DOCSLIB.ORG

Research Report 2012 / 2013

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Research Report 2012 / 2013 Julius Wolff Institute in collaboration with the Center for Musculoskeletal Surgery Research Report 2012 / 2013 Julius Wolff Institute in collaboration with the Center for Musculoskeletal Surgery Research Report 2012 / 2013 Welcome With enthusiasm, we look back on two and a half years of exciting research at the Julius Wolff Institute. Recent research findings, be it the surprisingly high in vivo friction moments in total hip replacements, the essential role of TEMRA cells as “bad guys” in bone regeneration or the role of biomaterial as guiding structure in tissue regeneration, showed an essential impact on the understanding in musculoskeletal science on a global scale. Examples of the later are the first completed phase I-IIa clinical trial on stem cells for muscle regeneration or the assessment of a specific implant failure with a recent re- launch of that implant after mechano-biological optimization. As institution, we feel obliged to continue working on both the basic re- Univ.-Prof. Dr.-Ing. Prof. Dr.-Ing. search side as well as on clinical research aspects to building bridges Georg N. Duda Georg Bergmann between a basic research understanding and the translational aspects of musculoskeletal sciences (see http://translate-event.charite.de, jointly with the journal Science Translational Medicine). We are very proud that our intention to stabilize the institute and continue with a highly dedicated team of scientists was granted with positive reviews of not only the existing programs of the DFG graduate school BSRT and the translational research center BCRT but also with the funding of two major new initiatives, the BMBF research networks on osteoarthritis (OVERLOAD/ PrevOP) and osteoporosis (OSTEOPATH) as well as our DFG research group on regeneration in aged patients (FG 2165). 4 5 Of particular importance was that two members of our core team in Berlin To improve further these interactions, we founded the OrthoLoadClub, a forum Markus O. Heller and William R. Taylor received calls on professorships dur- of continued discussion on biomechanics and musculoskeletal loading with ing the last years from world-renowned institutions in University of South- most of our commercial partners. The club proved so far to be an extremely ampton and ETH Zurich. We are very happy for both of them, look forward valuable tool of joint or bi-lateral discussions on the importance of in vivo to continued interaction now on an European level and whish them all the forces and their consequences to patients and the global public. This together success they deserve. Further, we are excited that we could complement our with the continued support by the Charité, the German Research Foundation team at Julius Wolff with the start of Prof Frank Witte on the DePuy-Synthes (DFG), the various Federal Ministries and the European Commission make our sponsored professorship on resorbable biomaterials. Profs Britt Wildemann work possible. and Kay Raum have seen very positive evaluations by the faculty and continue their work in our team. We thank everyone who has been involved in our activities for their interest, support and encouragement during the last years and we very much hope that In addition, we are very proud that Prof. Georg Matziolis has been called as the information in this research report will be of interest and of use to you. the youngest W3 in Germany on a chair in orthopedics in Jena and that a num- We look forward to continue this excellent co-operation. ber of Clinical Scientists have “completed” their training by very success- fully reaching their habilitation. We congratulate the most recent PDs Tobias Berlin, July 2014 Winkler, Patrick Strube and Bernd Preininger. Our comprehensive research activities and their structural and technical requirements were also made possible through continued support by our part- ners from industry and from public foundations. We are very proud of having you as partners, often based on long-standing, personal relationships. This interaction is especially important to bring our basic findings into products or solutions for musculoskeletal recovery or regeneration and reach a large Univ.