Abridged Curriculum Vitae JM Warwick

Personal Information:

Name: James Mathew Warwick Born: , 9 March 1968 Family: Married, 2 children Nationality: South African Languages: English (home language) (fluent)

Contact Information: Address: Nuclear Medicine Hospital Cape Town 7505 Telephone: +27 +21 938 4265 Fax: +27 +21 938 4694 Email: [email protected]

Academic Qualifications and Registrations

1985 Matriculated, Westerford High School, Cape Town

1986 – 1988 BSc, (major subjects: physics, applied mathematics)

1989 – 1993 MBChB, University of Cape Town

January 1995 Registered as a Medical Practitioner

October 1999 FCNP, Colleges of Medicine of South Africa

1996 - 2000 MMed (Nuclear Medicine), Stellenbosch University

June 2000 Registered as a Specialist Nuclear Medicine Physician

2004 – 2009 PhD (Nuclear Medicine), Stellenbosch University

Positions Held:

Jan 1994 – Dec 1994 Intern and Somerset Hospitals, Cape Town

Feb 1995– Nov 1995 Senior House Officer in Orthopaedic Surgery, and Accident and Emergency Medicine, United Kingdom

Jan 1996 – Jun 2000 Registrar in Nuclear Medicine, Stellenbosch University and , Cape Town

July 2000 - Apr 2005 Specialist and Lecturer in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town

May 2005 to April 2010 Senior Specialist and Lecturer in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town

April 2010 - date Associate Professor in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town

1 Publications

Total citations=1289, h-index=19, i10-index 30 (Google Scholar October 2018)

Book Chapters 1. Warwick JM, Stein DJ, Carey P. Social Anxiety Disorder in: Nuclear Medicine in Psychiatry Eds Otte, Dierckx, Audenaert. Springer 2004 2. Carey PD, Stein DJ, Seedat S, Warwick J. Posttraumatic Stress Disorder in: Nuclear Medicine in Psychiatry Eds Otte, Dierckx, Audenaert. Springer 2004 3. Nelissen N, Warwick J, Dupont P. Kinetic Modelling in Human Brain Imaging in: Positron Emission Tomography Ed Hsieh. Intech 2012 4. Doruyter AGG, Stein DJ, Warwick JM. Neurobiology of Posttraumatic Stress Disorder: The role of nuclear neuroimaging. In: PET and SPECT in Psychiatry Eds Dierckx, Otte, Vries, Waarde, Boer. Springer 2014 5. Joska JA, Warwick JM. Investigating Psychiatric Disorders. In: Textbook of Psychiatry for Southern Africa (2nd Edition) Eds Burns, Roos. Oxford University Press Southern Africa 2016 Theses/Dissertations 6. Warwick J. An Investigation of the Potential Role of Artificial Neural Networks in Predicting the Response of Patients to I-131 Treatment for Hyperthyroidism – a Retrospective Study. Submitted for degree of Master of Medicine (Nuclear Medicine), Stellenbosch University 2000 7. Warwick JM. An Investigation of the Pathophysiology of Social Anxiety Disorder using Brain SPECT. Submitted for degree of Doctor of Philosophy (Nuclear Medicine), Stellenbosch University 2009. Papers 8. Stein DJ, Van Heerden B, Wessels CJ, Van Kradenburg J, Warwick J, Wasserman HJ. Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry 1999;23:1079-1099 9. Van der Linden G, Van Heerden B, Warwick J, Wessels C, Van Kradenburg J, Zungu- Dirwayi N, Stein D. Functional brain imaging and pharmacotherapy in social phobia: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2000;24:419-438 10. Van Laere KJ, Warwick J, Versijpt J, Goethals I, Audenaert K, Van Heerden B, Dierckx R. Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: an ROC-based comparison of visual, semiquantitative, and voxel-based methods. Journal of Nuclear Medicine 2002;43:458-469 11. Vythilingum B, Warwick J, Van Kradenburg J, Wessels C, Van Heerden B, Stein D. SPECT scans in identical twins with Trichotillomania. Journal of Neuropsychiatry and Clinical Neuroscience 2002;14:340-342 12. Stein DJ, Van Heerden BB, Hugo C, Van Kradenburg J, Warwick J, Zungu-Dirwayi N, Seedat S. Functional brain imaging and pharmacotherapy in trichotillomania: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2002;26:885-890 13. Sathekge M, Warwick J. Letter to the Editor: “Nuclear Medicine in South Africa”. South African Medical Journal 2003;93:88-90 14. Seedat S, Warwick J, Van Heerden BB, Hugo C, Zungu-Dirwayi N, Van Kradenburg J, Stein DJ. Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with the selective serotonin reuptake inhibitor citalopram. Journal of Affective Disorders 2004;80:45-53 15. Warwick JM. Imaging of brain function using SPECT. Metabolic Brain Disease, 2004;19:113- 123 16. Carey PD, Warwick J, Harvey BH, Stein DJ, Seedat S. Single photon emission computed tomography of obsessive-compulsive disorder before and after treatment with Inositol. Metabolic Brain Disease 2004;19:125-134

