JOURNAL OF VOLUME 48 NUMBER 3 DECEMBER 1983 Edward M. Scolnick, Editor in Chief (1987) Merck Sharp & Dolime Research Laboraitories Wes.t Point, Pa. David T. Denhardt, Editor (1987) Robert M. Krug, Editor (1987) University of Western Ontario Sloan-Kettering Institute London, Ontario, Canada New York, N.Y. Bernard N. Fields, Editor (1988) Michael B. A. Oldstone, Editor (1988) Harvard University, Medical School Sc ripps Clinic & Research Fouindation Boston, Mass. La Jolla, Calif. Harold S. Ginsberg, Editor (1984) Robert A. Weisberg, Editor (1988) Coluimbia University National Institlute of Child Health and Human Development New York, N.Y. Bethesda, Md.

EDITORIAL BOARD David Baltimore (1984) Alice S. Huang (1984) Harriet Robinson (1985) Amiya K. Banerjee (1985) Tony Hunter (1983) William S. Robinson (1983) Andrew Becker (1985) Masayori Inouye (1985) Bernard Roizman (1985) Tamar Ben-Porat (1984) Robert Kamen (1985) Roland R. Rueckert (1985) Kenneth I. Berns (1985) Thomas J. Kelly, Jr. (1985) Norman P. Salzman (1984) David Botstein (1985) George Khoury (1984) Joseph Sambrook (1985) Dennis T. Brown (1984) Elliott Kieff (1984) Priscilla A. Schaffer (1984) Ahmad I. Bukhari (1984) Jonathan A. King (1984) Sondra Schlesinger (1983) Barrie J. Carter (1984) Daniel Kolakofsky (1983) June R. Scott (1983) Purnell Choppin (1983) Robert Lamb (1985) Bart Sefton (1985) John M. Coffin (1983) Robert A. Lazzarini (1984) Phillip A. Sharp (1985) Geoffrey M. Cooper (1984) Myron Levine (1985) Thomas E. Shenk (1984) Walter Doerfler (1983) Douglas R. Lowy (1983) Charles J. Sherr (1984) (1984) Robert Martin (1984) Saul J. Silverstein (1985) Elvera Ehrenfeld (1983) George Miller (1984) Lee D. Simon (1984) Robert N. Eisenman (1985) Lois K. Miller (1985) Ann Skalka (1985) Suzanne U. Emerson (1983) Robert C. Miller (1983) Patricia G. Spear (1984) S. Jane Flint (1984) Peter Model (1983) Mark F. Stinski (1983) Yasuhiro Furuichi (1985) (1983) F. William Studier (1984) Costa Georgopolous (1983) Nancy G. Nossal (1984) Lawrence S. Sturman (1985) Larry M. Gold (1985) J. Thomas Parsons (1983) Jesse Summers (1985) Peter Gruss (1985) Ulf G. Petterson (1983) William Summers (1985) Hidesaburo Hanafusa (1983) Lennart Philipson (1984) John M. Taylor (1984) William S. Hayward (1984) Lewis I. Pizer (1984) Howard M. Temin (1985) John J. Holland (1984) Craig R. Pringle (1983) George F. Vande Woude (1983) Ian H. Holmes (1983) Fred Rapp (1984) Edward K. Wagner (1983) Robert W. Honess (1983) Dan S. Ray (1983) Eckard Wimmer (1985) Nancy Hopkins (1983) M. E. Reichmann (1985) Charles Hamish Young (1983) Peter M. Howley (1984) Gordon M. Ringold (1984)

Helen R. Whiteley, Chairman, Publications Boacrd Walter G. Peter III, Direc tor, Publications Linda M. Illig, Managing Editor, Jouirnals Paula R. Ellison, Production Editor

The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 1 St., NW. Washington, DC 20006, is devoted to the dissemination of fundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including . biophysics, , immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Office. The Jollrnlal is issued monthly, four volumes per year. The nonmember subscription price is $225 per year; single copies are $20. The member subscription price is $37 (foreign, $44 [surface ratel) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs. disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Office, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues 'missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Jouirnal of Virology, ASM, 1913 I St., NW, Washington. DC 20006. Made in the U.S.A. Copyright © 1983, American Society for Microbiology. (*fdli(f4P(JtkJ. L1'.JI' ( I'1I.t All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition. however, that the copier pay the stated per-copy fee through the Copyright Clearance Center. 21 Congress St., Salem. MA 01970. for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index