-Prof. Dr.-Ing. Prof. Dr.-Ing. number of patients. Georg N. Duda Georg Bergmann Director Vice Director 6 7 Greetings from the Clinical Advisory Board It is remarkable to note that the field of musculoskeletal research experienced We have learned that a dedicated Clinical Scientist educational program is es- substantial increase in public awareness, both from patient representatives sential to support young clinical fellows early on a path towards an academic as well as from funding agencies. Especially the call of the BMBF to initiate career. Without the structured support of such education, only limited possi- Musculoskeletal Research Networks in Germany has given the field a more re- bilities do exist in nowadays-classical surgical department infrastructures. We markable, national visibility. We are proud that two of our initiatives were suc- are happy that the concept has been taken along into the DFG funded graduate cessful in this call. In addition, we could recently install a clinically motivated school BSRT and now as a concept of Clinical Scientists through the Berlin research group funded by the German Research Foundation. Taken together, Institute of Health across the whole Charité. We welcome that our example is these measures illustrate the general increase in awareness of the need to now discussed in the DFG Senatskommission Klinische Forschung. improve musculoskeletal science and treatment. Kapitelbezeichung JWI-Report Kapitelbezeichung 2011 The backbone of these activities is a personal tight interaction between us The challenges in musculoskeletal health for medical experts and the health at the Center for Musculoskeletal Surgery and our Julius Wolff Institute. With care system are growing enormously due to an aging population, changes in such tight interactions, musculoskeletal sciences have a realistic chance to lifestyles and the demographic changes in industrialised nations. Musculo- solve the unmet clinical needs that derive from the essential health care bur- skeletal disorders are now ranked top among global health threads, specifi- dens we aim to attack. cally if back pain, osteoporosis, arthrosis, sport injuries and traffic injuries are taken together. Disorders of the musculoskeletal system account for nearly Berlin, July 2014 half of all absences from work and sixty percent of permanent work incapacity in Europe. Our aim is to realize effective and application-related research that allows to prevent or regenerate musculoskeletal disorders or to improve cur- rent treatments of degenerative diseases. Over the years we have been able to realize an integrative model of basic and clinical research with joint research efforts at both the Julius Wolff Institute Univ.-Prof. Dr. med. Dr. h.c. Univ.-Prof. Dr. Univ.-Prof. Dr. and the Center for Musculoskeletal Surgery. We have developed modes of tight Norbert P. Haas Carsten Perka Klaus-Dieter Schaser interaction between Clinical Scientists and researchers in Engineering or Biol- Director Vice-Director Vice-Director ogy to thrive musculoskeletal science. of the Center for of the Center for of the Center for Musculoskeletal Surgery Musculoskeletal Surgery Musculoskeletal Surgery of the Charité (CMSC) of the Charité (CMSC) of the Charité (CMSC) 8 9 Table of Contents 4 Welcome 66 Muscle force transfer to a finite element model 114 Biophysical Cues and Tissue Organization 174 Mechanical regulation of bone healing 8 Greetings from the Clinical Advisory Board 67 Lumbar spinal loads and trunk muscle forces 116 Scaffold architecture and BMP timulations 176 Development of Mineralization 14 Synopsis 68 Simulation of lumbar disc nucleus replacements 118 3D tissue growth in-vivo under geometrical constraints 178 Maturation dynamics of the forming mouse femur 15 Developments at the JWI 2012 – mid 2014 70 In vivo / in vitro Measurements 120 Macroporous alginate hydrogels 180 High resolution non-contact full-field strain mapping 22 Julius Wolff Institute Structure 72 Spinal forces during lifting up a weight 122 Control Tissue Formation 182 Nano-particle strains in mechanically loaded dentine 24 News from the Research Network 73 Monitoring the load on a VBR 124 Scaffolds orf creating sharp tissue patterns 27 Clinical Scientists in Musculoskeletal Surgery 74 How does the back shape affects spinal loads? 