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Profile Profile Uses and Administration Adverse Effects, Treatment Mepivacaine Hydrochloride/Pramocaine Hydrochloride 1993 Pregnancy. There is considerable transfer of mepivacaine the symptomatic relief of gastro-oesophageal reflux disease Porphyria. The Drug Database for Acute Porphyria, com­ across the placenta after maternal doses and the ratio of (p. 1807.2). It has also been used as the hydrochloride in piled by the Norwegian Porphyria Centre (NAPOS) and fetal to maternal concentrations' is about 0. 7. Although ointments and suppositories for the relief of pain associated the Porphyria Centre Sweden, classifies oxybuprocaine as neonates have a very limited capacity to metabolise mepi­ with haemorrhoids. not porphyrinogenic when used for surface anaesthesia in vacaine it appears they are able to eliminate the drug.2 ophthalmological procedures; it may be used as a drug of 1. Lurie AO, Weiss JB . Blood concentration of mepivacaine and lidocaine i first choice and no precautions are needed.' �r.��r�t �".� . in mother and baby after epidural anesthesia. Am J Obstet Gynew/ 1910; . ........................................................................... 1. (details are given in Volume B) The Drug Database for Acute Porphyria. Available at: http:lfwww. 106: 850-6. ProprietaryPreparations drugs·porphyria.org (accessed 05/10{1 1) 2. Meffin P, et al. Clearance and metabolism of mepivacaine in the human neonate. Clin Pharmacol Ther 1973; 14: 218-25. Single-ingredient Preparations. India: Tricaioe-MPS; Ital. : Emo­ ren; Jp n: Strocain. Interactions Arg. : Mucaioe; Austral.: �r.�����!�".� . Multi-ingredient Prepara6ons. For interactions associated with local anaesthetics, see . ........................................................................... Mucainet; Austria: Tepilta; Braz. : Droxaine; Canad.: Mucaine; (details are given in Volume B) p. 1979.3. ProprietaryPreparations Fr. : Mutesat; Ger.: Tepilta; Gr.: Oxaine-M; Hong KiJng: Anta­ Single-ingredient Preparations. Arg.: Mepigobbi; Austral.: Car­ caine; Gastrocaine; Mucainet; Oxema Improved; Strocain; � i bocainet; Austria: Mepinaest; Scandicaint; Scandonest; Belg.: India: Acicot-0; Acicral-0; Acinil-0; Acral-0; Alcaine; Alcocid; r.�P.�.r�.� <>,".�........................................................................... Scandicaine; Canad.: Carbocaine; Isocaine; Polocaine; Scandon­ Belief; Bestocid-0; Bluegel-0; Coligon-0; Crasia-0; Daffocid-0; PraprietaryPreparations (details are given io Volume B) est; China: Scandonest ()!JrJ�HI:!B); Cz.: Mepivastesio; Scandon­ Depcid-0; Dicaine; Digiflux-A; Disocain; Erocot-0; Esfate-0; Austria: Benoxinat; Novaio; estt; Denm.: Carbocain; Scandonest; Fin.: Scandonest; Fr. : Car­ Focri-0; Gastromax-0; Graster; Greycid; Jevacain; Kaicid-0; Single-ingredient Preparations. Belg.: Unicaine; Braz. : Oxioest; China: Benoxil Cz.: bocaine; Scandicaine; Ger. : Meaverin; Mecain; Mepi-Welk; Kulent-0; Kulfi; I.acrate-0; Lorcus-0; Maxicaio; Merigel-A; (ffltli::l); Benoxi; Novesint; Fin.: Oftan Obucain; Fr.: Cebesine; Ger.: Mepihexalt; Mepivastesin; Scandicain; Gr.: Mepivakate; Mepi­ Mucaioe; Newcaio; Nubase; OAM; Oshrid; Oxefate-0; Oxy­ Conjuncain-EDO; Novesine; Hung.: Humacain; India: Bend­ vastesin; Optocain; Scandonest; Tevacaine; Hong Kong: Mepi­ cane; Pepticaine; Philipp.: Geltazine; S.Afr.: Mucaine; Singa­ zoot; Israel: Localin; Ital. : Novesioa; Philipp.: Oxybent; Port. : catont; Mepivastesin; Irl.: Scandonest; Israel: Isocaine; Mepica­ pore: Strocain; Spain: Roberfarin; Thai.: Mucainet; Strocain; Anestocil; Rus.: Benoxi (EeuoKcu); Inokain (HHOKOHH); S.Afr. : tont; Mepivastesin; Scandicaine; Ital. : Carbocaina; Turk.: Mucaine. Novesin; Spain: Prescaina; Switz.: Cebesint; Novesin; Thai.: Carboplyioa; Carbosen; Mepi-Mynol; Mepibil; Mepicaio; Mepi­ Novesint; Turk.: Benoxinate; Novesin; Ukr. : Inokain dent; Mepiforan; Mepisolver; Mepivamol; Mepivirgi; Optocain; (Huo!<llHH). Pericaina; Scandonest; Neth.: Scandicainet; Scandonest; Norw.: Oxybuprocaine Hydrochloride Carbocain; Scandonest; Port. : Isogaine; Mepivastesin; Scandi­ Multi-ingredient Preparations. Austral.: Fluresst; Austria: Flure­ rdbsa; Scandonest; Rus.: Mepivastesin (ME!lHBACTE3llH); S. (BANM, r/NNM) kaint; Canad.: Fluress; Fin. : Oftan Flurekaio; Fr.: Collu­ Afr. : Carbocaine; Scandonest; Singapore: Mepivastesin; Spain: Blacbet; Desomedine; Ger.: Thilorbin; Gr.: Collu-Blache; Mex.: Isogaine; Scandinibsa; Scandonest; Swed. : Carbocain; Scandon­ Mentalgina; Port. : Fluotest; Mebocaina; Rus.: Grammidin with est; Switz. : Scandicain; Scandonest; Thai.: Mepicaton; USA: Anesthetic Neo (rpaMMH)IHH c AuecrernKOM Heo); Spain: Anes­ Carbocaine with Neo-Cobefrin; Carbocaine; Isocaine; Polo­ tesico Doble; Fluotest; Swed. : Fluress; Switz.: Collu-Blache; caine; Scandonest. Mebucaine; UAE: B-Cool; Ukr.: Grammidin with Anaesthetic Neo (rpaMMH)IHH C AueCTeTHKoM Heo); USA: Fluorox; Fluratet; Multi-ingredient Prepara6ons. Fluress; Flurox. Used as an adjunct in:. Austria: Estradurin; Belg.: Estradurinet; Denm.: Estradurin; Fin.: Estradurin; Jpn: Amasulin; Bestcall; Pharmacopoeial Preparations BP 2014: Oxybuprocaioe Eye Drops; Pansporin; Takesulint; Norw. : Estradurint; Singapore: Nevra­ USP 36: Benoxinate Hydrochloride Ophthalmic Solution; m.in; Swed.: Estradurin; Switz.: Estradurin; Thai.: Nevramin; Fluorescein Sodium and Benoxinate Hydrochloride Ophthalmic Ukr. : Estradurin (3c1pa.eypHH)t. Solution. Pharmacopoeial Preparations USP 36: Mepivacaine Hydrochloride and Levonordefrin Injection; Mepivacaine Hydrochloride Injection. NOTE. OXB, formerly BNX, is a code approved by the BP 2014 for use on single unit doses of eye drops containing oxybuprocaine hydrochloride where the individual con­ tainer may be too small to bear all the appropriate labelling information. Pharmacopoeias. In Bur. (see p. vii), Jpn, and US. Ph. Eur. 8; (Oxybuprocaine Hydrochloride). A white or almost white, crystalline powder or colourless crystals. It exhibits polymorphism. Very soluble in water; freely soluble Profile in alcohol. A 10% solution in water has a pH of 4.5 to 6.0. Myrtecaine is a local anaesthetic (p. 1976.1) used topically Protect from light. as the base or laurilsulfate in rubefacient preparations for USP 36: (Benoxinate Hydrochloride). White or slightly off­ Pharmacopoeias. In us. white, crystals or crystalline powder, odourless or with a the treatment of muscle and joint pain. Myrtecaine USP 36: (Pramoxine Hydrochloride). A white or almost slight characteristic odour. Soluble 1 in 0.8 of water, 1 in 2.6 laurilsulfate is also used in preparations with antacids for the white crystalline powder; it may have a faint aromatic of alcohol, and 1 in 2.5 of chloroform; insoluble in ether. A symptomatic relief of gastrointestinal disorders. odour. Freely soluble in water and in alcohol; soluble 1 in 35 1% solution in water has a pH of 5.0 to 6.0. of chloroform; very slightly soluble in ether. A I% solution �r.