body;Body;Body chr4:652665-652908 Island cg16879907 0.4701 -0.0355 0.0066 0.0351 PDE6D Body cg10661904 0.7365 -0.0678 0.0003 0.0019 PDE6G Body;Body chr17:79614850-79615559 S_Shelf TSS1500;TSS1500;TSS1500;TSS1500;TSS150 0;TSS1500;TSS1500;TSS1500;TSS1500;TSS15 00;TSS1500;TSS1500;TSS1500;TSS1500;TSS1 500;TSS1500;TSS1500;TSS1500;TSS1500;TSS cg08729135 0.7786 -0.0651 0.0254 0.0027 PDE9A 1500 chr21:44073201-44074650 Island cg20535794 1.0300 -0.0429 0.0218 0.0417 PDGFA Body;Body chr7:556611-562845 Island cg22268137 0.8634 -0.0607 0.0118 0.0306 PDX1 Body chr13:28498226-28499046 N_Shore cg20230182 0.6537 -0.0304 0.0301 0.0120 PDZD11 3'UTR chrX:69509644-69509962 N_Shelf

cg17182036 -0.5582 0.0338 0.0114 0.0499 PDZD8 Body cg21731345 -1.0024 0.0349 0.0380 0.0344 PEX11G TSS1500 chr19:7553699-7554033 S_Shore cg21812332 0.6680 -0.0421 0.0102 0.0309 PEX19 5'UTR;Body cg01058932 -0.1959 0.0308 0.0037 0.0094 PFKFB1 TSS1500 cg09274658 -0.4754 0.0478 0.0173 0.0430 PFKL Body;Body chr21:45730220-45730444 N_Shelf cg16324184 -0.4770 0.0304 0.0172 0.0125 PFKP Body cg02539829 -0.6612 0.0409 0.0278 0.0032 PGAP1 Body chr2:197791390-197791599 N_Shelf cg09938881 -0.3018 0.0353 0.0129 0.0182 PGBD5 3'UTR cg04746197 0.4421 -0.0404 0.0318 0.0156 PHLDA2 TSS1500 chr11:2949788-2951756 Island cg06040420 0.5850 -0.0333 0.0443 0.0117 PHOSPHO2 Body;5'UTR cg08062484 0.6446 -0.0411 0.0199 0.0362 PHOX2B 3'UTR chr4:41747508-41747944 Island cg06564473 0.4256 -0.0352 0.0208 0.0145 PHRF1 Body chr11:597465-597700 S_Shelf cg23666536 0.5605 -0.0325 0.0049 0.0163 PHTF1 3'UTR cg00339913 -0.1325 0.0333 0.0361 0.0278 PHYHIP Body;Body cg27179498 0.4297 -0.0321 0.0103 0.0291 PI4KA 3'UTR;3'UTR chr22:21056258-21058793 S_Shelf cg05674437 0.8609 -0.0306 0.0310 0.0020 PIGZ 5'UTR chr3:196693765-196694200 Island cg09706586 -0.8773 0.0604 0.0066 0.0071 PIK3CD Body chr1:9775708-9775997 Island cg23365392 -0.3370 0.0595 0.0046 0.0466 PILRA TSS1500;TSS1500;TSS1500 cg03747030 0.5435 -0.0319 0.0082 0.0314 PIP5K1C TSS1500 chr19:3699950-3700616 S_Shore cg14609960 1.0929 -0.0625 0.0299 0.0017 PITRM1 Body chr10:3180174-3180578 Island cg20146573 0.3622 -0.0308 0.0278 0.0498 PKIA 3'UTR;3'UTR cg13964781 0.6061 -0.0785 0.0255 0.0101 PKN1 Body;Body chr19:14551998-14552255 S_Shore cg01775379 -0.2088 0.0444 0.0107 0.0227 PKP4 5'UTR;5'UTR chr2:159313652-159314813 S_Shore cg04023204 -0.1680 0.0412 0.0024 0.0290 PLA2G15 Body chr16:68278870-68279628 S_Shelf cg04232541 0.9665 -0.0526 0.0295 0.0480 PLAGL1 5'UTR;5'UTR chr6:144384894-144385888 Island cg17168630 -0.2707 0.0404 0.0010 0.0187 PLAUR TSS1500;TSS1500;TSS1500 chr19:44172916-44173252 S_Shore cg14788049 0.6268 -0.0982 0.0264 0.0263 PLCB3 TSS1500 chr11:64018435-64019377 Island cg03819243 -0.4208 0.0624 0.0073 0.0487 PLCD1 TSS1500 chr3:38070394-38071598 S_Shore cg27638309 -0.4297 0.0679 0.0124 0.0217 PLCE1 Body;Body Body;Body;Body;Body;Body;Body;Body;Bod cg26120132 0.7555 -0.0669 0.0099 0.0174 PLEC1 y chr8:144990270-145002135 Island cg24492508 -0.7469 0.0442 0.0137 0.0062 PLEKHA5 5'UTR;Body cg23881613 -0.7422 0.0452 0.0140 0.0245 PLVAP 3'UTR chr19:17462721-17463137 Island

cg05961145 0.6153 -0.0449 0.0031 0.0154 PMFBP1 Body;Body cg00571700 -0.6609 0.0467 0.0184 0.0164 PNCK TSS1500 chrX:152938634-152939544 S_Shore cg18259342 0.3324 -0.0374 0.0207 0.0338 PNKD Body chr2:219187653-219188251 N_Shelf cg06484000 -0.3875 0.0399 0.0094 0.0404 PNMAL2 1stExon chr19:46996327-46998437 Island cg04683830 0.3372 -0.0385 0.0032 0.0248 PNPLA7 Body;Body chr9:140417626-140417856 N_Shore cg03417156 -0.2896 0.0346 0.0305 0.0225 PODNL1 Body;Body;Body chr19:14043645-14044211 Island cg16725944 -0.3158 0.0545 0.0021 0.0027 POLE Body cg10237599 0.6193 -0.0796 0.0221 0.0067 POLR2B Body chr4:57844857-57845202 S_Shore cg09851883 0.8038 -0.0397 0.0039 0.0116 POLR2K TSS200 cg06095296 -0.6511 0.0426 0.0051 0.0184 POLR3E Body chr16:22337148-22337576 N_Shore cg22985036 0.8891 -0.0812 0.0351 0.0271 POLS Body cg16927253 0.8210 -0.0314 0.0169 0.0371 POM121L2 TSS1500 chr6:27279794-27280635 Island cg02757179 -0.7119 0.0565 0.0428 0.0188 POMC Body;Body chr2:25383939-25384763 S_Shore cg03027774 0.5853 -0.0319 0.0312 0.0030 POP7 5'UTR chr7:100303014-100304079 Island cg24118856 -0.5384 0.0806 0.0479 0.0191 PPAN-P2RY11 Body;Body chr19:10224442-10225138 N_Shore cg16223079 -0.2741 0.0459 0.0397 0.0119 PPCDC Body cg08514558 0.2282 -0.0409 0.0046 0.0272 PPIF TSS1500 chr10:81107082-81107488 N_Shore cg11311280 -0.4326 0.0334 0.0006 0.0153 PPM1H Body cg24834740 0.7918 -0.0384 0.0343 0.0369 PPP1R16B 5'UTR chr20:37434206-37435592 Island cg14245239 -0.8161 0.0750 0.0239 0.0338 PPP1R1C Body cg11060379 -0.1389 0.0322 0.0210 0.0194 PPP1R2P1 Body chr6:32847498-32847846 Island cg22338118 -0.2910 0.0594 0.0029 0.0112 PPP1R9A TSS1500;TSS1500 chr7:94536849-94537477 N_Shore cg23473849 0.7663 -0.0560 0.0210 0.0379 PPP2R5B TSS200 chr11:64692060-64692496 Island cg17803298 0.5612 -0.0376 0.0109 0.0228 PPP5C TSS1500 chr19:46850185-46850678 N_Shore cg09939205 0.4650 -0.0374 0.0314 0.0321 PPPDE2 Body chr22:42016301-42017784 N_Shelf cg12626589 0.6743 -0.1178 0.0153 0.0085 PPT2 TSS1500;TSS1500;TSS1500 chr6:32121829-32122529 N_Shore cg25504749 0.9890 -0.1569 0.0080 0.0241 PRAP1 TSS1500;TSS1500 cg13152158 -0.6202 0.0548 0.0111 0.0015 PRDM16 Body;Body chr1:3147845-3148081 N_Shelf cg00848461 -0.5015 0.0677 0.0399 0.0089 PRELID1 Body;TSS1500;TSS1500 chr5:176730031-176731130 S_Shore cg00734018 0.7092 -0.0686 0.0132 0.0168 PRIC285 Body;Body chr20:62193966-62198985 Island cg07242375 1.1792 -0.0711 0.0064 0.0486 PRICKLE3 Body chrX:49042676-49043059 N_Shore cg18107623 -0.6902 0.0436 0.0019 0.0038 PRKAG2 Body;Body chr7:151479989-151480353 S_Shore cg18463891 0.5285 -0.0359 0.0218 0.0025 PRKAR1B Body;Body;Body;Body;Body;Body chr7:592620-593058 S_Shore