184 Regeneration and Reconstruction 75 Effects of implant parameters on kinematics 126 Cell Biology 30 Loading and Movement 76 Dynamic assessment of the lumbar spine 186 Impaired Bone Healing & Tendon and 78 Motion and posture analysis at the workplace 128 Stem Cells for Muscular Regeneration Ligament Healing 32 Instrumented Implants 79 Age-related loss of lumbar lordosis and mobility 130 Mesenchymal stem cell for skeletal 188 A new antibiotics/bone graft mixing device 34 Reductions of the EAM cause muscle injuries 190 Gentamicin does not impair bone healing different effects on Fmed 80 Bone Healing 131 Improvement of contraction force in 192 Influence of a statin on implant integration 36 External vs. internal knee joint loading injured skeletal muscle via autologous 193 Hepatic osteodystrophy in Abcb4 deficient mice 38 Hip joint loading during different athletic activities 82 Biology of Bone Healing MSC-transplantation 194 β-TCP coated with Zoledronic Acid 39 Joint loading during whole body vibration training 84 Rewriting the story of the initial 134 Functional comparison
Load more

Recommended publications
  • Effect of the Combination of Ipriflavone and 1
    PEDIATRIC DENTAL JOURNAL 14(1): 5–15, 2004 5 Effect of the combination of ipriflavone and 1␣-OH-D3 on debilitant bone in growing rats —Ultrastructural study of endochondral ossification— Kazushige Ueda, Ikuko Nishida, Bin Xia, Iwan Tofani, Jianguo Wang, Yasuhiro Nishikawa and Mitsutaka Kimura Department of Pediatric Dentistry, Kyushu Dental College 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu City, Fukuoka 803-8580, JAPAN Abstract Five-week-old male Wistar rats were used to study the effect of Key words dietary therapy with ipriflavone combined with 1␣-OH-D3. Ultrastructural alter- 1␣-OH-D3, ations in the metaphysis of debilitated tibia were observed in the growing rats. Growing rats, I. Light microscopy findings Ipriflavone, In the low-calcium diet • standard diet with supplementary ipriflavone and Metaphysis tibia 1␣-OH-D3 group, calcification of the chondral matrix and ossification were active, and the tibia grew normally as in the control group. II. Scanning electron microscopy findings In the low-calcium diet • standard diet with supplementary ipriflavone and 1␣-OH-D3 group, dense calcospherites, distinct chondral lacunae, regularly running collagen fibers, and distinct border lines were noted. III. Transmission electron microscopy findings In the low-calcium diet • standard diet with supplementary ipriflavone and 1␣-OH-D3 group we found that the osteoblasts were active, the ruffled border of osteoclast was decrease, indicated this osteoclast is inactive. In conclusion, insufficient calcium intake during the developmental period resulted in debilitated(3etaphysis tibia, whereas dietary therapy using combined ipriflavone and 1␣-OH-D3 promoted recovery. Introduction patients become refractory after several days of administration, which is known as the calcitonin Recently dietary therapies, physiologic active sub- escape phenomenon, therefore, it is not considered stances, exercise, and/or bone resorption inhibitors a suitable therapy for osteoporosis3).
    [Show full text]
  • Nomina Histologica Veterinaria, First Edition
    NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria.
    [Show full text]
  • The Mechanoresponse of Bone Is Closely Related to the Osteocyte Lacunocanalicular Network Architecture
