MINISTRY OF PUBLIC HEALTH OF

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Test items for licensing examination

Krok 1

PHARMACY

(російськомовний варіант)

General Instruction

Every one of these numbered questions or unfinished statements in this chapter corresponds to answers or statements endings. Choose the

answer (finished statements) that fits best and fill in the circle with the corresponding Latin letter on the answer sheet.

Authors of items: Abramov A.V., Akimova Z.I., Antonov Ye.V., Arzumanov P.S., Bilyk O.V., Bolokhovska T.O., Bratenko M.K., Brytska V.S., Buchko O.V., Cherneha H.V., Chernikova E.M., Chesnokova A.O., Diachenko V.Yu., Didenko N.O., Didenko O.V., Dmytriv A.M., Dutka N.M., Fedorovych I.P., Filipets N.D., Filipova L.O., Halkevych I.Y., Halynska V.I., Havryliuk O.V., Herhel T.V., Hlushkova O.M., Hrekova T.A., Hryhorieva N.P., Hrytsiv O.V., Hulai O.I., Hurmak I. S., Kamyshny, Kazmirchuk H.V., Khlus K.M., Klenina O.V., Klepa T.I., Klopotsky H.A., Klymenko A.O., Klymniuk S.I., Kolesnikova T.O., Kolesnyk V.P., Korniyevsky Yu.I., Kosareva A.Ye., Kostiuk L.S., Kovalenko I.M., Kravets D.S., Kremenska L.V., Krisanova N.V., Krushynska T.Yu., Krylova O.V., Kuras L.D., Kurovets L.M., Kuzmenko I.A., Kyshkan I.H., Leochko N.S., Lisnycha A.M., Lukianchuk V.D., Lukovych I.M., Lychko V.H., Lychyk H.Z., Lysenko O.A., Makoid O.B., Maly V.V., Menchuk K.M., Mikhieiev A.O., Moroz A.S., Mykhailova I.V., Mylnikova O.O., Nedostup A.T., Nikitina O.O., Nizhenkovska I.V., Nykyforchyn R.M., Oleshchuk O.M., Osipenko L.K., Podpletnya O.A., Potikha N.Ya., Prysyazhnyuk P.V., Pyda V.P., Reva T.D., Rohovy Yu.Ye., Romanyshyna L.M., Rotar D.V., Rusalov V.L., Rylska T.A., Rymsha O.I., Rysukhina N.V., Savchenko L.H., Savustianenko A.V., Seniutovych N.R., Shanaida M.I., Shatova O.P., Shemchuk L.A., Shemonaieva K.F., Shershun H.H., Shevelova N.Yu., Shevtsov I.I., Shliakhovenko O.O., Shono N.A., Shykula R.H., Siedov V.I., Sira L.M., Skliarov O.Ya., Slobodian K.V., Sokurenko N.D., Soloviova I.V., Stakhmych T.V., Stepanchuk V.V., Stetskiv A.O., Stoletov Yu.V., Stoliarchuk E.V., Streltsova N.Yu., Strilets L.M., Struchaieva H.I., Strumenska O.M., Surova N.A., Tertyshna O.V., Tishchenko I.Yu., Tkachenko V.H., Tkachenko Ye.V., Tomarovska T.O., Trzhetsynsky S.D., Tvorko M.S., Ulizko I.V., Varynsky B.O., Vasiuk S.O., Vasylieva A.H., Velyka A.Ya., Vikhrestiuk S.L., Vynnytska R.B., Yaremiy I.M., Yashchyshyn Z.M., Yushchenko T.I., Yuzyfyshyn M.V., Zahrychuk H.Ya. and Committees of professional expertise.

Item reviewers. Anisimov V.Yu., Cherpak O.M., Deineka S.Ye., Ersteniuk H.M., Filimonova N.I., Herush O.V., Hlushachenko O.O., Holdobina O.V., Hontova T.M., Hryhorieva N.P., Ivanets L.M., Kaluhina S.M., Kaplaushenko A.H., Kobylinska L.I., Kononenko N.M., Korniyevska V.H., Kostina T.A., Kraidashenko O.V., Lisnycha A.M., Liubinets L.A., Makoid O.B., Minarchenko V.M., Mykhalkiv M.M., Oliynyk N.M., Shanaida M.I., Shemchuk L.A., Shtryhol S.Yu., Tomarovska T.O., Vasiuk S.O., Yushchenko T.I., Zahaiko A.L., Zahrychuk H.Ya.

The book includes test items for use at licensing integrated examination “Krok 1. Pharmacy” and further use in teaching.

The book has been developed for students of pharmaceutical faculties and academic staff of higher medical educational establishments.

Approved by Ministry of Public Health of Ukraine as examination and teaching publication based on expert conclusions (Orders of MPH of Ukraine of 14.08.1998 №251, of 27.12.1999 №303, of 16.10.2002 №374, of 29.05.2003 №233).

© Copyright Testing Board.

Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 1

1. What titrimetric method of analysis allopurinol - a competitive inhibitor of requires the use of both external and xanthine oxidase. Xanthine oxidase is a internal indicators? terminal enzyme of catabolism of: A. Nitritometry A. Purine nucleotides B. Alkalimetry B. Glycoproteins C. Complexometric titration C. Phospholipids D. Permanganatometry D. Higher fatty acids E. Argentometry E. Heteropolysaccharides 2. By means of photoelectrocolorimetric 8. Many drugs must be manufactured under analysis the concentration of the followi- strictly aseptic conditions. One such possi- ng can be determined: ble source of microbiological contaminati- on of drugs is laboratory glassware. What A. Colored solution method should be used to sterilize the B. Turbid solution glassware? C. Optically active substance D. Colorless solution A. Dry heat E. Any type of solution B. Ignition C. Boiling 3. A patient suffers from Down’s di- D. Tyndallization sease that manifests as mental retardation, E. Pasteurization shortness of stature, pathologically short fi- ngers and toes, and eyes with mongoloid 9. To determine qualitative content of a slant. Karyotype analysis revealed tri- drug, the drug sample was processed wi- somy 21. What group of diseases does this th 2M solution of HCl. White precipitate pathology belong to? soluble in aqueous ammonia solution was formed. This analytical effect indicates the A. Chromosomal disorders presence of the following cations: B. Molecular genetic disease C. Gametopathy A. Silver(I) D. Fetopathy B. Lead(II) E. Blastopathy C. Mercury(I) 4. Knowing the temperature of phase D. Mercury(II) transformation under a certain pressure is E. Tin(II) extremely important in the process of drugs 10. Name the process of spontaneous manufacturing. This temperature can be adhesion of drops in an emulsion to each calculated using the: other: A. Clausius-Clapeyron equation A. Coalescence B. Trouton’s rule B. Flocculation C. Gibbs’ phase rule C. Sedimentation D. Mendeleev-Clapeyron equation D. Flotation E. Konovalov’s laws E. Coagulation 5. At the triple point on the water phase di- 11. Inheritable genetic disorders can result agram, water is: in disturbed enzyme synthesis in the human A. An invariant system body. What enzyme deficiency results in di- B. A monovariant system sturbed break-up of lactose: C. A bivariant system A. Lactase D. A trivariant system B. Maltase E. A quadrivariant system C. Invertase 6. of a powder depends on D. Lipase the degree of comminution of the substance. E. Peptidase The following value must be measured: 12. To treat the patients with purulent A. Dispersion wounds, a dressing with a certain immobili- B. Concentration zed enzyme is used. Name this enzyme: C. Particle volume D. Particle mass E. Solution density 7. A patient with gout was prescribed Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 2

