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Home , Azidomorphine, Bufetolol, Bulbocapnine, Bupicomide, Bupranolol, Butidrine

233 Index Vol. 16-23

The references of the Subject Index are given in the language of the respective contribution. Die Stichworte des Sachregisters sind in der jeweiligen Sprache der einzelnen Beitrage aufgeftihrt. Les termes repris dans la Table des matieres sont donnes selon la langue dans laquelle l'ouvrage est ecrit.

A 17 Abortion, therapeutic 457,460 23 Acetylsalicylic acid (®) 114 20 Academic research 169 16 O-Acetylserin-Sulfhydrylase A 390 18 Acanthocheilonema perstans 142 17 Acetylstrophanthidin 35 18 Acanthocheilonema streptocerca 142 22 Achromycin® () 53 22 Acaprin® (quinuronium sulfate) 42 19 Acidosis 529 20 33, 36, 229 18 Acid phosphotase 66 18 Acedapson (Hansolar®, 4',4"'-sulfonylbis• 16 Aconitase-Isomerase 436 ) 108, 156 17 35,46 17 Acedist® (bromfenofos, Ph 1882) 113, 134, 17 Acranil 119, 152 278 17 Acrichine® (quinacrine) 119 18 Aceperone 437 17 Acridine 295 16 Acetacetat-Decarboxylase 414 16 Acriftavin 100 17 2-Acetamido-5-nitrothiazole 261 17 Acrolein 358 17 Acetanilide 23, 497 18 Acronine 440 20 Acetanilide 400 21 Acrosin 366 23 Acetanilide 212 21 Acrylamide 186 20 (Diamox®) 209,417 17 Actamer® () 114,297 21 - 114 22 Actamer® (bithionol) 46 22 (Dymelor®) 81 16 Actinomycin I 298 17 Acetohydroxamic acid 348 16 Actinomycin IV 298 17 13, 17 16 Actinomycin V 298 16 260 17 Actinomycin C, (actinomycin D) 376 17 2-Acetoxy-4' -chloro-3,5-diiodobenzanilide 16 Actinomycin D (actinomycin C" (clioxanide) 114,135,164,277,281 dactinomycin) 89, 118 17 a-Acetoxyheptanoic acid 416 17 - 273,302,376 17 7-Acetoxy-4-oxo-dodecanoic acid 416 20 - 467,474 16 4-Acetylaminobenzenesulfonamide 254 21 - 199 16 3-Acetylaminophenanthrene 259 22 - 132 16 2-Acetylamino-4-phenylthiazole 259 23 - 38 16 4-Acetylaminopropiophenone 254 22 Aculeacin A 131 22 Acetylaranotin 309 21 Acute toxicity 212 16 219,335,340 23 N-Acyl-L-amino acid esters 141, 152 17 Acetylcholine 46 20 5'-O-Acyl-ara-cytidines 588 19 Acetylcholine 148 16 Acyl hydroxylation 231 20 Acetylcholine 335, 410 17 I-Acyl-3-(2-thiocarbamoyl-5- 20 335 thiazolyl)urease 262 20 Acetylcholine receptor function 337 20 Adalat® (nifedipin) 407 20 Acetylcholine receptor isolation 336 22 Adamantane derivatives 277 16 219,336,370,410 19 Adenine 468 20 Acetylcholinesterase 108, 324 21 Adenocarcinoma 243 16 Acetylcholinesterase activity 355 19 cyclic-Adenosine monophosphate 16 inhibitors 170 (adenosine 3',5'-monophosphate, cyclic• 16 Acetyl Co-A-Carboxylase 420 AMP) 511 20 N-Acetylcysteine 480 20 - 272,329 16 N-Acetylmuramyl-I-alanine amidase 328 23 - 43 22 N-Acetylneuraminic acid 307 16 Adenosin-Desaminase 408 20 Acetylsalicylic acid (Aspirin®) 400 16 Adenosintriphosphatase 412,414,438 234 Index Vol. 16-23

17 Adenosinetriphosphatase 299 20 Aldophosphamide 468 17 Adenosine triphosphate (ATP) 62 16 Aldose-Reductase 390 19 Adenosine triphosphate (ATP) 511 22 (Aldocorteneill» 68, 76 20 Adenosine triphosphate (ATP) 272 20 Aldosterone antagonists 213 16 AdenosyJmethionin-Decarboxylase 396 16 Alfalfa Mosaikvirus 384 19 Adenovirus 280 16 ALG (Antilymphocyte globulin) 102, 123 20 Adenylate cyclase 329 18 409 21 Adenylate cyclase 412,414 22 Alkeranill> (melphalan) 63 16 Adenylat-Kinase 390 16 Alkohol-Dehydrogenase 388,392,400 19 Adenylcyclase 511,567 23 Alkylammonium compounds 120 20 Adenylcyclase 274 17 2-Alkyl-I,2,3,3a,4,5- 16 Adenyl-Succinase 406 hexahydroimidazo[l,5-a] 254 20 Adiphenine (Trasentineill» 420 16 N-(3-Alkyl-5-nitro-4-thiazolin-2- 20 410,418 ylidene)amides 19,20 20 a- blockers 199 22 N-Alkylnorpethidines 169 19 p-Adrenergic blockers 361 23 N-Alkylpiperidines 171 20 p-Adrenergic blockers 222 23 4-Alkylpyridines 103 20 p- 340 23 N-Alkylpyridinium compounds 171 16 Adrenocortical microsomes 262 23 N-n-Alkyltritylamines 122 17 Adriamycin 374 23 Allamandin 83 18 Adriamycin 441 16 Allanosine 90 20 Adriamycin 467, 474 17 Allantoin 340 22 Adriamycin 67 20 Allercurill> () 426 18 Adriamycinone 441 20 589 18 Aedes aegypti 284 18 Allergic reaction 255 18 Aedes polynesiensis 264 20 589 17 A elurostrongylus abstrusus 178 18 453 21 AF 1890 [1-(2,4-dichlorobenzyl)-indazole- 19 Allobarbitone 210,225 3-carboxylic acid] 354 17 Allopurinol (Zyloprimill» 340 21 AF 1312/TS (I-p-chlorobenzyl-IH- 20 - 402 indazole-3-carboxylic acid) 353 17 Allylthiourea (thiosinamine) 274 20 Affinity constants 136 22 Alpenill> (ampicillin) 50 20 445 22 Alphaprodine (Nisentilill» 172 22 Afridol violet 38 22 254, 255 16 Ag-Ab (Antigen-antibody complex) liS 16 355 19 Agglutination test 179,556 20 Alprenolol 33, 36, 226, 229, 230 23 Agglutination test 17 20 p-Alprenolol 227 20 Agglutinin 328 16 ALS (Antilymphocyte serum) 101 23 Agglutinin 16 22 Altafurlll> (furaltadone) 45 23 Agglutinogens 21 19 hydroxide 613,618 23 AIPF (anaphylactoid inflammation 23 Aluminium hydroxide IS promoting factor) 38 19 Aluminium phosphate 265 16 Alanyl-tRNA-Synthetase 400 20 Alupentill> () 419 17 Alazopeptin 324 16 (Symmetrelill» 347 22 Albegoill> () 242 20 - 423 22 Albucidill> (sulfacetamide) 31 22 - 62.277 17 94 16 Ambilharlll> () 14 17 Alcoparill> (bephenium 20 Ambilharill> (niridazole) 448 hydroxynaphthoate) 130 22 Ambilharill> (niridazole) 47 20 Alcoparill> (bephenium 17 Amebarsinill> (diphetarsone) 123 hydroxynaphthoate) 451 18 Amebic disease, pathogenesis 225 22 Alcoparlll> (bephenium 22 Amenoroneill> () 73 hydroxynaphthoate) 47 20 American trypanosomiasis (Chagas 22 Aldactoneill> () 76 Disease) 446 16 Aldehyde dehydrogenase 246,442 22 Amethopterinill> (methotrexate) 64 20 Alderinill> () 411 16 w -Amidase 388 22 Aldocorteneill> (aldosterone) 76 22 Amidines 299 16 Aldolase A 402 17 Amidostomum anseris 171 16 Aldolase B 402 20 Amidoximes 214 20 Aldometill> (a-) 411 22 Amikacin (Amikinill>, Biklinill» 57 17 Aldophosphamide 357 22 Amikinill> (amikacin) 57 Index Vol. 16-23 235

20 (Midamor®) 213,417 18 Amiperone 437 17 Amino acids 82 20 Amiphenazole (Daptazole®) 397 22 Amino acids 308 20 (Elavil®, Laroxyl®) 394 16 4-Aminobenzenesulfonamide 16 Amitryptilinemethyliodate 352 (sulfanilamide) 259 18 (Camoquin®) 102, 103, 143 19 p-Aminobenzoic acid 286 20 - 435 21 p-Aminobenzoic acid 191 22 - 42 17 6-Amino-2,4-bis(trichloromethyl)-1,3- 18 78,225,278,355 benzodioxan 286 19 Amoebiasis 570 16 y-Aminobutyric acid 221,222,290,339, 20 Amoebiasis 438 348 18 Amoebiasis, exfoliative 82 20 y-Aminobutyric acid receptor 341 18 Amoebiasis, surgical problems 79 16 e-Aminocaproic acid 88, 118 18 Amoebicidal , evaluation 353 16 l-Aminocyclopentane carboxylic acid 20 Amoebicides 438 (cycloleucine) 88 18 Amoeboma 83 22 6-Amino-6-deoxy-o-glucose 307 17 Amoebotaenia sphenoides 299 17 4-Amino-4-deoxypteroic acid 325 18 Amopyroquine (Propoquin®) 102 22 5'-Amino-2',5'-dideoxy-5-iodouridine 296 22 Amoxicillin (Amoxil®) 50 17 2-Amino-5-( diethylamino ) 260 22 Amoxil® (amoxicillin) 50 17 2-Amino-4,7-dimethoxy-6- 20 cyclic-AMP (cyclic adenosine 3',5'• thiocyanatobenzothiazole 272 monophosphate) 272,329,580,585 22 (Elipten®) 77 21 - 414 22 2-Amino-4-hydroxypyrimidines 276 16 AMP (adenosin monophosphat) 17 5-Aminoimidazole-4-carboxamide 336, desaminase 410 338 16 AMP Nucleosidase 398 16 b-Aminolaevulinsllure-Dehydratase 440 16 (Benzedrine®) 217,341,346 18 2-Amino-5-( l-methyl-5-nitro-2-imid• 20 - 397,418 azolyl)-1,3,4-thiadiazole 327 22 Amphetamine derivatives 363 17 4-Amino-2-methyl-N-(5-nitro-2-thiazolyl)- 16 d-Amphetamine 347 5-pyrimidinecarboxamide 262 16 I-Amphetamine 347 17 2-Aminomethyltetrahydroquinolines 252 18 290, 320 21 6-Aminonicotinamide 199 20 Amphotericin B 441,443,444 17 trans-5-Amino-3-[2-(5-nitro-2-furyl)vinyl]- 22 Amphotericin B 59, 97, 103, 132 1,2,4-oxadiazole (SQ 18506) 267 16 Ampicillin (Alpen®, Penbritin®, 17 6-Amino-N-(5-nitro-2-thiazolyl)-m- Polycillin®) 313 toluamide 263 19 - 539 16 Aminopeptidase 414 22 - 50 20 (Pyramidon®) 401 20 Amplivix® (benziodarone) 407 17 N-(p-Aminophenyl)-N',N'- 20 Amprotropine (Syntropan®) 420 dimethylacetamidine 309 16 a-Amylase 388 16 Aminopterin 93, 118 16 p-Amylase 406 17 Aminopterin 324 20 Amylene hydrate 387 18 Aminopterin 107 22 Amylobarbitone 360 20 Aminopterin 471 16 iso-Amylphenylketone 262 22 6-Aminopyrazolo[4,3-c]pyridin-4(5H)- 22 Anadrol® () 69 one 289 17 Anaemia, haemolytic 64 17 4-Aminopyrazolo[3,4-d] 343 20 Anaesthetics 386 17 7-Aminopyrazolo[4,3-d]pyrimidine 343 22 antagonists 150 23 1-(3-Amino-4-pyridyl)-4-aryl- 22 150 213 23 Anaphylactoid inflammation promoting 17 Aminopyrine 490 factor (AIPF) 38 17 4-Aminopyrrolo[2,3-d]pyrimidine 344 20 589 18 4-Aminoquinolines 101, 104 22 Anavar® () 70 18 p-Aminosalicylic acid (PAS) 212 17 Ancaris® (thenium) 130 22 p-Aminosalicylic acid (PAS) 34 22 Ancef® (cefazolin) 53 16 d-Aminosllure-Oxidase 396 22 Ancobon® (flucytosine) 36 16 I-Aminosllure-Oxidase 400 17 Ancylol® (disophenol) 131 21 Aminosidine 129, 179 17 Ancylostoma braziliensis 163,184 21 Aminotetralin derivatives 429 18 Ancylostoma braziliensis 199 17 5-Amino-v-triazole-4-carboxamide 336 17 Ancylostoma caninum 160 22 4-Aminotwistanes 280 18 Ancylostoma caninum 199 236 Index Vol. 16-23

19 Ancylostoma ceylanicum 64 16 Antibacterial action 51 16 Ancylostoma duodenale 163, 165 23 Antibacterial activity 217 17 Ancylostoma duodenale 160, 161 21 Antibacterial agents 11 18 Ancylostoma duodenale 198 22 Antibakterielle Chemotherapie 328 19 Ancylostoma duodenale 8,17,25,36,46,64, 18 Antibiotics 415 70,81,86,90,96, 161, 173 19 Antibiotics 186, 450 20 Ancylostoma duodenale 453 23 Antibiotics 51 17 Ancylostoma tubaeforme 163 19 Antibiotics tests 574, 598 19 Ancylostomiasis 2, 141 22 Antibiotika 328 16 ANDA (Abbreviated New 22 Antibiotika, bakterielle Resistenz 334 Application) 201 22 Antibiotika, Beurteilungsgrundlagen 337 22 Androcur® ( ) 70 22 Antibiotika, Bewertung 327 17 24 22 Antibiotika, Bioverfiigbarkeit 339 20 Anectine® (suxamethonium) 422 22 Antibiotika, Dosierung 344 17 Anelmid® (dithiazanine) 127 22 Antibiotika, Entwicklung 328 20 Anergy 361 22 Antibiotika, Halbwertzeit 343 20 Angina pectoris 36 22 Antibiotika, Konzentration 343 20 589 22 Antibiotika, Mikrobiologie 337 18 Angiostrongylosis 196 22 Antibiotika, Nebenwirkungen 350 18 A ngiostrongylus cantonensis 195 22 Antibiotika, Pharmakokinetik 338 18 Angiostrongylus vasorum 196 22 Antibiotika, Resistenztypen 336 20 Angiotensin 245 22 Antibiotika, Wechselwirkungen 352 18 Angolamycin 422 20 Antibody 14 23 Anguidin 81 23 Antibody 13 17 Anhydro-7-chlorotetracycline 232 19 Antibody titres 542 22 169 23 Anticancer activity 218 17 Aniline 17 17 Anticancer agents 322 20 Aniline lost glucuronioe 563 20 Anticancer agents 467 17 Ankilostin® (tetrachlorethylene) 130 20 Anticancer agents, activation 555 22 Anodynin 200 17 Anticancer agents, 386,387 18 Anopheles balbacensis 249 20 Anticancer agents, toxicity 479 18 Anopheles culicifacies 248 19 Anticholera immune serum 547,551 18 Anophelesfunestus 174 19 Anticholera immunization 482 18 Anopheles gambiae 174,283 19 Anticholera vaccine 584 18 Anopheles minimus 101 16 drugs 342 18 Anopheles philippinensis 248 20 Anticholinergic drugs 420 18 Anopheles stephensi 248 20 Anticholinergic esters 124 17 Anoplocephala magna 154 19 Anticholinesterase effect 329 22 Anspor® (cephradine) 53 20 Anticoagulants 404 17 Antabuse 360 20 Anti-epileptic drugs 424 20 (Antistin®) 426 23 activity 211 20 Antepar® () 451 22 Antifungal agents 93 20 Antergan® () 424 22 Antifungal agents, drug combinations 132 16 activity 168 16 Antigen 70, 72 16 Anthelmintic agents 158 19 Antigen 180,279,471,475 18 Anthelmintic agents 192, 198 20 Antigen 14 17 Anthelmintic agents 110 23 Antigen 13 19 Anthelmintic agents 147, 166 19 Antigen electrophoresis 122 20 Anthelmintic agents 348 19 Antigen fractionation 119 19 Anthelmintic agents, screening 48, 55 19 Antigen purification 125, 128, 131,280 19 Anthelmintic drugs toxicity 172 16 Antigen-antibody complex (Ag-Ab) 115 17 Anthiolimine (Anthiomaline®) 112, 183 16 Antigen reactive cells (ARC) 70 17 Anthiomaline® (anthiolimine) 112,183 20 424 22 Anthiphen® (dichlorophene) 46 23 Antihistaminic activity 220 23 Anthralin 67 20 Anti-humanthymocyte globulin 581 16 Anthranilat-Synthetasekomplex 410,436 20 Antihyperlipidaemic agents 417 17 Antiarrhythmic drugs 36 23 Antihypertensive activity 216 17 Antiarrhythmic drugs, classification 51 20 Antihypertensive agents 198,236,407 17 Antiarrhythmic drugs, 20 Antihypertensive chemotherapy 199 45 20 Antihypertensive combinations drugs 246 17 Antiarrhythmic effect 36 23 Anti-inflammatory activity 215 Index Vol. 16-23 237

17 Antiinflammatory agent 470 17 Ara-A (9-P-o• 18 Anti-leishmanial agents 332 arabinofuranosyladenine 345 18 Antileprotic agent 159 20 Ara-A (9-p-o• 16 Antilymphocyte globulin (ALG) 102, 123 arabinofuranosyladenine 478 16 Antilymphocyte serum (ALS) 101 22 Ara-A (9-P-o• 20 Antilymphocyte serum (ALS) 581 arabinofuranosyladenine 292 23 Antimalarial activity 210 17 9-p-o-Arabinofuranosyladenine 18 Antimalarial drugs 101 (ara-A) 345 20 Antimetabolites, anticancer activity 470 20 9-p-o-Arabinofuranosyladenine 16 activity 315 (ara-A) 478 20 Antiminth® ( pamoate) 451 22 9-p-o-Arabinofuranosyladenine 18 Antimonic acid 306 (ara-A) 292 17 dimercaptosuccinate (Astiban®, 17 I-p-o-Arabinofuranosylcytosine stibocaptate, TWSb/6) 112, 140, 143, 182 (ara-C) 332,341 17 Antimony sodium gluconate 20 I-p-o-Arabinofuranosylcytosine (Triostam®) Ill, 140 (ara-C) 472 17 Antimony sodium tartrate (Stibunal®, 22 I-p-o-Arabinofuranosylcytosine Emeto-Na®) Ill, 140, 183 (ara-C) 293 17 Antimosan® () 112 17 I-p-o-Arabinofuranosylcytosine,5'• 16 Antineoplastic agents 88 adamantoate 335 16 Antiproliferative agents 75 22 I-p-D-Arabinofuranosylthymine 16 Antiproliferative drug 86 (Ara-T) 294 21 Antipsychotic drugs 412 16 L-Arabinose-Isomerase 414 20 Antipyretics 400 17 ara-C (l-p-o• 20 Antipyrine () 401 arabinofuranosylcytosine) 332,341 16 Antischistosomal drug 14 20 ara-C (l-p-o• 18 Antischistosomal drug 16 arabinofuranosylcytosine) 472 16 Antistaphylococcal drugs 320 22 ara-C (l-p-o- 20 Antistin® (antazoline) 426 arabinofuranosylcytosine) 293 19 Antitetanus immunoglobulin 398 17 430 19 Antitetanus serum 210,289,330,362,375, 16 Arachin 380 381,393 20 ara-Cytidine 584 20 Anti-thymocyte gammaglobulin 583 22 Aralen® () 42 16 Antithymocyte globulin (ATG) 74, 124 22 Aranotin 309 16 Antithymocyte serum (ATS) 74 22 Ara-T (l-p-o- 19 Antitoxin 324 arabinofuranosylthymine) 294 19 Antitoxin titers 609 16 ARC (antigen reactive cells) 70 18 Antituberculous drugs 213 16 ARC, stimulation of 75 16 Antitumor action 51 17 121 18 Antitumor agents 23 20 Afronad® (trimetaphan camsylate) 409 23 Antitumor agents 65 16 Arginase 398,436 23 Antitumor agents 65 18 Arginine 426 17 Antiverm® () 131 16 Arginin-Decarboxylase 418 22 Antiviral agents 267 16 Arginin-Succinase 406 20 Antrenyl® (oxyphenonium ) 420 22 Aristocort® () 75 22 Antrycide® (quinapyramine) 42 17 Arrhythmia 34 17 Antrypol® ( sodium) 132 17 Arsenamide (thiacetarsamide, 20 - 445 Caparside®, Caparsolate®) 122, 181 20 Anturan® (sulfinpyrazone) 401 20 Arsobal® (, Mel B®) 445 19 Anuria 508 22 Arsobal® (melarsoprol, Mel B®) 40 20 Anxiety 38 18 Arsphenamine (Salvarsan®) 331 17 Aphesal 297 22 - 37 22 Aphidicolin 312 17 Arthrobacter colchovorum 382 16 Apoferritin 380 18 Arthropod-borne disease 45 16 342 16 Arylamidase 408 21 Apomorphine 411 16 Arylaminedecarboxylase 336 21 Apomorphine analogs 425 20 Arylbutenes 111 18 Appendicitis, amoebic 84 22 3-Arylpiperidines 187 20 Apresoline® () 408 20 Arylpropenes III 20 Apronalide (Sedormid®) 387 20 Arylpyrrolidines 71 238 Index Vol. 16-23

16 Arylsulfatase A 396 17 Atmungsferment 496 17 Arylthiohydantoins 290 20 Atopy 589 22 Anneimittelinteraktionen 352 22 Atoxyl® (sodium arsanilate) 40 22 Arzneimittel, klinische 17 ATP (adenosine triphosphate) 62 Untersuchungen 329 19 ATP (adenosine triphosphate) 511 17 Ascariasis 155 20 ATP (adenosine triphosphate) 272 18 Ascariasis 192 17 ATPase 63 19 Ascariasis 15,30, 141, 167 16 ATP-Sulfurylase 414 20 Ascariasis 451 17 Atrioventricular node 44 20 Ascaris 355 20 Atromid-S (clofibrate) 418 18 Ascaris cuticulum 192 16 217,341 19 A scaris 30 20 Atropine 335 16 Ascaris lumbricoides 163, 165,293 16 Atropinmethylnitrate 352 17 Ascaris lumbricoides 157 16 ATS (antithymocyte serum) 74 18 Ascaris lumbricoides 191 22 Aureomycin® (chlorotetracycline) 53 19 Ascaris lumbricoides 17,29,30,81, 161 19 Autonomic dysfunction 245 16 Ascaris suis (suum) 167 20 Auxins 112 17 Ascaris suis (suum) 155 19 Auxotrophic mutants 467 17 Ascarotrat® (tetramisole) 125 16 Avidin 376 23 Ascites cell 141 17 A vitellina centripunctata 294 16 Ascorbic acid (vitamin C) 284 17 A vitellina woodlandi 294 17 Ascorbic acid (vitamin C) 490 22 Avlosulfone® (dapsone) 33 22 Ascorbic acid (vitamin C) 84, 85 17 8-Azaadenine 336 23 Ascorbic acid (vitamin C) 51 18 Azacrine dihydrochloride 146 20 Asian fluke disease 450 16 5-Azacytidine 96 22 Asparaginase (Crasnitin®) 67 17 5-Azacytidine 326 16 L-Asparaginase 110, 128,400,436 20 5-Azacytidine 471 20 L-Asparaginase 476 17 6-Azacytidylic acid 328 16 Aspartase 404,438 17 6-Azacytosine 328 16 Aspartat-Aminotransferase 394, 396,436 16 8-Azaguanine 94 16 Aspartat-p-Decarboxylase 418 17 8-Azaguanine 335 16 Aspartat-Kinase 398 17 8-Azaguanosine 336 16 Aspartat-Kinase-I-Homoserin-I- 17 8-Azaguanylic acid 335 Dehydrogenase 414 17 2-Azahypoxanthine 370 16 Aspartat-Transcarbamylase 412 17 8-Azahypoxanthine 336 23 Aspergillus niger 211 17 8-Azainosine 336 16 Aspergillus sclerotiorum 31,37, 57 17 8-Azainosinic acid 336 17 Aspergillus sclerotiorum 245 20 Azamethonium bromide 18 Aspergillus sclerotiorum 16 (Pendiomid®) 201,409 19 Asphyxia 320 17 5-Azaorotic acid 326 17 Aspidin (polystichin) 120, 148 17 5-Azaorotidylic acid 326 16 Aspirin® (acetylsalicylic acid) 98 18 437 17 Aspirin® (acetylsalicylic acid) 433,470 22 Azaribine (Triazure®) 64 19 Aspirin® (acetylsalicylic acid) 253 16 Azaserine 88 20 Aspirin® (acetylsalicylic acid) 400 17 Azaserine 323 21 Aspirin® (acetylsalicylic acid) 199 20 Azaserine 470 17 462 16 Azathioprine (Imuran®) 88, 92, 94, 103, 20 Asthma 589 119 21 Asthma 243 17 - 341 17 Astiban® (stibocaptate) 112 20 - 583,584 22 Astiban® (stibocaptate) 47 17 5-Azauracil 326 17 Asuntol® () 129 16 6-Azauracil 96 17 Atabrine® (quinacrine) 119 17 6-Azauracil 327 20 Atarax® () 392 17 5-Azauridine 326 17 Atebrin® (, quinacrine) 294 16 6-Azauridine 98, 123 20 Atebrin® (mepacrine, quinacrine) 441 17 6-Azauridine 327 22 Atebrin® (mepacrine, quinacrine) 38 17 5-Azauridylic acid 326 20 (Tenormin®) 34,36,237,411 17 6-Azauridylic acid 327 16 ATG (Antithymocyte globulin) 74,124 17 8-Azaxanthine 335 17 Atherosclerosis 39 22 Azidocodeine 156 22 Ativan® () 242 22 156 Index Vol. 16-23 239

16 Azoferredoxin 376 21 Bentropine 412 22 Azomycin 45 22 Benzalkonium chloride (Zephiran 17 4-Azo-l-naphthylamines 258 chlorideill) 29 21 Azathioprine 351 19 Benzathine penicillin 246 17 Azotomycin 324 20 Benzedrexill (propylhexedrine) 419 20 Benzedrineill (amphetamine) 397,418 B 17 Benziform® (carbon tetrachloride) 116 17 Bacillus subtilis 370 23 Benzilonium n-alkylsulfonates 118 18 Bacillus subtilis 21 16 159 16 Bacitracin 314 22 Benzimidazoles 108,281 22 Bacitracin 59 20 Benziodarone (Amplivixill) 407 20 (Lioresalill) 423 22 Benzitramid 195 21 Bacterial agents 176 16 Benzoazolureas 95 20 Bacterial 355 20 (Tacitine®) 393 21 Bacteriostatic agents 167 22 - 362 16 Bacterium subtilis 51 21 Benzo[6,7]cyclohepta[I,2,3- 22 Bactocillill (oxacillin) 50 de]pyrido[2,I-a] 447 19 Bactonutrient broth 466 22 story 229 22 Bactrimill 22 1,4-Benzodiazepin-2-one 4-oxides 241 (sulfamethoxazole + thrimethoprim) 33 17 7,8-Benzoflavone 16 22 Bakterielle Infektionen 328 16 Benzofuroxan 95 20 BAL (dimercaptol) 446 22 4,5-Benzo[hept-l,2,6-oxdiazines] 232 20 441 16 Benzoic acid 260 20 Balantidium coli 441 17 Benzoins 300 17 Banancrisill (thenium) 130 23 Benzomorphan 203 17 Banminthill (pyrantel) 124 22 6,7-Benzomorphans 159 22 Banminthill (pyrantel) 48 20 Benzomorphan derivatives 110 17 Banminth II () 124 21 Benzophenone 191 20 Bamethan (Vasculatill) 411 23 Benzophenone 110 17 Banocideill () 127 23 2H-l,2,4-Benzothiadiazine-l,l• 20 Banocideill (diethylcarbamazine) 455 dioxides 216 20 Banthineill (methantelium bromide) 420 16 Benzothiopyrano-[4,3,2-cd]indazoles 40 17 76 17 2H-[1]Benzothiopyrano[4,3,2- 18 Barbiturates 432 cd]indazoles 249 19 Barbiturates 324 17 Benzphetamine 18 22 Barbiturates 366 17 3,4-Benzpyrene 494,497 17 Bathocuproine 14 17 Benzpyrene-hydroxylase 495 20 2502 (Lampitill) 446 16 Benzthiazoles 95 17 Bayer 4059 (brotianide) 284 23 Benzyldimethylalkylammonium 17 Bayer 9015 (menichlopholan, compounds 185 Bilevon-MiIl) 278 17 2-Benzylidene-4-cyclopentene-l ,3- 17 Baytexill () 128 dione 309 16 BCND [bis(chlorethyl)nitrosourea] 86 16 Benzylmethylketone 262 16 Bean leaves 281 22 I-Benzylnorpethidine 168 22 Beconaseill (beclomethasone 17,21- 23 Benzyloxyarylacetic acid 220 dipropionate) 74 16 Benzylpropylketone 262 22 Beclomethasone 17,21-dipropionate 16 Bephenium (Alcopar®, Befeniol®, (Propadermill, Beconaseill) 74 Frantin®, Naftamonill) 158, 170 17 Befeniol® (bephenium 17 - 130, 158, 161, 168, 171, 175 hydroxynaphthoate) 130 19 - 33,36,40,70,73,86,90,92,103,150,166 17 Bemarsalill (diphetarsone) 123 20 - 451 20 Bemegride (Megimideill) 397 22 - 47 22 Bemidome 171 18 290,326 20 (Suavitilill) 392 19 Berberine 510,519,520 20 Benadryli1l () 424 20 Berberine 444 20 (Naturetin®) 417 19 Berberine sulphate 520 20 Benemidill (probenecid) 402 20 Berberine sulphate 444 18 Benperidol 437 22 Berenil® (diminazene) 42,45 19 Bentonite 75 23 Betacoccus arabinosacerus 30 19 Bentonite flocculation test 76 19 (Betnelan®, 19 Bentonite suspension 76 Celestoneill) 374, 380 240 Index Vol. 16-23

20 Betamethasone (Betnelan®, Celestone®) 17 1,5-Bis(p-methylaminophenoxy)-pentane 446,456 dihydrochloride 286 22 - 74 17 Bithin® (bithionol) 114 22 Betamethasone 17-valerate (Betneval®) 74 17 Bithionol [Actamer®, Bithin®, Bitin®, 2,2'• 20 (Esbatal®) 215,410 thiobis(4,6-dichlorophenol)] 114, 148, 149, 21 - 357 152, 153, 154,278,297 22 Betnelan® (betamethasone) 74 20 - 447,451 22 Betneval® (betamethasone 17-valerate) 74 22 - 46 18 BHC (l,2,3,4,5,6-hexachlorocyclo- 17 Bithionol sulfoxide (Bitin-S) 114, 134, 149, hexane) 248,267 150,278,297 16 Bicillin 319 17 Bitin® (bithionol) 114 16 222 20 Bitin® (bithionol) 447 18 Bikaverin 323 17 Bitin-S (bithionol sulfoxide; 2,2'• 22 Biklin® (amikacin) 57 sulphinyl(4,6-dichlorophenol) 114,278, 22 Bilarcil® () 47 297 23 Bile salts 118 16 Bitoscanate (Biscomate®, Jonit®, 1,4- 17 Bilevon® (hexachlorophene) 114 phenylenediisothiocyanate, phenylene 17 Bilevon-M® (Bayer 9015, thiocyanate) 158, 171 menichlopholan) 278 17 - 131, 158, 163 18 Bilharsiasis 15,200 19 - 2,6,23,52,60,64,70,71,81,86,90, 23 Bilinear model 168 91,96, 166 17 Bilirubin 489 22 - 49 17 Bilirubin synthesis 489 17 Bitriben® (hexachloroparaxylol) 117 17 Bindschedler's Green 260 22 Blenoxane® (bleomycin) 67 20 Biochemical blockade 15 20 Bleomycin (Blenoxane®) 474 22 Biochemical II 22 Bleomycin (Blenoxane®) 67 20 Biochemistry 17 17 Bleomycin A 379 20 Bioisoterism 12 17 Bleomycin B 379 20 Biological activity 12 20 Blockadren® () 36 23 Biological activity 98, 148,200 20 P-Blocking agents 28 20 Biological cell systems 262 20 P- Blocking agents, contraindications 38 16 Biological evaluation 199 20 P- Blocking agents, investigation 29 17 Biological membrane 88 20 P-Blocking agents, pharmacology 31 21 Biological response 117 20 P-Blocking agents, side actions 39 21 Biological response quantification 107 19 Blood examination 129 20 Biological stereoselectivity 104 20 Blood glucose concentration 548 20 Biological transport mechanism II 23 BOL-148 (2-bromo-d-Iysergic acid 20 Biomembrane 263 diethylamide) 40 20 Biomembrane processes 275 22 Bonaid® (buquinolate) 34 21 Biophase 108 23 Bondapak C-18® 125 18 Biopterin 299 22 Bonaphthone 278,301 20 Bioreceptors 14 19 Bordetella bronchiseptica 181,260 20 Biosynthesis 13 19 Bordetella parapertussis 181,257 19 Biotin (vitamin H) 286 19 Bordetella pertussis 178, 257, 348 22 Biotin (vitamin H) 86 23 Bordetella pertussis 12, 15,45 16 Biotincarboxylase 436 19 Bordetella pertussis serotypes 260, 348 23 Biphenyl 110 20 Bovine pleuropneumonia 355 17 2,2'-Bipyridine 14,18 16 Bovine serum albumin (BSA) 107 21 Birnberg bow 329 19 Bowel 473 17 2,2' -Bis-(p-acetamidophenoxy)ethyl 16 Brain 212,282,354 (diamfenethide, diamphenethide, 19 Brain tissue 302 Coriban ®) 118, 137, 286 20 Brethine® (terbutalin) 419 17 2,4-Bis( 4-arylpiperazino )-3- 21 Brethylium 357 pentanones 252 20 Brinaldix® () 417 21 N,N'-Bis(dichloroacetyl)-1,8- 16 BRL 1288 (2-[Ethyl-n-propylamino]ethyl- octanediamine (WIN 18446) 352 a,a-diphenylglycolate HCI) 342 16 Bis(chlorethyl)nitrosourea (BCNU) 86 22 (Lexotanil®) 250, 262 17 1,3-Bis(2-chloroethyl)-I-nitrosourea 367 16 Bromegrass Mosaikvirus 382 17 Biscomate® (bitoscanate) 131 21 17 P- Bromoacetoxy-19-nortestosterone 336 17 Bishydroxycoumarin 25 16 Bromfenofos (bromofenfos, Acedist®, 17 Bis(2-hydroxy-3-nitro-5- Ph 1882) 168 chlorophenyl)sulphide 280 Index Vol. 16-23 241

17 Bromfenofos (bromofenfos, Acedistill, 16 2-n-Butyloctadecanoic acid 236 Ph 1882) 113, 134, 168,278 16 2-n-Butyltetradecanoic acid 236 21 16a-Bromoacetoxyprogesterone 336 16 y-Butyrobetaine 290 22 5-Bromodeoxycytidine 296 16 y-Butyrolactone 348 21 2-Bromo-a-ergocryptine 432 16 262 22 5-Bromo-2'-deoxyuridine 295 21 Butyrophenone 411 23 2-Bromo-d-lysergic acid diethylamide (Bol- 21 Butyrophenone derivatives 449 148) 40 20 108 17 4'-Bromo-y-resorcylanilide (resorantel, 17 Butyrylperazine 75 Terenol®) 284, 298 17 B.W.65-54[DL-erythro-a-(3,4- 17 Brotianide (3,4'-dibromo-5- dichlorophenyl)-p -(t-butylamino)• chlorothiosalicylanilide acetate, Bayer propanol HCI) 25 4059,I>irian®) 115,136,284 17 Bymix® (coumaphos) 129 17 Broxolin® () 123 20 Brucella abortus 356 C 18 Brucellosis 279 21 353 19 Brucellosis 280 19 521 20 Brufen® () 402 20 Caffeine 396 17 Brugia malayi 180 22 Caffeine 367 18 Brugia malayi 142, 174,201 23 Caffeine 114 20 Brugia malayi 455 22 Calcitonin 77 18 Brugiapahangi 151 16 338 16 BSA (Bovine serum albumin) 107 17 Calcium arsenate 293 17 Buban® (bunamidine) 121,302 22 Calcium elenolate 306 19 Bubonic plague 347 22 Camazepam (Albego®) 242 22 Buclosamide 129 16 Cambendazole 159, 160 18 Bufalin 431 17 Cambendazole 126, 157, 163, 167, 169, 177 20 226 18 Camolar® ( pamoate, CI- 22 (Silubin®) 80 501) 107, 156 19 Bulbar Tetanus 220 20 Camolar® (cycloguanil pamoate, CI- 16 346 501) 435 20 (Burinex®) 211,417 22 Camolar® (cycloguanil pamoate, CI- 17 Bunamidine (Buban®, Scolaban®) 121, 501) 44 148, 149, 152, 154, 155,302 18 Camoquin® (amodiaquine) 102, 143 20 a- 335,339 22 Camoquin® (amodiaquine) 42 20 227 22 Camptothecin 313 20 Bunolol 34, 36, 228 22 Canaline 308 20 241 20 Cancer 36, 362, 364, 466 20 226 20 Cancercell 482,532 20 (Temgesic®) 55 20 Cancer cell glycolysis 548 22 - 156,157,211 20 Cancer chemotherapy 465 22 Buquinolate (Bonaid®) 34 20 Cancer combination chemotherapy 484 20 Burirnnamide 427 20 Cancer multistep therapy (CMT) 536 20 Burinex® (bumetanide) 417 20 Cancer therapy 532 16 Bushy stunt-Virus 384 20 Cancer tissue capillaries 553 16 Busulfan (Myleran®) 86 20 Cancer tissue overacidification 550, 553, 17 - 337,365 563 20 - 469 20 Cancerostatica effects 524 22 - 64 20 Cancerostatica molecular weight 543 21 415,417 20 Cancerostatica concentration 544 17 Butanol 74 20 Cancerostatica side effects 524 20 Butazolidine® (phenylbutazone) 401 20 Cancerostatic drugs 523, 533, 551 20 32 20 Cancerostatic drugs, combinations 532 18 Butirosin A 422 20 Cancerostatic drugs, action 523 18 Butirosin B 422 20 Cancerostatic drugs, cycle phase 20 62, 89 specificity 527 22 Butorphanol 163 20 Cancerostatic drugs, dosage 535 20 Butoxamine 28, 32, 227 20 Cancerostatic drugs, effective dose 547 18 Butropipazone 437 20 Cancerostatic drugs, pharmacokinetic 17 4-Butylaminobenzofg) 295 aspects 540 20 Butydrin 225 20 Cancerous tissue 525 20 Cancerous tissue, damage 551 242 Index Vol. 16-23

