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Supplementary material BMJ Open Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily <1946 to September 16, 2019> # Searches Results 1 exp Hypertension/ 247434 2 hypertens*.tw,kf. 420857 3 ((high* or elevat* or greater* or control*) adj4 (blood or systolic or diastolic) adj4 68657 pressure*).tw,kf. 4 1 or 2 or 3 501365 5 Sex Characteristics/ 52287 6 Sex/ 7632 7 Sex ratio/ 9049 8 Sex Factors/ 254781 9 ((sex* or gender* or man or men or male* or woman or women or female*) adj3 336361 (difference* or different or characteristic* or ratio* or factor* or imbalanc* or issue* or specific* or disparit* or dependen* or dimorphism* or gap or gaps or influenc* or discrepan* or distribut* or composition*)).tw,kf. 10 or/5-9 559186 11 4 and 10 24653 12 exp Antihypertensive Agents/ 254343 13 (antihypertensiv* or anti-hypertensiv* or ((anti?hyperten* or anti-hyperten*) adj5 52111 (therap* or treat* or effective*))).tw,kf. 14 Calcium Channel Blockers/ 36287 15 (calcium adj2 (channel* or exogenous*) adj2 (block* or inhibitor* or 20534 antagonist*)).tw,kf. 16 (agatoxin or amlodipine or anipamil or aranidipine or atagabalin or azelnidipine or 86627 azidodiltiazem or azidopamil or azidopine or belfosdil or benidipine or bepridil or brinazarone or calciseptine or caroverine or cilnidipine or clentiazem or clevidipine or columbianadin or conotoxin or cronidipine or darodipine or deacetyl n nordiltiazem or deacetyl n o dinordiltiazem or deacetyl o nordiltiazem or deacetyldiltiazem or dealkylnorverapamil or dealkylverapamil or deutolperisone or devapamil or dexniguldipine or dexverapamil or diclofurime or diltiazem or diperdipine or diproteverine or dopropidil or dotarizine or efonidipine or elgodipine or elnadipine or emopamil or enecadin or eperisone or etripamil or falipamil or fantofarone or fasudil or felodipine or fendiline or flordipine or flosatidil or fluspirilene or fostedil or furnidipine or gabapentin or gallopamil or iganidipine or isoperisone or isradipine or lacidipine or lemildipine or lercanidipine or lifarizine or lomerizine or manidipine or mepamil or mepirodipine or mesudipine or meta nisoldipine or mibefradil or mirogabalin or modipafant or monatepil or n methylbepridil or n nordiltiazem or naltiazem or nexopamil or nicardipine or nifedipine or niguldipine or niludipine or nilvadipine or nimodipine or nisoldipine or nitrendipine or norgallopamil or norverapamil or olradipine or omega agatoxin or omega conotoxin or oxodipine or palonidipine or perhexiline or pimozide or pinokalant or pontuc or pranidipine or Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open pregabalin or riodipine or ronipamil or sagandipine or semotiadil or silperisone or siratiazem or tamolarizine or teludipine or temiverine or terodiline or tolperisone or trelnarizine or verapamil or watanidipine or xestospongin C or zonisamide).nm,tw,kf. 17 Calcium/ 263148 18 limit 17 to yr="1966-1967" 2861 19 Calcium/ai 1873 20 limit 19 to yr="1968-1981" 707 21 Ion Channels/ 34899 22 limit 21 to yr="1979-1981" 1461 23 exp Angiotensin-Converting Enzyme Inhibitors/ 42827 24 (("Angiotensin-Converting Enzyme" or ACE) adj5 (inhibit* or antagoni*)).tw,kf. 37120 25 ("kininase ii" adj2 (antagoni* or inhibit*)).tw,kf,nm. 150 26 (alacepril or altiopril or ancovenin or benazepril or benazeprilat or captopril or 30970 ceranapril or cilazapril or cilazaprilat or deacetylalacepril or delapril or enalapril or enalaprilat or epicaptopril or fasidotril or fasidotrilat or foroxymithine or fosinopril or fosinoprilat or gemopatrilat or idrapril or ilepatril or imidapril or imidaprilat or indolapril or libenzapril or lisinopril or moexipril or moexiprilat or omapatrilat or