Emtree Terms Changed in May 2019 1

Emtree Terms Added and Changed (May 2019)

This is an overview of new terms added and changes made in the second Emtree release in 2019.

Overall, Emtree has grown by 526 preferred terms (155 drug terms and 371 non-drug terms) compared with the previous version released in January 2019. In total Emtree now counts 82970 preferred terms.

Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept.

The terms added and changed are summarized below and specified in detail on the following pages.

Emtree Terms Added in May 2019

567 new terms (including 41 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version May 2019 (compared to January 2019):

◼ 176 drug terms (terms assigned to the Chemicals and Drugs facet). ◼ 391 non-drug terms (terms not assigned as Chemicals and Drugs).

The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2019 (typically as candidate terms), sometimes for several years, before they were added to Emtree.

Emtree Terms Changed in May 2019

41 terms (21 drug terms and 20 non-drug terms) from Emtree January 2019 have been replaced by 39 different terms in May 2019 (21 drug terms and 18 non-drug terms).

Of these, 32 terms (16 drug terms and 16 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2019; the remaining 7 replacement terms (5 drug terms and 2 non-drug terms) were already present in Emtree.

No drug terms were replaced by a non-drug term, no non-drug term were replaced by a drug term. No preferred terms were deleted.

Changes are presented in alphabetical order of the new terms. Emtree Terms Added in May 2019 2

Drug terms

ABC-type alpha-factor-pheromone transporter dersimelagon ABC-type beta-glucan transporter deruxtecan ABC-type capsular-polysaccharide transporter diclofenac plus paracetamol ABC-type Cd2+ transporter dilpacimab ABC-type dipeptide transporter dm1 (drug) ABC-type fatty-acyl-CoA transporter dm4 ABC-type Fe3+ transporter dostarlimab ABC-type ferric citrate transporter duocarmazine ABC-type ferric enterobactin transporter durlobactam ABC-type ferric hydroxamate transporter eftozanermin alfa ABC-type glycerol 3-phosphate transporter eladocagene exuparvovec ABC-type guanine transporter eluforsen ABC-type heme transporter emtansine ABC-type lipid A-core oligosaccharide transporter encequidar ABC-type lipopolysaccharide transporter ensifentrine ABC-type maltose transporter epinephrine plus mepivacaine ABC-type Mn2+ transporter etokimab ABC-type molybdate transporter exicorilant ABC-type Na+ transporter ferredoxin-NAD+ oxidoreductase (Na+- ABC-type Ni2+ transporter transporting) ABC-type nitrate transporter fosgemcitabine palabenamide ABC-type nonpolar-amino-acid transporter fosifloxuridine nafalbenamide ABC-type oligopeptide transporter foslinanib ABC-type oligosaccharide transporter fosmanogepix ABC-type phosphate transporter futibatinib ABC-type phosphonate transporter galicaftor ABC-type polar-amino-acid transporter gallium 68 plus germanium 68 ABC-type polyamine transporter garetosmab ABC-type protein transporter gentamicin plus hydrocortisone aceponate plus ABC-type quaternary amine transporter miconazole ABC-type sulfate transporter gleptoferron plus toltrazuril ABC-type taurine transporter golexanolone ABC-type teichoic-acid transporter gremubamab ABC-type tungstate transporter H+-exporting diphosphatase ABC-type vitamin B12 transporter hexapneumine anetumab hyaluronidase plus trastuzumab apamistamab i 131 iadademstat ascorbate ferrireductase (transmembrane) idecabtagene vicleucel atoltivimab ilginatinib avexitide indatuximab avian infectious bronchitis virus vaccine lenzumestrocel barzuxetan leriglitazone bermekimab lorvotuzumab betamethasone acetate plus florfenicol plus maftivimab terbinafine masupirdine biclotymol maytansine derivative biotin-dependent malonate decarboxylase menaquinol oxidase (H+-transporting) branebrutinib mertansine caldariellaquinol oxidase (H+-transporting) miricorilant cantuzumab mitochondrial protein-transporting ATPase carboxybiotin decarboxylase mivavotinib chloroplast protein-transporting ATPase murlentamab cobolimab Na+-transporting two-sector ATPase coccidiosis vaccine NADH:ubiquinone reductase (Na+-transporting) coltuximab nanatinostat danicopan neluxicapone Emtree Terms Added in May 2019 3 nerinetide rolinsatamab nimacimab rolinsatamab talirine obexelimab rovafovir etalafenamide odevixibat ruxotemitide olenasufligene relduparvovec samotolisib olinvacimab selatogrel omega interferon seprehvir ontamalimab serdexmethylphenidate orilanolimab setamevetcel osocimab setogepram oxaloacetate decarboxylase (Na+ extruding) sintilimab oxymetazoline plus tetracaine siremadlin P-type Ag+ transporter soticlestat P-type Cu+ transporter spesolimab P-type Cu2+ transporter tabituximab P-type K+ transporter tabituximab barzuxetan P-type Mg2+ transporter tafasitamab P-type Na+ transporter taniborbactam P-type phospholipid transporter telaglenastat P-type Zn2+ transporter temelimab pegbelfermin teserpaturev porcine atrophic rhinitis vaccine tildacerfont porcine circovirus porcine enzootic pneumonia tirbanibulin vaccine toripalimab porcine parvovirosis vaccine translocase pozelimab ubiquinol oxidase (electrogenic, proton-motive prademagene zamikeracel force generating) prolgolimab ubiquinol oxidase (H+-transporting) protein-secreting ATPase umibecestat proton-translocating NAD(P)+ transhydrogenase vafidemstat ravtansine valecobulin repotrectinib vofatamab resamirigene bilparvovec volrubigene ralaparvovec resmetirom zampilimab rocacetrapib Emtree Terms Added in May 2019 4

