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Biochemistry and the Genomic Revolution 1.1
Dedication About the authors Preface Tools and Techniques Clinical Applications Molecular Evolution Supplements Supporting Biochemistry, Fifth Edition Acknowledgments I. The Molecular Design of Life 1. Prelude: Biochemistry and the Genomic Revolution 1.1. DNA Illustrates the Relation between Form and Function 1.2. Biochemical Unity Underlies Biological Diversity 1.3. Chemical Bonds in Biochemistry 1.4. Biochemistry and Human Biology Appendix: Depicting Molecular Structures 2. Biochemical Evolution 2.1. Key Organic Molecules Are Used by Living Systems 2.2. Evolution Requires Reproduction, Variation, and Selective Pressure 2.3. Energy Transformations Are Necessary to Sustain Living Systems 2.4. Cells Can Respond to Changes in Their Environments Summary Problems Selected Readings 3. Protein Structure and Function 3.1. Proteins Are Built from a Repertoire of 20 Amino Acids 3.2. Primary Structure: Amino Acids Are Linked by Peptide Bonds to Form Polypeptide Chains 3.3. Secondary Structure: Polypeptide Chains Can Fold Into Regular Structures Such as the Alpha Helix, the Beta Sheet, and Turns and Loops 3.4. Tertiary Structure: Water-Soluble Proteins Fold Into Compact Structures with Nonpolar Cores 3.5. Quaternary Structure: Polypeptide Chains Can Assemble Into Multisubunit Structures 3.6. The Amino Acid Sequence of a Protein Determines Its Three-Dimensional Structure Summary Appendix: Acid-Base Concepts Problems Selected Readings 4. Exploring Proteins 4.1. The Purification of Proteins Is an Essential First Step in Understanding Their Function 4.2. Amino Acid Sequences Can Be Determined by Automated Edman Degradation 4.3. Immunology Provides Important Techniques with Which to Investigate Proteins 4.4. Peptides Can Be Synthesized by Automated Solid-Phase Methods 4.5. -
One False Move for Years, Investing Legend DAVID BONDERMAN Could Do No Wrong. and Then He Tried to Buy a Utility from Enron. By
One False Move For years, investing legend DAVID BONDERMAN could do no wrong. And then he tried to buy a utility from Enron. By NICHOLAS VARCHAVER April 4, 2005 (FORTUNE Magazine) – THEY'RE THE KINGS of American business these days. Private equity firms, hedge funds, and their cash-laden ilk have been pulling the levers of capitalism, with investors you've never heard of amassing billions and buying corporate icons like Sears. Among this extremely quiet species, David Bonderman is as dominant as they come. He has earned a reputation as a master dealmaker, a tornado of a man spinning equal parts brilliance, energy, and charm inside his ever-moving vortex. His private equity partnership, Texas Pacific Group, has massive throw-weight. The firm says it has $20 billion under management--a gaudy sum that includes a series of under-the-radar Texas Pacific affiliates in the U.S. and Asia. That war chest puts the firm in the top tier of buyout funds and dwarfs those of raiders like Carl Icahn or even hedge fund upstarts like Eddie Lampert. Just in the U.S., Texas Pacific controls companies with annual revenues of $35 billion. If it were a public company, it would rank at No. 51 on the FORTUNE 500, somewhere between Motorola and Lockheed Martin. Like any private equity firm, Texas Pacific, which is based in Fort Worth and San Francisco, gathers cash from pension funds and wealthy investors and uses it to buy control of companies. What sets it apart from its peers is its reputation for taking on risky, unfixable companies--and then devoting serious resources to fixing them. -
Biographical References for Nobel Laureates
Dr. John Andraos, http://www.careerchem.com/NAMED/Nobel-Biographies.pdf 1 BIOGRAPHICAL AND OBITUARY REFERENCES FOR NOBEL LAUREATES IN SCIENCE © Dr. John Andraos, 2004 - 2021 Department of Chemistry, York University 4700 Keele Street, Toronto, ONTARIO M3J 1P3, CANADA For suggestions, corrections, additional information, and comments please send e-mails to [email protected] http://www.chem.yorku.ca/NAMED/ CHEMISTRY NOBEL CHEMISTS Agre, Peter C. Alder, Kurt Günzl, M.; Günzl, W. Angew. Chem. 1960, 72, 219 Ihde, A.J. in Gillispie, Charles Coulston (ed.) Dictionary of Scientific Biography, Charles Scribner & Sons: New York 1981, Vol. 1, p. 105 Walters, L.R. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 328 Sauer, J. Chem. Ber. 1970, 103, XI Altman, Sidney Lerman, L.S. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 737 Anfinsen, Christian B. Husic, H.D. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 532 Anfinsen, C.B. The Molecular Basis of Evolution, Wiley: New York, 1959 Arrhenius, Svante J.W. Proc. Roy. Soc. London 1928, 119A, ix-xix Farber, Eduard (ed.), Great Chemists, Interscience Publishers: New York, 1961 Riesenfeld, E.H., Chem. Ber. 1930, 63A, 1 Daintith, J.; Mitchell, S.; Tootill, E.; Gjersten, D., Biographical Encyclopedia of Scientists, Institute of Physics Publishing: Bristol, UK, 1994 Fleck, G. in James, Laylin K. (ed.), Nobel Laureates in Chemistry 1901 - 1992, American Chemical Society: Washington, DC, 1993, p. 15 Lorenz, R., Angew. -
Antibodies with Some Bite Antibodies Have Yet to Be Determined, It Is Reasonable to Suppose That the Ester Or David E
-~-------------------------------------N8NSANDVIEWS----------------_N_A_TU_R_E_V-O_L_._32_5_22_J_A_N_U_A_RY__ 19~87 Enzyme catalysis kinetics and is subject to competitive inhibition. Although the detailed chemical mechanisms of these catalytic Antibodies with some bite antibodies have yet to be determined, it is reasonable to suppose that the ester or David E. Hansen carbamate is strained towards a tetra hedral geometry on binding, thus facilitat THE spectacular specificities and rate William Jencks', more directly, stated in ing the attack of the hydroxide ion. Fur enhancements of enzymes are without 1969 thermore, the Scripps group has already equal among all known catalysts. It is no If complementarity between active site and found that their antibody can act via both wonder then that the design of new en transition state contributes significantly to nucleophilic and general base catalysis, zymes has long been a goal of biochemists. enzyme catalysis, it should be possible to syn depending on the substrate used. Now two independent groups, one led by thesize an enzyme by constructing a binding The fact that this approach succeeded at Alfonso Tramontano and Richard Lerner site. One way to do this is to prepare an anti all gives great hope to those attempting to of the Scripps Clinic and Research Foun body to a haptenic group which resembles the isolate even more efficient antibody cat dation', and the other by Peter Schultz of transition state of a given reaction. The com alysts by this and by other strategies. In the University of California at Berkeley\ bining sites of such antibodies should be com addition, it may be possible to modify have taken steps towards this goal by plementary to the transition state and should cause an acceleration by forcing bound sub existing catalytic antibodies. -
When We Unite
When We Unite 2020 Gratitude Report Letter from Leadership 2020 was a year unlike any other 02 as a global pandemic took hold, climate change picked up speed, racial injustice reached a new breaking point and a pivotal election consumed the nation. Our Refocused Mission: uniting people 04 to protect America’s wild places But in the face of extraordinary challenges, we understood that backing down wasn’t an option—and that when we unite, we hold the power to build solutions 06 Making Enduring Progress for a flourishing future that’s shared by all. In a critical year when the world felt the full weight of mounting crises, you Solving Urgent Crises 10 showed what it could look like when we come together, find common ground and take bold action to fulfill the promise of public lands for all. 14 Fulfilling the Promise of Public Lands for All 18 Our Supporters 38 Financials 40 The Wilderness Society Action Fund Cover image: Red Cliffs National Conservation Area, Utah Canyonlands National Park, Utah Michelle Craig Benj Wadsworth 1 In particular, we acknowledged Indigenous peoples as the longest 2020: Battling current threats serving stewards of the land and increased our efforts to seek their and charting the course for guidance and partnership in ways that share power, voice and impact. In 2020, we joined forces with more partners than ever before to transformational change ensure that public lands equitably benefit all people, that their potential to help address the great crises facing our nation are After four very challenging years for conservation, hope for a unleashed, and that we unite in a more inclusive and far more powerful sustainable future was renewed in November 2020 by the election conservation movement. -
