Bupleurum & Tang Kuei Formula Xiao Yao Wan Free & Easy Wanderer Plus Formula Jia Wei Xiao Yao San

Bupleurum & Tang Kuei Formula (Xiao Yao Wan), and its most popular modification, Free & Easy Wanderer Plus ( Jia Wei Xiao Yao San), are the most commonly prescribed herbal formulas in the United States and Taiwan. The 900 year old classical formula, Bupleurum & Tang Kuei Formula (Xiao Yao Wan), comes from The Formulary of the Pharmacy Service for Benefiting the People in the Tai Ping Era (Tai Ping Hui Min He Ji Ju Fang) published in 1107. Both formulas are a modification of theShang Han Lun formula, Frigid Extremities Powder (Si Ni San), published nearly 900 years earlier. As is evident from the Modern Applications section below, these two formulas are among the most studied and versatile formulas in all of modern Chinese herbal medicine. General Indications Generally speaking, both these formulas are used to treat stress with an underlying spleen qi and blood deficiency. Because of the deficiency component, the stress is likely to become emphasized around menstruation, when less blood is available for circulation and for carrying the qi. Dysmenorrhea, PMS, and stress in general (for men and women alike) are the most common reasons for prescribing these formulas today. Children too, especially those who are under pressure to perform/ produce, benefit from taking these formulas. Stress will affect any areas of weakness, but particularly those ruled by the liver or middle burner. These include the chest, the abdomen, the entire digestive tract, and, of course, the blood, which is made in the middle burner and ruled by the liver. Altogether, the central role played by blood and digestion for the rest of the body accounts for the wide range of indications for which these two formulas are used. The chief difference between them is that Free & Easy Wanderer Plus ( Jia Wei Xiao Yao San) is preferred when there are heat signs such as irritability or redness of the eyes or tongue, or where chronic stress in the form of qi stagnation has developed into fire. Both formulas are well-balanced and can be taken for acute situations as well as long-term.

Chinese Medical Actions Bupleurum & Tang Kuei Formula Free and Easy Wanderer Plus 1. Harmonizes liver and spleen 1. Harmonizes liver and spleen 2. Strengthens spleen and smooths liver qi 2. Clears heat and cools blood 3. Nourishes liver blood 3. Invigorates blood and breaks up stasis 4. Frees constraint 4. Strengthens spleen and smooths liver qi 5. Nourishes liver blood 6. Calms shen Bupleurum and Tang Kuei Formula Ingredients Pinyin Latin English Percent of Formula Chai Hu (chief) Bupleuri Radix Bupleurum Root 16.1% Dang Gui (deputy) Angelicae Sinensis Radix Dong Quai, Tang Kuei Root 16.1% Bai Shao (deputy) Paeoniae Radix, alba Chinese White Peony 16.1% Bai Zhu (assistant) Atractylodis Macrocephalae Rhizoma White Atractylodes Rhizome 16.1% Fu Ling (assistant) Poria Poria, Hoelen, Tuckahoe 16.1% Zhi Gan Cao (assistant) Glycyrrhizae Radix Preparata Chinese Licorice Root, honey-fried 8.1% Gan Jiang (envoy) Zingiberis Rhizoma Dried Ginger 8.1% Bo He (envoy) Menthae Haplocalysis Herba Chinese Mint 3.3% Bupleurum and Tang Kuei General Indications / Modern Applications • Abdominal distension or • Bi-polar disorder • Climacteric states • Cold extremities with bloating • Bitter taste in mouth • Chest fullness (not from warm torso • Allergies, food • Breast distension phlegm- heat) • Colitis • Anemia, various types • Breast hyperplasia • Cholecystitis, chronic • Complexion, sallow • Anxiety, stress-induced • Breast lumps, • Chronic Fatigue • Constipation • Appetite, poor fibrocystic Syndrome (continued) Bupleurum and Tang Kuei Formula/Free and Easy Wanderer Plus Monograph © June 2016, Herbal Medicine Press Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 2 dose for acute conditions. for acute dose discretion up to 5tabs asingle in increasedbe at practitioner’s a chronic issue, but this can 3 times daily to gently correct The standardtablets, dosageis 2 D instead. Kuei Formula heat, use of pregnancy. In without cases signs Use with caution during C Wiry tight, or rapid. weak, or thin P pale. Red sides, may body red be or T • Calms blood liver • Nourishes and spleen • Strengthens breaks blood and • Invigorates blood cools and heat • Clears • FE conditions. for acute dose discretion up to 5tabs asingle in increasedbe at practitioner’s a chronic issue, but this can 3 times daily to gently correct The standardtablets, dosageis 2 D increase while taking this formula. disturbance digestive or irritability an) S Yao Wanderer Plus present, use When strong heat are signs C rapid.be Wiry or tight, thin or weak, may P the sides. on Pale body, slightly red, especially T • Frees constraint blood liver • Nourishes and spleen • Strengthens spleen and liver • Harmonizes BTK F ongue ongue ulse ulse Harmonizes liver and spleen and liver Harmonizes ontraindica ontraindica osage osage smooths liver qi liver smooths stasis up W P smooths liver qi liver smooths

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A c tions ) P • Bitter taste (more • Acne • Acid reflux stress- • Hypertension, • Hotflashes • Headache, dull • Hay fever, chronic • Fatigue, esp. after • Emotionalinstability • Edema • Dysmenorrhea mouth/throat • Dry • Dizziness • Diarrhea • Depression • Cramping, menstrual asthma • Cough, variant • Gastritis, chronic• Gastritis, • Fibromyalgia • Eyes, red • Dizziness, visual Same asBupleurum&TangSame Kuei Formula above, withtheadditionof: F ( B Formula Discussion Yi MuCao Yu Jin Zhi Zi Mu DanPi Chi Shao(deputy) CaoZhi Gan Fu Ling ZhuBai Shao Bai Dang Gui Chai Hu F All liver-spleen disharmonies involve(usually deficiency in some degreethe of spleen) the both these scope formulas of reaches far beyond the gynecological realm. evident from the thisin paper represent the two most popular modificationsin modern times. But,is as or bloodassociated deficiencywith menstruation. The two formulas discussion under itswell many as variants, are commonly to used treat disorders marked by qistagnation mony, and because women are especially susceptible to such disharmonies, this representative is the onemany of patterns of associated with aliver-spleen dishar for treating cold limbs when the stuck qiis the in torso, especially the in chest. Because The origin formula, FrigidExtremities Powder inyin continued intense thanfor BTK) induced menstruation ree ree upleurum (deputy) (deputy) &E &E l (assistant (assistant) (chief) (deputy) (deputy) (deputy) (deputy) (assistant) asy asy

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K e uei P P and and • Neurasthenia disposition • Nervous • Nausea swings • Mood irregular• Menstruation, pain • Menstrual symp • Menopausal • Lumbar pain, • Libido, low insufficient • Lactation, • Irritability • Insomnia • Infertility • Impotence pain • Hypochondriac • Irritability (more • Irritability • Indigestion Bowel • Irritable • Herpes, genital • Hepatitis, chronic G lus lus intense thanfor BTK) Syndrome (IBS) toms menstrual eneral Modern Applications G I

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Chinese White PeonyChinese White White Rhizome Atractylodes Quai, Dong Tang Kuei Root Bupleurum Root Hoelen, TuckahoePoria, Chinese Licorice Root, honey-fried Tree Peony RootBark Turmeric, Curcuma Tuber Gardenia Fruit Chinese Motherwort Chinese RedPeony nglish - tions sections in this sections in monograph, /M , a is % unintended • Weightloss, bleeding,• Uterine difficulty • Urinary • Stress • Stools, erratic interaction, • Social • PTSD • Premenstrual • Polycystic Ovarian • Palpitations cysts • Ovarian • Ulcers, pepticororal • Tremors rash, red • Skin • Shingles • Prostatitis, chronic • Pelvic inflammatory nointerest in Syndrome (PMS) Disorder (PCOD) /M odern disease dysfunctional Shang Han Lun Shang odern

