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(12) Patent Application Publication (10) Pub. No.: US 2011/0206750 A1 Den Brave Et Al US 201102.06750A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/0206750 A1 Den Brave et al. (43) Pub. Date: Aug. 25, 2011 (54) NOVEL COSMETIC ORDERMATOLOGICAL Publication Classification COMPOSITIONS (51) Int. Cl. A6IR 8/29 (2006.01) (76) Inventors: Kerstin Den Brave, Basel (CH): A6IR 8/02 (2006.01) Heidi Moser, Bubendort (CH): A6IR 8/92 (2006.01) Horst Westenfelder, Neustadt A6IR 8/58 (2006.01) a.d.W (DE) A6IR 8/60 (2006.01) A6IR 8/35 (2006.01) (21) Appl. No.: 13/058,247 A6IR 8/34 (2006.01) A6IR 8/55 (2006.01) A6IR 8/36 (2006.01) (22) PCT Fled: Aug. 18, 2009 A61O 19/04 (2006.01) A61O 1704 (2006.01) (86) PCT NO.: PCT/EP09/60652 (52) U.S. Cl. ........................................... 424/401; 424/59 S371 (c)(1), (57) ABSTRACT (2), (4) Date: May 3, 2011 The present invention relates to novel cosmetic or dermato logical compositions comprising at least one specific titanium (30) Foreign Application Priority Data dioxide and at least one self-tanning agent and a cosmetically acceptable carrier. The compositions are in particular Suitable Aug. 19, 2008 (EP) .................................. O81626O12 for artificial/sunless tanning and/or browning of human skin. US 2011/0206750 A1 Aug. 25, 2011 NOVEL COSMETIC ORDERMATOLOGICAL dioxide. Furthermore, the invention relates to the use of such COMPOSITIONS compositions for artificial/sunless tanning and/or browning of human skin. 0008. The invention also relates to the topical application 0001. The present invention relates to novel cosmetic or of compositions according to the invention for the coloring/ dermatological compositions comprising at least one specific browning of the skin to impart an appearance similar to natu titanium dioxide and at least one self-tanning agent and a ral tanning of the skin, for enhancement of the natural glow of cosmetically acceptable carrier. The compositions are in par the skin and/or to provide a healthy appearance. ticular Suitable for artificial/sunless tanning and/or browning 0009. The present invention also relates to a method for of human skin. artificially tanning or browning of the skin said method com 0002. By the term “self-tanning agent' or “artificial/sun prising the topical application of an effective amount of a less tanning agent” are intended agents which, when topically composition according to the invention. applied onto the skin, in particular onto the face, elicit a 0010 Furthermore, the invention relates to the use of at tanning effect with an appearance more or less similar to that least one certain titanium dioxide for improving the stability resulting from prolonged exposure to the Sun (natural tan and/or for enhancing the coloring capability of a self-tanning ning) or under a UV lamp. agent. 0003. It is today important to look well and a tanned skin 0011. The term effective amount as used herein refers to is always a sign of good health. However, natural tanning is an amount necessary to obtain a physiological effect. The not always desirable insofar as it requires prolonged exposure physiological effect may beachieved by one single dose or by to UV radiation which causes browning of the skin but, on the repeated doses. The dosage administered may, of course, vary other hand, induces skin damages such as increased wrin depending upon known factors, such as the physiological kling, elastosis, pigmentary changes, precancerous and can characteristics of the particular composition and its mode and cerous skin lesions. Thus, it is desirable to have an alternative route of administration; the age, health and weight of the to natural tanning. Therefore, self-tanning ingredients are recipient; the nature and extent of the symptoms; the kind of gaining more importance for various applications in the skin concurrent treatment; the frequency of treatment; and the and Sun care market. In addition to the classic self-tanners effect desired and can be adjusted by a person skilled in the there are, for example, moisturizing preparations for face and art. body that gradually build up a very slight and discreet tan, after-Sun preparations that prolong the tan, or Sunscreens 0012. The titanium dioxide which can be used according containing self-tanning ingredients. to the invention can be any titanium dioxide suitable for 0004. The majority of cosmetic products for the artificial cosmetic applications. tanning of the skin are based on carbonyl derivatives which 0013. In one embodiment, the titanium dioxide used in the permit the formation of colored compounds by interaction compositions according to the invention is Substantially free with the amino acids of the skin. These compounds include of any aluminium coating as this leads to a more pronounced mono- or polycarbonyl compounds, such as, for example, discoloration of the cosmetic ordermatological compositions isatin, alloxan, ninhydrin, glyceraldehyde, mesotartaric alde compared to the use of titanium dioxide grades having no hyde, glutaraldehyde, erythrulose and dihydroxyacetone aluminium coating. (DHA). 