A. Tripsin be the most advisable in cases of the followi- B. Arginase ng type of infections: C. Catalase D. Alkaline phosphatase A. Viral E. Acid phosphatase B. Helminthic C. Protozoal 13. Cerebrospinal fluid of a patient di- D. Microbioses agnosed with meningitis was taken for E. Fungal analysis. To detect the causative agent the sample was inoculated in a nutrient medi- 19. A chemotherapeutic agent has um. Prior to that a serum had been added bactericidal effect against streptococci, to the medium. What causative agent is staphylococci, bacilli, and clostridia. expected to be obtained in this case? According to its action spectrum this drug belongs to the following group: A. Meningococcus B. Mycobacteria A. Broad spectrum antibacterial agents C. Staphylococcus B. Narrow spectrum antibacterial agents D. Viruses C. Broad spectrum antifungal agents E. Rickettsia D. Antiviral agents E. Antituberculous agents 14. Hormones regulate numerous metabolic processes. What hormone activates 20. It is known that in plants the synthesis glycogen synthesis? of secondary reserve starch occurs in: A. Insulin A. Amyloplasts B. Adrenaline B. Chloroplasts C. Vasopressin C. Chromoplasts D. Thyroxine D. Elaioplasts E. Oxytocin E. Proteinoplasts 15. A structural analog of vitamin PP (ni- 21. A patient has developed anuria. Blood cotinic acid) is used as an antituberculous pressure is 50/20 mm Hg. What process of medicine. Name this medicine: uropoiesis was disturbed resulting in acute decrease of urine output? A. Isoniazid B. Streptocide A. Glomerular filtration C. Riboflavin B. Obligate reabsorption D. Tetracycline C. Facultative reabsorption E. Aspirin D. Tubular secretion E. - 16. A food plant of Polygonaceae family is being studied. The plant has reddish stalk, 22. A 12-year-old boy is of short stature, cordate-sagittate leaves, its fruit is a tri- but his mental development corresponds hedral nutlet. Name this plant: with that of his age group. What hormone deficiency is the most likely to cause this A. Fagopyrum esculentum pathology? B. Persicaria bistorta C. Persicaria hydropiper A. Somatotropin D. Polygonum aviculare B. Insulin E. Rumex confertus C. Oxytocin D. Vasopressin 17. Microscopy of subterranean organs of an E. Adrenaline Аsteraceae family plant shows articulated laticifers with anastomoses filled with whi- 23. A 10-year-old child has height of 178 cm te latex. It is characterisic of the following and body mass of 67 kg. These presentations plant: are caused by the functional disturbance of the: A. Taraxacum officinale B. Helianthus annuus A. Pituitary gland C. Artemisia absinthium B. Thyroid gland D. Bidens tripartitа C. Gonads E. Achillea millefolium D. Adrenal glands E. Parathyroid glands 18. The defensive mechanisms against some infectious diseases can be greatly reinforced 24. A certain infection leads to fetus with interferon. Interferon preparations will malformation if a pregnant woman is Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 3 affected. What vaccine should be used for prevention of this infection? A. Transferases B. Isomerases A. Rubella virus vaccine C. Oxidoreductases B. Influenza virus vaccine D. Ligases C. Mumps vaccine E. Hydrolases D. Poliovirus vaccine E. Antirabic vaccine 31. A patient with high risk of hemorrhages is recommended to take vicasol (menadi- 25. Quantitative content of hydrogen one) by his physician. This drug is the peroxide can be determined by means of structural analog of: the following self-indicator method: A. Vitamin K A. Permanganatometry B. Vitamin A B. Bromatometry C. Vitamin B5 C. Iodometry D. Vitamin B12 D. Nitritometry E. Vitamin B6 E. Argentometry 32. Enzymes are widely used as drugs in 26. Coumarins, vitamin K antagonists, pharmacy. What is the main feature that suppress the processes of blood coagulati- separates enzymes from non-biological on. What protein synthesis is blocked by catalysts? coumarins? A. High specificity and selectivity A. Prothrombin B. High universality B. Gamma globulin C. Low universality C. Albumin D. High dispersion D. Transferrin E. High homogeneity E. Ceruloplasmin 33. Any damage to the patient’s vessels 27. HIV-infection occupational risk groups results in persistent hemorrhage. Blood include people of various professions, clotting factor VIII is deficient in the pati- healthcare workers included. Specify the ent’s blood. What disease does this patient mosl likely route of infection transmission suffer from? for healthcare workers: A. Hemophilia A. Parenteral transmission B. Acute vascular purpura B. Fecal-oral transmission C. Thrombocytopenic purpura C. Droplet transmission D. Anemia D. Transmission via airborne dust particles E. Radiation sickness E. Vector-borne transmission 34. Name the structural unit of a colloidal 28. Microbial survival within environment solution of a medicinal substance: is facilitated by spore formation. What mi- croorganisms of those listed below are spore A. Micelle formers: B. Molecule C. Atom A. Clostridia D. Ion B. Bacteroides E. Zwitterion C. Staphylococci D. Peptococci 35. Protein structure includes proteinogenic E. Peptostreptococci amino acids. What is the position of the ami- no group in the structure of these amino aci- 29. Synthesis of a medicinal substance ds? occurs in an isolated system. What is a di- rection criterion of spontaneous processes? A. α-position B. β-position A. Entropy change C. γ-position B. Gibbs energy D. δ-position C. Helmholtz energy E. -position D. Intrinsic energy E. Enthalpy 36. To induce diabetes mellitus in a rabbit, β-cells of pancreatic islets (islets of 30. An enzyme transports structure Langerhans) were selectively damaged with fragments from one substrate into another. alloxan. What method of diabetes induction Name this class of enzymes: was used in this experiment? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 4