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The strategy in this case would be simply to strengthen the the strengthen to simply thiscasebe would in strategy The it. as such formulas with spleen Pian) Tu (He Ta n g ) is so delicate that is a spleen of end continuum other the the for much be too to prove can function liver normal even that Powder), as mentioned above, but also but above, as mentioned Powder), Gan Wan) or burner, dle or the middle burner in general, causing chest fullness, flank flank fullness, chest causing in general, burner middle the or address that formulas The distress. digestive acute and/or pain, are etiology liver ofthe excess functions efficiently. functions efficiently. is a liver continuum disharmony of end liver-spleen one the At spleen the overtakes of liver the excess The excess. in extreme they are in the right relationship, the regulating function of function regulating the relationship, right in the are they spleen, the of blood into flow and qi a smooth keeps liver the transportation and transformation its perform to it allowing liver is supposed to control and help regulate the spleen, to to spleen, the regulate help and control to is supposed liver help tools gardening that way the smoothly, running it keep When fertile. and fresh aerated, debris, from soil free the keep based in as “ the which in one is liver and spleen between relationship The As with any formula that is defined by its ability to “harmo to ability its by is defined that formula any with As is of formulas two strategy these the organs, two any nize” and poor appetite. Free & Easy Wanderer Plus was a modifica Plus Wanderer & Easy Free poor appetite. and where disharmony liver-spleen the address to specifically tion developed. signs had heat other or irritability there is a tendency to congeal. Besides applications relating to to relating applications Besides congeal. to is a tendency there in pain treat used to originally were 2 formulas these menses, fatigue throat, and mouth dry hypochondrium, or flanks the balanced between excess and deficiency, and it includes herbs herbs it includes and deficiency, and excess between balanced from develop can that fire into a transformation address that stasis up where break that as as well herbs qi stagnation, the the underlying deficiency, which sets up the issues to become to become issues the up sets which deficiency, underlying the of The emphasis month. after month repeat to or chronic Plus Wanderer & Easy Free continuum of liver-spleen disharmonies, disharmonies, of liver-spleen continuum of emphasis the but excess, is primarily that a pattern Formula Kuei Tang & pleurum with some degree of excess (usually in the liver). On the the On liver). in the (usually of degree some with excess Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 4 in manyin formulas that treat cough.) Eventually, herbalists primarily agynecological as of herb, but it can found still be regular. (Ever since, angelica root gui) noticedperiods that when women took angelica root primarily to used rectify rebellious qi, especially cough. Later Before the thus recovering for it the ability to course the qismoothly. restores the suppleness to the liver by drenching it with blood, for the liver and the is taste intrinsic to the wood element. It to the liver. As asourflavored blood tonic, an affinity it has develops.is why This whitepeony and its coursing/regulating action interrupted: is stagnation from insufficient blood, it can no longerfunction smoothly its intrinsic suppleness, either due to congestion with toxin or allows it to function smoothly. When the liver loses some of we call it liver yin. It blood is that nourishes the liver and When the discussing blood that nourishes the liver to other the areas to body nourish of and support function. liver blood. blood”“Liver refers to the blood sent by the liver theliver The yin is of blood. functions it needs, above all, to remain supple, with ample yin. damp-heat.is In order for the liver to perform these any of toxin takes when discharged by the liver into the intestines detoxification process, by definition, is toxin; and the form (bile) and others defecated. be will The waste materialany of into the intestines where some substances re-absorbed be will The only twoingredients in alreadyhas transformed into fire. Jia Wei Xiao( Yao San) toois warm to included be in underlying weakness the in middle burner. But dried ginger Yao Wan) an envoyas in The fact thatdried ginger seenhere be also the as famous herb duo that relieves spasm. rice root formulas to is alleviate pain (especially cramps), prepared lico atractylodes areas from the drying properties bupleurum of and to engender fluidsin order to preserve theliver and other sweet. It functions these in two formulas to fortify the spleen The otherassistant, preparedlicorice root the dampness that encumbered has it, restricting its function. sweet. well as as It therefore “rescues the spleen” by drying up the ability to engender fluids, but atractylodes poria Atractylodes dispersedblood it is throughout as the body. nourishing it with blood) and to invigorate theliver flow of work with white peony therefore the utilized in two formulas under here discussion to layses its in ability to nourish and move blood the in liver. 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augment the formula’s ability to disperse clumps and reduce included to further the assist in invigoration blood and to of and calms (zhi zi) that may have become unsettled from the liver fire. Gardenia clears heat, and the even opens heart orifice quiet to and gallbladder into the action. It helps to course qiand blood, drains deficiency heat. Curcuma tuber an) S Yao tree utilized in root cortex the peony of tree, making three the peony parts of this advancing the pattern. stage of Mouton and helps to break up the clumping that to can occur at begin peony Free and Easy Wanderer Plus ing arole with the blood and heat components addressed by (Xiao Yao Wan) which do not appear in Wanderer Plus fiveingredients included in the version of ginger Easy WandererPlus Formula compared to self-care. creased an S Yao formulations. both Results of tion tests and field tests to ofobserve the theeffects herbal Wei Xiao Yao San to investigate the anti-anxiety actions of anxiety actions according to one study. A study conducted was Anxiety­­ using the Hamilton Depression BCX. Scale Rating sion. to effective be improvingat the and signs symptoms depres of sants alone. Results show that overall sants, and combined with antidepressants versus antidepres searched including dizziness, headache, mouth, dry constipation, or nausea. medications alone there were fewer associated side effectslike were combined with alone. noted,Also when Western anti-depressant medications sant medications, more was effective than the pharmaceuticals to placebo, and that when combined with western anti-depres pression. The study stated that it morewas effective compared effective herbal formulationin treating the symptoms de of meta-analysis. Results stated that disorders. 14randomized controlled trials were included the in overall effectiveness of Depression Emotional Modern Applications andses drain excess dampness through the urine. masses. It commonly is to used simultaneously regulate men of of Another systematic conducted was review to the assess effects Xiao Yao Wan Xiao Yao Wan (chi shao) (gan jiang)(gan clears heat and cools blood. It drains also damp-heat — showed prolonged interaction social time and in . It reduces swellings, settles liver fire, cools blood, and

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xi with and the most common addi Jia Wei Xiao Yao San Yao Xiao Wei Jia —Premenstrual dis dysphoric The results noted that there there that noted results The in a clinical observation study. study. observation in a clinical xvi Jia Wei Xiao Yao San Yao Xiao Wei Jia Xiao Yao Wan Yao Xiao 58 patients with dysmenorrhea were were dysmenorrhea with 58 patients xii — Xiao Yao Wan Yao Xiao —Dysmenorrhea is a common gynecological Jia Wei Xiao Yao San Yao Xiao Wei Jia with Premelle. with —An analysis was conducted encompassing over over encompassing was conducted analysis —An Zhi Bai Di Huang Wan Zhi Di Bai Huang with ’s ability to treat the symptoms associated with PMDD. PMDD. with associated symptoms the treat to ability ’s used prescription herbal common most second was the prescription of two herbal formulas included included formulas of herbal two prescription San tion included is syndrome climacteric transition, menopausal the During head sweats, night flashes, as hot presenting common, quite study A etc. irritability, anxiety, depression, insomnia, aches, manage to therapies alternative analyze to was conducted compared study The symptoms. signs and menopausal San Yao Xiao Of the 58 cases, 28 were between the ages of 13 and 18, 25 of ages 18, the between 13 and 28 were Of 58 cases, the between 5 cases were and of ages 24, the between 19 and were mini a for dysmenorrhea casesAll had of ages 30. the 25 and to two starting administered were Herbs ofmum months. six to two stopped were Herbs menstruation. to prior days three was for course Treatment disappeared. pain after days three 27 cases showed Results cycles. menstrual consecutive three pain with 29 cases improved of pain, recurrence no with cured pain no 2 cases showed and of pain, recurrence with but relief, was 96.55%. rate effectiveness Total improvement. MenstruationIrregular 22 Of 50 patients, the 50 cases of menstruation. treat irregular 18 cases were menstruation, diagnosed as delayed cases were diagnosed cases 10 were and menstruation, diagnosed as early blood for added were Modifications as menstruation. irregular showed Results stagnation. liver and qi deficiency, pain, stasis, 4 and improvement, 15 cases showed cured, 31 cases deemed rate of 92%. effectiveness total a with effect, no cases showed Menopause the determine to 15,000+ patients for 54,000 prescriptions used products Chinese herbal prescribed commonly most Taiwan. in menopause treat to considered and formula herbal prescribed commonly most co- common most The condition. this for formula core the order (PMDD) appears as severe depression, irritability, and and irritability, depression, as severe appears (PMDD) order more are Symptoms menstruation. to prior in women tension, (PMS). syndrome premenstrual seen with those than severe efficacy see the of to was conducted Research San six for formula herbal the with treated were 30 patients global and scale rating depression Hamilton cycles. menstrual to after and before done of were assessment tests functions efficacy good showed results The effectiveness. determine complete of 46.7% reporting with PMDD treatment the for no having 23.3% and improvement, showing 16.7% remission, of rate 63.4%. effectiveness an change; Dysmenorrhea that showed search database A condition. San to dysmenorrhea. treat modified given Results showed that vascular age decreased significantly after after significantly vasculardecreased age that showed Results continuedandthroughout thethree months. the first month, ofwere PMSsymptoms signs and improvement Significant of as a result using noted Premenstrual dysphoric disorder ------

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at high doses reversed behav reversed doses high at —A review of—A Chinese herbal was studied to determine its ef its determine to was studied Jia Wei Xiao Yao San Yao Xiao Wei Jia Jia Wei Xiao Yao San Yao Xiao Wei Jia Xiao Yao Wan Yao Xiao Jia Wei Xiao Yao San Yao Xiao Wei Jia could relieve stress-associated behavior behavior stress-associated relieve could group. A study, with the aim of the the with examining study, A ix —A clinical trial was conducted in the treat in the was conducted trial clinical ­—A was the most commonly prescribed herbal herbal prescribed commonly most was the Jia Wei Xiao Yao San Yao Xiao Wei Jia