cg18025961 0.4600 -0.0369 0.0399 0.0033 PRKCZ Body;Body;Body cg09196146 0.7793 -0.0398 0.0349 0.0046 PRO1768 TSS200;5'UTR cg04685253 0.4492 -0.0497 0.0212 0.0155 PRR12 Body chr19:50119223-50119476 N_Shore cg27067781 -0.5964 0.0531 0.0100 0.0058 PRRT1 3'UTR chr6:32116590-32117229 Island cg13494826 -0.5575 0.0527 0.0070 0.0160 PRRX2 Body cg02256969 -0.6333 0.0616 0.0143 0.0177 PRSS22 TSS200 chr16:2907574-2907836 S_Shore cg07530759 -0.6930 0.0460 0.0419 0.0140 PRSS37 TSS1500 cg09970967 -0.4945 0.0851 0.0060 0.0345 PSEN1 TSS1500;TSS1500 chr14:73602898-73603747 N_Shore cg10778455 0.7429 -0.0523 0.0184 0.0364 PSMA2 3'UTR cg13610026 -0.2504 0.0449 0.0161 0.0106 PSMB7 Body cg13806767 0.5707 -0.0644 0.0277 0.0225 PSMD14 TSS1500 chr2:162164675-162165248 N_Shore cg00052482 -0.7864 0.1180 0.0081 0.0304 PSMD4 TSS1500 cg24054649 0.5649 -0.0305 0.0133 0.0446 PSME1 TSS1500;TSS1500 chr14:24605082-24605760 N_Shore cg13671374 0.4312 -0.0501 0.0176 0.0394 PSORS1C1 Body;Body cg06613515 -0.2600 0.0312 0.0082 0.0016 PSTPIP1 5'UTR;1stExon cg02348462 0.4373 -0.0475 0.0044 0.0416 PTBP1 Body;Body;Body;Body chr19:807131-807445 Island cg13974838 0.7354 -0.0543 0.0205 0.0172 PTCH1 Body;Body;Body;Body;Body;Body;Body cg00554604 0.9943 -0.0576 0.0038 0.0387 PTDSS2 Body chr11:460468-460715 Island cg13712952 0.8633 -0.0621 0.0042 0.0292 PTENP1 TSS1500 cg13853217 -0.8409 0.0734 0.0199 0.0129 PTGES3 3'UTR cg00028636 1.8420 -0.1413 0.0296 0.0296 PTMS Body chr12:6875481-6876923 Island cg02349739 -0.6756 0.0338 0.0090 0.0039 PTOV1 Body chr19:50353790-50355483 Island cg05394244 0.6303 -0.0648 0.0033 0.0134 PTP4A1 TSS1500 chr6:64282151-64283736 N_Shore cg15975802 -0.3565 0.0377 0.0400 0.0270 PTPN6 TSS1500 chr12:7053149-7053927 S_Shore cg01437204 0.6449 -0.0418 0.0229 0.0160 PTPN7 TSS1500;TSS1500 cg00086113 -0.4018 0.0384 0.0011 0.0255 PTPN9 3'UTR cg13382703 -0.8637 0.0444 0.0297 0.0304 PTPRF Body;Body chr1:44056755-44057179 Island cg24389102 1.1078 -0.0455 0.0103 0.0172 PTPRK Body;Body cg10225197 0.6936 -0.0621 0.0003 0.0002 PTPRN Body;TSS1500 chr2:220159438-220159977 Island cg25120425 0.5207 -0.0433 0.0218 0.0058 PTPRN2 Body;Body;Body cg23836612 -0.5591 0.0350 0.0115 0.0179 PUS1 Body;Body;Body chr12:132413338-132414801 S_Shelf cg25328384 -0.3633 0.0540 0.0479 0.0113 PVR 3'UTR;3'UTR;3'UTR cg14094027 -0.7737 0.1066 0.0398 0.0343 PXN 5'UTR;Body;Body

cg09587549 -0.3921 0.0424 0.0051 0.0427 PYCARD 5'UTR;1stExon;5'UTR;1stExon chr16:31213566-31214287 Island cg13532359 0.3816 -0.0332 0.0007 0.0053 QSOX2 Body cg16352485 0.7997 -0.0520 0.0261 0.0484 RAB11FIP3 Body;Body chr16:532467-532669 Island cg10892375 -0.8824 0.0428 0.0320 0.0430 RAB2B Body;Body;TSS1500;TSS200 chr14:21944914-21945812 N_Shore cg19404781 0.8502 -0.0423 0.0309 0.0394 RAB3GAP2 Body;Body cg07476963 0.6069 -0.0514 0.0021 0.0177 RABGAP1L TSS1500 chr1:174128296-174129289 N_Shore cg21131421 0.5510 -0.0419 0.0139 0.0445 RAD51L1 Body;Body;Body cg01718580 -0.5133 0.0442 0.0226 0.0109 RAET1G Body chr6:150243902-150244210 N_Shore cg08631427 1.1324 -0.0874 0.0019 0.0342 RAET1L TSS200 cg11778749 1.2123 -0.1318 0.0004 0.0060 RAGE TSS1500 chr14:102771116-102771718 S_Shore cg10870160 0.3065 -0.0401 0.0353 0.0262 RAI1 5'UTR chr17:17697710-17698063 N_Shelf cg03291819 -0.4037 0.0375 0.0349 0.0146 RAI2 5'UTR chrX:17878441-17878888 N_Shelf cg20842915 0.7054 -0.0972 0.0183 0.0143 RALA 5'UTR chr7:39662543-39663792 S_Shore cg03562117 0.5166 -0.0311 0.0040 0.0151 RALYL Body;Body;Body;Body cg06293049 0.5473 -0.0406 0.0280 0.0457 RARG 5'UTR chr12:53625629-53625993 N_Shelf cg10626896 0.5030 -0.0363 0.0474 0.0019 RASA3 Body chr13:114813942-114814457 N_Shelf cg23525051 0.7310 -0.0379 0.0141 0.0446 RASGRP1 Body;Body chr15:38856262-38857658 N_Shelf cg14750543 0.6140 -0.0438 0.0027 0.0093 RASSF2 Body;Body cg02035751 -0.2142 0.0465 0.0090 0.0316 RASSF5 Body;TSS1500;Body chr1:206730397-206730908 N_Shore cg08646051 0.9353 -0.0523 0.0205 0.0065 RASSF8 5'UTR;5'UTR;5'UTR;5'UTR;1stExon cg13911392 0.6584 -0.0478 0.0068 0.0304 RAVER1 TSS1500;Body chr19:10443688-10446022 Island cg27222157 0.5105 -0.0379 0.0016 0.0217 RBM14 TSS1500 chr11:66383571-66385047 N_Shore cg13172905 0.9124 -0.0608 0.0216 0.0318 RBPMS Body;Body;Body;Body cg05523906 -0.6464 0.0400 0.0082 0.0067 RCC2 Body;Body cg15836710 -0.5289 0.0412 0.0247 0.0382 RDBP Body chr6:31926489-31926940 N_Shelf cg18628371 0.3559 -0.0363 0.0285 0.0157 REC8 TSS200;TSS200 chr14:24641053-24642220 Island cg20880031 0.9758 -0.0653 0.0036 0.0483 RELN TSS1500;TSS1500 chr7:103629525-103630652 S_Shore cg01295673 0.5931 -0.0491 0.0488 0.0077 RFC5 TSS1500;TSS1500;TSS1500;TSS1500 chr12:118454391-118454996 N_Shore cg09690219 -0.6165 0.0463 0.0188 0.0214 RFXAP Body chr13:37393213-37394092 S_Shelf cg23889610 0.8480 -0.0559 0.0188 0.0394 RGL1 Body cg05876591 0.6037 -0.0491 0.0450 0.0332 RGL2 Body;Body chr6:33266302-33267582 N_Shore cg00415704 -0.2734 0.0412 0.0004 0.0056 RGMA Body;5'UTR chr15:93631428-93633173 N_Shore cg19111287 -0.2731 0.0397 0.0027 0.0146 RGS12 Body;Body;Body chr4:3374733-3374998 N_Shore

