Mepivacaine Hydrochloride/Pramocaine Hydrochloride 1993
Pregnancy. There is considerable transfer of mepivacaine the symptomatic relief of gastro-oesophageal reflux disease Porphyria. The Drug Database for Acute Porphyria, com across the placenta after maternal doses and the ratio of (p. 1807.2). It has also been used as the hydrochloride in piled by the Norwegian Porphyria Centre (NAPOS) and fetal to maternal concentrations' is about 0. 7. Although ointments and suppositories for the relief of pain associated the Porphyria Centre Sweden, classifies oxybuprocaine as neonates have a very limited capacity to metabolise mepi with haemorrhoids. not porphyrinogenic when used for surface anaesthesia in vacaine it appears they are able to eliminate the drug.2 ophthalmological procedures; it may be used as a drug of 1. Lurie AO, Weiss JB . Blood concentration of mepivacaine and lidocaine i first choice and no precautions are needed.' �r.��r�t �".� . in mother and baby after epidural anesthesia. Am J Obstet Gynew/ 1910; ...... 1. (details are given in Volume B) The Drug Database for Acute Porphyria. Available at: http:lfwww. 106: 850-6. ProprietaryPreparations drugs·porphyria.org (accessed 05/10{1 1) 2. Meffin P, et al. Clearance and metabolism of mepivacaine in the human neonate. Clin Pharmacol Ther 1973; 14: 218-25. Single-ingredient Preparations. India: Tricaioe-MPS; Ital. : Emo ren; Jp n: Strocain. Interactions Arg. : Mucaioe; Austral.: �r.�����!�".� . Multi-ingredient Prepara6ons. For interactions associated with local anaesthetics, see ...... Mucainet; Austria: Tepilta; Braz. : Droxaine; Canad.: Mucaine; (details are given in Volume B) p. 1979.3. ProprietaryPreparations Fr. : Mutesat; Ger.: Tepilta; Gr.: Oxaine-M; Hong KiJng: Anta Single-ingredient Preparations. Arg.: Mepigobbi; Austral.: Car caine; Gastrocaine; Mucainet; Oxema Improved; Strocain; � i bocainet; Austria: Mepinaest; Scandicaint; Scandonest; Belg.: India: Acicot-0; Acicral-0; Acinil-0; Acral-0; Alcaine; Alcocid; r.�P.�.r�.� <>,".�...... Scandicaine; Canad.: Carbocaine; Isocaine; Polocaine; Scandon Belief; Bestocid-0; Bluegel-0; Coligon-0; Crasia-0; Daffocid-0; PraprietaryPreparations (details are given io Volume B) est; China: Scandonest ()!JrJ�HI:!B); Cz.: Mepivastesio; Scandon Depcid-0; Dicaine; Digiflux-A; Disocain; Erocot-0; Esfate-0; Austria: Benoxinat; Novaio; estt; Denm.: Carbocain; Scandonest; Fin.: Scandonest; Fr. : Car Focri-0; Gastromax-0; Graster; Greycid; Jevacain; Kaicid-0; Single-ingredient Preparations. Belg.: Unicaine; Braz. : Oxioest; China: Benoxil Cz.: bocaine; Scandicaine; Ger. : Meaverin; Mecain; Mepi-Welk; Kulent-0; Kulfi; I.acrate-0; Lorcus-0; Maxicaio; Merigel-A; (ffltli::l); Benoxi; Novesint; Fin.: Oftan Obucain; Fr.: Cebesine; Ger.: Mepihexalt; Mepivastesin; Scandicain; Gr.: Mepivakate; Mepi Mucaioe; Newcaio; Nubase; OAM; Oshrid; Oxefate-0; Oxy Conjuncain-EDO; Novesine; Hung.: Humacain; India: Bend vastesin; Optocain; Scandonest; Tevacaine; Hong Kong: Mepi cane; Pepticaine; Philipp.: Geltazine; S.Afr.: Mucaine; Singa zoot; Israel: Localin; Ital. : Novesioa; Philipp.: Oxybent; Port. : catont; Mepivastesin; Irl.: Scandonest; Israel: Isocaine; Mepica pore: Strocain; Spain: Roberfarin; Thai.: Mucainet; Strocain; Anestocil; Rus.: Benoxi (EeuoKcu); Inokain (HHOKOHH); S.Afr. : tont; Mepivastesin; Scandicaine; Ital. : Carbocaina; Turk.: Mucaine. Novesin; Spain: Prescaina; Switz.: Cebesint; Novesin; Thai.: Carboplyioa; Carbosen; Mepi-Mynol; Mepibil; Mepicaio; Mepi Novesint; Turk.: Benoxinate; Novesin; Ukr. : Inokain dent; Mepiforan; Mepisolver; Mepivamol; Mepivirgi; Optocain; (Huo!