Jia Wei Xiao Yao San Yao Xiao Wei Jia vii Jia Wei Xiao Yao San Yao Xiao Wei Jia —According to one study, to one study, —According — prior to treatment and at the one and three month markers. markers. month three and one the at and treatment to prior questionnaire. was a self-assessment evaluation The second efficacy of evaluating Two months. three for 45 patients to ministered was measured evaluation age Vascular used: were methods Xiao Yao San Yao Xiao premenstrual for (37.5% of prescriptions) all herbal formula (PMS). syndrome Gynecological / Menstruation Gynecological (PMS) Syndrome Premenstural that 1998-2011 showed during Taiwan in medicine behavior and marked cognitive impairment. Repeated treat Repeated impairment. cognitive marked and behavior ofments of that animals. unexposed to similar symptoms ioral Jia Wei Xiao Yao San Yao Xiao Wei Jia single enhanced various to exposed were animals The in rats. anxiety-like pronounced creating paradigms stress prolonged sesses anxiolytic and cognition-improving effects and may may and effects cognition-improving and sesses anxiolytic disorder stress of post-traumatic treatment the be useful for whether determine to conducted was study This (PTSD). animals. PTSD behavior. The tests were repeated again after the administra the againafter repeated were tests The behavior. oftion of doses high of that unexposed to similar patterns behavior reversed prolonged stress paradigm; after which they were observed observed were they which after paradigm; stress prolonged maze water Morris and test, maze elevated test, in open field anxious and impairments cognitive animals The marked test. Stress was study The behavior. stress-associated reduce to fectiveness single enhanced an to exposed were that rats using conducted cian should be used when combining herbs and/or Western Western and/or herbs combining be used when should cian can as they (Tegretol) Carbamazepine with medications levels. Carbamazepine decrease or increase incidence of dizziness, blurry vision, rash, and nausea with the the with nausea and rash, vision, blurry of dizziness, incidence alone. Carbamazepine to compared co-treatment physi Western a by adjustment dosage and Close monitoring clinical response was significantly higher than carbamazepine carbamazepine than higher was significantly response clinical While alone or placebo. was increased there that was it noted reactions, adverse tional tion with Carbamazepine (Tegretol). This combination may may combination This (Tegretol). Carbamazepine with tion showed results The patients. bipolar for be a useful therapy the bipolar-depression and bipolar-mania treating when that Bi-polar Disorder using of disorders ment bipolar Jia Wei Xiao Yao San Yao Xiao Wei Jia while milder, were occur did that events the and events adverse Mirtazaprine. to efficacy a similar having alized anxiety and improved sleep quality. The total effective total The quality. sleep improved and alized anxiety improvement significant showing groups both with rate ness the for 79.54% and group Mirtazaprine the was for 83.27% depressant / anti-anxiety drug Mirtazaprine. The study lasted lasted study The Mirtazaprine. drug / anti-anxiety depressant sleep Several groups. two into patients 87 dividing weeks, five gener treating efficacy of show to performed were quality tests Another study compared studyAnother compared Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 6 diagnosed withdiagnosed infertility due to liver stagnation. Accompany pregnancy, but unable to conceive currently. All women were weresecondary definedas infertility, as defined ahaving prior unableas to conceive for greater than one year, and 11cases treated. were 14cases primary infertility, as diagnosed defined tility. 25patients 22through between the ages of 39 were Infertility group. control rate 93.3%for was the treatment group and 86.7%for the fivewith a total of courses prescribed. The total effectiveness hydroquinone ointment. 15days one was treatment, course of Wei Xiao Yao Sa Eand C. vitamin tion The treatment of group given was a and control group. Both groups were given oral administra tion pattern. The patients weredivided into a treatmentgroup on 60patients with chloasma with diagnosed liver qistagna usually on the face. A clinical efficacy studywas conducted and manifests large as brown patchy pigmentation changes, that occurs due to ahormonal change, pregnancy, seenin as Chloasma treatment PCOS. of usingterm modified effects of theand for only cases 19.44%of control group, noting the long cycles remained the for cases at 43.24%of the treatment group three cycles after stopping treatment, normalized menstrual control group at 54.05%and 58.33%respectively. Observing al cycle roughly was equal between the treatment group and three menstrual cycles. After treatment, menstru regulation of Diane-35, apharmaceutical. Treatment course consisted of Jia Wei Xiao Yao San control group. The treatmentgroup prescribedwas modified groups: the in 37cases treatment group the and in 36cases PCOS broken The study observed 73 of cases intodown two liver stagnation of diagnosis and blood heat.cine (TCM) drome when there (PCOS) a was Traditional Medi Chinese arecent in used was study to address polycystic ovary syn Syndrome Ovary Polycystic treatment group and 83.3%for the control group. ics. The results showed a total effectivenessof 98% ratefor the San treatment 50patients group of treated with J conducted on 98patients who were randomly divided into a ovaries, fallopian tubes, etc. A clinical observation study was serious condition resulting irreversible in damage to the uterus, (PID), the an infection female of reproductive organs, can a be InflammatoryPelvic Disease for patients with marked psychological symptoms. symptoms. The authors noted that especiallyit was beneficial fective for 33patients, decreasing both physical and emotional Xiao Yao San Another study conducted was with 45patients taking ation rate due to the adverse effectsassociatedwith Premelle. toms. Premelle, both as effectively alleviated most menopausal symp nowas significantdifference between and acontrol 48patients group of treated with antibiot Jia Wei Xiao Yao San —Modified —Chloasma (melisma) atemporary is —Chloasma skin condition for four weeks. The results showed that ef it was xx

n topical mask. The controlgroup given was xix and the control group prescribed was Xiao Yao Wan

—Modified —Pelvic Inflammatory Disease , however, had alower discontinu Jia Wei Xiao Yao San was used to used was treat infer Jia Wei Xiao Yao San Jia Wei Xiao Yao San ia Weiia Xiao Yao viii xvii for the

Jia Wei - Jia Jia - - and and ------cyst sizes ranged from the 3.0x3.6cmto the smallest of largest qi stagnation. The patients rangedagesin from 21 to 45. The ovarian of cysts.cases Patients had a liverTCM of diagnosis Ovarian Cysts— and duration headache, of and eight had cases no change. the year, had 11cases effective withresults reduced symptoms provement with resolution symptoms, of but relapsed during toms without recurrence for one year. marked 35cases im 14 days. were 42cases deemed cured, with resolution symp of rising, blood stasis, and qistagnation. Treatment course was tions were made for blood deficiency, qi deficiency, liver yang were treated with modified Headaches Menstrual herbal formula for treating breast cancer. that breast cancer conducted was in Taiwan. The results showed Breast Cancer­ ment; atotal effectiveness 95.83%. rate of showed improvement, and had 2cases little or no improve three menstrual cycles were 24cases deemed cured, 20cases after menstruation, and small, hard, cord-like nodules. After included breast pain and tenderness that worse was before and werecases confirmed by mammogram. Common symptoms ly 80%were atypical as diagnosed lobular hyperplasia. All were treated with amodified version of condition.ous In arecent report, breast hyperplasia of 48cases abnormallation of breast cells and considered is aprecancer Breast Hyperplasia noted on saliva testosterone concentrations. prolactin concentrations declined significantly. No change was In addition, saliva estradiol, saliva progesterone, and plasma absorption proliferation of the 51cases. 21out in of masses an overallwas effectiveness 96.1%,ratewith of x-rays showing g n Ta with combination in three month clinical trial conducted was using cific in cells the breast andis a risk factor for breast cancer. A non-cancerous condition defined increasedby growth spe of Breast Disease— Proliferation Breast 94.44%. cyst.of Two were cases deemed invalid. The total efficacy was were effectivewith clinical symptoms relieved and a reduction clinical and signs symptoms and cyst disappeared. Three cases treatmentof included cured, 28cases with disappearance of 5.2x6.8cm.of Treatment course 20days. was The outcome cured, four were deemed effective, and two wereinvalid. In the secondary infertility 11, group of five were deemed deemed cured, five were deemed effective, and was one invalid. In the primary infertility 14patients, group of eight were nation signs, but not pregnant, and invalid- no improvement. stagnation and signs pregnant, effective- no littleor liver stag irritability. Treatment efficacywas defined as: cured- no liver abdominal pain, cramps during menstruation, depression, and ing and signs symptoms included: PMS, breast tenderness, Jia Wei Xiao Yao San )for the treatment breast proliferation of disease. There

xxiii

—An herbal analysis Chinese products of for Modified —Breast hyperplasia describes the accumu —96 patients with menstrual headaches Citrus and Pinellia Formula Xiao Yao Wan was the was most frequently prescribed Xiao Yao Wan Breast proliferation a is disease Xiao Yao Wan was used to used was treat 36 xxvi xxv . modifica Primary

xxiv Jia Wei Xiao Yao

Xiao Yao Wan ( Er Chen Er Chen . Rough xxi xxii

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was used to treat treat was used to xxxv

shows significantshows on chronic liver in liver chronic on was used in the was used in the xxxvii was used to in a study in a study was used to , were the most effective effective most the were , rats to have improved behav improved have to rats Jia Wei Xiao Yao San Yao Xiao Wei Jia Xiao Yao Wan Yao Xiao to treat hepatitis B. 32 patients 32 patients B. hepatitis treat to was shown to inhibit liver fibro liver inhibit to was shown

Xiao Yao Wan Yao Xiao Xiao Yao Wan Wan Yao Xiao xxxiv can be an effective treatment strategy strategy treatment be effective an can

