Epithelia and Glands IUSM – 2016 I
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Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Epithelia and Glands II. Learning Objectives III. Keywords IV. Slides A. Epithelia 1. Simple a. Simple squamous b. Simple cuboidal c. Simple columnar d. Pseudostratified columnar 2. Stratified a. Stratified squamous b. Stratified cuboidal c. Stratified columnar d. Transitional B. Exocrine Glands 1. Simple (unbranched duct) a. Tubular b. Branched tubular c. Coiled tubular d. Branched acinar 2. Compound (branched ducts) a. Tubular b. Acinar c. Tubulo-acinar SEM of ciliated columnar epithelium of the uterine tube V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Epithelium II. Learning Objectives III. Keywords 1. Greek: epi – “upon”, thele – “teat, nipple” IV. Slides A. Epithelia 2. Avascular tissue that covers body surfaces, lines body cavities, and forms glands (endocrine and 1. Simple exocrine). a. Simple squamous b. Simple cuboidal 3. Composed of sheets of closely aggregated cells, of c. Simple columnar one or more layers thick, sitting upon a basement d. Pseudostratified columnar membrane. 2. Stratified 4. Creates a barrier between “external” environment a. Stratified squamous and underlying connective tissue. b. Stratified cuboidal c. Stratified columnar 5. Polarized with a free surface (apical surface), d. Transitional generally facing the external environment or lumen, B. Exocrine Glands and a bound surface (basal surface), facing the 1. Simple (unbranched duct) basement membrane. a. Tubular 6. Epithelial tissues are categorized by the number of b. Branched tubular cell-layers and the shape of their cells. c. Coiled tubular d. Branched acinar 7. Exocrine glands are categorized by the arrangement of their duct portion (branched or not) and the 2. Compound (branched ducts) shape of their secretory portions. a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction II. Learning Objectives Learning Objectives III. Keywords IV. Slides 1. Understand how epithelia are classified into simple, stratified, and A. Epithelia pseudostratified types and the usual functional significance of each 1. Simple type. a. Simple squamous b. Simple cuboidal 2. Recognize the (extracellular) basement membrane of epithelia, apical c. Simple columnar specializations such as the terminal web, and ultrastructural features d. Pseudostratified columnar of the various types of intercellular junctions. 2. Stratified a. Stratified squamous b. Stratified cuboidal 3. Understand that epithelium forms barriers and compartments by c. Stratified columnar covering and lining the body’s outer and inner surfaces. d. Transitional B. Exocrine Glands 4. Understand that epithelium is specialized for protection (or as a 1. Simple (unbranched duct) barrier), transport, absorption, and secretion. a. Tubular b. Branched tubular 5. Understand that glands are composed mostly of epithelial cell c. Coiled tubular aggregates clustered together to perform specific secretory and/or d. Branched acinar excretory functions and that there are two main types of glands: 2. Compound (branched ducts) exocrine and endocrine. a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction II. Learning Objectives Learning Objectives (cont.) III. Keywords IV. Slides A. Epithelia 6. Distinguish the basic differences between the parenchyma and 1. Simple stroma of a gland. a. Simple squamous b. Simple cuboidal 7. Understand that exocrine glands can be classified according to four c. Simple columnar features: the secretory portion’s shape (alveolar/acinar vs. tubular), d. Pseudostratified columnar the duct system (simple vs. compound), the nature of the secretion 2. Stratified (serous vs. mucous), and the mode of cell secretion (merocrine, a. Stratified squamous apocrine, holocrine). b. Stratified cuboidal c. Stratified columnar 8. Continue to appreciate how structure relates to function. d. Transitional B. Exocrine Glands 1. Simple (unbranched duct) a. Tubular b. Branched tubular c. Coiled tubular d. Branched acinar 2. Compound (branched ducts) a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction II. Learning Objectives Keywords III. Keywords IV. Slides Acinar Mucous A. Epithelia Apocrine Myoepithelial cell 1. Simple Branched tubular Non-keratinized a. Simple squamous Brush border PCCE b. Simple cuboidal Cilia Pseudostratified columnar c. Simple columnar Coiled tubular Serous d. Pseudostratified columnar Compound gland Simple columnar 2. Stratified Epithelia Simple cuboidal a. Stratified squamous Glands Simple epithelia b. Stratified cuboidal Glycocalyx Simple gland Goblet cells Simple squamous c. Stratified columnar