Annual Report 2017
IDEAS LEADERSHIP ACTION OUR MISSION 2 Letter from Dan Porterfield, President and CEO WHAT WE DO 6 Policy Programs 16 Leadership Initiatives 20 Public Programs 26 Youth & Engagement Programs 30 Seminars 34 International Partnerships 38 Media Resources THE YEAR IN REVIEW 40 2017-2018 Selected Highlights of the Institute's Work 42 Live on the Aspen Stage INSTITUTIONAL ADVANCEMENT 46 Capital Campaigns 48 The Paepcke Society 48 The Heritage Society 50 Society of Fellows 51 Wye Fellows 52 Justice Circle and Arts Circle 55 Philanthropic Partners 56 Supporters STATEMENT OF FINANCIAL POSITION 90 2017 Annual Report WHO WE ARE 96 Our Locations 98 Aspen Institute Leadership 104 Board of Trustees LETTER FROM DAN PORTERFIELD, PRESIDENT AND CEO A LETTER FROM PRESIDENT AND CEO DAN PORTERFIELD There is nothing quite like the Aspen Institute. It is In the years to come, the Aspen Institute will deepen an extraordinary—and unique—American institution. our impacts. It is crucial that we enhance the devel- We work between fields and across divides as a opment of the young, address the urgent challenges non-profit force for good whose mission is to con- of the future, and renew the ideals of democratic so- vene change-makers of every type, established and ciety. I look forward to working closely with our many emerging, to frame and then solve society’s most partners and friends as we write the next chapter on important problems. We lead on almost every issue the Institute’s scope and leadership for America and with a tool kit stocked for solution-building—always the world. -
The Man Who Built a Billion Dollar Fortune Off Pirates of The
February 22, 2019 The Man Who Built a Billion‐Dollar Fortune Off ‘Pirates of the Caribbean’ By Tom Metcalf ‘Top Gun’ producer joins Spielberg, Lucas in billionaire club CSI and ‘Pirates of the Caribbean’ franchises drive fortune Johnny Depp as Captain Jack Sparrow and Jerry Bruckheimer Photographer: Mark Davis/Getty Images While the glitz and glamour of show business will be on full display Sunday at the Academy Awards, one of Hollywood’s most successful producers will be merely a bystander this year. Don’t weep for Jerry Bruckheimer, however. The man behind classic acon films like “Top Gun” and “Beverly Hills Cop” has won a Hollywood status far rarer than an Oscar ‐‐ membership in the three‐comma club. While stars sll reap plenty of income, the real riches are reserved for those who control the content. The creaves who’ve vaulted into the ranks of billionairedom remains thin, largely the preserve of household names like Steven Spielberg and George Lucas, who had the wherewithal to enter film producon and se‐ cured rights to what they produced. Bruckheimer has been just as successful on the small screen, producing the “CSI: Crime Scene Invesgaon” franchise. He’s sll at it, with a pilot in the works for CBS and “L.A.’s Finest,” a spinoff of “Bad Boys,” for Char‐ ter Communicaons’ new Spectrum Originals, set to air in May. “Jerry is in a league all of his own,” said Lloyd Greif, chief execuve officer of Los Angeles‐based investment bank Greif & Co. “He’s king of the acon film and he’s enjoyed similar success in television.” The TV business is changing, with a new breed of streaming services such as Nelix Inc. -
Subject Categories
Subject Categories Click on a Subject Category below: Anthropology Archaeology Astronomy and Astrophysics Atmospheric Sciences and Oceanography Biochemistry and Molecular Biology Business and Finance Cellular and Developmental Biology and Genetics Chemistry Communications, Journalism, Editing, and Publishing Computer Sciences and Technology Economics Educational, Scientific, Cultural, and Philanthropic Administration (Nongovernmental) Engineering and Technology Geology and Mineralogy Geophysics, Geography, and Other Earth Sciences History Law and Jurisprudence Literary Scholarship and Criticism and Language Literature (Creative Writing) Mathematics and Statistics Medicine and Health Microbiology and Immunology Natural History and Ecology; Evolutionary and