Modified Modified to be effective for chronic prostatitis with prostatitis chronic for be effective to Jia Wei Xiao Yao San Yao Xiao Wei Jia xxxii for 45 days. General activity, ALT, AST, AST, ALT, activity, General 45 days. for Xiao Yao Wan Yao Xiao —

Jia Wei Xiao Yao San Yao Xiao Wei Jia xxxiii ­— . Main symptoms included fatigue, abdominal fatigue, included symptoms Main . —A retrospective study cohort was conducted on —A study was conducted to observe the clinical ef clinical the observe to was conducted study ­—A Chai Hu Shu Gan Tang Shu Gan Chai Hu Xiao Yao Wan Wan Yao Xiao Jia Wei Xiao Yao San Yao Xiao Wei Jia Jia Wei Xiao Yao San Yao Xiao Wei Jia Xiao Yao Wan Yao Xiao

jury were investigated. Rat models of chronic liver injury were were injury Rat liver of models chronic investigated. jury were given MDA, SOD, and serum levels, HyP T-BIL, A/G, ALB, TP, observed. were homogenate, in liver activities GSH-PX ChE, found results The T-BIL, A/G, ALB, TP, AST, ALT, reduced ior and activity, ChE, MDA, of activity increased SOD, and serum levels, HyP that concluding GSH-PX, actionprotective on liver chronic injury. pain and distention, poor appetite, and hypochondriac pain. pain. hypochondriac and poor appetite, distention, and pain treat after and before also conducted were tests function Liver courses two to One month. was one course Treatment ment. nine cured, deemed 13 were Of 32 patients, the given. were effectiveness a total case; in one change no and cases improved, 29 of with was 90.6%, rate normalization ALT of 96.9%. rate 32 cases normalizing. the Cancer­ Liver combination the whether determine to patients cancer liver survival affected treatment cancer conventional with TCM of The TCM. used 25% of Close 127,237 patients to the rate. associated were TCM used who patients that showed study improve may TCM that of and risk a decreased death with patients. cancer in liver survival closely by survival. improved with associated formulas Liver Support given were Rats effects. hepatoprotective its investigate to inducing hepatitis chronic and hepatic dimethylnitrosamine, fibrosis. the to attributed partially are effects anti-fibrotic These sis. peroxidation. lipid inhibit to ability Chinese formulas effectsof Hepatoprotective provement. Two cases showed no significant improvement. significant no cases showed Two provement. Prostatitis Chronic ranged ages Patient of prostatitis. 60 cases oftreatment chronic 17 prostatitis. chronic diagnosed with were and 21-73 from improve marked 21 cases showed cured, deemed cases were cases had three and improvement, some cases 19 showed ment, showing rate of 95%, effectiveness total was a There effect. no San Yao Xiao Wei Jia examina fluid prostatic and of symptoms clinical improvement treatment. after tion Liver Disease— Liver Fatty Observa of study 86 patients. disease in liver a research fatty tion of liver blood function, lipid symptoms, and levels, liver effective total a showed results The imaging was performed. improved, function liver and Symptom of 95.35%. rate ness showing liver. fatty for Hepatitis B ficacy of modified with treated B were hepatitis chronic with San Yao Xiao - - - , - - - for - - dan Jia Wei Wei Jia to treat treat to Jia Wei Xiao Xiao Wei Jia shi changpu

xxx xxix , and modified with Jia Wei Xiao Yao San Yao Xiao Wei Jia Xiao Yao Wan Yao Xiao . Patients were aged 22 aged were Patients . . Of the 123 patients, ages ranged ranged ages Of 123 patients, . the Xiao Yao Wan Yao Xiao Xiao Yao Wan Yao Xiao —98 cases of retrograde ejaculation were were ejaculation —98 cases of retrograde —30 cases of hyperprolactinemia were ob were —30 cases of hyperprolactinemia A population-based study was conducted was conducted study population-based A , with additions for qi deficiency, heat, and and heat, qi deficiency, for additions with , xxvii Xiao Yao Wan Yao Xiao

with fluorouracil, doxorubicin, and and cyclophos doxorubicin, fluorouracil, with

—A clinicalobservation of xxviii was the most commonly prescribed herbal formula in formula herbal prescribed commonly most was the was used in combination with chemotherapy in the treat in the chemotherapy with was used in combination Xiao Yao Wan Yao Xiao were deemed cured. Of the 85 cases, 38 cases were cured in the in the cured 38 cases Of were cured. 85 cases, deemed the were the and month, second the in cured caseswere 32 month, first im 11 cases showed months. two following in the remaining confirmed with lab tests. The formula was a modified version version modified was a formula The tests. lab with confirmed of cases 85 wasmonths. 1-4 course treatment The stasis. blood treated with modified treated sperm no with ejaculation include Clinical symptoms 47. to casesAllwere wascloudy. intercourse after urination first and seven showing “improvement”, and 9 “invalid.” 9 and “improvement”, seven showing Retrograde Ejaculation ment” was defined as penile erections, but unable to perform to perform unable but wasas defined penile erections, ment” Results change. significant no marks “Invalid” activity. sexual improvement”, “marked 20 with “recovery”, 87 cured/ showed given. “Recovery” was defined as satisfactory penile erections erections penile was defined as satisfactory “Recovery” given. was defined as improvement” “Marked life. sex a normal and “Improve having difficulty sex. with stiffness erectile improved from 21-54. 56 cases were under 30, 52 cases were from 31- from 52 cases were 30, under 56 cases were 21-54. from TCM A old. 41 years over 15 cases were and of age, 40 years was deficiency kidney with diagnosis of qi stagnation liver Impotence 123 cases of dysfunction erectile was conducted. impotence used modified deemed cured; 5 cases showed improvement; 3 cases had no no 3 cases had improvement; 5 cases showed cured; deemed rate of 90%. effectiveness total a with effect; Health Men’s three months. Treatment results showed significant improve significant showed results Treatment months. three as levels serum prolactin reduce to ability formula’s in the ment 22 cases were symptoms. signs and clinical the aswell improve Hyperprolactinemia given were Patients served. fu xiang xi, shengshen, huang, niu di lan, ze Yao S an the study. endometrial cancer. The group of patients that used the combi the used that of The patients group cancer. endometrial a had Chinese with herbs in conjunction Tamoxifen ofnation cancer. endometrial of risk decreased subsequent on breast cancer patients in Taiwan that were treated with with treated were that Taiwan in patients cancer breast on in order formulas Chinese herbal without and with Tamoxifen Tamoxifen-induced of factor risk developing the determine to when combined with western chemotherapy, can be effective to be effective can chemotherapy, western with combined when prolong and symptoms, clinical improve quality oflife, address survival. patient 100% for the treatment group and 87% for the control group, group, control the 87% for and group treatment the 100% for group treatment the was 3% for rate recurrence the and group. control the 23% for to compared group and 57% in the control group. Adverse reactions were were reactions Adverse group. control 57% in the and group 10% compared at group treatment in the down dramatically was rate survival treatment The group. control in 80% the to phamide. The control group only used the western medica western the used only group control The phamide. in quality improvement significant showed results The tions. of treatment the rate 97% in effectiveness of a total with life ment of patients with breast cancer. 60 patients were divided divided were patients 60 cancer. breast with ofment patients used group treatment The of groups 30 each. two into San Yao Xiao San Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 8 diagnosis of liver and of stomachdiagnosis heat were treated. Patients were ulcers. with diagnosed stomach 114 cases ulcers and an OM an S Yao Ulcers Stomach symptoms 5days. was The recurrence rate 6%. was effectiveness 96%.rate of The averagetime of forelimination endoscopy. Two patients showed no change. There a was total epigastric pain,of reduced attacks, number of and improved and anormal endoscopy. Eight patients showed improvement patients were deemed cured, from with relief epigastric pain gastritis, with the ability to quickly relieve symptoms. 38 Jia Wei Xiao Yao San were confirmed by endoscopy. The study showed thatmodified reflux, nausea, and vomiting for more than 4 weeks. All cases pain, abdominal bloating,included belching, heartburn, acid Wei Xiao Yao San modified giving conducted formulas. herbal was A study lining, chronic known as gastritis, can treated be with Chinese Chronic Gastritis group. 83.33%for theof treatment group and 40%for the control 63.33% for the control group. And long term effectiveness rate total effectiveness 93.33% ratefor theof treatmentgroup and treatmentof eight was weeks. The results showed short term group receiving agastroprokinetic pharmaceutical. The course group receiving into atreatment group and control group, with the treatment constipation IBS- ment of predominant. 60patients were split nation with of showed efficacy the Another study the treatment group and 62.5%for the control group. medications. The results showed of91.6% a for total efficacy control 26patients group of given was Western anti-diarrheal treatment group take the herbal formula for four weeks. The diarrheaIBS- predominant. The study had 36 patientsin the One study observedofmodified the efficacy reactions. adverse report effective for IBS. notedAlso was that most studiesdid not and symptoms IBS. Basedon of the analysis, this formula is more effective than other medications for treating the signs Jia Wei Xiao Yao Sa included 17trials and 1,542patients. The results showed that the treatment irritable of bowel syndrome (IBS). The study to evaluate the efficacyof and safety SyndromeIrritable Bowel myoelectrical the patients. activity of gastric and motility gastric abnormal the of adjustment and evaluation. The outcome showedimprovement symptoms of were by assessed EGG(electrogastrography) and symptom ing. The studyused 20 patients with functional dyspepsia who or upper epigastric area that occurs during or right after eat dyspepsiaindigestion, definedas is mild in pain the abdomen patients with functional dyspepsia studied. was Functional Dyspepsia Functional Digestion xli xli in combination with with combination in