0014 “Substantially free”, as used herein, is understood to 0005 Combinations of UV-filters with self-tanning ingre mean completely free of said coating, or inclusive of trace dients are desirable products in today's cosmetic field. How amounts of same. “Trace amounts are those quantitative ever, the combination of typical self-tanning ingredients such levels of a chemical constituent that are barely detectable and as erythrulose or dihydroxyacetone (DHA) with UV-filters, provide no benefit to the functional or aesthetic properties of particularly with inorganic UV-filters, is still a difficult task the subject composition. Particularly, the titanium dioxide due to the chemical properties of these substances. In particu used according to the invention is completely free of any lar the combination of inorganic pigments such as Zinc oxide aluminium coating, meaning that the titanium dioxide has not or titanium dioxide with self tanning ingredients such as been brought into contact with aluminium or an aluminium erythrulose or DHA often leads to an unwanted brown dis compound usually used for this kind of coating. coloration of the composition. Also, there is an ongoing need 0015. In a preferred embodiment, the titanium dioxide is for self-tanning products which act rapidly and impart a col coated with an organic coating Such as e.g. selected from oration similar to natural tanning. polyols, methicone, or alkyl silane. Such coatings are well 0006. It has now surprisingly been found, that the combi known in the art. Commercially available organic coated nation of certain titanium dioxides with a self tanning agent in titanium dioxides Suitable according to the invention are e.g. cosmetic compositions overcomes the shortcomings of the available as Uvinul R. TiO, by BASF or Eusolex(RT-Avo by prior art by significantly improving the stability of the com Merck. positions, reducing the discoloration of the formulations 0016. In a particular preferred embodiment, the titanium while showing an enhanced transparency, thus avoiding the dioxide is coated with an organic coating selected from silica, so called whitening effect on the skin. Furthermore, the silicone oils (e.g. Simethicones, methicones, dimethicones, colorations provided are more chromatic, more stable over polysilicone-15) or alkyl silanes. Commercially available time and have good homogeneity. organic coated titanium dioxides particularly Suitable accord 0007 Thus, the invention relates to a cosmetic composi ing to the invention are e.g. available as Uvinul R. TiO (INCI: tion comprising an effective amount of at least one artificial/ trimethoxycaprylylsilane and titanium dioxide ex BASF) or Sunless tanning agent, and an effective amount of titanium Eusolex(RT-Avo (INCI: Titanium dioxide, Silica ex Merck). US 2011/0206750 A1 Aug. 25, 2011 0017. In another embodiment the titanium dioxide is a 0024. The crystalline form of the titanium dioxide may be non-coated titanium dioxide Suitable for cosmetic applica of any crystal or amorphous type. For example, titanium tions such as pyrogenic titanium dioxide (e.g. AEROXIDE dioxide may be any type of amorphous, rutil, anastase, broo P25 ex Degussa). kite or a mixture thereof. 0025. The titanium dioxide is generally present in the 0018. In a more particular embodiment of the invention, compositions according to the invention in proportions rang the titanium dioxide is a double coated titanium dioxide hav ing from about 0.5 to about 50% by weight, preferably from ing an inner inorganic silica coating and an outer organic about 1 to 25 wt.% in particular from about 1 to 10 wt.-%. coating (referred to as double coated titanium dioxide). Such 0026. In a particular embodiment the ratio (w/w) of the coated titanium dioxides nanoparticles can be prepared self-tanning agent to the titanium dioxide is selected in the according to the state of the art or are commercially available range of 0.1:1 to 1:0.1, such as in particular 0.5:1 to 1:0.5, as PARSOL(R) TX (INCI of ingredient: Titanium Dioxide, most in particular in the range of 1:1. Silica, Dimethicone (C2H6OSi)xC4H12Si ex DSM Nutri 0027 Thus, the invention in particular relates to compo tional Products) or as UV-Titan X195 (coated with silica and sitions comprising a double coated titanium dioxide having treated with a silicone oil (i.e. methicone) ex Kemira). an inner silica coating and an outer coating selected from 0019. The inner coating of the titanium dioxide particle dimethicone or methicone, in particular dimethicone, and with inorganic silica can be prepared according to the state of erythrulose and/or DHA as self tanning agent, wherein the the art as e.g. described in EP-A 988 853, EP-A 1284 277, ratio (w/w) of the self-tanning agent to the titanium dioxide is EP0988853, and U.S. Pat. No. 5,562,897, JP 2000319128. selected in the range of 0.5:1 to 1:0.5, such as in particular in 0020.
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