    The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture Alexander Franciscus van Tola,b,1, Victoria Schemenza,b, Wolfgang Wagermaiera, Andreas Roschgera,c, Hajar Razia, Isabela Vitienesd,e, Peter Fratzla, Bettina M. Willied,e, and Richard Weinkamera,1 aDepartment of Biomaterials, Max Planck Institute of Colloids and Interfaces, 14476 Potsdam, Germany; bBerlin-Brandenburg School for Regenerative Therapies, Charité–Universitätsmedizin Berlin, 13353 Berlin, Germany; cDepartment of Chemistry and Physics of Materials, Paris Lodron University of Salzburg, A-5020 Salzburg, Austria; dResearch Centre, Shriners Hospital for Children-Canada, Montreal, H4A 0A9, Canada; and eDepartment of Pediatric Surgery, McGill University, Montreal, H3A 0G4, Canada Edited by Lia Addadi, Weizmann Institute of Science, Rehovot, Israel, and approved November 1, 2020 (received for review June 4, 2020) Organisms rely on mechanosensing mechanisms to adapt to changes materials, where the fluid-filled network should impart self-healing in their mechanical environment. Fluid-filled network structures not properties to the material (10, 11). only ensure efficient transport but canalsobeemployedformecha- In bone, fluid flow occurs in the lacunocanalicular network nosensation. The lacunocanalicular network (LCN) is a fluid-filled net- (LCN), a porous network of micrometer-sized lacunae con- work structure, which pervades our bones and accommodates a cell nected by roughly 300-nm-wide canals, called canaliculi (12, 13). network
    [Show full text]
  • OSTEOCYTE SIGNALING and ITS EFFECTS on the ACTIVITES of OSTEOBLASTS and BREAST CANCER CELLS by Sina Ahandoust
    OSTEOCYTE SIGNALING AND ITS EFFECTS ON THE ACTIVITES OF OSTEOBLASTS AND BREAST CANCER CELLS by Sina Ahandoust A Thesis Submitted to the Faculty of Purdue University In Partial Fulfillment of the Requirements for the degree of Master of Science in Biomedical Engineering Department of Biomedical Engineering at IUPUI Indianapolis, Indiana May 2021 THE PURDUE UNIVERSITY GRADUATE SCHOOL STATEMENT OF COMMITTEE APPROVAL Dr. Sungsoo Na, Chair Department of Biomedical Engineering Dr. Hiroki Yokota Department of Biomedical Engineering Dr. Jiliang Li Department of Biology Approved by: Dr. Joseph Wallace 2 ACKNOWLEDGMENTS I would like to appreciate my supervisor, Dr. Sungsoo Na, for his guidance and support. This study would not be possible without his careful direction, expertise, experience and encouragement. I would also like to thank the members of my thesis advisory committee, Dr. Hiroki Yokota and Dr. Jiliang Li for their support throughout my project. Finally, I would like to appreciate my family and friends for their support during my graduate studies. 3 TABLE OF CONTENTS LIST OF FIGURES ........................................................................................................................ 5 LIST OF ABBREVIATIONS ......................................................................................................... 7 ABSTRACT .................................................................................................................................... 8 1. INTRODUCTION .................................................................................................................
    [Show full text]
  • Korean Knee Society Terminology Book For
    Korean Knee Society’s Terminology Book This edition first published 2015 © 2015 by Korean Knee Society. Published edition © 2015 Wiley Publishing Japan K.K. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the copyright owner. ISBN: 978-4-939028-29-8 Published by Wiley Publishing Japan K.K. Tokyo Office: Frontier Koishikawa Bldg. 4F, 1-28-1 Koishikawa, Bunkyo-ku, Tokyo 112-0002, Japan Telephone: 81-3-3830-1221 Fax: 81-3-5689-7276 Internet site: http://www.wiley.com/wiley-blackwell e-mail: [email protected] Printed and bound in Korea by JEIL PRINTECH 발 간 사 대부분의 의학 용어는 영어에서 유래되어 그 해석과 의미가 오 랜 시간 동안 계승 발전되어 왔습니다. 그러나 오랜 역사를 거 치면서 용어의 해석이 다양해져 교육 현장은 물론 임상에서도 여러 용어로 혼용되고 있어 ‘용어 통일’의 필요성이 지속적으로 대두되어 왔습니다. 이에 대한슬관절학회에서는 슬관절 분야 에서 많이 쓰이고 있는 용어들을 수집하여 용어를 재정비 하고 통일하는 사업을 추진하였습니다. 대한슬관절학회 교과서편찬위원회에서는 2013년 12월에 업무를 개시하여 1년 5 개월 동안 슬관절 분야의 대표적 영어 교과서의 색인, 대한정형외과학회 교과서 색 인 및 용어집, 대한슬관절학회 교과서 편찬시 논의 된 용어통일 리스트에서 용어를 수집하여 약 5,000 여개의 주요 용어를 정리하였습니다. 이번 용어 편찬 작업에서 주목할 만한 부분은 관련 전문가들은 물론 일반인들도 용 어 해석을 쉽게 찾아볼 수 있도록 어플리케이션을 제작하여 앱 스토어나 플레이 스 토어에서 무료로 다운로드 하여 볼 수 있도록 접근성을 높였다는 것입니다. 이번 용 어집 편찬 작업이 선생님들의 진료와 연구에 도움이 되고, 일반인들도 보다 쉽고 정 확하게 의료진들과 소통할 수 있길 바라며 앞으로 꾸준히 발전해 나갈 수 있도록 많 은 관심 바랍니다.