22 105 16 Catechol-O-methyltransferase 345 16 Candida bogoriensis 265 18 Catharanthus roseus 414 22 Candidin 95 18 Catharosine 411 22 Canesten® (c1otrimazole) 36 17 Cation transport 65 16 224 22 Cefazolin (Ancef®, Kefzol®) 53 17 Canopar® (thenium) 130 22 Cefoxitin(Mefoxin®) 53 17 Caparside® (arsenamide, 22 Celbenin® (methicillin) 50 thiacetarsamide) 122 22 Celestone® (betamethasone) 74 17 Caparsolate® (arsenamide, 20 Cell cycle 482, 523 thiacetarsamide) 122 16 Cell proliferation 74,75,76 17 Capillaria feliscati 159 16 B cells 73 19 Capillaria hepatica 58 16 T cells 73 17 Capillaria obsignata 159 20 Cell transport mechanisms 263 17 Capillaria philippinensis 159 16 Cellular immunity 73 18 Capillaria philippinensis 195 19 Cell-wall antigen 612 20 Capillaria philippinensis 454 19 Cell-wall antigen preparation 620 17 Capillariasis 159 22 Celospor® (cephacetrile) 53 18 Capillariasis 196, 202 21 Centchroman 324 20 Capillariasis 454 16 Central nervous system (CNS) 195 18 Capreomycin 212 19 Central nervous system (CNS) 301 22 Caprokol® (hexylresorcinol) 46 20 Central nervous system (CNS) 20 Captagon® (fenetylline) 396 stimulants 396 20 (Panparnit®) 420 22 Cephacetrile (Celospor®) 53 16 219,343 22 Cephalexin (Ceporex®, Kefiex®) 53 18 (Tegretol®) 459 19 Cephalic tetanus 443 20 - 394 19 Cephalic tetanus, clinical data 444 16 Carbamylphosphat-Synthetase 410 19 Cephalic tetanus, diagnosis 444 22 Carbenicillin (Pyopen®, Geopen®) 51 19 Cephalic tetanus, EMG data 447 22 Carbimazole (Neomercazole®) 77 19 Cephalic tetanus, treatment 444 20 (Clistin®) 424 22 Cephaloglycin (Kafocin®) 53 20 Carbochromen (Intensain®) 407 22 Cephaloridine (Ceporin®, Loridine®) 53 21 Carbon disulfide 187 22 Cephalosporin C 52 17 Carbon tetrachloride (tetrachloromethane, 16 Cephalothin (Kefiin®) 314 Benziform®, Necatorina®) 116, 136,276 22 - 53 22 - 46 22 Cephradine (Anspor®, Velosef®) 53 22 Carbopol 273 22 Ceporex® (cephalexin) 53 16 Carboxydismutase 416 22 Ceporin® (cephaloridine) 53 17 2-( 6-Carboxyhexyl)-3-octylcyc1opent-2- 16 Ceruloplasmin 378 enone 417 17 Cestodes 119 16 Carboxylesterase 370,404 17 Cetarsol® (drocarbil) 121 16 Carboxypeptidase G, 436 16 CFR (Code of Federal Regulations) 196, 22 (Nadisan®, Invenol®) 80 207 21 Carcinoma 317 20 Chabertia 350 16 Carcinostatic activity 51 20 (american 20 Cardiac agents 404 trypanosomiasis) 446 18 Cardiac arrhythmia 393 21 Chemical 343 19 Cardiac arrhythmia 247 23 Chemical structure 98, 200 17 Cardiac cells 34 23 Chemical structure 200 17 Cardiac glycosides 66 22 (Yatren®) 42 20 Cardiazol® (pentetrazole) 397 16 Chinolinsaure-Phosphoribosyl- 17 Cardiolipine 78 Transferase 402 20 Cardiomyopathy 37 20 Chiral centers 123 17 Caricide® (diethylcarbamazine) 127 20 Chlamydial infections 355 20 392 20 Chloralhydrate 387 22 Carmustine 64 17 Chlorambucil (Leukeran®) 349 16 Carnitine 290 20 - 584 23 Carrageenan 33, 34 21 - 351 19 Casoni's Test 77 22 - 63 20 Catapresan® () 413 22 Chloramine T 29 16 Catatonia 345 16 (Chloromycetin®) 90, 17 Catecholamine 35 1I8,318 Index Vol. 16-23 243

17 Chloramphenicol (Chloromycetinlll» 26, 17 2-Chloroethyl isocyanate 367 488 17 1-(2-Chloroethyl)-3-(trans-4- 18 - 331 methylcyclohexyl)-l-nitrosourea 367 19 - 511,519 17 76 21 - 174 23 Chloroform 104 22 - 54 16 4-Chloroglycolanilide 256 16 d-Chloramphetamine 347 22 Chloroguanide (, Paludrinelll» 44 16 l-Chloramphetamine 347 16 Chlorolactanilide 252 18 Chlorasquin 116 22 Chioromycetinlll> (chloramphenicol) 54 17 25 17 2' -Chloro-4'-nitrosalicylanilide 297 22 131 16 4-Chlorooxanilic acid 256; 258 18 (Libriumlll» 434 16 4-Chlorooxanilid 256, 258 20 - 393 18 Chloropentafiuoroethane 390 22 - 230,238,362 29 Chlorophene 29 22 Chlordiazepoxide, degradation 238 16 Chlorophenesin 99 18 Chlorguanide 107,328 16 4'-ChlorophenyIacetanilide 263 22 301 16 p-Chlorophenylalanine 220 21 a-Chlorhydrin 355 18 1-(p-Chlorophenyl)-3-[4-amino-6-(tri• 20 (Ecolidlll» 202, 409 fiuoromethyl)-2-pyrimidinyl]guani• 21 acetate dines 147 (Gestafortinlll» 300, 308 18 1-(p-Chlorophenyl)-3-(4-{[2-( diethyl• 22 - 74 amino )ethyl]amino}-6-methyl-2- 22 Chlormethine (Dichiorenlll» 63 pyrimidinyl) (ICI-3,349) 132 22 Chlormidazole 109 17 1-(p-Chlorophenyl)-3- • 16 4-Chloroacetanilide 254,256,257,259 pentanimidoylurea 307 16 Chloroambucil 118 16 4-Chloropropionanilide 251,253 16 4-Chloroaniline 257 17 6-Chloropurine 340,347 21 I-p-Chlorobenzyl-lH-indazol-3-carboxylic 20 (Synopenlll» 426 acid (AF 1312/TS) 353 16 Chloroquine (Aralenlll» 100 17 4-Chloro-a ,a'-bis( 5-chloro-2- 18 - 103,184,249,324,363 hydroxyphenyl)-2,6-xylenol (0-610) 295 19 - 52 17 5-Chloro-N -(6-chloro-l ,2,3- 20 - 435,439 benzothiadiazol-7-yl) 299 22 - 42 17 3' -Chloro-4' -(p-chlorophenoxy)-3,5- 18 Chloroquine diphosphate 102 diiodosalicylanilide (rafoxanide, 22 Chlorotetracycline (Aureomycin®) 53 Flukanidelll>, Novazolelll>, Ranidelll» 115, 20 (Diurillll» 210,417 135,165,272,282,283,298 16 3-Chlorothioxanthenone 35 17 3-Chloro-4-(p-chlorophenoxy)-4'• 17 Chlorothricin 69 nitrocarbanilide 273 17 N'-(3-Chloro-p-tolyl)-N ,N- 16 Chlorocruorin 382 diethylethylenediamine (mirasan) 250 17 7-Chloro-5a,l1a-dehydro-6- 22 (Tracelll» 72 epitetracycline 222 20 Chlorozotocin 480 17 7-Chloro-6-demethyl-tetracycline 231 22 Chlorphenesin 130 17 11a-Chloro-6-demethyltetracycline 218 16 Chlorpheniramine (Chlor-Trimeton®) 342, 16 6-Chloro-5-diethylaminoethylamino-8- 347 hydroxymethyl-quinoline 58 20 - 426 16 6-Chloro-5-diethylaminoethylamino-8- 18 Chlorphenoxamide 361 methyl-quinoline 58 16 (Largactil®) 91,344,345 17 6-Chloro-5-{[2-( diethylamino )ethyl]• 17 - 23,25,490 amino}8-methylquinoline 18 - 433,455 (RD 12.869) 254 19 - 210,225,246,289,323,330,362,439 17 8-Chloro-2-[-2-(diethylamino )ethyl]-2H• 20 - 389 [ 1]benzothiopyrano[4,3,2-cd]indazole-5- 21 - 413 249 23 - 117 17 4' -Chloro-3,5-diiodosalicylanilide, acetate 22 (Diabineselll» 81 of (2-acetoxy-4' -chloro-3,5- 23 - 38 diiodobenzanilide, clioxanide, 20 (Taractan®) 389 Tremeradlll» 114,135, 164,277,281 22 128 17 1-(2-Chloroethyl)aziridine 353 17 Chlortetracycline (7-chlortetracycline) 211, 20 1-(2-Chloroethyl)aziridine 468 214,217,228,231,234 17 1-(2-Chloroethyl)-3-cyclohexyl-l• 18 - 331 nitrosourea 367 244 Index Vol. 16-23

20 Chlorthalidone (Hygroton4O) 210,417 18 CI-50l (cycloguanil pamoate, 20 Chlor-Trimeton4O (chlorpheniramine) 426 Camolar4D) 107, 156 17 Chloxyle4O (hexachloroparaxylol) 117 18 CI-679 (2,4-diamino-6-[(3,4-dichloro• 17 Choanotaenia infundibulum 299,300 benzyl)nitrosamino lquinazoline 22 Cholecalciferol (vitamin 0 3) 86 acetate) 151 18 Cholera 45 22 CIBA 190640 (thiambutosine) 36 19 Cholera 347,352,471,519,542,578 22 Cibazol4O (sulfathiazole) 31 23 Cholera 12 22 Cicloperox 128 19 Cholera antiserum 516,550 20 427 19 Cholera antitoxin 604 23 Cimetidine 54 19 Cholera bacteriology 514 16 Cinanserin 99 19 Cholera biotypes 517 20 (Nupercaine4O) 403 19 Cholera carrier 594 20 (Stutgeron4O) 426 19 Cholera colonization 564 21 Cinnoline derivates 46 19 Cholera control 503 21 Cinoxacin 46 19 Cholera diagnosis 513 16 Citral acid 242 19 Cholera diarrhoea 543 16 Citrat-Oxalacetat-Lyase 442 19 Cholera enterotoxin 471,478 16 Citrat-Synthase 394,410 19 Cholera epidemiology 510,578,594 19 Citric acid 284 19 Cholera immunity 612 16 d-Citronellic acid 242 19 Cholera incidence 579 22 Clavulanic acid 53 19 Cholera infection 471,490,564, 594 18 Cleavamine 413 23 Cholera infection 13 20 (Tavegyl4O) 424 19 Cholera pandemic 513 20 Clemizole (Allercur4O) 426 19 Cholera pathophysiology 563 22 Cleocin4O () 59 19 Cholera research 503 20 Clindamycin (Cleocin4O) 436 19 Cholera sereotypes 353,517 22 - 59 19 Cholera therapeutics 563 23 Clinical dextran 30, 33 19 Cholera toxin 504,519 20 Clinical evaluation 151 20 Cholera toxin receptor 342 20 Clinical pharmacology 17, 151 19 Cholera toxoid 602 22 Clinical pharmacology II 19 Cholera toxoid lot 00101 603 22 Clinical research 18 19 Cholera toxoid lot 11201 605 22 Clinical studies 10 19 Cholera toxoid purification 605 21 Clinical trials 246 19 Cholera toxoid research 602 20 Clinoril4O () 402 19 Cholera treatment 503 22 (Vioform4O) 42 19 Cholera vaccines 275,277,278,353,481, 16 Clioxanide (2-acetoxy-4'-chloro-3,5- 503,509,547,550,554,602 diiodobenzanilide, 4' -chloro-3,5- 23 Cholera vaccines 13 diiodosalicylanilide acetate, 23 Cholera vibrios 13 Tremerad4O) 172 16 Choleragen 430 17 - 114,135,164,277,281 16 Cholesterin-Esterase 414 20 Clistin40 (carbonoxamine) 424 17 72, 77 22 (Urbanyl4O) 258 20 Cholesterol 287,296 22 Clofazimine (Lamprene4O) 38 20 Cholestyramine (Questran4O) 418 20 Clofibrate (Atromid-S) 418 16 Cholinacetylase 335 18 Clofluperidol 437 16 mechanisms 335 21 308,321 16 336 22 Clomid4O (clomiphene) 72 19 Cholinesterase 329 22 Clomiphene (Clomid4O) 72 19 Cholinesterase inhibitor 329 22 365 16 Choriogonadotropin 374 22 (Clonopin4O) 261 16 Chorismatmutase-Prephenat- 20 Clonidine (Catapresan4O) 220,413 Dehydrogenase 390 23 - 217 21 Chronic toxicity 135, 164 22 Clonopin4O (clonazepam) 261 16 Chymotrypsin 112, 388 17 Clonorchiasis 138,276 23 Chymotrypsin 141, 152 17 Clonorchis sinensis 138, 276 16 Chymotrypsin-Inhibitor 374 18 Clonorchis sinensis 196 17 CI-407 (5-(4-{l2- 20 Clonorchis sinensis 450 (diethylamino )ethyllamin

21 Cloprostenol 326 21 Copper T 330 22 (Tranxene®) 245 17 Co-Ral® (coumaphos) 129 20 210 20 Coramine® (nikethamide) 397 20 Clorindione (Indalitan®) 404 23 Corasil C-18® 125 19 Clostridium diphtheriae 241, 336 17 Coriban® (diamphenethide, 16 Clostridium histolyticum 293 diamfenethide) 118,286 19 Clostridium tetani 241,392 17 Coronary occlusion 39 19 Clostridium tetani growth 384,386 17 Corpus luteum 458 19 Clostridium tetani spores 388 16 91 19 Clostridium welchii 546 20 Corticosteroids 584 22 257 21 Corticosteroids 243 22 (Canestan®, Lotrimin®) 36, 22 Corticotropin 79 109, 117 18 () 429 16 Cloxacillin (Orbenin®, Tegopen®) 314 22 Cortisol (hydrocortisone) 68, 74 22 - 50 18 429 22 (Sepazon®) 252 20 Cortisone 454, 475 20 (Leponex®) 391 22 Cortisone 74 21 - 413 22 (Diaster®) 75 20 CMT-Selectines 553 16 Corynebacterium diphtheriae 287 16 CNS (Central nervous system) 195 19 Corynebacterium diphtheriae 283 23 CNS activity 212 23 Corynebacterium parvum 15 16 Coagulase 314 17 Corystibin® (stibophen) 112 17 75 22 Cosmegen® (dactinomycin) 67 20 Cocaine 403 17 Cotugnia digonopora 294 20 Coccidosis 438 20 Coumadin® (warfarin) 404 16 Code of Federal Regulations (CFR) 196, 16 Coumaphos (Baymix®, Co-Ral®, 207 Asuntol®) 168 22 152 17 - 129,158,159,163 23 Codeine 116 17 Coumarin 493 22 152 17 Coumarin metabolism 493 22 Colcemid® (demecolcin) 64 22 Crasnitin® (asparaginase) 67 16 Colchicine 85, 86 18 Crilhidiajasciculata 299 20 Colchicine 403, 585 20 Crohn's disease 361 21 Colchicine 351 20 Cromolyn sodium (lntal®) 427 22 Colchicine 64 23 Crotepoxide 77 19 Coliform bacilli 280 16 Crotonase 402 16 Collagen 378 16 a-Crustacyanin 380 16 Collagen biosynthesis 292 16 p-Crustacyanin 380 16 Collagenase 293 16 y-Crustacyanin 380 23 Collander equation 102 18 Culexjatigans 174,271,284 23 Colocynthin 68 18 Culex pipiens 260 20 Combantrin® (pyrantel pamoate) 451 19 250,296,324 18 Communicable diseases 44,278 19 Curarisation 248 18 Communicable diseases control 44,46, 17 Cyanacethydrazide (Cydrazin®, 243,278 Dictycide®, Neohydrazid®) 131,177 19 Complement fixation test 124, 133 17 Cyanide 496 19 Complement fixing antibody 179 22 Cyanidol 312 16 Concanavalin A 112,370, 376,430 17 4-Cyano-2-iodo-6-nitrophenol (nitroxynil, 20 Concanavalin A 328 Trodax®) 117,136,278,280 23 Concanavalin A 33, 35, 38, 139 17 Cyanuric acid 361 22 Congasine (Surfen C®) 42 17 Cyclase reaction, modulators of 468 22 Conteben® (thiacetazone) 34 20 76,81,93 21 Contraception 295 22 Cyclazocine 160 17 Contraceptive 457 20 Cyclazocine glucuronide 77 21 Contraceptive action 309 20 (Marezine®) 426 21 Contraceptive pill 244 22 Cyclocytidine 294 21 Contraceptive vaccines 359 18 Cycloguanil pamoate (Camolar®, CI- 23 Convolvulin 71 501) 107, 156,327,328 19 Convulsions 305 20 - 435,444 21 Copper Lippes Loop 332 22 - 44 21 Copper seven 331 23 Cyclohexane 105 246 Index Vol. 16-23

17 Cyclohexylisocyanate 367 17 Dactinomycin (actinomycin, Cosme- 16 Cycloleucine (I-aminocyclopentane gen®) 376 carboxylic acid) 88 22 - 67 22 Cyclooctylamine hydrochloride (SKF 22 Daktarin® () 36 23880A) 279 21 Dalkon® shield 334 20 (N avidrex®) 417 22 Dalmane® (llurazepam) 261 16 Cyclophosphamide (Cytoxan®, 21 349 Endoxan®) 86,103,117 20 Danilone® (phenindione) 404 17 - 305,306,350 20 Dantrium® (dantrolene) 422 20 - 468,583 20 Dantrolene (Dantrium®) 422 21 - 199,351 22 Daoni\® () 81 22 - 64 18 Dapolar® (acedapson + cycloguanyl 17 I'C-Cyclophosphamide 356 pamoate) 108, 157 18 Cyclophosphoramide 23 18 Dapsone (Avlosulfone®) 155, 159 23 Cycloprotobuxine-C 86 20 - 435 20 60 22 - 33 18 Cycloserine (Seromycin®) 212 20 Daptazole® (amiphenazole) 397 22 - 55 20 Daraprim® () 435 20 210 22 Daraprim® (pyrimethamine) 44 17 Cydrazin® (cyanacethydrazide) 131 21 Darbid® 357 20 (Periactin®) 426 20 Darvon® () 399 23 - 40 22 - 189 21 Cyproterone 22 Daunoblastine® (daunorubicin) 67 22 (Androcur®) 70 18 Daunomycin 441 18 Cyrofluorane 20 Daunomycin 474 (dichlorotetraftuoroethane) 378 18 Daunomycinone 441 16 Cystathionase 438 17 Daunorubicin (Daunoblastin®) 373 16 Cystathionin-Synthetase 410 22 - 67 16 Cystathionin-)l-Synthetase 402 17 Daunorubicinol 374 16 Cysteamin-Oxygenase 394 17 Davainea proglottina 299 20 L-Cysteine 480 20 DCI (dichbroisoproterenol) 28,32,224 16 Cystein-Synthetase 412 16 dCMP (Deoxycytidin Monophosphat) 18 Cysticercosis 279 Aminohydrolase 398 20 Cysticercosis 448 16 DDT [I, 1,1-Trichloro-2,2-bis-(p-chloro• 22 Cytarabine (Cytosar®) 64 phenyl)ethane; dichlorodiphenyltrichlo• 16 ara-Cytidine 96, 103, 123 roethane 1 351 16 Cytidintriphosphat-Synthetase 396 17 - 497 20 Cytochalasin B 586 18 - 248,267,284 22 Cytochalasin B 311 21 -.124, 185 19 Cytochrome 308 16 DDT-dehydrochlorinase 436 17 Cytochrome a, 492 16 DDVP () 158, 168 16 Cytochrome bs 248 17 Deacetylcolchicine 381 17 Cytochrome bs 497 18 Deacetylvindoline 411 16 Cytochrom cc' 432 20 Death, causes of 501 16 Cytochrom f 378 20 Death statistics 494 16 Cytochrom C-Oxydase 404 17 7-Deazainosine 345 16 Cytochrome P-450 248,306 22 Debenal® () 31 17 Cytochrome P-450 489 20 (Declinax®) 215,410 19 Cytochromeoxidase 319 22 - 356 17 Cytoplasm 63 18 DEC (diethylcarqamazine) 142,179,201, 16 Cytoplasmaprotein 432 260,275 22 Cytosar® (cytarabine) 64 22 Decadron® () 74 17 Cytosine arabinonucleotide 334 22 Deca-Durabolin® ( deca- 20 Cytostatic therapy 357 noate) 69 20 Cytotoxicity 482 19 Deca-methonium succinylcholine 296 22 Cytoxan® (cyclophosphamide) 64 16 Decane-I, IO-dioic acid 235 17 Cytoxylamine 351 16 Decanoid acid 244,246 19 Decarboxylase media 516 D 19 Decarboxylase tests 515 22 Dacarbazine 64 16 Decarboxylation 277 22 Dactin® 29 20 Decaserpyl® () 408 Index Vol. 16-23 247

20 DeclinaxllD (debrisoquine) 410 20 - 208,408 22 DecodermllD (tluprednylidene acetate) 75 16 DESI (DES Implementation) 201 22 DecortilenllD (prednylidene) 75 16 DES Implementation (DESI) 201 16 Decosanoic acid 267 16 340, 352 23 Decumbrin 88 22 Desipramine 364 16 2-Decylcitrat-Synthetase 436 22 Desmethyldiazepam (MadarllD ) 262 17 Dedimethylamino-7-chloroanhydro-tetra• 17 Desmethylimipramine 25 cycline 224 22 N-Desmethylmethadone 190 17 Dedimethylamino-12a-deoxyanhydro-6- 22 Desoxymethasone (TopisolonllD) 74 demethyltetracycline 224 16 Desoxynucleotid:Polymerase 388 17 Dedimethylamino-6,12a-dideoxyde-car• 19 Desperidine 153 boxamido-7-chlorotetracycline 224 16 Dethiobiotin-Synthetase 388 17 Dedimethylamino-6,12a-dideoxy-6-deme- 19 Deworming 136 thyltetracycline 224 19 Dexamethasone (DecadronllD ) 362 19 Dehydration 504 22 - 74 17 5a, lla-Dehydro-7-chlorotetracycline 232 20 Dexamisole 349 17 113, 133, 141, 144 16 Dexamphetamine 346 18 Dehydroemetine 360 22 Dexamphetamine 364 20 Dehydroemetine 450 23 Dextran 28,30,41 18 2-Dehydroemetine 325 23 Dextrin 47 16 Dehydrogenation 287 22 (PalfiumllD , letriumllD ) 189 17 ll-Dehydroprostaglandin Fl. 439 20 Dextropropoxyphene (DoloxenellD , Dar- 17 DekeIminllD (methyridine) 123 vonllD , DistalgesicllD ) 399 22 DelalutinllD (hydroxyprogesterone 22 - 189 caproate) 73 22 207 22 Delta-9- 365 20 Diabetes, resistance of 329 22 DelvexllD (dithiazanine) 48 22 DiabinesellD (chlorpropamide) 81 17 (6-demethyl-7-chlorote- 17 3',5'-Di-O-acetyl-2' -deoxy-5-tluorouri• tracycline) 211, 228, 236 dine 331 22 Demecolcin (ColcemidllD ) 64 17 Diacetylphenylurea bis(guanyl-hydra- 17 6-Demethyl-6-deoxytetracycline 224 zone) 377 17 6-Demethyltetracycline 216 16 Diacetyl-Reductase 396 18 Dengue 284 17 3',5'-Di-O-acetylthymidine 331 18 Dengue 45 17 2,2'-Diacyloxybenzanilides 298 23 De Novo model 201 17 N-[(Dialkylamino )alkyl)-I,4-naphthalene• 17 3'-Deoxyadenosine 345 diamines 258 17 12a-Deoxyanhydrotetracycline 226 16 a-Dialkylaminosaure-Amino-Trans• 17 2'-Deoxy-5-azacytidine 326 ferase 438 22 Deoxycorticosterone 76 17 N,N-Dialkyl-N'-(I-naphthyl)alkylene• 17 6-Deoxy-6-demethyltetracycline 218 diamines 256 17 2'-Deoxy-5-tluorocytidine 332 17 N,N-Dialkyl-N'-phenyl-N'-[(I,I,2,2- 17 2'-Deoxy-5-tluorouridine 329 tetrachloro-2-tluoroethyl)thio )sulph• 17 2'-Deoxy-5-tluorouridylic acid 329 amides 308 23 2-Deoxyglucose 40 17 Diamfenethide (CoribanllD ) 286 22 2-Deoxy-o-glucose 306 18 2,4-Diamino-6-[(N-alkylanilino )methyl)• 23 Deoxyharringtonine 86 116 17 3'-Deoxyinosine 345 18 2,4-Diamino-6-[(anilino)methyl)quinazo• 17 p-6-Deoxytetracycline 218 lines 116 17 2'-Deoxy-6-thioguanosine 341 18 2,4-Diamino-6-[(aryl and heterocyclic)sul• 17 2'-Deoxy-5-tritluoromethyluridine 332 finyl)quinazolines 121 20 DepakinellD (sodium dipropylacetat) 424 18 2,4-Diamino-6-[(aryl and heterocyclic)sul• 21 Depomedroxyprogesterone acetate fonyl)quinazolines 121 (DMPA) 302 18 2,4-Diamino-6-[(aryl and heterocyclic)• 22 chloride 129 thio )quinazolines 121 20 Dermatitis 589 22 Diaminobenzophenones 274 16 DES (Drug Efficacy·Study) 200 18 2,4-Diamino-6-[(p-chloroanilino)• 16 Desaggregierung 367 methyl)quinazolines 118 17 (RosapinllD) 120, 148 18 2,4-Diamino-6-[(p-chlorobenzyl)oxy)• 16 (HarmonylllD) 352 120 248 Index Vol. 16-23

18 2,4-Diamino-5-(p-chlorophenoxy)-6- 17 N-(2,4-Dichlorobenzylidene)-N'-[2-( di• methylpyrimidine 109 ethylamino )ethyl)-I ,4-naphthalene• 18 2,4-Diamino-6-(p-chlorophenoxy)quin• diamine 256 azoline 121 21 1-(2,4-Dichlorobenzyl)-indazole-3-carbox• 18 2,4-Diamino-6-[(p-chlorophenyl)thio)• ylic acid (AF 1890) 354 quinazoline (WR-135,403) 129 18 Dichlorodiftuoromethane 384 18 2,4-Diamino-6-[(3,4-dichlorobenzyl)ami• 17 5,5' -Dichloro-3,3' -dinitro-2,2' -biphenyldiol no)quinazolines 115, 118 (menichlopholan, Bilevonlll>, Bayer 18 2,4-Diamino-6-[(3,4-dichlorobenzyl)ami• 9015) 278 no)quinazoline (PAM-l,392) 110 20 Dichloroisoproterenol (DCI) 28, 32, 224 18 2,4-Diamino-6-[(3,4-dichlorobenzyl)nitros• 16 Dichloromethotrexate 93 amino)quinazoline acetate (CI-679) 151 17 Dichloromethotrexate 324 18 2,4-Diamino-6-(3,4-dichlorophenoxy)• 18 Dichloromethotrexate 23 quinazoline 121 18 Dichloromonoftuoromethane 374 18 Diaminodiphenyl sulfone (4,4'-sulfonyl• 17 2',5-Dichloro-4' -nitrosalicylanilide (niclos• dianiline, dapsone) 108, 155 amide, phenasal, Yomesanlll» 119, 138, 22 2,7-Diaminoftuorenone 274 139,148-154,296,297 18 2,4-Diamino-6-(heterocyclic)quinazo• 17 (e) (Anthiphenlll>, Dicestallll>, lines 119 Theniathanelil, Vermiplexlll» 121, 152, 155, 18 2,4-Diamino-6-(2-naphthylsulfonyl)quin- 295 azoline (WR-158,122) 130 20 - 447 22 Diamorphine 211 22 - 46 20 Diamoxlll> (acetazolamide) 417 17 DL-erythro-a-(3,4-Dichlorophenyl)-p-(t• 17 Diamphenethide (Coribanlll» 118, 137,286 butylamino)-propanol HCL (B.W. 22 Diamthazole hydrochloride 130 65-54) 25 22 Dianabollll> (methandienone) 6,68 18 1-(3,4-Dichlorophenyl)-3-(4-{3-[(diethyl• 17 Diarrhea 460 amino )methyl)-p-anisidino}-6-( triftuorome• 19 Diarrhoea 482,491,504,519,526,527,570 thyl)-2-pyrimidinyl)guanidine (FI-345) 150 19 Diarrhoea syndroms 528 18 1-(3,4-Dichlorophenyl)-3-{4-[( l-ethyl-3- 19 Diarrhoea therapy 527 piperidyl)amino )-6-methyl-2-pyrimidinyl}• 19 Diarrhoea treatment 532 guanidine (WR-81,844) 140 22 Diasterlll> (cortivazol) 75 17 2,4-Dichloro-6-phenylphenoxyethylamine 18 Diaveridine 108 HCl (DPEA, Lilly 32391) 19 22 Diazaditwistane 209 17 2,4-Dichloro-6-phenyl-phenoxyethyl-di• 18 (Valiumlil) 434 ethylamine HBr (Lilly 18947) 19 19 - 210,225,246,297,362,379 17 6,8-Dichloro-2-phenyl-a-(2-piperidyl)-4- 20 - 393,422 quinolinemethanol (SN-IO,275) 270 22 - 230,242,356 17 7,l1a-DichlorotetracycIine 217 16 N-Diazoacetyl-glycine amide 88 18 Dichlorotetraftuoroethane (cyroftuo• 17 5-Diazoimidazole-4-carboxamide 341 rane) 378 16 6-Diazo-5-oxo-L-norleucine (DON) 88 17 2,2-Dichlorovinyl methy14-phenylbutyl 17 6-Diazo-5-oxo-L-norleucine (DON) 323 phosphate 306 20 6-Diazo-5-oxo-L-norleucine (DON) 470 17 2,2-Dichlorovinylphosphates 306 20 232, 233, 244 17 Dichlorovos (see Dichlorvos) 307 20 Dibenamine 414 16 Dichlorvos (DDVP, Atgardlil, Tasklil, 20 (Noverillll» 394 Vaponalll» 158, 168 21 Dibenzodiazepine derivatives 442 17 - 128, 157, 161, 164, 167, 170, 175,307 17 Dibenzoxazepine derivatives 469 17 Dichlosale 148 21 Dibenzoxazepine derivatives 442 20 DicIofenac sodium (Voltarenlil) 401 19 Dibenzylamine 155 22 Diconallll> (cyclizine+) 189 17 3,4' -Dibromo-5-chlorothiosalicylanilide, 20 Dicoumarol (Dicumanlll» 404 acetate of (Bayer 4059, brotianide, 17 Dicrocoeliasis 132, 276 Dirianlil) 115, 136,284 17 Dicrocoelium dentriticum 276 17 N, N-Di-n-butyl-4-n-hexyloxy-l-naph- 17 Dicrodenlil (hetolin) 118 thamidine (bunamidine, Scolobanlil) 302 17 Dictycidelll> (cyanacethydrazide) 131 17 Di-n-butyltin dichloride 294 17 Dictyocauliasis 176 17 Di-n-butyltin oxide 293 20 Dictyocaulus 350 17 Dicestallil (dichlorophene) 121 17 Dictyocaulus filaria 176 21 Dichlofenthion 179 17 Dictyocaulus viviparus 176 22 Dichlorenlil (chlormethine) 63 20 Dicumanlil (dicoumarol) 404 20 Dichlorisoprenaline 225,411 17 24 Index Vol. 16-23 249

21 Dieldrin 181 17 Sa,7a-Dihydroxy-ll-oxo-tetranorprosta- 21 319 noic acid 433, 445, 452 17 5-( 4-{(2-(Diethylamino )ethyl]amino }-I• 21 Dihydroxyphenylacetic acid 414 naphthylazo)uracil (CI-407) 255 16 Dihydroxyphenylalanine 220 17 N -( 4-{(2-(Diethylamino )ethyl]amino }-I• 16 3,4-Dihydroxyphenylglycol 348 naphthyl)octanamide 257 22 Diiodohydroxyquine (Diodoquin®) 42 17 6-{(2-(Diethylamino )ethyl]amino }-1,2,3,4- 20 (Diodo- tetrahydro-12H-benzo[a]thioxanthen-12- quin®) 438 one 250 17 2,6-Diiodo-4-nitrophenol (disophenol, An• 17 2-DiethylaminoethyI2,2-diphenylvalerate cylol®, DNP, Disofen®) 131,162,171,177, HCI (SKF 525-A) 13 278,280 17 2-[2-(Diethylamino )ethyl]-5-methyl-2H• 16 Diisopropyl-fluorophosphate 219 [1]benzothiopyrano[4,3,2-cdJindazole 249 16 Diisopropyl-phosphofluoridate 343 16 Diethylcarbamazine (Banocide®, Carici• 16 Diisopropyl-phosphorofluoridate 356 de®, Ditrazin®, Loxuran®, Notezine®, 17 4,4'-Diisothiocyanatodiphenyl sul- Hetrazan®) 173 phone 301 17 - 127, 176, 178, 180, 181, 182, 183, 185 17 trans-I,4-Di[ (2-isothiocyanato )ethyl]cyclo• 18 - 142,179,201,260,275 hexane (R.P. 14015) 300 19 - 50, 151 16 Dilantin® (diphenylhydantoin, pheny- 20 - 455 toin) 123 22 - 48 20 Dilantin® (diphenylhydantoin) 387 21 1-(N,N-Diethylcarbamyl-methyl)-2,4-dini• 17 Dilantin® (diphenylhydantoin) 224 tropyrrole (ORF 1616) 352 18 361 17 Diethyldithiocarbamate 24, 496 20 Diloxanide fuorate (Furamide®) 438 17 O,O-Diethyl-3-methoxy-2-quinoxalinyl 17 Dimercaprol 244 phosphorothioate 307 20 Dimercaptol (BAL) 446 17 N,N-Diethyl-N' -(4-nitroso-I-naphthyl)- 20 Dimethindene (Fenostil®) 426 258 18 449 20 475 16 2,2-Dimethyladipic acid 237 21 Diethylstilbestrol 243,318 16 y-(Dimethylamino) -butyric acid 290 22 Diethylstilbestrol 72 17 7-Dimethylamino-6-demethyl-6-deoxyte• 23 Diethylstilbestrol 57 tracycline 220 17 I, I-Difluoro-2,2-dichloroethyl methyl 22 4-Dimethylamino-2,2-diphenylvaleric ether () 16 acid 191 18 Difluoroethane 391 17 5-(Dimethylamino )-2-nitrosophenol 260 20 404 16 7,12-Dimethylbenz[a]anthracene 17 Digoxin 47,306 (DMBA) 98 21 Digoxin 115, 116 16 2,2-Dimethylgluratic acid 237 17 Dihomo-y-linolenic acid 430 16 2,2-Dimethylheptane-I,7-dioic acid 237 20 Dihydralazine (Nepresol®) 205,409 17 O,O-Dimethyl-I-hydroxy-2,2,2-trichloro- 17 Dihydroaldrin 24 ethylphosphonate (Dipterex®; trichlor• 20 Dihydroergocornine 415 phon; metrifonate) 268 20 Dihydroergocristine 415 16 [8- 14C]-3,6-Dimethyloctanoic acid 239, 20 415 284,285 17 Dihydrofluorouracil 329 16 2,2-Dimethyloctanoic acid- J-14C 245 23 Dihydrofolate reductase 60 23 2,4-Dimethylpentane 127 22 Dihydrogesterone (Duphastone®) 74 21 16,16-Dimethyl-PGE, 372 22 2,3-Dihydro-IH-imidazo[I,2-b]pyra- 22 2,6-Dimethyl-4-phenylpiperidin-4-o1 177 zole 288 17 3,3-Dimethyl-l-phenyltriazene 368,369 22 Dihydro-isoquinolines 286 17 Dimethylsulfoxide (DMSO) 16 17 5,8-Dihydro-5,8-methano-I,4-naphtho- 21 Dimethylsulfoxide (DMSO) 186 quinonedialkanesulphonimides 309 16 5,6-Dimethyl-4,5,6,7-tetrahydro- 17 Dihydro-prostaglandin EI 446 pterine 284 17 Dihydroprostaglandin E, 452 17 N,N -Dimethyl-2-thiophenepropionami• 17 13, 14-Dihydroprostaglandin EI 441 dine 308 17 13, 14-Dihydroprostaglandin F2a 444 17 5-(3,3-Dimethyl-I-triazeno )-4- 22 Dihydrotachysterol 84 carboxamide 369 22 Dihydrothebainone 153 19 4-a-Dimethyl- 149 17 9a, lla-Dihydroxy-15-oxoprost-5-enoic 18 Diminazene (Berenil®) 320 acid 453 22 - 42 17 Sa,7a-Dihydroxy-II-oxo-tetranorprosta- 17 Dinactin 68 1,16-dioic acid 452 250 Index Vol. 16-23