cg15452973 0.9107 -0.0550 0.0015 0.0237 RGS22 Body chr8:101117922-101118693 N_Shelf cg21219268 0.3986 -0.0352 0.0492 0.0452 RGS3 Body;Body;Body cg11093040 1.2495 -0.1208 0.0387 0.0131 RHBDD1 5'UTR;5'UTR chr2:227700313-227701115 S_Shore cg17284809 1.1575 -0.0477 0.0111 0.0111 RHBDL3 Body chr17:30593198-30594033 S_Shore cg06216293 -0.2740 0.0416 0.0171 0.0198 RHBG Body;Body chr1:156338758-156339251 Island cg05939380 -0.6434 0.0808 0.0019 0.0317 RHCG Body chr15:90029931-90030328 Island cg09618778 0.1766 -0.0329 0.0448 0.0464 RHOD Body chr11:66838918-66839192 Island cg20599295 1.0547 -0.1502 0.0422 0.0446 RILPL1 Body cg15811568 -0.7863 0.0796 0.0191 0.0397 RIMBP2 Body chr12:130908777-130909191 N_Shelf cg26099432 0.6416 -0.0583 0.0467 0.0135 RIMS1 Body;Body;Body;Body;Body;Body cg19702383 0.8605 -0.0880 0.0054 0.0462 RMST Body;TSS200 cg03117412 -0.7284 0.0576 0.0449 0.0293 RNASEH1 Body chr2:3605489-3606332 N_Shore cg07222133 0.7963 -0.0423 0.0062 0.0456 RNF130 TSS1500 chr5:179498291-179499338 S_Shore cg03166236 -0.6073 0.0434 0.0271 0.0499 RNF144A 5'UTR chr2:7057530-7058433 S_Shelf cg08521800 1.0150 -0.0604 0.0277 0.0444 RNF180 5'UTR;5'UTR chr5:63461448-63462106 S_Shore cg23782719 0.7720 -0.0433 0.0130 0.0114 RNF182 Body;Body;Body;Body cg21210232 0.7799 -0.1326 0.0482 0.0327 RNF207 Body chr1:6268820-6269588 N_Shore cg21231302 -0.2975 0.0374 0.0367 0.0203 RNF208 TSS1500 chr9:140115986-140118466 Island cg12852872 -0.5317 0.0412 0.0142 0.0066 RNF213 Body;Body cg20160729 -0.6071 0.0646 0.0095 0.0109 RNF216 Body;Body cg01209655 -0.4754 0.0303 0.0080 0.0124 RNF39 Body;Body chr6:30042918-30043500 N_Shore 5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UTR;5'UT cg15661311 0.5878 -0.0446 0.0006 0.0131 RNH1 R;5'UTR chr11:504189-504659 Island cg16047663 1.6119 -0.0845 0.0023 0.0173 RNPEP 3'UTR cg11080651 -0.4705 0.0346 0.0134 0.0048 ROPN1L Body chr5:10441605-10442512 S_Shelf cg02458188 -0.3590 0.0305 0.0371 0.0288 RORA Body cg24741392 0.9960 -0.0392 0.0027 0.0172 RPGR Body;Body chrX:38186422-38187010 Island cg13829638 -0.3569 0.0539 0.0154 0.0032 RPL35 Body chr9:127623557-127624486 N_Shelf cg09867945 -0.1481 0.0306 0.0297 0.0392 RPS10P7 Body cg20486651 0.6383 -0.0901 0.0347 0.0271 RPS6KA2 Body cg03043406 0.8000 -0.0869 0.0433 0.0012 RPS8 Body;TSS1500 chr1:45241013-45241900 S_Shore cg15946337 0.6741 -0.0464 0.0401 0.0116 RPTOR Body;Body chr17:78775591-78775815 N_Shelf cg26417554 0.5357 -0.0792 0.0236 0.0321 RPUSD3 TSS1500;TSS1500 chr3:9885512-9885780 S_Shore

cg21534309 0.3974 -0.0422 0.0061 0.0430 RSF1 Body cg01625761 -0.7109 0.0474 0.0054 0.0186 RTN4IP1 Body cg11504646 0.6853 -0.0468 0.0414 0.0284 RTP1 TSS1500 chr3:186917411-186917756 N_Shelf cg02767634 -0.3567 0.0433 0.0025 0.0195 RUFY1 3'UTR;3'UTR;3'UTR cg10475689 -0.2527 0.0472 0.0232 0.0091 RUNDC2A Body cg22234962 -0.7459 0.0356 0.0256 0.0247 RUSC1 5'UTR;5'UTR;5'UTR chr1:155292469-155295433 N_Shore cg23519671 0.9964 -0.1102 0.0413 0.0333 RYR1 Body;Body chr19:39009876-39010142 S_Shore cg10725912 0.5991 -0.0435 0.0204 0.0198 RYR3 Body cg17421062 -0.2031 0.0398 0.0028 0.0308 S100A7 5'UTR cg10297473 0.4923 -0.0542 0.0014 0.0060 SALL1 Body;5'UTR chr16:51183699-51188763 Island cg03712816 0.6140 -0.0444 0.0398 0.0075 SALL3 Body chr18:76737005-76741244 Island cg06036236 -0.6251 0.0612 0.0308 0.0191 SAMD11 Body chr1:869332-871872 S_Shore cg27512513 0.7861 -0.0365 0.0036 0.0346 SAMD12 Body cg21483922 0.5991 -0.0580 0.0114 0.0201 SAMD14 5'UTR chr17:48206663-48207601 N_Shore cg09274864 -0.5047 0.0319 0.0002 0.0051 SAMD4A Body;Body;Body chr14:55226963-55227200 Island cg07224310 -0.4548 0.0346 0.0074 0.0368 SAPS2 Body chr22:50862756-50862967 Island cg12465490 -0.4377 0.0421 0.0437 0.0354 SARS 3'UTR cg26131754 0.7121 -0.0317 0.0410 0.0093 SATB1 TSS1500;5'UTR chr3:18467440-18467664 Island cg14736108 0.4664 -0.0320 0.0275 0.0117 SBK2 1stExon chr19:56047403-56047668 Island cg18693051 -0.2812 0.0334 0.0078 0.0045 SBNO2 5'UTR chr19:1163466-1163876 N_Shore cg22303442 0.5402 -0.0436 0.0144 0.0401 SCARA5 Body chr8:27737077-27737289 N_Shelf cg05131292 0.5891 -0.0329 0.0398 0.0143 SCARNA3 Body;Body;Body cg27585618 0.5509 -0.0369 0.0379 0.0470 SCML4 5'UTR cg15422644 -0.3370 0.0389 0.0424 0.0451 SCN8A Body chr12:52115410-52115679 S_Shore cg14836522 0.1938 -0.0328 0.0047 0.0058 SDC3 Body cg12242474 -0.4777 0.0754 0.0412 0.0140 SDCBP2 Body;Body chr20:1293681-1294328 Island cg23956499 -0.6194 0.0528 0.0364 0.0101 SDCCAG8 Body chr1:243637639-243638142 N_Shelf cg20871445 0.7884 -0.0339 0.0094 0.0202 SDF4 5'UTR;5'UTR;TSS1500 chr1:1167001-1168985 N_Shore cg26275264 0.2884 -0.0362 0.0000 0.0014 SDK1 Body;Body cg26261291 -0.5906 0.0571 0.0221 0.0070 SDK2 Body chr17:71431621-71431878 S_Shelf cg13855364 0.3372 -0.0365 0.0115 0.0308 SEC16A 3'UTR chr9:139332839-139334501 S_Shore cg03322752 -0.7205 0.0631 0.0494 0.0213 SEC61G Body;Body chr7:54826581-54827188 N_Shelf cg06093460 0.4360 -0.0316 0.0036 0.0086 SELE 5'UTR

cg22927302 -0.1967 0.0391 0.0105 0.0215 SEMA3B TSS1500;TSS1500 cg11016195 0.7477 -0.0490 0.0130 0.0468 SEMA5A 5'UTR cg18419070 -0.8618 0.0449 0.0335 0.0490 SEMA5B Body cg01791648 0.3298 -0.0473 0.0266 0.0158 SENP7 TSS1500;TSS1500 chr3:101231610-101232173 S_Shore cg02506716 1.2046 -0.1717 0.0047 0.0044 SEPT10 Body;Body chr2:110370906-110373301 N_Shore cg07429284 0.5512 -0.0433 0.0273 0.0431 SEPT8 Body;5'UTR;Body;Body cg00817885 0.6595 -0.0490 0.0122 0.0350 SERPINA7 TSS1500 cg17330652 0.6796 -0.0323 0.0391 0.0483 SERPINC1 5'UTR;1stExon cg23007535 0.4163 -0.0364 0.0158 0.0129 SETD2 Body cg22885062 0.4399 -0.0402 0.0444 0.0436 SF1 Body;Body;Body chr11:64532936-64533763 Island cg20822858 1.4276 -0.0757 0.0018 0.0225 SGK1 Body;TSS1500 chr6:134497536-134497756 S_Shore cg18378817 -0.5493 0.0565 0.0041 0.0281 SGTA 3'UTR chr19:2757566-2757856 N_Shore cg07647796 0.8366 -0.0863 0.0022 0.0294 SH2B1 Body;Body;Body;Body;Body cg22633936 -0.3537 0.0511 0.0217 0.0235 SH2D4B Body;1stExon;5'UTR cg13415795 -0.4899 0.0572 0.0028 0.0375 SH2D7 3'UTR cg08222309 0.4810 -0.0535 0.0479 0.0094 SH3BGRL TSS1500;5'UTR cg04493432 0.5171 -0.0721 0.0059 0.0435 SH3TC1 5'UTR cg13018402 0.6225 -0.0554 0.0131 0.0071 SH3TC2 TSS1500 cg00646241 0.6133 -0.0806 0.0106 0.0449 SHANK2 Body chr11:70563664-70563886 Island cg03193168 0.2453 -0.0451 0.0001 0.0044 SHANK3 Body chr22:51158386-51160060 Island cg17833341 0.7037 -0.0357 0.0415 0.0112 SHC1 TSS1500;TSS1500;Body;Body chr1:154946742-154947486 Island cg24736471 0.8292 -0.0585 0.0234 0.0186 SHC4 Body;1stExon;3'UTR chr15:49170144-49170710 S_Shore cg23704066 1.4204 -0.0317 0.0024 0.0294 SHFM1 1stExon chr7:96338816-96339277 Island cg02852989 0.5680 -0.0309 0.0050 0.0164 SHISA7 TSS1500 chr19:55953371-55954641 S_Shore Body;Body;Body;Body;Body;Body;Body;Bod cg19535267 0.7615 -0.0652 0.0041 0.0003 SHMT2 y chr12:57623420-57623903 S_Shore cg21433933 -0.3329 0.0526 0.0217 0.0105 SHROOM1 TSS1500 chr5:132160904-132161809 S_Shore cg24592906 1.1882 -0.1613 0.0299 0.0052 SIM1 1stExon;5'UTR chr6:100912071-100913337 N_Shore cg02194789 0.6460 -0.0946 0.0043 0.0140 SIM2 Body;Body chr21:38068193-38073891 S_Shore cg00328376 0.7195 -0.0578 0.0484 0.0388 SKAP2 Body chr7:26903869-26904753 N_Shore cg07574267 0.5057 -0.0327 0.0033 0.0300 SKI 3'UTR chr1:2236442-2239069 Island cg24521988 -0.7012 0.0478 0.0039 0.0077 SKIV2L Body chr6:31926489-31926940 S_Shore cg04656051 -0.2743 0.0313 0.0320 0.0052 SLC11A1 Body chr2:219252421-219252631 Island