Si Mo Tang —A study was conducted using using conducted was study —A Xiao Yao Wan —Swelling or inflammationthe stomach of to 48patients. Chronic gastritis symptoms n had alower recurrence rate and was —The effect of was an effective was treatment for chronic (Four Milled Decoction) for the treat —A meta-analysis was performed performed was meta-analysis —A xxxix

Zuo JinZuo Wan plus plus Si Mo Tang Jia Wei Xiao Yao San Jia Wei Xiao Yao San xxxviii Xiao Yao Wan

to treat stomach Xiao Yao Wan Jia Wei Xiao and the control xlii in combi in

xl

Jia Jia on on for for for for - - - The resultsindicated a95% effectiveness rate, with cases 22 therapy and the control group using only the pharmaceutical. two 40, groups of the treatment group using the combination controlledized study. The studyused 80 patients brokeninto for used was the treatment ulcerative of colitis arandom in Colitis Ulcerative months for the control group. ment group; and 20.8%after six months and 29.2%after 12 5.4% after six months and 8.9%after 12 months for the treat rence rate between the two groups statistically was different: roughlywas the same between the two groups at 65%. Recur some improvement, and had 4cases no effect. Hp eradication cured; showed 15cases marked improvement; showed 13cases ment. In comparison, the control group had deemed 25cases marked improvement, and one showed case some improve deemed cured with no clinical symptoms; showed 16cases months. In the treatment 57patients, group of were 40cases treatmentof four was weeks. Patients were followed for 12 stool, red tongue with yellow coat, pulse. and awiry Course epigastric pain, irritability, acid reflux, fever, yellowurine, dry patients were positive for H. pylori (Hp). Symptoms included a control group treated with omeprazole. the 90%of Over broken into atreatment group treated herbs with Chinese and cant reduction tremors of after administration of eight patients exhibiting tremors. The results showed signifi tion-induced Parkinsonism. The herbal formulagiven was to San Tremors no improvement, with atotal effectiveness 90%. rate of sleep; showed 7cases some improvement, and showed 4cases creased sleep time by at least 3hours and with increased deep sleep time; had 10cases significantimprovement, with in pation. were 19cases deemed cured, with areturn to normal insomnia, irritability, easily upset, thirst, red eyes, and consti liver qistagnation with fire.Clinical manifestations included characterized insomnia of by40 cases a TCM of diagnosis Insomnia Other deemed ineffective,withas total effectivenessof 93%. rate showedcases improvement symptoms; in and five werecases effective,be with symptomsremission of for six months; 22 with remission symptoms of for one year; showed 23cases to appetite.loss of the 78cases, were Of 28cases deemed cured, epigastric burning sensation, acid reflux,belching, nausea, and ing and signs symptoms that included abdominal distention, ups at six months and one year. Patients had accompany cholecystitis. treatment Course of four was weeks with follow with mation, often caused bystones. gall repeated attacks the gallbladder, of characterized by inflam Chronic Cholecystitis— improved,12 cases and deemed 13cases not effective. rate 67.5%for the of control group, which had cured, 15cases treatment group. This was compared to a total effectiveness cured, improved, 16cases and not effective forin two thecases ’s ability to reduce tremors due to antipsychotic medica Ban Xia Xie Xin Tang

—A study was conducted to evaluate evaluate to conducted was study —A — Jia Wei Xiao Yao San — Xiao Yao Wan Chronic cholecystitis definedas is , treated chronic of 78cases xliii

was used in astudy in used was treating combined with Mesalazine Xiao Yao Wan Jia Wei Xiao Yao Jia Wei Xiao , combined xliv xlvi

-

- xlv - - - -

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liii Xiao Yao Yao Xiao were added. chen pi, ban huang qin and nu zhennu zi to treat 92 cases of treat to Tao Hong Si Wu Tang Wu Si Hong Tao was used to treat 40 cases treat was used to to treat migraine head migraine treat to , and

lv

lviii Xiao Yao Wan Yao Xiao yin yi bai, chen yi huang ren hao, combined with ­—A clinical observation study was con —A study was conducted to determine

lvii —A study was conducted to investigate the ef Jia Wei Xiao Yao San Yao Xiao Wei Jia Jia Wei Xiao Yao San Yao Xiao Wei Jia

lvi —

liv were made dependent upon diagnosis. For wind- For diagnosis. upon dependent made were Xiao Yao Wan Yao Xiao were added. For phlegm and blood stasis, stasis, blood and phlegm For added. were pi pa ye, sang bai pi, mu dan pi, pi, zhi dan bai pi zi, mu pa ye, sang —86 cases of acne were treated with modified modified with treated —86 cases of were acne . Patients were identified by TCM of diagnosis wind-heat, by identified were Patients . cases showed no improvement. The total efficacy of the treat efficacytotal the The of improvement. no cases showed was 97.7%. ment Headaches Migraine using ducted 20 for formula herbal the administered were 49 patients aches. with cured, 22 cases were of course treatment the After days. improvement, 24 cases showed of headache; disappearance with duration some shortened, and headache frequency relief, effec total The change. no cases showed three and lessened; was 89.3%. rate tiveness Yao Wan heat, damp-heat, For added. haung gui, dang yi cao mu kuxia, xia cao, 66 given. courses three with days was ten course Treatment im marked cases showed ten cleared; acne their cases had cases eight of acne; the 80% improvement with provement, two and of acne; the 50% improvement with improved were total effectiveness rate of rate 96.9%. effectiveness total Pharyngitis Chronic efficacythe of modified chronic diagnosed as simple 81 cases were pharyngitis. chronic pharyngitis. hypertrophic 11 cases as and chronic pharyngitis and swelling, pain included and itchiness, throat Symptoms of Course throat. in the body stuck ofa sensation a foreign was follow-up effect a statistical and days was ten treatment cured; deemed 43 cases were months. three after performed some and swelling had still but improvement, 47 cases showed rate effectiveness total the invalid; cases were two and pain; was 97.8%. Acne Wan to Additions stasis. blood and phlegm and damp-heat, from fibromyalgia for a minimum of five months. The results The ofmonths. a minimum for five fibromyalgia from im marked cases six showed cured; 16 cases were that showed improve some cases showed three condition; in the provement change. no cases had two and condition, in the ment UlcersOral ul aphthous as also known recurrent ulcers, oral of recurrent six at up a follow with weeks, was two course Treatment cers. cured deemed caseswere 34 that showed results The months. months. six after recurrence no and pain, no ulcer, healed with occurred; Relapse improvement. marked cases showed Four cases Two lessened. were of number recurrences the however, effective total was a 95% There changes. significant no showed rate. ness Hyperlipidemia fect of were group treatment in the 64 patients hyperlipidemia. treat triglycerides, cholesterol, Total combination. herbal this given and decreased, significantly were levels cholesterol LDL and signs accompanying Additionally, increased. cholesterol HDL insomnia, tinnitus, and palpita like headache, and symptoms, cured; deemed 87.5% were Of 64 cases, the improved. tions a with effect; no 3.1% had and improvement; 9.4% showed -

------Jia

xlvix Xiao Yao Yao Xiao

l xlvii Jia Wei Xiao Xiao Wei Jia Xiao Yao Wan Wan Yao Xiao Xiao Yao Wan Yao Xiao Jia Wei Xiao Yao San Yao Xiao Wei Jia with effect. no (PDAP)— PDAP is de PDAP (PDAP)— can effectively shorten the the shorten effectively can —A combination of

taken in conjunction with Metformin. Metformin. with in conjunction taken xlviii li ­—A clinical study using was used to treat 32 cases of chronic fa 32 cases of treat was chronic used to Jia Wei Xiao Yao San Yao Xiao Wei Jia with satisfactory results. Of the 27 cases, Of 27 cases, the results. satisfactory with Jia Wei Xiao Yao San Yao Xiao Wei Jia —A study in the treatment of zoster herpes treatment in the study —A —27 cases of fibromyalgia were treated with with treated were —27 cases of fibromyalgia