2 17. Carey P, Seedat S, Warwick J, Van Heerden B, Stein D SPECT Imaging of body dysmorphic disorder. Journal of Neuropsychiatry and Clinical Neuroscience 2004;16:357-359 18. Carey PD, Warwick J, Niehaus DJH, Van der Linden G, Van Heerden BB, Harvey BH, Seedat S, Stein DJ. Single photon computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram. BMC Psychiatry 2004;4:30 19. Möller J, Warwick J, Bouma H. Miokardiale Perfusiebeelding met Tc-99m MIBI in pasiënte met linker Bondeltakblok : Die visuële en kwantitiewe beoordeling van anteroseptale perfusie vir die diagnose van linker afdalende arterie stenose. Cardiovascular Journal of South Africa 2005;16:95-101 20. Van Toorn R, Rabie H, Warwick J. Opsoclonus myoclonus-associated immune reconstitution syndrome in a HIV infected child. European Journal of Paediatric Neurology 2005;9:423-6 21. Sathekge MM, Warwick J, Vangu MDT, Ellmann A, Mann M. A Case for the Provision of Positron Emission Tomography (PET) in South African Public Hospitals South African Medical Journal 2006;96:598-601 22. Stein DJ, Carey PD, Warwick J. Beauty or Beast: Psychobiologic and Evolutionary Perspectives on Body Dysmorphic Disorder CNS Spectr 2006;11:419-422 23. Warwick JM, Carey P, Van der Linden G, Prinsloo C, Niehaus D, Seedat S, Dupont P, Stein DJ. A Comparison of the effects of citalopram and moclobemide on resting brain perfusion in Social Anxiety Disorder. Metabolic Brain Disease 2006;21:241-252. 24. Stein DJ, Daniels W, Emsley R, Harvey B, Blackburn J, Carey P, Ellis G, Illing N, Flisher A, Moolman-Smook H, Mwaba K, Ramesar R, Russell V, Seedat S, Tredoux C, Vaughan CL, Vythilingum B, Warwick J. A brain-behaviour initiative for South Africa: the time is right. Metabolic Brain Disease 2006;21:279-284. 25. Warwick JM, Ellmann A, Hough FS. Positron emission tomography (PET) in endocrine tumours. JEMDSA 2007;12:18-23 26. Elmadani AE, Warwick JM, Ellmann A. The contribution of bone SPECT to the diagnosis of bone metastases in an African population. Nuclear Medicine Communications 2008;29:254- 259. 27. Warwick JM, Carey P, Jordaan GP, Dupont P, Stein D. Resting Brain Perfusion in Social Anxiety Disorder: a Voxel-wise whole brain comparison with healthy control subjects. Progress in Neuropsychopharmacology & Biological Psychiatry 2008;32:1251-1256. 28. Dupont PD, Warwick JM. Kinetic modelling in small animal imaging with PET. Methods 2009;48:98-103. 29. Jordaan GP, Warwick JM, Hewlett R, Emsley R. Resting brain perfusion in alcohol-induced psychotic disorder: a comparison in patients with alcohol dependence, schizophrenia and healthy controls. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010;34:479-485. 30. Ndlovu X, George R, Ellmann A, Warwick JM. Should SPECT-CT replace SPECT for the evaluation of equivocal bone scan lesions in patients with underlying malignancies ? Nuclear Medicine Communications 2010;31:659-665. 31. Cassimjee N, Burnett M, Lochner C, Warwick J, Dupont P, Stein DJ, Cloete K, Carey PD. Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram. Metabolic Brain Disease 2010;25:369-374. 32. Warwick JM, Sathekge MM. PET/CT scanning with a high HIV/AIDS prevalence. Transf Apheres Sci 2011;44:167–172. 33. Warwick JM, Rubow S, Du Toit M, Beetge E, Carey P, Dupont P. The role of CT based attenuation correction and collimator blurring correction in striatal SPECT quantification. International Journal of Molecular Imaging. 2011;2011:Article ID 195037, 9 pages 34. Ding J, Chen H, Liao W, Warwick JM, Duan X, Qiu C, Zhang W, Gong Q. Disrupted Functional Connectivity in Social Anxiety Disorder: A Resting State fMRI Study. Magn Reson Imaging 2011;29:701-711. 35. Jordaan GP, Warwick JM, Nel DG, Hewlett R, Emsley R. Alcohol-induced Psychotic Disorder: Brain Perfusion and Psychopathology – before and after Anti-Psychotic Treatment. Metabolic Brain Disease 2012;27:67-77. 36. Warwick JM, Carey PD, Cassimjee N, Lochner C, Hemmings S, Moolman-Smook H, Beetge E, Dupont P, Stein DJ. Dopamine Transporter Binding in Social Anxiety Disorder: the effect of Treatment with Escitalopram. Metabolic Brain Disease 2012;27:151-158.