cg27585120 0.6959 -0.0357 0.0028 0.0025 SLC12A7 Body chr5:1077844-1078056 N_Shore cg00087274 -0.3397 0.0393 0.0071 0.0114 SLC12A8 Body chr3:124860569-124861019 N_Shelf cg13261725 0.5391 -0.0401 0.0284 0.0167 SLC17A4 5'UTR cg27083019 0.4072 -0.0300 0.0391 0.0453 SLC17A7 TSS1500 chr19:49946345-49947222 N_Shore cg10385290 1.0263 -0.0686 0.0086 0.0302 SLC1A6 TSS200 cg12439773 -0.2336 0.0449 0.0460 0.0434 SLC22A6 1stExon;1stExon;1stExon;1stExon cg22177795 -0.6865 0.0388 0.0104 0.0214 SLC23A2 5'UTR;TSS200 cg18467110 0.6348 -0.0393 0.0220 0.0429 SLC25A36 Body;Body chr3:140660334-140661602 Island cg14218435 0.4915 -0.0764 0.0295 0.0203 SLC26A9 Body;Body;Body cg02114341 0.5019 -0.0455 0.0121 0.0004 SLC29A3 Body chr10:73078857-73079181 S_Shelf cg23338195 0.8783 -0.0690 0.0484 0.0013 SLC30A8 TSS1500 cg05936441 0.5690 -0.0313 0.0107 0.0472 SLC32A1 Body chr20:37352130-37357372 Island cg18492059 0.4337 -0.0405 0.0071 0.0430 SLC38A5 TSS1500 cg19805748 -0.1476 0.0391 0.0426 0.0001 SLC39A11 Body;Body cg19668951 0.8967 -0.0733 0.0235 0.0103 SLC39A13 5'UTR;5'UTR chr11:47429733-47430346 S_Shore cg16061354 0.4985 -0.0367 0.0279 0.0389 SLC43A2 Body chr17:1531110-1533229 N_Shelf cg07067982 -0.8366 0.0467 0.0231 0.0111 SLC43A3 5'UTR;5'UTR;1stExon;5'UTR chr11:57194340-57194650 Island cg00087735 -0.6701 0.0321 0.0317 0.0097 SLC45A1 Body chr1:8390202-8390800 Island cg03426615 0.7251 -0.0707 0.0491 0.0395 SLC4A2 Body cg02523679 -0.2700 0.0525 0.0028 0.0280 SLC6A13 TSS1500 cg02830714 0.5256 -0.0549 0.0402 0.0451 SLC6A18 Body chr5:1232352-1232594 Island cg10778996 0.8250 -0.0475 0.0112 0.0430 SLC7A1 Body cg15070897 -0.5713 0.0372 0.0019 0.0356 SLC7A7 5'UTR;1stExon;5'UTR;5'UTR cg11282353 -0.3798 0.0463 0.0016 0.0283 SLCO2A1 Body cg20018563 -0.2624 0.0403 0.0062 0.0075 SLCO3A1 Body;Body cg20421928 0.8586 -0.1050 0.0106 0.0390 SLIT3 Body cg04642759 1.9774 -0.1824 0.0165 0.0362 SLITRK2 TSS1500;TSS1500;TSS1500;TSS1500 chrX:144899363-144900266 N_Shore cg05720429 1.3079 -0.0644 0.0000 0.0001 SMARCA5 Body chr4:144434249-144435343 S_Shore cg05311180 0.5944 -0.0491 0.0124 0.0446 SMARCAL1 Body;Body cg17154187 2.6986 -0.0481 0.0103 0.0280 SMCR7 TSS200;TSS1500;TSS200 chr17:18163685-18164672 Island cg06745378 0.7634 -0.0552 0.0456 0.0265 SMEK2 Body;Body chr2:55844267-55845065 N_Shelf cg02873263 -0.5323 0.0553 0.0260 0.0181 SMOC1 Body;Body cg02922084 -0.4653 0.0582 0.0350 0.0232 SMOC2 Body;Body

cg06768213 -0.5705 0.0675 0.0087 0.0228 SNAP47 Body cg12634276 0.6084 -0.0333 0.0362 0.0307 SNORA26 TSS1500;TSS1500 chr4:53578358-53579238 N_Shore cg16050237 0.6515 -0.0364 0.0283 0.0361 SNORD115-10 TSS1500;TSS1500 cg07664976 0.6520 -0.0366 0.0488 0.0454 SNORD116-26 TSS200 cg27122942 0.9656 -0.0366 0.0171 0.0220 SNORD15A TSS1500;TSS200 chr11:75110493-75110924 N_Shore cg00821444 0.9061 -0.0588 0.0078 0.0189 SNORD34 TSS200;Body;TSS1500;Body chr19:49990435-49990965 S_Shelf cg03557725 -0.4899 0.0836 0.0019 0.0252 SNRPF TSS1500 chr12:96252020-96252246 N_Shore cg11164993 1.2884 -0.0615 0.0408 0.0402 SNX12 TSS1500 chrX:70287890-70288359 S_Shore cg27081230 0.8179 -0.0591 0.0052 0.0411 SNX20 TSS1500;TSS1500;TSS1500 cg14135783 0.8513 -0.0681 0.0030 0.0165 SNX8 Body chr7:2318238-2319079 Island cg05761277 0.6572 -0.0396 0.0233 0.0054 SOCS3 TSS1500 chr17:76354818-76357038 Island cg09190795 -0.5096 0.0671 0.0138 0.0115 SOLH 5'UTR chr16:587567-588172 N_Shelf cg27312979 -0.2097 0.0351 0.0125 0.0494 SORBS1 Body;Body;Body;Body;Body;Body;Body cg04928457 0.4411 -0.0430 0.0052 0.0074 SORBS2 5'UTR cg25606172 0.7926 -0.0632 0.0036 0.0019 SORCS2 Body cg26807939 0.6978 -0.0510 0.0320 0.0391 SOX14 TSS1500 chr3:137482964-137484454 Island cg22530053 1.2155 -0.0577 0.0102 0.0352 SOX2OT Body;TSS1500 chr3:181430141-181431076 N_Shore cg08625851 0.4871 -0.0327 0.0024 0.0020 SOX4 TSS200 chr6:21594613-21596437 N_Shore cg14242042 0.8169 -0.0447 0.0349 0.0369 SOX5 5'UTR chr12:24714956-24716243 Island cg26516680 1.1742 -0.0599 0.0140 0.0103 SPAG17 Body cg26845278 -0.6252 0.0573 0.0294 0.0087 SPATA21 1stExon;5'UTR chr1:16766998-16767803 N_Shelf cg10202436 0.6902 -0.1085 0.0446 0.0159 SPATA24 Body chr5:138727710-138730911 S_Shelf cg06029050 0.6374 -0.0319 0.0101 0.0382 SPCS2 1stExon;TSS200 chr11:74659931-74660373 S_Shore cg20456243 0.5421 -0.0576 0.0469 0.0022 SPEG Body chr2:220348955-220349784 S_Shelf cg17041861 0.7746 -0.0402 0.0004 0.0075 SPIRE1 5'UTR;Body;Body chr18:12657044-12658727 N_Shelf cg22453911 0.3732 -0.0421 0.0067 0.0257 SPPL2B 3'UTR;3'UTR chr19:2354289-2354560 Island cg20410997 0.6440 -0.0320 0.0171 0.0458 SPRY4 TSS1500;TSS1500 chr5:141705391-141705688 N_Shore cg10912634 -0.8632 0.0737 0.0042 0.0373 SRA1 3'UTR chr5:139927157-139927491 S_Shelf cg03641529 0.7570 -0.0676 0.0190 0.0311 SREBF1 Body;Body chr17:17715696-17716219 Island cg18278184 0.5668 -0.0561 0.0109 0.0334 SRGN TSS1500 cg07166266 -0.3846 0.0461 0.0087 0.0420 SRP68 Body chr17:74068174-74068756 N_Shore cg18034259 0.4110 -0.0477 0.0128 0.0099 SRRM3 Body chr7:75896510-75896944 S_Shore cg25240254 -0.3232 0.0518 0.0457 0.0035 SSC5D Body chr19:56000722-56001026 Island