Aasted, Bent, 573 Hamagishi, Yasutaro, 709 Ricci, William, 667 Andersen, Klaus B., 765 Hanafusa, Hidesaburo, 744 Ronda, Concepci6n, 721 Appella, Ettore, 709 Henry, Berch, II, 580 Roussel, Martine F., 770 Hood, Rachel, 580 Roy, Polly, 627 Hudewentz, J., 731 Ruddle, Frank H., 770 Banks, L., 591 Hughes, Stephen H., 667 Baric, Ralph S., 633 Hunter, Tony, 752 Barker, Peter E., 770 Bishop, J. Michael, 565 Ito, Yoshiaki, 709 Sadowski, Paul D., 647 Bloom, Marshall E., 573 Schlesinger, Sondra, 676 Boone, Lawrence R., 779 Schwarz, E., 731 Bornkamm, G. W., 731 Jolicoeur, Paul, 685 Scolnick, Edward M., 752 Brackmann, Karl H., 604 Segawa, Kaoru, 709 Brewer, Gregory J., 774 Sherr, Charles J., 770 Buekens, Pierre, 697 Kahlon, Jasbir, 627 Sironi, Gianpiero, 616 Klempnauer, Karl-Heinz, 565 Smith, Julie K., 654 Koh, Chong-kun, 779 Sorge, Joe, 667 Cogniaux-LeClerc, Jacqueline, 697 Koprowski, Hilary, 660 Sprecher-Goldberger, Suzanne, Cohen, G., 591 Kramer, Tammo A., 604 697 Cooper, Jonathan A., 752 Stohlman, Stephen A., 633 Costa, R. H., 591 Sugiyama, Kazuo, 627 Cywinski, Anita, 654 Lai, Michael M. C., 633 Symington, Janey S., 604 Laux, G., 731 Lee, Donald, 647 Dalianis, Tina, 709 Levis, Robin, 676 Taylor, John M., 654 DesGroseillers, Luc, 685 L6pez, Rubens, 721 Tennant, Raymond W., 779 Draper, K. G., 591 Lucher, Lynne A., 604 Thiry, Lise, 697