17 4,4' -Dinitrocarbanilide 273 19 Diphtheria toxoids 274 16 Dinitrochlorobenzene (DNCB) 88 19 Diphtheria vaccines 229 17 Dinitrofluorobenzene 70 17 Diphyllobothriasis 148 17 Dinitrophenol 65 17 Diphyllobothrium latum 148,292 17 a-Dinor-prostanoic acid 420 18 Diphyllobothrium larum 198 22 N,N-Dioctadecyl-N',N'-bis(2-hydroxy• 20 Diphyllobothrium latum 447 ethyl)-propanediamine 275 22 Dipipanone 189 20 Diodoquin® (diiodohydroxyquine, diiodo• 20 88 hydroxyquinoline) 438 22 Diprenorphine 156 22 Diodoquin® (diiodohydroxyquine, diiodo- 17 Dipterex® (metrifonate, trichlorfon) 268 hydroxyquinoline) 42 22 Dipterex® (metrifonate, trichlorfon) 47 16 Dioleylgiyceryl-3-phosphoryicholine 248 17 Dipylidiasis 149,293 20 1,3- derivatives 109 17 Dipylidium caninum 300 16 Dipeptidyl-Transferase 404 17 Dipyridamole (Persantin®) 74 18 Dipetalonema perstans 201,260 20 - 406 18 Dipetalonema witei 261 17 a,a'-Dipyridyl 496 20 Diphemanil (Prantal®) 420 17 Dirian® (3,4' -dibromo-5-chlorothiosali• 20 Diphenhydramine (Benadryl®) 424 cylanilide acetate, Bayer 4059 brotia• 20 Diphenhydramine derivatives 220 nide) liS, 136,284 20 Diphenhydramine derivatives 108 18 Dirofilaria immitis 143,261 16 p-Diphenol-Oxidase 390 19 Dirofilaria immitis 128 22 (Lomotil®) 195 17 Dirofilariasis 181 22 1,2-Diphenylethylpiperazines 206 20 Diseases, international classification 492 16 Diphenylhydantoin (, Dilan- 16 Diskelektrophorese 366 tin®) 123,213,223 20 Disodium cromoglycate (DSCG) 589 17 - 47,51 23 Disodium cromoglycate (DSCG) 42 18 - 456 17 Disofen® (disophenol) 131 20 - 387 17 Disophenol (2,6-diiodo-4-nitrophenol, An• 23 - 114 cylol®, DNP, Disofen) 131,162,171,177, 16 Diphenylhydramine 342 278,280 22 2,6-Diphenyl-3-methyl-2,3-dihydroimida- 21 112 zo-[2,I-b) 288 16 Dissoziation 367 17 4,7-Diphenyl-I,IO- 14 16 Dissoziationsmittel 366 22 3,3-Diphenylpropylamine derivatives 189 22 Distalgesic® (dextropropoxyphene) 189 20 (Hispril®) 424 16 Distoma haematobium 12 17 2,2-DiphenylvaJeric acid (SKF 2314) 18 20 Distomer 105 16 Diphetarsone (Amebarsin®, Bemarsal®, 17 N ,N-Disubstituted-N' -(5-nitro-2-thia- Rodameb®) 173 zolyl)oxamides 263 17 - 123,174 16 Disulfidbriicken 367 19 - 36 17 24, 26 20 - 453 16 Disulphiram 220, 349 16 Diphezyl (difesyl, difesil) 170 17 Dithiazanine (Anelmid®, Dizan®, Tel- 17 Diphezyl (difesyl, difesil) 130, 175 mid®) 127,170,171,175 19 Diphtheria 241, 256, 336, 347, 356, 412, 19 Dithiazine (Delvex®) 154 452 22 - 48 23 Diphtheria II, 17 17 Dithiocarbamic acid esters 288 19 Diphtheria, age incidence 425,452 17 Ditrazin® (diethylcarbamazine) 127 19 Diphtheria, age profile 412 20 208, 243, 415 19 Diphtheria, bacteriological studies 427 20 Diuril® (chlorothiazide) 417 19 Diphtheria, clinical type 426 17 Dizan® (dithiazanine) 127 19 Diphtheria, complications 428 16 DMBA (7,12-dimethylbenz[a)an- 19 Diphtheria, death 429 thracene) 98 19 Diphtheria, diagnosis 419,452 17 DMSO (dimethylsulfoxide) 16 19 Diphtheria, epidemiology 336 21 DMSO (dimethylsulfoxide) 186 19 Diphtheria, immunization 358, 4!4, 455 16 DNCB (dinitrochlorobenzene) 88 19 Diphtheria, mortality 423 20 Dogrnatil® () 391 19 Diphtheria, seasonal incidence 434, 452 20 Dolantin® (meperidine, ) 398 19 Diphtheria strains 241,428 22 Dolantin® (meperidine, 19 Diphtheria symptoms 426 pethidine) 168 19 Diphtheria toxin 283 22 Doloxene® (dextropropoxyphene) 189 19 Diphtheria toxin production 284 22 Domar® () 262 16 DON (6-diazo-5-oxo-L-norleucine) 88 Index Vol. 16-23 251

17 DON (6-diazo-5-oxo-L-norleucine) 323 20 Drug development 155, 160, 175, 182 20 DON (6-diazo-5-oxo-L-norleucine) 470 16 Drug discovery 198 16 Dopa 346 20 Drug discovery 160, 174, 184 16 L-Dopa 340,343,344,349 23 Drug discovery 51 20 L-Dopa 423 20 Drug efficacy 19 23 L-Dopa O-methyl ester 78 16 Drug efficacy study (DES) 200 16 336, 345 19 Drug introduction 182 17 Dopamine 491 22 Drug manufacturer 18 19 Dopamine 149 17 12 20 Dopamine 423 20 Drug metabolism 11, 477 21 Dopamine 410 23 Drug metabolism 100 21 Dopamine analogs 422 17 Drug metabolism inhibition 12, 18,21 16 Dopamine-p-hydroxylase 338, 345 17 Drug metabolism inhibitors 20 21 Dopamine receptors 410 21 Drug monitoring 237 21 Dopamine receptor 422 21 Drug monitoring centres 256 21 Dopamine 438 21 Drug monitoring characteristics 259 21 Dopamine synthesis 411 21 Drug monitoring concepts 240 16 Dopaminergic receptors 346 21 Drug monitoring systems 239,282 20 Dopram® (doxapram) 397 23 Drug partitioning 156 20 Doriden® () 387 20 Drug receptor 324 21 Dowtherm A ® 36 23 Drug receptor 99, 205 20 Doxapram (Dopram®) 397 20 Drug receptor interaction 128 20 (Sinequan®) 394 20 Drug receptor isolation 325 22 Doxorubicin (adriamycin) 67 23 Drug receptor 205 17 (Vibramycin®) 211, 212, 228, 20 Drug regulation 18 236 22 Drug-regulatory agency 19 22 - 53 20 Drug research, influences on 160 17 DPEA (Lilly 32391, 2,4-dichloro-6-phenyl- 16 Drug research 195 phenoxyethylamine HCl) 19 20 Drug research 10, 160, 182 17 DPH (diphenylhydantoin) 47,51 22 Drug retailer 19 18 Dracontiasis 202 16 Drug selection 198 20 Dracontiasis 548 20 Drug side effects 10 17 Dracunculiasis 178 20 Drug structures 14 18 Dracunculus medinensis 195 21 Drug terminology 273 20 Dracunculus medinensis 458 21 Drug therapy 233 23 Dreiding models 222 23 Drug transport 150 17 Drocarbil (Cetarsol®, Larumen®, Neumu- 23 Drug transport, kinetic models 161 ral®, Tenoban®) 121, 149, 154 16 Duanomycin 91 22 Drolban® ( propionate) 69 17 Duazomycin A 324 20 Droleptan® () 391 22 Duphastone® (dihydrogesterone) 74 22 Dromoran® (Ievorphanol) 166 22 Durabolin® (nandrolone phenylpro- 22 Droncit® () 49 pionate) 69 18 Droperidol (Droleptan®) 437 22 Durenat® (sulfamethoxydiazine) 31 20 - 391 22 (Duphaston®) 74 22 - 185 17 Dymanthine (Thelmesan®) 131, 151, 158, 22 (Drolban®) 69 162, 175 20 Drug abuse 22 19 - 103 22 Drug abuse 23 22 DymelorGP (acetohexamide) 81 17 Drug action 66 20 Dyrenium® () 417 21 Drug adverse reactions 233,237 19 Dysphagia 199,218 21 Drug adverse reactions, causality 274 21 Drug adverse reactions, data 239,276 E 21 Drug adverse reactions, evaluation 238 16 EAE (experimental allergic encephalomye- 21 Drug adverse reactions, mechanism 274 litis) 87 21 Drug adverse reactions, reports 264 20 Ecarazine 205 21 Drug adverse reactions, severity 274 18 Echenostoma ilocanum 196 21 Drug concentration 113, 127 20 Echinococcus 448 22 Drug consumer 21 17 Echinococcus granulosus 149,293,303,306 20 Drug delivery 160, 175 18 Echinococcus infection 193 21 Drug delivery systems 380 17 Echinococcus multilocularis 149,295,305 16 Drug development 196 20 Ecolid® (chlorisondamine chloride) 409 252 Index Vol. 16-23

22 109, 119 16 287,310,365 17 Ectoral® (ronnel) 128 17 Enzyme 19 20 Edecrin® (ethacrynic acid) 417 20 Enzyme 13 23 Egg-white 37 20 Enzyme induction 298 17 11, 14-Eicosadienoic acid 437 17 Enzyme inhibition 26 17 Eicosa-5,8, 11, 14, 17-pentaenoic acid 430 20 Enzyme inhibitors 13 17 5,8,11, 14-Eicosatetraenoic acid 433 23 Enzyme inhibitors 60 17 5-cis-8-cis-12-trans-l4-cis-Eicosatetraenoic 16 Enzyme, kiiltesensitive 367 acid 433 16 Enzyme,oligomere 366 17 Eicosa-8,1l,I4-trienoic acid 431,434 17 Enterobiasis 171 17 8-cis-12-trans-l4-cis-Eicosatrienoic 18 Enterobiasis 202 acid 433 19 Enterobiasis 21 16 Eiweiss, gruppenspezifisches 374 20 Enterobiasis 452 20 Elavil® (amitriptyline) 394 20 Eosinophiles 576 16 Electrical stirn ulation 214 19 521 22 Electroencephalogram 358 20 Ephedrine 418,419 19 Electrolyte loss 530 22 Epidemiological pharmacology 11 23 Electronic parameters 206 16 Epilepsy 212 17 Electrophoresis 81 17 Epinephrine 46 16 Electroshock 349 20 Epinephrine 200 16 Elektrophoresemethoden 327 21 Epinephrine 420 18 Elephantiasis 178, 260, 270 22 Epipolythiodiketopiperazines 309 23 Elephantin 80 17 Epitetracycline 213 22 Elipten® (aminoglutethimide) 77 17 trans-( - )-14, 15-Epoxygeranylgeraniol 274 17 113, 133, 134, 150 16 cis-d,l-9, IO-Epoxyhexadecanoic acid 290 18 Emetine 86, 325, 355, 360 16 trans-d,l-9, IO-Epoxyoctadecanoic acid 290 20 Emetine 439,451 20 Equanil® () 392 17 17(-)-Emetine 24 23 Equilibrium concentrations 102 17 Emeto-Na® (antimony sodium tar- 22 sulfate 71 trate) III 22 Equimate® (fluprostenol) 84 20 Emivan® (etamivan) 397 20 Eraldin® () 411 16 Endocarditis 323 18 414 19 Endogenous pyrogen 403 21 Ergonovine maleate 374 22 p-Endorphin 199 22 Erimin® () 262 23 Endorphins 60 23 Erythema 30 16 Endotoxin 111,128 20 Erythroblastosis fetalis 584 19 Endotoxin 402,471 16 Erythrocruorin 382,432 19 Endotoxin fever 408 17 Erythrocyte 60 17 Endoxan® (cyclophosphamide) 305 17 meso-Erythrol 71 22 Endoxan® (cyclophosphamide) 64 16 313,318 19 Energy metabolism 151 21 Erythromycin 175 20 95,334 22 Erythromycin 58 22 Enkephalin 198 18 Erythromycin B 419 23 Enkephaline 60 22 Erythromycin estolate 58 16 Enolase 392,394 22 Erythromycin stearate 58 18 dispar 225 18 Erythronolide B 419 18 Entamoeba hartmanni 78 17 Erythronolide B boronyl esters 273 17 150, 263 20 Esbatal® (betanidine) 410 18 Entamoeba histolytica 78,225, 354 16 Escherichia coli 51 20 Entamoeba histolytica 438 18 Escherichia coli 22 18 Entamoeba polecki 78 19 Escherichia coli 460, 546, 574 16 Enterobius vermicularis 165 21 Escherichia coli 167 17 Enterobius vermicularis 172 23 Escherichia coli 61, 218 18 Enterobius vermicularis 191 23 Escherichia coli 218 19 Enterobius vermicularis 21,29,48 19 Escherichia coli infections 570 20 Enterobius vermicularis 452 16 Eserine 217 19 Enterotoxin 471,473 19 Eserine 149 23 Enterotoxin 13 22 (Eurodin®) 255 22 Entobex® () 42 20 475 20 Envacar® (guanoxane) 410 22 Estradiol 68 16 Enzymatic systems 344 22 71 Index Vol. 16-23 253

17 Estradiol-17P 24 22 Etrenol® (hycanthone) 47 22 71 17 Eubothrium crassum 293 20 Etamivan (Emivan®) 397 20 Eudismic affinity 105 17 Ethacrynic acid (Edecrin®) 66 . 20 Eudismic-aftinity correlations 136 20 Ethacrynic acid (Edecrin®) 212,417 20 Eudismic-aftinity quotient 105 18 Ethambutol (Myambutol®) 212 20 Eudismic index 105 22 - 36 20 Eudismic relations 133 17 16 22 Euglucon® (glibenclamide) 81 20 (Placidyl®) 387 23 Eupacunin 78 17 Ether 94 23 Euparotin 78 16 Ethidium® bromide (homidum bro- 23 Eupaserrin 78 mide) 99 23 Eupatocunin 78 22 - 38 23 Eupatorin 83 22 - 38 22 Eurodin® (estazolam) 255 20 (Valmid®) 387 22 Eusaprim® (sulfamethoxazole + thrimetho- 21 Ethinyloestradiol 300,318 prim) 33 22 71 20 Eutomer 105 18 Ethionamide (Trecator-SC®) 212 23 Exotoxin 13 22 Ethionamide (Trecator-SC®) 36 16 Experimental allergic encephalomyelitis 22 Ethisterone (Amenorone®) 73 (EAE) 87 17 p-Ethoxyacetanilide 490 22 Experimental pharmacology 11 17 2-EthylaminoethyI2,2-diphenylvalerate 21 Extrapyramidal syndrome 412 HBr (SKF 8742-A) 24 20 Eyes infection 361 16 Ethylbenzene 261 16 6-Ethyldecanoic acid 239 F 22 5-Ethyl-deoxyuridine 297 16 F-3OO66 (furapromidium; N-isopropyl-5- 17 Ethylenediaminetetraacetic acid 496 nitro-furanacrylamide) 60 19 Ethylenediaminetetraacetic acid 284 17 - 266 21 dimethane sulphonate (EDS) 351 20 Fabahistin® (mebhydroline) 426 17 Ethylene-l,2-dimethanesulphonate 274 19 Facial muscles 445 17 Ethylene glycol 71 19 Facial weakness 446 21 Ethylene glycol dimethyl ether 189 18 Falciparum malaria 155 22 (Maxibolin®, Orabolin®) 70 21 Family planning programs 296 16 3-Ethylheptanoic acid 238 20 Fanasil® (, sulformethox- 21 13-Ethyl-17-hydroxy-18,19-dinor-17d• ine) 436 pregn-4,9,II-trien-20-yn-3-one 22 - 31 (R2323) 308, 322, 350 17 Fasciola hapatica 134,270 17 Ethyl isocyanide 12 20 Fasciola hapatica 451 17 N-Ethylmaleimide 73 17 Fasciola gigantica 134, 277 21 N-Ethylmaleimide 183 17 Fascioliasis 133, 276 17 23,24 20 Fascioliasis 451 17 3-Ethyl-l-(5-nitro-2-thiazolyl)hydan• 17 Fasciolin® (hexachloroethane) 116 toin 262 17 Fasciolopsiasis 137 17 3-Ethyl-l-(5-nitro-2-thiazolyl)hydroura- 20 Fasciolopsiasis 451 cil 262 18 Fasciolopsis 194 16 2-Ethyloctadecanoic acid 236 17 Fasciolopsis buski 137,277 16 4-Ethyloctanoic acid 239 19 Fasciolopsis huski 137 16 2-[Ethyl-n-propylaminoJethyl-a,a-diphe- 20 Fasciolopsis huski 451 nylglycolate HCl) (BRL 1288) 342 22 Fasigyne® () 46 18 Ethyl stibamine (Neostibosan®) 310, 312 16 w-Fatty acid-oxygenase 246 20 - 442 16 Fatty acids 233,239 16 2-Ethyltetradecanoic acid 236 16 Fatty acids, a-substituted 236 20 Ethyl urethan 387 16 Fatty acids, P-substituted 238 18 Ethynodiol diacetate (Femulen®) 449 16 FDA (Food and Drug Administration) 196 21 - 308 16 FDA Papers 208 22 - 74 16 FDC Reports 208 20 Etophamide 438,441 16 Federal Food, Drug and Cosmetic Act 20 88 (FDC Act) 207 22 Etorphine 156 16 Federal Register 208 17 Etreno!® (hycanthone) 116 16 Federal Regulations 207 254 Index Vol. 16-23

20 Federal Trade Commission (FTC) 161 22 - 36, 120, 132 17 Fe(II)-ethylenediaminetetraacetic acid- 22 Fludanaline (3-fluoro-D-alanine) 55 complex 490 17 Flufenamate 470 21 Female reproduction 297 17 75 22 Femulen® (ethynodiol diacetate) 74 17 Flukanide@ (rafoxanide) 115,282 17 Fenchlorphos (ronnel) 128 21 Flumequine 34 20 Fenetylline (Captagon®) 396 22 Flumethasone 17-trimethyl acetate (Loca- 20 (Ponderal®) 419 corten@) 74 22 - 363 22 (Rohypnol@) 262, 360 20 Fenostil® (dimethindene) 426 22 acetonide (Synalar@) 75 20 (Leptanal®, Sublimaze®) 398, 22 21-capronate (Ultralan@) 74 399 21 Fluoroacetamide 353 22 - 185,211 22 3-Fluoro-D-alanine (fludalanine) 55 16 Fenthion (Baytex®, Talodex®, Tigu- 17 5-Fluorocytosine (flucytosine) 331 von®) 168 22 5-Fluorocytosine (flucytosine) 444 17 - 128, 167, 182 16 5-Fluorodeoxyuridine 123 16 Fermentation 272 17 1-Fluoro-2,4-dinitrobenzene 73 17 Fermentation 229 17 5-Fluoroorotic acid 332 23 Fermentation broths 55 18 Fluoropipamide 437 23 Fermentation programs 55 17 5-Fluoropyrimidin-2(1H)-one 332 16 Ferredoxin 430 17 5-Fluoropyrimidin-4( IH)-one 332 19 Ferric ammonium citrate 546 21 Fluorouracil 174, 199 17 Fertility control 458 22 Fluorouracil 64,297 23 Fertility control 56 16 5-Fluorouracil 96, 123 17 Fertility, male 459 17 5-Fluorouracil 329 16 Fettsliure-Synthetase-Komp1ex 420 20 5-Fluorouracil 469 19 Fever pathogenesis 402 17 5-Fluorouridine 329 18 FI-345 (1-(3,4-dichlorcphenyl)-3-(4-{3- 17 5-Fluorouridylic acid 329 [( diethylamino )methyl]-p-anisidino )-6-( tri• 21 a-Flupenthixol 417 fluoromethyl)-2-pyrimidinyl)guani- 18 (Prolixin@) 455 dine) 150 20 - 389 16 Fibrinogen 380 21 - 416,417 16 Fibroin 380 22 Fluprednylidene acetate (Decoderm@) 75 17 Fibrosis 39 21 Fluprostenol (Equimate@) 326 19 Filaria brugia 58 22 - 84 18 Filaria control 270 22 (Daimane@) 261,361 18 Filarial infection 178 20 (Imap®) 391 19 Filarial infection, immunodiagnosis 128 16 Folic acid 93 17 Filariasis 180 17 Folic acid 324 18 Filariasis 45,174,201,260,270,284 18 Folic acid 107 19 Filariasis 128 19 Folic acid 108 20 Filariasis 455 20 Folic acid 471 18 Filariasis, control of 179, 188,265 22 Folic acid 86 18 Filariasis, distribution of 174 17 Folic acid antagonists 324 17 Filipin 67 16 Folinic acid 93 18 Filipin 418 16 Follikelstimulierendes Hormon 374 22 Filipin 95 16 Food and Drug Administration (FDA) 196 19 Filter membranes 467 20 Food and Drug Administration (FDA) 18, 17 Flagyl® () 125 161, 164, 187, 193 20 Flagyl@ (metronidazole) 438,439 21 Food and Drug Administration (FDA) 304 22 Flagyl@ (metronidazole) 46 22 29 19 Flaxedil@ (gallamine) 296 22 Formo-Cibazol@ (formosulfathiazole) 31 20 Flaxedil@ (gallamine) 422 22 Formosulfathiazole (Formo-Cibazol@) 31 22 Fletazepam 249 17 Formycin B 343 22 Filixic acid 46 16 Formyl-Tetrahydrofolat-Synthetase 408 22 Florenal 303 20 Fortral® () 398, 399 22 Floxymesterone (Halotestin@, Ultan• 22 Fortral@ (pentazocjne) 160 dren@) 69 22 367 18 437 23 Fosfomycin 54 20 Flucytosine (5-Fluorocytosine, Anco• 17 Frantin® (bephenium pamoate) 158 bon@) 444 23 Free-Wilson analysis 202 Index Vol. 16-23 255

23 Free-Wilson model 101,202 22 Gentamycin (Garamycin®) 56 23 - 202 16 Gentisic acid 98 17 Freon BU 277 22 Geopen® (carbenicillin) 51 17 Freon 112 277 16 Geranic acid 242 23 Fructose 28 16 Gerinnungsfaktor VIII 432 16 Fruktose-Diphosphatase 396, 398 16 Gerinnungsfaktor XIII 430 17 Fuadin® (stibophen) 112 17 Germanin® (suramin sodium) 132 22 Fuadin® (stibophen) 47 22 Germanin® (suramin sodium) 38 21 Fucidin 175 22 Gestafortin® () 74 22 Fulvicin® (griseofulvin) 55 19 Giardia lamblia 81 16 Fumarase 404 20 Giardia lamblia 441 22 Fungizone® (amphotericin B) 59 20 441 20 Furacin® (nitrofural, ) 446 18 Gibberella/ujikuroi 323 22 Furacin® (nitrofural, nitrofurazone) 33 17 Gibbs-Donnan equilibrium 62 22 Furadantin® (nitrofurantoin) 33 22 Glibenclamide (Daonil®, Euglucon®) 81 22 Furaltadone (Altafur®) 45 22 Gli1lumide 80 20 Furarnide® (diloxanide fuorate) 438 22 Gliotoxin 309 16 Furapromidium (F-30066; N-isopropyl-5- 22 (Pro Diaban®) 80 nitro-2-furanacrylarnide) 60 22 Glitisol® (thiamphenicol) 54 17 - 266 22 Globucid® (sulfaethidole) 34 21 Furo[2,3-b)pyridines 91 16 a 2-Globulin 108 17 (Lasix®) 67 16 )I-Globulin (immunoglobulin G) 378 20 - 210,417 20 Glomerulonephritis 584 20 240 20 Glucagon receptor 340 20 Fusarium oxysporum 241 23 a-l,6-Glucan 29 16 Fusidic acid 314,318 20 Glucanthine® (N-methylglucamine anti- 22 Fusidic acid 59 moniate) 442 16 Glucokinase 436 G 22 Glucophage® () 80 17 G-61O (4-chloro-a,a'-bis(5-chloro-2- 22 o-Glucosamine 307 hydroxyphenyl)-2,6-xylenol) 295 17 Glucose 70 23 Galactose 33,41 23 Glucose 28,41 23 o-Galactose 40 20 Glucose infusion 553 20 p-Galactosidase 328 17 Glucose metabolism 62 16 Galaktose-l-Phosphat-Uridyl-Trans- 20 Glucose metabolism 537 ferase 392 16 Glucose-6-phosphat-Dehydrogenase 410, 16 p-Galaktosidase 416,442 438 20 Gallamine (Flaxedil®) 422 20 Glucose transport permease 329 23 Gambogic acid 71 23 o-Glucose 40 16 Ganglia, basal 335 17 Glucuronic acid 488, 497 20 Ganglionic blockers 200 20 Glucuronic acid 563 22 Gantanol® (sulfamethoxazole) 31 20 a-Glucuronic acid lactone 563 22 Gantrisin® (sulfisoxazole) 31 18 Glucuronidase 18 22 Garamycin® (gentamycin) 56 16 p-Glucuronidase 440 18 Gaschromatography 439 20 p-Glucuronidase 559 17 Gastric acid secretion, inhibitors of 460 16 Glutamat-Decarboxylase 412 17 Gastroenteritis 164 16 Glutamat-Dehydrogenase 414 19 Gastroenteritis 490,519,572,578,586 16 Glutamat-Mutase 402 19 Gastroenteritis, clinical evaluation 492 16 Glutamic acid 221 19 Gastroenteritis, diagnosis 594 16 Glutamic acid hydrazide 223 19 Gastroenteritis, epidemiology 494,573 16 Glutamin-Aminotransferase 436 19 Gastroenteritis, features 574 17 Glutamine antagonists 323 19 Gastroenteritis, incidence 573,595 16 Glutaminphosphoribosyl-pyrophosphat- 19 Gastroenteritis, investigations 572 Aminotransferase 406 19 Gastroenteritis, treatment 576 16 Glutamin-Synthetase 416 16 Gehirnprotein 374 22 Glutamyl guanidine 308 17 Gel filtration 81 22 Glutaraldehyde 130 18 Gentamicin C I 423 16 Glutathion-Peroxidase 392 18 Gentamicin CIa 423 16 Glutathion-Reductase 398 18 Gentamicin C2 423 17 Glutethimide (Doriden®) 25 256 Index Vol. 16-23

20 Glutethimide (DoridenGl ) 387 17 Guaneran 341 22 - 366 20 (Ismelin4!» 214,410 23 DL-Glyceraldehyde 40 21 - 357 16 d-Glycerat-Dehydrogenase 390 16 Guanidin 366 16 Glycerinaldehyd-3-phosphat-Dehydroge- 22 79, 299 nase 400, 436 16 Guanidinoacetat-Kinase 394 16 Glycerin-Dehydrase 406 20 (Vatensol4!» 215,410 16 Glycerin-Kinase 408 20 Guanoctine 240 16 Glycerin-3-phosphat-Dehydrogenase 390, 20 Guanosine 3',5'-monophosphate (cyclic 434 GMP) 329 17 71 20 Guanoxane (Envacar4!» 215,410 17 Glycero-phospholipid 77 20 Guanylate cyclase 329 16 Glycinase 328 18 cis, trans, cis-tetrakis-(4-Guanylphenyl) 20 Glycine receptors 341 cyclobutane 317 16 Glycinin 432 16 Gurkenmosaik-Virus 382 16 Glycobiarsol (BroxolinGl , MilibisGl , 21 Guthion 190 ViaseptGl) 173 16 GVH (Graft-versus-host) 89 17 - 123, 174 16 Glycogen-Phosphorylase 440 H 16 Glycolic acid 277 16 HA-966 (l-hydroxy-3-amino-pyrrolid- 16 Glycolipids 264 one-2) 348 17 Glycolipids 72 22 107 16 3-Glycoloyl-6-methyl-2,3-dihydropyran- 19 Haemagglutination Test 77,123,131,268 2,4-dione 261 17 Haemoglobin 62, 92 17 Glycolysis 66 17 Haemolysis 75,92 16 Glycopeptide 327 17 Haemolysis, reversibility 94 20 Glycoprotein 328 16 Haemonchus contortus 161, 163 23 Glycoprotein extract 15 17 Haemonchus contortus 164 16 a 2-Glycoprotein 105 20 Haemonchus contortus 350 16 Glycosylation 297 18 Haemorrhage 81 16 Glycyl-tRNA-Synthetase 408 22 Haldrone4!> ( acetate) 75 16 Glykogen-Phosphorylase A 414 22 Haliconllll () 254,255 16 Glykogen-Phosphorylase B 414 16 Hallucinogenic action 224 16 Glykogen-Synthetase 414 16 (Serenace4!» 342,346 16 Glykolsiiure-Oxidase 412 17 - 25 16 Glykoprotein 374 18 - 437 20 Glycopyrrolate (Robinul®) 420 20 - 390 22 Glymidine (Redul®) 81 21 - 414 16 Glyoxylat-Carboligase 408 22 Haloprogin (Halotex®) 29, 127 16 Glyoxylsiiure-Reductase 394 22 Halotestinllll (floxymesterone) 69 22 Glyprothiazol 80 22 Halotex4!> (haloprogin) 29 20 cyclic-GMP (guanosine 3',5'-mono- 17 (1,1, I-trifluoro-2-chloro-2-bro• phosphate) 329,580 moethane) 16,76 17 Gold chloride 70 16 Haloxon (Helmiron®, Loxon®) 158,168 23 Gonococcal vaccine 20 17 - 129,158,160,164,168,170, 19 Gonorrh(o)ea 281 173, 175 23 Gonorrhoea 20 16 Hiimagglutinin 376,380,382 16 Graft-versus-host (GVH) 89 16 Hiimerythrin 376 17 Gramicidin 67 23 Hammett constant 101,206 17 Gramicidin S 68 16 Hiimocyanin 382,432 22 Griseofulvin (Fulvicin4!» 55, 122 16 Hiimoglobin 382,376,432 18 Griseofulvins 415 16 Hiimoproteide 367 20 Guaiphenesin (Resyl®) 392 22 Hamycin 106 19 Growth 267 23 Hansch model 101 22 Growth hormone 360 18 Hansolar® (acedapson), 4',4"'-sulfonyl- 19 Growth test 467 bisacetanilide) 108, 156 20 216 16 Haptoglobin 1-1 376 20 Guanacline 215 16 353 20 Guancydine 216,240 16 353 20 216 20 Harmonyl® (deserpidine) 408 Index Vol. 16-23 257

16 Hamstoff 366 17 2,3,4,4a,5,6-Hexahydro-IH-pyrazino• 16 Health, Education and Welfare [1,2-a]quinolines 254 (HEW) 207 23 2,3,4,4a,5,6-Hexahydro-IH-pyrazino• 20 Health statistics 499 [1,2-a]quinolines 217 20 Heart diseases 506 16 chloride (Vegoly- 17 Heart diseases, hypertensive 39 sen®) 219 17 Heart diseases, rheumatic 39 20 - 200,409 17 Heart muscle 39 17 Hexamethylmelamine 362 16 Hefe-Enolase 370 20 Hexamethylmelamine 476 16 Hefe-Hexokinase 370 17 Hexamethylphosphoramide 274 16 Hefe-Phosphofruktokinase 370 22 Hexetidine 130 22 Helenine 272 17 23,490 17 Helmatac® (perbendazole) 159 16 Hexokinase 396 22 Helmatac® (perbendazole) 49 16 Hexosaminidase 328 17 Helmetina® (phenothiazine) 131 22 Hexosan® (hexachlorophene) 29 19 Helminthiasis 11,48 16 n-Hexylphenylketone 262 19 Helminthiasis, chemotherapy of 158, 162 19 Hexylresorcinol (Caprokol®) 36 19 Helminthiasis, intestinal 158 22 - 46 19 Helminth infections 119, 155, 160 16 Hildebrandt acid 242 19 Helminth physiology 147 17 Hilomid 114, 135, 139,282 17 Helmiron® (haloxon) 129 16 Hippocampus 212 18 Hemagglutinin 255 16 Hippuric acid 260,261 17 Hemoglobin 492 22 pHisohex® (hexachlorophene) 29 17 Hepadist® (hexachlorophene) 114 20 Hispril® (diphenylpyraline) 424 23 Heparin 43 20 414 19 281 23 Histamine 31,39,43 17 Heptachlor epoxide 24 16 Histidin-Ammonium-Lyase 406 16 Heptane-l,7-dioic acid 235 16 Histidin-Decarboxylase 404 19 Herd immunity 252 16 Histidinol-Dehydrogenase 392 22 151 16 Histidinolphosphat 388 17 Heterophyiasis 138 17 HN2 ( mustard, mechloreth- 18 Heterophyes heterophyes 196 amine) 349 17 Hetol® (hexachloroparaxylol) 117,270 17 nor-HN2 353 20 Hetol® (hexachloroparaxylol) 450 20 420 17 Hetolin (l-methyl-4-[3,3,3-tris(p-chloro• 16 Homidium bromide (Ethidium®) 99 phenyl)propionyl]piperazine hydrochlo• 22 - 38 ride, Dicroden®) 118, 133, 287 22 Homobenzomorphans 165 17 Hetrazan® (diethylcarbamazine) 127 22 4-Homo-isotwistane 279 20 Hetrazan® (diethylcarbamazine) 455 17 Homomycin 302 22 Hetrazan® (diethylcarbamazine) 48 17 w-Homo-prostanoic acid 420 16 HEW (Health, Education and Wel- 16 Homoserin-Dehydrogenase 400 fare) 207 16 336 18 1,2,3,4,5,6-Hexachlorocyclohexane 21 Homovanillic acid 414 (BHC) 248, 267 17 Hookworm 160 17 Hexachloroethane (carbon hexachloride, 18 Hookworm 45, 280 Fasciolin®) 116, 132, 136, 139, 277 19 Hookworm 40,81 17 3,3',5,5', 6,6'-Hexachloro-2'-hydroxysali• 20 Hookworm 355 cylanilide 283 19 Hookworm anaemia 108 17 Hexachloroparaxylol (a,a,a,a',a',a'-hexa• 19 Hookworm disease 6,36,44,81,86 chloro-p-xylene, Bitriben®, Chloxyle®, 19 Hookworm infection 2, 17,23,64,70,90, Hetol®) 117, 132, 133, 136-138,270,277 99, 108, 170 20 - 450 20 Hookworm infection 453 17 Hexachlorophene (hexachlorophane, Bile• 20 475 von®, Hepadist®, Hexosan®, pHiso- 23 Hormones 51 hex®) 114,135,153,278,295 21 Hospital monitoring 245 22 - 29, 128 16 HSA (human serum albumin) 108 16 Hexadecanoic acid 244 16 Hiillprotein 376 16 [lo-'4]-cis-Hexadec-9-enoic acid 288 21 Human chorionic gonadotrophin 359 16 2,4-Hexadienoic acid 240 21 Human chorionic sommatomammotro- 16 2,4-Hexadienoic acid amide 241,246 phin 365 16 2,4-Hexadienoic acid methylamide 241 16 Human serum albumin (HSA) 108 258 Index Vol. 16-23