Non-drug terms brushite stone bulbar conjunctiva calcaneonavicular coalition calcium carbonate urolithiasis A Measurement Tool to Assess Systematic Reviews calcium oxalate dihydrate stone abdominal aortic wall calcium oxalate monohydrate stone Acarapis calcium oxalate urolithiasis Aceria calcium phosphate urolithiasis adactylia calcium stone (cholelithiasis) adult neuronal ceroid lipofuscinosis calcium stone (urolithiasis) Alocasia macrorrhizos canalolithiasis alveolar crest cancer free survival amebic keratitis Candida haemulonis amnesic shellfish poisoning cardiovascular calcification Amorphophallus konjac Caretta Amorphophallus paeoniifolius carotid artery calcification Amorphophallus paeoniifolius var. campanulatus carpal coalition amputation free survival caudal ventrolateral medulla anhydramnios CC50 (cytotoxic concentration) parameters CD50 (cytotoxic dose) anterior vena cava cerebral ischemia reperfusion injury aorta stripping cerebrospinal fluid-to-serum ratio aortic arch aneurysm Chelonia aortic calcification chemical fingerprinting aortic root calcification aortic valve calcification choline deficiency apatite stone chromium deficiency Arbutus chronic pulmonary aspergillosis Arbutus unedo Clinacanthus arginine deficiency Clinacanthus nutans Arum maculatum Codex Alimentarius Arum palaestinum comet parameters ascending aortic aneurysm concanavalin A-induced liver injury Australopithecus conformity (social behavior) avoidant restrictive food intake disorder congenital amputation B-3 cell line (lens epithelium) congenital hereditary endothelial dystrophy B12 deficiency coprolite bacteriotherapy cupulolithiasis band keratopathy cutting stapler behavioral test parameters cystine stone benzo[a]pyrene-resistant cell line cytotoxic dose Bietti crystalline dystrophy dacryolithiasis bioabsorbable mesh data accuracy biochemical disease free survival data completeness biochemical progression free survival data consistency biotin deficiency data paper bladder contractility index data quality bladder intercontraction interval data quality assessment bladder outlet obstruction index data validity bladder strip brevis Blighia sapida descending aortic aneurysm bone hydatidosis diabetic eye disease bone surface density diabetic keratopathy bone volume diabetic ophthalmoplegia bone volume fraction diarrhetic shellfish poisoning brain echinococcosis disability free survival brain-to-serum ratio distant disease free survival breast tomosynthesis system distant progression free survival bromine poisoning distant recurrence free survival broncholithiasis dolichostenomelia Emtree Terms Added in May 2019 5 dose volume histogram Homo denisovan Dracocephalum Homo erectus Dracocephalum kotschyi Homo heidelbergensis Dracocephalum moldavica hot yoga emotional eating humeral component of shoulder prosthesis end-diastolic pressure-volume relationship humeral cup end-systolic pressure-volume relationship humeral stem endothelium-intact aortic ring humeroradial synostosis enterolithiasis hypocupremia EO771 cell line hypoferremia epithelial basement membrane dystrophy hypophalangia erectile tissue (penis) infantile neuronal ceroid lipofuscinosis Eretmochelys infrarenal aortic aneurysm Eriophyidae inner retina experimental Chagas disease internal limiting membrane experimental protozoal infection International Federation of Red Cross and Red experimental Staphylococcus aureus infection Crescent Societies experimental Staphylococcus infection intestinal stasis external limiting membrane intoeing fear of missing out iron refractory iron deficiency anemia fecaloma iyengar yoga filamentary keratitis joint spacer Finnish variant late infantile neuronal ceroid juvenile neuronal ceroid lipofuscinosis lipofuscinosis juxtarenal aortic aneurysm fish poisoning keratoglobus flexible flatfoot keratomalacia food neophobia KID syndrome food refusal Laelapidae food standard Laelaps fornix conjunctiva late infantile neuronal ceroid lipofuscinosis fractional shortening lattice corneal dystrophy Fragaria