general water hardness of potable water: A. Shutdown B. Irritation A. Complexometric titration C. Introduction of enzymes, hormones B. Acidimetry D. Isolated organs C. Precipitation E. Stimulation D. Oxidimetry E. Alkalimetry 37. A sample section of an axial body shows a complex consisting of phellogen and its 43. Name the reaction producing a golden- derivatives - cork and phelloderm. Name yellow precipitate (”golden rain” reaction): this tissue: A. Precipitation of PbI2 A. Periderm B. Precipitation of PbCl2 B. Colenchyma C. Precipitation of AgI C. Sclerenchyma D. Precipitation of HgI2 D. Epiblema E. Precipitation of Hg2I2 E. Epidermis 44. Name the reactions and reagents that 38. The Mohr method is used to determine under certain conditions allow determinati- mass concentration of sodium chloride in on of certain ions in the presence of other an isotonic solution. Titration is carried out ions: with the following indicator: A. Specific A. Potassium chromate B. Selective B. Fluorescein C. Group C. Ammonium iron(III) sulfate D. Characteristic D. Diphenylcarbazone E. General E. Ferroin 45. In Friedel-Crafts alkylation of aromatic 39. A patient presents with persistent hydrocarbons the following substance is tachycardia, exophthalmos, high excitabi- used as the catalyst: lity, increased basal metabolic rate. What disorder can lead to the development of this syndrome? A. Hyperthyroidism B. Hypoparathyroidism C. Hypothyroidism D. Hyperparathyroidism A. Anhydrous AlCl3 E. Adrenal hypofunction B. Pt 40. Racemose clusters of calcium carbonate C. Cr2O3 crystals are detected among the waste D. Alcoholic NaOH solution products of a protoplast. These crystals are: E. PCl5 A. Cystoliths 46. What compound of those listed below is B. Isolated crystals a condensed arene? C. Raphides D. Styloid crystals E. Crystal druses 41. After the pus sample taken from the urethra had been inoculated on ascitic agar, it resulted in growth of round transparent colonies. Microscopy of the colonies shows gram-negative kidney bean-shaped di- plococci. What causative agent is it? A. Gonococcus B. Pneumococcus C. Meningococcus D. Micrococcus E. Streptococcus 42. Laboratories of various specialization use the following method to determine Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 5

A. A.

B. B.

C. C.

D. D.

E.

E.

47. How does increasing temperature affects physical adsorption of substances? 51. What drug is produced as the result of reaction between salicylic acid and acetic A. Decreases anhydride? B. Increases C. Transforms into chemical adsorption D. Decreases in heterogeneous systems E. Increases in homogeneous systems 48. Gelatin expands the most in the followi- ng solvent: A. Aspirin B. Salicylamide A. Water C. Phenyl salicylate B. Acetic acid solution D. Benzyl salicylate C. Ethanol E. Sodium salicylate D. Diethyl E. Benzene 52. Glucose oxidation with a potent oxidi- zing agent (concentrated HNO3)resultsin 49. Azo dyes are produced as the result of: production of: A. Azo coupling B. Diazotization C. Amination D. Nitration E. Nitrosation 50. What reaction results in production of phthalic anhydride? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 6

A. A. Pyrimidine nucleotides synthesis B. Carbohydrate disintegration C. Purine nucleotides synthesis D. Purine nucleotides disintegration E. Lipids synthesis 55. During assessment of air purity in an aseptic unit of a phamacy, sedimentation D-glucaric acid analysis had been applied. Test resulted B. in growth of the small colonies with areas of hemolysis. What medium was used for inoculation? A. Blood agar B. Levine’s formulation (Eosin Methylene Blue agar) C. Endo agar D. Ploskirev’s agar D-gluconic acid E. Egg-yolk salt agar C. 56. According to van’t Hoff rule, when the temperature is raised by 10 degrees, the reaction rate increases by: A. 2-4 times B. 1.5 times C. 5times D. 10 times D-glucuronic acid E. Temperature does not affect reaction rate D. 57. What standard solution can be used to standardize the solution of I2? A. Sodium thiosulfate solution B. Potassium iodide solution C. Potassium dichromate solution D. Potassium permanganate solution D-galactaric (mucic) acid E. Sodium nitrite solution E. 58. Catalysts are widely used in production of drugs. How can reaction acceleration in the presence of a catalyst be explained? A. Activation energy decreases B. Total collision frequency increases C. Activation energy increases D-arabinaric acid D. Collision frequency decreases 53. A patient, who lives in the area E. Molecule speed increases with specific geochemical conditions, 59. On examination the patient’s sclera and was diagnosed with endemic goiter. oral mucosa are icteric. What biochemi- What microelement deficiency results in cal blood value can be expected to be development of this pathology? increased? A. I A. Bilirubin B. Cl B. Amylase C. Br C. Glucose D. F D. Albumin E. Na E. Cholesterol 54. An oncological patient was prescribed 60. Microorganisms in the environment are fluorouracil that is a competitive inhibitor of being affected by various physical factors. thymidine synthase. It inhibits the process What is the effect of high temperature on a of: microbial cell? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 7

A. Irreversible degradation of all cellular A. To distribute between the mobile and structures stationary phases B. Mutagenic effect B. To distribute between two mobile phases C. Transition into anabiosis state C. To distribute between two stationary D. Albuminolysis phases E. Fats saponification D. To dissolve E. To precipitate 61. Extreme therapeutic effect of activated carbon is due to its high specificsurface 67. Quantitative content of oxalic area. Name the phenomenon when gases acid can be determined by means of are absorbed only by the surface of a solid permanganatometry. How to determine body: equivalence point for this kind of titration? A. Adsorption A. When titrate changes its color after B. Adhesion another drop of process solution is added C. Desorption B. With redox indicator diphenylamine D. Cohesion C. With pH indicator E. Recuperation D. With specific indicator E. With adsorption indicator 62. Pastes are used in medicine to treat skin diseases. What type of disperse systems are 68. Surfactants and high-molecular they? compounds are added into concentrated emulsions to stabilize them. These A. Suspensions substances are: B. Emulsions C. Powders A. Emulsifiers D. Foams B. Activators E. Aerosols C. Catalysts D. Solvents 63. In photometric analysis the series of 6-8 E. Absorbents standard solutions is used: 69. Reaction of benzene sulfonation A. To build a calibration curve produces: B. To assess determination method C. To simplify working method D. To choose cuvettes E. To choose optical filter 64. Ammonium iron(III) sulfate can be used as an indicator in: A. Argentometry, Volhard method B. Argentometry, Mohr method C. Alkalimetry D. Acidimetry E. Complexometric titration 65. Quantitative determination of iodine is done by means of: A. Redox titration B. Alkalimetry C. Complexometric titration D. Acidimetry E. Precipitation titration 66. Separation of substances in chromatography is based on the ability of solutes: Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 8