cg07700680 0.6151 -0.0328 0.0488 0.0392 SSH1 Body;Body;Body cg22537597 -0.2331 0.0467 0.0152 0.0122 SSPO 3'UTR cg14757173 -0.1642 0.0357 0.0017 0.0249 SSTR3 3'UTR chr22:37603001-37603753 N_Shore cg02231767 0.6505 -0.0533 0.0166 0.0148 ST18 5'UTR cg14640789 0.6883 -0.0506 0.0008 0.0081 ST3GAL1 Body;Body cg07929956 0.6318 -0.0440 0.0165 0.0355 ST3GAL2 5'UTR cg13338207 0.5035 -0.0336 0.0440 0.0072 ST3GAL6 5'UTR chr3:98451286-98452225 S_Shore cg17653583 -0.8700 0.0557 0.0208 0.0481 ST7OT3 TSS1500;Body;Body cg20723302 0.5480 -0.0331 0.0000 0.0028 STAP1 TSS1500 cg24997845 0.6371 -0.0333 0.0026 0.0162 STAT1 5'UTR;5'UTR chr2:191878608-191879253 N_Shore cg17587998 0.5229 -0.0318 0.0336 0.0429 STK19 TSS1500;TSS1500;TSS1500;Body chr6:31939730-31940559 N_Shore cg09124518 1.2114 -0.1088 0.0007 0.0159 STK32C Body chr10:134120447-134122422 N_Shore cg24110635 0.5119 -0.0459 0.0065 0.0123 STK38L Body cg23917779 -0.5303 0.0783 0.0071 0.0100 STK40 Body chr1:36807362-36807584 Island cg15527491 0.9394 -0.0887 0.0151 0.0007 STMN1 Body;Body;Body;Body chr1:26231950-26233624 N_Shelf cg18628646 0.3773 -0.0481 0.0365 0.0390 STOX2 Body cg04798930 1.0083 -0.0497 0.0037 0.0286 STRN Body chr2:37193131-37194287 N_Shore cg03602730 0.8543 -0.0414 0.0171 0.0297 STXBP5L TSS200 chr3:120626880-120627579 Island cg23124755 0.5650 -0.0309 0.0018 0.0051 SUGT1P1 Body;1stExon chr9:33447446-33447824 Island cg24069221 -0.3779 0.0562 0.0227 0.0357 SUMO4 3'UTR;Body;1stExon cg08739188 0.5739 -0.0492 0.0338 0.0314 SV2C TSS1500 chr5:75377898-75378189 N_Shore cg22439459 0.3694 -0.0375 0.0218 0.0188 SVOPL Body;Body chr7:138348962-138349444 N_Shelf cg09105523 -0.4816 0.0307 0.0236 0.0100 SYCP2L Body chr6:10887184-10887622 S_Shore cg01513802 0.5088 -0.0378 0.0049 0.0356 SYNE1 Body;5'UTR;Body;Body cg14008998 0.6803 -0.0529 0.0493 0.0166 SYNE2 Body;Body cg00789347 0.7254 -0.0744 0.0077 0.0325 SYNGR3 TSS1500 chr16:2040034-2040628 N_Shore cg27550918 0.2709 -0.0384 0.0228 0.0425 SYNPO2L 1stExon;5'UTR;Body chr10:75407413-75407706 S_Shelf cg04013592 0.4621 -0.0400 0.0032 0.0207 SYNPR TSS1500 chr3:63263989-63264205 N_Shore cg18176363 0.6146 -0.0492 0.0343 0.0101 SYT1 Body;Body;Body cg24720849 -0.9362 0.1423 0.0112 0.0449 SYT8 TSS1500 Body;TSS1500;TSS1500;Body;TSS1500;Body cg17007339 1.3021 -0.0915 0.0024 0.0166 SYTL2 ;Body;Body cg08036278 -0.8924 0.0453 0.0106 0.0254 SYVN1 TSS1500;TSS1500 chr11:64901526-64902107 S_Shore

cg22186380 -0.2649 0.0404 0.0015 0.0078 TAAR2 Body;TSS1500 cg00554413 0.4207 -0.0418 0.0175 0.0368 TACSTD2 1stExon chr1:59042013-59043295 Island 5'UTR;TSS200;1stExon;TSS200;TSS200;1stEx cg18624274 -0.8776 0.0406 0.0416 0.0344 TADA3 on;5'UTR chr3:9833992-9834985 Island cg18266257 -0.5572 0.0597 0.0109 0.0009 TAP2 Body;Body chr6:32806284-32806669 N_Shelf cg18930100 0.6305 -0.0401 0.0017 0.0302 TAPBP Body;Body;Body chr6:33281112-33281827 N_Shore cg04615639 -0.7730 0.0955 0.0051 0.0361 TBC1D16 5'UTR chr17:77997723-77997951 Island cg13689390 -0.5701 0.0346 0.0326 0.0363 TBC1D2 Body chr9:101017382-101018581 N_Shelf cg01008267 -0.6148 0.0629 0.0002 0.0073 TBC1D22A Body chr22:47513202-47513585 S_Shore cg01850334 0.5876 -0.0402 0.0019 0.0228 TBC1D8 Body cg22736682 -0.4487 0.0331 0.0465 0.0005 TBCB Body chr19:36612342-36612932 S_Shore cg07114009 -0.4482 0.0409 0.0261 0.0048 TBCD Body;TSS200 cg09728865 -0.2161 0.0421 0.0063 0.0154 TBL1Y 5'UTR;5'UTR;5'UTR chrY:6778574-6780028 Island cg24710073 0.3020 -0.0482 0.0058 0.0351 TBP 5'UTR chr6:170862124-170862480 S_Shore cg06797808 1.1092 -0.1017 0.0037 0.0093 TBX10 Body chr11:67396844-67398294 S_Shelf cg00598758 0.5191 -0.0438 0.0335 0.0138 TBX20 Body;Body chr7:35292985-35294674 N_Shore cg03559073 -0.4802 0.0398 0.0169 0.0461 TBX5 Body;Body;Body;Body chr12:114833911-114834210 N_Shore cg14179628 -0.3776 0.0523 0.0134 0.0106 TCEAL7 TSS1500 cg14047630 -0.2410 0.0405 0.0132 0.0046 TCERG1L Body cg04129308 0.3398 -0.0342 0.0017 0.0228 TCF21 3'UTR chr6:134216919-134217280 N_Shore cg13484329 -0.2248 0.0527 0.0173 0.0212 TCHP Body;Body cg03928812 0.6383 -0.0424 0.0290 0.0318 TCN1 TSS1500 cg27547703 0.7871 -0.0602 0.0128 0.0495 TDRD1 TSS200 chr10:115938962-115939292 Island cg09191594 0.6404 -0.0339 0.0473 0.0258 TDRD9 Body cg11777321 0.9181 -0.0385 0.0280 0.0095 TEF Body;Body chr22:41777430-41778281 S_Shore cg12888231 0.5148 -0.0334 0.0344 0.0145 TESC Body;Body;Body chr12:117484305-117484627 Island cg05798717 0.5681 -0.0457 0.0165 0.0280 TFAP2D Body chr6:50682334-50683214 S_Shore cg24685006 1.4017 -0.0462 0.0111 0.0040 TFAP2E Body chr1:36042432-36043444 Island cg09410308 1.2737 -0.0972 0.0112 0.0027 TFF2 3'UTR cg04806409 -0.2208 0.0376 0.0264 0.0289 TFF3 1stExon cg21778644 -0.8212 0.0513 0.0022 0.0203 TGFBRAP1 Body;Body cg23278885 -0.4847 0.0702 0.0475 0.0435 TGM6 TSS200 cg16929107 -1.0441 0.0440 0.0297 0.0091 TGOLN2 Body chr2:85554134-85555414 Island

