N-Glycan Trimming in the ER and Calnexin/Calreticulin Cycle
Total Page:16
File Type:pdf, Size:1020Kb
Neurotransmitter receptorsGABA and A postsynapticreceptor activation signal transmission Ligand-gated ion channel transport GABAGABA Areceptor receptor alpha-5 alpha-1/beta-1/gamma-2 subunit GABA A receptor alpha-2/beta-2/gamma-2GABA receptor alpha-4 subunit GABAGABA receptor A receptor beta-3 subunitalpha-6/beta-2/gamma-2 GABA-AGABA receptor; A receptor alpha-1/beta-2/gamma-2GABA receptoralpha-3/beta-2/gamma-2 alpha-3 subunit GABA-A GABAreceptor; receptor benzodiazepine alpha-6 subunit site GABA-AGABA-A receptor; receptor; GABA-A anion site channel (alpha1/beta2 interface) GABA-A receptor;GABA alpha-6/beta-3/gamma-2 receptor beta-2 subunit GABAGABA receptorGABA-A receptor alpha-2receptor; alpha-1 subunit agonist subunit GABA site Serotonin 3a (5-HT3a) receptor GABA receptorGABA-C rho-1 subunitreceptor GlycineSerotonin receptor subunit3 (5-HT3) alpha-1 receptor GABA receptor rho-2 subunit GlycineGlycine receptor receptor subunit subunit alpha-2 alpha-3 Ca2+ activated K+ channels Metabolism of ingested SeMet, Sec, MeSec into H2Se SmallIntermediateSmall conductance conductance conductance calcium-activated calcium-activated calcium-activated potassium potassium potassiumchannel channel protein channel protein 2 protein 1 4 Small conductance calcium-activatedCalcium-activated potassium potassium channel alpha/beta channel 1 protein 3 Calcium-activated potassiumHistamine channel subunit alpha-1 N-methyltransferase Neuraminidase Pyrimidine biosynthesis Nicotinamide N-methyltransferase Adenosylhomocysteinase PolymerasePolymeraseHistidine basic proteincatabolism acidic 2 protein Influenza Life Cycle FusionHemagglutinin of the Influenza Virion to the Host Cell Endosome Dihydroorotate dehydrogenase UncoatingBudding of the InfluenzaPA/PB1 Virion Uridine Dihydroorotase5'-monophosphate synthase Packaging of EightRelease RNA Segments Entry of Influenza Virion into Host Cell via Endocytosis Viral mRNA Translation Assembly of Viral Components at the Budding Site Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus Purine salvage Sialic acid metabolism Transport of organic anions Serotonin (5-HT) receptor D-3-phosphoglycerateSerine biosynthesis dehydrogenase G alpha (s) signalling events Glycosphingolipid metabolism Glucagon-type ligand receptors Potassium transport channels AMP deaminase 1 Deoxycytidine kinase AdenosineAMP deaminase deaminase 2 Metabolism of folate and pterines Hypoxanthine-guanineSialidase 3 phosphoribosyltransferaseAdenosine kinase Pyrimidine salvage ATP-sensitive inward rectifier potassium channel 10 Trace amine-associated receptor 1 Sialidase 2 Adenosine deaminase-like protein ATP-sensitive inward rectifier potassium channel 1 CMP-N-acetylneuraminate-beta-1-4-galactoside alpha-2-3-sialyltransferase Iron CMP-N-acetylneuraminate-beta-galactosamide-alpha-2-3-sialyltransferaseuptakeBeta-galactoside and transport alpha-2-6-sialyltransferase 1 1 Solute carrier organic anion transporter family member N-acylneuraminate-9-phosphatase1C1 Sialidase 4 Solute carrierSolute organic carrier anionorganic transporter anion transporter family family member member 4A11A2 