3 37. Warwick J. Nuclear Medicine in South Africa (Editorial). Continuing Medical Education 2013;31:278. 38. Warwick J, Lotz J. Integrated imaging - the complementary roles of Radiology and Nuclear Medicine. Continuing Medical Education 2013;31:298-303. 39. Warwick J. Brain imaging with SPECT and PET. Continuing Medical Education 2013;31:307- 309. 40. Holness JL, Fleming JS, Malaroda AL, Warwick JM. 99mTc-DTPA volume of distribution, half-life and GFR in normal adults. Nuclear Medicine Communications 2013;34:1005-1014. 41. Warwick J, Lotz J. Integrated imaging - the complementary roles of Radiology and Nuclear Medicine. SAJR 2013;17:149-153. (reprint) 42. Doruyter AG, Hartley T, Ameyo JW, Davids MR, Warwick JM. Hybrid imaging using low- dose, localizing CT enhances lesion localisation in renal hyperparathyroidism. Nuclear Medicine Communications 2014;35:884-889. 43. Shaw JA, Irusen EM, Von Groote-Bidlingmaier F, Warwick J, Jeremic B, Koegelenberg CFN. Integrated PET-CT for evaluation of mediastinal lymph node staging of non-small-cell lung cancer in a tuberculosis-endemic area: a five year prospective observational study. South African Medical Journal 2015;105:145-150. 44. Holness JL, Fleming JS, Warwick JM. Measuring GFR using the plasma clearance of Tc- 99m DTPA Am J Kidney Dis 2015;65:806. 45. Sathekge M, Warwick JM, Doruyter A, Vorster M. Appropriate indications for positron emission tomography/computed tomography: College of Nuclear Physicians of the Colleges of Medicine of South Africa. South African Medical Journal 2015;105:894-896. 46. Du Toit R, Irusen EM, Shaw JA, Von Groote-Bidlingmaier F, Warwick JM, Koegelenberg CFN. The diagnostic accuracy of integrated positron emission tomography/computed tomography in the evaluation of pulmonary mass lesions in a tuberculosis-endemic area. South African Medical Journal 2015;105:1049-1052. 47. M Vorster, A Doruyter, A Brink, S Mkhize, J Holness, N Malan, N Nyakale, J M Warwick, M Sathekge, on behalf of the College of Nuclear Physicians of South Africa. Appropriate indications for positron emission tomography/computed tomography, 2015. South African Medical Journal 2016;106:105-123. 48. Doruyter A, Lochner C, Jordaan G, Stein D, Dupont P, Warwick J. Resting functional connectivity in social anxiety disorder and the effect of pharmacotherapy. Psychiatry Research: Neuroimaging 2016;251:34-44. 49. Esmail H, Lai RP, Lesosky M, Wilkinson KA, Graham CM, Coussens AK, Oni T, Warwick JM, Said-Hartley Q, Koegelenberg CF, Walzl G, Flynn JL, Young DB, Barry CE 3rd, O’Garra A, Wilkinson RJ. [18F]-fluoro-deoxyglucose combined positron emission and computed tomographic characterisation of progressive HIV-associated tuberculosis. Nature Medicine (in press) 50. Malherbe ST, Ronacher K, Shenai S, Kriel M, Dolganov G, Alland D, Barry C III, Chen R, Via L, Warwick JM, Schoolnik G, Tromp G, Winter J, Walzl G, Catalysis TB-Biomarker Consortium. PET/CT imaging and Mycobacterium tuberculosis mRNA transcript analysis suggest pathogen persistence after curative treatment of pulmonary tuberculosis. Nature Medicine 2016;22:1094-1100. 51. Malherbe ST, Shenai S, Ronacher K, Loxton AG, Dolganov G, Kriel M, Van T, Chen RY, Warwick J, Via LE, Song T, Lee M, Schoolnik G, Tromp G, Alland D, Barry CE 3rd, Winter J, Walzl G; Catalysis TB–Biomarker Consortium. Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure. Nature Medicine 2017;23:526. 52. Thompson EG,Ying D, Malherbe ST, Smith S, Braun J, Valvo J, Ronacher K, Tromp G, Tabb DL, Alland D, Shenai S, Via LE, Warwick J, Aderem A, Scriba TJ, Winter J, Walzl G, Zak DE; Catalysis TB–Biomarker Consortium. Host blood RNA signatures predict the outcome of tuberculosis treatment. Tuberculosis 2017;107:48-58. 53. Doruyter A, Groenewold NA, Dupont P, Stein DJ, Warwick JM. Resting‐state fMRI and social cognition: An opportunity to connect. Hum Psychopharmacol. 2017 Sep;32(5). doi: 10.1002/hup.2627 54. Doruyter A, Dupont P, Taljaard L, Stein DJ, Lochner C, Warwick JM. Resting regional brain metabolism in social anxiety disorder and the effect of moclobemide therapy. Metab Brain Dis. 2017 Nov 3. doi: 10.1007/s11011-017-0145-7