A. trofurazone) the patient developed signi- ficant labial edema. What type of allergic reaction is observed in this case? A. Anaphylactic B. Delayed-type hypersensitivity B. C. Cytolytic D. Stimulated E. Immune complex 72. A patient with gastric carcinoma has undergone several courses of radiation C. therapy. What system is the first to become functionally disturbed after the body was exposed to ionizing radiation? A. Blood B. Nervous C. Digestive D. D. Urinary E. Respiratory 73. A patient with acute myocardial infarcti- on received anticoagulation therapy. What compound will have anticoagulation effect? E. A. Heparin B. Hyaluronic acid C. Chondroitin sulfate D. Dermatan sulfate E. Keratan sulfate

70. Choose the reaction of ester production 74. Specify what method of redox titration among those listed below: requires the use of specific indicator - starch -tofix the end point: A. A. Iodometry B. Permanganatometry C. Nitritometry D. Cerimetry E. Bromatometry B. 75. Causative agents of infectious diseases can be carried both by humans and animals. Name the group of infections that affect ani- mals and can be passed onto humans: C. A. Zooanthroponoses B. Sapronoses C. Anthroponoses D. Zoonoses D. E. Mixed 76. During regular check-up a patient presents with enlarged thyroid gland, exophthalmos, increased body temperature, E. heart rate up to 110/min. What hormone should be measured in the patient’s blood in this case? A. Thyroxin B. Testosterone C. Glucagon 71. A 25-year-old man has an appointment D. Insulin with the dentist. Several minutes after his E. Cortisol oral cavity was lavaged with furacilin (ni- Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 9

77. AfruittreeofRosaceae family has short conclusion additionally, a leaf of this plant thorny shoots; the fruit is a distinctively- was examined under the microscope and a shaped pome with stone cells in its pulp. search for the following crystalline inclusi- Name this plant: ons was conducted: A. Pyrus communis A. Raphides B. Malus sylvestris B. Single crystals C. Cerasus vulgaris C. Druse crystals D. Prunus armeniaca D. Styloid crystals E. Prunus spinosa E. Crystal sand 78. Pharmacopoeia reaction to determine 84. What type of conducting bundle benzoate ions requires interaction with the is characteristic of primary anatomical solution of: structure of a root? A. Iron(III) chloride A. Radial B. Potassium chloride B. Concentric C. Resorcin C. Closed collateral D. Acetic anhydride D. Bicollateral E. Diphenylamine E. Open collateral 79. What solution can be used to detrmine 85. Calendula officinalis as a representative the presence of chloride ions in the potable of Asteraceae family can be characterized water? by the following type of inflorescence: A. Silver nitrate A. Anthodium B. Iodine B. Umbel C. Potassium bromate C. Catkin D. Sodium hydroxide D. Capitulum E. Ammonia E. Corymb 80. Insulin production in β-cells involves 86. In the age of 5 months the child had many substances. What substance gives the measles antibodies in the blood. By the age main signal for insulin synthesis when its of 1 year these antibodies disappeared from concentration changes? the child’s blood. Why were these antibodi- es present in the child’s blood? A. Glucose B. Carbon dioxide A. Acquired natural passive immunity C. Heparin B. Non-specificresistance D. Hemoglobin C. Acquired natural active immunity E. Urea D. Innate immunity E. Artificial immunity 81. Specify the substance that results from the following reaction: 87. A Gram stained smear shows large ≡ −HOH,−−−−−− Hg2+→ oval violet cells that form pseudomycelium. CH CH ? Name these microorganisms: A. Ethanal A. Candida fungi B. Ethanol B. Mucor fungi C. Propanal C. Plasmodium vivax D. Propanone D. Actinomycetales E. Acetic acid E. Penicillium fungi 82. An ophthalmologist has detected 88. Herbarium specimens of medicinal increased time of dark adaptation in a pati- plants are being studied. Which one of them ent. What vitamin deficiency can result in belongs to Rosaceae family? such symptom? A. Crataegus sanguinea A. A B. Melilotus officinalis B. C C. Conium maculatum C. K D. Capsella bursa-pastoris D. B1 E. Polygonum persicaria E. B6 89. When working in the garden, a man 83. Morphologically the herbaceous accidentally cut his hand. The wound plant being studied can be identified remained untreated. Shortly after that the as Convallaria majalis.Toconfirm this Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 10 wounded area developed inflammation wi- A. Heating in the burner flame th accumulation of exudate that contained B. Boiling under 60oC five times numerous viable and degenerate neutrophi- C. Soaking in 1% chloramine-B solution ls. What type of exudate is it? D. Dry heat sterilization under 160oC for 120-150 minutes A. Purulent E. Formaldehyde vapor sterilization B. Serous C. Fibrinous 95. A dry-heat box is used for sterilization D. Hemorrhagic of various materials and instruments in a E. Catarrhal bacteriological laboratory. This sterilizati- on method can be applied to the following 90. A patient presents with persistent fever, objects: with the difference between evening and morning temperature not exceeding 1oC. A. Glass test tubes What type of fever curve is present in this B. Rubber gloves patient? C. Simple nutrient medium D. Wire inoculating loops A. Continuous E. Physiological saline B. Remittent C. Hectic 96. A specialist of the analytical laboratory D. Recurrent performs direct iodometric determination E. Intermittent of ascorbic acid. What indicator is used in this case? 91. Natural peptides can carry out various functions. What bioactive peptide is a major A. Starch antioxidant and functions as a coenzyme? B. Methyl orange C. Diphenylamine A. Glutathione D. Phenolphthalein B. Bradykinin E. Methyl red C. Oxytocin D. Liberin 97. A certain herbaceous plant grows on E. Anserine the meadows of the Carpathian Mountai- ns. It has orange anthodium inflorescences, 92. Gout develops when purine nucleoti- upright stem, and a rosette of basal leaves. de metabolism is disturbed. The doctor Name this plant: prescribed the patient allopurinol that is a competitive inhibitor of: A. Arnica montana B. Cychorium intybus A. Xanthine oxidase C. Calendula officinalis B. Succinate dehydrogenase D. Echinacea purpurea C. dehydrogenase E. Centaurea cyanus D. Lactate dehydrogenase E. Hexokinase 98. What indicator is used for fixing the endpoint of mercurimetric titration? 93. Name the serums made from blood donated by volunteers or reconvalescent A. Thiocyanate complexes of iron(III) donors: B. Fluorescein C. Eosin A. Homologous D. Murexide B. Heterologous E. Potassium chromate C. Autoimmune D. Attenuated 99. Ultraviolet irradiation is used in medici- E. Corpuscular ne in various physiotherapeutic procedures. What mechanism of medicinal action is 94. During skill building session in the fi- characteristic of ultraviolet rays? eld of microbiology, a student performed inoculation of microorganisms into the solid A. Activation of vitamin D synthesis nutrient medium to obtain isolated colonies. B. Activation of drug action How should inoculation loops be sterilized C. Decrease of melanin synthesis in the skin after that? D. Intensification of cell division E. Activation of lipid peroxidation 100. Human body assimilates fats only as emulsions. Vegetable oils and animal fats contained in food are emulsified when exposed to bile (an emulsifier). How does Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 11 interface tension change in this case? A. Temperature increase B. Temperature decrease A. Decreases C. Continuous fever B. Increases D. Compensation C. Remains unchanged E. Latent stage D. First increases, than decreases E. First decreases, than increases 107. Ascarids were detected in a sick child. What changes in leukogram will be the most 101. A patient has a gallstone lodged in the characteristic of helminthiasis? common bile duct, which blocks bile supply to the intestine. What digestive process will A. Eosinophilia be disturbed in this case? B. Basophilia C. Neutrophilia A. Fat digestion D. Lymphocytosis B. Protein absorption E. Monocytosis C. Carbohydrate digestion D. Carbohydrate absorption 108. A man received a radiation dose of E. Protein digestion 30 Gy. He presents with necrotic angina and disorders of the gastrointestinal tract. 102. You are studying a silvery downy plant Blood tests revealed anemia, leukopenia of Asteraceae family,which is rich in essenti- and thrombocytopenia. What stage of acute al oils and bitters. Harvested are the apical radiation sickness is observed in the pati- sprouts with a panicle of small round flower ent? heads. This plant is: A. Manifest illness stage A. Artemisia absinthium B. Prodromal stage B. Arctium lappa C. Latent stage C. Bidens tripartita D. Recovery D. Calendula officinalis E. - E. Chamomilla recutita 109. Neuroleptanalgesia has been appli- 103. A 46-year-old patient presents with ed in a case of cardiac infarction. What hyperactivity of creatine kinase in his blood neuroleptic is most often administered serum. What pathology can be suspected? along with fentanyl? A. Myocardial infarction A. B. Acute pancreatitis B. (Aethaperazinum) C. Chronic hepatitis C. D. Hemolytic anemia D. E. Renal failure E. Sulpiride 104. Among dosage forms there are 110. Select the halogenated antiseptic that numerous disperse systems. Select a free would be preferable for a child to pack in disperse system from the list: the first aid kit, when going to a summer camp: A. Emulsion B. Gel A. Iodine alcoholic solution C. Jelly B. Brilliant green D. Diaphragm C. Copper sulfate E. Membrane D. Methylene blue E. Formaldehyde solution 105. How according to the Pharmacopoeia is pH determined? 111. A patient, who was prescribed famoti- dine to treat , came to A. Potentiometry the pharmacy. What is this drug’s mechani- B. Spectrophotometry sm of action? C. Indicator D. Conductometry A. H2- receptor blockade E. Polarography B. H1- blockade C. Muscarinic receptor blockade 106. A patient is pale, has goose bumps and D. Inhibition of hydrogen potassium ATPase chills. What stage of fever is it characteristic E. Ganglionic receptor blockade of? 112. What is represented by such a pharmacokinetic value of a drug as its bi- ological half-life (T1/2)? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 12