�P.�.��.�!�.".�........................................................................... in water has a pH of about 4.5. Store in airtight containers. PraprielaryPreparations (details are given in Volume B) Uses and Administration Multi-ingredient Preparations. Arg.: Algesal; Austria: Acidrine; Oxybuprocaine, a para-aminobenzoic acid ester, is a local Profile Algesal; Latesyl; Rheugesalt; Traumasal; Chile: Sinacidt; Cz.: anaesthetic with actions and uses similar to those described Pramocaine hydrochloride is a local anaesthetic (p. 1976.1) on p. 1976.1. It is used for surface anaesthesia (p. 1977.3) Algesal; Fr. : Acidrioe; Algesal Suractive; Ger.: Algesalt; Gr.: used for surface anaesthesia. It is used alone or with Algesal Suractive; Hung. : Algesal; Indon.: Acidrine; Algesal and is reported to be less irritant than tetracaine when corticosteroids and other drugs, usually in a concentration Superactive; Ital. : Acidrine; Neth.: Algesal Fortet; Port.: applied to the conjunctiva in therapeutic concentrations. of 1%, in many formulations for the relief of pain and Algesal; Latesil; Spain: Algesal; Turk. : Acidrine; Algesal Surac­ Oxybuprocaine is used as the hydrochloride in a 0.4% itching associated with minor skin conditions and anorectal tive; Venez. : Lemazol. solution in short ophthalmological procedures. One drop disorders. Initial burning or stinging may occur following instilled into the conjunctival sac anaesthetises the surface topical application. It should not be used for the nose or of the eye sufficiently to allow tonometry after 60 seconds eyes. The base has been used similarly. Oxetacaine (BAN, rJNNJ and a further drop after 90 seconds provides adequate anaesthesia for the fitting of contact lenses. Three drops at � i 90-second intervals produces sufficient anaesthesia after 5 .���.��t <>,".�....................................................... .................... minutes for removal of a foreign body from the corneal PraprietaryPreparations (details are given io Volume B) epithelium, or for incision of a Meibomian cyst through the Single-ingredient Preparations. Canad. : Dermoplast Poison Ivy conjunctiva. The sensitivity of the cornea is normal again Treatment; Fr.: Tronothane; Israel: Sarmed; Ital.: Tronotene; S. after about 1 hour. Afr. : Anugesic; Spain: Balsabitt; Denutraxan; Thai.: Primoly; A I% solution of oxybuprocaine hydrochloride is used USA: Campho-Phenique Cold Sore Treatment & Scab Relief; for surface anaesthesia of the ear, nose, and throat. Fleet Pain Relief; Ivy Wash; Pramox; Prax; Proctofoam; Sarna Sensitive Anti-Itch; Tronothane; Vagisil. Arg.: Anusol Duo S; Anusol Duo; Adverse.. ... ......... Effects,. ... .. Tre. ..atment. ............,
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