    [Show full text]
  • Imaging the Bone Cell Network with Nanoscale Synchrotron Computed Tomography Alexandra Joita Pacureanu
    Imaging the bone cell network with nanoscale synchrotron computed tomography Alexandra Joita Pacureanu To cite this version: Alexandra Joita Pacureanu. Imaging the bone cell network with nanoscale synchrotron computed tomography. Other. INSA de Lyon, 2012. English. NNT : 2012ISAL0001. tel-00778408 HAL Id: tel-00778408 https://tel.archives-ouvertes.fr/tel-00778408 Submitted on 20 Jan 2013 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. N° d’ordre 2012ISAL0001 Année 2012 Thèse Imaging the bone cell network with nanoscale synchrotron computed tomography Présentée devant L’Institut National des Sciences Appliquées de Lyon Pour obtenir Le grade de docteur ÉCOLE DOCTORALE ELECTRONIQUE, ELECTROTECHNIQUE, AUTOMATIQUE Par Alexandra PACUREANU Soutenue le 19 janvier 2012 devant la commission d’examen Jury P. Laugier Directeur de recherche CNRS UPMC Paris M. Garreau Professeur Université de Rennes 1 J. Klein-Nulend Professeur Université d’Amsterdam J.Y. Buffière Professeur INSA de Lyon M. Ciuc Maitre de Conférences Université Politehnica Bucarest C. Muller Maitre de Conférences INSA de Lyon V. Buzuloiu Professeur Université Politehnica Bucarest F. Peyrin Directeur de recherche INSERM INSA de Lyon Laboratoire de recherche CREATIS Cette thèse est accessible à l'adresse : http://theses.insa-lyon.fr/publication/2012ISAL0001/these.pdf © [A.
    [Show full text]
  • Shaking Stimuli Can Retard Accelerated Decline of Bone Strength of a Mouse Model Assumed to Represent a Postmenopausal Woman
    Journal of Analytical Bio-Science Vol. 33, No 4 (2010) 〈Original article〉 Shaking stimuli can retard accelerated decline of bone strength of a mouse model assumed to represent a postmenopausal woman Kouji Yamada*, Kazuhiro Nishii and Takehiko Hida Summary In contrast in elderly people, if bone formation and resorption are out of balance, bone mineral density (BMD) diminishes leading to progressive development of osteoporosis, a cause of easy bone fracture. Standing still for prolonged periods leads to fatigue. Humans tend to avoid this by shifting the body weight unconsciously or consciously left and right or back and forth. Standing in an erect posture on a board that continuously shakes horizontally causes all the skeletal muscles of the body as well as the entire skeleton to act to restore balance. As a result of the application of such shaking–induced stimuli to a reduced–BMD mouse model of postmenopausal osteoporosis, rapid decline in the bone strength of the femur was suppressed. A shaking stimulus such as was used in this study could easily be applied to human beings in future once further study is conducted to validate the results. Key words: Osteogenesis, Bone resorption, Shaking, Physical therapy 1. Introduction (BMD) continues to increase for a while after cessation of linear growth. Generally, bone mass in A rise in average longevity along with improved humans reaches a peak in the late twenties to thirties, treatment for organ disorders and various diseases remaining in a static state for some time thereafter. has rendered age-associated bone mass reduction a With further aging, bone volume is maintained but great clinical issue.