118. Name the ability of a drug to A. Time period in which plasma drug accumulate within the patient’s body: concentration decreases by 50% B. Blood plasma volume cleared of drug A. Cumulation within a time unit B. Antagonism C. Period of total body clearance C. Synergism D. Renal clearance rate D. Habituation E. Correlation between the drug clearance E. Allergy rate and plasma drug concentration 119. What pharmacological effect of 113. A doctor needs to prescribe the pati- acetylsalicylic acid allows its application ent a drug for replacement therapy after in patients with ischemic heart disease for thyreoidectomy. What drug would you prevention of thromboses? recommend? A. Antiaggregant A. L-thyroxine B. Analgesic B. Insulin C. Antipyretic C. Prednisolone D. Ulcerogenic D. Parathyroidin E. Anti-inflammatory E. Thiamazole 120. A 48-year-old patient has been 114. What is the main mechanism of intravenously administered prednisolone benzylpenicillin bactericidal action on the solution to arrest severe attack of bronchi- coccal flora? al . What group of hormonal agents does prednisolone belong to? A. Disturbed synthesis of microbial cell wall B. Inhibition of protein synthesis A. Glucocorticoids C. Disturbed cytoplasmic membrane B. Gestagenic drugs permeability C. Estrogenic drugs D. Activation of macroorganism immune D. Mineralocorticoid system E. Anabolic steroids E. Increased phagocytic activity of leukocytes 121. A doctor has prescribed a nonsteroi- dal anti-inflammatory drug to relieve 115. What mucolytic agent would you inflammation and pain syndrome. Name recommend for the patient with acute this drug: bronchitis to facilitate expectoration? A. Diclofenac sodium A. Acetylcysteine B. Glibenclamide B. C. C. Codeine D. Prednisolone D. Libexin (Prenoxdiazine) E. Calcium chloride E. Hydrocodone 122. A patient suffers from hyperchromic 116. A patient with allergic dermatitis came B12-deficiency anemia. What vitamin to the hospital. What anti-inflammatory and preparation should be prescribed in this anti-allergic drug must be prescribed in this case? case? A. Cyanocobalamin A. Prednisolone B. Riboflavin B. Ethamide C. Vicasol (Menadione) C. Oxytocin D. Thiamine chloride D. Insulin E. Retinol acetate E. Retabolil (Nandrolone) 123. To stimulate birth activity, a certain 117. A patient with bronchial asthma was neurohypophyseal hormone is used. Name prescribed a drug with the mechanism of this hormone: action that is primarily based on the sti- mulation of β2 adrenergic receptors. Name A. Oxytocin this drug: B. Insulin C. Glucagon A. Salbutamol D. Thyroxine B. Adrenaline hydrochloride E. Testosterone C. Droperidol D. Clonidine 124. Sanitary microbiological investigation E. Isadrine (Isoprenaline) of potable water has detected coliphages. Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 13