vesca lattice corneal dystrophy type 1 Fuchs endothelial dystrophy lattice corneal dystrophy type 2 Fukomys left auditory cortex gastric stasis left inguinal lymph node gastrointestinal stasis left pulmonary artery gelatinous drop-like corneal dystrophy deliense genetic fingerprinting lethal time GH1 cell line (pituitary tumor) lipid fingerprinting glenoid baseplate Liponyssoides glenoid component of shoulder prosthesis Liponyssoides sanguineus glenoid liner local disease free survival glenoid sphere local progression free survival glutamine deficiency LT100 granular corneal dystrophy LT50 granular corneal dystrophy type 1 LT90 granular corneal dystrophy type 2 lung ischemia reperfusion injury Haff disease lymphomonocyte hatha yoga M-7 cell line (fibrosarcoma) Health Canada macrodactyly heart calcification Macronyssidae heart echinococcosis macular corneal dystrophy heart left ventricle enddiastolic diameter manganese deficiency heart left ventricle endsystolic diameter manganese poisoning heart valve calcification manganism hepatic inflammatory pseudotumor maximum non-toxic dose hepatic ischemia reperfusion injury Medical Education Research Study Quality hereditary corneal dystrophy Instrument histamine poisoning Medicines and Healthcare products Regulatory HMEC cell line (microvascular endothelium) Agency Emtree Terms Added in May 2019 6 medullary reticular formation Pinellia ternata megalocornea PLA-801C cell line mesenteric vascular bed porcelain aorta metabolic fingerprinting porcelain gallbladder methicillin susceptible Staphylococcus aureus posterior polymorphous corneal dystrophy infection posterior vena cava methionine deficiency Preferred Reporting Items for Systematic Reviews microbial keratitis and Meta-Analyses microcalcification product quality microcornea prostate strip minimum biofilm eradication concentration prostatic calcification mitral valve calcification prostatic lithiasis molecular fingerprinting protein fingerprinting molybdenum cofactor deficiency pseudoainhum molybdenum deficiency puffer fish poisoning muscle dysmorphia pulmolithiasis Nash equilibrium punding neuronal ceroid lipofuscinosis 6 Purtscher like retinopathy neuronal ceroid lipofuscinosis 8 Purtscher's retinopathy neurotoxic shellfish poisoning Quality Assessment of Diagnostic Accuracy Studies neurotrophic keratopathy quality assessment tool no-observed-effect level radioulnar synostosis no-toxic-effect level rapunzel syndrome nonalcoholic steatohepatitis Red Crescent nonproliferative diabetic retinopathy regional failure free survival Notoedres Reis-Bucklers corneal dystrophy oligodactyly renal ischemia reperfusion injury Olive tail moment retinal vascular disease opportunity cost right auditory cortex orbit hydatid cyst right inguinal lymph node Ornithonyssus right pulmonary artery Ornithonyssus bacoti rigid flatfoot Ornithonyssus bursa Schnyder corneal dystrophy Ornithonyssus sylviarum scombroid poisoning orthorexia seafood poisoning out toeing selective intrauterine growth restriction ovarian cortex selenosis ovarian stroma silica stone (urolithiasis) palpebral conjunctiva silica-induced pulmonary fibrosis pancreas hydatid cyst silk gland pancreatolithiasis sinus irrigation pantothenic acid deficiency SK-OV-3/CDDP cell line paralytic shellfish poisoning soft-shelled turtle Paranthropus sole dermatoglyphics pararenal aortic aneurysm Sorbus aucuparia paw thickness spastic flatfoot Penaeus chinensis special situation for pharmacovigilance Penaeus indicus spleen hydatid cyst Penaeus japonicus Standard Gamble Penaeus merguiensis Staphylococcus aureus infection Penaeus semisulcatus struvite stone Penaeus vannamei subchondral bone peptide mass fingerprinting suppurative keratitis percentage of tail DNA suprarenal aortic aneurysm pes planovalgus tail extent moment pes valgus tail intensity pes varus tail length (animal) pharmacovigilance tail length (comet assay) phlyctenular keratoconjunctivitis tail moment photokeratitis talocalcaneal coalition Emtree Terms Added in May 2019 7