Holocrine Stratified cuboidal d. Transitional Intercellular junctions Stratified epithelia B. Exocrine Glands Keratin Striated border 1. Simple (unbranched duct) Keratinized Terminal web a. Tubular Merocrine Transitional b. Branched tubular Microvilli Tubular c. Coiled tubular d. Branched acinar 2. Compound (branched ducts) a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Classifying Epithelium II. Learning Objectives III. Keywords 1. The initial classification of epithelial tissue is based upon the number of cell layers between IV. Slides the basement membrane and the apical surface: A. Epithelia a. Simple epithelia are only one cell layer thick; despite how it may appear, all the 1. Simple cells of simple epithelia are directly attached to the basement membrane. a. Simple squamous b. Simple cuboidal b. Stratified epithelia are more than one cell layer thick so that not all the cells are c. Simple columnar directly attached to the basement membrane; the apical layers of cells are attached d. Pseudostratified columnar to the cells below them, not the basement membrane. 2. Stratified 2. Next, epithelia are classified by the shape of the cells composing the tissue: a. Stratified squamous b. Stratified cuboidal a. The shapes may be classified as squamous, cuboidal, or columnar. c. Stratified columnar b. Since it is often difficult to see the actual shape of individual cells, generally the d. Transitional shape of the nucleus is used to determine the shape of the cell. B. Exocrine Glands 1. Simple (unbranched duct) c. For stratified epithelia, the shape of the cells may appear different between the a. Tubular basal layer of the cells and the more apical layers of cells; therefore, the most apical b. Branched tubular cell shape is used to classify the tissue. c. Coiled tubular 3. Finally, specific epithelia are distinguished by the presence of apical modifications such as d. Branched acinar microvilli, cilia, and stereocilia. 2. Compound (branched ducts) a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Slide 78: Eye, H&E II. Learning Objectives III. Keywords Slide Overview IV. Slides A. Epithelia 1. Simple a. Simple squamous iris retina b. Simple cuboidal cornea c. Simple columnar optic d. Pseudostratified columnar nerve 2. Stratified a. Stratified squamous lens b. Stratified cuboidal c. Stratified columnar d. Transitional B. Exocrine Glands look at the interior 1. Simple (unbranched duct) surface of the a. Tubular cornea to see an b. Branched tubular example of simple c. Coiled tubular squamous d. Branched acinar epithelium 2. Compound (branched ducts) a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Slide 78: Eye, H&E II. Learning Objectives III. Keywords IV. Slides A. Epithelia 1. Simple look here for simple a. Simple squamous squamous b. Simple cuboidal epithelium c. Simple columnar d. Pseudostratified columnar thick pink 2. Stratified line is the a. Stratified squamous basement b. Stratified cuboidal example of membrane c. Stratified columnar (nonkeratinized) d. Transitional stratified B. Exocrine Glands squamous 1. Simple (unbranched duct) epithelium a. Tubular b. Branched tubular c. Coiled tubular (air) d. Branched acinar 2. Compound (branched ducts) a. Tubular simple squamous epithelium consists of a single layer of flattened (squamous) cells; specialized types b. Acinar include endothelium (lines the interior of vessels and heart chambers) and mesothelium (lines the exterior of c. Tubulo-acinar certain organs and body cavities) V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Slide 45: Autonomic Ganglia, H&E II. Learning Objectives III. Keywords IV. Slides A. Epithelia 1. Simple a. Simple squamous b. Simple cuboidal c. Simple columnar simple d. Pseudostratified columnar squamous 2. Stratified epithelium a. Stratified squamous (endothelium) b. Stratified cuboidal c. Stratified columnar blood vessel d. Transitional B. Exocrine Glands 1. Simple (unbranched duct) a. Tubular b. Branched tubular c. Coiled tubular d. Branched acinar layers of 2. Compound (branched ducts) smooth muscle a. Tubular b. Acinar c. Tubulo-acinar V. Summary Lab 4 – Epithelia and Glands IUSM – 2016 I. Introduction Slide 14: Kidney, Masson Trichrome II. Learning Objectives III. Keywords Slide Overview IV. Slides A. Epithelia look in the cortex (outer region of an organ) to 1. Simple find renal corpuscles with Bowman’s capsule a. Simple squamous lined by simple squamous epithelium b. Simple cuboidal c. Simple columnar d. Pseudostratified columnar 2. Stratified a. Stratified squamous b. Stratified cuboidal cortex (outer) c. Stratified columnar d. Transitional B. Exocrine Glands medulla (inner) 1. Simple