Population Biology Neurosciences, Cognitive Sciences, and Behavioral Biology Performing Arts and Music – Criticism and Practice Philosophy Physics Physiology and Pharmacology Plant Sciences Political Science / International Relations Psychology / Education Public Affairs, Administration, and Policy (Governmental and Intergovernmental) Sociology / Demography Theology and Ministerial Practice Visual Arts, Art History, and Architecture Zoology Subject Categories of the American Academy of Arts & Sciences, 1780–2019 Das, Veena Gellner, Ernest Andre Leach, Edmund Ronald Anthropology Davis, Allison (William Gluckman, Max (Herman Leakey, Mary Douglas Allison) Max) Nicol Adams, Robert Descola, Philippe Goddard, Pliny Earle Leakey, Richard Erskine McCormick DeVore, Irven (Boyd Goodenough, Ward Hunt Frere Adler-Lomnitz, Larissa Irven) Goody, John Rankine Lee, Richard Borshay Appadurai, Arjun Dillehay, Tom D. Grayson, Donald K. LeVine, Robert Alan Bailey, Frederick George Dixon, Roland Burrage Greenberg, Joseph Levi-Strauss, Claude Barth, Fredrik Dodge, Ernest Stanley Harold Levy, Robert Isaac Bateson, Gregory Donnan, Christopher B. Greenhouse, Carol J. Levy, Thomas Evan Beall, Cynthia M. Douglas, Mary Margaret Grove, David C. Lewis, Oscar Benedict, Ruth Fulton Du Bois, Cora Alice Gumperz, John J. -
President's Report 2018
VISION COUNTING UP TO 50 President's Report 2018 Chairman’s Message 4 President’s Message 5 Senior Administration 6 BGU by the Numbers 8 Building BGU 14 Innovation for the Startup Nation 16 New & Noteworthy 20 From BGU to the World 40 President's Report Alumni Community 42 2018 Campus Life 46 Community Outreach 52 Recognizing Our Friends 57 Honorary Degrees 88 Board of Governors 93 Associates Organizations 96 BGU Nation Celebrate BGU’s role in the Israeli miracle Nurturing the Negev 12 Forging the Hi-Tech Nation 18 A Passion for Research 24 Harnessing the Desert 30 Defending the Nation 36 The Beer-Sheva Spirit 44 Cultivating Israeli Society 50 Produced by the Department of Publications and Media Relations Osnat Eitan, Director In coordination with the Department of Donor and Associates Affairs Jill Ben-Dor, Director Editor Elana Chipman Editorial Staff Ehud Zion Waldoks, Jacqueline Watson-Alloun, Angie Zamir Production Noa Fisherman Photos Dani Machlis Concept and Design www.Image2u.co.il 4 President's Report 2018 Ben-Gurion University of the Negev - BGU Nation 5 From the From the Chairman President Israel’s first Prime Minister, David Ben–Gurion, said:“Only Apartments Program, it is worth noting that there are 73 This year we are celebrating Israel’s 70th anniversary and Program has been studied and reproduced around through a united effort by the State … by a people ready “Open Apartments” in Beer-Sheva’s neighborhoods, where acknowledging our contributions to the State of Israel, the the world and our students are an inspiration to their for a great voluntary effort, by a youth bold in spirit and students live and actively engage with the local community Negev, and the world, even as we count up to our own neighbors, encouraging them and helping them strive for a inspired by creative heroism, by scientists liberated from the through various cultural and educational activities. -
Thermodynamic and Extrathermodynamic Requirements of Enzyme Catalysis
Biophysical Chemistry 105 (2003) 559–572 Thermodynamic and extrathermodynamic requirements of enzyme catalysis Richard Wolfenden* Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, USA Received 24 October 2002; received in revised form 22 January 2003; accepted 22 January 2003 Abstract An enzyme’s affinity for the altered substrate in the transition state (symbolized here as S‡) matches the value of kcatyK m divided by the rate constant for the uncatalyzed reaction in water. The validity of this relationship is not affected by the detailed mechanism by which any particular enzyme may act, or on whether changes in enzyme conformation occur on the path to the transition state. It subsumes potential effects of substrate desolvation, H- bonding and other polar attractions, and the juxtaposition of several substrates in a configuration appropriate for reaction. The startling rate enhancements that some enzymes produce have only recently been recognized. Direct measurements of the