Eisenberg, R., 591 Mayer, Leonard W., 573 Wagner, E. K., 591 Weaver, Robert F., 641 Weiss, Barbara, 676 Foster, David A., 744 Olislager, Roland, 697 Wiktor, Tadeusz J., 660 Freese, U. K., 731 Ou, Chin-yih, 779 Willingham, Mark, 709 Fuchs, L. Yolanda, 641 Ozanne, Brad, 752 Woods, Michael S., 641 Wunner, William H., 660 Garcia, Ernesto, 721 Pagano, Joseph S., 580 Garon, Claude F., 573 Powell, K. L., 591 Yang, Czau-Siung, 580 Ghisotti, Daniela, 616 Yang, Wen K., 779 G6mez, Antonio, 721 Goto, Ronald M., 774 Raab-Traub, Nancy, 580 Green, Maurice, 604 Reagan, Kevin J., 660 Zangrossi, Sandro, 616 ACKNOWLEDGMENT The following have served as invited special reviewers for the Journal during 1983, and their help is greatly appreciated. Stu Aaronson Diane Cuppels Berg Hampar Samuel Dales Daniel Hardy Rafi Ahmed Vittorio Defendi Janet Hartley Charles A. Alford, Jr. Mel DePamphilis William Haseltine James Alwine Ravi Dhar John Hassell Robert Anderson Jules L. Dienstag Stanley Hattman Steven Anderson Dan Dimaio Anne M. Haywood Ralph Arlinghaus George Dimayorca Ari Helenius Richard Armentrout Dino Dina Roger Hendrix Richard Axel Martin E. Dorf Roger Hewitt Howard L. Bachrach R. Gordon Douglas Lawrence Hightower John Bader Walter Dowdle Maurice R. Hilleman George Baer Gordon Dreesman Shalom Z. Hirschman Corrado Baglioni Gideon Dreyfus Monto Ho L. Andrew Ball Peter Duesberg John J. Holland Marcel Baluda Walter Eckhart F. Blaine Hollinger Mariano Barbacid John Elder John A. Holowczak J. Richard Baringer Ron Ellis Marshall Horwitz Samuel Baron Francis A. Ennis Sally Huber Renato Baserga Lynne Enquist Joe Hughes Claudio Basilico Marcia J. Ensinger Jerry Hurwitz Robert Bassin Lois B. Epstein Richard Hyman Karen Beeman H. Gunti Erdl James N. Ihle Thomas Benjamin Raymond Erikson Mark Israel Arnold Berk Max Essex Yoshiaki Ito Anna Bialkowska Mary Kolb Estes Gilbert Jay David Bishop Anthony S. Fauci Richard T. Johnson Michael Bishop Gerald Fink Wolfgang Joklik Klaus Bister James B. Flanegan David Kabat Donald Blair Erwin Fleissner Albert Kapikian Barry Bloom Stephen C. Foster Robert S. Kauffman Marshall E. Bloom Michael M. Frank Vicki E. Kelley David Boettinger Robert Friedman D. C. Kelly Dani Bolognesi Ted Friedman Eli Keshet Michael Botchan Mark Furth Edwin D. Kilbourne Pierre Bourgaux Robert Gallo Saul Kit Joan Brugge Anthony Garro David Knipe Michael Buchmeier E. Peter Geidushek Christine Kozak Steven Burakoff Walter Gerhard D. H. Kruger Howard Bussey John L. Gerin Edward Kuff Janet Butel Anne A. Gershon Michael Lai Bruce Calnek Mary Jane Gething Ronald A. Laskey Robert B. Carroll Raymond Gilden Paul Lebowitz Eric B. Carstens W. Paul Glezon Phillip Leder Sherwood Casjens Laurie Glimcher Stanley S. Lefkowitz Esther Chang Yosha Gluzman Robert I. Lehrer Robert Chanock Nigel Godson John Lenard Lan Bo Chen Steve Goff Peter Lengyel Craig Cohen Angus Graham Arnold J. Levine Gary H. Cohen Frank L. Graham Michael Levine Charles Cole Harry B. Greenberg Art Levinson Philip Coleman Mark I. Greene Michael Liebowitz Richard Colonno Terry Grodziger Frank Lilly Richard W. Compans Charles F. Grose Tomas Lindahl Jon Condra Ashley T. Haase David Linemeyer Louis Z. Cooper Mary Haffey Maxine Linial Richard J. Courtney Gordon Hager David Livingston Richard L. Crowell Jules Hallum Harvey Lodish Clyde Crumpacker Scott B. Halstead Carlos Lopez J. Lucas-Lenard David Porter Bruce W. Stillman George Mackie Poteete Steven E. Straus Tak Mak Kenneth L. Powell James Strauss Kirstine Mann Carol Prives Jack L. Strominger Eleftheria Maratos-Flier Robert Purcell Max D. Summers Dante Marciani Paul G. Quie Stanley Tahara Philip Marcus Charles Radding Kenneth Takemoto Stuart Marcus Cedric Raine Igor Tamm Malcolm Martin R. Frank Ramig Peter J. Tattersall Philip E. McAllister Saraiya Rasheed Peter Tegtmeyer William McClements William Rawls Gretchen Temeles Donald McCorquodale Alan Rein Irwin Tessman Dale McFarlin Jack S. Remington Mary J. R. Tevethia Travis C. McGuire, Jr. Roberta Reuben Satvir Tevethia Kenneth McIntosh Markus Rhoades Robert Thach Roger McMacken Solon Rhode III Dennis Trent Donald N. Medearis, Jr. Mark Riemen Stephen Udem Pamela Mellon William S. Robinson Bernard van der Jeist Joseph Melnick George Rohrmann James Van Etten Thomas C. Merigan, Jr. John Rose Harold Varmus Barry 1. Milavetz Martin Rosenberg Leland F. Velicer Thomas P. Monath Naomi Rosenberg Inder Verma John Moorhead Lanny J. Rosenwasser Jan T. Vilcek Gisela Mosig Barry Rouse Peter Vogt Richard Moxon Martine Roussel Robert Wagner Brian Murphy Wallace Rowe Duard L. Walker Robert Murray Frank Ruddle Jack Wands A. J. Nahmias Kathleen Rundell Joseph Weber Opendra Narayan Sandra Ruscetti Michael Weber Dan Nathans Philip K. Russell Steven L. Wechsler Neal Nathenson Martin Ruta Robert Weinberg Paul E. Neiman Paul Sadowski Howard Weiner Abner L. Notkins Charles E. Samuel Leslie P. Weiner John F. Obijeski Andreas S. Scheid David Weinstein Paul O'Donnell R. Walter Schlesinger Robin Weiss Lloyd Old Stuart F. Schlossman Susan Weiss Allen Oliff Loren Schultz Sherman Weissman Steve Oroszlan Robert S. Schwartz Raymond M. Welsh, Jr. June E. Osborn Arup Sen Reed Wickner Michael N. Oxman Ganes Sen Jim Williams Joseph Pagano John L. Sever Owen Witte Peter Palese David Shafritz Linda Wolff Enzo Paoletti Arlene Sharpe H. A. Wood Wade Parks Aaron J. Shatkin William Wunner Robert H. Parrott Robert E. Shope Richard Wyatt James Pennington Steven L. Shore Keith Yamamoto Janice Pero Maxine Singer Robert H. Yolken Sidney Pestka N. K. Sinha Faith Yoshimura Bruce A. Phillips Larry Snyder Howard Young Paula Pitha Dennis Stacey Julius Youngner Bernard Poiesz Jack Stevens Stuart Yuspa Robert Pollack William E. Stewart 11 Hans J. Zweerink INDEX TO DATE OF ISSUE