    [Show full text]
  • Recapitulating Cranial Osteogenesis with Neural Crest Cells in 3-D
    Acta Biomaterialia 31 (2016) 301–311 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments ⇑ Bumjin Namkoong a,b,1, Sinan Güven c,d,1, Shwathy Ramesan e, Volha Liaudanskaya c, Arhat Abzhanov a,f,g, ,2, ⇑ Utkan Demirci c,e, ,2 a Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA b Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA c Demirci BAMM Labs, Canary Center at Stanford for Early Cancer Detection, Department of Radiology, Department of Electrical Engineering (By courtesy), Stanford School of Medicine, Palo Alto, CA 94304, USA d Izmir Biomedicine and Genome Center, Dokuz Eylul University Health Campus, Balcova, 35350 Izmir, Turkey e Demirci BAMM Labs, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA f Current address: Department of Life Sciences, Imperial College London, Silwood Park Campus Buckhurst Road, Ascot, Berkshire SL5 7PY, United Kingdom g Current address: Natural History Museum, Cromwell Road, London SW7 5BD, United Kingdom article info abstract Article history: The experimental systems that recapitulate the complexity of native tissues and enable precise control Received 9 June 2015 over the microenvironment are becoming essential for the pre-clinical tests of therapeutics and tissue Received in revised form 11 November 2015 engineering. Here, we described a strategy to develop an in vitro platform to study the developmental Accepted 2 December 2015 biology of craniofacial osteogenesis. In this study, we directly osteo-differentiated cranial neural crest Available online 7 December 2015 cells (CNCCs) in a 3-D in vitro bioengineered microenvironment.
    [Show full text]
  • ISSN 0302-766X, Volume 340, Number 3
    ISSN 0302-766X, Volume 340, Number 3 This article was published in the above mentioned Springer issue. The material, including all portions thereof, is protected by copyright; all rights are held exclusively by Springer Science + Business Media. The material is for personal use only; commercial use is not permitted. Unauthorized reproduction, transfer and/or use may be a violation of criminal as well as civil law. Cell Tissue Res (2010) 340:533–540 Author's personal copy DOI 10.1007/s00441-010-0970-z REGULAR ARTICLE The shape modulation of osteoblast–osteocyte transformation and its correlation with the fibrillar organization in secondary osteons A SEM study employing the graded osmic maceration technique Ugo E. Pazzaglia & Terenzio Congiu & Marcella Marchese & Carlo Dell’Orbo Received: 13 December 2009 /Accepted: 29 March 2010 /Published online: 28 April 2010 # Springer-Verlag 2010 Abstract Cortex fractured surface and graded osmic Introduction maceration techniques were used to study the secretory activity of osteoblasts, the transformation of osteoblast to The concept that osteoblasts are cells committed to producing osteocytes, and the structural organization of the matrix bone matrix is well established (Baud 1968). However, other around the cells with scanning electron microscopy (SEM). related aspects like the osteoblast–osteocyte transformation, A specialized membrane differentiation at the base of the cell the formation and extrusion of collagen fibrils, and the was observed with finger-like, flattened processes which control of their spatial orientation remain unanswered formed a diffuse meshwork. These findings suggested that questions and are the subject of conflicting theories (Rouiller this membrane differentiation below the cells had not only et al.
    [Show full text]
  • Laboratory Assignment Skeletal System Overview
    Name: _________________________________________________ Date: __________________________________________________ Laboratory Assignment Skeletal System Overview 1. Match the bone cell with the proper function: a. osteoprogenitor cell b. osteocyte c. osteoblast d. osteoclast ___________ cell formed from the fusion of several stem cells. These cells are involved in the dissolving of bone, helping with the reshaping of the bone when necessary. __________ cell that is considered to be mature; completely surrounded by bony matrix that it helps to maintain. _________ cell that deposits bony matrix, helping to form and repair bone as needed. _________ stem cell that can transform into bones that deposit bone matrix. 2. Identify the following cells seen in this slide of spongy bone: osteoblast, osteoclast, osteocyte 3. the following structures seen in this slide of compact bone (ground): osteon, central canal, concentric lamella, lacuna 5. After viewing both bone types using your microscope and slides, what are the primary structural differences between compact and spongy bone? 6. Identify the following structures that are marked by leader lines in the following illustration of a long bone: canaliculus, central canal, circumferential lamellae, compact bone, lacuna, lamella, nerve, osteocyte, osteon, perforating canal, periosteum, spongy bone. 7. Label the following structures that are marked by leader lines in the following illustration of a long bone: medullary (marrow) cavity, diaphysis, epiphyseal line, endosteum, proximal epiphysis, distal epiphysis, periosteum, blood vessel, compact bone, spongy bone, articular cartilage. (Terms may be used more than once) 8. Match the following bone markings/bony structure with the correct definition: a. crest e. fossa b. process f. fissure c. head g. sulcus d.