17 Humatin® () 122 17 7a-Hydroxy-5,II-dioxo-tetranor-prosta• 20 Humatin® (paromomycin) 447 noic acid 452 16 Humoral immunity 73 21 6-Hydroxydopamine 412 22 Hyalodendrin A 310 17 II-Hydroxy-12-trans,l4-cis-eicosadienoic 21 Hyaluronidase 366 acid 437 16 Hycanthone (Etrenol®) 32,33,35,36,37, 17 II-Hydroxy-8, 12, 14-eicosatrienoic 47,49 acid 439 17 - 116,142,144,147,245,246 17 15-Hydroxy-8, 11, 13-eicosatrienoic 18 - 16 acid 435, 439 20 - 448 17 4-[(2-Hydroxyethyl)amino ]-2-(5-nitro-2- 22 - 47 thienyl)quinazoline 308 18 Hycanthone, clinical results 19 17 N-(2-Hydroxyethyl)-N'-(3-hydroxy• 16 Hycanthone acid 32 propyl)ethylenediamine 352 16 Hycanthone aldehyde 32,35 17 12-H ydroxy-8-trans, lO-trans-heptadeca• 16 Hycanthone methanesulfonate 49 dienoic acid 439 16 Hycanthone sulfoxide 36 16 d-2-Hydroxyhexadecanoic acid, biosynthe- 22 Hydantoin derivatives 287 sis of 280 19 Hydatid disease 75 16 5-Hydroxyindolacetic acid 340 20 Hydatid disease 448 16 Hydroxyindol-O-Methyltransferase 390 20 Hydergin® 415 17 4-(2-Hydroxy-3-isopropylaminopropoxy)- 20 Hydracarbazine 409 acetanilide (l.e.1. 50172) 53 17 Hydracrylic acid 353 17 Hydroxylase 14 20 Hydralazine (Apresoline®) 203, 204, 205, 17 Hydroxylation, aromatic 12 408 17 Hydroxylation, enzymatic 490 16 a-Hydrazinohistidine 99 16 w-l-Hydroxylation 246 18 Hydrocele 260,270 16 5-Hydroxylysine 296 20 210 17 5-[( 4-Hydroxy-3-methoxy)benzylidene ]-2- 17 Hydrocortisone 24, 25 imino-l-methyl-4-imidazolidinone 291 16 Hydrogenase 388,434 20 I4-Hydroxymorphine derivatives 56 17 15-Hydroperoxy-8, II, 13-eicosatrienoic 16 1-6-Hydroxynicotin-Oxidase 394 acid 435 20 I4-Hydroxynorrnophinone 57 23 Hydrophilicity 136 16 2-Hydroxyoctadecanoic acid 281,289 23 Hydrophobic interaction 99 16 [12, 13-3H]-9-d-Hydroxyoctadecanoic 23 Hydrophobic parameters 205 acid 289 17 o-Hydroxyacetanilide 497 17 o-Hydroxy-phenylacetic acid 493 17 p-Hydroxyacetanilide 490,497 17 o-Hydroxy-phenyllactic acid 493 16 w-Hydroxyacetophenone 261 17 o-Hydroxy-phenylpyruvic acid 493 16 Hydroxy acid dehydrogenase 245,247 17 5-Hydroxypicolinaldehyde thiosemicarba• 17 N-Hydroxyadenine 346 zones 347 16 I-Hydroxy-3-amino-pyrrolidone-2 (HA- 17 17-Hydroxyprogesterone 499 966) 348 22 Hydroxyprogesterone caproate (Delalu- 18 IIP-Hydroxy- 430 tin®) 73 22 14-Hydroxyazidomorphine 156 17 Hydroxyproline 491 16 y-Hydroxybutyric acid 348 16 l-trans-4-Hydroxyproline 296 21 y-Hydroxybutyric acid 411 17 15-Hydroxy-prostaglandin dehydroge- 17 3-Hydroxycoumarin 494 nase 447 17 4-Hydroxycoumarin 494 17 19-Hydroxyprostaglandin AI 450,451 17 5-Hydroxycoumarin 495 17 20-Hydroxyprostaglandin AI 450 17 6-Hydroxycoumarin 494 17 19-Hydroxyprostaglandin BI 451 17 7-Hydroxycoumarin (umbelliferone) 494 17 19-Hydroxyprostaglandin B2 451 17 8-Hydroxycoumarin 494 17 I5-Hydroxyprostaglandin dehydrogenase 17 N-Hydroxycyc1ophosphamide 358 substrate, specificity of 448 17 4-Hydroxycyclophosphamid 357 23 4-Hydroxyquinoline-3-carboxylates 139 20 4-Hydroxycyclophosphamid 468 17 Hydroxystilbamidine 377 17 3-D-Hydroxydecanoic acid 437 18 Hydroxystilbamidine 319 16 IO-Hydroxydecanoic acid 306 22 Hydroxystilbamidine 125 16 p-H ydroxydecanoyl-Thioester-Dehy• 16 2-Hydroxy tetracosanoic acid 282 drase 434 17 5-Hydroxytetracycline 217,227 17 7a-Hydroxy-5,II-dioxo-tetranor-prosta- 22 4' -Hydroxy-5,6, 7,8-tetramethoxyfla• 1, 16-dioic acid 452 vone 304 Index Vol. 16-23 259

16 Hydroxytryptamin (5-HT, ) 221, 20 Ildamen® (oxyfedrin) 406 336,341 17 Ileum 460 19 5-Hydroxytryptamin (5-HT, serotonin) 149 20 Illnes, prognosis of 495 20 5-Hydroxytryptamin (5-HT, serotonin) 426 20 Imap® (fiuspirilene) 391 23 5-Hydroxytryptamin (5-HT, serotonin) 31, 16 Imidazole 278 39,43 16 Imidazolylacetophosphat-Amino-Trans• 16 5-Hydroxy- 220,340 ferase 434 17 Hydroxyurea 348 16 2-Imino-5-nitrothiazolinylacetic acid 20 Hydroxyurea 473 derivatives 18 21 Hydroxyurea 199 17 Imipramin (Tofranil®) 25 20 Hydroxyzine (Atarax®) 392 20 - 394 20 Hygroton® (chlorthalidone) 417 22 - 365 17 Hymenolepiasis 150 16 Immune process 72 19 Hymenolepiasis 13,55 16 Immune reactions 73 17 Hymenolepis carioca 294,301 16 I=une system 70 17 Hymenolepis diminuta 298,302 23 Immunity indicators 17 18 Hymenolepis diminuta 198 19 Immunization 252,263,274,476 19 Hymenolepisfratema 55 20 Immunization 574 17 Hymenolepis nana 150,292,294 23 Immunization 10, 56 18 Hymenolepis nana 191 19 Immunization progress 276 19 Hymenolepis nana 13,81, 106 19 Immunization, response to 263 20 Hymenolepis nana 447 19 I=unization test 509 17 Hyostrongyliasis 163 20 I=unochemical research 574 17 Hyostrongylus rubidus 163 16 Immunogen 70 23 Hyperglycaemia 37 16 Immunogen reactive cells (IRC) 70 19 Hypersensitivity fever 407 19 Immunoglobulin 552 17 464 20 I=unoglobulin 577, 579 20 Hypertension 37, 198 16 Immunoglobulin A (IgA) 76 21 Hypertension 317 23 Immunoglobulin A (IgA) 17 20 552 16 Immunglobulin-A-Myelomprotein 378 20 Hypnotics 386 16 Immunoglobulin D (IgD) 76 19 Hypoalbuminaemia 110 16 Immunoglobulin E (IgE) 76 22 Hypochlorite 28, 29 20 Immunoglobulin E (IgE) 589 19 Hypoferremia 551 16 Immunoglobulin G (IgG) 74,76, 102 16 Hypoglycemia 341 23 Immunoglobulin G (IgG) 18 19 Hypoglycemia 530 16 Immunoglobulin M (IgM) 76, 382 23 Hypoglycemia 37 23 Immunoglobulin M (IgM) 18 19 Hypophysis 306 20 Immunoinfiammatory disease 583 16 Hypoprolinemia 343 19 Immunological mechanisms 155 18 Hypotension 394 19 Immunological research 282 19 Hypothalamus 306, 406 16 Immunologic tolerance 77 16 Hypothermia 342 20 Immunology 573 21 Hypovitaminosis 314 16 Immunosuppression 69,70,74,76 16 Hypoxanthin-Guanin-Phosphoribosyl• 16 Immunosuppression, biological tests 80 Transferase 434 16 Immunosuppressive activity 101 16 Immunosuppressive agents 71,82 I 20 I=unosuppressive agents 582, 583 20 Ibidomide 238 16 Immunosuppressive therapy 74, 78 20 Ibuprofen (Brufen®, Motrin®) 402 20 Immunosuppressive therapy 583 18 ICI-3,349 (1-(p-chlorophenyl)-3-(4-{[2-(di• 22 Imodium® 195 ethylamino )ethyl]amino }-6-methyl-2-pyri• 17 Imuran® (azathioprine) 341 midinyl)guanidine) 132 23 Inaba vaccine 14 17 I.C.I. 50172 [( 4-(2-hydroxy-3-isopropylami- 16 IND (Notice of Claimed Investigational nopropoxy)acetanilide)] 53 Exemption for a New Drug) 196 22 Idoxuridine (Stoxil®) 61 20 Indalitan® (clorindion) 404 17 Ifosfamide 359 20 Inderal® () 36, 411 16 IgA (Immunoglobulin type A) 76 20 Indocid® (indomethacin) 402 16 IgD (Immunoglobulin type D) 76 17 Indomethacine (Indocid®) 75,433,470 16 IgE (Immunoglobulin type E) 76 19 - 526 16 IgG (Immunoglobulin type G) 74,76, 102 20 - 402 16 IgM (Immunoglobulin type M) 76, 382 20 242,415 260 Index Vol. 16-23

20 Industrial drug research 16, 143 16 1-Isopentenyl adenosine 95 20 Infant mortality 500 20 Isophosphamide 480 18 Infection 278 20 (Isuprel®) 28,411,419 19 Infection immunity 475 22 Isoprinosine 297 18 Influenza 253,281 17 4-(2-Isopropylamino-I-hydroxyethyl)• 23 Influenza 13 methanesulfonanilide HCI (MJ 1999) 35, 19 Influenza vaccine 276 53 23 Influenza vaccine 18 17 2-[(lsopropylamino )methyl]-6-methyl-7- 18 Influenza virus 253 nitro-I,2,3,4-tetrahydroquinoline (UK 18 Influenza virus, Hong Kong strain 253 3883) 253 21 Inhibin 378 16 p-Isopropylmalat-Dehydrogenase 390 22 Inorganic complexes 304 16 Isopropylmalat-Synthetase 400 17 63 20 Isopropylmethoxarnine 28 20 Insect stings 589 17 N -Isopropyl-5-nitro-2-furanacrylamide 20 Insidon® () 394 (furapromidium, F-30066) 266 22 Insomnia 367 20 Isopropylphosphothionates 107 16 Insulin 374 17 Isoprostane 423 20 Insulin 327 17 Isoptin® () 46 22 Insulin 79, 82 20 Isoptin® (veraparni1) 406 23 Insulin 37,38 22 Isoquinazepon 250 20 Insulin receptor 327 17 I-Isoquinolinecarboxaldehyde thiosernicar- 20 Insulin receptor interaction 329 bazone 347 20 Intal® (cromolyn sodium) 427 20 Isospora belli 438 20 Intensain® (carbochromen) 407 20 Isospora hominis 438 22 Interferon 63,269 20 Isoterism II 23 Interferon 60 17 Isothiocyanates 287, 300 19 Intestinal antibodies 565 17 Isothiocyanatodiphenylamines 30 I 19 Intestinal malabsorptiol1 108 17 2-(4-Isothiocyanatophenyl) 21 Intrauterine devices 369 hydrochloride 272 22 Invenol® (carbutamide) 80 17 2-( 4-Isothiocyanatophenyl)-5-chlobenz• 20 Inversine® () 409 imidazole 288 16 Invertase 406 17 2-[2-( 4-Isothiocyanatophenyl)ethyl]-5- 23 Invert sugar 28 methoxybenzimidazole 288 18 Iodine 274 17 4-(3-Isothiocyanatophenyl)thiazole 288 20 Iodochlorohydroxyquin 439 17 2-( 4-Isothiocyanatostyryl)benzimid• 17 7-Iodo-6-demethyl-6-deoxytetracy- azole 288 cline 221 22 Isoxyl® (thiocarlide) 36 22 5-Iododeoxycytidine 296 20 Isuprel® (isoprenalin) 419 22 5-Iodo-2'-deoxyuridine 295 20 Ionizing radiation 533 J 17 permeability, passive 71 23 Jatrophone 83 17 Ion regulation 62 17 Jaundice 93 17 Ion selectivity 64 19 Jenner's vaccine 276 17 Ion transport 71 22 Jetrium® (dextromoramide) 189 17 25 17 Jonit® (bitoscanate) 131 16 (Marsilid®) 220 19 Jonit® (bitoscanate) 64,90,91 20 - 217,395 22 Jonit® (bitoscanate) 49 16 IRC (Immunogen reactive cells) 70 22 Irgasan DP300® () 29 K 19 Iron 283 22 Kafocin® (cephaloglycin) 53 19 Iron deficiency 110 20 Kala Azar (Visceral ) 442 20 Irradiation 486 21 Kanamycin (Kantrex®) 131,176 20 Ismelin® (guanethidine) 410 22 Kanamycin (Kantrex®) 56 18 Isobutane 382 22 Kantrex® (kanamycin) 56 16 Isocitrat-Lyase 406 16 Kartoffelvirus X 384 20 Isocyclorphan 60 16 Katalase 408 17 (Neoteben®, Rirnifon®) 26 22 Keflex® (cephalexin) 53 18 - 212 22 Keflin® (cephalothin) 53 22 - 34 22 Kefzol® (cefazolin) 53 16 Isonicotinic acid hydrazide 224 22 Kelfizina® () 31 17 Isonicotinic acid hydrazide 25 22 Kenacort® (triamcinolone) 75 Index Vol. 16-23 261

22 253 18 Leishmaniasis 290 20 Ketocyclazocine 82 19 Leishmaniasis 281 16 4-Ketocyclophosphamide 88 18 Leishmaniasis chemotherapy 301 17 4-Ketocyclophosphamide 354,356 20 Leponexs (clozapine) 391 16 2-Keto-3--phosphogluconat-Aldo- 18 Lepra cells 57 lase 390 19 Leprospirosis 281 16 Ketoglutarat-Dehydrogenasekilmplex 420 18 Leprosy 25,44,54,159,274 16 [l-14C]-2-Ketooctadecanoic acid 284 19 Leprosy 281,331 20 (OrudisS) 402 18 Leprosy epidemiology 25 17 15-Keto prostaglandin reductase 450 18 Leprosy neuropathology 54, 72 16 a-Ketosiiure-Reductase 434 18 Leprosy pathogenesis 58 16 p-Keto-Thiolase 404 20 Leptanals (fentanyl) 398, 399 20 KetrexS () 452 22 Leptanals (fentanyl) 185 20 Khellin 427 18 Leptospirosis 280 17 Klebsiella pneumoniae 275 16 Leucinaminopeptidase 370,410,414 19 Klebsiella pneumoniae 546 22 Leucine-enkephaline 198 16.Kohlensiiure-Anhydratase 404 23 Leuconostoc mesenteroides 30 16 Kreatin-Kinase 392 16 Leucyl-tRNA-Synthetase 436 16 a-Kristallin 382 20 Leukemia 584 22 Leukerans (chlorambucil) 63 L 18 Leurosidine 413 17 Labor, induction of 456 18 Leurosine 414 16 Lactat-Dehydrogenase 370,400 20 59,81 16 L-Lactat-Dehydrogenase 408 22 Levallorphan 166 16 Lactat-Oxidase 410 16 Levamisole (KetrexS, LevasolS) 162 17 62 17 - 156,178,181 20 Lactic acid 548 18 - 182,193,202 19 Lactoferrin 552 19 - 32,33 16 p-Lactoglobulin 374 20 - 347,349,357,452,588 16 Lactose-Repressor 430 22 - 48,49,288 16 y-Laevulinsiiure-Dehydratase 410 22 Levanxols () 242,261 18 Lagosin 418 22 Levasols (levamisol) 48 20 LampitS (Bayer 2502; ) 446 22 (DromoranS) 166 22 LampitS (Bayer 2502; nifurtimox) 45 23 - 117 22 LampitS (nifurtimox) 45 22 Lexotanils (bromazepam) 250, 262 22 Lamprenes (clofazimine) 38 20 Libriums (chlordiazepoxide) 393 18 Lankamycin 420 22 Libriums (chlordiazepoxide) 230,238 20 Largactils (chlorpromazine) 389 22 Lidaprims (sulfametrole + trimetho- 20 Laroxyls (amitriptyline) 394 prim) 31 17 Larumens (drocarbil) 121 17 (XylocaineS) 50,51,75 17 Larva migrans 184 20 - 403 18 Larva migrans 193 17 Lilly 18947 (2,4-dichloro-6-phenyl• 20 Larva migrans 455 phenoxyethyl-diethylamine HBr) 19 20 Lasixs (furosemide) 417 17 Lilly 32391 (DPEA, 2,4-dichloro-6-phenyl- 16 Learning 216,355 phenoxyethylamine Hel) 19 16 Learning test 357 22 Lincocins (lincomycin) 59 17 Lecithianase A 440 16 Lincomycin (LincocinS) 318 17 75, 78 22 - 59 ·17 Lecithin-cholesterol-acyl transferase 77 23' Lincomycin analogs 180 22 LedercortS (triamcinolone) 75 23 Linear free energy related model 204 22 LederkynS (sulfamethoxypyridazine) 31 17 Linoleic acids 433 21 Left ventricular ejection time (LVET) 107 20 Lioresals (baclofen) 423 21 Left ventricular injection time index 17 Lipids 76 (LVE-TI) 115 16 Lipoamid-Dehydrogenase 396 18 Leishmania braziliensis 291,293 23 Lipophilicity 98, 213 18 Leishmania chamaeleonis 298 23 Lipophilicity optimum 151 18 Leishmania donovani 293 23 Lipopolysaccharides 14 18 Leishmania enrietti 297 16 p-Lipoprotein 432 18 Leishmania mexicana 293 16 Lipoprotein, high-density 378 18 Leishmania tarentolae 298 17 Liposolubility 84 18 Leishmania tropica 291,292 16 a-Lipovitellin 380 262 Index Vol. 16-23

16 P-Lipovitellin 380 16 Lysostaphin resistance 325 21 Lippes Loop 329 16 Lysostaphin toxicology 327 19 Listeria monocytogenes 546 16 Lysozyme resistance 325 18 Litomosoides carinii 143,261 16 Lysyl-tRNA-Synthetase 438 19 Litomosoides carinii 128 16 Lytic activity 318 18 Liver abscess 85, 234 20 Liver abscess 440 M 16 Liver microsomes 253, 259 16 a 2-Macroglobulin 432 17 Liver cell 488 20 Macrophages 577 19 Loa loa 128 22 Madar® (desmethyldiazepam) 262 20 Loa loa 457 22 Madribon® (sulfadimethoxine) 31 20 Loaiasis 457 16 215 22 Locacorten® (flumethasone 17-trimethyl 19 Magnesium deficiency 531 acetate) 74 19 Magnesium sulphate 521 20 Local anaesthetics 403 16 Magnesium pemoline 348 23 Lochnericine 86 16 Major tranquilizers 91 19 Lockjaw 219 16 Makromolekille 365 16 Lombricin-Kinase 392 19 Malabsorption studies 110 17 Lombristop® (thiabendazole) 125 18 Malaria 47,101,184,246,283 22 Lomidine® () 45 19 Malaria 281 22 Lomotil® (diphenoxylate) 195 20 Malaria 435 22 Lomustine 64 18 Malaria control programme 246 20 Lopresor® () 411 18 Malaria eradication 246 22 Lorazepam (Ativan®) 242 20 437 23 Lorenz-Lorenz equation 207 16 Malat-Dehydrogenase 388,400,402,418, 22 Loridine® (cephaloridine) 53 434 22 Lotrimin® (clotrimazole) 36 23 Malate dehydrogenase inhibition 141 17 Loxon® (haloxon) 129 18 249 17 Loxuran® (diethylcarbamazine) 127 21 Male contraception 378 16 Lucanthone (Miracil D®, Nilodin®, Tixan- 21 Male reproduction 346 tone®) 24, 36 21 Malformations 242 17 - 115,141,144,147,245 19 Malic acid 286 18 - 16 20 Malignant tumours 508 19 - 154 19 Malnutrition 136,267 20 - 448 20 Management 184, 188 22 - 47 20 Mandelic acid nitrile glucuronide 566 16 Lucanthone, metabolism of 29,36 23 Mannan 30, 33, 40 16 Lucanthone sulfoxide 36 16 86 16 Luciferase 388,392,394 16 Mannomustine 86 20 Ludiomil® (maprotilin) 394 23 Mannose 30,41 20 Luminal® () 387 23 D-Mannose 40 18 Lung tuberculosis, chronic 217 18 Mansonia uniformis 179 17 Lungworm 178 18 Manzonella ozzardi 142,260 18 Lungworm 195 20 (Ludiomil®) 394 20 Luteinizing hormone (LH) 285 22 Marboran® (methisazone) 63 21 Luteinizing hormone (LH) 302 17 Maretin® (naphthalophos) 129 16 Luteinisierungshormon 374 20 Marezine® (cyclizine) 426 21 Luteolytic agents 325 21 Margulies spiral 329 20 Lymphocytes 577 16 Marihuana 224 23 Lymphocytes 38 22 Marijuana 365 16 Lymphoid atrophy 85 20 Marsilid® (iproniazid) 395 22 (Orgametril®) 74 16 Maskierung 367 16 Lysin-2,3-Aminomutase 412 19 Mass immunization 255,366 22 Lysodren® () 77 18 Mass spectrometry 400,401,408,439 17 Lysolecithin 78,81 20 Mast cells 576 20 Lysosomal cytolysis 551 23 Mast cells 43 20 Lysosomal 551 19 Mastomys natalensis 58 20 Lysosomal mechanisms 551 19 Mastomys unguiculatus 58 16 Lysostaphin 310,313,318 22 Maxibolin® (ethylestrenol) 70 16 Lysostaphin biosynthesis 310 23 Maytansine 87 16 Lysotaphin immunology 326 20 Mazindol (Sanorex®) 420 Index Vol. 16-23 263

19 M&B 938 (diamidino diphenylamine dihy- 17 Membrane permeability 84 drochloride) 259 17 Membrane potentials 64 16 MeA (3-Methylcholanthrene) 98 17 Membrane stabilization 75 18 Measles 28,241,281 17 Membrane structure 64,86 19 Measles vaccine 279,347 16 Memory 355 16 (Telminill>, Vermoxill» 159, 22 Menadione 86 160 17 Menichlopholan (Bayer 9015, Bilevon- 17 - 126, 170-172 Mill» 278,281 18 - 193,202 18 Meningitis 281 19 - 32,41,152,166 23 Meningitis 18 20 - 447,452 23 Meningococcal meningitis 13 22 - 49 19 Meningococcus meningitis 280 20 Mebhydroline (Fabahistinill» 426 20 Meningo-encephalitis 441 20 Mecamylamine (Inversineill» 202, 409 17 Mepacrine (quinacrine, Atebrinill» 294 17 Mechlorethamine (HN2, nitrogen mus- 22 - 38 tard) 349 20 Meperidine (pethidine, Dolantin®) 398 17 Medofenamate 470 22 - 168 22 (Nobriumill» 249,261 19 Mephenesin (Myanesin®) 290,297,362 20 Medical practice 493 20 - 392,422 20 Medical practitioners 195 19 Meprobamat (Equanilill» 210,225,289,297 20 Medicinal chemistry 16, 144 20 - 392 20 Medicinal drugs 17 23 39 20 Medicinal research 10, 182, 511 22 Merbromin (Mercurochromlll) 29 23 Medicinal research 52 22 Mercaptoalkylamines 276 16 Medrolill> () 103 19 2-Mercapto-ethanol 543 22 Medrolill> (methylprednisolone) 74 22 Mercaptopurine (Purinethollll) 64 21 320,348 16 6-Mercaptopurine 77,94, 103, 119 16 Medroxyprogesterone acetate 17 6-Mercaptopurine 336,339 (Proveraill» 92 20 6-Mercaptopurine 470, 473, 583 21 - 308 20 6-Mercaptopurine glucuronide 563 22 - 73 16 3-Mercaptopyruvatsulfurtransferase 388, 20 (Ponstanill» 401 434 20 Mefioquine (WR 142.490) 437 17 Mercuric chloride 70 22 Mefioquine (WR 142.490) 42 22 Mercuric chloride 129 22 Mefoxinill> (cefoxitin) 53 22 Mercurochrom (merbromin) 29 22 Megace® ( acetate) ;3 20 Mercurous chloride (calomel) 415 18 Megalomycin A 419 21 Mercury 124 21 (Megaceill» 305 22 Merfenill> 29 22 - 73 19 Meriones unguiculatus 58 20 Megimideill> (bemegride) 397 16 Meromyosin 378 18 308 17 Mesocestoides lineatus ISS 17 Melarsen® (melarsonyl , trime- 22 357,368 larsen, Mel Will» 123, 179, 182 22 (Pro-Vironlll) 69,70 17 Melarsonyl potassium (Mel Will» 123 21 299,348 20 - 446 22 Mestranol 71 20 Melarsoprol (Mel Bill>, Arsobalill» 445 20 Metabolic inhibitors 272 22-40 16 Metabolism 272 20 Mel Bill> (melarsoprol) 445 17 Metabolism 322 22 - 40 20 Metabolism 272 16 acetate (MGAiII» 92 17 Metabolism inhibitors 65 20 - 586 17 Metabolism (oxidative) of drugs 488 21 - 335 20 Metabolite antagonist 12 20 (Trausabunill» 394 20 Metabolites IS 20 Mellerilill> () 389 20 Metalol 32 17 Melphalan (Alkeranill» 349 22 Metandrenlll (17a-) 69 20 - 468 17 Metastrongylus apri 178 22 - 63 22 a- 160 20 Melsedinill> (methoqualone) 389 22 Metformin (Glucophagelll) 80 17 Mel Will> (melarsonyl potassium) 123 17 Methacycline (6-demethyl-6-deoxy-5- 20 - 446 hydroxy-6-methylene-tetracycline) 211, 20 Membrane drug receptor 323 212,228,236 19 Membrane filters 461,467 22 a-Methadol 193 264 Index Vol. 16-23

20 (Polamidon®) 398 20 a-Methyldopa (Aldomet®) 218,220,411 22 - 189 20 a-Methyldopamine 413 21 Methallibure 350 16 Methyl 11-eicosenoate 268 16 347 22 37 22 Methandienon (Dianabol®) 68 18 Methylene chloride 378 18 Methandrostenolone 453 22 3-Methylene oxindole 286 20 2,6-Methano-3-benzazocines 62 16 Methyl erucate 268 20 Methantelinium bromide (Banthine®) 420 23 p-Methyl escalutin 71 18 (Melsedin®) 461 21 2-Methyl-2-ethyl-4-phenyl-4-cyc1ohexene 20 - 389 carboxylic acid (ORF 3858) 322 18 Methasquin 116 22 3-Methylfentanyl 186 16 Methazolamide 220 16 5-Methyl-2-furanacrylamide 242 22 Methenamine (Urotropin®) 29 22 N-Methylfuryl-6.7-benzomorphans 164 22 Methenolone acetate (Primobolan®) 69 20 N-Methylglucamine antimoniate (Glucan- 16 Methici1lin (Celbenin®, Staphicillin®) 313, thine®) 442 314,317,323 16 N-Methylglutamat-Synthetase 414 22 - 50 17 Methylglyoxal bis(guanylhydrazone) 376 22 Methimidazole (Tapazole®) 77 17 7-Methylguanine 369 19 Methionine 468 16 Methyl heneicosate 270 23 L-Methionine S-adenosyltranferase 143 16 16-Methylheptdadecanoic acid 304 20 Methionine-enkephaline 398 16 15-Methylhexadecanoic acid 304 22 Methionine-enkephaline 198 16 Methyl2-hydroxyhexadecanoate 281 16 Methionyl-tRNA-Synthetase 394,404,434 16 Methyl12-hydroxy octadecanoate 270 22 Methisazone (Marborane®) 63 16 Methylmalonat-Semialdehyd-Dehydroge- 19 Methocarbamol 290,297 nase400 20 Methoserpidine (Decaserpyl®) 408 19 Methyl malonic acid 286 16 Methotrexate (Amethopterin®) 92, 103, 16 Methylmalonyl CO-A-Mutase 402 118 17 Methylmelamine 362 17 - 324 22 5-Methylmethadone 194 18 - 107 18 I-Methyl- 414 20 - 470,471,583 16 MethyI3-methylnon-2-enoate 243 22 - 64 16 MethyllO-methyloctadecanoate 270 18 Methotrimeprazine 455 20 N-Methylmorphian 398 20 28, 32 21 I-Methyl-5- 352 17 2-Methoxy-6-chloro-9-aminoacridine 295 19 N-Methyl-N' -nitro-N-nitrosoguani- 17 2-Methoxy-6-chloro-9-[(hydroxyethyl )ami- dine 466 no ]acridine 295 17 I-Methyl-I-nitrosourea 366 16 6-Methoxy-I,9-dimethyl-9H-pyrido[3,4- 16 3-Methylnonanoic acid 238 b ]indole 100 20 a-Methylnoradrenaline 413 17 Methoxyflurane (I, l-difluoro-2,2-dichlo- 20 a-Methylnorepinephrine 220 roethyl methyl ether 16, 76 16 Methyl 9-octadecanoate 274 17 d-3-Methoxy-N-methylmorphinan 23 22 a-Methyl-paratyrosine 368 17 1-3-Methoxy-N-methylmorphian 23 22 Methyl-patricin 132 17 6-Methoxy-4-(morpholinoamino )quinal- 16 14-Methylpentadecanoic acid 304 dine 271 18 (Ritalin®) 438 18 Methoxypromazine 433 20 - 397 22 Methscopolamine 368 23 114 22 N-Methyl-2-adamantyl-3' -spiropyrroli- 21 15-Methyl-17-phenyl-18,19,20-trinorpros• dine 278 taglandin Fa. 32 16 Methyl p-alkoxypropionates 272 16 Methylprednisolone (Medrol®, Urba- 16 Methylasparatat-Aminotranferase 396 son®) 103 17 2-Methyl-I,2-bis(3-pyridyl)-I-propanone 20 - 584 (, SU-4885) 15 22 - 74 16 3-Methylcholanthrene (MCA) 98,249,254 21 15-Methyl-prostaglandin Fa. 326,371 17 - 17,372,497 16 Methylscopolamine 342 20 Methylc10thiazide 210 22 9-Methylstreptimidone 311 16 p-Methylcrotonamide 241 17 6-(Methylsulfinyl)-8-oxopurine 340 21 Methyl-cyanoacrylate 345 17 6-(Methylsulfinyl)purine 340 21 p-Methyldigoxin 113 22 17a-Methyltestosterone (Metandren®) 69 16 6-Methyl-2,3-dihydropyran-2,4-dione-3- 17 5-(Methylthio )-2,4-dithiocyanatothio- carboxylic acid 261 phene 302 16 5-Methyldodecanoic acid 239 17 6-(Methylthio )-8-oxopurine 340 Index Vol. 16-23 265

17 6-(Methylthio )purine 338 17 Mintezol (thiabendazole) 125 17 6-(Methylthio)purine ribonucleoside 337 20 Mintezol (thiabendazole) 452 17 6-(Methylthio )purine ribonucletide 337 22 Mintezol (thiabendazole) 49 17 1-Methyl-4-[3,3,3-tris(p-chlorophenyl)pro• 17 Mintic® (methyridine) 123 pionyl)piperazine hydrochloride 118, 133, 16 Miracil A 24,25 287 16 Miracil A congeners 27 16 a-Methyl-m-tyramine 347 16 Miracil B 24,25,37 16 a-Methyltyrosine 220,357 16 Miracil C 24,25 16 a-Methyl-p- 337 16 Miracil D® (lucanthone) 24 16 3-Methylvaleric acid 284,285 17 Miracil D® (lucanthone) 115, 141, 144, 18 Methymycin 418 147,245 20 (Noludar®) 387 18 Miracil D® (lucanthone) 16 16 Methyridine (Dekelmin®, Mintic®, Pro- 19 Miracil D® (lucanthone) 154 mintic®) 158, 171 22 Miracil D® (lucanthone) 47 17 - 123, 159, 165, 169, 174, 176 16 Miracil D sulfone 31 19 - 150 16 Miracil D sulfoxide 31 22 - 49 16 Miracil X 31 21 Metioxate 33 16 Miracils schistosomicidal activity 26 20 210 16 Mirasan (N'-(3-chloro-p-tolyl)-N,N- 22 Metopirone® (metyrapone) 77 diethylethylenediamine) 52 20 Metoprolol (Lopresor®) 33, 229, 230, 411 17 - 250 16 Metrazol 219,349 16 Mirasan analogs 53,56 20 Metrifonate (Bilarcil®, Dipterex®) 448 17 Mithramycin 378 22 - 47 20 Mithramycin 474 17 Metronidazole (Clont®, Flagyl®, Tricha- 17 Mitomycin A 364 zol®) 125, 179 17 Mitomycin B 364 18 - 327,359,363 16 Mitomycin C 89 19 - 539 17 Mitomycin C 364 20 - 438,439 19 Mitomycin C 467 22 - 46 20 Mitomycin C 468 17 Metyrapone [SV-4885, 2-methyl-l ,2-bis(3- 22 Mitotane (Lysodren®) 77 pyridyl)-propanone, Metopirone®) 15,24 20 Mitotic inhibitors 473 22 - 77 17 MJ 1999 [4-(2-isopropylamino-l-hydroxy- 23 Mezereine 86 ethyl)methanesulfonanilide HCI) 35, 53 16 MGA® () 92 20 Mogadon® () 389,393 20 MGA® (melengestrol acetate) 586 22 Mogadon® (nitrazepam) 261 16 MIC (minimal inhibitory concentra- 23 Molar refractivity 135 tion) 313 23 Molar volume 135 17 Michaelis-Menton equation 19 23 Molecular connectivity 126, 209 22 Miconazole (Daktarin®) 36, 109, 114 23 Molecular connectivity index 126, 209 18 Microbacterium leprae 54 20 Molecular modification 11, 15, 145 16 Microbiological oxidation 57 23 Molecular orbital 209 16 Micrococcaceae 330 20 Molecular pharmacology 101 16 Micrococcus lysodeikticus 310,328 16 Mol-Gewichtsbestimmung 367 17 Microelectrode techniques 38 17 Moniezia benedeni 151 18 Microfilaria 270 17 Moniezia expansa 151,294 19 Micro filaria 148 17 Monieziasis 151 22 Microlut® () 74 22 3-Monoacetylmorphine 154 17 Microorganisms 228 22 6-Monoacetylmorphine 154 20 Midamor® (amiloride) 417 17 Monoamineoxidase inhibitors 24 22 Midicel® (sulfamethoxypyridazine) 31 20 Monoamineoxidase inhibitors 216 19 Milk supply 571 22 Monoamineoxidase inhibitors 364 19 Minimal agar plates 467 16 Monoamine-oxydase 336,344 16 Minimal inhibitory concentration 16 Monoamino-Oxidase 404,412 (MIC) 313 18 Monochlorodifluoroethane 381, 387 20 Migraine 38 18 Monochlorodifluoromethane 387 20 Migration inhibitory factor 585 20 Monocytes 577 17 Milibis® (glycobiarsol) 123 17 Monoiodoacetic acid 65 22 Minocin® (minocycline) 53 20 Monomycin 444 22 Minocycline (Minocin®) 53 , 17 Monomycin A® 122 20 234,415 17 Monopar® (stilbazium iodide) 124 266 Index Vol. 16-23

17 Monosaccharides 69 22 Nalidixic acid (Negram®, NegGram®, 16 L-trans-4-Monotritioproline 296 Nogram®) 34 21 Montanoa tomentosa 325 22 157 18 Moperone 437 20 56, 78, 93, 333 16 Morantel (Banminth II) 164 22 Naloxone 151 17 Morantel (Banminth II) 124, 160, 165, 172 23 Naloxone 117 17 Moranyl® (suramin sodium) 132 20 58,78,93 20 - 445 23 Naltrexone 117 20 Morbidity statistics 495 22 (Deca-Durabo• 23 204 lin®) 69 20 Morphinan derivatives 59 22 Nandrolone phenylpropionate (Durabo- 23 Morphinan derivatives 165, 166 lin®) 69 17 469 20 (Privine®) 220, 420 20 Morphine 82,333,398 23 Naphthalene 110 22 Morphine 151,211 16 Naphthalophos (Maretin®, Rametin®, 23 Morphine 116 phthalophos) 158, 168 18 Mosquitoes 181,270,283 17 - 129, 158, 168, 170 20 Motrin® (ibuprofen) 402 22 3-a-N aphthyl-5-diethylcarbamoyl-I,2,4- 22 71 oxadiazole 288 22 Mucidin 131 21 1,5-Naphthyridines 48 20 Mucous membranes, infection of 361 21 1,6-Naphthyridines 49 17 Muellerius capillaris 178 21 1,7-Naphthyridines 51 17 Multiceps multiceps 153 21 1,8-Naphthyridines 51 19 Mumps 280 20 Naprosyn® () 402 18 Murine tuberculosis 218 20 Naproxen (Naprosyn®) 402 19 Muscle relaxants 296 20 antagonists 46 20 Muscle relaxants 420 20 Narcotic antagonists agonist actious 46 19 Muscle rigidity 305 20 Narcotic antagonists chemistry 51 19 Muscle spasms 250 20 Narcotic antagonists clinical studies 89 22 Myambutol® (ethambutol) 36 20 Narcotic antagonists metabolism 75 20 Myanesin® (mephenesin) 392 20 Nardil® () 395 22 Mycifradin® () 56 16 NAS (National Academy of Sciences) 201 23 Mycobacterium arthritidis 47 16 Nasal flora 324 18 Mycobacterium leprae 27,54,57, 159 22 107 18 Mycobacterium tuberculosis 33, 155,215 16 National Academy of Sciences (NAS) 201 23 Mycobacterium tuberculosis 47 20 National Academy of Sciences (NAS) 171 22 Mycophenolic acid glucuronide 132 23 National Economic Development Office 17 Myleran® (busulfan) 365 (NEDO) 51 22 Myleran® (busulfan) 64 20 National Institutes of Health (NIH) 20, 17 Myleran analogs 366 164 18 Myocardial depression 393 19 National Nutrition Programmes 136 17 Myocardial infarction 39 16 National Research Council (NRC) 201 19 Myocarditis 416 20 National Research Council (NRC) 171 19 Myocardium 307 20 Natural products 144 22 Myolastan® () 250 23 Natural products analogs 53 17 Myometrium 454 18 Natural products metabolism 440 16 Myosin 380 23 Natural products research 51 20 Mysoline® () 387 20 Naturetin® (bendroflumethiazide) 417 19 Mytolon 296 20 Navidrex® (cyclopenthiazide) 417 17 Myxin 302 16 NDA (New Drug Application) 196 22 Nebcin® (tobramycin) 56 N 16 Necatoramericanus 163,165 16 NADH-Cytochrom bs-Reductase 440 17 Necator american us 160 22 Nadisan® (carbutamide) 80 18 Necator american us 199 16 Na-Dodecylsulfat (SDS) 366 19 Necator american us 17,25,29,36,46,56, 17 Naftamon® (bephenium hydroxynaph- 64,70,81,86,90,96, 161, 170, 173 thoate) 158 20 Necator american us 453 17 Nagronol® (suramin sodium) 132 17 Necatorina® (carbon tetrachloride) 116 20 58, 89 22 Negram® (nalidixic acid) 34 21 Nalidixic acid (Negram®, NegGram®, 21 NegGram® (nalidixic acid) II Nogram®) 11,62 22 NegGram® (nalidixic acid) 34 17 Neguvon® (trichlorfon) 128 Index Vol. 16-23 267