cg17499251 1.0864 -0.1164 0.0061 0.0292 THEG Body;Body chr19:375830-376094 N_Shelf cg01075002 0.6198 -0.0517 0.0344 0.0373 TIAM2 Body cg17639290 0.4836 -0.0306 0.0159 0.0325 TIMM8B Body;TSS1500;Body chr11:111957352-111957681 N_Shore cg08479319 -0.4195 0.0335 0.0018 0.0079 TIPIN 5'UTR chr15:66648784-66649178 Island cg22696612 -0.2750 0.0580 0.0477 0.0254 TKTL1 Body;Body chrX:153523741-153524175 S_Shelf cg07015886 -0.3155 0.0629 0.0332 0.0092 TLR5 TSS1500 chr1:223316185-223316689 S_Shore cg07792815 0.4892 -0.0358 0.0411 0.0195 TMC5 Body;Body;Body cg24867468 0.9584 -0.1255 0.0069 0.0202 TMC6 3'UTR;3'UTR cg04947157 -0.3484 0.0360 0.0231 0.0162 TMC8 Body;5'UTR;1stExon chr17:76127521-76128406 S_Shore cg17853801 -0.3271 0.0438 0.0125 0.0187 TMEM11 Body;Body cg23406136 0.2677 -0.0324 0.0386 0.0054 TMEM115 TSS1500 chr3:50396347-50397175 S_Shore cg08386165 -0.7847 0.0395 0.0062 0.0309 TMEM126B Body cg15328703 0.5570 -0.0375 0.0096 0.0032 TMEM132B 3'UTR cg16533379 0.5180 -0.0351 0.0004 0.0043 TMEM132D Body cg10265365 -0.2802 0.0457 0.0335 0.0442 TMEM145 Body chr19:42827743-42829149 N_Shore cg12331160 -0.5031 0.0536 0.0047 0.0326 TMEM163 Body cg00197026 0.5390 -0.0359 0.0159 0.0030 TMEM170B TSS1500 chr6:11537537-11538929 N_Shore cg25921357 0.3965 -0.0316 0.0080 0.0326 TMEM190 TSS1500 chr19:55889005-55889476 N_Shore cg13370852 -0.2664 0.0404 0.0286 0.0164 TMEM201 Body;Body chr1:9648586-9649517 S_Shelf cg18811916 0.6330 -0.0310 0.0050 0.0457 TMEM33 3'UTR cg09888231 0.6071 -0.0377 0.0079 0.0374 TMEM39B TSS1500 chr1:32538205-32539052 N_Shore cg07908984 -0.5253 0.0387 0.0211 0.0250 TMEM40 TSS200 cg26027853 -0.4899 0.0368 0.0084 0.0401 TMEM51 5'UTR;5'UTR;5'UTR;5'UTR chr1:15541181-15541447 Island cg18507018 -0.9024 0.0598 0.0026 0.0229 TMEM55A Body cg18883198 0.7807 -0.0671 0.0036 0.0438 TMEM57 Body chr1:25756470-25758115 S_Shore cg06346993 -0.7583 0.0815 0.0004 0.0120 TMEM63B TSS1500;5'UTR chr6:44094708-44096134 N_Shore cg16605187 0.4035 -0.0364 0.0227 0.0033 TMEM79 TSS1500;5'UTR;1stExon cg22452236 0.6567 -0.0350 0.0025 0.0197 TMEM90B TSS200 chr20:24449844-24452037 N_Shore cg13011901 0.5813 -0.0348 0.0074 0.0052 TMIE 3'UTR cg03929575 -0.9058 0.0696 0.0295 0.0036 TMTC1 Body cg03406844 0.5336 -0.0408 0.0222 0.0475 TNFAIP6 Body cg05503460 -0.5142 0.0358 0.0217 0.0201 TNFAIP8L3 Body chr15:51387532-51387755 Island cg20682376 -0.4550 0.0317 0.0106 0.0206 TNFRSF13B TSS200

Body;Body;Body;Body;Body;Body;Body;Bod cg26089892 0.5487 -0.0303 0.0230 0.0100 TNIK y;Body cg22178392 0.6786 -0.0409 0.0032 0.0264 TNIP1 5'UTR chr5:150460086-150460864 N_Shore cg02132728 -0.4004 0.0406 0.0043 0.0123 TNIP2 Body;5'UTR chr4:2757653-2758010 N_Shore cg22941315 0.6445 -0.0657 0.0291 0.0114 TNR 5'UTR cg02825561 0.8411 -0.0517 0.0232 0.0300 TNRC18 Body chr7:5395872-5396300 Island cg13154622 -0.3399 0.0387 0.0341 0.0101 TNXB Body cg22753462 -0.1977 0.0350 0.0085 0.0253 TOP1P2 Body;5'UTR chr22:25159865-25160212 S_Shore cg12352399 0.5773 -0.0613 0.0217 0.0212 TOP2B Body cg07211044 0.1825 -0.0317 0.0221 0.0036 TOX TSS1500 chr8:60030134-60032356 S_Shore cg12274663 0.5675 -0.0506 0.0423 0.0442 TP53I11 5'UTR;5'UTR chr11:44971048-44972685 N_Shelf cg24722763 0.8646 -0.0328 0.0488 0.0215 TP53TG5 3'UTR;Body cg16935075 -0.7074 0.0593 0.0026 0.0202 TPH1 TSS200 cg14791008 0.6958 -0.0706 0.0444 0.0213 TPH2 TSS1500 cg09044728 0.6246 -0.0862 0.0076 0.0478 TPI1 3'UTR;Body;3'UTR chr12:6982319-6982936 N_Shelf cg12205230 0.3914 -0.0494 0.0032 0.0231 TPM3 TSS1500 cg23259542 -0.4902 0.0556 0.0306 0.0276 TPRG1 TSS1500 cg13947243 -0.4923 0.0355 0.0340 0.0090 TRAF2 5'UTR chr9:139784322-139784693 N_Shore cg19711268 1.2564 -0.1050 0.0057 0.0189 TRAF3 Body;Body;Body cg06813419 -0.5933 0.0428 0.0005 0.0149 TRAF5 5'UTR;5'UTR chr1:211500151-211500636 S_Shore cg22155281 0.6122 -0.0339 0.0165 0.0499 TRAM1L1 TSS1500 chr4:118006538-118006859 S_Shore cg08498647 -0.3351 0.0520 0.0114 0.0295 TREH TSS1500 cg01765174 -0.6900 0.0322 0.0091 0.0219 TRIM14 Body;Body;Body;Body chr9:100881098-100881660 N_Shore cg01083029 0.6119 -0.0362 0.0002 0.0020 TRIM26 5'UTR cg02007150 0.8497 -0.0496 0.0094 0.0085 TRIM39 TSS1500;Body;Body;TSS1500 chr6:30294169-30295071 N_Shore cg12819144 0.6765 -0.0630 0.0086 0.0178 TRIM60 TSS200 cg14776998 0.3999 -0.0413 0.0047 0.0306 TRIM71 Body chr3:32863174-32863415 S_Shore cg22241777 0.8739 -0.0556 0.0040 0.0077 TRIP12 5'UTR chr2:230785912-230787665 N_Shelf cg03135127 0.5440 -0.0416 0.0392 0.0387 TRMT1 1stExon;5'UTR;5'UTR;5'UTR;1stExon chr19:13226897-13227660 Island cg01907194 -0.6454 0.0779 0.0034 0.0458 TRMT61A 3'UTR chr14:104000887-104001138 S_Shelf cg10969919 0.6065 -0.0545 0.0255 0.0258 TRPC7 Body;Body;Body chr5:135692397-135693042 S_Shore cg23693752 -0.3408 0.0484 0.0146 0.0009 TRPM1 5'UTR cg21120661 -0.4645 0.0456 0.0013 0.0103 TRPM2 Body chr21:45811345-45811550 N_Shore

cg11475555 0.2154 -0.0388 0.0260 0.0328 TRPV3 TSS200 cg03806175 0.3701 -0.0398 0.0440 0.0218 TRRAP Body chr7:98579439-98579640 N_Shore cg07730183 -0.4350 0.0397 0.0055 0.0001 TSC2 Body;Body;Body chr16:2134259-2134632 S_Shore cg22721472 -0.3506 0.0400 0.0006 0.0127 TSHZ3 3'UTR cg04022379 0.6572 -0.0308 0.0268 0.0113 TSLP Body;TSS1500 chr5:110408704-110409039 Island cg06541938 -0.6502 0.0719 0.0077 0.0048 TSNARE1 5'UTR cg10317111 -0.6333 0.0897 0.0063 0.0056 TSPAN3 Body;Body;Body cg20171011 0.7814 -0.0562 0.0427 0.0338 TSPAN4 Body;Body;Body;Body;Body;Body;Body cg06847157 0.5517 -0.0594 0.0018 0.0211 TSSC4 TSS200 chr11:2421040-2422474 S_Shore cg24901317 -0.4383 0.0472 0.0171 0.0320 TTBK1 Body chr6:43230610-43231064 N_Shelf cg00018229 0.1924 -0.0356 0.0225 0.0178 TTC13 Body;TSS1500;Body chr1:231113871-231114873 N_Shore cg24550149 0.5179 -0.0393 0.0461 0.0093 TTC22 Body chr1:55246742-55247519 Island cg15528722 0.6861 -0.0772 0.0380 0.0385 TTC33 TSS1500 chr5:40755537-40756257 S_Shore cg12639429 -0.2308 0.0344 0.0338 0.0437 TTC39C TSS200 cg24036116 0.6528 -0.0855 0.0126 0.0145 TTC7B Body chr14:91282227-91282757 N_Shore cg11984463 0.4262 -0.0695 0.0014 0.0136 TTC9B TSS1500 chr19:40723104-40724389 S_Shore cg17510786 -0.4256 0.0340 0.0094 0.0318 TTLL10 Body;Body chr1:1115574-1116006 Island cg14084730 0.9768 -0.0577 0.0129 0.0055 TXLNA 5'UTR chr1:32645154-32645814 Island cg04563169 0.3060 -0.0501 0.0254 0.0166 TXNRD1 Body chr12:104659057-104659583 S_Shore cg01918043 0.6251 -0.0545 0.0126 0.0095 UACA Body chr15:71054898-71056230 N_Shore 1stExon;5'UTR;1stExon;5'UTR;Body;Body;B cg02405476 0.5454 -0.0326 0.0052 0.0492 UBE2C ody;Body chr20:44440946-44441655 S_Shore cg17204510 0.3156 -0.0320 0.0088 0.0287 UBE2D2 5'UTR;Body cg15251697 0.3465 -0.0346 0.0115 0.0306 UBE2G1 Body chr17:4268625-4270155 N_Shelf cg04523320 -0.6544 0.0539 0.0252 0.0209 UBE2K Body;Body;Body chr4:39772810-39773309 N_Shore ch.17.1996417R -0.5496 0.0655 0.0309 0.0433 UBE2O Body cg13411658 0.6105 -0.0407 0.0006 0.0017 UBR3 Body cg23947545 -0.4481 0.0385 0.0290 0.0359 UBTD2 3'UTR cg12039314 0.6927 -0.0378 0.0090 0.0103 UBXN2B Body cg18067103 0.7240 -0.0338 0.0303 0.0264 UCHL3 Body chr13:76123438-76124268 S_Shelf cg10171609 -0.4860 0.0398 0.0087 0.0341 UCN3 TSS1500 cg19750657 0.8125 -0.0396 0.0315 0.0419 UFM1 3'UTR cg18313132 0.4479 -0.0301 0.0157 0.0221 UGT1A8 TSS1500