Amine ligand-binding receptors SoluteSolute carrier carrier organic organic anion anion transporter transporter family family member member 2A1 1B1 vRNP Assembly Vasoactive intestinal polypeptide receptor 2 SoluteSolute carrier carrier organic organic anion anion transporter transporter family family member member 1B3 2B1 Vasoactive intestinal polypeptide receptor 1 Urea cycle Formation of the cornified envelopeProton-coupled folate transporter Growth hormone-releasingGastric inhibitoryGastric inhibitory polypeptide polypeptide receptor hormone receptor PituitaryPituitary adenylate adenylate cyclase-activating cyclase-activating polypeptide polypeptidetype I receptor Glucagon-likeSecretin receptor peptide 2 receptor Metabolism of Angiotensinogen to Angiotensins PhosphodiesteraseFollicle stimulatingProstanoid hormone EP4 receptor receptor 3 Kinesins Luteinizing hormone/ChoriogonadotropinAmylin receptorG AMY1- protein-coupled CALCR/RAMP1 receptor kinase 6receptor OrnithineHeme carbamoyltransferase degradation COPI-dependent Golgi-to-ERFolateFolate transporter receptor retrograde 1 beta traffic Adenosine receptors; A2a & A3 AdrenomedullinProstanoid DP receptor PhosphodiesterasereceptorADM2 AM1; CALCRL/RAMP2 7A Arginase-2- mitochondrial PhosphodiesteraseSerotonin 4 (5-HT4) 4D receptor NeutralExtended ceramidase synaptotagmin-1 ThymidineMethylenetetrahydrofolate phosphorylaseSerine hydroxymethyltransferase- dehydrogenase40S cytosolic ribosomal protein SA NGF-independantSurfactant TRKA metabolism activation CalcitoninProstanoidVasopressin IPgene-related receptor V2 receptorADM peptide type 1 receptor CeramideBeta-glucosidase cytosolic kinase Bifunctional methylenetetrahydrofolateUridine-cytidine kinase 2 dehydrogenase/cyclohydrolase-40S ribosomal mitochondrial protein S6 Adenosine A2 receptor CalcitoninPhosphodiesterase receptorRelaxin receptor4A 1 LysosomalNeutral sphingomyelinaseprotectiveSteryl-sulfataseBeta-glucosidase protein Thymidine kinase-Uridine phosphorylase mitochondrial 1 WNT ligand biogenesis and trafficking Adenosine receptors; A1 & A2a Beta-1PhosphodiesterasePhosphodiesterasePhosphodiesterase adrenergicPhosphodiesterase 11A 7B receptor 10A 3B CorticotropinParathyroid releasing hormone factor receptor receptor 1 SialidaseCargo 1 concentration in the ER Adenosine Adenosinereceptor A2a receptorBeta-3Calcitonin-gene-related adrenergicProstanoid EP2 peptide receptorreceptor receptor- CALCRL/RAMP1 Beta-galactosidaseBeta-hexosaminidaseSphingomyelinCeramide glucosyltransferase subunit phosphodiesterase alpha CorticotropinBeta-adrenergicAdrenergic releasingRelaxin receptor receptor factor receptor beta;receptorPhosphodiesterase 2 ADRB1 kinase 2 & ADRB32 2A EctonucleotideCollagen biosynthesis pyrophosphatase/phosphodiesterase and modifying enzymes MHC class family II antigen memberClass presentation 7 B/2 (Secretin family receptors) PhosphodiesteraseHistaminePhosphodiesteraseAmylin 7 receptor H2 AMY3; 1Breceptor CALCR/RAMP3 AdrenomedullinPhosphodiesterasePhosphodiesterase- receptor-PhosphodiesterasePhosphodiesterase AM2; 8A CALCRL/RAMP3PDE1/PDE5 4C 1A ATP-bindingSolute carrier cassette family sub-family 40 member 1G member 2 Adenosine receptors; A2b & A3 