17 Nema8 (tetrachlorethylene) 130 16 Nicotinamidase 436 16 Nematocidal activity 166 17 24 16 Nematodes 158 16 217 17 Nematodes 122, 155 20 Nicotine 200, 335 20 Nematodes 350 19 Nicotinic acid 521 16 Nematodiasis 158 22 Nicotinic acid 86 17 Nematodirus battus 165 20 Nifedipin (Adalat®) 241,407 17 Nemazine8 (phenothiazine) 131 20 32, 225 20 Nembutal8 () 387 18 Nifurtimox (Lampit®) 323 17 Nemural® (drocarbil) 121 22 - 45 18 Neoarsphenamine 331 17 Nigericin 68 17 Neoascaris vitulorum 157 20 Nikethamide (Coramine®) 397 19 Neo Bedermin® 103 18 Nilevar® () 451 17 Neocuproine 14 22 Nilevar® (norethandrolone) 70 17 Neohydrazid® (cyanacethydrazide) 131 17 Nilodin® (lucanthone) 115 22 Neomercazole® (carbimazo1e) 77 17 Nilverm® (tetramisole) 125 16 Neomycin (Mycifradin®) 314 17 Nilzan 166 20 - 444 22 Nimetazepam (Erimin8 ) 262 22 - 56 20 441 22 Neomycin B 56 23 Nippostrongylus brasiliensis 48 18 Neomycin E 422 16 Niridazole (Ciba 32644-Ba; Ambil- 18 Neomycin F 422 har®) 14, 16,22 22 Neopinone 152 17 - 117,138,142,145-147,178,182,261 16 Neoplasia 80 18 - 327 20 Neoplasm, drug resistance 480 19 - 153, 154 20 Neostibosan® (ethylstibamine) 442 20 - 448,587 19 329,521 22 - 47 20 Neosynephrine® () 419 16 Niridazole, Cl4-labelled 21 22 Neoteben® (isoniazid) 34 16 Niridazole congeners 16, 17 20 Nepresol® (dihydralazine) 409 16 Niridazole hydroxylamino derivatives 21 16 Nervenwachstumsfaktor 374, 378 16 Niridazole schistosomicidal action 19 20 Nethalide® (pronethalol) 28 16 Niridazole side effects 22 18 Neuramidinase 255 22 Nisentil® (alphaprodine) 172 20 Neuramidinase 328 17 Nistatin 67 17 Neuraminic acid 79 20 Nitrazepam (Mogadon®) 389, 393 20 Neurochemical systems 301 22 - 261,356,366 16 Neurochemistry 354 20 Nitrimidazine 439 19 Neuromuscular irritability 216 19 Nitroblue tetrazolium test 245 19 Neuromuscular mechanisms 148 17 7-Nitro-6-demethyl-6-deoxytetracy- 16 Neuron 216 cline 222 21 Neuron 411 22 Nitrofural (nitrofurazone, Furacin®) 33 16 Neuronal activity 212 16 60 19 Neuronal membranes 303 21 Nitrofurantoin (Furadantin®) 351 20 Neuropeptides 285 22 - 33 16 Neurophysin 374 20 Nitrofurazone (Furacin®) 446 16 Neurotoxin 378 21 - 352 20 Neurotransmitters 288 17 Nitrogen mustard (HN2, mechlor- 20 Neutrophiles 577 ethamine) 349 16 New Drug Application (NDA) 196 20 - 467,480 16 343 23 - 38 20 Nialamide 217 20 Nitroglycerin 406 17 Nicarbazin 273 17 Nitromin 349 20 235 17 5-Nitro-I,10-phenanthroline 14 17 Nic1ofolan (menichiophoIan, Bayer 9015, 17 1-{3-[(4-Nitroso-I-naphthyl)amino]pro- Bilevon-M®) 134 pyl}piperidine 259, 268 17 Nic10samide (2', 5-dichioro-4'- nitrosalicyI• 20 Nitrosoureas 469 anilide, phenasaI, Yomesan®) 119, 138, 16 Nitrothiazoles 15 139,148-154,296,297 17 5-Nitro-4-thiazolines 264 18 - 198 16 (5-Nitro-4-thiazolin-2-ylidene) 15, 20 - 447 18 22 - 46 17 1-(5-Nitro-2-thiazolyl)hydantoin 270 268 Index Vol. 16-23

17 1-(5-Nitro-2-thiazolyl)-2-pyrro• 16 Notice of Claimed Investigational Exemp• lidinone 261 tion for a New Drug (IND) 196 17 2-[2-(5-Nitro-2-thiazolyl)vinyl)pyri• 20 Novalgin® (noramidopyrinium methansul- dine 264 fonate) 401 17 2-(5-Nitro-2-thienyl)benzimidazoles 307 17 Novazole® (rafoxanide) liS 17 Nitroxynil (4-cyano-2-iodo-6-nitrophenol; 20 Noveril® (dibenzepin) 394 Trodax®) 117,136,278,280 16 Novobiocin 318 16 NLT (Normal lymphocyte transfer) 102 21 Novobiocin 177 22 Nobrium® (medazepam) 249,261 20 Novocaine® () 403 22 Nocardicin A 53 20 Novonal 387 21 Nogram® (nalidixic acid) II 16 NRC (National Research Council) 201 20 Noludar® (methyprylon) 387 18 Nucleocapsid 253 17 Nonactin 69 16 Nucleosid-Diphosphat-Kinase 390 19 Non-agglutinable vibrios 508 20 Nupercaine® (cinchocaine) 403 16 Nonane-I,9-dioic acid 235 18 322,418 16 Nonanoic acid 244 22 Nystatin 97, 101 17 Non-electrolytes, transport of 69 17 Noradrenalin 491 o 20 Noradrenalin 410 16 Octadecanoic acid 244 22 Noradrenalin 368 16 [J-I4C)-cis, cis-Ll9, 12-0ctadecadienoic 20 Noradrenaline 410 acid 288 20 6-Noralkyl-Ilp-methyl-2,6-methano-3- 16 cis-Octadec-9-enoic acid 287 benzazocines 63 16 [J-I4C)-trans-Octadec-9-enoic acid 289 20 Noramidopyrinium methansulfonate 18 Octafluorocyclobutane 382 (Novalgin®) 401 20 Octahydrobenzofg)quinolines 74 20 Norcyclazocine 77 23 1,2,3,4,6,7,12, 12a-Octahydropyrazino- 20 Norcyclazocine glucuronide 77 [2', I': 6, l)pyrido(3,4-b)indoles 214 16 220,336,346 16 Octane-I,8-dioic acid 235 19 Norepinephrine 149 17 1,2, 8-0ctanetricarboxylic acid 416 20 Norepinephrine 219,220 16 Octanoic acid 243 21 Norepinephrine 420 23 n-Octanol 102 20 Norepinephrine biosynthesis 218,219 17 Octyl-(7 -carbomethoxyheptyl )butyrolac- 18 Norethandrolone (Nilevar®) 451 tone 418 21 - 348 23 Oedema 30 22 - 70 17 Oesophagostomum columbianum 165 21 Norethindrone (Norlutin®) 298 21 Oestradiol 323, 333 22 - 72 21 Oestradiol cyclopentyl propionate 319 18 N orethisterone 449 21 Oestriol 302 21 324,250 21 Oestrogen 298,318,348 21 N orethisterone acetate 300 23 Ogawa vaccine 14 21 Norethisterone oenanthate 303 21 Oleandomycin 175 18 Norethynodrel 449 22 Oleandomycin 58 21 Norethynodrel 298,348 17 Onchocerca volvulus 183 22 Norethynodrel 72 18 Onchocerca volvulus 142,260 18 Norgestrel (Microlut®) 449 19 Onchocerca volvulus 128 21 - 308,311 20 Onchocerca volvulus 456 22 - 74 17 Onchocerciasis 182 21 d- N orgestrel 300 18 Onchocerciasis 44 21 308,321 20 Onchocerciasis 456 22 Norlutin® (norethindrone) 72 22 Oncovin® (vincristine) 64 16 Normal lymphocyte transfer (NLT) 102 17 Oochoristica symmetrica 303 20 Normatensyl® 409 23 Opacity test 16 22 D-Normorphinan 167 20 dependence, treatment of 93 22 154 20 Opiate receptor 79 20 Nornaloxone 78 22 Opiate receptor 211 20 56 20 Opiate receptor isolation 79 20 Northebaine 53 20 Opiate receptor models 82 18 457 20 narcotic drugs 330, 332 19 Notatin 286 22 Opioid pep tides 195 20 Notezine® (diethylcarbamazine) 455 20 330 Index Vol. 16-23 269

20 Opioid receptor interaction 333 17 15-0xo-13,I4-dihydroprostaglandin 20 Opioid receptor, sodium effect on 331 F1a 444 20 Opipramol (Insidon®) 394 22 Oxolin 302 17 Opisthorchiasis 138, 276 21 Oxolinic acid 31 20 Opisthorchis 450 17 15-0xoprostaglandin E, 445,446 17 Opisthorchis felineus 138, 276 16 346,350 17 Opisthorchis viverrini 138, 288 20 (Trasicor®) 34,36,221,226, 19 Opisthotonus 201 229,230,411 22 alkaloids 151 20 p-Oxprenolo1 227 22 Orabolin® (ethylestrenol) 70 22 Oxyamylose 273 21 Oral contraceptives 313 17 Oxyclozanide (3,3',5,5' ,6-pentachloro-2'• 22 Orbenin® (cloxacillin) 50 hydroxysalicylanilide; Zanil®) 115, 135, 20 Orciprenaline (Alupent®) 419 281 21 ORF 1616 [l-(N,N-diethy1carbamyl• 20 Oxyfedrin (Ildamen®) 406 methyl)-2,4-dinitropyrrole] 352 17 Oxyformycin B 344 21 ORF 3858 (2-methyl-2-ethyl-4-phenyl-4- 20 Oxygen metabolism 537 cyc10hexene carboxylic acid) 322 17 Oxygen transport 92 22 Orgametril® (lynestrenol) 74 17 8-0xy-6-mercaptopurine 340 22 Orinase® () 80 22 Oxymetholone (Anadrol®) 69 22 Oripavin 152 22 Oxymorphine 151 22 Orisul® (sulfaphenazole) 31 20 56 16 Ornithin-Aminotransferase 400 20 Oxyntel pamoate 453 18 426 17 Oxyphenbutazone (Tanderi1®) 401 23 Ornithine decarboxylase (ODC) 90 20 - 490 20 Orudis® (ketoprofen) 402 20 (Antrenyl®) 420 17 Osmosis 93 17 (Terramycin®) 211,212, 17 Osmotic pressure 92 228 17 Ostertagia ostertagi 165 18 - 331 16 17p-Ostrol-Dehydrogenase 370,394 22 - 53 20 Otrivine® () 420 20 Oxytocin 286 17 Ouabain 35,67 17 Oxytremorine 26 16 Ovalacin 91 17 Oxyuriasis 171 23 Ovalbumin 45 17 Oxyuris equi 172 21 Overpopulation 295 23 Ovomucoid 33 P 21 Ovulation inhibition 298 20 Pactamycin 585 21 Ovum transport 323, 373 22 Palfium® (dextromoramide) 189 16 Oxacillin (Bactoci11®, Prostaphlin®, Stape- 18 Palitantin 331 nor®) 314,322 16 Palmitic acid-I-'''C 277 22 - 50 17 1-Palmitoyl-2-([2' -'''C]-eicosatrienoyl)gly- 17 (UK 4271) 253 cero-3-phosphory1choline 440 20 - 448 20 Paludrine® (chloroguanide, proguanil) 435 22 Oxandrolone (Anavar®) 70 22 Paludrine® (chloroguanide, proguanil) 44 20 Oxanthel pamoate 453 18 PAM-I,392 (2,4-diamino-6-[(3,4-dichloro- 17 Oxaprostaglandins 468 benzyl)amino ]quinazoline 110 17 7-0xa-13-prostynoic acid (compound 22 (Plasmochin®) 40 19396) 469 18 328 18 (Serax®, Serenid®) 434 22 Panacid® (piromidic acid) 34 20 - 393 16 Pankreasamylase 370 22 - 242 20 Panparnit® (caramiphen) 420 22 (Serenal®) 252 22 86 20 Oxedrin (Sympatol®) 411 22 211 16 a-Oxidation, mechanism of 278 20 406 16 w-Oxidation 232,233,243 20 400 20 62, 83 22 Parachlorophenylalanine 369 22 Oxilorphan 163 23 Parachor 135 22 Oxine 128 23 Paracyclophane 133 20 Oxisuran 587 17 Parafilaria bovicola 183 17 Oxoallopurinol 340 17 Parafilaria sahaii 183 17 15-0xo-dihydroprostaglandin E, 441,446 17 Parafilariasis 183 17 15-0xo-13,14-dihydroprostaglandin E2 444 17 Paragonimiasis 138, 292 270 Index Vol. 16-23

20 Paragonimiasis 450 21 Penicillin 131 17 Paragonimus westermani 292 23 Penicillin 51 18 Paragonimus westermani 197 16 Penicillin G 313 19 210,225,246,330,362 21 Penicillin G 176 19 Paralysis 298, 445 22 Penicillin G 50 22 Paramethasone 74 22 Penicillin V 50 22 (Haldrone®) 75 16 Penicillinase 326 20 Paramomycin (Humatin®) 447 19 Penicillium notatum 286 17 Paramphistomiasis 139 17 3,3',5,5',6-Pentachloro-2' -hydroxysalicyl- 17 Paramphistomum microbothrium 139,292 anilide (oxyclozanide, Zanil®) 281 16 Paramyosin 378 22 Pentachlorophenyl dodecanoate 128 17 (E 6(0) 489 20 Pentamethonium 200 20 Paraphenylquinone 46 18 Pentamidine (Lomidine®) 318 17 Pararosaniline [tris(p-aminophenyl)carbo- 20 - 443 nium, TAC] 118,255 22 - 45 17 Pararosaniline pamoate 147 20 Pentazocine (Fortral®, Talwin®) 62,64,75, 17 Parascaris equorum 156 81,89,398,399 18 Parasites 181 22 - 160,211 19 Parasitic diseases 147 20 Pentetrazole (Cardiazol®) 397 19 Parasitic diseases control 50 22 Pentizidone sodium 55 20 Parasitic infections 355, 434 18 Pentobarbital (Nembutal®) 453 18 Parasitoses 192 20 - 378 19 Parasitosis, intestinal 10 21 - 113 17 (E 605) 489 22 Pentobarbitone 362 16 Parbendazole (Helmatac®, Verminum®, 20 Pentolium tartrate 20 I Worm Guard®) 159, 160 20 Pentostam® () 442 17 - 126,157,164,170,174 20 Pentothal® (thiopental) 387 22 - 49 16 Peptidase 328 19 Paresis 445 18 Pep tides 425 17 Pargonyl® (paromomycin) 122 20 Pep tides 294 16 220, 349 22 Pep tides 308 20 Pargyline 217 23 Peptides 57 16 Parkinsonism 338,343 16 Peptidyl-5-hydroxylysine 296 20 Parkinson's disease 423 16 Peptidyl-4-hydroxyproline 293 20 Pamate® () 396 19 Peptone water culture 472 17 Paromomycin (Humatin®, Monomycin A, 18 455 Pargonyl®) 122, 148, 151, 153, 154 20 Periactin® (cyproheptadine) 426 18 - 330 20 Perolysen® () 410 20 - 447 16 Peroxidase 406 17 Paromomycin sulphate 302 17 11-Peroxy-8, 12, 14-eicosatri-enoic acid 436, 18 Paromomycin I 422 437 18 Paromomycin II 422 18 433 23 Partition coefficients 102, 112, 119 20 Persantin® (dipyridamole) 406 23 Partition coefficient-calculation 107 19 Pertussis 347, 356 18 PAS (p-aminosalicylic acid) 212 23 Pertussis 14 22 PAS (p-aminosalicylic acid) 34 19 Pertussis agglutinin 180 19 Pasteurella haemolytica 587 19 Pertussis agglutinogens 345 19 Pasteurella pestis 546 23 Pertussis agglutinogens 16 19 Pasteurella septica 546 19 Pertussis antibodies 178 20 pazoxide 233 19 Pertussis antigens 343 16 P-Creatine 345 19 Pertussis epidemiology 257 16 Pea leaves 281 19 Pertussis infection 184,257,344 22 Pecilocin 130 19 Pertussis immunization 261,358 20 Pempidine (Perolysen®) 202,410 19 Pertussis serotypes 342, 348 22 Penbritin® (ampicillin) 50 19 Pertussis strains 342 20 Pendiomid® (azamethonium bromide) 409 23 Pertussis toxins 13 20 Penicillamine 362 19 Pertussis vaccines 178,229,277,341 16 d- Penicillamine 88, 118 23 Pertussis vaccines 12, 16 18 Penicillin 331 19 Pertussis vaccine test 350 19 Penicillin 289, 330, 393, 413, 467 17 Pethidine (meperidine, Dolantin®) 488 20 Penicillin 440 20 - 398 Index Vol. 16-23 271

22 Pethidine (meperidine, Dolantinill) 168, 16 Phenylalanin-Hydroxylase 406 211 23 Phenylalanyl- 34 17 Ph 1882 (bromofenfos, Acedist®) 113 16 Phenylalanyl-tRNA-Synthetase 404,408 16 PHA (Phytohemagglutinin) 73, III 22 5-Phenyl-l,5-benzodiazepinediones 258 16 Phagocytosis 316 22 5-Phenyl-2,4-benzodiazepinones 259 23 Phagocytosis 15 22 5-Phenyl-l,4-benzodiazepin-2-ones 242 22 Phanquinone (Entobex®) 42 17 Phenylbutazone (Butazolidineill) 17,23,26, 20 15, 19, 160, 182 75,490 20 Pharmaceutical Manufacturers Association 20 - 401 (PMA) 162 23 - 114, 179 20 Pharmaceutical research 192, 511 17 3-Phenyl-4-[( dialkylamino )alkyl]pyrazol-5- 23 Pharmaceutical research 52 ols 309 21 124 17 1,4-Phenylenebis(dithiocarbamic acid es• 20 Pharmacological research 16 ters) 289 20 Pharmacological test system 145 18 4',4'" -fp-Phenylenebis(methylidyneimino• 16 Pharmacology 199 p-phenylenesulfonyl)]bisacetanilide 163 20 Pharmacology 146 16 Phenylene diisothiocyanate (1,4-phenyl• 18 Phebotomus argentipes 283 enediisothioxyanate, 1,4-phenylenediiso• 20 400 cyanate, bitoscanate) 158, 171 23 Phenacetin 114 17 Phenylene diisothiocyanate (1,4-phenyl• 17 Phenalglycodol 25 enediisothiocyanate, 1,4-phenylenediiso• 23 Phenanthrene carbinols 210 cyanate, bitoscanate) 300 17 o-Phenanthroline 496 19 Phenylene diisothiocyanate (1,4-phenyl• 17 1,100Phenanthroline 14 enediisothiocyanate, 1,4-phenylenediiso• 17 Phenasal (niciosamide) 119,297 cyanate, bitoscanate) 40 20 Phenazone (antipyrin) 401 20 Phenylephrine (Neosynephrine®) 28,419 20 Phenbenzamine (Antergan®) 424 16 Phenylethylhexylketone 262 20 Phenbutol 227 23 Phenyl-p-D-glycosides 139 21 113 17 Phenylisopropylhydrazine 25 20 Phenelzine (Nardil®) 217,395 17 4-[(5-Phenylpentyl)oxy]-m-anisidine, 22 - 365 methanesulphonate of 255 20 Phenergan® () 426 20 4-Phenylpiperidines 71 23 142 22 4-Phenylpiperidines 168 22 80 23 Phenylpropanes 109 16 Phenindiamine (Thephorin®) 342 21 17-Phenyl-18,19,20-trinorprostaglandin 20 - 426 F2a 326 20 Phenindione (Danilone®) 404 17 Phenyramidol 26 20 217 20 Phenytoin (Dilantin®) 387 20 Phenmetrazine (Preiudine®) 419 23 - 114 16 - 249,254 16 Phenzidole 159 17 - 494 17 Phloretine 70 18 - 453 23 Phorbol esters 67 20 - 387 23 Phorbol-12,13-diesters 171 19 Phenobarbitone 246, 294, 298, 330, 362, 16 Phosphatase,alkalische 392,398,402,436 379 16 Phosphatase, saure 392,436 17 Phenobutiodil [2-(2,4,6-triiodo- 17 Phosphatidic acid 78 phenoxy)butyric acid, Trijobil®] 299 17 Phosphatidyicholine 77 22 29,46 17 78 23 Phenols 105 17 Phosphatidylserine 78 22 211 23 Phosphatidylserine 44 16 Phenothiazine (Antiverm®, Helmetina®, 20 Phosphodiesterase 329 Nemazine®, Vermitin®) 159 16 Phosphoenolpyruvat-Carboxylase 404, 17 - 131,168 414,440 17 76 16 Phosphoenolpyruvat-Carboxytrans- 18 Phenothiazines 433 phosphorylase 414 21 Phenothiazines 439 16 Phosphofruktokinase 400,416 23 Phenoxyacetic acids 108 19 Phosphofruktokinase 153 17 Phenoxyalkanes 285 16 Phosphoglucose-Isomerase 398 21 hydrochloride 358 17 Phosphoglycerate kinase 66 17 (Regitine®) 51 16 Phosphoglycerat-Mutase 390 20 - 206,221,426,413 16 3-Phosphoglycerat-Phosphatase 438 16 /-Phenylalanine mustard 86 272 Index Vol. 16-23

17 Phospholipase A 81,440 18 Pneumocystis carinii 319 16 434 19 Pneumonia 307 23 Phospholipase A2 72,91 23 Podolide 83 17 Phospholipids 72, 77 17 Podophyllotoxin 382 22 Phosphonoacetic acid 63, 305 22 Podophyllotoxin 64 16 Phosphopyruvat-Hydratase 436 23 Podophyllum 69 17 Phosphoramide mustard 350, 359 20 Podophyllum derivatives 473 16 Phosphoribosylpyrophosphat-Aminotrans• 20 Polamidon® (methadone) 398 ferase 418 23 Polio 13 16 Phosphoribosylpyrophosphat-Synthe- 18 Poliomyelitis 279 tase 442 19 Poliomyelitis 256 16 Phosphorylase B Kinase 420 23 Poliomyelitis 21 17 Photodissociation 493 16 Poliomyelitis-Virus 384 16 C-Phycocyanin 378,430 19 Polio vaccine 276 16 C-Phycoerythrin 430 23 Polio vaccine II 22 Phylloquinone (vitamin K 1) 85 23 Polio virus II 16 346,356 22 Polonowski rearrangement 241 22 Physostigmine 368 22 Polyacrylic acid 272 16 Phytanic acid 285 23 Polyarthritis 47 16 [U- 14C]-Phytanic acid 286 22 Polycillin® (ampicillin) 50 16 Phytochrom 378 22 Polycytidylic acid 271 16 Phytohamagglutinin 374, 376 22 Polyene antibiotics 95 16 Phytohemagglutinin (PHA) 73, III 22 Polyene antibiotics, alkyl esters 10 I 20 Picodralazine 409 22 Polyene antibiotics, classification 96 17 Picolinaldehyde thiosemicarbazone 347 22 Polyinosinic acid 271 18 Pikromycin 418 17 Polymyxin B 68 18 Pimaricin 418 19 Polymyxin B 466 21 415,416 22 Polymyxin B 59 22 Pinazepam (Domar®) 262 22 Polymyxin E 59 20 (Visken®) 34,36,226,230,411 19 Polynucleotides 281 . 16 Pinworm 160, 163 16 Polynucleotid-Phosphorylase 406 18 Pinworm 191 17 Polyphloretin phosphate 470 21 Pipemidic acid 81 16 Polysaccharid-Depolymerase 440 17 Piperazine (Antepar®) 126, 172 23 Polysaccharides 28 19 - 33,36, 149, 163, 166 17 Polystichin (aspidin) 120 20 - 451,452 20 Poly (Renese®) 210,417 22 - 48 23 Polyvalent vaccine 13 17 Piperazine adipate 174 20 Ponderal® (fenfluramine) 419 17 Piperazine hydrate 157 20 Ponstan® (mefenamic acid) 401 17 Piperonyl butoxide 13 19 Pontamine sky blue 505 20 200 17 Porfiromycin 364 21 432 16 Potassium 212,214 21 Piromidic acid (Panacid®) 79 17 Potassium antimony tartrate 244 22 - 34 17 (Soldactone®, Solu- 23 Pituitary hormones 57 dactone®) 47 20 (Sandomigran®) 426 22 - 76 20 Placidyl® (ethchlorvynol) 387 17 Potassium ion 75 19 Plague vaccine 275, 486 17 Potassium ion transport 63 22 Plasmochin® (pamaquine) 40 19 Potassium loss 529 17 Plasmodium berghei 263 22 Potassium prorenoate 76 18 Plasmodium berghei 102 22 Potassium sorbate 130 23 Plasmodium berghei 210 20 Povan® ( pamoate) 452 18 Plasmodium cynomolgi 110 22 Povan® (pyrvinium pamoate) 48 18 Plasmodiumfalciparum 101,249 16 PPD (Purified protein derivative) 102 20 Plasmodiumfalciparum 435 16 Pra-Phenol-Oxidase 392 18 Plasmodium gal/inaceum 110 20 Practolol (Eraldin®) 28,34,36,229,411 18 Plasmodium knowlesi III 19 methanesulphonate 330 18 Plasmodium malariae 101 20 Prantal® (diphemanil) 420 18 Plasmodium vivax 101 22 (Verstran®) 261 19 Pleurothotonus 201 22 Praziquantel (Droncit®) 49 17 Plexaura homomalla 472 20 Prazosine 233,415 Index Vol. 16-23 273

20 Preclinical evaluation 146 23 Promethazine (Phenerganll» 40, 114 21 Preclinical experiments 247 17 Prominticill (methyridine) 123 16 92, 103 22 Promintic® (methyridine) 49 17 Prednisolone 24,383 20 Pronase 79,332 20 Prednisolone 475, 583 20 Pronestyl® () 406 22 Prednisolone 74 20 Pronethalol (Alderlin®, Nethalide®) 28, 16 92 32,224,225,411 17 Prednisone 383 17 Prontosil rubrum 488 20 Prednisone 475 21 Prontosil rubrum 30 21 Prednisone 351 22 Propaderm® (beclomethasone 17,21-dipro- 22 Prednylidene (Oecortilen®) 75 pionate) 74 17 75 18 388 20 Preludin® (phenmetrazine) 419 17 m-(2-Propargyloxy)phenyl benzoate 309 21 Premarin® 310 18 Propellants 367 17 (Segontin®) 75 18 Propellants, pharmacologic action 391 20 - 406 18 Propellants toxicity 367 19 Presynaptic apparatus 303,318 22 Propionic acid 130 18 324 16 Propionyl Co-A-Carboxylase 418 20 Primaquine 435 16 Propiophenone 262 20 Primidone (Mysoline®) 387 22 206 22 Primobolan® (methenolone acetate) 69 18 Propoquin® (amopyroquine dihydrochlo- 20 Priscol® () 413 ride) 102 20 Privine® (naphazoline) 420 20 Propoxyphene (Oarvon®) 398 16 Probenecid (Benemid®) 337 22 - 189 20 - 402 16 Propranolol (Inderal®) 355 17 Procainamide (procaine amide 17 - 51 Pronestylll» 36,45,51,488 18 - 460 20 - 406 19 - 361 16 Procaine (Novocaine®) 215 20 - 28,33,36,224,225,226,411 20 - 403 23 - 54,118 19 Procaine penicillin 210,224,379 17 d-Propranolol 67 16 99 17 I-Propranolol 53 17 Procarbazine 370 20 Propylhexedrine (Benzedrexll» 419 18 Procarbazine 23 16 2-n-Propyloctadecanoic acid 236 20 Procarbazine 476 16 2-n-Propyltetradecanoic acid 236 16 Procarboxypeptidase A 394 22 Propylthiouracil 77 20 227 22 84 22 Pro Diaban® (glisoxepide) 80 17 Prostaglandin 413 23 Product patent protection 53 18 Prostaglandin 427 16 Proflavin 100 19 Prostaglandin 526 21 Progestasert® 65, 335 20 Prostaglandin 242 16 262 21 Prostaglandin 371 17 Progesterone 24, 493 23 Prostaglandin 54 21 Progesterone 298,320,348 17 Prostaglandin antagonist 468 22 Progesterone 68, 72 17 Prostaglandin analysis 428 21 Progestins 321 17 Prostaglandin antilipolytic action 466 20 Proguanil (chloroguanide, Paludrin®) 435 17 Prostaglandin antisecretory action 461 22 - 44 17 Prostaglandin biosynthesis 430, 433 20 287 17 Prostaglandin bronchodilator activity 462 22 Prolactin 360 17 Prostaglandin configuration 418 16 Proliferation 74 17 Prostaglandin effects 464 17 Proline 491 17 Prostaglandin enzymatic synthesis 439 20 Prolixin® (fluphenazine) 389 17 Prostaglandin isolation 413 16 Prolyl-tRNA-Synthetase 394 17 Prostaglandin metabolism 440 19 379 17 Prostaglandin nomenclature 420 22 Promedol 172 17 Prostaglandin occurrence 423 22 a-Promedol 181 17 Prostaglandin structure 415 22 p-Promedol 181 17 Prostaglandin synthese 470 22 y-Promedol 181 17 Prostaglandin synthetase 431, 433 20 Promethazine (Phenergan®) 426, 445 17 Prostaglandin vasodepressor activity 463 21 - 414 17 Prostaglandin LlI3-reductase 449 274 Index Vol. 16-23

17 Prostaglandin A isomerase 451 22 Pro-Viron® (mestero1one) 69,70 17 Prostaglandin A, (POA,) 417,430,451 23 Pruritus 31 18 Prostaglandin A, (POA,) 428 16 Pseudocholin-Esterase 440 17 Prostaglandin A" w-hydroxy1ation of 450 16 Pseudomonas aeruginosa 310 17 Prostaglandin A2 (POA2) 425 19 Pseudomonas aeruginosa 546 18 Prostaglandin A2 (POA2) 428 23 Pseudomonas aeruginosa 14 17 Prostaglandin B, (POB,) 415,430,451 19 Pseudomonas enteritidis 587 18 Prostaglandin B, (POB,) 428 16 Pseudomonas oleovorans 231,249 18 Prostaglandin B2 (POB2) 428 20 Psychopharmaceutical agents 389 17 Prostaglandin E, (POE,) 415,418,424, 18 Pteridine 299 429,430,434,441 21 Pulmonary embolism 315 18 Prostaglandin E, (POE,) 427 16 Purified protein derivative (PPD) 102 18 Prostaglandin E,-methy1ester 428 16 Purine analogs 93,94 17 (POE2) 418,424,429,430 22 Purinetho1® (mercaptopurine) 64 18 Prostaglandin E2 (POE2) 427,443 16 Purinnudeosid-Phosphory1ase 394 20 Prostaglandin E2 (POE2) 586 17 Purkinje fibers 36 21 Prostaglandin E2 (POE2) 327,371,374 16 Puromycin 89, 90 17 Prostaglandin E2 metabolism 442, 452, 453 16 Pyocyanase 310 17 Prostaglandin E3 (POE3) 418,424,429,430 22 Pyopen ® (carbenicillin) 51 18 Prostaglandin E3 (POE3) 427 20 Pyramidon® (aminophenazone) 401 17 Prostaglandin F,. (POF,.) 415,418,424, 22 Pyran 272 437 16 Pyrante1 (Banminth®, Combantrin®, Stron- 18 Prostaglandin F,. (POF,.) 427 gid®) 158, 164, 165, 167 17 Prostaglandin F IP 415,424 17 - 124,155,160,165,172 17 Prostaglandin Flo (POFlo) 420,431,441 18 - 158, 164, 167 18 Prostaglandin Flo (POFlo) 428,443,446 19 - 33,36,40 21 Prostaglandin Flo (POFlo) 325,371,374 20 - 451 22 Prostaglandin Flo (POFlo) 84 22 - 48 17 Prostaglandin Flo' metabolism of 452,453 18 Pyrazinamide (Tebrazid®) 212 17 Prostaglandin F 3a 420, 425 22 - 36 17 Prostaglandin F 7/1 420 21 Pyrazinopyridoindoies 455 17 Prostaglandin F 3P 420 22 Pyrazo1o-1,4-benzodiazepinones 257 22 Prosta1ene (Synchrocept@) 84 21 Pyrazoio[3,4-b]pyridines 91 17 Prostane 423 22 Pyrazo1o[3,4-b]quinolines 275 17 Prostanoic acid 420 20 Pyribenzamine® () 426 22 Prostaphlin® (oxacillin) 50 22 Pyrido-1,4-diazepinones 255 17 Prostate glands 413 21 Pyridopyrazines 88 20 Prosympal 415 21 Pyrido[2,3-b]pyrazines 78 20 Protein 332 21 Pyridopyrimidines 83 16 a-Protein 105 21 Pyrido[2,3-d ] 69 16 Protein, C-reaktives 376 21 Pyrido[3,2-d ]pyrimidines 69 16 Protein, Denaturantien 366 16 Pyridoxal-5' -phosphate 222 16 Protein, hydrophobes 430 16 Pyridoxal-phosphate-y-glutamylhydra• 16 Proteine 365,366,382 zone 223 16 Proteine, oligomere 366 16 Pyridoxaminpyruvat-Aminotrans- 22 Proteine synthesis 361 ferase 402 16 Protein-Kinase 400 22 Pyridoxine (vitamin B6) 86 16 Protein-Praa1bumin-Komp1ex 376 18 Pyrimethamine (Daraprim®) 107, 328 17 Proteins 64,81 20 - 336,435 21 Proteins 365 22 - 44 16 Proteins (pre-early) 430 16 Pyrimidines analogs 97 16 Prothidium bromide 99 20 Pyrimidone (Mysoline®) 387 16 Protocollagen-Prolin-Hydroxy1ase 406 21 Pyrimidopyridazine derivates 89 16 Pro top lasts 329 21 Pyrogallol 191 17 Protostrongylus rufescens 178 16 Pyrophosphatase, anorganische 390, 398 23 Protozoal vaccines IS 16 Pyruvat-Carboxy1ase 418 18 457 16 Pyruvat-Decarboxylase 404 16 Provera® (medroxyprogesterone ace• 16 Pyruvat-Dehydrogenase 406,410,418 tate) 92 16 Pyruvat-Dehydrogenasekomp1ex 420 22 Provera® (medroxyprogesterone ace• 16 Pyruvat-Kinase 402,408,438 tate) 73 17 Pyrvinium (Povan®) 127,170,173 19 - 152 Index Vol. 16-23 275