cg17136038 -0.3357 0.0502 0.0020 0.0026 UHRF1BP1 Body chr6:34759534-34760309 S_Shelf cg01763051 -0.5155 0.0490 0.0166 0.0383 ULBP1 Body chr6:150284682-150286515 Island cg11881146 1.0699 -0.1089 0.0154 0.0114 UNC119 TSS1500;TSS1500;3'UTR chr17:26879239-26879787 S_Shore cg16413715 -0.5999 0.0937 0.0353 0.0396 UNC5A Body chr5:176296541-176296933 Island cg05673137 -0.2506 0.0342 0.0073 0.0359 UNC5CL TSS200 cg11736091 0.7587 -0.0359 0.0340 0.0059 UNC84A Body;Body chr7:886803-887535 N_Shelf cg22859847 0.8903 -0.0386 0.0194 0.0100 USP16 TSS200;TSS200;TSS200 chr21:30396848-30397410 N_Shore cg13604623 1.3987 -0.0591 0.0037 0.0307 USP28 Body chr11:113745816-113746693 N_Shore cg26561986 -0.5277 0.0469 0.0003 0.0040 USP44 5'UTR;5'UTR chr12:95941906-95942979 N_Shelf cg17274681 1.0113 -0.0455 0.0130 0.0114 UST TSS1500 chr6:149068179-149069775 N_Shore cg18442587 0.7491 -0.0349 0.0291 0.0134 VASH1 1stExon;5'UTR chr14:77227569-77228691 S_Shore cg17853850 0.9380 -0.0818 0.0024 0.0157 VASH2 TSS1500;TSS1500;TSS1500 chr1:213123647-213125092 N_Shore cg14415079 -0.6477 0.0790 0.0061 0.0143 VAV2 Body;Body chr9:136659111-136659329 N_Shelf cg05510041 0.6796 -0.0325 0.0034 0.0477 VCL Body;Body chr10:75757484-75758227 S_Shore cg19743759 2.3765 -0.1634 0.0021 0.0186 VCP TSS200 chr9:35071756-35072885 Island Body;Body;Body;Body;Body;Body;Body;Bod y;Body;Body;Body;Body;Body;Body;Body;B cg02397182 1.2938 -0.0972 0.0245 0.0478 VEGFA ody chr6:43737632-43739852 Island cg14664726 -0.6156 0.0871 0.0265 0.0062 VGLL2 3'UTR;3'UTR chr6:117591533-117592279 S_Shelf cg08693281 0.7416 -0.0582 0.0159 0.0110 VIPR2 Body chr7:158856817-158857209 Island cg15599795 -0.3872 0.0437 0.0033 0.0142 VOPP1 Body cg24003216 -0.7844 0.0781 0.0233 0.0130 VPS13B Body;Body cg04275506 0.7130 -0.0357 0.0439 0.0297 VPS13D Body;Body cg14715030 1.0539 -0.1181 0.0100 0.0053 VPS53 Body;Body cg12704672 0.6849 -0.0375 0.0416 0.0374 VSIG8 TSS1500 cg07856295 -0.7905 0.0350 0.0087 0.0396 VSNL1 Body cg10743390 0.3335 -0.0365 0.0134 0.0214 VSTM2B Body chr19:30015781-30021367 Island cg12532653 0.3865 -0.0401 0.0350 0.0185 VTRNA1-1 TSS1500 cg00299558 0.4744 -0.0811 0.0292 0.0391 VWA5B2 Body;TSS1500 chr3:183959061-183959747 N_Shore cg09847027 -0.3483 0.0302 0.0428 0.0481 WAC Body;Body;Body cg23151401 0.3246 -0.0409 0.0449 0.0001 WBSCR26 TSS1500 chr7:73152564-73153716 N_Shelf cg18086582 -0.5024 0.0346 0.0157 0.0030 WDR13 Body;Body;Body chrX:48455942-48456594 S_Shelf cg24378470 1.0129 -0.0627 0.0126 0.0447 WDR16 TSS1500;Body;TSS1500 chr17:9479007-9479225 N_Shore cg15313936 0.7569 -0.0872 0.0154 0.0199 WDR20 Body;Body;Body;Body chr14:102605597-102606977 S_Shore

cg23612492 -0.3565 0.0326 0.0029 0.0088 WDR25 Body;Body cg13082120 0.7523 -0.0338 0.0323 0.0454 WDR46 1stExon;5'UTR;1stExon;TSS1500;5'UTR chr6:33256539-33256973 S_Shore cg16649298 -0.7266 0.0343 0.0006 0.0186 WDR60 Body cg06857900 -0.7301 0.0411 0.0345 0.0002 WDR66 Body cg20667778 0.7366 -0.0543 0.0205 0.0431 WDR72 Body cg16659003 0.9833 -0.0326 0.0325 0.0143 WDSUB1 5'UTR;5'UTR;5'UTR chr2:160142607-160143567 Island cg17806224 -0.2632 0.0468 0.0315 0.0009 WIPF3 Body chr7:29923882-29924264 S_Shelf cg17218062 0.3567 -0.0340 0.0117 0.0179 WISP1 Body;Body cg24286165 0.6696 -0.0455 0.0069 0.0304 WIT1 Body chr11:32459422-32459878 N_Shore cg20702935 0.7796 -0.0458 0.0123 0.0426 WIZ 5'UTR;TSS200 chr19:15563869-15564223 N_Shelf cg05600023 0.8456 -0.1201 0.0067 0.0260 WNT4 Body chr1:22446520-22446943 S_Shore cg09774932 0.5301 -0.0427 0.0116 0.0165 WNT5B TSS1500 cg10711871 -0.1976 0.0369 0.0125 0.0244 WNT7A Body chr3:13860434-13860882 Island cg10818702 0.4256 -0.0319 0.0486 0.0304 WRB 3'UTR;3'UTR cg02789515 -0.4243 0.0606 0.0077 0.0171 WSB1 TSS1500;TSS1500 chr17:25620999-25621730 N_Shore cg12521910 0.4262 -0.0486 0.0002 0.0092 XAGE3 TSS1500;TSS1500 cg00848245 -0.4893 0.0676 0.0145 0.0323 XPO6 TSS1500 chr16:28223083-28223638 S_Shore cg22026687 1.1114 -0.0339 0.0144 0.0414 XPR1 TSS1500;TSS1500 chr1:180601027-180601816 N_Shore cg22891520 0.1889 -0.0339 0.0355 0.0435 YME1L1 TSS1500;TSS200;TSS1500 chr10:27444133-27444494 N_Shore cg26462319 0.5144 -0.0308 0.0277 0.0028 YPEL5 Body;Body;Body;Body cg03219514 -0.6830 0.0424 0.0038 0.0297 ZAP70 Body;TSS200 chr2:98350984-98351257 N_Shore cg03537740 -0.3901 0.0466 0.0373 0.0078 ZBTB12 Body chr6:31868781-31870311 N_Shore cg14258935 -0.2501 0.0352 0.0287 0.0210 ZBTB22 Body;TSS1500;TSS1500;TSS1500;Body chr6:33281112-33281827 S_Shore cg01395650 -0.5298 0.0301 0.0049 0.0460 ZBTB41 TSS1500 chr1:197170005-197170719 Island cg14351767 1.2098 -0.0311 0.0134 0.0459 ZBTB5 Body cg04644653 -0.7359 0.0316 0.0475 0.0074 ZBTB7C Body chr18:45555644-45556213 Island cg03140118 0.6265 -0.0598 0.0080 0.0038 ZC3H12A TSS1500 chr1:37939723-37940650 N_Shore cg27115978 -0.2020 0.0304 0.0071 0.0075 ZC3H18 5'UTR cg04878745 1.5072 -0.0748 0.0406 0.0375 ZC3H3 Body cg24181914 0.5689 -0.0544 0.0228 0.0441 ZC3H4 TSS1500 chr19:47615253-47617101 S_Shore cg00535466 -0.8260 0.0924 0.0235 0.0222 ZC3H8 TSS1500 chr2:113012108-113012784 S_Shore cg27326620 -0.7637 0.0412 0.0076 0.0241 ZC4H2 TSS1500 cg00868074 -0.2446 0.0455 0.0014 0.0260 ZCCHC14 3'UTR chr16:87441387-87441671 Island

