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Supplementary material BMJ Open

Ovid MEDLINE(R) and Epub Ahead of Print, In-Process & Other Non-Indexed Citations and Daily <1946 to September 16, 2019> # Searches Results 1 exp / 247434 2 hypertens*.tw,kf. 420857 3 ((high* or elevat* or greater* or control*) adj4 (blood or systolic or diastolic) adj4 68657 pressure*).tw,kf. 4 1 or 2 or 3 501365 5 Sex Characteristics/ 52287 6 Sex/ 7632 7 Sex ratio/ 9049 8 Sex Factors/ 254781 9 ((sex* or gender* or man or men or male* or woman or women or female*) adj3 336361 (difference* or different or characteristic* or ratio* or factor* or imbalanc* or issue* or specific* or disparit* or dependen* or dimorphism* or gap or gaps or influenc* or discrepan* or distribut* or composition*)).tw,kf. 10 or/5-9 559186 11 4 and 10 24653 12 exp Antihypertensive Agents/ 254343 13 (antihypertensiv* or anti-hypertensiv* or ((anti?hyperten* or anti-hyperten*) adj5 52111 (therap* or treat* or effective*))).tw,kf. 14 Channel Blockers/ 36287 15 (calcium adj2 (channel* or exogenous*) adj2 (block* or inhibitor* or 20534 antagonist*)).tw,kf. 16 (agatoxin or or or or atagabalin or or 86627 azidodiltiazem or azidopamil or azidopine or belfosdil or or or brinazarone or calciseptine or or or or or columbianadin or or cronidipine or or deacetyl n nordiltiazem or deacetyl n o dinordiltiazem or deacetyl o nordiltiazem or deacetyldiltiazem or dealkylnorverapamil or dealkylverapamil or deutolperisone or or dexniguldipine or dexverapamil or diclofurime or or diperdipine or or dopropidil or or or elgodipine or elnadipine or or enecadin or or etripamil or or or or or or flordipine or flosatidil or fluspirilene or or furnidipine or or or iganidipine or isoperisone or or or lemildipine or or lifarizine or or or mepamil or mepirodipine or mesudipine or meta or or or modipafant or or n methylbepridil or n nordiltiazem or naltiazem or nexopamil or or or or or or or nisoldipine or or norgallopamil or or olradipine or omega agatoxin or omega conotoxin or or palonidipine or or or pinokalant or pontuc or or

Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open

or or ronipamil or sagandipine or semotiadil or or siratiazem or tamolarizine or teludipine or temiverine or or or trelnarizine or or watanidipine or xestospongin C or ).nm,tw,kf. 17 Calcium/ 263148 18 limit 17 to yr="1966-1967" 2861 19 Calcium/ai 1873 20 limit 19 to yr="1968-1981" 707 21 Channels/ 34899 22 limit 21 to yr="1979-1981" 1461 23 exp -Converting Enzyme Inhibitors/ 42827 24 (("Angiotensin-Converting Enzyme" or ACE) adj5 (inhibit* or antagoni*)).tw,kf. 37120 25 ("kininase ii" adj2 (antagoni* or inhibit*)).tw,kf,nm. 150 26 ( or altiopril or ancovenin or or benazeprilat or or 30970 ceranapril or or cilazaprilat or deacetylalacepril or or or or epicaptopril or fasidotril or fasidotrilat or foroxymithine or or fosinoprilat or gemopatrilat or idrapril or ilepatril or or imidaprilat or indolapril or libenzapril or or or moexiprilat or or pentopril or pentoprilat or or perindoprilat or pivopril or or or or ramiprilat or or s nitrosocaptopril or sampatrilat or or or or temocaprilat or teprotide or or trandolaprilat or utibapril or utibaprilat or vasopeptidase inhibitor or zabicipril or zabiciprilat or or ).nm,tw,kf. 27 Enzyme Inhibitors/ 129341 28 limit 27 to yr="1975-1987" 1738 29 exp Angiotensin Receptor Antagonists/ 22877 30 (angiotensin adj2 receptor adj2 (blocker* or antagonist*)).tw,kf,nm. 17015 31 ( or or or elisartan or embusartan or or 20235 or fonsartan or forasartan or or or milfasartan or or olodanrigan or pomisartan or pratosartan or ripisartan or saprisartan or sartan derivative or sparsentan or or or or zolasartan or irbesarten).nm,tw,kf. 32 Angiotensin II Type 1 Receptor Blockers/ 8428 33 limit 32 to yr="2004-2010" 5146 34 beta-blocker*.tw,kf,nm. 29516 35 ( or or or alprenolol derivative or or beta 1 72506 receptor blocking agent or beta 2 blocking agent or beta 3 adrenergic receptor blocking agent or bfe 55 or or or bromoacetylalprenololmenthane or or or or or or bunolol or or or or or or or or deacetylmetipranolol or dexpropranolol or or dichlorisoprenaline or or dilevalol or or

Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open

or or or falintolol oxalate or or hydroxybenzylpindolol or or iodopindolol or or or or or or or or mercuderamide or or or or or oberadilol or or or or or * or or prizidilol or or pronetalol or or proxodolol or or or soquinolol mucate or or or or or or or or or or trasitensin or trepress or tribendilol or viskaldix or or zoleprodolol or or or or fumarate or carteolol hydrochloride or tartrate or metoprolol succinate or penbutolol sulfate or solotol hydrochloride).nm,tw,kf. 36 exp / 78470 37 *.tw,kf. 38785 38 / 11727 39 (furosemide or frusemide or fursemide or frusemid or fusid or lasix or errolon or 16850 furanthril or furantral).nm,tw,kf. 40 ( or alilusem or amisometradine or ammonium acetate or bemitradine 61739 or besulpamide or brocrinat or or or epinine or ethoxzolamide or or ibopamine or or or mercaptomerin or mercumatilin or merethoxylline or or or or niravoline or agent or pamabrom or perhexiline or perhexiline maleate or sitalidone or skf 105494 or or theophylline or tiamizide or or tienoxolol or traxanox or triniton or tripamide or viskaldix or chlorthalidone or or or or hydrochloride or or or bisoprolol or bendrofluazide).nm,tw,kf. 41 exp Receptor Antagonists/ 9160 42 (antialdosteron* or anti * or spironolacton* or eplerenon* or canreno* or 12684 ((aldosterone* or mineralocorticoid*) adj3 antagonist*)).tw,kf,nm. 43 ( or apararenone or canrenoate or or 9903 or canrenone derivative or or or or or or mexrenoic acid or or or or ).nm,tw,kf. 44 Aldosterone/ 23836 45 limit 44 to yr="1966-1977" 4553 46 alpha?blocker*.tw,kf,nm. 32 47 ( mesylate or hydrochloride or hydrochloride).tw,kf. 208 48 .tw,kf,nm. 4633 49 Central agonist*.tw,kf,nm. 14 50 (alpha methyldopa or hydrochloride or acetate or 1228 hydrochloride).tw,kf. 51 (Peripheral adj2 adrenergic adj2 inhibitor*).tw,kf. 1

Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128 Supplementary material BMJ Open

52 ( or monosulfate or ).nm,tw,kf. 18266 53 (blood vessel dilator* or vasodilator*).tw,kf,nm. 68457 54 (hydralazine hydrochloride or ).tw,kf,nm. 2200 55 12 or 13 or 14 or 15 or 16 or 18 or 20 or 22 or 23 or 24 or 25 or 26 or 28 or 29 or 30 567100 or 31 or 33 or 34 or 35 or 36 or 37 or 38 or 39 or 40 or 41 or 42 or 43 or 45 or 46 or 47 or 48 or 49 or 50 or 51 or 52 or 53 or 54 56 11 and 55 3304 57 (Animals/ or Models, animal/ or Disease models, animal/) not Humans/ 4582726 58 ((animal or animals or canine* or cat or cats or dog or dogs or feline or hamster* or 2320147 lamb or lambs or mice or monkey or monkeys or mouse or murine or pig or pigs or piglet* or porcine or primate* or rabbit* or rats or rat or rodent* or sheep* or veterinar*) not (human* or patient*)).ti,kf,jw. 59 57 or 58 4970127 60 56 not 59 3117 61 (exp child/ or exp infant/ or adolescent/) not exp adult/ 1820849 62 (newborn* or new-born* or neonat* or neo-nat* or infan* or child* or adolesc* or 1433304 paediatr* or pediatr* or baby* or babies* or toddler* or kid or kids or boy* or girl* or juvenile* or teen* or youth* or pubescen* or preadolesc* or prepubesc* or preteen or tween).ti. 63 (pediatr* or paediatr*).jw. 551915 64 61 or 62 or 63 2368164 65 60 not 62 3045 66 limit 65 to (comment or editorial or letter) 35 67 65 not 66 3010 68 remove duplicates from 67 3006

Gasbarrino K, et al. BMJ Open 2020; 10:e036128. doi: 10.1136/bmjopen-2019-036128