20 Pyrvinium (Povan4D ) 452 17 Red blood cell (human) 60 22 - 48 17 Red blood cell (trout) 61 17 Red blood cell, diffusion in 61 17 Red blood cell, geometry of 91 Q 17 Red blood cell membrane 60,87 23 Quantitative structure activity relationships 17 Red blood cell membrane, chemical (QSAR) 98, 200 4D composition of 76 20 Questran (cholestyramine) 418 17 Red blood cell membrane, 16 Quinacrine (Atabrine4D , Atebrin4D, Acri- 4D permeability of 64 chine , mepacrine) 100 17 Red blood cell, transport in 61 17 - 119,148,152,294 22 Redul® (glymidine) 81 18 - 325 16 Refsum's disease 285 20 - 441 20 Regitine® (phentolamin~) 413 21 - 343 19 Rehydration therapy 527 22 - 38 22 Quinapyramine (Antrycide4D ) 42 16 Renal abscess 322 20 Renal transplantation 584 18 Quinaspar 116 20 Renese® () 417 22 Quinazoline 3-oxides 233 21 302 20 Renin-angiotensin system 245 16 RES (reticuloendothelial system) 73, 101 20 210 21 acetate 302 20 208 17 24,36,51 20 Research institutes 20 16 (Serpasil®) 91,220,345,346, 20 Quinidine 406 17 24 349 20 Quinine 435 17 - 75 22 Quinine 40 19 - 149 21 Quinoline derivates 12 20 - 206,389,407 17 Quinolinemethanols 270 21 - 199 20 3-Quinuclidinyl benzilate 335 22 - 368 22 Quinuronium sulfate (Acaprin4D) 42 20 Reserpine, mode of action 207 17 Resorantel (4'-bromo-y-resorcylanilide; Resorcylamin, Terenol®) 120, 139, lSI, R 154,284,298 21 R2323 (l3-ethyl-17-hydroxy-18,19-dinor- 17 Resorcinol 74 17a-pregn-4,9,II-trien-20-yn-3-one) 308, 17 Resorcylamin® (resorantel) 120 322,350 20 Respiratory tract, infeCtion of 361, 363 22 R34000 11 0 20 Resyl® (guaiphenesin) 392 16 Rabbit antilymphocyte fraction serum 16 Reticuloendothelial system (RES) 73, 101 (RALfS) 103 17 Reticulum, endoplasmic 488 18 Rabies 240 22 Retinol (vitamin A) 84 18 Rabies virus 240 21 Retroprogestogen 321 16 Radiation 79 22 Reverin® (politetracycline) 53 16 Rafoxanide (Flukanide®, Novazole®, 16 Rezeptorprotein, cholinerg. 380 Ranide®) 172 20 Rheumatic diseases 362 17 - 115,135,165,272,282,283,298 20 Rheumatoid arthritis 362 17 Raillietina cesticillus 294, 299 22 Rhodanine 289 17 Raillietina echinobothrida 294 16 /-Rhodinic acid 242,243 17 Raillietina tetragona 294 22 Ribavirin (Virazole®) 61,278,290 16 RALfS (rabbit antilymphocyte fraction 22 Riboflavine (vitamin B:z) 86 serum) 103 17 1-P-D-Ribofuranosyl-4-hydroxy-3,4,5,6- 17 Rametin® (naphthalophos) 129 tetrahydro-2(lH)-pyrimidinone 332 22 Ramihyphin A 132 17 1-P-D-Ribofuranosylpyrazolo[3,4-d]pyrimi- 17 Ranide® (rafoxanide) 282 dine-4(5H)-one 343 17 Ranestol® (triclofenol, piperazine) 127 16 Ribonucleic acid (RNA) 215 22 Rapamycin 131 16 Ribonucleotid-Diphosphat-Reductase 410 22 Rastinon® (tolbutamide) 80 16 Ribosomale Proteine 432 17 RD 12,869 (6-chloro-5-{[2-(diethylami- 16 Ribu1ose-Diphosphat 442 no)ethyl]amino}-8-methy1quinoline) 254 16 Ribulose 1,5-diphosphat-Carboxy1ase 416, 20 Reagin 589 418 20 Receptor research 342 16 L-Ribu1ose-Kinase 394 21 Receptor-site models 117 23 71 16 Red blood cell (RBC) 88 22 Rifaldin® (rifampicin) 59 276 Index Vol. 16-23

18 Rifampicin (Rifaldin®, Rimactan®) 212, 22 Saramycetin 125 324 23 Sarcina lutea 180 22 - 59,133 20 Saturation metabolism 526 21 Rifampin 131,176 22 Rifampin 311 19 Schick test 339 22 Rifamycin 59 17 Schistosoma intercalatum 139, 147 22 Rimactan® (rifampicin) 59 16 Schistosoma mansoni 12,22, 39, 49 22 Rimantadine 277,302 17 Schistosoma mansoni 139,244 22 Rimifon® (isoniazid) 34 18 Schistosoma mansoni 15,200 19 Rinderpest 274 20 Schistosoma mansoni 448 19 Ringer injection 511 16 Schistosoma haematobium 12,22,49 22 (CI-683) 257 17 Schistosoma haematobium 139,245 17 Ripercol® (tetramisole) 125 18 Schistosoma haematobium 15,200 16 Ristocetin 313 20 Schistosoma haematobium 448 19 Risus sardonicus 202,216 16 Schistosomajaponicum 12,23,60 20 Ritalin® (methylphenidate) 397 17 Schistosomajaponicum 139,253 18 RL-712 310 18 Schistosomajaponicum 15,200 16 RNA (ribonucleic acid) 215 19 Schistosomajaponicum 119 16 RNA-Polymerase 388,414,416,418,440 20 Schistosoma japonicum 448 18 RNA-Polymerase 253 17 Schistosoma mattheei 147,275 20 Robinul® (glycopyrrolate) 420 17 Schistosomiasis 139, 140,243 17 Rodameb® (diphetarsone) 123 18 Schistosomiasis 15,44,280 19 Rodameb® (diphetarsone) 36 19 Schistosomiasis 119 22 Rohypnol® (fiunitrazepam) 262 20 Schistosomiasis 448 22 Rolitetracycline (Reverin®) 53 20 Schizophrenia 38 17 Ronnel (fenchlorphos, Ectoral®, Trole- 18 Schwann cells 57 ne®) 128 19 p-Rosani1ine 150 17 Scolaban® (bunamidine) 121,302 17 Rosapin® (desaspidin) 120 16 341,351 23 71 22 Scopolamine 368 16 Roundworm 2, 158, 160, 170 20 Screening II 18 Roundworm 191 16 SDS (Na-Dodecylsulfat) 366 17 R.P. 14015 (trans-I,4-di[(2-isothiocyana- 19 Sea-fish 499 to )ethyl]cyclohexane) 300 20 Sedormid® (apronalide) 387 19 Rubella 280 20 Segontin® (prenylamine) 406 16 Rubidomycin 91 19 Senna 526 16 Rubredoxin 249,250 23 S-180 enzyme 61 16 Rubredoxin reductase 249 22 Sepazon® (cloxazolam) 252 16 Rue1ene 168 20 Septrim® (trimethoprim + sulphamethox- azole) 438 19 Sera 179 S 22 Serax® (oxazepam) 242 20 (Ventolin®) 419 20 Serenace® (haloperidol) 390 17 Salicylaldehyde 306 22 Serenal® (oxazolam) 252 22 Salicylamide 129 20 Serenid® (oxazepam) 393 20 400 16 Serin-Dehydrase 390 22 Salicylic acid 130 16 Serin-Transacetylase 402 23 Salicylic acid 179 22 Seromycin® (cycloserine) 55 19 Saline loss 528 16 Serotonin (5-HT, 5-hydroxytrypt• 19 Salk vaccine 276 amine) 221,336,341 17 Salmo gairdnerii 293 19 Serotonin (5-HT, 5-hydroxytrypt- 19 Salmonella typhimurium 546 amine) 149 19 Salmonellosis 570 20 SerpasiJ® (reserpine) 407 17 Salmo trutta L. 79 19 Serum IgE 122 22 Salvarsan® (arsphenamine) 37 16 Seryl-tRNA-Synthetase 394,398 20 Sandomigran® (pizotifen) 426 19 Sewage 571 20 Sandostene® () 426 19 Shigella flexneri 573, 574 20 Sanorex® (mazindol) 420 19 Shigella sonnei 573 19 149 19 Siderophilin 551 17 Saponin 81,94 19 Shigellosis 570 20 Saralasin 246 23 Shigellosis 13 Index Vol. 16-23 277

23 Shikimic acid 71 17 Sphingomye1ins 72, 78 21 Silastic® capsules 305 17 Spirocerca lupi 171 21 Silastic 382® ring 307 17 Spirometra mansonoides 148,303 21 Silicone 345 20 Spironolactone (Aldactone®) 213 22 Silubin® (buformin) 80 22 - 76 22 Silymarin 312 18 Spiroperidol 437 20 Sinequan® (doxepin) 394 21 Spiroperidol 415 20 Singoserp® () 408 21 Spontaneous drug monitoring 254 17 Sinoatrial node 44 17 SQ 18506 (trans-5-amino-3-[2-(5-nitro-2- 22 Sirodesmin A 310 furyl)vinyl]-1,2,4-oxadiazole) 264,267 18 Sisomicin 423 17 SKF 525-A (2-diethylaminoethyI2,2- diphenylvalerate HCl) 13, 18, 27, 360, 372 22 Stanilolll> (spectinomycin) 56 17 SKF 2314 (2,2-diphenylvaleric acid) 18 22 Stanozol (Winstrol®) 69 17 SKF 8742-A (2-ethylaminoethyI2,2-diphe• 22 Stapenorlll> (oxacillin) 50 nylvalerate HBr) 24 22 Staphcillinlll> (methicillin) 50, 51 22 SKF 23880 A (cylooctylamine hydrochlo- 16 Staphylococcal infection 319 ride) 27 16 Staphylococci epitkrmidis 316 20 Skin infection 361 16 Staphylococcus aureus 311,313 19 Skin permeability 505 17 Staphylococcus aureus 223,234 19 Skin test 120, 128 16 Staphylococcus staphylolyticus 310, 328 22 Sleep mechanisms 367 16 Staphylolytic activity 313 22 Sleep research 355 22 Statolon 272 18 Smallpox 28,44,281 17 Stearic acid 435 19 Smallpox 255,274 21 Stelazine® 357 23 Smallpox 11 17 Stephanofilaria assamensis 183 17 SN-IO,275 (6,8-dichloro-2-phenyl-a-(2- 17 Stephanofilariasis 183 piperidyl)-4-quinoJinemethanol) 270 20 Stereoisomerism 103 22 Social pharmacology 11 20 Stereoisomers, biological activities of 104 16 Sodium 1_1"C acetate 282 20 Stereoselectivity data 114 17 Sodium antimonyl dimethylcysteine tar- 20 Stereoselectivity data, results 115 trate 112, 143, 146 20 Stereospecificity 12 20 Sodium antimony tartrate 449 23 Steric parameters 207 22 Sodium arsanilate (Atoxyl®) 40 20 hormones 296, 298 20 Sodium dipropylacetate (Depakine®) 424 21 Steroidal contraceptives 298 16 Sodium fiuoracetate 343 20 Steroid hormones, effects on biosynthe- 17 Sodium ion transport 63 sis 297 20 Sodium nitroprusside 232 20 Steroid receptors 300 16 98 18 429 17 Sodium salicylate 75 18 Stibacetin 306,311 18 Sodium stibogluconate (Pentostam®) 307 18 Stibamine 311 20 - 442 17 Stibocaptate (antimony dimercaptosucci• 23 Solapalmitine 76 nate Astiban®, TWSb/6) 112, 140, 143, 182 23 p-Solarmarine 86 22 - 47 17 Soidactonelll> (potassium canrenoate) 47 17 Stibophen (Antimosan®, Corystibin®, Fua- 22 Soludactone® (potassium canrenoate) 76 dinS) 112, 132, 144, 147, 183 20 Solustibosan® (sodium stibogluconate) 442 19 - 155 22 Solvoteben® (Tb IV) 34 22 - 47 23 Somatostatin 60 17 Stibunal® (antimony sodium tartrate) III 16 Somatotropes Hormon 374 20 Stiburealll> ( stibamine) 442 20 34, 36, 225 18 Stilbamidine 301,319 17 Soybean Jipoxidase 435 17 Stilbazium iodide (MonoparGD) 124, 171, 21 sulfate 374 174 19 Spatula Test 219 21 Stilboestrol 310, 323 22 Spectinomycin (Trobicin®, Stanilo®) 56 1'1 Stilesia globipunctata 154, 294 21 Sperm antigens 366 17 Stomach 459 21 Spermatogenesis 347 22 Stoxil® (idoxuridine) 61 21 Sperm enzymes 366 18 Streptococcusfaecalis 114 21 Sperm maturation 354 23 Streptococcus mutans 29 21 Sperm transport 312,356,375 16 Streptokinase 326 16 Spheroplasts 329 16 Streptolysin S 112 278 Index Vol. 16-23

17 Streptomyces achromogenes 368 20 Sulfadoxine (sulformethoxine, Fana- 16 Streptomyces antibioticus 299 Silllll) 436 17 Streptomyces aureofaciens 211 22 - 31 17 Streptomyces coeruleorubidus 373 22 Sulfaethidole (Globucidllll) 34 16 Streptomyces griseus 282 20 Sulfalene (sulphamethoxypyrazine, Kelfizi- 17 Streptomyces michiganensis 302 nallll) 436 17 Streptomyces noboritoensis 302 22 - 31 18 Streptomyces nodosus 320 22 Sulfamethoxazole (Gantanolllll ) 31 18 Streptomyces noursei 322 22 Sulfamethoxydiazine (Durenatllll ) 31 17 Streptomyces peucetius 373 22 Sulfamethoxypyridazine (Lederkynllll, 17 Streptomyces rimosus 212 Midicelllll) 31 16 Streptomycin 90 22 Sulfametrole 33 18 Streptomycin 212 16 Sulfanilamide (4-aminobenzenesulfon• 22 Streptomycin 56 amide) 259 17 Streptozotocin 368 18 Sulfanilamide (4-aminobenzenesulfon• 20 Streptozotocin 480 amide) 330 17 Strongyloides papil/osus 169 20 Sulfanilamide (4-aminobenzenesulfon• 16 Strongyloides stercoralis 160, 165 amide) 415 17 Strongyloides stercoralis 169 21 Sulfanilamide (4-aminobenzenesulfon- 18 Strongyloides stercoralis 199 amide) 31 19 Strongyloides stercoralis 18,29,41,42 22 Sulfaphenazole (Orisulllll ) 31 20 Strongyloides stercoralis 454 21 Sulfathiazole (Cibazolllll ) 31 17 Strongyloides westeri 170 20 Sulfinpyrazone (Anturanllll) 401,402 17 Strongyloidiasis 169 21 Sulfisoxazole (Gantrisinllll ) 31, 129 19 Strongyloidiasis 18,42 16 Sulfit-Oxidase 396 20 Strongyloidiasis 454 20 Sulfonal 387 23 Structure activity 170 21 174 16 Strychnine 349 18 4',4"'-Sulfonylbisacetanilide (acedapsone, 20 Stutgeronllll (cinnarizine) 426 Hansolarllll) 156 17 Styrydllll (styrylpyridinium) 124 18 4,4'-Sulfonyldianiline (dapsone, diamino• 16 Styrylpyridinium (Styrydllll) 173 diphenyl sulfone) 108, 155 17 - 124, 160 22 Sulformethoxine (sulfadoxine, Fana- silllll ) 31 17 SU-4885 (metyrapone,2-methyl-l,2-bis-[3- 17 Sulfuric acid 483 pyridyl]-I-propanone) 15 20 Sulindac (Clinorilllll ) 402 20 Suavitilllll (benact"jZine) 392 20 Sulphadoxine (Fanasilllll ) 436 17 Suberic acid, monomethyl ester of 416 20 Sulphamethoxypyrazine (Sulfalenellll ) 436 22 Sublimazellll (fentanyl) 185 17 Sulphaphenazole 26 23 Substructure 99, 134 17 2,2' -Sulphinylbis(4,6-dichlorophenol) 20 Subtilisin substrates III (Bitin S) 297 16 Subunit-Bindungstypen 368 20 Sulpiride (Dogmatilllll) 391 16 Subunits 365 16 Superoxid-Dismutase 388 16 Succinat-Dehydrogenase 396 17 Suramin sodium (Antrypolllll, Germaninllll , 19 Succindehydrogenase 308,319 Moranylllll, Naganoll111 ) 132, 183 17 Succinic acid 415 18 - 331 19 Succinic acid 286 19 - 155 21 Succinylcholine 113 20 - 445 16 Succinyl Co-A-Synthetase 402 22 - 38 23 Sucrose 28 22 Surfen CIIII (congasine) 42 17 Sugar phosphate 62 20 Suxamethonium (Anectinellll ) 422 23 Sugar infusions 28 20 Symmetrelllll (amantadine) 423 23 Sugar polymers 27 22 Symmetrelllll (amantadine) 62,277 23 Sugar polymers, adverse reaction 27 21 Sympathectomy 357 23 Sugar polymers, anaphylactoid reac- 20 Sympatolllll (oxedrin) 411 tions 30 22 Synalarllll (tluocinolone acetonide) 75 23 Sugar polymers resistance 46 19 Synaptic apparatus 304 22 Sulfacetamide (Albucidllll ) 31 22 Synchroceptllll (prostalene) 84 20 Sulfadiazine (Debenalllll ) 436, 437 17 Syngamiasis 177 22 - 31 17 Syngamus trachea 177 22 Sulfadimethoxine (Madribonllll ) 31 20 Synopenllll (chloropyramine) 426 22 Sulfadimidine 43 22 Synthalin 44 Index Vol. 16-23 279

22 Synthalin A 79 17 Telmid® (dithiazanine) 127 20 Synthetic drugs 10 17 Telmin® (mebendazole) 159 20 Synthetic products 144 22 Temazepam (Levanxol®) 242,261 20 Syntropan® (amprotropine) 420 22 Temgesic® (buprenorphine) 156, 157 17 Syphacia obvelata 296 17 Tenebrio molitor 294 19 Syphilis 281 19 Teniasis 20 23 Syphilis 20 17 Tenoban® (nemura1) 121 22 Syraprim® (trimethoprim) 44 17 Tenoban® (drocarbil) 121 20 Syrosingopine (Singoserp®) 208, 408 20 Tenormide 227 16 Systox 355 20 Tenormin® (ateno101) 237,411 20 TEPA (triethy1enephosphoramide) 468 T 20 (Brethine®) 419 16 Tabakmosaikvirus 384 17 Tereno1® (resorante1) 120, 284 17 TAC [pararosaniline; tris(p-aminophenyl) 17 Ternidens diminutus 171 carbonium] 118,255 17 Teroxa1ene 250 20 Tachyarrhythmias 37 22 Terramycin® (oxytetracycline) 53 18 Tachycardia 393 . 17 24, 25, 75 19 Tachycardia 246 20 Testosterone 475 20 Tacitin® (benzoctamine) 393 22 Testosterone 68 17 Taenia hydatigena 153 21 Testosterone oenanthate 348 17 Taenia ovis 153 21 348 17 Taenia pisifarmis 153,303 22 Testosterone propionate 68 17 Taenia saginata 152 23 Tetandrine 86 18 Taenia saginata 198 19 Tetano1ysine 307 19 Taenia saginata 20, 137 19 Tetanus 189,210,245,256,288,323,347, 20 Taenia saginata 447 356,439 17 Taenia serialis 300 23 Tetanus 11, 17 17 Taenia solium 152, 292 19 Tetanus antibodies 368 18 Taenia solium 197 19 Tetanus antitoxin serum 315 19 Taenia solium 20 19 Tetanus antitoxin therapy 398 20 Taenia solium 447 19 Tetanus attacks 213 17 Taenia taeniae/ormis 303 19 Tetanus clinical trials 372 19 Taenia taeniae/armis 54 19 Tetanus complications 202, 222 17 152 19 Tetanus death 203,223,439 17 Talodex® (fenthion) 128 19 Tetanus fever 197,216 22 Talwin® (pentazocine) 160 19 Tetanus frequency 191 16 «Tamm-Horsfall»-Glykoprotein 380 19 Tetanus immunization 281,314,358 21 324 19 Tetanus immunoglobulin 324 20 Tanderil® (oxyphenbutazone) 401 19 Tetanus incidence 190,210 17 Tannic acid 70, 73 19 Tetanus incubations 195,213 22 Tapazole® (methimazole) 77 19 Tetanus infection 269,324 16 Tapeworm 164 19 Tetanus injury 213 17 Tapeworm 154 19 Tetanus intoxication 396 18 Tapeworm 191 19 Tetanus investigations 314 20 Tapeworm infections 447 19 Tetanus light effect 202,221 20 Taractan® (chlorprothixen) 389 19 Tetanus mortality 191,440 17 Tartar emetic (antimony potassium tar• 19 Tetanus neonatorum 190 trate) 111 19 Tetanus nursing 382 18 Tartar emetic (antimony potassium tar• 19 Tetanus onset 197,215 trate) 303 19 Tetanus pathogenesis 301,306 22 Tartar emetic (antimony potassium tar- 19 Tetanus prevention 391 trate) 47 19 Tetanus prognosis 214 16 Taurocyanin-Kinase 392 19 Tetanus prophylaxis 378 20 Tavegyl® (clemastine) 424 19 Tetanus recurrence 223 23 Taxol 81 19 Tetanus relapse 223 22 Tb VI (Solvoteben®) 34 19 Tetanus rigidity 200, 220 16 TBZ (Thiabendazole) 158-160 19 Tetanus severity 191 22 Tebrazid® (pyrazinamide) 36 19 Tetanus sex incidence 192 22 Tebrophen 302 19 Tetanus situation 368 22 Tegopen® (cloxacillin) 50 19 Tetanus spasms 198,217 20 Tegretol® (carbamazepine) 394 19 Tetanus symptoms 214 280 Index Vol. 16-23

19 Tetanus, therapeutic measurement 323 17 - 125,155,159, 160, 163-165, 169, 171, 19 Tetanus therapy 204,224,315 174, 176-178 19 Tetanus toxaemia 250 19 - 33, 141, 166 19 Tetanus toxin 301,316, 329, 384, 387 20 - 349,354 19 Tetanus treatment 378 22 - 49 19 Tetanus vaccination 396 16 I-Tetramisole (levamisole) 166 19 Tetanus vaccines 229 17 1-Tetramisole (levamisole) 125 16 Tetrabenazine 345 19 1-Tetramisole (levamisole) 166 17 3,3',5,5'-Tetrabromo-2,2'-biphenyldiol 20 I-Tetramisole (levamisole) 349,354 mono (dihydrogen phosphate) (bromofen• 17 Tetranorprostaglandin BI 452 fos, Acedist®, Ph 1882) 113, 134, 278 17 Tetranorprostaglandin EI 452 17 75 17 Tetranor-prostan-I,16-dioic acid 420 17 Tetracap® (tetrachlorethylene) 130 22 Tetrazepam (Myolastan®) 250 17 Tetrachlorethylene (tetrachloroethylene, 17 41 Ankilostin®, Nema®, Tetracap®) 130, 138, 22 Thalamontal® (fentanyl + droperidol) 185 162 16 99 19 - 36,40,70,72,86,92, 103, 154 21 Thalidomide 199,242 20 - 451 17 Thaurocholate 94 22 - 46 20 51,53 17 N-[I, 1,2,2-Tetrachloro-2-fluoroethyl)• 22 Thebaine 151 thio )alkanesulphonanilides 308 20 Thelazia 350 17 4,5,6,7-Tetrachloro-2-(trifluoromethyl)- 17 Thelazia gulosa 171 benzimidazole 291 17 Thelazia rhodesi 171 16 Tetracosanoic acid 284 17 Thelmesan® (dymanthine) 131 17 Tetracycline (Achromycin®) 211,216 19 Thelmesan® (dymanthine) 103 18 - 361 20 Thenaldine (Sandosten®) 426 19 - 510,519,539,568 17 Theniathane® (dichlorophene) 121 20 - 436,440 17 Thenium (Ancaris®, Bancaris®, Cano- 21 - 170 par®) 130, 162 22 - 53, 132 20 Tenormin® (atenolol) 411 17 14C_ Tetracycline 230 16 2-(2-Thenyithio)-2-imidazoline 166 17 activities 223 19 Theophylline 521 17 Tetracyclines biology 234 20 Thephorin® (penindamine) 426 17 Tetracyclines biosynthesis 230 20 Therapeutic activity 14 17 Tetracyclines isolation 229 20 Therapeutic trials lSI 17 Tetracyclines manufacture 228 20 Therapy fractionation 534 17 Tetracyclines purification 229 16 Thetin-Homocystein-Methylferase 404 17 Tetracyclines semisynthetic modifica- 17 Thiaben® (thiabendazole) 125 tions 213 16 Thiabendazole (Lombristop®, Mintezol®, 17 Tetracyclines total synthesis 222 Thiaben®) 158-160 16 Tetradecanoic acid 244,267 17 - 125, 133, 156, 159, 160, 163, 164, 166, 23 Tetradecanoyl phorbol acetate (TPA) 72 169,172,174,176,177, 179, 184, 185 16 213 18 - 199,202 20 Tetraethylammonium chloride 200, 409 19 - 33,36,41,42,152,166 20 1,2,4,5-Tetrahydro-3H,3-benzazepines 72 20 - 452 18 5,6,7,8-Tetrahydrobiopterin 300 22 - 49, 109, 119 16 LJ8_ Tetrahydrocannabinol 224 17 Thiacetarsamide (arsenamide, Caparside®, 16 LJ9_ Tetrahydrocannabinol 224 Caparsolate®) 122 20 Tetrahydrofolic acid 471 18 Thiacetazone (Conteben®) 212 17 L( - )-Tetrahydrofolic acid 324 22 - 34 16 p-Tetrahydronaphthylamine 337 22 Thiambutosine (CIBA 1906®) 36 16 Tetrahydroquinolines 58 20 Thiamenidine 223 17 Tetrahydro-2H-I,3,5-thiadiazine-2- 22 Thiamine (vitamin BI) 86 thiones 290 23 Thiamine (vitamin BI) 51 17 Tetrahydrothiophene-3-o1 I, I-dioxide 366 22 Thiamphenicol (Glitisol®) 54 17 Tetrahydrouridine 333 22 Thiamycin 53 16 2,2,17,17-Tetramethyloctadecane-I, 18- 23 Thiamycin 54 dioic acid 237 17 S-2-{[2-(2-Thiazolylcarbamoyl)-ethyl)ami- 16 2,2,17, 17-Tetramethyloctadecanoic no}ethyl hydrogen thiosulphate 266 acid 237 16 Thiazothielite 163, 164 16 Tetramisole (Ascarotrat®, Nilverm®, 16 Thiazothienol 163 Ripercol®) 158, 161, 162 22 Thieno-I,4-benzodiazepinones 256 Index Vol. 16-23 281

21 Thieno[2,3-b]pyridines 90 23 Thyrotropin releasing hormone (TRH) 58, 16 P-2-Thienyl-alanine 88 59 16 2-[2-(2-Thienyl)ethyl]-2-imidazoline 166 19 Thyroxine 267 23 Thin-layer chromatography 122 22 Thyroxine 77 17 2,2'-Thio bis( 4, 6-dichlorophenol) (bithio• 23 Thyroxine 38 nol) 278 17 Thysanosoma actinioides 154 17 Thio-3,5-bis(trifiuoromethyl) carbani- 20 244, 417 lides 307 17 Tiguvon® (fenthion) 128 22 Thiocarlide (Isoxyl®) 36 22 207 16 Thiocymetin 118 22 Tilorone 63 16 Thiogalaktosid-Transacetylase 390 20 Timolol (Blocadren®) 34,36,226,229,230, 16 6-Thioguanine (6-TG) 75,94 411 17 6-Thioguanine (6-TG) 336,341,342 22 Tinactin® (tolnaftate) 36 20 6-Thioguanine (6-TG) 473 20 Tinidazole (Fasigyne®) 438 17 6-Thioguanylic acid 341 22 - 46 17 6-Thioinosine 339, 342 20 33, 227 17 6-Thioinosinic acid 337, 340 21 Tissues regitries 255 20 Thiopental (Pentothal®) 387 17 Tixantone® (lucanthone) 115 21 - 109 22 Tobramycin (Nebcin®) 56 16 Thioproperazine 346 22 a-Tocopherol (vitamin E) 86 16 Thioredoxin-Reductase 390 19 Toes, hyperfiexion of 221 20 Thioridazine (Melleri1®) 389 20 Tofranil® () 394 21 - 357,413 20 34, 36, 229 16 Thiosemicarbazide 220 22 (Tolinase®) 81 22 Thiosemicarbazones 284 20 Tolazoline (Priscol®) 220, 413 17 Thiosinamine (allylthiourea) 274 22 Tolbutamide (Rastinon®, Orinase®) 80 16 Thiosulfat-Sulfurtransferase 388 23 - 38 16 Thio-TEPA [triethylenethiophosphor• 17 Tolene® (ronnel) 128 amide, tris(l-aziridinyl)phosphine 22 Tolinase® (tolazamide) 81 sulfide] 118 20 226 17 Thio-TEPA [triethylenethiophosphor• 22 Tolnaftate (Tinactin®) 36, 126 amide, tris(1-aziridinyl)phosphine 22 Topisolon® (desoxymethasone) 74 sulfide] 363 16 Torulopsis apicola 266,274 20 Thio-TEPA [triethylenethiophosphor• 16 Torulopsis gropengiesseri 265,270,275 amide, tris(l-aziridinyl)phosphine 16 Torulopsis magnolia 264 sulfide] 468 19 Toxaemia 416 22 Thio-TEPA [triethylenethiophosphor• 17 Toxascaris canis 156 amide, tris(1-aziridinyl)phosphine 17 Toxascaris leonina 156 sulfide] 64 21 Toxic dose 132 22 Thiourea 77 21 Toxicity 126, 163, 192 176-Thiouric acid 340 21 Toxicity dose dependency 140,200 21 cis- 417 20 Toxicity test 18 21 Thioxanthene derivatives 441 16 Toxicology 199 16 Thioxanthenones 40-46 20 Toxicology 146 17 6-Thioxanthine 339 .21 Toxicology 124, 163 17 6-Thioxanthylic acid 339 19 Toxin 249 16 Threonin-Dehydratase 402,404 19 Toxin activation 566 16 Thrombin 388 19 Toxin binding 566 21 Thrombo-embolism 244 19 Toxin elaboration 565 17 Thrombosis, prevention of 466 16 Toxin A 376 17 Thyasanieza ovilla 297 16 Toxin B 376 16 Thymectomy 78 17 Toxocara canis 184 16 Thymidylat-Synthetase 390 20 Toxocara canis 455 20 Thymidylic acid 471 17 Toxocara cati 184 22 128 19 Toxocara cati 54 16 Thymostatin 112 20 Toxocara infection 354 22 Thymoxamine 368 19 Toxoid lot No.OOIOI 544 20 Thymoxyethyl-diethylamine 424 19 Toxoid preparations 265 16 Thyreoglobulin 382 23 Toxoids II 16 Thyreotropes Hormon 374 18 Toxoplasma gondii 205 23 L-Thyronine derivatives 147 20 Toxoplasma gondii 437 282 Index Vol. 16-23

18 , diagnosis of 210 19 Trichlorophenol-piperazine 33 16 TPN +-Isocitrat-Dehydrogenase 394 17 5-(2,4,5-Trichlorophenyl)-hydantoin 270 16 TPNH-Cytochrom-C-Reductase 392 18 Trichlorotriftuoroethane 375 22 Trace® (chlorotrianisene) 72 17 Trichomonas vaginalis 263 19 Tracheostomy 246, 298 20 Trichomonas vaginalis 442 16 Transaldolase 390 20 Trichomonal vaginitis 442 16 Transcarboxylase 418 17 Trichostrongyliasis 164 19 Transferrin 110,551 18 Trichostrongylus 194 16 Transketolase 400 16 Trichostrongylus colubriformis 161 22 Tranxene® (clorazepate) 245 17 Trichostrongylus colubriformis 164 20 Tranylcypromine (Pamate®) 396 17 Trichuriasis 174 20 Trasentine® (adiphenine) 420 18 Trichuriasis 192 20 Trasicor® (oxprenolol) 411 19 Trichuriasis 14,23,34, 170 16 Trasylol 112 20 Trichuriasis 452 20 Trausabun® (melitracen) 394 20 Trichuris 355 22 Trecator-SC® (ethionamide) 36 17 Trichuris suis 174 17 Trematodes III 16 Trichuris trichiuria 165 17 Tremerad® (clioxanide) 114,281 17 Trichuris trichiuria 174 16 342 18 Trichuris trichiuria 191 20 Tremor 38 19 Trichuris trichiuria 15,29,34,81, 102, 106, 16 Tremorine 350 141,161 22 Trenimon® (triaziquone) 64 20 Trichuris trichiuria 452 18 Treptonematosis 280 16 Trichuris vulpis 173 23 TRH (thyrotropin releasing hormone) 58, 17 Trichuris vulpis 174 59 17 Triclofenol piperazine (Ranestol®) 127, 22 Triamcinolone (Aristocort®, Kenacort®, 161 Ledercort®) 75 22 Triclosan (lrgasan DP3OO®) 29 18 2,4,6-Triaminoquinazolines 116 16 Tridecylen 234 20 Triamterene (Dyrenium®) 213,417 23 Tridixethyl n-aikyisulfonates 118 20 Triazenoimidazoles 469 17 Triethylenemelamine 361 22 Triazino[5,6-bJindoles 285 20 Triethylenemelamine 468 22 Triaziquone (Trenimon®) 64 22 Triethylenemelamine 64 20 Triazolam (Halicon®) 393 16 Triethylen thio-phosphoramide (Thio- 22 - 254,255,367 TEPA) 118 16 1,2,4-Triazole 278 17 Triftocin 67 22 Triazure® (azaribine) 64 22 Triftubazam 257 21 Tribolium castaneum 179 17 I, I, I-Triftuoro-2-chloro-2-bromoethane 17 3,4,5-Tribromosalicylamide 284 (halothane) 16 16 Tricaprin 234 22 Triftuorothymidine 295 16 Tricaprylin 234 17 Triftuperazine 75 17 Trichazol® (metronidazole) 125 18 Triftuperidol 437 17 Trichinelliasis 185 17 Triglyceride lipase 467 16 Trichinosis 160 17 9a, Ila, 15-Trihydroxyprost-5-enoic 20 Trichinosis 454 acid 453 18 Trichinella spiralis 195 17 2-(2,4,6-Triiodophenoxy)butyric acid 20 Trichinella spiralis 454 (phenobutiodil, Trijobil®) 299 20 Trichlorethanol 387 22 Triiodoresorcinol 302 20 210 19 Triiodothyronine 245 18 I, 1,1-Trichloro-2,2-bis(p-chlorophenyl) 22 Triiodothyronine 77 ethane (DDT) 248,267,284 23 Triiodothyronine 39 18 Trichloroethane 376 17 Trijobil [2-(2,4,6-triiodophenoxy)butyric 17 I, I , I-Trichloroethane 16 acid, phenobutiodilJ 299 17 I, 1,2-Trichloroethane 16 16 Trilaurin 234 17 6,6'-(2,2,2-Trichloroethylidene)dithy• 20 234 mol 296 20 Trimethaphan 202 18 Trichloroftuoromethane 370 20 Trimethaphan camsylate (Arfonad®) 409 16 Trichlorofon (metrionate, trichlorophon, 20 Trimethidinium 202 Negaron®, Dipterex®) 168 16 Trimethoprim (Syraprim®) 91 17 - 128,143,158,164,170,171,175,183,268 18 - 108,116 22 - 47 20 - 435,436 20 Trichlorophen 447 22 - 31,44 Index Vol. 16-23 283

23 1,2,3-Trimethoxybenzene 108 19 d-Tubocurarin 149,296 23 2,2,3-Trimethylbutane 127 16 376,430 16 3,9,9-Trimethyldecanoic acid 287 19 Tularemia 280 21 Trimethylphosphate 189 20 Tumor 357, 358, 526 16 Trinonylin 234 20 Tumor overacidification 550 16 Triosephosphat-Isomerase 388 23 Tumor promoters 65 17 Triostam® (antimony sodium gluco- 16 Turnip-yellow-Virus 384 nate) Ill, 140 17 TWSb/6 (stibocaptate) 112 20 Triparanol 418 18 Tylosin 422 23 Tripdiolide 83 23 Type-specific immunity 13 20 Tripelennamine (Pyribenzamine®) 426 23 Typhoid 15 19 Triple Antigen Glaxo 231, 253 19 Typhoid vaccines 275,277 17 Tris(p-aminophenyl)carbonium 255 23 Typhoid vaccines 14 16 Triundecylen 234 19 Tyramine 149 22 Trobicin® (spectinomycin) 56 16 Tyrosin-Aminotransferase 398 17 Trodax® (nitroxynil) 117,278 16 Tyrosinase 398 22 Tromantadine 279 21 Tyrosine 411 17 Tropical diseases 110 16 337,344 18 Tropical medicine 35 21 Tyrosine hydroxylase 412 18 Tropical medicine, teaching of 35 16 Tyrosinreste 367 16 Tropocollagen 378 16 Tropomyosin B 376 U 22 Trypaflavine 38 23 Ubiquinone (conenzyme Q) 54 19 Trypan blue 505 16 UDPgalaktose 4-Epimerase 392,410 21 Trypan blue 38 16 UDPglucose-Pyrophosphorylase 414 22 Trypan red 38 17 UK 3883 (2-[(isopropylamino)methyl)-6- 18 Trypanomycin 331 methyl-7-nitro-l,2,3,4-tetrahydroquino• 18 Trypanosoma brucei 302 line) 253 18 Trypanosoma cruzi 111,323 17 UK 4271 (oxamniquine) 253 20 Trypanosoma cruzi 446 22 Ultandren® (floxymesterone) 69 23 Trypanosoma cruzi 15 17 Ultracentrifugation 493 19 Trypanosoma equiperdum 519 22 Ultralan® (fluocortolone 21-caproate) 74 18 Trypanosoma evansi 302 17 Ultramicroelectrodes 39 20 Trypanosoma gambiense 445 16 Ultrazentrifugenmethoden 272 20 Trypanosoma rhodesiense 445 17 Uncinaria stenocephala 163 22 Tryparosan 38 16 Undecane-I, ll-dioic acid 233 22 Tryparsamide (Trypotanide®) 40 22 Undecenoic acid 130 22 Trypotanide® (tryparsamide) 40 16 Undec-lO-enoic acid 240 16 Trypsin 112,338 22 Uracil Mustard 64 17 Trypsin 81 22 Urbanyl® (clobazam) 258 20 Trypsin 79,332 22 Urbason® (methylprednisolone) 74 16 Tryptophan 221 17 Urea 71 21 Tryptophan 314 16 Urease 416 16 L-Tryptophan 341 18 Urea stibamine (Stiburea®) 310,314 22 L-Tryptophan 369 20 - 442 16 Tryptophanase 408 21 Urinary tract infections 11 16 Tryptophan-Oxigenase 398 19 Urine retention 221 16 Tryptophan-Synthetase 394,400,402 16 Urocanase 398 16 Tryptophanyl-tRNA-Synthetase 396,434 22 Urotropin® (methenamine) 29 17 Tubercidin 271 20 Urticaria 589 18 Tubercle bacillus 96,214 23 L-U snic acid 83 18 Tuberculin test 98 17 Uterus 454 18 Tuberculosis 28,44,279 19 Tuberculosis 256 V 23 Tuberculosis 22 18 Vaccination 255,285 18 Tuberculosis control 93 20 Vaccination 574 18 Tuberculosis control programme 97 18 Vaccines 256 19 Tuberculosis vaccine 274 19 Vaccines 274 18 Tuberculosis therapy 212 23 Vaccines I 1 20 Tubocurarin 335,421 19 Vaccines, field trials 481 21 Tubocurarin III 19 Vaccines, problems 235 284 Index Vol. 16-23