Month Date of Issue Pages October 20 September 1983 1-334 November 21 October 1983 335-564 December 17 November 1983 565-785

U.S. rstlS-ric. STATEMENT OF OWNERSHIP MANAGEMENT AND CIRCULATION ROIFieJ by 39 US C 3683)

TITlE OF PugLICATION 1B. PUBLICATION NO. 2 DATE OF FILING

Journal of Virology 30 September 1983 3FROENeO ISSUE 3 OO SUSPBIHD3 NULSBCITO ANNUALI Y PRICE Mootthly 12 $37 mbr, 0225 nonmbr "COMPLETE MAILING ADDRESS OF KNOWN OFFICE OF PUBLICATION (S010e,. CY,y. CFuFy. SOFFOFFd ZFPCodOF INOFpriFtrtJ

1913 I Street, N.W., Washington, D.C. 20006 5 COMPLETE MAILING ADDRESS OF THE HEADOUARTERS OF GENERAL BUSINESS OFFICES OF THE PUBLISHER INtFopSFFO)

1913 1 Street, N.W., Washington, D.C. 20006

FUIL NAMESAND COMPLETE MAILING ADDRESS OF PUBLISHER, EDITOR. AND MANAGING EDITOR IOFOIFFO F8USTNOrb, bDOFk UBS ER {sar- .nd C-mpl-eMa-l Add,,.s)

American Society for Microbiology, 1913 1 Street, N.W., Washington, D.C. 20006 EDITOR (NF-F FdCo-pFMF011Add-Fs Director of Publications Walter G. Peter III, 1913 I Street, N.W., Washington, D.C. 20006 MANAGING EDITOR CN--OFend C-pl-r MFIIFF. Addr,-)F

Walter G. Peter III, same as above 7 OWNER bvevprno se nddrsmtb, Jt,td..d.homudrhnmwnedrJ.osokiittt t1f-wnd Fo FF0F0FFo ,0 F 0- hWldIf ZDI ntor-oF. o k FFFFFov FFFdbyeF-F p -rh.0t.dd-10138h8oth0FndFi.dOid..lovFF nrOF bFl.hO d b, ef CnofiF FF,.IRFFFFIFOFOFFFFed eddr rt 0u- b .,ld m -uFb0omFpl,Id

r _ XX ~~~~FULL NAME |COMPLETE MAILING ADDRESS nerican Sogiety 1FFTioooblology 11913 I Street, N.W., WasTiingTont .C 00U

8 KNOWN BONDHOLOERS, MORTGAGEES, AND OTHER SECURITY HOLDERS OWNING OR HOLDING PERCENT OR MORE OF TOTAL AMOUNT OF BONDS, MORTGAGES OR OTHER SECURITIES /1f-So n FULL NAME COMPLETE MAILING AODRESS None

FOR COMPLETION BY NONPROFIT ORGANIZATIONSAUTHORIZEDO F MAIL AT SPECIAL RATES 1S00i.F.23 12DMM.oyI |hups,f---io, nd noProfil wt.u of 1h,, .ryg-4.0. *nd th. ...-pt wt.tu f.r F.d- incme.o sUp-p-r Ch-kt -n.1 <11 {~~~~~~~~~~~~~2) HAS NOT CHANGED DURING HAS CHANGED DURING IFTrnfFd. PFbliFhO.1FFFFFb-FFFFxFlnFoIF PRECEDINGP 12 MONTHS L PRECEDING 12 MONTHSFhFnN w,h 10 AVERAGE NO COPIES EACH ACTUAL NO. COPIES OF SINGLE 10 EXTENT AND NATURE OF CIRCULATION ISSUE DURING PRECEDING ISSUE PUBLISHED NEAREST TO 12 MONTHS FILING DATE A TOTAL NO COPIES(Nf PF,- R,I 7614 7838 8 PAID CIRCULATION (Member) S0.,F h,oFuF d.FIFF F FFIFF FF0d .F.FItulF 2836 3101

?R2FM, S cOFFF io,Fb,F (Nonmember) 1449 1657 C TOTAL PAID CIRCULATION FSFm0f 10BI Fd 108721 4285 4758 D FREE DISTRIBUTION BY MAIL, CARRIER OR OTHER MEANS SAMPLES, COMPLIMENTARY, AND OTHER FREE COPIES 100 100 |LEFTOTAL DISTRIBUTION FSF0 ofCo-d DI 4385 4858 F COPIE! NOT DISTRIBUTEO off lOlFF0o, -FFFF-FI0d, Poiltd It., P--FOg 3229 2980