lii Xiao Yao Wan Yao Xiao —52 patients with type 2 diabetes were treated with with treated were type with 2 diabetes ­—52 patients , and the control group who were prescribed acyclovir. acyclovir. prescribed were who group control the and , . Five of the eight patients, 62.5%, showed improve showed 62.5%, patients, of eight the Five . to have a total effectiveness rate of 90%. A 73.33% rate rate A 73.33% of rate 90%. effectiveness a total have to Sheng San Mai Fibromyalgia San Yao Xiao Wei been suffering casesAll had female. 23 were and male 4 were significant improvement in FAS score from before to after after to before from score FAS in improvement significant treatment. tigue syndrome. Treatment course consisted of with weeks two consisted course Treatment tigue syndrome. was used to Scale (FAS) Assessment Fatigue total. courses two with rate was 87.5% effectiveness total The efficacy. determine course of zoster. course herpes Syndrome Chronic Fatigue and group and control group, with the treatment group leaving 18 leaving group treatment the with group, control and group group control the and herpes zoster significant with patients 14 cases. with the cure rate was 52.5% for the treatment group and 37.8% and group treatment the was 52.5% for rate cure the there weeks third and second the After group. control the for treatment the between efficacy in difference significant was no Yao S an time, crusting time, stop blistering for observed were Patients 1 week After time. recovery and relief, of pain length for time Herpes Zoster Herpes two into divided were 302 patients in which was conducted prescribed were who group, a treatment groups: in symptoms and shortened time between onset and disap onset and between time shortened and in symptoms significant have to formula this indicating of cough, pearance asthma. variant cough treating for effect therapeutic sociated with traditional asthma. The study showed showed study The asthma. traditional with sociated Wan improvement significant with effective markedly was deemed asthma is a form of asthma with the only symptom being a being symptom of only the is with a form asthma asthma as wheezing the without usually cough, non-productive dry, administration of Asthma Cough Variant variant Cough was conducted. asthma variant cough treat to pain for 14 of the 15 participants in the study. Jaw exercise exercise Jaw study. in the 14 of 15 participants for pain the Also noted, formula. the with was used in conjunction therapy the to prior months two for was practiced therapy exercise the fined as pain in the teeth. The effects The of teeth. the fined pain in as was taken formula The studied. were PDAP for as a treatment in to be improvement there show results The weeks. two for accompanying signs and symptoms; 3 cases were deemed inef deemed 3 cases were symptoms; signs and accompanying changes. no with fective Persistent dentoalveolar pain disorder cured, with blood glucose levels in normal range and accom and range in normal levels glucose blood with cured, 17 cases showed disappeared. symptoms signs and panying and levels of glucose blood both reduction with improvement Treatment course was 45 days. Efficacy of the treatment was treatment the Efficacy of was 45 days. course Treatment signs accompanying and levels glucose blood by determined deemed caseswere 32 showed results The symptoms. and modified differential TCM was also given. dietary advice and Exercise heat. stagnant stagnation with qi diagnosis was defined as liver ment. Additionally, no adverse events were noted. were events adverse no Additionally, ment. Diabetes Yao S an Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 10 ery. The total effectiveness ratewas 100%. some acuity improvement visual and partial field visual recov field returned to normal.eyes 23 showedimprovement with and edema subsided, improvement acuity, visual of and visual 102 eyes were deemed cured with the hyperemia optic of disk Wan treated optic (125eyes) neuritis 67cases using of to used been effectivelyhas treat optic neuritis. One study course liver qithan and Aurantium Immaturus Formula tion, improving circulation to the extremities. Bupleurum torso. Using for addressing cold extremities due to qistagnation the in qi stagnation, more is for excess conditions and most is noted Formula liver qistagnation. Bupleurum and Aurantium Immaturus San) significantly lowered compared beforeto the treatment. significantlyhigher beforethan treatment and TSH levels were mone levels. With the integrative approach, FT3and F4were alone, restoring and symptoms thyroid hor clinical improving approach proved to more be effective than Western medicine tion (TSH, FT3, and measured. FT4)was integrative The 21cases. of Treatment lasted three months. Thyroidfunc divided into atreatment and 25cases control group of group treatment Hashimoto’s of hypothyroidism. were 46cases tion with the Western pharmaceutical Levothyroxine for the investigate the integrative effects of Hashimoto’s Disease tion of Bupleurumtion of and Aurantium Immaturus Formula Bupleurum & Tang Kuei Formula thanuse adversely affected by stress. is It more suitable for long term patients with chronic spleen qiand blood deficiency who are & Tang Kuei Formula qi stagnation accompanied is with blood stasis. move blood, making it an effective choice for conditions where tions. This formula has the added actions invigorateto and qi stagnation and for can used be severe qistagnation situa Tang)Gan liver qistagnation. Hu Shu Gan Formula Bupleurum & Tang Kuei Formula Formula Comparisons tive effect on memory andimproving cognitiveimpairment. tive cells, reversing the induced condition, and having aposi animal hippocampus and increased expression PP-2A of posi showed that used. A- and inducedzheimer disease by intraperitoneal D-gal injection of of Alzheimer’s Disease— nerve causing pain and temporary loss. vision Neuritis—Optic Xiao Yao Wan . Both formulas harmonize the liver and spleen and treat with modifications dependent on patient presentations. Xiao Yao Wan β 1 ~42peptide bilateral hippocampal injection were Chai HuChai Shu Gan Formula (Si Ni San) focuses primarily focuses on the excess condition liver of chai hu chai hu Xiao Yao Wan Optic neuritis is inflammation of optic the of inflammation is neuritis Optic on Alzheimer’s Disease. Male rats with Al Chai HuChai Shu Gan Formula —A research study was conducted to to conducted was study research —A Bupleurum & Tang Kuei Formula was administered was for 28days. The results , the onefirst of formulasever created for and Research conducted was on the effect

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- - overacting on spleen, choosing between these two formulas can andsimilar signs symptoms. From this understanding liver of Plus Kuei Formula wood /earth disharmonies, much like Formula restricted to simply treating this pattern. formulatedwas to treat Classically, irritability,aches, nervousness, insomnia. and thein liver, manifesting spasms, as seizures, dizziness, head two formulas, to is address and wind liver ascent due to excess San)Gan liver blood, and regulate liver qi. wood overacting on earth. Both formulas support spleen qi, excess and deficiency at the same time.Both formulas address & Tang Kuei Formula Bupleurum Formula and liver blood. condition and treats also deficiency by nourishing spleen qi & Tang Kuei Formula Wan) Yao See next page for useful combinations. can achieved be with herbal formula combinations well. as for the specificperson and/or conditionbeing treated. This research currently being done additions uses to these formulas formulasbase for many disorders. Much the modern of Wanderer Formula Bupleurum & Tang Kuei Formula Combinations Wei Xiao Yao San) and kidney deficiency. yin are very different. but the underlying deficienciesbetween these two formulas Both formulas addressliveras as deficiency well qi stagnation, abdominal or epigastric pain, acid reflux, nausea or vomiting. tions caused by liver qistagnation, like hypochondriac pain, Formula treatment depression, is the of use swings,mood etc. Alternatively, the primary reason if for accompanied it is even if by other symptoms like depression, Bupleurum Formula driac the pain is primary reason for treatment, using Wei Xiao Yao San) Formula are moretoms pronounced, use Formula appears to more be physical nature, in use brokenbe follows. down as the If presentation symptoms of Linking Formula Free &Easy Wanderer Plus Wei Xiao Yao San)

Jia Wei Xiao( Yao San)

’s primary function, and main differencebetween the (Xiao Hu Chai Tang) (Xiao Yao Wan) (Xiao Yao Wan) (Xiao Hu Chai Tang) , but weaker is to nourish qiand blood. Minor Bupleurum FormulaMinor

(Xiao Yao Wan) Linking Formula (Yi Guan Jian) will be most be appropriate. will . An hypochon example this would if be of treats spleen qiand liver blood deficiency. Jia Wei Xiao( Yao San)

(Xiao Hu Chai Tang) (Yi Gan San)

(Xiao Yao Wan) (Xiao Yao Wan) shaoyang

or or or Free &Easy Wanderer Plus (Xiao Yao Wan) . These formulas address very Free &Easy Wanderer Plus Free &Easy Wanderer Plus Jia Wei Xiao( Yao San) has often has to used been treat . psycho-emotional If symp and and Bupleurum & Tang Kuei syndrome, but never been has Bupleurum Formula . Both treat similar condi Bupleurum & Tang Kuei is similar tois Free &Easy Wanderer (Yi Guan Jian) Bupleurum & Tang& Bupleurum . Both formulas treat addresses the excess

(Xiao Hu Chai Tang) Minor Bupleurum Bupleurum Minor Minor Bupleurum Bupleurum Minor

is most suitable, most is and and are very good Free &Easy Bupleurum Bupleurum treats liver Minor Minor

and (Yi

( Jia Jia (

-

- ( Jia Jia ( ( Jia Jia ( - -

Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 11

Journal of Liaoning of Liaoning Journal Gan Mai Da , 2014, Vol 33, No 17. No 33, Vol 2014, , or , 2011, Vol 32, No 1. No 32, Vol 2011, , , 2013, Vol 39, No 1. No 39, Vol 2013, , Psychiatry and Clinical , 2003. , Journal of Guangzhou University of Traditional of Traditional University of Guangzhou Journal Inner Mongolia in Medicine Inner Maturitas Phlegm-Transforming Formula Phlegm-Transforming Margarita Complexion Formula Complexion Margarita Immortals Formula Two Formula BloodPalace Mai Formula Sheng Formula and Atractylodes Peony Ease Digestion Formula Formula Fire Clear Viola Formula Capillaris Release Formula Chong Formula Ginseng and Longan Formula GB Lysmachia Formula Stasis-Transforming Bu Yang Huan Wu Tang Wu Huan Bu Yang Ban Xia Xie Xin Tang Jin Wan Zuo San Shen Ling Bai Zhu , it will be discovered that every substance listed as listed every substance that will it be discovered , Yunnan Chinese Magazine Medicine Yunnan Persica and Cistanches Formula and Cistanches Persica Combine with Combine Combine with with Combine with Combine with Combine Tang Zao with Combine with Combine with Combine with Combine with Combine with Combine with Combine with Combine with Combine with Combine or with Combine with Combine with Combine Journal of Obstetrics Journal and Gynaecology Research ombinations 2009, Vol 33, No 8. No 33, Vol 2009, materia medica , 2009, Vol 33, No 9. No 33, Vol 2009, , C , 2007, Vol 33, No 3. No 33, Vol 2007, , , 2011, Vol 45, No 11. No 45, Vol 2011, , l sefu U , 2012. , , 2005. , , 2014, Vol 22, No 1. No 22, Vol 2014, , , 2009. , , 2014. , Journal of PsychiatricJournal Research , 2011, Vol 137, No 3. No 137, Vol 2011, , The Journal of Obstetrics and GynaecologyResearch and of Obstetrics Journal The , 2006. ,

