Abridged Curriculum Vitae JM Warwick Personal Information: Name: James Mathew Warwick Born: Cape Town, 9 March 1968 Family: Married, 2 children Nationality: South African Languages: English (home language) Afrikaans (fluent) Contact Information: Address: Nuclear Medicine Tygerberg Hospital Cape Town South Africa 7505 Telephone: +27 +21 938 4265 Fax: +27 +21 938 4694 Email: [email protected] Academic Qualifications and Registrations 1985 Matriculated, Westerford High School, Cape Town 1986 – 1988 BSc, University of Cape Town (major subjects: physics, applied mathematics) 1989 – 1993 MBChB, University of Cape Town January 1995 Registered as a Medical Practitioner October 1999 FCNP, Colleges of Medicine of South Africa 1996 - 2000 MMed (Nuclear Medicine), Stellenbosch University June 2000 Registered as a Specialist Nuclear Medicine Physician 2004 – 2009 PhD (Nuclear Medicine), Stellenbosch University Positions Held: Jan 1994 – Dec 1994 Intern Groote Schuur and Somerset Hospitals, Cape Town Feb 1995– Nov 1995 Senior House Officer in Orthopaedic Surgery, and Accident and Emergency Medicine, United Kingdom Jan 1996 – Jun 2000 Registrar in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town July 2000 - Apr 2005 Specialist and Lecturer in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town May 2005 to April 2010 Senior Specialist and Lecturer in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town April 2010 - date Associate Professor in Nuclear Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town 1 Publications Total citations=1289, h-index=19, i10-index 30 (Google Scholar October 2018) Book Chapters 1. Warwick JM, Stein DJ, Carey P. Social Anxiety Disorder in: Nuclear Medicine in Psychiatry Eds Otte, Dierckx, Audenaert. Springer 2004 2. Carey PD, Stein DJ, Seedat S, Warwick J. Posttraumatic Stress Disorder in: Nuclear Medicine in Psychiatry Eds Otte, Dierckx, Audenaert. Springer 2004 3. Nelissen N, Warwick J, Dupont P. Kinetic Modelling in Human Brain Imaging in: Positron Emission Tomography Ed Hsieh. Intech 2012 4. Doruyter AGG, Stein DJ, Warwick JM. Neurobiology of Posttraumatic Stress Disorder: The role of nuclear neuroimaging. In: PET and SPECT in Psychiatry Eds Dierckx, Otte, Vries, Waarde, Boer. Springer 2014 5. Joska JA, Warwick JM. Investigating Psychiatric Disorders. In: Textbook of Psychiatry for Southern Africa (2nd Edition) Eds Burns, Roos. Oxford University Press Southern Africa 2016 Theses/Dissertations 6. Warwick J. An Investigation of the Potential Role of Artificial Neural Networks in Predicting the Response of Patients to I-131 Treatment for Hyperthyroidism – a Retrospective Study. Submitted for degree of Master of Medicine (Nuclear Medicine), Stellenbosch University 2000 7. Warwick JM. An Investigation of the Pathophysiology of Social Anxiety Disorder using Brain SPECT. Submitted for degree of Doctor of Philosophy (Nuclear Medicine), Stellenbosch University 2009. Papers 8. Stein DJ, Van Heerden B, Wessels CJ, Van Kradenburg J, Warwick J, Wasserman HJ. Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry 1999;23:1079-1099 9. Van der Linden G, Van Heerden B, Warwick J, Wessels C, Van Kradenburg J, Zungu- Dirwayi N, Stein D. Functional brain imaging and pharmacotherapy in social phobia: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2000;24:419-438 10. Van Laere KJ, Warwick J, Versijpt J, Goethals I, Audenaert K, Van Heerden B, Dierckx R. Analysis of clinical brain SPECT data based on anatomic standardization and reference to normal data: an ROC-based comparison of visual, semiquantitative, and voxel-based methods. Journal of Nuclear Medicine 2002;43:458-469 11. Vythilingum B, Warwick J, Van Kradenburg J, Wessels C, Van Heerden B, Stein D. SPECT scans in identical twins with Trichotillomania. Journal of Neuropsychiatry and Clinical Neuroscience 2002;14:340-342 12. Stein DJ, Van Heerden BB, Hugo C, Van Kradenburg J, Warwick J, Zungu-Dirwayi N, Seedat S. Functional brain imaging and pharmacotherapy in trichotillomania: Single photon emission computed tomography before and after treatment with the selective serotonin reuptake inhibitor citalopram. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2002;26:885-890 13. Sathekge M, Warwick J. Letter to the Editor: “Nuclear Medicine in South Africa”. South African Medical Journal 2003;93:88-90 14. Seedat S, Warwick J, Van Heerden BB, Hugo C, Zungu-Dirwayi N, Van Kradenburg J, Stein DJ. Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with the selective serotonin reuptake inhibitor citalopram. Journal of Affective Disorders 2004;80:45-53 15. Warwick JM. Imaging of brain function using SPECT. Metabolic Brain Disease, 2004;19:113- 123 16. Carey PD, Warwick J, Harvey BH, Stein DJ, Seedat S. Single photon emission computed tomography of obsessive-compulsive disorder before and after treatment with Inositol. Metabolic Brain Disease 2004;19:125-134 2 17. Carey P, Seedat S, Warwick J, Van Heerden B, Stein D SPECT Imaging of body dysmorphic disorder. Journal of Neuropsychiatry and Clinical Neuroscience 2004;16:357-359 18. Carey PD, Warwick J, Niehaus DJH, Van der Linden G, Van Heerden BB, Harvey BH, Seedat S, Stein DJ. Single photon computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram. BMC Psychiatry 2004;4:30 19. Möller J, Warwick J, Bouma H. Miokardiale Perfusiebeelding met Tc-99m MIBI in pasiënte met linker Bondeltakblok : Die visuële en kwantitiewe beoordeling van anteroseptale perfusie vir die diagnose van linker afdalende arterie stenose. Cardiovascular Journal of South Africa 2005;16:95-101 20. Van Toorn R, Rabie H, Warwick J. Opsoclonus myoclonus-associated immune reconstitution syndrome in a HIV infected child. European Journal of Paediatric Neurology 2005;9:423-6 21. Sathekge MM, Warwick J, Vangu MDT, Ellmann A, Mann M. A Case for the Provision of Positron Emission Tomography (PET) in South African Public Hospitals South African Medical Journal 2006;96:598-601 22. Stein DJ, Carey PD, Warwick J. Beauty or Beast: Psychobiologic and Evolutionary Perspectives on Body Dysmorphic Disorder CNS Spectr 2006;11:419-422 23. Warwick JM, Carey P, Van der Linden G, Prinsloo C, Niehaus D, Seedat S, Dupont P, Stein DJ. A Comparison of the effects of citalopram and moclobemide on resting brain perfusion in Social Anxiety Disorder. Metabolic Brain Disease 2006;21:241-252. 24. Stein DJ, Daniels W, Emsley R, Harvey B, Blackburn J, Carey P, Ellis G, Illing N, Flisher A, Moolman-Smook H, Mwaba K, Ramesar R, Russell V, Seedat S, Tredoux C, Vaughan CL, Vythilingum B, Warwick J. A brain-behaviour initiative for South Africa: the time is right. Metabolic Brain Disease 2006;21:279-284. 25. Warwick JM, Ellmann A, Hough FS. Positron emission tomography (PET) in endocrine tumours. JEMDSA 2007;12:18-23 26. Elmadani AE, Warwick JM, Ellmann A. The contribution of bone SPECT to the diagnosis of bone metastases in an African population. Nuclear Medicine Communications 2008;29:254- 259. 27. Warwick JM, Carey P, Jordaan GP, Dupont P, Stein D. Resting Brain Perfusion in Social Anxiety Disorder: a Voxel-wise whole brain comparison with healthy control subjects. Progress in Neuropsychopharmacology & Biological Psychiatry 2008;32:1251-1256. 28. Dupont PD, Warwick JM. Kinetic modelling in small animal imaging with PET. Methods 2009;48:98-103. 29. Jordaan GP, Warwick JM, Hewlett R, Emsley R. Resting brain perfusion in alcohol-induced psychotic disorder: a comparison in patients with alcohol dependence, schizophrenia and healthy controls. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2010;34:479-485. 30. Ndlovu X, George R, Ellmann A, Warwick JM. Should SPECT-CT replace SPECT for the evaluation of equivocal bone scan lesions in patients with underlying malignancies ? Nuclear Medicine Communications 2010;31:659-665. 31. Cassimjee N, Burnett M, Lochner C, Warwick J, Dupont P, Stein DJ, Cloete K, Carey PD. Changes in regional brain volumes in social anxiety disorder following 12 weeks of treatment with escitalopram. Metabolic Brain Disease 2010;25:369-374. 32. Warwick JM, Sathekge MM. PET/CT scanning with a high HIV/AIDS prevalence. Transf Apheres Sci 2011;44:167–172. 33. Warwick JM, Rubow S, Du Toit M, Beetge E, Carey P, Dupont P. The role of CT based attenuation correction and collimator blurring correction in striatal SPECT quantification. International Journal of Molecular Imaging. 2011;2011:Article ID 195037, 9 pages 34. Ding J, Chen H, Liao W, Warwick JM, Duan X, Qiu C, Zhang W, Gong Q. Disrupted Functional Connectivity in Social Anxiety Disorder: A Resting State fMRI Study. Magn Reson Imaging 2011;29:701-711. 35. Jordaan GP, Warwick JM, Nel DG, Hewlett R, Emsley R. Alcohol-induced Psychotic Disorder: Brain Perfusion and Psychopathology – before and after Anti-Psychotic Treatment. Metabolic Brain Disease 2012;27:67-77. 36. Warwick JM, Carey PD, Cassimjee N, Lochner C, Hemmings S, Moolman-Smook H, Beetge E, Dupont P, Stein DJ. Dopamine Transporter Binding in Social Anxiety Disorder: the effect of Treatment with Escitalopram. Metabolic Brain Disease 2012;27:151-158.