binding affinities of stable transition-state analog inhibitors confirm the remarkable power of binding discrimination of enzymes. Several parts of the enzyme and substrate, that contribute to S‡ binding, exhibit extremely large connectivity effects, with effective relative concentrations in excess of 108 M. Exact structures of enzyme complexes with transition-state analogs also indicate a general tendency of enzyme active sites to close around S‡ in such a way as to maximize binding contacts. The role of solvent water in these binding equilibria, for which Walter Kauzmann provided a primer, is only beginning to be appreciated. ᮊ 2003 Elsevier Science B.V. All rights reserved. -
The Regental Laureates Distinguished Presidential
REPORT TO CONTRIBUTORS Explore the highlights of this year’s report and learn more about how your generosity is making an impact on Washington and the world. CONTRIBUTOR LISTS (click to view) • The Regental Laureates • Henry Suzzallo Society • The Distinguished Presidential Laureates • The President’s Club • The Presidential Laureates • The President’s Club Young Leaders • The Laureates • The Benefactors THE REGENTAL LAUREATES INDIVIDUALS & ORGANIZATIONS / Lifetime giving totaling $100 million and above With their unparalleled philanthropic vision, our Regental Laureates propel the University of Washington forward — raising its profile, broadening its reach and advancing its mission around the world. Acknowledgement of the Regental Laureates can also be found on our donor wall in Suzzallo Library. Paul G. Allen & The Paul G. Allen Family Foundation Bill & Melinda Gates Bill & Melinda Gates Foundation Microsoft DISTINGUISHED PRESIDENTIAL LAUREATES INDIVIDUALS & ORGANIZATIONS / Lifetime giving totaling $50 million to $99,999,999 Through groundbreaking contributions, our Distinguished Presidential Laureates profoundly alter the landscape of the University of Washington and the people it serves. Distinguished Presidential Laureates are listed in alphabetical order. Donors who have asked to be anonymous are not included in the listing. Acknowledgement of the Distinguished Presidential Laureates can also be found on our donor wall in Suzzallo Library. American Heart Association The Ballmer Group Boeing The Foster Foundation Jack MacDonald* Robert Wood Johnson Foundation Washington Research Foundation * = Deceased Bold Type Indicates donor reached giving level in fiscal year 2016–2017 1 THE PRESIDENTIAL LAUREATES INDIVIDUALS & ORGANIZATIONS / Lifetime giving totaling $10 million to $49,999,999 By matching dreams with support, Presidential Laureates further enrich the University of Washington’s top-ranked programs and elevate emerging disciplines to new heights. -
Lawyer Fall 2016
161882_Cover_TL-25coverfeature.qxp 9/15/16 8:12 PM Page CvrA TULANE UNIVERSITY LAW SCHOOL TULANE VOL.32–NO. 1 LAWYER FALL 2016 CHARMS CHALLENGES& ALUMNI IRRESISTIBLY PULLED BACK TO NEW ORLEANS ALSO INSIDE BLOGGING PROFESSORS LAW REVIEW CENTENNIAL DIVERSITY ENDOWMENT 161882_Cover_TL-25coverfeature.qxp 9/15/16 8:12 PM Page CvrB THE DOCKET 1 FRONT-PAGE FOOTNOTES 13 2 DEAN MEYER’S MEMO 3 BRIEFS 5 REAL-WORLD APPS Hands-on Learning 7 WORK PRODUCT Faculty Scholarship FOUR FIVE NEW PROFESSORSHIPS AWARDED. FACULTY TEST IDEAS THROUGH BLOGGING. SCHOLARLY WORK SPANS THE GLOBE. 13 CASE IN POINT CHARMS & CHALLENGES Alumni irresistibly pulled back to New Orleans 22 LAWFUL ASSEMBLY Events & Celebrations 27 RAISING THE BAR Donor Support NEW GRADS PROMOTE DIVERSITY. NEW SCHOLARSHIPS IN LITIGATION, BUSINESS, CIVIL LAW. GIFT ENHANCES CHINA INITIATIVES. 39 CLASS ACTIONS Alumni News & Reunions TULANE REMEMBERS JOHN GIFFEN WEINMANN. RIGHT: The 2016-17 LLMs and international students show their Tulane Law pride. Update your contact information at tulane.edu/alumni/update. Find us online: law.tulane.edu facebook.com/TulaneLawSchool Twitter: @TulaneLaw bit.ly/TulaneLawLinkedIn www.youtube.com/c/TulaneLaw FALL 2016 TULANE LAWYER VOL.32–NO.1 161882_01-2_TL-25coverfeature.qxp 9/15/16 7:19 PM Page 1 FRONT-PAGE FOOTNOTES CLASS PORTRAIT TULANE LAW SCHOOL CLASS OF 2019 198 students 100+ colleges/universities represented 34 U.S. jurisdictions represented THE CLASS OF 2019 INCLUDES: A speechwriter for a South American country’s mission at the United Nations age range 20–52