19 Vaccines, production 229 19 Vibrio 598 19 Vaccines, testing 233 19 Vibrio parahaemolyticus 490,516,586 17 Valinomycin 67 19 Vibrio parahaemolyticus carriers 500 19 Valium® (diazepam) 439 19 Vibrio parahaemolyticus identification 588 20 Valium® (diazepam) 393,422 19 Vibrio parahaemolyticus isolation 587 22 Valiumll (diazepam) 230,242 19 Vibrio parahaemolyticus strains 588 20 Vallene® 409 19 Vibrios cholera binding 565 20 Valmidll (ethinamate) 387 19 Vibriostatic drug 519 17 Valynomycetin 69 22 Vidarabine (Vira-A®) 61 16 Vancomycin 313,318 20 Viloxazine (Vivalanll) 396 19 245 22 - 365 19 Varicella-zoster 281 22 205 20 Vasculat® (bamethan) 411 16 Vinblastine (Velbanll) 85,86 20 Vasodilators 232 17 - 380 20 Vasopressin 286 18 - 414 20 Vatensol11 (guanoclor) 410 20 - 473,585 19 Vegetative nervous system 305 22 - 64 21 Vein thrombosis 315 20 Vinca alkaloids 473 22 Velban® (vinblastine) 64 18 Vincoridine 409 18 Velbanamine 413 16 Vincristine (Oncovinll) 85 22 Velosef4l> (cephradine) 53 17 - 370,380 23 Veneral disease 19 18 - 413 20 Ventolin® (salbutamol) 419 20 - 473 17 Verapamil (Isoptinll) 46,52 22 - 64 20 - 406 18 Vindorosine 411 16 Veratrine 213 18 Vinkaleukoblastine 412 17 Veratrine 35,75 18 Vinrosamine 413 20 Vergolysen® (hexamethonium chlo- 18 Vinyl chloride 389 ride) 409 22 Viocin® (viomycin) 59 18 Vermiculine 331 22 Vioform® (clioquinol) 42 23 Vermiculine 78 18 Viomycin (Viocinll, Vionactan®) 212 22 Verminumll (parbendazole) 49 22 - 59 17 Vermiplex® (dichlorophene) 121 22 Vionactan® (viomycin) 59 17 Vermitinll (phenothiazine) 131 22 Vira-A® (vidarabine) 61 20 Vermox® (mebendazole) 452 20 Viral infection 355 22 Vermox® (mebendazole) 49 22 Virazolell (ribavirin) 61,290 23 Vemolepin 78 22 Virazole analogues 291 22 Versicolin 131 19 Virulence test 547 22 Verstranll (prazepam) 261 22 Virus diseases 268 20 Veterinary drugs 17 20 Visceral larval migrans 455 17 Viaseptll (glycobiarsol) 123 20 Visceral Leishmaniasis (Kala Azar) 442 22 Vibramycin® (doxycycline) 53 19 Visceral organs 306 19 Vibrio alginolyticus 516 20 Visken® (pindolol) 36,411 19 Vibrio cholerae 460,472,482,491,503,546, 17 Vitamin A (retinol) 75 612 22 Vitamin A (retinol) 84 19 Vibrio cholerae antigen 612 20 Vitamin A glucuronide 566 19 Vibrio cholerae genetic recombination 460 22 Vitamin BI (thiamine) 86 19 Vibrio cholerae hybrides 461 18 Vitamin B2 (riboflavine) 431 19 Vibrio cholerae identification 515 22 Vitamin B2 (riboflavine) 86 19 Vibrio cholerae Inaba antiserum 468 22 Vitamin B6 (pyridoxine) 86 19 Vibrio cholerae Inaba vaccine 544 19 Vitamin BI2 108,330 19 Vibrio cholerae Inaba 569B 504 22 Vitamin C (ascorbic acid) 84,85 19 Vibrio cholerae isolation 515,579 22 Vitamin D 84 19 Vibrio cholerae phage types 583 22 Vitamin D3 (cholecalciferol) 86 19 Vibrio cholerae strains 461, 547, 581, 597, 23 Vitamin BI2 51 600 22 Vitamin E (a-tocopherol) 86 19 Vibriocidal antibody 475,556, 560, 605 22 Vitamin H (biotin) 86 19 Vibriocidal antibody titer 608 22 Vitamin K 86 19 Vibriocidal titers 543,605 22 Vitamin KI (phylloquinone) 85 19 Vibrio costicolus 516 18 Vitamins 431 19 Vibrio El Tor 461,466,504,507 23 Vitamins 51 Index Vol. 16-23 285

20 Vivalan® (viloxazine) 396 18 Wuchereria bancrofti 142, 174,201,260, 20 Voltaren® ( sodium) 401 271 20 Wuchereria bancrofti 455 W 16 Wachstumsfaktor, epidermaler 376 X 17 Warfarin (Coumadin®) 495 17 Xenobiotic detoxification 488 20 - 404 16 X-Irradiation 79 21 - 117 20 244 19 Water examination 583 16 X-Rays 103 19 Waterloss 530 17 X-Rays 74 19 Water supply 571 20 223 16 Weinsiiure-Dehydratase 400 23 p-Xylene 133 16 Whipvvorm 160, 163 17 Xylocaine® (lidocaine) 75 18 Whipvvorm 191 20 Xylocaine® (lidocaine) 403 19 Whipvvorm 170 17 9-P-o-Xylofuranosyladenine 346 19 Whole celIe lysate toxin 472 17 9-p-n-Xylofuranosylhypoxanthine 346 19 Whooping cough 179, 256, 343, 348 20 Xylometazoline (Otrivine®) 420 23 Whooping cough 12 19 n-Xylose 46, III 19 Whooping cough incidence 258 23 n-Xylose 40 19 Whooping cough morbidity 258 19 Whooping cough mortality 258 Y 21 WIN 18446 [N,N1-bis(dichloracetyl)-1,8- 22 Yatren® (chiniofon) 42 octanediamine) 352 18 Yavv 44 22 Winstrol® (stanozol) 69 16 Yeast 264 23 Withaferin A 85 19 Yellovv fever vaccine 274 16 Worm diseases 159 17 Yomesan® () ll9,297 19 Worm-infestation 136 20 Yomesanill (niclosamide) 447 17 Worm Guard® (parbnedazole) 159 22 Yomesan® (niclosamide) 46 18 WR-81,844 (1-(3,4-dichlorophenyl)-3-{4- [( l-ethyl-3-piperidyl)amino )-6-methyl-2- Z pyrimidinyl}guanidine 140 17 Zanilill (oxyclozanide) 1I5,281 18 WR-135,403 (2,4-diamino-6-[(p-chlorophe- 22 Zepbiran chlorideill (benzalkonium chlo- nyl)thio)quinazoline) 129 ride) 29 20 WR 142.490 (metloquine) 437 16 339 22 WR 142.490 (metloquine) 42 19 Zirconyl chloride 568 18 WR-158,122 [2,4-diamino-6-(2-naphthyl• 21 Zona pelludica antigens 368 sulfonyl)quinazoline) 130 17 23 17 Wuchereria bancrofti 180 20 Zylopriro® (allopurinol) 402 287 Subject Index Sachverzeichnis Table des matieres Vol. 1-23 (1959-1979)

Acetylen-Verbindungen als Arzneistoffe, Androgenic-anabolic steroids and naturliche und synthetische , interactions 14,387 (1970) 14, 139 (1970) p-Adrenergic blocking agents Anthelmintic action, mechanisms of 20,27 (1976) 19, 147(1975) p-Adrenergic blocking agents, Anthelminticaforschung, neuere Aspekte pharmacology and structure-activity 1,243 (1959) 10,46 (1966) , comparative efficacy p-Adrenergic blocking drugs, 19, 166 (1975) pharmacology Anthelmintics, laboratory methods in the 15, 103 (1971) screening of Adverse reactions of sugar polymers in 19, 48 (1975) animals and man Anthelmintics, structure-activity 23,27 (1979) 3, 75 (1961) , pharmacological approach Anthelmintics, human and veterinary 3,409 (1961) 17, llO (1973) Amebic disease, pathogenesis of Antiarrhythmic compounds 18,225 (1974) 12,292 (1968) Amidinstruktur in der Antiarrhythmic drugs, recent advances in Arzneistofforschung electrophysiology of 11,356 (1968) 17,34 (1973) Amino- und Nitroderivate (aromatische), Antibacterial agents of the nalidixic acid biologische Oxydation und Reduktion type 8, 195 (1965) 21,9(1977) Aminonucleosid-Nephrose Antibiotics, structure and biogenesis 7,341 (1964) 2,591 (1960) Amoebiasis, chemotherapy Antibiotika, krebswirksame 8, 11 (1965) 3,451 (1961) Amoebiasis, surgical Antibody titres, relationship to resistance 18,77 (1974) to experimental human infection Amoebicidal drugs, comparative 19,542 (1975) evaluation of Anticancer agents, metabolism of 18,353 (1974) 17,320 (1973) Anabolic steroids Antifertility substances, development 2, 71 (1960) 7, 133 (1964) Analgesia and addiction Anti-filariasis campaign: its history and 5, 155 (1963) future prospects Analgesics and their antagonists 18,259 (1974) 22, 149 (1978) Antifungal agents Ancylostomiasis in children, trial of 22,93 (1978) bitoscanate Antihypertensive agents 19,2(1975) 4,295 (1962), 13, lOl (1969) 288 Index Vol. 1-23

Antihypertensive agents Bitoscanate, clinical experience 20, 197 (1976) 19, 96 (1975) Antiinflammatory agents, nonsteroid Bitoscanate, experience in the treatment 10, 139 (1966) of adults Antiinflammatory drugs, biochemical 19,90 (1975) and pharmacological properties 8,321 (1965) Cancer chemotherapy Antikoagulantien, orale 8,431 (1965),20,465 (1976) 11,226 (1968) Cancerostatic drugs Antimetabolites, revolution in 20,521 (1976) pharmacology Carcinogens, molecular geometry and 2, 613 (1960) mechanism of action Antituberculous compounds with special 4, 407 (1962) reference to the effect of combined Central dopamine receptors, agents treatment, experimental evaluation of acting on 18, 2II (1974) 21,409 (1977) Antiviral agents Central nervous system drugs, 22,267 (1978) biochemical effects Art and science of contemporary drug 8, 53 (1965) development Chemotherapy of schistosomiasis, recent 16, 194 (1972) developments Arzneimittel, neue 16, II (1972) 1,531 (1959),2,251 (1960), 3, 369 Cholera infection (experimental) and (1961),6,347 (1963),10,360 (1966) local immunity Arzneimittel, Wert urid Bewertung 19,471 (1975) 10, 90 (1966) Cholera in Hyderabad, epidemiology of Arzneimittelwirkung, Eintluss der 19,578 (1975) Formgebung Cholera in Don-endemic regions 10,204 (1966) 19, 594 (1975) Arzneimittelwirkung, galenische Cholera, pandemic, and bacteriology Formgebung 19,513 (1975) 14,269 (1970) Cholera pathophysiology and Atherosclerosis, cholesterol and its therapeutics, advances relation to 19, 563 (1975) 1, 127 (1959) Cholera, researches in India on the Ayurvedic medicine control and treatment of 15, II (1971) 19, 503 (1975) Cholera toxin induced fluid, effect of Basic research, in the US pharmaceutical drugs on industry 19,519 (1975) 15,204 (1971) Cholera toxoid research in the United Benzodiazepine story States 22,229 (1978) 19,602 (1975) Bewertung eines neuen Antibiotikums Cholera vaccines in volunteers, antibody 22,327 (1978) response to Biochemical acyl hydroxylations 19, 554 (1975) 16,229 (1972) Cholera vibrios, interbiotype conversions Biological activity, stereochemical factors by actions of mutagens 1,455 (1959) 19,466 (1975) Biological response quantification in Cholesterol, relation to atherosclerosis toxicology, pharmacology and 1. 127 (1959) Cholinergic mechanism-monoamines 21, 105 (1977) relation in certain brain structures Bitoscanate, a field trial in India 6,334 (1972) 19,81 (1975) Index Vol. 1-23 289

Clostridium tetani, growth in vivo Drug in biological cells 19, 384 (1975) 20,261 (1976) Communicable diseases, some often Drug latentiation neglected factors in the control and 4,221 (1962) prevention of Drug-macromolecular interactions, 18,277 (1974) implications for pharmacological activity Contraception 14, 59 (1970) 21,293 (1977) Drug metabolism compounds 13, 136 (1969) 15,227 (1971) Drug metabolism (microsomal), enhancement and inhibition of Deworming of preschool community in 17, 12 (1973) national nutrition programmes Drug potency 19, 136 (1975) 15, 123 (1971) Diarrhoea (acute) in children, Drug research management of 10, 11 (1966) 19, 527 (1975) Drug research and development Diarrhoeal diseases (acute) in children 20, 159 (1976) 19, 570 (1975) Drugs, biliary excretion and 3,4-Dihydroxyphenylalanine and related enterohepatic circulation compounds 9, 299 (1966) 9, 223 (1966) Diphtheria, epidemiological observations Egg-white, reactivity of rat and man in Bombay 13,340 (1969) 19,423 (1975) Endocrinology, twenty years of research Diphtheria, epidemiology of 12, l37 (1968) 19, 336 (1975) Endotoxin and the pathogenesis of fever Diphtheria in Bombay 19,402 (1975) 19,277 (1975) Enterobacterial infections, chemotherapy Diphtheria in Bombay, age profile of of 19,417 (1975) 12,370 (1968) Diphtheria in Bombay, studies on 19,241 (1975) Filarial infection, immuno-diagnosis Diphtheria, pertussis and tetanus, clinical 19, 128 (1975) study Filariasis, chemotherapy 19, 356 (1975) 9, 191 (1966) Diphtheria, pertussis and tetanus Filariasis in India vaccines 18, 173 (1974) 19,229 (1975) Filariasis, in four villages near Bombay, Diphtheria toxin production and iron epidemiological and biochemical studies 19,283 (1975) in Disease control in Asia and Africa, 18,269 (1974) implementation of Filariasis, malaria and leprosy, new 18,43 (1974) perspectives on the chemotherapy of Diuretics 18,99 (1974) 2,9(1960) Fluor, derives organiques d'interet Drug action and assay by microbial pharmacologique kinetics 3, 9 (1961) 15,271 (1971) Fundamental structures in drug research Drug action, basic mechanisms Part I 7, 11 (1964) 20,385 (1976) Drug combination, reduction of drug Fundamental structures in drug action research Part II 14, 11 (1970) 22,27 (1978) 290 Index Vol. 1-23

Galenische Formgebung und Immunization of a village, a new Arzneimittelwirkung approach to herd immunity 10, 204 (1966), 14. 269 (1970) 19,252 (1975) Ganglienblocker Immunization, progress in 2,297 (1960) 19,274 (1975) Immunology Heilmittel, Entwicklung 20, 573 (1976) 10,33 (1966) Immunosuppression agents, procedures, Helminthiasis (intestinal), chemotherapy speculations and prognosis of 16,67 (1972) 19, 158 (1975) Impact of natural product research on Helminth infections, progress in the drug discovery experimental chemotherapy of 23,51 (1979) 17,241 (1973) Indole compounds Helminthic infections, immuno- 6,75 (1963) diagnosis of Indolstruktur, in Medizin und Biologie 19, 119 (1975) 2,227 (1960) Homologous series, pharmacology Industrial drug research 7,305 (1964) 20, 143 (1976) Hookworm anaemia and intestinal Influenza virus, functional significance of malabsorption the various components of 19, 108 (1975) 18,253 (1974) Hookworm disease and trichuriasis, Interaction of drug research experience with bitoscanate 20, 181 (1976) 19,23 (1975) Intestinal nematodes, chemotherapy of Hookworm disease, bitoscanate in the 16, 157 (1972) treatment of children with Ionenaustauscher, Anwendung in 19,6(1975) Pharmazie und Medizin Hookworm disease, comparative study of 1, 11 (1959) drugs Isotope, Anwendung in der 19, 70 (1975) pharmazeutischen Forschung Hookworm disease, effect on the 7,59 (1964) structure and function of the small bowel 19,44(1975) Leishmaniases Hookworm infection, a comparative 18,289 (1974) study of drugs Leprosy, some neuropathologic and 19, 86 (1975) cellular aspects of Human sleep 18,53 (1974) 22,355 (1978) Leprosy in the Indian context, some Hydatid disease practical problems of the epidemiology 19, 75 (1975) of Hydrocortisone, effects of structural 18,25 (1974) alteration on the antiinflammatory Leprosy, malaria and filariasis, new properties perspectives on the chemotherapy of 5,11(1963) 18,99 (1974) 5-Hydroxytryptamine and related Levamisole indolealkylamines 20, 347 (1976) 3, 151 (1961) Lipophilicity and drug activity Hypolipidemic agents 23,97 (1979) 13,217 (1969) Lokalanasthetika, Konstitution und Wirksamkeit Immunization, host factors in the 4, 353 (1962) response to Lysostaphin: model for a specific 19,263 (1975) enzymatic approach to infectious disease 16,309 (1972) Index Vol. 1-23 291

Malaria chemotherapy, repository Parasitosis (intestinal), analysis of antimalarial drugs symptoms and signs 13, 170 (1969) 19, 10 (1975) Malaria, eradication in India, problems Pertussis agglutinins and complement of fixing antibodies in whooping cough 18,245 (1974) 19, 178 (1975) Malaria, filariasis and leprosy, new Pertussis, diphtheria and tetanus, clinical perspectives on the chemotherapy of study 18,99 (1974) 19,356 (1975) Mass spectrometry in pharmaceutical Pertussis, diphtheria and tetanus vaccines research, recent applications of 19,229 (1975) 18,399 (1974) Pertussis, epidemiology of Medical practice and medical 19,257 (1975) pharmaceutical research Pertussis vaccine 20,491 (1976) 19,341 (1975) Medicinal chemistry, contribution to Pertussis vaccine composition medicine 19, 347 (1975) 12, 11 (1968) Pharmacology of the brain: the Medicinal science hippocampus, learning and seizures 20,9(1976) 16,211 (1972) Membrane drug receptors Phenothiazine und Azaphenothiazine 20,323 (1976) 5, 269 (1963) , and related compounds Photochemistry of drugs 11, 11 (1968) 11,48 (1968) Metabolism of drugs, enzymatic Placeboproblem mechanisms 1,279 (1959) 6, 11 (1963) Propellants, toxicity of Metabolism (oxydative) of drugs and 18,365 (1974) other foreign compounds Prostaglandins 17,488 (1973) 17,410 (1973) Metronidazol-Therapie, Trichomonasis Protozoan and helminth parasites 9,361 (1966) 20,433 (1976) Molecular pharmacology Psychopharmaka, Anwendung in der 20, 101 (1976) psychosomatischen Medizin Molecular pharmacology, basis for drug 10, 530 (1966) design Psychopharmaka, strukturelle 10,429 (1966) Betrach tungen Monitoring adverse reactions to drugs 9, 129 (1966) 21,231 (1977) Psychosomatische Medizin, Anwendung Monoaminoxydase-Hemmer von Psychopharmaka 2,417 (1960) 10, 530 (1966) agents Narcotic antagonists 15,68 (1971) 8,261 (1965),20,45 (1976) Necator american us infection, clinical Quaternary ammonium salts, chemical field trial of bitoscanate nature and pharmacological actions 19,64 (1975) 2, 135 (1960) Nematoide infections (intestinal) in Quinazolones, biological activity Latin America 14,218 (1970) 19,28 (1975) Quinuclidine derivatives, chemical structure and pharmacological activity Parasitic infections in man, recent 13, 293 (1969) advances in the treatment of 18, 191 (1974) Red blood cell membrane, as a model for targets of drug action 17, 59 (1973) 292 Index Vol. 1-23

Reproduction in women, Tetanus in children pharmacological control 19,209 (1975) 12,47 (1968) Tetanus in Punjab and the role of muscle Research, preparing the ground: relaxants importance of data 19,288 (1975) 18,239 (1974) Tetanus, mode of death Rheumatherapie, Synopsis 19,439 (1975) 12, 165 (1968) Tetanus neonatorum 19, 189 (1975) Schistosomiasis, recent progress in the Tetanus, pertussis and diphtheria chemotherapy of vaccines 18, 15 (1974) 19,229 (1975) Schwefelverbindungen, therapeutisch Tetanus, present data on the verwendbare pathogenesis of 4,9(1962) 19, 301 (1975) Shock, medical interpretation Tetanus, role of beta-adrenergic blocking 14, 196 (1970) drug propranolol Social pharmacology 19, 361 (1975) 22,9(1978) Tetanus, situational clinical trials and Spectrofluorometry, physicochemical therapeutics methods in pharmaceutical chemistry 19,367 (1975) 6, 151 (1963) Tetanus, therapeutic measurement Stoffwechsel von Arzneimitteln, Ursache 19,323 (1975) von Wirkung, Nebenwirkung und Tetracyclines Toxizitiit 17,210(1973) 15, 147 (1971) Thymoleptika, Biochemie und Strahlenempfindlichkeit von Pharmakologie Siiugetieren, Beeinflussung durch 11, 121 (1968) chemische Substanzen Toxoplasmosis 9,11(1966) 18,205 (1974) Structure-activity relationships Trichomonasis, Metronidazol-Therapie 23, 199 (1979) 9, 361 (1966) Substruktur der Proteine, tabellarische Trichuriasis and hookworm disease in Zusammenstellung Mexico, experience with bitoscanate 16,364 (1972) 19, 23 (1975) Sulfonamide research Tropical medicine, teaching 12, 389 (1968) 18,35 (1974) Tuberculosis in rural areas of , biological activity Maharashtra, profile of 6,279 (1963),13, 11 (1969) 18,91 (1974) Tetanus and its prevention Tuberkulose, antibakterielle 19, 391 (1975) Chemotherapie Tetanus, autonomic dysfunction as a 7, 193 (1964) problem in the treatment of Tumor promoters and antitumor agents 19,245 (1975) 23,63 (1979) Tetanus, cephalic 19,443 (1975) Unsolved problems with vaccines Tetanus, cholinesterase restoring therapy 23,9(1979) 19, 329 (1975) Tetanus, diphtheria and pertussis, Vaccines, controlled field trials of clinical study 19,481 (1975) 19, 356 (1975) Vibrio cholerae, cell-wall antigens of Tetanus, general and pathophysiological 19,612 (1975) aspects 19,314 (1975) Index Vol. 1-23 293

Vibrio cholerae, recent studies on genetic Vibrio parahaemolyticus infection in recombination Calcutta 19,460 (1975) 19,490 (1975) Vibrio cholerae, virulence-enhancing effect of ferric ammonium citrate on Wurmkrankheiten, Chemotherapie 19,546 (1975) 1, 159 (1959) Vibrio parahaemolyticus in Bombay 19,586 (1975) 295 Author and Paper Index Autoren- und Artikelindex Index des auteurs et des articles Vol. 1-23 (1959-1979)

Pertussis agglutinins and Dr. K. C. Agarwal complement fixing antibodies Dr. M. Ray in whooping cough Dr. N.L. Chitkara 19,178(1975) Department of Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India Pharmacology of clinically useful Prof. Dr. R.P. Ahlquist beta-adrenergic blocking drugs Professor of Pharmacology, School of 15, 103 (1971) Medicine, Medical College of , Augusta, Georgia, USA Dr. A. M. Karow, Jr. Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA Dr. M.W. Riley Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA Adrenergic beta blocking agents Prof. Dr. R. P. Ahlquist 20,27 (1976) Professor of Pharmacology, Medical College of Georgia, Augusta, Georgia, USA Trial of a new anthelmintic Dr. S. H. Ahmed (bitoscanate) in ankylostomiasis Dr. S. Vaishnava in children Department of Paediatrics, 19,2(1975) Safdarjung Hospital, New Delhi, India

Development of antibacterial Dr. R. Albrecht agents of the nalidixic acid type Department of Drug Research, 21,9(1977) Schering AG, Berlin Biological activity in the Dr. A.H. Amin quinazolone series Director of Research, Alembic Chemical 14,218 (1970) Works Co. Ltd., Alembic Road, Baroda 3, India Dr. D.R. Mehta Dr. S. S. Samarth Research Division, Alembic Chemical Works Co. Ltd., Alembic Road, Baroda 3, India 296 Index Vol. 1-23

Enhancement and inhibition of Prof. Dr. M. W. Anders microsomal drug metabolism Department of Pharmacology, University of 17, 11(1973) Minnesota, Minneapolis, Minnesota, USA Reactivity of rat and man Dr. S. I. Ankier to egg-white Allen & Hanburys Ltd., Research Division, 13, 340 (1969) Ware, Hertfordshire, England Narcotic antagonists Dr. S. Archer 8,261 (1965) Assistant Director of Chemical Research, Sterling-Winthrop Research Institute, Rensselaer, New York, USA Dr. L. S. Harris Section Head in Pharmacology, Sterling• Winthrop Research Institute, Rensselaer, New York, USA Recent developments in the Dr. S. Archer chemotherapy of schistosomiasis Associate Director of Research, Sterling• 16, 11 (1972) Winthrop Research Institute, Rensselaer, New York, USA Dr. A. Yarinsky Sterling-Winthrop Research Institute, Rensselaer, New York, USA Recent progress in the Prof. Dr. S. Archer chemotherapy of schistosomiasis Professor of Medicinal Chemistry, School of 18, 15 (1974) Science, Department of Chemistry, Rensselaer Polytechnic Institute. Troy, N. Y. 12181, USA Recent progress in research Prof. Dr. S. Archer on narcotic antagonists Professor of Medicinal Chemistry, School of 20,45 (1976) Science, Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York, USA Dr. W. F. Michne Sterling-Winthrop Research Institute, Rensselaer, New York, USA Molecular geometry and Prof. Dr. J.e. Arcos mechanism of action of chemical Department of Medicine and Biochemistry, carcinogens Tulane University, U. S. Public Health 4, 407 (1962) Service, New Orleans, Louisiana, USA Molecular pharmacology, a basis Prof. Dr. E. J. Ariens for drug design 10, 429 (1966) Institute of Pharmacology, University of Reduction of drug action by drug Nijmegen, Nijmegen, The Netherlands combination 14, 11 (1970) Index Vol. 1-23 297

Stereoselectivity and affinity Prof. Dr. E.J. Ariens in molecular pharmacology Dr. J.F. Rodrigues de Miranda 20, 101 (1976) Pharmacological Institute, University of Nijmegen, Nijmegen, The Netherlands Prof. Dr. P.A. Lehmann F. Departamento de Farmacologia y Toxicologia, Centro de Investigacion y Estudios Avanzados, Instituto Politecnico Nacional, Mexico D.F., Mexico Tetanus neonatorum Dr. V.B. Athavale 19, 189 (1975) Dr. P.N. Pai Tetanus in children Dr. A. F emandez 19,209 (1975) Dr. P.N. Patnekar Dr. Y. S. Acharya Department of Pediatrics, L. T. M. G. Hospital, Sion, Bombay 22, India Toxicity of propellants Prof. Dr. D.M. Aviado 18,365 (1974) Professor of Pharmacology, Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, USA Neuere Aspekte der chemischen Dr. J. Bally Anthelminticaforschung Wissenschaftlicher Mitarbeiter der SandozAG, 1, 243 (1959) Basel, Schweiz Problems in preparation, Dr. D.D. Banker testing and use of diphtheria, Chief Bacteriologist, pertussis and tetanus vaccines Glaxo Laboratories (India) Ltd., 19, 229 (1975) Bombay 25, India Recent advances in Prof. Dr. A. L. Bassett and Dr. A. L. Wit electrophysiology College of Physicians and Surgeons of of antiarrhythmic drugs Columbia University, Department of 17,33 (1973) Pharmacology, New York, N. Y., USA Stereochemical factors in Prof. Dr. A. H. Beckett biological activity Head of School of Pharmacy, Chelsea College 1,455 (1959) of Science and Technology, Chelsea, London, England Industrial research in the quest Dr. B. Berde for new medicines Head of Pharmaceutical Research and 20, 143 (1976) Development, Sandoz Ltd., Basle, Switzerland Newer diuretics Dr. K. H. Beyer, Jr. 2, 9 (1960) Vice-President, Merck Sharp and Dohme Research Laboratoires, West Point, Pennsylvania, USA Dr. J. E. Baer Director of Pharmacological Chemistry, Merck Institute for Therapeutic Research, West Point, Pennsylvania, USA 298 Index Vol. 1-23

Studies on diphteria in Bombay M. Bhaindarkar 19,241 (1975) Y.S. Nimbkar Haffkine Institute, Parel, Bombay 12, India Bitoscanate in children Dr. B. Bhandari with hookworm disease Dr. L. N. Shrimali 19,6(1975) Department of Child Health, R. N. T. Medical College, Udaipur, India Recent studies on genetic Dr. K. Bhaskaran recombination in Vibrio cholerae Central Drug Research Institute, 19,460 (1975) Lucknow, India Interbiotype conversion Dr. P. Bhattacharya of cholera vibrios by Dr. S. Ray action of mutagens WHO International Vibrio Reference Centre, 19, 466 (1975) Cholera Research Centre, Calcutta 25, India Experience with bitoscanate in Prof. Dr. F. Biagi hookworm disease and Departamento de Parasitologia, Facultad de trichuriasis in Mexico Medicina, Universidad Nacional Aut6noma 19,23 (1975) de Mexico, Mexico Analysis of symptoms and signs Prof. Dr. F. Biagi related with intestinal Dr. R. L6pez parasi tosis in 5,215 cases Dr. J. Viso 19, 10 (1975) Departamento de Parasitologia, Facultad de Medicina, Universidad Nacional Aut6noma de Mexico, Mexico Untersuchungen zur Biochemie und Dr. M. H. Bickel Pharmakologie der Thymoleptika Privatdozent, Medizinisch-Chemisches 11, 121 (1968) Institut der Universitat Bern, Schweiz The p-adrenergic blocking agents, Dr. J. H. Biel pharmacology, and structure-activity Vice-President, Research and Development, relationships Aldrich Chemical Company Inc., Milwaukee, 10,46 (1966) Wisconsin, USA Dr. B. K. B. Lum Department of Pharmacology, Marquette University School of Medicine, Milwaukee, Wisconsin, USA Prostaglandins Dr. J. S. Bindra and Dr. R. Bindra 17,410 (1973) Medical Research Laboratories, Pfizer Inc., Groton, Connecticut, USA The red blood cell membrane as Prof. Dr. L. Bolis a model for targets of drug action Universita degli Studi di Roma, Istituto di 17,59 (1973) Fisiologia Generale, Roma, Italia Epidemiology and public health. Prof. Dr. D. Botero R. Importance of intestinal nematode School of Medicine, University of Antioquia, infections in Latin America Medellin, Colombia 19, 28 (1975) Index Vol. 1-23 299

Some practical problems of Dr. S. G. Browne the epidemiology ofleprosy Director, Leprosy Study Centre, 57a Wimpole in the indian context Street, London, England 18,25 (1974) Die Ionenaustauscher und ihre Prof. Dr. J. Buchi Anwendung in der Pharmazie und Direktor des Pharmazeutischen Institutes der Medizin ETH, Zurich, Schweiz 1, 11 (1959) Wert und Bewertung der Arzneimittel 10,90 (1966) Cyclopropane compounds of Prof. Dr. A. Burger biological interest Professor Emeritus, University of Virginia, 15,227 (1971) Charlottesville, Virginia, USA The state of medicinal science 20,9(1976) Human and veterinary Dr. R. B. Burrows anthelmintics (1965-1971) Mount Holly, New Jersey, USA 17, 108 (1973) The antibody basis of local Dr. W. Burrows immunity to experimental cholera Dr.J. Kaur infection in the rabbit ileal loop University of Chicago, P.O.B. 455, 19,471 (1975) Cobden, Illinois, USA Les derives organiques du fluor Prof. Dr. N.P. Buu-Hoi d'interet pharmacologique Directeur de Laboratoire it l'Institut de chimie 3,9(1961) des substances naturelles du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France Teaching tropical medicine Prof. Dr. K. M. Cahill 18,35 (1974) Tropical Disease Center, 100 East 77th Street, New York City 10021, N. Y., USA Anabolic steroids Prof. Dr. B. Camerino 2, 71 (1960) Director of the Chemical Research Laboratory of Farmitalia, Milan, Italy Prof. Dr. G. Sala Department of Clinical Chemistry and Medical Pathology, University of Milan, and Director of the Department of Pharmaceutical Therapy, Farmitalia, Milan, Italy Imm unosuppression• Dr. G. W. Camiener agents, procedures, Research Laboratories, The Upjohn speculations and prognosis Company, Kalamazoo, Michigan, USA 16,67 (1972) Dr. W.J. Wechter Research Head, Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, Michigan, USA 300 Index Vol. 1-23

Analgesics and their antagonists: Dr. A. F. Casy recent developments Norfolk and Norwich Hospital and University 22, 149 (1978) of East Anglia, Norwich, Norfolk, England Chemical nature and Prof. Dr. C.l. Cavallito pharmacological actions of Professor, Medicinal Chemistry, School of quaternary ammonium salts Pharmacy, University of North Carolina, 2, 135 (1960) Chapel Hill, North Carolina, USA Dr. A.P. Gray Director of the Chemical Research Section, Neisler Laboratories Inc., Decatur, Illinois, USA Contributions of medicinal Prof. Dr. C.l. Cavallito chemistry to medicine - from 1935 Professor, Medicinal Chemistry, School of 12, 11 (1968) Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA Changing influences on goals Prof. Dr. C.l. Cavallito and incentives in drug research Ayerst Laboratories, Inc., New York, N. Y., and development USA 20, 159 (1976) Uber Vorkommen und Bedeutung Dr. A. Cerletti der Indolstruktur in der Medizin Direktor der medizinisch-biologischen und Biologie Forschungsabteilung der Sandoz AG, Basel, 2, 227 (1960) Schweiz Cholesterol and its relation to Prof. Dr. K. K. Chen atherosclerosis Department of Pharmacology, University 1, 127 (1959) School of Medicine, Indianapolis, Indiana, USA Dr. Tsung-Min Lin Senior Pharmacologist, Division of Pharmacologic Research, Lilly Research Laboratories, Indianapolis, Indiana, USA Effect of hookworm disease on Prof. Dr. H. K. Chuttani the structure and Prof. Dr. R. C. Misra function of small bowel· Maulana Azad Medical College 19, 44 (1975) & Associated Irwin and G. B. Pant Hospitals, New Delhi, India The psychotomimetic agents Dr. S. Cohen 15,68 (1971) Director, Division of Narcotic Addiction and Drug Abuse, National Institute of Mental Health, Chevy Chase, Maryland, USA Implementation of disease Prof. Dr. M. l. Colbourne control in Asia and Africa Department of Preventive & Social Medicine, 18,43 (1974) University of Hong Kong, Sassoon Road, Hong Kong Index Vol. 1-23 301

Structure-activity relationships Prof. Dr. J. C. Craig in certain anthelminties Department of Pharmaceutical Chemistry, 3, 75 (1961) University of California, San Francisco, California, USA Dr. M.E. Tate Post Doctoral Fellow, University of New South Wales, Department of Organic Chemistry, Kensington, N.S.W., Australia Contribution of Hafikine to the Dr. B. Cvjetanovic concept and practice of controlled Chief Medical Officer, Bacterial Diseases, field trials of vaccines Division of Communicable Diseases, WHO, 19,481 (1975) Geneva, Switzerland Antifungal agents Prof. Dr. P.F. D'Arcy 22,93 (1978) Dr. E.M. Scott Department of Pharmacy, The Queen's University of Belfast, Northern Ireland Some neuropathologic and Prof. Dr. D.K. Dastur cellular aspects of leprosy Dr. Y. Ramamohan 18,53 (1974) Dr. A. S. Dabholkar Neuropathology Unit, Grant Medical College and J.J. Group of Hospitals, Bombay 8, India Autonomic dysfunction as a Prof. Dr. F.D. Dastur problem in the treatment of Dr. G.J. Bhat tetanus Dr. K.G. Nair 19,245 (1975) Department of Medicine, Seth G. S. Medical College and K.E.M. Hospital, Bombay 12, India Studies on V. parahaemolyticus Dr. B.C. Deb infection in Calcutta as compared Senior Research Officer, Cholera Research to cholera infection Centre, Calcutta, India 19,490 (1975) Biochemical effects of drugs acting Dr. L. Decsi on the central nervous system Specialist in Clinical Chemistry, University 8,53 (1965) Medical School, Pees, Drug research - whence and Dr. R.G. Denkewalter whither Vice-President for Exploratory Research, 10, II (1966) Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. M. Tishler President, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA 302 Index Vol. 1-23

Hypolipidemic agents Dr. G. De Stevens 13,217 (1969) Vice-President and Director of Research, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. W.L. Bencze Research Department, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. R. Hess CIBA Limited, Basle, Switzerland The interface between drug research, Dr. G. De Stevens marketing, management, and social, Executive Vice President & Director of political and regulatory forces Research, Pharmaceuticals Division, CIBA• 20, 181 (1976) GEIGY Corporation, Summit, New Jersey, USA Antihypertensive Agents Dr. G. De Stevens 20, 197 (1976) Dr. M. Wilhelm Pharmaceuticals Division, CIBA-GEIGY Corporation, Summit, New Jersey, USA Transport and accumulation in Dr. W. Dorst biological cell systems interacting Dr. A. F. Bottse with drugs Department of Pharmacology, Vrije 20,261 (1976) Universiteit, Amsterdam, The Netherlands Dr. G.M. Willems Biomedical Centre, Medical Faculty, Maastricht, The Netherlands Immunization of a village, Prof. Dr. N.S. Deodhar a new approach to herd Head of Department of Preventive and Social immunity Medicine, B.J. Medical College, Poona, India 19,252 (1975)

