Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production Sujie Ke, … , Anna Milanesi, Gregory A. Brent JCI Insight. 2021. https://doi.org/10.1172/jci.insight.149425. Research In-Press Preview Endocrinology Graphical abstract Find the latest version: https://jci.me/149425/pdf Thyroid Hormone Receptor Beta Sumoylation is Required for Thyrotropin Regulation and Thyroid Hormone Production Sujie Ke1,2, Yan-Yun Liu1, Rajendiran Karthikraj3, Kurunthachalam Kannan4, Jingjing Jiang1,5, Kiyomi Abe1,6, Anna Milanesi1 and Gregory A. Brent1 1 Division of Endocrinology, Department of Medicine and Department of Physiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90025 2 Present address: Department of Endocrinology, Union Hospital, Fujian Medical University, Fuzhou, Fujian 35001, China 3 Wadsworth Center, New York State Department of Health, Empire State Plaza, P.O. Box 509, Albany, New York 12201-0509 4 Department of Pediatrics and Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016 5 Department of Endocrinology, Zhongshan Hospital, Fudan University, Shanghai 200025, China. 6 Present address: Department of Pediatrics, Keio University School of Medicine Address; 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, and Tokyo Saiseikai Central Hospital, Minato-ku, Tokyo 108-0073 Correspondence should be addressed to GAB
[email protected] or YYL
[email protected]. Conflict of interest statement: The authors have declared that no conflict of interest exists. 1 Abstract Thyroid hormone receptor beta (THRB) is post-translationally modified by small ubiquitin-like modifier (SUMO). We generated a mouse model with a mutation that disrupts sumoylation at lysine 146 (K146Q) and resulted in desumoylated THRB as the predominant form in tissues.