What conclusion can be made about the sanitary-hygienic status of this water? A. Polyadelphous B. Monadelphous A. Fecal contamination C. Diadelphous B. The water is safe to drink D. Didynamous C. The water is safe to drink after boiling E. Tetradynamous D. Artesian water E. The water is for industrial use only 131. Upon examination of a flower it is determined to have one pistil made up of 125. After a traffic accident the driver single free carpel. Therefore, this gynoeci- presents with increased blood glucose. What um can be identified as: mechanism leads to hyperglycemia in this case? A. Monocarpous B. Apocarpous A. Sympathoadrenal system activation C. Lysicarpous B. Increased production of somatotropic D. Paracarpous hormone E. Syncarpous C. Decreased production of insulin D. Decreased production of glucagon 132. Examination of a 45-year-old man, who E. Decreased tone of parasympathetic for a long time kept to a vegetarian plant- nervous system based diet, revealed him to have negative nitrogen balance. What peculiarity of his di- 126. Quantitative determination of iodi- et has caused such developments? des by Fajans method is performed with adsorption indicators. The following can be A. Insufficient protein content used as an adsorption indicator: B. Insufficient fat content C. Insufficient vitamin content A. Eosin D. Excessive water content B. Methyl orange E. Excessive carbohydrate content C. Phenolphthalein D. Diphenylamine 133. After severe emotional strain a 53- E. Murexide year-old man suddenly developed acute pain in the heart area, which irradiates to 127. Pharmacopoeia reaction of potassium the left hand, to the neck, and under the ferrocyanide with zinc cations produces: left scapula. He noted numbness of his left hand. His face is pale and covered in A. White precipitate cold sweat. Nitroglycerine administration B. Red precipitate stopped the pain attack after 10 minutes C. Violet precipitate had passed. What is the most likely disease D. Yellow precipitate in this case? E. Black precipitate A. Angina pectoris 128. Rapid analysis of benzoate ions by B. Stroke means of Pharmacopoeia reaction with C. Myocardial infarction iron(III) chloride produces: D. Pulmonary embolism E. Somatoform autonomic dysfunction A. Pink-yellow precipitate B. Green precipitate 134. According to the Pharmacopoeia, C. Blue precipitate molecular weight of a high-molecular D. Red precipitate substance should be determined by means E. Black precipitate of: 129. The following is used to determine the A. Viscometry titrant volume in the process of titrimetric B. Potentiometry analysis: C. Nephelometry D. Osmometry A. Burettes E. Cryometry B. Measuring flasks C. Measuring glasses 135. In the process of coagulation by mi- D. Cylinders xtures of different electrolytes, they seem E. Measuring tubes to counteract each other’s effect. Name this phenomenon: 130. A dissected flower has numerous stamens that are united by the stamen fi- laments into several bundles. What is this type of androecium? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 14

A. Antagonism A. Angiotensin-receptor blockade B. Additivity B. Inhibition of angiotensin-converting C. Synergism enzyme D. Mutual coagulation C. Inhibition of phosphodiesterase E. Sedimentation D. Activation of central α-adrenoceptors E. Calcium channel blockade 136. One of the important diagnostic features of garden sage and motherwort is 141. Select the hepatoprotective drugs from their shape of corolla. Their flowers have the list below: the following type of corolla: A. Essentiale (Phospholipides), Thiotriasoli- A. Bilabiate ne B. Thimble-shaped B. No-Spa (drotaverine), papaverine C. Funnelform hydrochloride D. Pseudoligulate C. Allochol, Cholenzym E. Ligulate D. Festal, Panzinorm (Pancreatin) E. Oxaphenamide (Osalmid), Nicodin 137. Investigation of bacterial contaminati- on of indoor air in a pharmacy takes into 142. Hydrochloric acid was added into the account the total number of microorgani- solution under investigation. The resulting sms present in a certain air volume, as well precipitate was filtered, then this filter cake as qualitative content of indoor air mi- was processed with hot water; after the fi- croflora. Name the sanitary-indicative mi- ltrate cooled, KI solution was added into it. croorganisms for indoor air: What cation was present in the solution, if the precipitate was colored yellow? A. Staphylococcus and streptococcus B. Colibacillus A. Pb2+ C. Sarcina B. Ag+ D. Chromobacterium C. Hg2+ E. Fungi and yeasts D. Ca2+ 2+ 138. During ultrasound investigation a pati- E. Ba ent was diagnosed with bilateral renal artery stenosis of atherosclerotic genesis. Speci- 143. At the end of his shift a worker of the steel foundry felt dizziness, his body fy the bioactive substance that due to its o excessive secretion is the key component of temperature increased to 38.5 C.What arterial hypertension pathogenesis in the gi- condition does he present with? ven case: A. Hyperthermia A. Renin B. Decompression B. Cortisol C. Fever C. Vasopressin D. Hypothermia D. Noradrenaline E. Hypertension E. Thyroxin 144. The third analitycal group of cations 2+ 139. Preliminary disinfection of air and (acid-base classification) includes Ca , working surfaces of the equipment was Sr2+, Ba2+. What acid can function as a conducted in the operating room of the precipitator agent (group reagent) for these surgical inpatient unit. What method of cations? sterilization would be the most advisable in this case? A. H2SO4 B. HNO3 A. Ultraviolet irradiation C. HCI B. Irradiation sterilization D. CH3COOH C. High-frequency current E. HCIO4 D. Flowing steam E. Formaldehyde vapor 145. Students should identify the following to determine the sex of a flower: 140. A patient was prescribed losartan for treatment of arterial hypertension. What A. Stamens and pistils does this drug have? B. Flower cup and corolla C. Pedicle and receptacle D. Symmetry E. Color and type of indumentum 146. In spring a perennial plant of Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 15

Asteraceae family produces floral shoots wi- A. Collargol th gloden-yellow flowers. After blossom- B. Sodium sulfate fall, shoots with large leaves appear. Name C. Silver nitrate this plant: D. Potassium gluconate E. Sucrose A. Tussilago farfara B. Нiреriсum perforatum 152. Paracetamol has antipyretic and C. Potentilla erecta analgesic effect. In the human body it is D. Petroselinum crispum neutralized in the following organ: E. stramonium A. Liver 147. Ultramicroscopy is used to determine B. Spleen the radius of dispersed phase particles. The C. Intestine following should be measured to make the D. Lungs necessary calculations: E. Heart A. Number of particles in a definite volume 153. Rhizome of an Asteraceae family speci- B. Intensity of transmitted light es is polycephalous, succulent, has lysi- C. Intensity of scattered light genous cavities, accumulates inulin. Such D. Distance traveled by a tagged particle underground organ is characterisic of: E. Time interval in which a tagged particle travels a certain distance A. Inula helenium B. 148. Permanganatometry is used in determi- C. Digitalis grandiflora nation of many organic and inorganic D. Sorbus aucuparia compounds. What are the main advantages E. Helianthus annuus of permanganatometry over the other oxi- dimetric methods? 154. Silver nitrate solution was added into a solution with anions of the first analytical A. Sufficiently high redox potential; it is group. A yellow precipitate was produced as possible to determine titration end-point the result, which indicates that this solution without indicator contained: B. Sufficiently high stability of potassium permanganate and its solutions A. Arsenite ions C. High selectivity and sensitivity when B. Arsenate ions determining compounds C. Sulfate ions D. Pure potassium permanganate is easily D. Iodide ions available and obtainable E. Bromide ions E. Various types of indicators can be used; 155. Some medicinal plants are poisonous. in some cases catalysts are necessary to Select a poisonous plant from the list below: accelerate the reaction A. Digitalis purpurea 149. Many organic compounds break up B. Origaum vulgare in the cell into simple products. What C. Thymus serpilum compounds break up into ammonia, carbon D. Salvia officinalis dioxide, and water in the human body? E. Thymus vulgaris A. Amino acids 156. What cation can be detected with B. Monosaccharides Chugaiev’s agent (Dimethylglyoxime)? C. Monohydric alcohols D. Fatty acids A. Ni2+ E. Keto acids B. Ca2+ + 150. A fruit is a capsule with oblate li- C. D. Mn2+ ght brown smooth glossy seeds that mucify 2+ when moistened. This fruit belongs to: E. Co A. Linum usitatissimum 157. A patient in the state of ketoacidotic B. Hypericum perforatum coma presents with loud rapid respirati- C. Ledum palustre on: labored expiration with tension of expi- D. Linaria vulgaris ratory muscles occurs after deep inspiration. E. Digitalis purpurea Name this type of pathologic respiration: 151. What substance forms colloid solution when dissolved in water? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 16