pentopril or pentoprilat or perindopril or perindoprilat or pivopril or quinapril or quinaprilat or ramipril or ramiprilat or rentiapril or s nitrosocaptopril or sampatrilat or spirapril or spiraprilat or temocapril or temocaprilat or teprotide or trandolapril or trandolaprilat or utibapril or utibaprilat or vasopeptidase inhibitor or zabicipril or zabiciprilat or zofenopril or zofenoprilat).nm,tw,kf. 27 Enzyme Inhibitors/ 129341 28 limit 27 to yr="1975-1987" 1738 29 exp Angiotensin Receptor Antagonists/ 22877 30 (angiotensin adj2 receptor adj2 (blocker* or antagonist*)).tw,kf,nm. 17015 31 (abitesartan or azilsartan or candesartan or elisartan or embusartan or eprosartan or 20235 fimasartan or fonsartan or forasartan or irbesartan or losartan or milfasartan or olmesartan or olodanrigan or pomisartan or pratosartan or ripisartan or saprisartan or sartan derivative or sparsentan or tasosartan or telmisartan or valsartan or zolasartan or irbesarten).nm,tw,kf. 32 Angiotensin II Type 1 Receptor Blockers/ 8428 33 limit 32 to yr="2004-2010" 5146 34 beta-blocker*.tw,kf,nm. 29516 35 (adaprolol or afurolol or alprenolol or alprenolol derivative or befunolol or beta 1 72506 adrenergic receptor blocking agent or beta 2 adrenergic receptor blocking agent or beta 3 adrenergic receptor blocking agent or bfe 55 or bopindolol or bornaprolol or bromoacetylalprenololmenthane or bucindolol or bucumolol or bufetolol or bufuralol or bunitrolol or bunolol or bupranolol or butofilolol or carazolol or carpindolol or carteolol or carvedilol or cloranolol or deacetylmetipranolol or dexpropranolol or diacetolol or dichlorisoprenaline or dihydroalprenolol or dilevalol or diprafenone or Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open ersentilide or exaprolol or falintolol or falintolol oxalate or flestolol or hydroxybenzylpindolol or indenolol or iodopindolol or iprocrolol or isamoltane or isoxaprolol or labetalol or levobunolol or levomoprolol or mepindolol or mercuderamide or metipranolol or moprolol or nadolol or nifenalol or oberadilol or oxprenolol or pafenolol or pamatolol or penbutolol or pindolol* or primidolol or prizidilol or procinolol or pronetalol or propranolol or proxodolol or ridazolol or soquinolol or soquinolol mucate or sotalol or spirendolol or tazolol or tertatolol or tienoxolol or tilisolol or timolol or tolamolol or toliprolol or trasitensin or trepress or tribendilol or viskaldix or xibenolol or zoleprodolol or acebutolol or atenolol or betaxolol or bisoprolol fumarate or carteolol hydrochloride or metoprolol tartrate or metoprolol succinate or penbutolol sulfate or solotol hydrochloride).nm,tw,kf. 36 exp Diuretics/ 78470 37 diuretic*.tw,kf. 38785 38 Furosemide/ 11727 39 (furosemide or frusemide or fursemide or frusemid or fusid or lasix or errolon or 16850 furanthril or furantral).nm,tw,kf. 40 (acetazolamide or alilusem or amisometradine or ammonium acetate or bemitradine 61739 or besulpamide or brocrinat or chlormerodrin or diclofenamide or epinine or ethoxzolamide or fenquizone or ibopamine or indapamide or meralluride or mercaptomerin or mercumatilin or merethoxylline or mersalyl or methazolamide or meticrane or niravoline or osmotic diuretic agent or pamabrom or perhexiline or perhexiline maleate or sitalidone or skf 105494 or theobromine or theophylline or tiamizide or tienilic acid or tienoxolol or traxanox or triniton or tripamide or viskaldix or chlorthalidone or chlorothiazide or hydrochlorothiazide or metolazone or amiloride hydrochloride or triamterene or bumetanide or bisoprolol or bendrofluazide).nm,tw,kf. 41 exp Mineralocorticoid Receptor Antagonists/ 9160 42 (antialdosteron* or anti aldosterone* or spironolacton* or eplerenon* or canreno* or 12684 ((aldosterone* or mineralocorticoid*) adj3 antagonist*)).tw,kf,nm. 43 (trilostane or apararenone or canrenoate potassium or canrenoic acid or canrenone 9903 or canrenone derivative or eplerenone or esaxerenone or finerenone or mespirenone or mexrenoate potassium or mexrenoic acid or mexrenone or oxprenoate potassium or spironolactone or spiroxasone).nm,tw,kf. 44 Aldosterone/ 23836 45 limit 44 to yr="1966-1977" 4553 46 alpha?blocker*.tw,kf,nm. 32 47 (doxazosin mesylate or prazosin hydrochloride or terazosin hydrochloride).tw,kf. 208 48 Methyldopa.tw,kf,nm. 4633 49 Central agonist*.tw,kf,nm. 14 50 (alpha methyldopa or clonidine hydrochloride or guanabenz acetate or guanfacine 1228 hydrochloride).tw,kf. 51 (Peripheral adj2 adrenergic adj2 inhibitor*).tw,kf. 1 Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open 52 (guanadrel or guanethidine monosulfate or reserpine).nm,tw,kf. 18266 53 (blood vessel dilator* or vasodilator*).tw,kf,nm. 68457 54 (hydralazine hydrochloride or minoxidil).tw,kf,nm. 2200 55 12 or 13 or 14 or 15 or 16 or 18 or 20 or 22 or 23 or 24 or 25 or 26 or 28 or 29 or 30 567100 or 31 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43 or 45 or 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 56 11 and 55 3304 57 (Animals/ or Models, animal/ or Disease models, animal/) not Humans/ 4582726 58 ((animal or animals or canine* or cat or cats or dog or dogs or feline or hamster* or 2320147 lamb or lambs or mice or monkey or monkeys or mouse or murine or pig or pigs or piglet* or porcine or primate* or rabbit* or rats or rat or rodent* or sheep* or veterinar*) not (human* or patient*)).ti,kf,jw. 59 57 or 58 4970127 60 56 not 59 3117 61 (exp child/ or exp infant/ or adolescent/) not exp adult/ 1820849 62 (newborn* or new-born* or neonat* or neo-nat* or infan* or child* or adolesc* or 1433304 paediatr* or pediatr* or baby* or babies* or toddler* or kid or kids or boy* or girl* or juvenile* or teen* or youth* or pubescen* or preadolesc* or prepubesc* or preteen or tween).ti. 63 (pediatr* or paediatr*).jw. 551915 64 61 or 62 or 63 2368164 65 60 not 62 3045 66 limit 65 to (comment or editorial or letter) 35 67 65 not 66 3010 68 remove duplicates from 67 3006 Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128.
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    USOO6264,917B1 (12) United States Patent (10) Patent No.: US 6,264,917 B1 Klaveness et al. (45) Date of Patent: Jul. 24, 2001 (54) TARGETED ULTRASOUND CONTRAST 5,733,572 3/1998 Unger et al.. AGENTS 5,780,010 7/1998 Lanza et al. 5,846,517 12/1998 Unger .................................. 424/9.52 (75) Inventors: Jo Klaveness; Pál Rongved; Dagfinn 5,849,727 12/1998 Porter et al. ......................... 514/156 Lovhaug, all of Oslo (NO) 5,910,300 6/1999 Tournier et al. .................... 424/9.34 FOREIGN PATENT DOCUMENTS (73) Assignee: Nycomed Imaging AS, Oslo (NO) 2 145 SOS 4/1994 (CA). (*) Notice: Subject to any disclaimer, the term of this 19 626 530 1/1998 (DE). patent is extended or adjusted under 35 O 727 225 8/1996 (EP). U.S.C. 154(b) by 0 days. WO91/15244 10/1991 (WO). WO 93/20802 10/1993 (WO). WO 94/07539 4/1994 (WO). (21) Appl. No.: 08/958,993 WO 94/28873 12/1994 (WO). WO 94/28874 12/1994 (WO). (22) Filed: Oct. 28, 1997 WO95/03356 2/1995 (WO). WO95/03357 2/1995 (WO). Related U.S. Application Data WO95/07072 3/1995 (WO). (60) Provisional application No. 60/049.264, filed on Jun. 7, WO95/15118 6/1995 (WO). 1997, provisional application No. 60/049,265, filed on Jun. WO 96/39149 12/1996 (WO). 7, 1997, and provisional application No. 60/049.268, filed WO 96/40277 12/1996 (WO). on Jun. 7, 1997. WO 96/40285 12/1996 (WO). (30) Foreign Application Priority Data WO 96/41647 12/1996 (WO).