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Progress in Neuro-Psychopharmacology and Biological Psychiatry , 2007. , The Chinese Journal of Clinical Pharmacology of Clinical Journal The Chinese ComplementaryMedicine Therapiesin For jaundice or hepatitis jaundice For Inflammatory Disease Pelvic For Ovary (PCOS) Polycystic Syndrome For For hepatitis For hyperlipidemia For IBS constipation For IBS diarrhea For For painful diarrhea For functional dyspepsia For cholecystitis epigastric pain or chronic For ulcer H-pylori For Herpes Zoster For For breast hyperplasia breast For neurosis cardaic For hyperthyroidism or syndrome fatigue chronic For after stroke depression For For acne For Hidaka T, et al., “Kami-shoyo-san, Kampo (Japanese Traditional Medicine), is Effective for Climacteric Syndrome, Especially in Hormone-replacement- in Especially Syndrome, for Climacteric is Effective Medicine), (Japanese Kampo “Kami-shoyo-san, Traditional et al., T, Hidaka Feng Qi, et al., “Use of Xiao Yao San Treatment for Primary Dysmenorrhea in 58 Cases,” in 58 Cases,” Dysmenorrhea Primary for Treatment San Yao of “Use Xiao et al., Qi, Feng Hua Ning Wang, et al., “Free & Easy Wanderer Plus (FEWP), A Polyherbal Preparation, Ameliorates PTSD-like Behavior and Cognitive Impairments in Impairments Cognitive and Behavior PTSD-like Ameliorates Preparation, Polyherbal A (FEWP), Plus Wanderer & Easy“Free et al., Wang, Ning Hua Chen LC, et al., “A Pilot Study Comparing the Clinical Effects of Jia-Wey Shiau-Yau San, a Traditional Chinese Herbal Prescription, and a Continuous Continuous a and Prescription, Herbal Chinese Traditional a San, Shiau-Yau Jia-Wey of Clinical Effects the Comparing Study Pilot “A et al., Chen LC, Wei Ming Xiu, “Clinical Analysis of 50 Cases of Irregular Menstruation Treated with Xiao Yao San,” San,” Yao Xiao with Treated of 50 Cases Menstruation Analysis of Irregular “Clinical Xiu, Ming Wei Hsing-Yu Chen, et al., “Investigation on Chinese Herbal Medicine for Primary Dysmenorrhea: Implication from a Nationwide Prescription Database in Database Prescription a Nationwide from Implication Dysmenorrhea: Primary for Medicine Chinese on Herbal “Investigation et al., Chen, Hsing-Yu Hua-Ning Wang, et al., “Free & Easy Wanderer Plus (FEWP), a Polyherbal Preparation, Ameliorates PTSD-like Behavior and Cognitive Impairments in Impairments Cognitive and Behavior PTSD-like Ameliorates Preparation, a Polyherbal (FEWP), Plus Wanderer & Easy“Free et al., Wang, Hua-Ning Hsing-Yu Chen, et al., “Prescription patterns of Chinese herbal products for menopausal syndrome: Analysis of a Nationwide Prescription Database,” Database,” Prescription of a Nationwide Analysis syndrome: menopausal for of products Chinese patterns herbal “Prescription et al., Chen, Hsing-Yu Kazuo Yamada, et al., “Effectiveness of Kamishoyosan for Premenstrual Dysphoric Disorder: Open-labeled Pilot Study,” Study,” Pilot Open-labeled Disorder: Dysphoric Premenstrual for of“Effectiveness Kamishoyosan et al., Yamada, Kazuo Hsing-Yu Chen, et al., “Identifying Chinese Herbal Medicine for Premenstrual Syndrome: Implications from a Nationwide Database,” BMC Database,” a Nationwide from Implications Syndrome: Premenstrual for Medicine Chinese“Identifying Herbal et al., Chen, Hsing-Yu Li Qiang, et al., “Randomized Double-blind Controlled Clinical Trial of the Combination of Xiao-Yao-San and Carbamazepine in the Treatment of Bipolar Treatment in the Carbamazepine and of Xiao-Yao-San of Combination the Trial Clinical “Randomized Controlled Double-blind et al., Li Qiang, Xu ZhiWei, et al., “Experimental Study on Antianxietic Action of Xiao Yao San and Dan Zhi Xiao Yao San,” Yao Zhi Xiao Dan and San Yao of Xiao Action Antianxietic “Experimental on Study et al., ZhiWei, Xu YuQing Zhang, et al., “Chinese Herbal Formula Xiao Yao San for Treatment of Depression: A Systemic Review of Randomized Controlled Trials,” Trials,” Review of Randomized Systemic A Controlled of Depression: Treatment for San Yao Xiao Formula Herbal “Chinese et al., Zhang, YuQing Feng Qin, et al., “Meta-analysis of Randomized Controlled Trials to Assess the Effectiveness and Safety of Free & Easy Wanderer Plus, a Polyherbal Polyherbal a Plus, Wanderer & Easy Free of Safety and Effectiveness the Assess to Trials “Meta-analysis of Randomized Controlled et al., Qin, Feng Kimura Y, et al., “Kampo Therapy for Premenstrual Syndrome: Efficacy of Kamishoyosan Quantified Using the Second Derivative of the Fingertip Fingertip the of Derivative Second the Using Quantified Efficacy of Kamishoyosan Syndrome: Premenstrual “Kampo for Therapy et al., Y, Kimura Xue Hong, et al., “Dan Zhi Xiao Yao San with Mirtazapine Treatment of Generalized Anxiety Control Study of Sleep Disorders,” of Disorders,” Sleep Study Control Anxiety of Generalized Treatment Mirtazapine with San Yao “Dan Zhi Xiao et al., Hong, Xue We often separate liver yin and liver blood in TCM. But if one examines the if the But examines one TCM. in blood liver yin and liver separate often We Combined Hormone Replacement Therapy in Postmenopausal Women with Climacteric Symptoms,” Symptoms,” Climacteric with Women Postmenopausal in Therapy Replacement Hormone Combined xvii Symptoms,” of Psychological Complain Strongly who Patients therapy-resistant xv of EthnopharmacologyJournal xvi Taiwan,” Taiwan,” xiii xiv Photoplethysmogram,” xi Neurosciences xii Stressed Rats,” Rats,” Stressed ix Complementary and Alternative Medicine x vii Rats,” Stressed viii v Chinese Medicine ofUniversity Traditional vi Disorders,” Evidence-Based Complementary and Alternative Medicine iv Chinese Medicine supplements direct the yin nourishment to the heart. The second category can be seen in these categorizations as equating liver blood and liver yin. liver bloodand liver equating as categorizations these can be seen in category The second heart. the to yin nourishment the direct supplements ii Disorders,” Depressive for Preparation iii supplementing/ tonifying/ nourishing liver yin never has only that action. All of the liver-yin nourishing herbs fall into one of three categories: 1) nourish 1) nourish categories: of one three fall into herbs nourishing ofAll liver-yin the action. that has yin never only liver nourishing tonifying/ supplementing/ usually ofup substances, made is heavy category third The yang. anchor yin and liver 3) nourish or blood, yin and liver 2) nourish yin, liver and kidney kidney yin really are category The first body. the yin to adding therefore are and yang the upon action anchoring an have density very their by that minerals, yin kidney Other of some benefit. the receives liver the that a way yin in such kidney the nourish they say, is to that liver, the also nourish that supplements Endnotes Endnotes i Bupelurum & Tang Kuei Formula / Free & Easy Wanderer Plus 12 xxix Medicine In Traditional Medicine, Chinese lxi 8, No 12. lx lix lviii lvii Medica lvi lv liv liii University Traditional of Medicine Chinese lii li l Dentoalveolar Pain Disorder,” xlix Nutrition xlviii Neurosciences Clinical xlvii San,” xlvi Research xlv Study,” xliv No 8. xliii 11, No 41. xlii Traditional Medicine China in Chinese xli Medicine xl 21, No 9. xxxix xxxviii Clinics ofChinese Materia Medica xxxvii Scientific World Journal