Surgical amoebiasis Dr. A. E. deSa 18,77(1974) Bombay Hospital, Bombay, India Epidemiology of pertussis Dr. J.A. D'Sa 19, 257 (1975) Glaxo Laboratories (India) Limited, Worli, Bombay 25, India Profiles of tuberculosis in rural Prof. Dr. M. D. Deshmukh areas of Maharashtra Honorary Director 18,91 (1974) Dr. K.G. Kulkarni Deputy Director Dr. S. S. Virdi Senior Research Officer Dr. B.B. Yodh Memorial Tuberculosis Reference Laboratory and Research Centre, Bombay, India Aminonuc1eosid-nephrose Dr. U. C. Dubach 7,341 (1964) Privatdozent, Oberarzt an der Medizinischen UniversitiHs-Poliklinik Basel, Schweiz Index Vol. 1-23 303

1m pact of researches in India Dr. N.K. Dutta on the control and treatment Director, Vaccine Institute, of cholera Baroda, India 19, 503 (1975) Laboratory methods in the Dr. D. Duwel screening of anthelmintics Helminthology Department, 19,48 (1975) Farbwerke Hoechst AG, Frankfurt/Main 80, Federal Republic of Germany Progress in immunization Prof. Dr. G. Edsall 19,274 (1975) Department of Microbiology, London School of Hygiene and Tropical Medicine, London W.C.I, England Host factors in the response Prof. Dr. G. Edsall to immunization Department of Microbiology, 19,263 (1975) London School of Hygiene and Tropical Medicine, London, W.C.I, England M.A. Belsey World Health Organization, Geneva, Switzerland D.R. LeBlanc Tulane University School of Public Health and Tropical Medicine, New Orleans, La., USA L. Levine State Laboratory Institute, Boston, Mass., USA Drug-macromolecular interactions: Dr. S. Ehrenpreis implications for pharmacological Associate Professor and Head Department of activity Pharmacology, New York Medical College, 14, 59 (1970) Fifth Avenue at 106th Street, New York, N.Y. 10029, USA Betrachtungen zur Entwicklung von Prof. Dr. G. Ehrhart Heilmitteln Farbwerke Hoechst AG, 10,33 (1966) Frankfurt a.M.-Hochst, BR Deutschland Progress in malaria chemotherapy. Dr. E.F. Elslager Part 1. Repository antimalarial Section Director, Chemistry Department, drugs 13, 170 (1969) Parke, Davis & Company, Ann Arbor, New perspectives on the Michigan, USA chemotherapy of malaria, filariasis and leprosy 18,99 (1974) Recent research in the field of Prof. Dr. V. Erspamer 5-hydroxytryptamine and related Institute of Pharmacology, University of indolealkylamines Parma, Parma, Italy 3,151 (1961) 304 Index Vol. 1-23

Bacteriology at the periphery of Dr. A. L. Furniss the cholera pandemic Public Health Laboratory, Maidstone, 19,513 (1975) England Iron and diphtheria toxin Dr. S. V. Gadre production Dr. S.S. Rao 19,283 (1975) Hafikine Institute, Bombay 12, India Effect of drugs on cholera toxin Dr. B. B. Gaitonde induced fluid in adult rabbit Dr. P. H. Marker ileal loop Dr.N.R.Rao 19,519 (1975) Haffkine Institute, Bombay 12, India Drug action and assay Prof. Dr. E. R. Garrett by microbial kinetics Graduate Research Professor 15,519 (1971) The J. Hillis Miller Health Center, College of Pharmacy, University of Florida, Gainesville, The pharmacokinetic bases Florida, USA of biological response quantification in toxicology, pharmacology and pharmacodynamics 21, 105 (1977) The chemotherapy of Prof. Dr. L.P. Garrod enterobacterial infections Department of Bacteriology, Royal 12,370 (1968) Postgraduate Medical School, Hammersmith Hospital, London, England Metabolism of drugs and other Dr. J.R. Gillette foreign compounds by enzymatic Head, Section on Enzymes Drug Interaction, mechanisms Laboratory of Chemical Pharmacology, 6, 11 (1963) National Heart Institute, Bethesda 14, Maryland, USA The art and science of Dr. A. J. Gordon contemporary drug development Associate Director, Department of Scientific 16, 194 (1972) Affairs, Pfizer Pharmaceuticals, 235 East 42nd Street, New York, USA Dr. S. G. Gilgore President, Pfizer Pharmaceuticals, 235 East 42nd Street, New York, USA Basic mechanisms of drug action Prof. Dr. D.R.H. Gourley 7, 11 (1964) Department of Pharmacology, Isolation and characterization Eastern Virginia Medical School, of membrane drug receptors Norfolk, Virginia, USA 20, 323 (1976) Zusammenhange zwischen Dr. H. Grasshof Konstitution und Wirksamkeit bei Forschungschemiker in Firma M. Woelm, Lokalanasthetica 4,353 (1962) Eschwege, Deutschland Index Vol. 1-23 305

Das Placeboproblem Prof. Dr. H. Haas 1,279 (1959) Leiter der Pharmakologischen Abteilung Knoll AG, Ludwigshafen, und Dozent an der Universitat Heidelberg Dr. H. Fink und Dr. G. Hartefelder Forschungslaboratorien der Knoll AG, Ludwigshafen, Deutschland Clinical field trial of bitoscanate Dr. T. Harinasuta in Necator americanus infection, Dr. D. Bunnag South Thailand Faculty of Tropical Medicine, 19, 64 (1975) Mahidol University, Bangkok, Thailand Pharmacological control of Prof. Dr. M.J.K. Harper reproduction in women The University of Texas, Health 12,47 (1968) Science Center at San Antonio, Contraception - retrospect San Antonio, Texas, USA and prospect 21,293 (1977) Drug latentiation Prof. Dr. N.J. Harper 4,221 (1962) Head of the Department of Pharmacy, University of Aston, Birmingham 4, England Chemotherapy of filariasis Dr. F. Hawking 9, 191 (1966) Clinical Research Centre, Watford Road, Filariasis in India Harrow, Middlesex, England 18, 173 (1974) Recent studies in the field of Dr. R. V. Heinzelman indole compounds Section Head, Organic Chemistry, The 6, 75 (1963) Upjohn Company, Kalamazoo, Michigan, USA Dr. J. Szmuszkovicz Research Chemist, The Upjohn Company, Kalamazoo, Michigan, USA Neuere Entwicklungen auf dem Dr. H. Herbst Gebiete therapeutisch verwendbarer Forschungschemiker in den Farbwerken organischer Schwefelverbindungen Hoechst, Frankfurt a.M., Deutschland 4, 9 (1962) The management of acute Dr. N. Hirschhorn diarrhea in children: Consultant Physician and Staff Associate, an overview Management Sciences for Health, 19, 527 (1975) One Broadway, Cambridge, Mass., USA The tetracyclines Dr. J.J. Hlavka and Dr. J.H. Booth 17, 2lO (1973) Lederle Laboratories, Pearl River, N.Y., USA Relationship of induced antibody Dr. R. B. Hornick titres to resistance to Dr. R. A. Cash experimental human infection Dr. J. P. Libonati 19, 542 (1975) The University of Maryland School of Medicine, Division of Infectious Diseases, Baltimore, Maryland, USA 306 Index Vol. 1-23

Recent applications of mass Mag. Sc. Chem. G. Horvath spectrometry in pharmaceutical Research Chemist, Research Institute for research 18, 399 (1974) Pharmaceutical Chemistry, Budapest, Hungary The pharmacology of homologous Dr. H.R. Ing series Reader in Chemical Pharmacology, Oxford 7,305 (1964) University, and Head of the Chemical Unit of the University Department of Pharmacology, Oxford, England Progress in the experimental Dr. P.J. Islip chemotherapy of helminth infections. The Wellcome Research Laboratories, Part 1. Trematode and cestode Beckenham, Kent, England diseases 17,241 (1973)

Pharmacology of the brain: Prof. Dr. I. Izquierdo the hippocampus, learning Dr. A.G. Nasello and seizures Departamento de Farmacologia, Facultad de 16,211 (1972) Ciencias Quimicas, Upiversidad N acional de C6rdoba, Estafeta 32, C6rdoba, Argentina Cholinergic mechanism - Prof. Dr. J.A. Izquierdo monoamines relation in certain brain Department of Experimental Pharmacology, structures Facultad de Farmacia y Bioquimica, Buenos 16, 334 (1972) Aires, Argentina The development of antifertility Prof. Dr. H. Jackson substances Head of Department of Experimental 7, 133 (1964) Chemotherapy, Christie Hospital and Holt Radium Institute, Paterson Laboratories, Manchester 20, England Agents acting on central Dr. P. C. Jain dopamine receptors Dr. N. Kumar 21,409 (1977) Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India Recent advances in the treatment Dr. P.A.J. Janssen of parasitic infections in man Director, Janssen Pharmaceutica, 18, 191 (1974) Research Laboratories, Beerse, Belgium The levamisole story 20, 347 (1976) A comparative study of bitos can ate, Dr. S. Johnson bephenium hydroxynaphthoate and Department of Medicine III, Christian tetrachlorethylene in hookworm Medical College Hospital, Vellore, infection Tamilnadu, India 19, 70 (1975) Index Vol. 1-23 307

Tetanus in Punjab with particular Prof. Dr. S. S. Jolly reference to the role of muscle Dr. J. Singh relaxants in its management Dr. S. M. Singh 19,288 (1975) Department of Medicine, Medical College, Patiala, India Virulence-enhancing effect of Dr. I. J06 ferric ammonium citrate on Institute for Serobacteriological Production Vibrio cholerae and Research 'HUMAN', WHO International 19,546 (1975) Reference Centre for Bacterial Vaccines, Budapest, Hungary Toxoplasmosis Prof. Dr. B. H. Kean 18,205 (1974) The New York Hospital- Cornell Medical Center, 525 East 68th Street, New York, N.Y., USA Tabellarische Zusammenstellung Dr. R. Kleine uber die Substruktur der Proteine Physiologisch-Chemisches Institut der Martin• 16,364 (1972) Luther-Universitiit, 402 Halle (Saale), DDR Experimental evaluation of anti• Dr. F. Kradolfer tuberculous compounds, with Head of Infectious Diseases Research, special reference to the effect of Biological Research Laboratories, combined treatment Pharmaceutical Division, Ciba-Geigy Ltd., 18,211 (1974) Basle, Switzerland The oxidative metabolism of drugs Dr. F. Kratz and other foreign compounds Medizinische Kliniken und Polikliniken, 17,488 (1973) Justus-Liebig-Universitiit, Giessen, BR Deutschland Die Amidinstruktur in der Prof. Dr. A. Kreutzberger Arzneistofforschung Wissenschaftlicher Abteilungsvorsteher am 11, 356 (1968) Institut fUr pharmazeutische Chemie der Westfalischen Wilhelms-Universitiit Munster, Miinster (Westfalen), Deutschland Present data on the pathogenesis Prof. Dr. G. N. Kryzhanovsky of tetanus Institute of General Pathology and 19,301 (1975) Pathological Physiology, AMS USSR, Tetanus: general and Moscow, USSR pathophysiological aspects; achievements, failures, perspectives of elaboration of the problem 19,314 (1975) Lipophilicity and drug activity Dr. H. Kubinyi 23, 97 (1979) Chemical Research and Development of BASF Pharma Division, Knoll AG, Ludwigshafen/Rhein, Federal Republic of Germany 308 Index Vol. 1-23

Klinisch-pharmakologische Kriterien Prof. Dr. H.P. Kuemmerle in der Bewertung eines neuen Miinchen/Eppstein, BR Deutschland Antibiotikums. Grundlagen und methodische Gesichtspunkte 22,327 (1978) Uber neue Arzneimittel1, 531 (1959), Dr. W. Kunz 2,251 (1960),3,369 (1961), Forschungschemiker in Firma Dr. Schwarz 6,347 (1963), 10, 360 (1966) GmbH, Monheim (Rheinland), Deutschland Die Anwendung von Psychopharmaka Dr. F. Labhardt in der psychosomatischen Medizin Privatdozent, stellvertretender Direktor der 10,530 (1966) psychiatrischen Universitatsklinik, Basel, Schweiz Therapeutic measurement Prof. Dr. D.R. Laurence in tetanus Department of Pharmacology, University 19,323 (1975) College, London, and Medical Unit, University College Hospital Medical School, London, England Physico chemical methods in Dr. H.G. Leemann pharmaceutical chemistry, Head of the Analytical Department in the 1. Spectrofiuorometry Pharmaceutical Division of Sandoz Ltd, 6, 151 (1963) Basle, Switzerland Dr. K. Stich Specialist for Questions in Ultraviolet and Fluorescence Spectrophotometry, Analytical Department, Sandoz Ltd., Bas1e, Switzerland Dr. Margrit Thomas Research Chemist in the Analytical Department Research Laboratory, Sandoz Ltd., Basle, Switzerland Biochemical acyl hydroxylations Dr. W. Lenk 16,229 (1972) Pharmakologisches Institut der Universitat Miinchen, Nussbaumstrasse 26, Miinchen, Deutschalnd Cholinesterase restoring Prof. Dr. G. Leonardi therapy in tetanus Department of Medicine, St. Thomas 19, 329 (1975) Hospital, Portogruaro, Venice, Italy Dr. K.G. Nair Prof. Dr. F.D. Dastur Department of Medicine, Seth G. S. Medical College and K. E. M. Hospital, Bombay 12, India Interactions between androgenic• Dr. O. Linet anabolic steroids and glucocorticoids Sinai Hospital of Detroit, Department of 14, 139 (1970) Medicine, 6767 West Outer Drive, Detroit, Michigan 48235 Index Vol. 1-23 309

Reactivity of bentonite Dr. R. C. Mahajan flocculation, indirect Dr. N. L. Chitkara haem agglutination and casoni Division of Parasitology, Department of tests in hydatid disease Microbiology, Postgraduate Institute of 19, 75 (1975) Medical Education and Research, Chandigarh, India Epidemiology of diphtheria Dr. L.G. Marquis 19,336 (1975) Glaxo Laboratories (India) Limited, Worli, Bombay 25, India Biological activity of the Dr. M. Martin-Smith terpenoids and their derivatives Reader in Pharmaceutical Chemistry, 6,279 (1963) University of Strathclyde, Department of Pharmaceutical Chemistry, Glasgow, C. 1, Scotland Dr. T. Khatoon Lecturer in Chemistry at the Eden Girls College, Dacca, East Pakistan Biological activity of the Dr. M. Martin-Smith terpenoids and their Reader in Pharmaceutical Chemistry, derivatives - recent advances University of Strathclyde, Glasgow, C. 1, 13, 11 (1969) Scotland Dr. W. E. Sneader Lecturer in Pharmaceutical Chemistry, University of Strathclyde, Glasgow, C. 1, Scotland An tih ypertensive agents 1962-1968 Prof. Dr. A. Marxer 13, 101 (1969) Dr. O. Schier Fundamental structures in Chemical Research Department, drug research - Part I Pharmaceuticals Division, Ciba-Geigy Ltd., 20, 385 (1976) Basle, Switzerland Fundamental structures in drug research - Part II 22,27 (1978) Relationships between the chemical Prof. Dr. M. D. Mashkovsky structure and pharmacological All-Union Chemical Pharmaceutical Research activity in a series of synthetic Institute, Moscow, USSR quinuclidine derivatives Dr. L.N. Yakhontov 13,293 (1969) All-Union Chemical Pharmaceutical Research Institute, Moscow, USSR On the understanding of drug Dr. J. W. McFarland potency 15, 123 (1971) Pfizer Medical Research Laboratories, The chemotherapy of intestinal Groton, Connecticut, USA nematodes 16, 157 (1972) 310 Index Vol. 1-23

Zur Beeinfiussung der Strahlen• Dr. H.-J. Melching empfindlichkeit von Saugetieren Privatdozent, Oberassistent am durch chemische Substanzen Radiologischen Institut der Universitat 9, 11 (1966) Freiburg i.Br., Freiburg i.Br., Deutschland Dr. C. Streffer Wissenschaftlicher Mitarbeiter am Radiologischen Institut der Universitat Freiburg i.Br., Freiburg i.Br., Deutschland Analgesian and addiction Dr. L. B. Mellett 5, 155 (1963) Assistant Professor of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA Prof. Dr. L.A. Woods Department of Pharmacology, College of Medicine, State University ofIowa, Iowa City, USA Comparative drug metabolism Dr. L. B. Mellett 13, 136 (1969) Head, Pharmacology & Toxicology, Kettering-Meyer Laboratories, Southern Research Institute, Birmingham, Alabama, USA Pathogenesis of amebic disease Prof. Dr. M.J. Miller 18,225 (1974) Tulane University, Protozoan and helminth parasites - Department of Tropical Medicine, New a review of current treatment Orleans, Louisiana, USA 20,433 (1976) Synopsis der Rheumatherapie Dr. W. Moll 12, 165 (1968) Spezialarzt FMH Innere Medizin - Rheumatologie, Basel, Schweiz On the chemotherapy of cancer Dr. J.A. Montgomery 8, 431 (1965) Kettering-Meyer Laboratory, The relationship of the metabolism Southern Research Institute, Birmingham, of anticancer agents to their activity Alabama, USA 17,320 (1973) The current status of cancer chemotherapy 20,465 (1976) Der Einfiuss der Formgebung auf Prof. Dr. K. Miinzel die Wirkung eines Arzneimittels Leiter der galenischen Forschungsabteilung 10,204 (1966) der F. Hoffmann-La Roche & Co. AG, Basel, Galenische Formgebung und Schweiz Arzneimittelwirkung. Neue Erkenntnisse und Feststellungen 14, 269 (1970) Index Vol. 1-23 311

A field trial with Dr. G.S. Mutalik bitoscanate in India Dr. R.B. Gulati 19,81 (1975) Dr. A. K. Iqbal Department of Medicine, B.J. Medical College and Sassoon General Hospital, Poona, India Comparative study of bitoscanate, Dr. G.S. Mutalik bephenium hydroxynaphthoate Dr. R.B. Gulati and tetrachlorethylene Department of Medicine, in hookworm disease B.J. Medical College and 19, 86 (1975) Sassoon General Hospital, Poona, India Ganglienblocker Dr.K.Nador 2, 297 (1960) o. Professor und Institutsdirektor, Chemisches Institut der Tierarztlichen Universitat, Budapest, Ungam Recent advances in cholera Prof. Dr. D.R. Nalin pathophysiology and Johns Hopkins School of Medicine and therapeutics School of Public Health. Guest Scientist, 19,563 (1975) Cholera Research Hospital, Dacca, Bangladesh Preparing the ground for research: Dr. A.N.D. Nanavati importance of data Assistant Director and Head, Department of 18, 239 (1974) Virology, Hatlkine Institute, Bombay, India Antibody response to two Y. S. Nimbkar cholera vaccines in volunteers R. S. Karbhari 19, 554 (1975) S. Cherian N. G. Chanderkar R. P. Bhamaria P.S. Ranadive Dr. B. B. Gaitonde Haffkine Institute, Parel, Bombay 12, India Die Chemotherapie Prof. Dr. H.-A. Oelkers der Wurmkrankheiten Leiter der pharmakologischen und I, 159 (1959) parasitologischen Abteilung der Firma C.F. Asche & Co., Hamburg-Altona, Deutschland Drug research and Prof. Dr. I. Oswald human sleep University Department of Psychiatry, 22,355 (1978) Royal Edinburgh Hospital, Edinburgh, Scotland An extensive community Dr. S.C. Pal outbreak of acute diarrhoeal Dr. C. Koteswar Rao diseases in children Cholera Research Centre, 19, 570 (1975) Calcutta, India 312 Index Vol. 1-23

3,4-Dihydroxyphenylalanine and Dr. A. R. Patel related compounds Post-Doctoral Research Assistant. 9, 223 (1966) Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA Prof. Dr. A. Burger Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA Mescaline and related compounds Dr. A. R. Patel 11, 11 (1968) Post-Doctoral Research Assistant, Department of Chemistry, University of Virginia, Charlottesville, Virginia, USA Experience with bitoscanate Dr. A. H. Patricia in adults Dr. U. Prabakar Rao 19,90 (1975) Dr. R. Subramaniam Dr. N. Madanagopalan Madras Medical College, Madras, India Monoaminoxydase-Hemmer Prof. Dr. A. Pletscher 2,417 (1960) Direktor der medizinischen Forschungsabteilung F. Hoffmann-La Roche & Co. AG, Basel, und Professor fUr Innere Medizin an der Universitat Basel Dr. K.F. Gey Medizinische Forschungsabteilung F. Hoffmann-La Roche & Co. AG, Basel Schweiz Dr. P. Zeller Chefchemiker in Firma F. Hoffmann-La Roche & Co. AG, Basel, Schweiz What makes a good Dr. N.W. Preston pertussis vaccine? Department of Bacteriology and Virology, 19,341 (1975) University of Manchester, Manchester, Vaccine composition in England relation to antigenic variation of the microbe: is pertussis unique? 19, 347 (1975) Some unsolved problems with vaccines 23,9(1979) Clinical study of diphtheria, Dr. V.B. Raju pertussis and tetanus Dr. V.R. Parvathi 19, 356 (1975) Institute of Child Health and Hospital for Children, Egmore, Madras 8, India Epidemiology of cholera Dr. K. Rajyalakshmi in Hyderabad Dr. P.V. Ramana Rao 19,578 (1975) Institute of Preventive Medicine, Hyderabad, Andhra Pradesh, India Index Vol. 1-23 313

Problems of malaria eradication Dr. V.N. Rao in India Joint Director of Health Services (Health), 18, 245 (1974) Maharashtra, Bombay, India The photochemistry of drugs and Dr. S. T. Reid related substances Lecturer in Chemical Pharmacology, 11,48 (1968) Experimental Pharmacology Division, Institute of Physiology, The University, Glasgow, W.2, Scotland Orale Antikoagulantien Dr. E. Renk 11,226 (1968) Dr. W.G. Stoll Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel, Schweiz Functional significance of the Prof. Dr. R. Rott various components of the Institut fUr Virologie, Justus-Liebig• influenza virus 18, 253 (1974) UniversitlH, Giessen, Deutschland Role of beta-adrenergic Prof. Dr. G.S. Sainani blocking drug propranolol Head, Upgraded Department of Medicine, in severe tetanus B.J. Medical College and Sassoon General 19,361 (1975) Hospitals, Poona, India Dr. K. L. Jain Prof. Dr. V.R.D. Deshpande Dr. A. B. Balsara Dr. S.A. Iyer Medical College and Hospital, Nagpur, India Studies on Vibrio parahaemolyticus Dr. F. L. Saldanha in Bombay Dr. A. K. Patil 19, 586 (1975) Dr. M. V. Sant Haflkine Institute, Parel, Bombay 12, India Clinical experience with Dr. M.R. Samuel bitoscanate Head of the Department of Clinical 19,96 (1975) Development, Medical Division, Hoechst Pharmaceuticals Limited, Bombay, India Tetanus: Situational clinical Dr. R.K.M. Sanders trials and therapeutics Dr. M. L. Peacock 19,367 (1975) Dr. B. Martyn Dr. B. D. Shende The Duncan Hospital, Raxaul, Bihar, India Epidemiological studies on Dr. M. V. Sant cholera in non-endemic regions W.N. Gatlewar with special reference to the S. K. Bhindey problem of carrier state during Haflkine Institute, Parel, Bombay 12, India epidemic and non-epidemic period 19, 594 (1975) 314 Index Vol. 1-23

Epidemiological and biochemical Dr. M. V. Sant, W.N. Gatlewar and studies in filariasis in four T.U.K. Menon villages near Bombay Department of Zoonosis and of Research 18,269 (1974) Divison of Microbiology, Hafikine Institute, Bombay, India Hookworm anaemia and Prof. Dr. A. K. Saraya intestinal malabsorption Prof. Dr. B.N. Tandon associated with hookworm Department of Pathology and Department of infestation Gastroenterology, All India Institute of 19, 108 (1975) Medical Sciences, New Delhi, India The effects of structural alteration Dr. L. H. Sarett on the anti-inflammatory Director of Synthetic Organic Chemistry, properties of hydrocortisone Merck Sharp & Dohme Research 5,11 (1963) Laboratories, Rahway, New Jersey, USA Dr. A. A. Patchett Director of the Department of Synthetic Organic Chemistry, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. S. Steelman Director of Endocrinology, Merck Institute for Therapeutic Research, Rahway, New Jersey, USA The impact of natural product Dr. L. H. Sarett research on drug discovery Senior Vice-President for Science and 23,51 (1979) Technology, Merck & Co., Inc., Rahway New Jersey, USA Anti-filariasis campaign: its Prof. Dr. M. Sasa history and future prospects Professor of Parasitology, Director of the 18,259 (1974) Institute of Medical Science, University of Tokyo, Tokyo, Japan Immuno-diagnosis of Prof. Dr. T. Sawada helminthic infections Dr. K. Sato 19, 119 (1975) Dr. K. Takei Department of Parasitology, School of Medicine, Gunma University, Maebashi, Japan Immuno-diagnosis in Prof. Dr. T. Sawada filarial infection Dr. K. Sato 19, 128 (1975) Dr. K. Takei Department of Parasitology, School of Medicine, Gunma University, Maebashi, Japan Dr. M. M. Goil Department of Zoology, Bareilly College, Bareilly (U.P.), India Index Vol. 1-23 315

Quantitative structure• Dr. A.K. Saxena activity relationships Dr. S.Ram 23, 199 (1979) Medicinal Chemistry Division, Central Drug Research Institute, Lucknow, India Phenothiazine und Azaphenothiazine Dr. E. Schenker als Arzneimittel Forschungschemiker in der Sandoz AG, 5,269 (1963) Basel, Schweiz Dr. H. Herbst Forschungstechniker in den Farbwerken Hoechst, Frankfurt a.M., Deutschland Antihypertensive agents Dr. E. Schlittler 4,295 (1962) Director of Research of CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr.J. Druey Director of the Department of Synthetic Drug Research of CIBA Ltd., Basle, Switzerland Dr. A. Marxer Research Chemist of CIBA Ltd., Basle, and Lecturer at the University of Berne, Switzerland Die Anwendung radioaktiver Isotope Prof. Dr. K.E. Schulte in der pharmazeutischen Forschung Direktor des Instituts fUr Pharmazie und 7, 59 (1964) Lebensmittelchemie der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland Dr. Ingeborg Mleinek Leiterin des Isotopen-Laboratoriums, Institut fUr Pharmazie und Lebensmittelchemie der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland Natiirliche und synthetische Acetylen• Prof. Dr. K. E. Schulte Verbindungen als Arzneistoffe Direktor des Instituts fUr pharmazeutische 14,387 (1970) Chemie der Westfalischen Wilhelms• Universitlit Munster, Munster (Westfalen), Deutschland Dr. G. Rucker Dozent fUr pharmazeutische Chemie an der Westfalischen Wilhelms-Universitlit Munster, Munster (Westfalen), Deutschland The structure and biogenesis of Dr. W.A. Sexton certain antibiotics Research Director of the Pharmaceuticals 2,591 (1960) Division of Imperial Chemical Industries Ltd., Wilmslow, Cheshire, England 316 Index Vol. 1-23

Role of periodic deworming of Prof. Dr. P.M. Shah preschool community in national Institute of Child Health nutrition programmes Dr. A. R. Junnarkar 19, 136 (1975) Reader in Preventive and Social Medicine Dr. R. D. Khare Research Assistant, Institute of Child Health, J.J. Group of Govemment Hospitals and Grant Medical College, Bombay, India Ayurvedic medicine - past and Dr. Shiv Sharma present 'Baharestan', Bomanji Petit Road, Cumbalia 15, 11 (1971) Hill, Bombay, India Mechanisms of anthelmintic Prof. Dr. U.K. Sheth action Seth G. S. Medical College and K. E. M. 19, 147 (1975) Hospital, Parel, Bombay 12, India Some often neglected factors in the Dr. C.E.G. Smith control and prevention of Dean, London School of Hygiene and communicable diseases Tropical Medicine, Keppel Street, London, 18,277 (1974) England Tetanus and its prevention Dr. J. W.G. Smith 19,391 (1975) Epidemiological Research Laboratory, Central Public Health Laboratory, London, England Growth of Clostridium telani in vivo Dr. J. W.G. Smith 19, 384 (1975) Epidemiological Research Laboratory, Central Public Health Laboratory, London, England Dr. A.G. Maciver Department of Morbid Anatomy, Faculty of Medicine, Southampton University, Southampton, England The biliary excretion and Dr. R. L. Smith enterohepatic circulation of drugs Senior Lecturer in Biochemistry at St. Mary's and other organic compounds Hospital Medical School (University of 9, 299 (1966) London), Paddington, London, W.2, England On the relation between chemical Prof. Dr. J. R. Smythies structure and function in certain Department of Psychiatry, tumor promoters and anti-tumor University of Alabama in Birmingham agents Medical Center, Birmingham, Alabama, USA 23,63 (1979) Gram-negative bacterial Dr. E. S. Snell endotoxin and the pathogenesis Glaxo Laboratories Limited, of fever Greenford, Middlesex, England 19,402 (1975) Index Vol. 1-23 317

Strukturelle Betrachtungen der Dr. K. Stach Psychopharmaka: Versuch einer Stellvertretender Leiter der Chemischen Korrelation von chemischer Forschung der C. F. Boehringer & Sohne Konstitution und klinischer Wirkung GmbH, Mannheim-Waldhof, Deutschland 9, 129 (1966) Dr. W. Poldinger Oberarzt flir klinische Psychopharmakologie an der Psychiatrischen Universitatsklinik Basel, Basel, Schweiz Chemotherapy of intestinal Dr. O.D. Standen helminthiasis The Wellcome Research Laboratories, 19, 158 (1975) Beckenham, Kent, England The leishmaniases Dr. E. A. Steck 18,289 (1974) Department of the Army, Walter Reed Army Institute of Research, Division of Medicinal Chemistry, Washington, D.C., USA The benzodiazepine story Dr. L. H. Sternbach 22,229 (1978) Research Department, Hoffmann-La Roche Inc., Nutley, New Jersey, USA Progress in sulfonamide research Dr. Th. Struller 12, 389 (1968) Research Department, Problems of medical practice and F. Hoffmann-La Roche & Co. Ltd., of medical-pharmaceutical research Basle, Switzerland 20,491 (1976) Antiviral agents Dr. D.L. Swallow 22, 267 (1978) Pharmaceuticals Division, Imperial Chemical Industries Limited, Alderley Park, Macclesfield, Cheshire, England Antiarrhythmic compounds Prof. Dr. L. Szekeres 12,292 (1968) Head of the Department of Pharmacology, School of Medicine, University ofSzeged, Szeged, Hungary Dr. J. G. Papp Senior Lecturer, University Department of Pharmacology, Oxford, England Practically applicable results Prof. Dr. M. Tausk of twenty years of research State University of Utrecht, Faculty of in endocrinology Medicine, Utrecht, Netherlands 12, 137 (1968) Age profile of diphtheria Prof. Dr. N.S. Tibrewala in Bombay Dr. R. D. Potdar 19,412 (1975) Dr. S. B. Talathi Dr. M.A. Ramnathkar Dr. A.D. Katdare Topiwala National Medical College, BYL Nair Hospital and Kasturba Hospital for Infectious Diseases, Bombay 11, India 318 Index Vol. 1-23

Antibakterielle Chemotherapie der Dr. F. Trende1enburg Tuberku10se Leitender Arzt der Robert-Koch-Abtei1ung 7, 193 (1964) der Medizinischen Universitiitskliniken, Homburg, Saar, Deutschland Diphtheria Prof. Dr. P.M. Udani 19,423 (1975) Dr. M. M. Kumbhat Dr. U.S. Bhat Dr. M.S. Nadkarni Dr. S.K. Bhave Dr. S.G. Ezuthachan Dr. B. Kamath The Institute of Child Health, 1.1. Group of Hospita1s~ and Grant Medical College, Bombay 8, India Bio10gische Oxydation und Reduktion Prof. Dr. H. Ueh1eke am Stickstoff aromatischer Amino• Pharmakologisches Institut der Universitiit und Nitroderivate und ihre Fo1gen Tiibingen, 74 Tiibingen, Deutschland fUr den Organismus 8, 195 (1965) Stoffwechse1 von Arzneimitteln a1s Ursache von Wirkungen, Nebenwir• kungen und Toxizitiit 15,147 (1971) Mode of death in tetanus Prof. Dr. H. Vaishnava 19,439 (1975) Dr. C. Bhawal Dr. Y.P. Munjal Department of Medicine, Mau1ana Azad Medical College and Associated Irwin and G.B. Pant Hospitals, New Delhi, India Comparative evaluation of Prof. Dr. B.l. Vakil amoebicidal drugs Dr. N.l. Dalal 18, 353 (1974) Department of Gastroenterology, Grant Comparative efficacy of Medical College and 1.1. Group of newer anthelmintics Hospitals, Bombay, India 19, 166 (1975) Cephalic tetanus Prof. Dr. B.l. Vakil 19,443 (1975) Prof. Dr. B. S. Singhal Dr. S. S. Pandya Dr. P.F. Irani 1.1. Group of Hospitals and Grant Medical College, Bombay, India Methods of monitoring adverse Prof. Dr. 1. Venulet reactions to drugs Division of Clinical Pharmacology, 21,231 (1977) Department of Medicine, Hopital Cantonal Aspects of social pharmacology and University of Geneva, Geneva, 22, 9 (1978) Switzerland. Formerly: Senior Project Officer, WHO Research Centre for International Monitoring of Adverse Reactions to Drugs, Geneva, Switzerland Index Vol. 1-23 319

The current status of cholera Dr. W.F. Verwey toxoid research in the United Dr. J. C. Guckian States Dr. J. Craig 19,602 (1975) Dr. N. Pierce Dr. J. Peterson Dr. H. Williams, Jr. The University of Texas Medical Branch, Galveston, State University of New York Medical Center (Downstate), and Johns Hopkins University School of Medicine, USA Cell-kinetic and pharmacokinetic Prof. Dr. M. von Ardenne aspects in the use and further Forschungsinstitut Manfred von Ardenne, development of cancerostatic drugs Dresden, GDR 20,521 (1976) The problem of diphteria Prof. Dr. M.M. Wagle as seen in Bombay Dr. R. R. Sanzgiri 19,452 (1975) Dr. Y.K. Amdekar Institute of Child Health, J.J. Group of Hospitals and Grant Medical College, Bombay 8, India

Cell-wall antigens of V. cholerae Dr. Y. Watanabe and their implication in cholera Dr. R. Ganguly immunity Bacterial Diseases, Division of Communicable 19,612 (1975) Diseases, World Health Organization, Geneva 27, Switzerland Where is immunology taking us? Dr. W.J. Wechter 20,573 (1976) Dr. Barbara E. Loughman Hypersensitivity Diseases Research, The Upjohn Company, Kalamazoo, Michigan, USA A pharmacological approach to Dr. G.B. West allergy Reader in the School of Phannacy, 3,409 (1961) Department of Pharmacology, University of London, London, England A new approach to the medical Dr. G.B. West interpretation of shock Scientific Secretary, The British Industrial 14, 196 (1970) Biological Research Association, Woodmansteme Road, Carshalton, Surrey, England Dr. M. S. Starr Department of Pharmacology, St. Mary's Hospital Medical School, University of London, London, England Adverse reactions of sugar polymers Dr. G.B. West in animals and man Department of Paramedical Sciences, North• 23, 27 (1979) East London Polytechnic, London, England 320 Index Vol. 1-23

Some biochemical and Dr. M. W. Whitehouse pharmacological properties of anti• Lecturer in Biochemistry at the University of inflammatory drugs Oxford, Oxford, England 8,321 (1965) Wirksamkeit und Nebenwirkungen Dr. K. Wiesner von Metronidazol in der Therapie Tierarzt, wissenschaftlicher Mitarbeiter der der Trichomonasis Pharmawissenschaftlichen Literaturabteilung, 9,361 (1966) Farbenfabriken Bayer AG, Leverkusen, Deutschland Dr. H. Fink Leiter der Pharmawissenschaftlichen Literaturabteilung, Farbenfabriken Bayer AG, Leverkusen, Deutschland Nonsteroid antiinflammatory Dr. C.A. Winter agents Senior Investigator Pharmacology, Merck 10, 139 (1966) Institute for Therapeutic Research, West Point, Pennsylvania, USA Basic research in the Dr. O. Wintersteiner US pharmaceutical industry The Squibb Institute for Medical Research, 15,204 (1971) New Brunswick, New Jersey, USA The chemotherapy of amoebiasis Dr. G. Woolfe 8, 11 (1965) Head of the Chemotherapy Group of the Research Department at Boots Pure Drug Company Ltd., Nottingham, England Antimetabolites and their revolution Dr. D. W. Woolley in pharmacology The Rockefeller Institute, New York, USA 2,613 (1960) Krebswirksame Antibiotika aus Dr. Kh. Zepf Actinom yceten Forschungschemiker im biochemischen und 3,451 (1961) mikrobiologischen Laboratorium der Farbwerke Hoechst, Frankfurt a.M., Deutschland Dr. Christa Zepf Referentin f"Ur das Chemische Zentralblatt, Kelkheim (Taunus), Deutschland Lysostaphin: model for a Dr. W.A. Zygmunt specific enzymatic approach Department of Biochemistry, Mead Johnson to infectious disease Research Center, Evansville, Indiana, USA 16, 309 (1972) Dr. P.A. Tavormina Director of Biochemistry, Mead Johnson Research Center, Evansville, Indiana, USA