  • Tetrapeptide Renin Inhibitors Having a Novel C-Terminal Amino Acid

    Tetrapeptide Renin Inhibitors Having a Novel C-Terminal Amino Acid

    Europaisches Patentamt 0 312 157 European Patent Office © Publication number: A2 Office europeen des brevets EUROPEAN PATENT APPLICATION A61K 37/64 © Application number:. 8820221 0.6 © int. CI.4: C07K 5/02 , © Date of filing: 05.10.88 §) Priority: 13.10.87 US 107212 © Applicant: MERCK & CO. INC. 126, East Lincoln Avenue P.O. Box 2000 © Date of publication of application: Rahway New Jersey 07065-0900(US) 19.04.89 Bulletin 89/16 © Inventor: Chakravarty, Prasun K. © Designated Contracting States: 16 Churchill Road CH DE FR GB IT LI NL Edison New Jersey 08820(US) Inventor: Greenlee, William J. 115 Herrick Avenue Teaneck New Jersey 07666(US) Inventor: Parsons, William H. 2171 Oliver Street Rahway New Jersey 07065(US) Inventor: Schoen, William 196 White Birch Road Edison New Jersey 08837(US) © Representative: Hesketh, Alan, Dr. European Patent Department Merck & Co., Inc. Teriings Park Eastwick Road Harlow Essex, CM20 2QR(GB) © Tetrapeptide renin inhibitors having a novel c-terminal amino acid. © Tetrapeptide enzyme inhibitors of the formula: A-N A N c JM is CM •10b It II 0 0 < r ^2 CM and analogs thereof which inhibit renin and are useful for treating various forms of renin-associatea hypertension, hyperaldosteronism and congestive heart failure; compositions containing these renin-inhibi- CO tory peptides, optionally with other antihypertensive agents; and methods of treating hypertension, hyperal- dosteronism or congestive heart failure or of establishing renin as a causative factor in these problems Q. employing the novel tetrapeptides.
  • Partial Agreement in the Social and Public Health Field

    Partial Agreement in the Social and Public Health Field

    COUNCIL OF EUROPE COMMITTEE OF MINISTERS (PARTIAL AGREEMENT IN THE SOCIAL AND PUBLIC HEALTH FIELD) RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies, and superseding Resolution AP (82) 2) AND APPENDIX I Alphabetical list of medicines adopted by the Public Health Committee (Partial Agreement) updated to 1 July 1988 APPENDIX II Pharmaco-therapeutic classification of medicines appearing in the alphabetical list in Appendix I updated to 1 July 1988 RESOLUTION AP (88) 2 ON THE CLASSIFICATION OF MEDICINES WHICH ARE OBTAINABLE ONLY ON MEDICAL PRESCRIPTION (superseding Resolution AP (82) 2) (Adopted by the Committee of Ministers on 22 September 1988 at the 419th meeting of the Ministers' Deputies) The Representatives on the Committee of Ministers of Belgium, France, the Federal Republic of Germany, Italy, Luxembourg, the Netherlands and the United Kingdom of Great Britain and Northern Ireland, these states being parties to the Partial Agreement in the social and public health field, and the Representatives of Austria, Denmark, Ireland, Spain and Switzerland, states which have participated in the public health activities carried out within the above-mentioned Partial Agreement since 1 October 1974, 2 April 1968, 23 September 1969, 21 April 1988 and 5 May 1964, respectively, Considering that the aim of the Council of Europe is to achieve greater unity between its members and that this
  • Pharmaceuticals Appendix

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    )&f1y3X PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE )&f1y3X PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 3 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. Product CAS No. Product CAS No. ABAMECTIN 65195-55-3 ADAPALENE 106685-40-9 ABANOQUIL 90402-40-7 ADAPROLOL 101479-70-3 ABECARNIL 111841-85-1 ADEMETIONINE 17176-17-9 ABLUKAST 96566-25-5 ADENOSINE PHOSPHATE 61-19-8 ABUNIDAZOLE 91017-58-2 ADIBENDAN 100510-33-6 ACADESINE 2627-69-2 ADICILLIN 525-94-0 ACAMPROSATE 77337-76-9 ADIMOLOL 78459-19-5 ACAPRAZINE 55485-20-6 ADINAZOLAM 37115-32-5 ACARBOSE 56180-94-0 ADIPHENINE 64-95-9 ACEBROCHOL 514-50-1 ADIPIODONE 606-17-7 ACEBURIC ACID 26976-72-7 ADITEREN 56066-19-4 ACEBUTOLOL 37517-30-9 ADITOPRIME 56066-63-8 ACECAINIDE 32795-44-1 ADOSOPINE 88124-26-9 ACECARBROMAL 77-66-7 ADOZELESIN 110314-48-2 ACECLIDINE 827-61-2 ADRAFINIL 63547-13-7 ACECLOFENAC 89796-99-6 ADRENALONE 99-45-6 ACEDAPSONE 77-46-3 AFALANINE 2901-75-9 ACEDIASULFONE SODIUM 127-60-6 AFLOQUALONE 56287-74-2 ACEDOBEN 556-08-1 AFUROLOL 65776-67-2 ACEFLURANOL 80595-73-9 AGANODINE 86696-87-9 ACEFURTIAMINE 10072-48-7 AKLOMIDE 3011-89-0 ACEFYLLINE CLOFIBROL 70788-27-1