4 55. Morkel M, Ellmann A, Warwick J, Simonds H. Evaluating the role of F-18 FDG PET/CT scanning in the staging of stage IIIB cervical carcinoma patients and the impact on treatment decisions. International Journal of Gynecological Cancer 2018;28:379-384. doi:10.1097/IGC.0000000000001174 56. Malherbe ST, Dupont P, Kant I, Ahlers P, Kriel M, Loxton AG, Chen RY, Via LE, Thienemann F, Wilkinson RJ, Barry CE III, Griffith-Richards S, Ellmann A, Ronacher K, Winter J, Walzl G, Warwick JM and the Catalysis Biomarker Consortium. A semi- automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images. EJNMMI Research 2018;8:55. doi:10.1186/s13550-018-0411-7 57. Lawal I, Louw L, Warwick J, Nyakale N, Steyn R, Lengana T, Ellmann A, Kotze T, Vangu M, Vorster M, Sathekge M. The College of Nuclear Physicians of South Africa Practice Guidelines on Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumours. S Afr J Surg 2018;56:55-64. doi:10.17159/2078-5151/2018/v56n3a2775 58. Doruyter AG, Dupont P, Stein DJ, Lochner C, Warwick JM. Nuclear neuroimaging in social anxiety disorder: a review. Journal of Nuclear Medicine 2018 (in press) 59. Vuletic D, Dupont P, Robertson F, Warwick J, Zeevaart JR, Stein DJ. Methamphetamine dependence with and without psychotic symptoms: a multi-modal brain imaging study. Neuroimage 2018 (in press)

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