xxxvi xxxv xxxiv xxxiii No 2. xxxii xxxi xxx Cancer Patients: A Population BasedStudy,” xxviii xxvii Medicine Alternative and Complementary xxvi Medicine xxv Traditional Medicine xxiv xxiii xxii xxi xx Type,” xix Traditional Medicine, Chinese xviii Zhang Yan Feng, al., et “Clinical Study Xiao of Yao San for Cough Variant Asthma,” Guo Ying, al., et Herpes of Zoster“152 Cases treated with DZXS,” Zhang Shi, al., et “Tao Hong Si Wu Tang combined with Xiao Yao San Treating Hyperlipidemia,” Da Lian, al., et Xiao“Clinical Observation of Yao San with Euthyrox Treatment Hashimoto’s of Hypo thyroidism,” Pang Ying Hua, al., et “Therapeuticof ShengEffect Mai San plus Xiao Yao inSan the Chronic Treatmentof Fatigue Syndrome,” Zhang Zhang, Chloasma, of Liver QiCasesStagnation,” of 60 “Clinical Efficacy Wang Jun, al., et of ZhiDan Xiao “Efficacy of Recurrent CasesYao San on40 Oral Ulcers,” Lu ling Ying, “Modified Xiao Yao San for Treatment Diarrhea-Predominant of IrritableBowel Syndrome,Cases,” 36 S Zhang Hua, of Xiao “Efficacy of theYao San Chronic of Pharyngitis,”Cases Treatmentof 92 Zhao, Wei Xian, al., et Xiao of “Effects Yao Powder on Hippocampal CA1 Area Related Indexes Alzheimers’sof Rats,”in Disease Lv Jie, al., et “Application Xiao of Yao San Treating Optic Neuritis,” Xiang Ai Min, Mo“Si Tang Combined with Xiao Yao San to Treat Constipation-Predominant Irritable Bowel Syndrome,” Chen Liang,Chen Xiao Zhi “Dan Yao San treatment Fibromyalgia of Syndrome, 27cases,” Wang Qiu Xia, al., et Liver Depression of “25 Cases and Infertility Treated with Modified Xiao Yao San,” Yuan Ying Jun, al., et “Therapeutic of efficacy Modified Zhi Dan Xiao Yao Powder on PolycycsticOvary Syndrome with Liver Depression andBlood Heat Wang Yu, “Modified Xiao Yao San Treats of Cases 86 Acne,” Liu XiTing, al., et Breast Hyerplasia of 48Cases “Clinical Observation of Treatment with Jia Wei Xiao Yao San,” Ji Jiang Hong, al., et “Clinical Observation on Treating Chronic Cholecystitis of with Ban 78Cases Xia Xie Xin Decoction plus Xiao Yao San,” Guo Guo, al., et “Xiao Yao San Treat Impotence,” of 123Cases Du ChunXia,Du Menstrual“Treating of Headache 96Cases with Xiao Yao San,” Zhang Hong Wei, al., et Chronic Gastritis“Clinical Observation of Treated by Jia Wei Xiao Yao San,” Mu XueLian, Migraines of 49Cases Treated“Clinical Observation of with Xiao Yao San,” Zhang GL, “Treatment Breast Proliferation of with Modified Disease Xiao Yao San andChen Er Decoction,” Jung-Nien Lai, al., et “Prescription Pattern Herbal Chinese of Products for Breast Cancer in Taiwan: A Population-Based Study,” Li Peng,Li al., et “Xiao Yao San Enteric-Coated Tablets Combined with Mesalazine for the Treatment Ulcerative of Colitis Controlled aRandomized in Wang Liang Xin, Insomnia with“Summarization the of Liver on Stagnation 40Cases Qi of Transforming into Liver Fire Treated with Dan Xiao Zhi Yao Feng Hua, “Xiao Yao San Treating Retrograde of Ejaculation,” 98Cases Zhen,Liu fu al., et “Jia Wei Xiao Yao Hyperprolactinemia,” San treatment of 30Cases of Young-Chang P, al., et Kamishoyosan, of “Effects a Traditional JapaneseKampo Medicine, on Pain Conditionsin Patientswith Intractable Persistent Wang Qiao, al., et Xiao Zhi “Dan Yao San Application Results the in Treatment Chronic Pelvic of InflammatoryObserved,” was Disease Zhang Qing, Li al., et “Modified Xiao Ovarian Yao San Cysts,”treatment of Cases 36 of Quan Shun, al., et Jin“Zou Wan with Dan Xiao Zhi Yao San Treatment Liver Stomach of Heat Stomach Ulcer,” Yueh-Hsiang Liao, al., et “Adjunctive Traditional Medicine Chinese Therapy ImprovesLiver Cancer Survival of Patients,” Du Du Yanlin, al., et of CancerBreast after ChemotherapyCombination“Efficacy of with Jia Wei Xiao Yao San,” Toshihiro Ishikawa, al., et (TJ-24) KampoKami-Shoyo-Santhe for “Effectiveness of Tremor of Antipsychotic-induced Parkinsonism,” Yong Sheng, al., et “Jia Wei Xiao Yao San Treating Chronic Prostatitis,” of 60Cases Hu Yan, al., et Chronic Hepatitis of 32Cases B “Clinical Observation of Treated with Dan Xiao Zhi Yao San,” Shu-Chen Chien, al., et “A Herbal Chinese Medicine, Jia-Wei-Xiao-Yao-San, Prevents Dimethylnitrosamine-Induced Hepatic Fibrosis Rats,” in Zheng Fu Jie, al., et “Evaluate Jia Wei Xiao Yao San for Irritable Bowel Syndrome,” Yueh Ting Tsai, al., et “The Chinese Herbal Use of Products and its Influence on Tamoxifen Induced Endometrial CancerRisk among Female Breast Liu Hai, al., et “Metformin Combination of Traditional Medicine Chinese TreatmentofCases of 52 Efficacy IIType Diabetes,” He Ye, al., et “Xiao Yao San Treat Fatty of 86Cases Liver,” Chen Xi,Chen al., et “Protective Effects of Administered Xiao Yao Powderin the Morning and Chronic Liver Evening Rats,”of Injuryin Yang Qu, al., et “Study on the effect of Jia Wei Xiao Yao San decoction on patientswith functional dyspepsia,” Hunan Guiding TCM Journal of Hebei Traditional Medicine Chinese , 2007, Vol 2, No 24. Practical TraditionalPractical InternalMedicine Chinese , 2014, Vol 6, No 29. , 2009, No 4. , 2013, No 3. , 2013, No 7. , 1991, Vol 11, No 7. , 2000. , 2014. 2011, No 8. Evidence-Based Complementary and Alternative Medicine Alternative and Complementary Evidence-Based , 2010, Vol 6, No 3. , 2004, Vol 10, No 1. , 2007, Vol 14, No 4. , 2012. 2014, Vol 20, No 7. , 2013, No 3. , 2014, Vol 36, No 8. Journal Ethnopharmacology of , 2014, No 3. Global Chinese Medicine Chinese Global Journal of Liaoning College of Traditional of Journal College Liaoning Medicine of Chinese Chinese Medicine Oration Chinese Jilin Medical Journal Contemporary Chinese Medicine Chinese Contemporary , 2014, Vol 155, No 2. Chinese Medical Professional Chinese Clinical Journal ofTCM Journal ofDermatology Changchun University of Traditional Universityof Medicine Chinese Changchun , 2012, Vol 5, No 9. , 2014. China Journal of Experimental Traditional Journal Medical Experimental of FormulaeChina Journal of Practical TraditionalJournal Practical of InternalMedicine, Chinese Jiangsu Traditional Medicine Chinese , 2011, No 24. , 2011, No 10. Shaanxi TraditionalShaanxi Medicine Chinese Guangming Chinese Medicine Chinese Guangming Clinical and Experimental Medicine Experimental and Clinical Special HealthSpecial Yunnan Journal Traditional of Medicine Materia and Chinese Chinese Journal of Basic Medicine Journal Basic of Chinese , 2010, Vol 10, No 28. , 2008, Vol 10, No 12. , 2014 Vol 9. World HealthMedical Periodical Digest , 2011, Vol 3, No 17. , 2014, No 2. Chinese NaturopathyChinese Modern Medicine Modern Chinese Journal ofModern in Developments Phytotherapy ResearchPhytotherapy China Academic Journal, China Gansu Journal ofTraditional Chinese China Modern Medicine Modern China Medical Innovation China of handong Traditionalhandong Chinese , 2005, Vol 7, No 2. , 2008, Vol 23, No 11. , 2007, No 2. Liver International, International, Liver Journal ofInformation on , 2006, Vol 5, No 4. , 2013, Vol 21, No 1. , 2008, Vol 29, No 7 , 2015, Vol 24, No 3. Journal ofGuangzhou China Healthcare and Chinese Journal of Basic Evidence-Based Evidence-Based , 2012, Vol 18, No 8. Pharmacology and and Pharmacology , 2010, Vol 24, No 2. , 2008. Psychiatry and and Psychiatry 2009. , 2010 Vol 10, Inner Mongolia ,2011, Vol 2003, Vol 17, ,2011, Vol 2015. Clinical Clinical ,2015, Vol The