cg13863769 0.6608 -0.0420 0.0116 0.0464 ZCCHC2 3'UTR cg03820837 0.8135 -0.0454 0.0008 0.0204 ZCWPW2 TSS1500 cg10307602 -0.3989 0.0336 0.0013 0.0089 ZDHHC14 Body;Body cg23869439 0.9388 -0.0407 0.0015 0.0176 ZDHHC2 Body cg10363915 0.4554 -0.0354 0.0252 0.0305 ZDHHC5 5'UTR chr11:57434542-57434788 S_Shelf cg05543909 0.5825 -0.0437 0.0254 0.0015 ZFHX3 3'UTR;3'UTR chr16:72821140-72821592 N_Shore cg06169590 0.7378 -0.0308 0.0447 0.0194 ZFP36L2 TSS1500;Body chr2:43451445-43454951 S_Shore cg20232550 -0.3508 0.0455 0.0315 0.0059 ZFP41 3'UTR cg01062937 -0.1232 0.0309 0.0206 0.0303 ZFPM1 Body chr16:88536936-88537375 Island cg10898258 0.3863 -0.0550 0.0195 0.0185 ZFYVE21 Body chr14:104193901-104194627 N_Shore cg15002294 0.5051 -0.0507 0.0064 0.0300 ZIC1 TSS1500 chr3:147126988-147128999 N_Shore cg04765410 0.4496 -0.0304 0.0153 0.0088 ZMIZ1 Body cg27263483 0.6994 -0.0376 0.0419 0.0242 ZNF134 3'UTR cg21880712 0.5775 -0.0411 0.0174 0.0268 ZNF136 3'UTR cg10227731 -1.0411 0.0306 0.0149 0.0221 ZNF16 5'UTR;5'UTR chr8:146175835-146176337 Island cg15264273 0.5101 -0.0313 0.0183 0.0200 ZNF169 5'UTR cg02595681 1.0568 -0.0605 0.0130 0.0098 ZNF215 TSS1500 chr11:6947520-6948212 N_Shore cg19739578 0.5951 -0.0522 0.0407 0.0145 ZNF219 TSS1500 chr14:21571835-21572520 S_Shore cg27273602 0.4604 -0.0325 0.0123 0.0194 ZNF23 5'UTR chr16:71495773-71496260 N_Shelf cg03639749 -0.2730 0.0362 0.0237 0.0190 ZNF26 TSS1500 chr12:133562710-133563453 N_Shore cg12096988 -0.9478 0.0340 0.0192 0.0005 ZNF264 TSS200 chr19:57702696-57703425 Island cg10982935 0.9931 -0.1712 0.0009 0.0010 ZNF280C TSS1500 chrX:129402458-129403088 Island cg17173891 1.0265 -0.0725 0.0001 0.0056 ZNF292 Body cg10210624 0.6370 -0.0842 0.0021 0.0093 ZNF329 TSS1500 chr19:58661737-58662287 S_Shore cg14884747 0.6392 -0.0343 0.0174 0.0235 ZNF330 TSS1500 chr4:142141971-142142359 N_Shore cg05136804 -0.4239 0.0318 0.0019 0.0142 ZNF397OS 5'UTR;5'UTR chr18:32847284-32848130 S_Shore cg00175987 0.6698 -0.0312 0.0266 0.0332 ZNF407 TSS1500;TSS1500;TSS1500 cg02705894 -0.5119 0.0362 0.0163 0.0386 ZNF420 3'UTR cg26442883 -0.3830 0.0521 0.0087 0.0185 ZNF423 Body cg13660163 0.9131 -0.0818 0.0205 0.0198 ZNF491 TSS200 chr19:11909402-11909841 N_Shore cg18611281 0.7749 -0.0398 0.0158 0.0055 ZNF512 TSS200 chr2:27805754-27806078 Island cg11611011 -0.6120 0.0351 0.0089 0.0467 ZNF524 Body chr19:56113827-56114232 Island cg20103843 0.5260 -0.0313 0.0035 0.0310 ZNF560 Body

cg07378091 0.5646 -0.0343 0.0495 0.0288 ZNF564 1stExon;5'UTR chr19:12661804-12662302 Island cg18457438 -0.5703 0.0364 0.0090 0.0192 ZNF575 Body chr19:44039232-44039756 Island cg08729059 0.4636 -0.0787 0.0025 0.0150 ZNF593 TSS1500 chr1:26496179-26496824 N_Shore cg23699046 -0.3052 0.0311 0.0313 0.0455 ZNF605 TSS1500;TSS1500 chr12:133532642-133532979 S_Shore cg17407324 -0.6880 0.0558 0.0111 0.0061 ZNF615 Body TSS1500;TSS1500;TSS1500;TSS1500;TSS150 cg12176605 0.3209 -0.0351 0.0324 0.0125 ZNF619 0;TSS1500 chr3:40518517-40518848 N_Shore cg07000116 -0.5902 0.0388 0.0318 0.0300 ZNF689 Body chr16:30615777-30616286 S_Shore cg25397663 0.6143 -0.0593 0.0142 0.0258 ZNF718 Body chr4:124332-124841 Island cg20431080 0.8586 -0.0514 0.0071 0.0157 ZNF777 TSS200 chr7:149156561-149158080 S_Shore cg23816537 -0.4799 0.0477 0.0289 0.0056 ZP1 TSS200 cg19988566 1.3722 -0.0780 0.0065 0.0384 ZRANB1 3'UTR cg07369950 1.0442 -0.0546 0.0368 0.0292 ZSCAN18 TSS1500;Body;TSS1500;TSS1500 chr19:58609338-58609988 Island cg24441954 -0.8682 0.0613 0.0268 0.0081 ZSCAN23 3'UTR cg06395265 0.5167 -0.0381 0.0227 0.0023 ZSWIM1 Body cg11023075 -0.6980 0.0491 0.0214 0.0333 ZSWIM6 Body chr5:60626505-60629809 S_Shelf cg14497327 -0.5622 0.0303 0.0024 0.0144 ZYX TSS200;TSS200 chr7:143077469-143079169 Island cg12087627 -0.4147 0.0571 0.0435 0.0046 ZZEF1 Body chr17:3907378-3907703 S_Shelf

Supplementary Table 4: List of Primer Oligosfor Pyrosequencing

HK1 HDAC5

Forward Primer ATTGAGGTTTAGTTTTTGGTAGGAGTAGGA TTAGGGGTTGGGAGGGTTA

Reverse Primer CCTAACTCATTTCCACCTCAC CCCTAACCTTTCCCAAACTTTTCTT

Sequencing Primer GGTATGTTAGTTTTTAGTAGGT GGTTGGGAGGGTTAT

Biotin On the reverse primer On the reverse primer

Methylation analysis was performed using PyroMark Q24 (Qiagen). Primers for specific regions were from Qiagen (DAPK3: PM00614166; ATP2A3: PM00614320) or designed manually as detailed above using PyroMark Assay Design 2.0 software (Qiagen). After bisulfite conversion, DNA was amplified by PCR using the PyroMark PCR kit (Qiagen). Annealing temperature was optimized for each primer set. Non-CpGcytosines were used as an internal control for the bisulfite conversion efficiency. Completely methylated, unmethylated, and a mixture of both control DNA also used to determine the detection limits of the assay. Data are reported as percentage methylation by determining the number of times the site was detected as cytosine in the context of the total number of times the site was detected as thymine or cytosine. Data were analyzed using PyroMark Q24software (Qiagen).

Supplementary Table 5: Methylation Landscape for Genes Identified up to 200kb from DAPK3 3’UTR.

Gene Target Gene (%) DNA Fold change p

(# of probes*) ID region Methylation Insulin/Basal

EEF2(34) cg16142977 TSS1500 0 0.81 0.01

EEF2(34) cg07663404 Body 1 1.01 0.03

EEF2; SNORD37(13) cg20738733† Body; TSS1500 -2 0.97 0.01

EEF2; SNORD37(13) cg05948856† Body; TSS1500 -5 0.94 0.03

ZFR2(60) cg13983692 Body 4 1.07 0.02

ATCAY(21) All probes - - - > 0.05

MATK(25) All probes - - - > 0.05

DNA methylation differences are reported as percent change and fold change between the basal sand insulin-stimulated skeletal muscle.*Number of probes on the array that can be related to each gene identified within 200 kb of DAPK3 3’UTR.A total of 153 probes were identified on the array within 200 kb of DAPK3 3’UTR. †Ambiguous probe which could also reflect changes close to SNORD37, which is located on a different chromosome from DAPK3.5 probes had significant p-values:Paired Student’s t- tests were performed on β values. Using M values, no CpG in this region were significantly altered by insulin treatment. Furthermore, since we used β valuesin Table 3 for ATP2A3 and DAPK3, we have evaluated them here as well to be consistent.