NOTE. OXB, formerly BNX, is a code approved by the BP 2014 for use on single unit doses of eye drops containing oxybuprocaine hydrochloride where the individual con tainer may be too small to bear all the appropriate labelling information. Pharmacopoeias. In Bur. (see p. vii), Jpn, and US. Ph. Eur. 8; (Oxybuprocaine Hydrochloride). A white or almost white, crystalline powder or colourless crystals. It exhibits polymorphism. Very soluble in water; freely soluble Profile in alcohol. A 10% solution in water has a pH of 4.5 to 6.0. Myrtecaine is a local anaesthetic (p. 1976.1) used topically Protect from light. as the base or laurilsulfate in rubefacient preparations for USP 36: (Benoxinate Hydrochloride). White or slightly off Pharmacopoeias. In us. white, crystals or crystalline powder, odourless or with a the treatment of muscle and joint pain. Myrtecaine USP 36: (Pramoxine Hydrochloride). A white or almost slight characteristic odour. Soluble 1 in 0.8 of water, 1 in 2.6 laurilsulfate is also used in preparations with antacids for the white crystalline powder; it may have a faint aromatic of alcohol, and 1 in 2.5 of chloroform; insoluble in ether. A symptomatic relief of gastrointestinal disorders. odour. Freely soluble in water and in alcohol; soluble 1 in 35 1% solution in water has a pH of 5.0 to 6.0. of chloroform; very slightly soluble in ether. A I% solution �r.�P.�.��.�!�.".�...... in water has a pH of about 4.5. Store in airtight containers. PraprielaryPreparations (details are given in Volume B) Uses and Administration Multi-ingredient Preparations. Arg.: Algesal; Austria: Acidrine; Oxybuprocaine, a para-aminobenzoic acid ester, is a local Profile Algesal; Latesyl; Rheugesalt; Traumasal; Chile: Sinacidt; Cz.: anaesthetic with actions and uses similar to those described Pramocaine hydrochloride is a local anaesthetic (p. 1976.1) on p. 1976.1. It is used for surface anaesthesia (p. 1977.3) Algesal; Fr. : Acidrioe; Algesal Suractive; Ger.: Algesalt; Gr.: used for surface anaesthesia. It is used alone or with Algesal Suractive; Hung. : Algesal; Indon.: Acidrine; Algesal and is reported to be less irritant than tetracaine when corticosteroids and other drugs, usually in a concentration Superactive; Ital. : Acidrine; Neth.: Algesal Fortet; Port.: applied to the conjunctiva in therapeutic concentrations. of 1%, in many formulations for the relief of pain and Algesal; Latesil; Spain: Algesal; Turk. : Acidrine; Algesal Surac Oxybuprocaine is used as the hydrochloride in a 0.4% itching associated with minor skin conditions and anorectal tive; Venez. : Lemazol. solution in short ophthalmological procedures. One drop disorders. Initial burning or stinging may occur following instilled into the conjunctival sac anaesthetises the surface topical application. It should not be used for the nose or of the eye sufficiently to allow tonometry after 60 seconds eyes. The base has been used similarly. Oxetacaine (BAN, rJNNJ and a further drop after 90 seconds provides adequate anaesthesia for the fitting of contact lenses. Three drops at � i 90-second intervals produces sufficient anaesthesia after 5 .���.��t <>,".�...... minutes for removal of a foreign body from the corneal PraprietaryPreparations (details are given io Volume B) epithelium, or for incision of a Meibomian cyst through the Single-ingredient Preparations. Canad. : Dermoplast Poison Ivy conjunctiva. The sensitivity of the cornea is normal again Treatment; Fr.: Tronothane; Israel: Sarmed; Ital.: Tronotene; S. after about 1 hour. Afr. : Anugesic; Spain: Balsabitt; Denutraxan; Thai.: Primoly; A I% solution of oxybuprocaine hydrochloride is used USA: Campho-Phenique Cold Sore Treatment & Scab Relief; for surface anaesthesia of the ear, nose, and throat. Fleet Pain Relief; Ivy Wash; Pramox; Prax; Proctofoam; Sarna Sensitive Anti-Itch; Tronothane; Vagisil. Arg.: Anusol Duo S; Anusol Duo; Adverse...... Effects,...... Tre. ..atment...... , .and...... Preca...... utions...... Multi-ingredient Preparations...... Anusol-A; Milorixt; Tocorectal; Belg. : Nestosyl; Canad.: Anuge As for Local Anaesthetics in general, p. 1978.1, p. 1979. 1, sic-HC; Anusol Plus; Anuzinc HC Plus; Anuzinc Plus; Aveeno and p. 1979.1, respectively. Anti-Itch; Caladrylt; Gold Bond Anti-Itch; Gold Bond Medi Pharmacopoeias. In Br. and Jp n. cated; Hemorrhoid Ointment; Hemorrhoidal Ointment; BP 2014: (Oxetacaine). A white or almost white powder. Effects on the eyes. Fibrinous iritis and moderate corneal Onguent Hemorrhoidalt; Polysporin Itch Relief; Polysporin lip Practically insoluble in water; freely soluble in methyl swelling occurred in 2 patients after the use of a 0.4% or Treatment; PrameGel; Pramox HC; Proctodan-HC; Proctofoam alcohol; very soluble in chloroform; soluble in ethyl acetate. 1% solution of oxybuprocaine hydrochloride for topical HC; Sama-P; Cht1e: Caladryl Clear; Ir1. : Anugesic-HC; Anuge anaesthesia of the eye for minor surgery.1 The effects may sic-HC; Proctofoam-HC; Israel: Epifoam; Hemoridt; have been due to inadvertent entry of the drug into the Proctofoam-HC; Ital. : Procto!oam-HC; Mex.: Caladryl Clear; Profile anterior chamber of the eye. Soyaloid Apruri; Neth.: Nestosyl; S.Afr.: Anugesict; Turk.: Oxetacaine is an amide anaesthetic (p. 1976.1) that is stated 1. Haddad R. Fibrinous iritis due to oxybuprocaine. Br J Ophthalmol l989; Hipokort Arti; UK: Anugesic-HCt; Anugesic-HC; Proctofoam to have a prolonged action. It is used orally with antacids for 73: 76-7. HC; USA: I+ 1-F; AmLactio APt; Analpram E; Analpram-HC; The symbol t denotes a preparation no longer actively marketed