International Journal of Clinical Medicine, 2014, 5, 966-1005 Published Online August 2014 in SciRes. http://www.scirp.org/journal/ijcm http://dx.doi.org/10.4236/ijcm.2014.516129 The Ethical Implications for Humans in Light of the Poor Predictive Value of Animal Models Ray Greek Americans For Medical Advancement, Goleta, USA Email:
[email protected] Received 11 June 2014; revised 10 July 2014; accepted 9 August 2014 Copyright © 2014 by author and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract The notion that animals could be used as predictive models in science has been influenced by rel- atively recent developments in the fields of complexity science, evolutionary and developmental biology, genetics, and evolutionary biology in general. Combined with empirical evidence, which has led scientists in drug development to acknowledge that a new, nonanimal model is needed, a theory—not a hypothesis—has been formed to explain why animals function well as models for humans at lower levels of organization but are unable to predict outcomes at higher levels of or- ganization. Trans-Species Modeling Theory (TSMT) places the empirical evidence in the context of a scientific theory and thus, from a scientific perspective, the issue of where animals can and can- not be used in science has arguably been settled. Yet, some in various areas of science or science- related fields continue to demand that more evidence be offered before the use of animal models in medical research and testing be abandoned on scientific grounds.