pharmaceutics Review Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective Mohammad A. Azad 1,*, Deborah Olawuni 1, Georgia Kimbell 1, Abu Zayed Md Badruddoza 2 , Md. Shahadat Hossain 3 and Tasnim Sultana 4 1 Department of Chemical, Biological and Bioengineering, North Carolina A&T State University, Greensboro, NC 27411, USA;
[email protected] (D.O.);
[email protected] (G.K.) 2 Department of Chemical and Life Sciences Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA;
[email protected] 3 Department of Engineering Technology, Queensborough Community College, City University of New York (CUNY), Bayside, NY 11364, USA;
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[email protected]; Tel.: +1-336-285-3701 Received: 1 January 2020; Accepted: 30 January 2020; Published: 3 February 2020 Abstract: Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry to overcome the traditional manufacturing regime of 'one size fits for all'. Using 3D printing, it is possible to design and develop complex dosage forms that can be suitable for tuning drug release. Polymers are the key materials that are necessary for 3D printing. Among all 3D printing processes, extrusion-based (both fused deposition modeling (FDM) and pressure-assisted microsyringe (PAM)) 3D printing is well researched for pharmaceutical manufacturing. It is important to understand which polymers are suitable for extrusion-based 3D printing of pharmaceuticals and how their properties, as well as the behavior of polymer–active pharmaceutical ingredient (API) combinations, impact the printing process.