A. Kussmaul’s 161. Specify the products of urea hydrolysis: B. Cheyne-Stokes’ C. Gasping D. Stenotic E. Biot’s 158. In a nursery-garden some medicinal plants developed signs of a disease: there A. CO +2NH are yellow spots and necrotic foci on the 2 3 B. CO2 + N2 +3H2 leaves. Sap of the diseased plants remai- C. CO +2NH ned infectious even after passing through 3 D. CO + N2 +3H2 a bacteria-excluding filter. No microorgani- E. CO + N +3H O sms growth was detected on the nutrient 2 2 2 medium. What microorganisms could be the 162. Specify the products obtained as the cause of this disease? result of formic acid being heated with concentrated sulfuric acid: A. Viruses B. Fungi C. Ray fungi D. Bacteria E. Mycoplasma A. CO + H O 159. A laboratory received ethanol and 2 B. CO2 + H2O methanol. What reaction can be used to di- C. CO + CO + H O stinguish between these two substances? 2 2 D. CO2 + H2 E. CO + H2 A. Iodoform test (I2 + NaOH) B. Beilstein test 163. Transformation C H (alkene) −→ C. Formation of a chelate complex with 2 4 copper hydroxide C2H6 (alkane) occurs during the followi- ng reaction: D. Oxidation (CrO3, H2SO4) E. Reaction with halogen anhydrides of A. Hydrogenation inorganic acids B. Dehydrogenation C. Dehydration 160. Select pyridine from the listed D. Hydration compounds: E. Dimerization A. 164. Hydrolysis reaction will NOT occur wi- th: A. Glycerol B. Starch B. C. Cellulose D. Fat E. Protein 165. What reaction proves that phenol has acidic properties?

C.

D.

E. Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 17

A. A. Rimantadine B. Methisazone C. D. Idoxuridine E. Doxycycline

B. 169. A woman complains of itching lips; they are reddened and covered in scabs and scales after she had been using new lipstick for two weeks. What allergic reactions result in this kind of disorders? A. Delayed B. Cytotoxic C. C. Immune complex D. Anaphylactic E. Stimulating 170. Choose the potent fast-acting diuretic to induce forced diuresis: D. A. Furosemide B. Hydrochlorothiazide C. Spironolactone D. Triamterene E. Acetazolamide 171. Name the psychostimulant with E. analeptical action, which is a purine deri- vative: A. Caffeine and sodium benzoate B. C. Medazepam D. Sodium bromide 166. Select ketose from the monosacchari- E. Sulpiride des listed below: 172. After ishemic stroke the patient was A. Fructose prescribed a drug to improve his intellectual B. Glucose functioning and memory. What drug would C. Mannose he obtain in the pharmacy? D. Arabinose E. Ribose A. Piracetam B. Metoclopramide 167. According to Hueckel’s rule an organic C. Tabex () compound will have aromatic properties if: D. Diphenin (Phenytoin) A. Its molecular structure contains a planar E. - cycle with a closed conjugated system that 173. A patient with a small cut on the palm contains (4n+2) of pi electrons, where n = came to the dispensing chemist. What anti- 0,1,2,3, etc. septic would be advisable in this case? B. Its molecules are composed exclusively of carbon and hydrogen atoms that form a A. Hydrogen peroxide linear carbon chain B. Doxycycline hydrochloride C. There is only one substituent in the C. Ketoconazole molecule D. hydrochloride D. There are condensed nuclei in the E. Flemoxin (Amoxicillin) molecule E. There is a cyclohexane ring in the 174. Mother of a 10-year-old child came to molecule the pharmacy to obtain a drug for preventi- on of upper respiratory tract infections. 168. A pharmacy has received a batch of What drug would be recommended by the drugs for treatment of upper respiratory dispensing chemist? tract infection. What drug is used to treat influenza? Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 18

A. Interferon B. Benzoteph A. C. Carvedilol D. Tetracycline E. Doxorubicin 175. A patient came to the pharmacy to obtain an antidiarrheal agent. What drug B. would be recommended by the dispensing chemist? A. Loperamide B. Dicaine () C. C. D. Picolax (Sodium picosulfate) E. Anesthesin () 176. A patient came to the pharmacy to obtain a drug that contains pancreatic D. enzymes and can be taked for chronic pancreatitis. What drug would be recommended by the dispensing chemist? A. Pancreatine B. Triamcinolone C. Gordox (Aprotinin) E. D. E. Omeprazole 177. Increased concentration of acti- ve oxygen forms is a mechanism of pathogenesis in a number of diseases. To prevent this process, antioxidants are 181. When an isolated system spontaneously prescribed. Select an antioxidant from the approaches its equilibrium, its entropy: list below: α A. Approaches zero A. -tocopherol Approaches infinity Glucose B. B. C. Reaches maximum C. Calciferol Reaches minimum Cobalamine D. D. E. Demonstrates linear magnification E. Glicerol 182. A pharmacy produces a batch of vials 178. A 28-year-old man with peptic ulcer of with physiological saline for injections. How the stomach was prescribed a drug that inhi- should they be sterilized? bits gastric juice secretion. Specify this drug: Under pressure in an autoclave Omeprazole A. A. B. In a steam-jacketed autoclave chamber Ethacrynic acid B. C. In a dry heat sterilizer C. Duphalac (Lactulose) D. X-ray irradiation D. Lidocaine E. Ultraviolet irradiation E. Fenofibrate 183. A certain dioecious plant commonly 179. An engine driver complains of his grows at the forest edge. It is a shrub with seasonal allergy symptoms. What non- thorned sprouts. Its fruit is a round black sedating drug should be prescribed in this coenocarpous drupe (pyrenarium) with 3-4 case? seeds. Name this plant: Loratadine A. A. Rhamnus cathartica B. Novocaine Hippophae rhamnoides Fenofibrate B. C. C. Crataegus sanguinea D. Analgine (Metamizole) D. Rosa canina Atenolol E. E. Sambucus nigra Salicylic acid derivatives are widely 180. 184. Choose the weakest carboxylic acid used in medicine. Specify the formula of basing on its pKa value: salicylic acid: Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 19