Tarsonemidae trichophagia taurine deficiency tryptophan deficiency testotoxicosis Turkish variant late infantile neuronal ceroid therapeutic dose lipofuscinosis (CLN7) Thibierge Weissenbach syndrome twin anemia polycythemia sequence Thiel Behnke corneal dystrophy twin oligohydramnios polyhydramnios sequence thoracic aortic wall twin reversed arterial perfusion sequence Tilia cordata Typhonium time trade-off method unexpected outcome of drug treatment timeliness United Nations Food and Agricultural Organization timeliness (data) uterine lavage Tinospora crispa vertical talus tissue oximeter vitamin B deficiency tissue spectrometer voided volume tomosynthesis system voiding efficiency total shoulder prosthesis Willingness To Pay trabecular bone pattern factor World Bank trabecular number xanthine stone trabecular separation xerocytosis trabecular thickness yoga nidra transplant free survival treatment free survival

Emtree Terms Added in May 2019 8

Drug terms New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term apamistamab i 131 iomab B avexitide exendin 9 bermekimab xilonix bulaquine* 8 [4 (3 acetyl 4,5 dihydro 2 furylamino) 1 methylbutylamino] 6 methoxyquinoline danicopan ach 0144471 eluforsen qr 010 gallium 68 plus germanium 68 germanium 68 plus gallium 68 garetosmab regn2477 givosiran* aln as1 iadademstat ory 1001 ilginatinib 2 [1 (4 fluorophenyl)ethylamino] 4 (1 methyl 1h pyrazol 4 yl) 6 (2 pyrazinylamino)pyridine imlifidase* hmed ides leriglitazone hydroxypioglitazone mesmulogene ancovacivec* tg 4010 mivavotinib tak 659 obexelimab xmab5871 ontamalimab pf 547659 Pelargonium sidoides extract* umckaloabo seprehvir HSV 1716 setogepram 3 pentylbenzeneacetic acid volrubigene ralaparvovec at342

Emtree Terms Added in May 2019 9

Non-drug terms New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term aorta stripping aortic strip B-3 cell line (lens epithelium) B-3 cell line B12 deficiency cyanocobalamin deficiency behavioral test parameters behavioral test parameter benzo[a]pyrene-resistant cell line benzo[a]pyrene resistant cell line calcium oxalate urolithiasis calcium oxalate stone CC50 (cytotoxic concentration) CC50 EO771 cell line E0771 cell line hereditary corneal dystrophy congenital cornea dystrophy HMEC cell line (microvascular endothelium) HMEC cell line (microvascular endothelial) M-7 cell line (fibrosarcoma) M-7 cell line pancreatolithiasis pancreas stone Penaeus* Farfantepenaeus Penaeus* Fenneropenaeus Penaeus* Litopenaeus Penaeus chinensis Fenneropenaeus chinensis Penaeus vannamei Litopenaeus vannamei retinoblastoma cell line* RB cell line (retinoblastoma) SK-OV-3/CDDP cell line SK-OV-3/DDP cell line therapeutic dose curative dose