DopaminePhosphodiesteraseSerotonin D1 3A receptor 6Dopamine (5-HT6) D5 receptor receptor PhosphodiesteraseSerotoninPhosphodiesterase 7 (5-HT7) 8 receptor 8B Natural resistance-associated macrophage protein 2 COPII (Coat Protein 2) Mediated Vesicle Transport G-protein coupled bile acid receptor 1 AdenosineCalcitonin A2bPhosphodiesterase receptorThyroidPhosphodiesterase;Phosphodiesterase gene-related stimulating 4 hormone peptide 4B PDE3 receptor 1 & PDE4 Activation of Matrix MetalloproteinasesUDP-glucuronosyltransferase 1A4 Guanine nucleotide-binding protein G(s)- subunit alpha UDP-glucuronosyltransferase 1-1 Synthesis of PE Dopamine receptor Brain adenylate cyclase 1 Protein Wnt-2 Adenylate cyclase type II Heme oxygenase 2 Protein-glutamine gamma-glutamyltransferase K G alpha (i) signalling events Guanine nucleotide-bindingAdenylate protein G(i)- alpha-1 cyclase subunit type IX ProstasinKallikrein 14 Synthesis of PC Glucagon receptor KallikreinCaspase-14 8 Clathrin heavy chain 1 Class A/1 (Rhodopsin-like receptors) GuanineGlucagon-like nucleotide-binding peptide 1protein receptor G(k)- alpha-3 subunit Cyclophilin B KallikreinMatriptase 5 Vacuolar protein sorting-associated protein 35 ProlylPurine 4-hydroxylase nucleoside subunit alpha-1 phosphorylase ProbableTubulin protein-cysteine beta-1 chain N-palmitoyltransferase porcupine Degradation of the extracellularCollagen-binding matrix proteinAMPCathepsin 1 deaminase 3 Z Kinesin-likeKinesin-like protein protein 1KIF23 TubulinCholine beta-3 kinaseKinesin-like alpha chain protein KIF2C Protein Wnt-3a MelanocortinMelanocortin receptor receptor 2 1 Angiotensin-convertingAngiotensin-converting enzyme Bone2 enzyme morphogenetic protein 1 40S ribosomal protein S27 Mast cell Carboxypeptidasecarboxypeptidase AB FolateKinesin receptor heavy alphaKinesin-1 chain heavy isoform chain Phosphoethanolamine/phosphocholine 5A Centromere-associated phosphatase protein E MelanocortinMelanocortin receptor (M1 receptor and M4) 5 Adenylate cyclase CathepsinAminopeptidase G A Cathepsin K Glutamate receptor ionotropic- AMPACOPI-mediated 1 Intraflagellaranterograde transport Neurotrophic tyrosine kinase receptor type 2 Solute carrier organic anionRenin transporter familyCathepsin member L2 4C1 Dipeptidyl peptidaseAmphiregulin I Kinesin-like protein KIF3ACholine/ethanolamineTubulin kinase beta-2 chain Alpha-2cMelanocortinMelanocortin adrenergic receptorreceptor receptor 3 4 Adenylate cyclase typeCarboxypeptidase V B2 isoform A Glutamate receptor ionotropic AMPA Proto-oncogene protein Wnt-3 Alpha-2aAdrenergic adrenergic receptor alpha-2 receptor Hedgehog 'off' state Kinesin-like proteinNonsense KIF3B Mediated Decay (NMD)Mitotic enhanced Prometaphase by the Exon Junction Complex (EJC) Regulation of ComplementCoagulation cascade factor X/antithrombin III Cerebroside-sulfataseAcidAlpha-galactosidase ceramidase A N-glycanKinesin-likeKinesin-like trimming protein proteinin the KIFC1 ER KIF1B and Calnexin/CalreticulinTubulin cycle Melatonin receptor 1B GlucagonIntrinsic Pathway of Fibrin Clot Formation Serum albumin Matrix metalloproteinaseArginase-1 10 Corticotropin-releasing factor-binding protein Melatonin2-oxoglutarate receptor 1A receptor 1 Matrix