A. Propionic acid (рКа = 4.9) A. Suberization B. Acetic acid (рКа = 4.7) B. Lignification C. Formic acid (рКа = 3.7) C. Mineralization D. Lactic acid (рКа = 3.9) D. Cutinization E. Butyric acid (рКа = 4.82) E. Mucification 185. Which of the amines listed below is a 191. Specify the analgesic that affects opi- primary amine? ate receptors and can cause development of tolerance and dependence: A. C H CH NH 6 5 2 2 A. B. C6H5CH2NHCH3 C. C H NHCH B. Phenobarbital 6 5 3 C. Medazepam D. C6H5N(CH3)2 E. C H CH N(CH ) D. Voltaren (Diclofenac sodium) 6 5 2 3 2 E. 186. It can be safely assumed that the infants born from the mothers with the history of 192. During furosemide therapy of a pati- measles will not be affected by the measles ent with chronic edematous syndrome, his outbreak during their stay in the materni- plasma-cation concentration was disturbed. ty ward. What classes of antibodies provide What drug should be used in this case? the infants with the resistance to this di- A. Potassium chloride sease? B. Thiamine bromide A. IgG C. Ascorutin (Ascorbic acid + Rutoside) B. IgA D. Magne B6 C. IgD E. Aspirin D. IgM 193. Upon examination the ophthalmologi- E. IgE st diagnosed a 21-year-old woman with vi- 187. The children attending a kindergarten sual impairment - hemeralopia (”night bli- were hospitalized with diagnosis of poli- ndness”). What drug should this patient omyelitis. What was the route of infection take to restore her vision? transmission in this case? A. Retinol acetate A. Fecal-oral transmission B. Ergocalciferol B. Alimentary transmission C. Suprastin (Chloropyramine) C. Direct contact transmission D. Cholecalciferol D. Transmission via airborne dust particles E. Sustac forte (Nitroglycerin) E. Vector-borne transmission 194. What bonds participate in creation of 188. What ion increases osmotic pressure in both linear and cyclic dimeric carboxylic the focus of inflammation? acid associates? A. Potassium B. Calcium C. Fluorine D. Magnesium E. Chlorine A. Hydrogen bonds B. Ionic bonds 189. A 55-year-old man came to a doctor wi- C. Polar covalent bonds th complaints of acute pain in his big toes. D. Nonpolar covalent bonds Meat and wine are a permanent fixture in E. Donor-acceptor bonds his diet. The doctor suspects gout. What substance must be measured in the patient’s 195. Heating of sodium phenolate in blood to confirm this diagnosis? CO2 stream results in production of a certain carboxylic acid. Name the resulti- A. Uric acid ng compound: B. Urea C. Lactate A. Salicylic acid D. Bilirubin B. Ethyl salicylate E. Ketone bodies C. Phenyl salicylate D. Benzoic acid 190. Name the process of cell membrane E. Aminophenol saturation with a fat-like substance - suberin: 196. Which alkadiene of those listed below Krok 1 Pharmacy (англомовний варiант, iноземнi студенти) 2018 рiк 20 is a diene with cumulated double bonds?

A. CH2 = C = CH2 B. CH3 − CH = CH − CH2 − CH = CH2 C. CH2 = CH − CH2 − CH = CH2 D. CH2 = CH − CH2 − CH2 − CH = CH2 E. CH2 = CH − CH = CH2 A. 4-О-(α-D-glucopyranoside)-α-D- 197. What compound will be produced as glucopyranose the result of chlorination in the B. 4-О-(α-D-glucopyranoside)-β-D- presence of FeCl3 catalyst? glucopyranose C. 4-О-(β-D-glucopyranoside)-α-D- glucopyranose D. 4-О-(β-D-glucopyranoside)-β-D- glucopyranose E. α-D-glucopyranoside-β-D- fructofuranoside

A. 199. What compound is synthesized as the result of β-picoline oxidation?

A. Nicotinic acid B. B. Benzoic acid C. Uric acid D. Barbituric acid E. Ascorbic acid 200. Specify quinoline among the compounds given below: C. A.

B. D.

C.

E. D.

E.

198. Select α-maltose from the list:

INSTRUCTIONAL BOOK

Testing Board

TEST ITEMS FOR LICENSING EXAMINATION: KROK 1. PHARMACY.

Kyiv. Testing Board. (English language).

Approved to print 14.05./№45. Формат 60х84 1/8 Offset paper. Typeface. Times New Roman Cyr. Offset print. Conditional print pages 24. Accounting publishing pages 20. Issue. 162 copies.

List of abbreviations

A/G Albumin/globulin ratio A-ANON Alcoholics anonymous ACT Abdominal computed tomography ALT Alanin aminotranspherase AP Arterial (blood) pressure AST Aspartat aminotranspherase BP Blood (arterial) pressure BR Breathing rate bpm Beats per minute C.I. Color Index CBC Complete blood count CHF Chronic heart failure CT Computer tomography DIC Disseminated intravascular coagulation DCC Doctoral controlling committee DM-2 Non-Insulin dependent diabetes mellitus DTP Anti diphtheria-tetanus vaccine ECG Electrocardiogram ESR Erythrocyte sedimentation rate FC Function class FEGDS Fibro-esphago-gastro-duodenoscopy Gy Gray GIT Gastrointestinal tract Hb Hemoglobin HbA1c Glycosylated hemoglobin Hct, Ht Hematocrit HDL High-density lipoproteins HRIDDM HeartInsulin rate dependent diabetes mellitus IHD Ischemic heart disease IU International unit MSEC Medical and sanitary expert committee NIDDM Non-Insulin dependent diabetes mellitus pCO2 CO2 partial pressure pO2 O2 partial pressure Pm Per minute Ps Pulse rate R Roentgen RBC Red blood count Rh Rhesus RR Respiratory rate S1 (S1) Heart sound 1 S2 (S2) Heart sound 2 TU Tuberculin unit U Unit USI Ultrasound investigation V/f Vision field WBC White blood count X-ray Roentgenogram