CREB phosphorylation

Ribosomal S6 kinase_UNCURATED Ribosomal protein S6 alpha 3 NOTCH1 Intracellular Domain Regulates Transcription Interleukin-4 and 13 signaling Senescence-AssociatedRecycling pathway Secretory of L1 Phenotype (SASP) Hypoxia-inducible factor 1 alpha RSK activation Regulation of expression by Hypoxia-inducible Factor Circadian Clock Neddylation CREB phosphorylation through the activation of Ras Gastrin-CREB signalling pathway via PKC and MAPK Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ERK/MAPK targets Oxygen-dependentHypoxia inducible asparagine factors; hydroxylationHIF-1-alpha, HIF-2-alpha of Hypoxia-inducible Factor Alpha PTK6 Expression Negative feedback regulation of MAPK pathway BMAL1:CLOCK,NPAS2 activates circadian gene expression Thrombin signallingRHO through GTPasesSignaling proteinase Activate by moderate activated WASPs kinase receptorsand WAVEsactivity (PARs) BRAF mutants PTK6 promotes HIF1A stabilization FCERI mediated MAPK activation MAP2K and MAPK activation Growth hormone receptor signaling Ub-specific processing proteases ERKs are inactivated MAP kinaseRegulation ERK2 of actin dynamics for phagocytic cup formation Mitogen-activatedNegative protein regulation kinase; ERK1/ERK2 of FGFR4 signaling RAF-independent MAPK1/3 activation Neutrophil degranulation MAPK1 (ERK2) activation Signal transduction by L1Negative regulation of FGFR2 signaling HSP90 chaperone cycle for steroid hormone receptors (SHR) HSP40, subfamily A, putative Signaling by high-kinaseSignal activity attenuation BRAF mutants phospho-PLA2 pathwayNegativeRegulation regulation ofRAF/MAP ofPTEN FGFR3 gene kinasesignaling transcription cascade Negative regulationSignaling of FGFR1 by BRAF signaling and RAF fusions Uptake and function of anthrax toxins PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of NegativeHSF1-mediated regulation heat of shockMAPK response pathway Advanced glycosylationActivation endproduct ofNCAM the AP-1 signaling receptor family offor signaling transcription neurite out-growth factors Anthrax lethalAntrax factor lethal toxin Oncogene Induced Senescence TGF-beta receptor signaling activates SMADs Signaling by RAS mutants SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Spry regulation of FGF signaling Paradoxical activationOxidative of RAF Stress signaling Induced by kinase Senescence inactive BRAF Mothers against decapentaplegic homolog 3 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 regulates CDKN1A transcription TGFBR1 KD Mutants in Cancer Signaling by Activin DownregulationSMAD2/3 Phosphorylation of TGF-beta receptor Motif Mutants signaling in Cancer SMAD4 MH2 Domain Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity Glycoprotein hormones Signaling by NODAL SMAD2/3 MH2 Domain Mutants in Cancer Reactions Thyroxinespecific to biosynthesisthe complex N-glycan synthesis pathway TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Golgi Cisternae Pericentriolar Stack Reorganization Glycoprotein hormones alpha chain Hedgehog 'on' state Mineralocorticoid biosynthesis Intraflagellar transport Androgen biosynthesis Tubulin beta chain Tubulin

Hedgehog 'off' state ParathyroidClass B/2 hormone (Secretin receptor family receptors) G alpha (s) signalling events

Glucagon-like peptide 1 receptor

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-type ligand receptors PKA activation in glucagon signalling CDT1 association with the CDC6:ORC:originProstacyclin complex signalling through prostacyclin receptor Vasopressin regulates renal water homeostasis via Aquaporins Association of licensingGeminin factors with the pre-replicative complex Guanine nucleotide-bindingGlucagon signaling protein in G(s), metabolic subunit regulation alpha Removal of licensing factors from origins

Miscellaneous substrates

Fatty acids Cytochrome P450 2D6

Cytochrome P450 1A2 Cytochrome P450 1A Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

G alpha (z) signalling events

Ca2+ pathway SyndecanRegulation interactions of KIT signalingSignaling by SCF-KIT Trafficking of GluR2-containing AMPA receptors WNT5A-dependent internalization of FZD4 RET signalingPKC alpha and beta-2 C alpha SHC1 events in ERBB2 signaling HuR (ELAVL1) binds and stabilizes mRNA Inactivation, recovery and regulationProtein of the phototransduction kinase C, PKC; classical/novel cascade Disinhibition of SNAREEGFR formation Transactivation by Gastrin Acetylcholine regulatesProtein insulin kinase secretion C (PKC) Depolymerisation of the Nuclear Lamina CalmodulinResponse induced to elevated events platelet cytosolic Ca2+ VEGFR2 mediated cell proliferation