    [Show full text]
  • Nomina Histologica Veterinaria
    NOMINA HISTOLOGICA VETERINARIA Submitted by the International Committee on Veterinary Histological Nomenclature (ICVHN) to the World Association of Veterinary Anatomists Published on the website of the World Association of Veterinary Anatomists www.wava-amav.org 2017 CONTENTS Introduction i Principles of term construction in N.H.V. iii Cytologia – Cytology 1 Textus epithelialis – Epithelial tissue 10 Textus connectivus – Connective tissue 13 Sanguis et Lympha – Blood and Lymph 17 Textus muscularis – Muscle tissue 19 Textus nervosus – Nerve tissue 20 Splanchnologia – Viscera 23 Systema digestorium – Digestive system 24 Systema respiratorium – Respiratory system 32 Systema urinarium – Urinary system 35 Organa genitalia masculina – Male genital system 38 Organa genitalia feminina – Female genital system 42 Systema endocrinum – Endocrine system 45 Systema cardiovasculare et lymphaticum [Angiologia] – Cardiovascular and lymphatic system 47 Systema nervosum – Nervous system 52 Receptores sensorii et Organa sensuum – Sensory receptors and Sense organs 58 Integumentum – Integument 64 INTRODUCTION The preparations leading to the publication of the present first edition of the Nomina Histologica Veterinaria has a long history spanning more than 50 years. Under the auspices of the World Association of Veterinary Anatomists (W.A.V.A.), the International Committee on Veterinary Anatomical Nomenclature (I.C.V.A.N.) appointed in Giessen, 1965, a Subcommittee on Histology and Embryology which started a working relation with the Subcommittee on Histology of the former International Anatomical Nomenclature Committee. In Mexico City, 1971, this Subcommittee presented a document entitled Nomina Histologica Veterinaria: A Working Draft as a basis for the continued work of the newly-appointed Subcommittee on Histological Nomenclature. This resulted in the editing of the Nomina Histologica Veterinaria: A Working Draft II (Toulouse, 1974), followed by preparations for publication of a Nomina Histologica Veterinaria.
    [Show full text]
  • Co-Editors-In-Chief: Jane Aubin and David B
    Volume 14S, April 2020 ISSN 2352-1872 Co-Editors-in-Chief: Jane Aubin and David B. Burr Abstracts of the ECTS Congress 2021 48th European Calcifi ed Tissue Society Congress ECTS 2021 Digital Congress 6 – 8 May 2021 followed by the ECTS@Home from 19 – 20 May, 10 – 11 June and on 18 June 2021 Bone Reports 1 (202) Contents lists available at ScienceDirect Bone Reports journal homepage: www.elsevier.com/locate/bonr Volume 1 S, "QSJM 202 Abstracts of the ECTS Congress 202 4th European Calcified Tissue Society Congress ECTS 202 Digital Congress o.BZ GPMMPXFECZUIF&$54!)PNFGSPNo.BZ o+VOFBOEPO+VOF The publication of this Supplement is supported by the European Calcifi ed Tissue Society. Bone Reports 1 (202) Contents lists available at ScienceDirect Bone Reports journal homepage: www.elsevier.com/locate/bonr Volume: 14S, April 2021 Contents page Abstracts of the ECTS Congress 2021 48th European Calcifi ed Tissue Society Congress ECTS 2021 Digital Congress 6 – 8 May 2021 followed by the ECTS@Home from 19 – 20 May, 10 – 11 June and on 18 June 2021 Abstracts of the ECTS Congress 2021 100763 Plenary Oral Presentations 100764 Plenary Oral Presentations 1: Genetics & Bone Plenary Oral Presentations 2: Novel Aspects of Osteoporosis and Treatments Plenary Oral Presentations 3: Progress in Translational Research Concurrent Oral Presentations 100783 Concurrent Oral Presentations 1: Clinical / Public Health: Diseases other than Osteoporosis Concurrent Oral Presentations 1: Basic / Translational: Cancer, Regeneration and Stem Cells Concurrent Oral Presentations
    [Show full text]