2 | Retur Iro N.-r Agen- G TOTALFOFFI.eSu-FF,ol FF.01E. Fl r.ndFF0 22-FFFFFFFFIFI0FFFOFFFF0FOFwh-ld evu.l -e p--snun i.wn. A)Fl 761464737838 i 1 N) SIGNAT0F E AND TITLE OF EDITOR, PUBLISHER. BUSINESS MANAGER, OR OWNER certify that the statements made by I ,./4' me above are correct and complete L7FI>0 Aj( s PS Form (See inlstruction ont revwrse) J.', 19i82 3526 AUTHOR INDEX VOLUME 48

Aasted, Bent, 573 Cords, Carl E., 561 Hardy, Medora M., 31 Aboud, Mordechai, 120 Costa, R. H., 591 Hayashi, Marie N., 186 Ahola, Harri, 370 Costanzo, Franco, 325 Hayashi, Masaki, 186 Akusjarvi, G., 127 Costanzo, Maria, 555 Hayward, S. Diane, 135 Anders, David G., 197, 206 Cox, Nancy J., 52 Henderson, Louis E., 314 Andersen, Klaus B., 765 Crawford, Lionel V., 262 Henry, Berch, II, 580 Anderson, Carl W., 31 Cywinski, Anita, 654 Hoganson, Neal, 492 Appella, Ettore, 709 Holmes, Ian H., 330 Ariga, Hiroyoshi, 481 Hood, Rachel, 580 Arnold, Georg, 157 Dalianis, Tina, 709 Horzinek, Marian C., 249 Atkinson, Paul H., 335 Dall'Olio, Fabio, 325 Huberman, Joel A., 304 Dasgupta, Asim, 429 Hudewentz, J., 731 DeLamarter, John, 451 Hughes, Stephen H., 667 Bachi, Thomas, 239 DePamphilis, Melvin L., 281 Huleihel, Mahmoud, 120 Banks, L., 591 DesGroseillers, Luc, 685 Hunter, Tony, 752 Baric, Ralph S., 633 Dietrich, Walter, 377 Barker, Peter E., 770 Dorsett, Dale L., 218 Barnett, Jim W., 384 Draper, K. G., 591 Ikura, Koji, 460 Barrett, Kathleen J., 157 Dunn, John J., 31 Iorio, Ronald M., 440 Bates, Robert C., 10 Dyall-Smith, Michael L., 330 Israel, Mark A., 40 Bellamy, A. Richard, 335 Ito, Yoshiaki, 709 Betz, Joan L., 460 Bishop, J. Michael, 565 Eisenberg, R., 591 Bister, Klaus, 61 Eisenberg, Roselyn J., 521 Jablonska, Stefania, 340 Blanck, George, 492 Emini, Emilio A., 547 Jansen, Hans W., 61 Bleumink, Nancy, 249, 262 Ensinger, Marcia J., 419 Jeang, Kuan-Teh, 135 Blinkova, Aleksandra, 157 Eppstein, Deborah A., 384 Jentoft, J., 361 Blissard, Gary W., 74 Evans, Mary Jo, 304 Jolicoeur, Paul, 685 Bloom, Marshall E., 573 Boccara, Martine, 102 Bodemer, Walter, 377 Favre, Michel, 340 Kahlon, Jasbir, 627 Boeye, Albert, 309 Feitelson, Mark A., 534 Kantharidis, Phillip, 330 Boone, Lawrence R., 110, 779 Fleckenstein, Bernhard, 377 Kendal, Alan P., 52 Bornkamm, G. W., 731 Fleissner, Erwin, 102 Keshet, Ilana, 218, 229 Both, Gerald W., 52, 335 Fleming, Jo-Ann G. W., 74 Klempnauer, Karl-Heinz, 565 Brackmann, Karl H., 604 Folk, William R., 472 Klessig, Daniel F., 31 Bratt, Michael A., 440 Foster, David A., 744 Knight, Susan S., 534 Brewer, Gregory J., 774 Freese, U. K., 731 Knust, Elisabeth, 377 Brugge, Joan S., 352 Fuchs, L. Yolanda, 641 Koh, Chong K., 110 Brzustowicz, Linda, 555 Koh, Chong-kun, 779 Buekens, Pierre, 697 Koprowski, Hilary, 660 Burke, Julian F., 304 Ganem, Don, 1 Kozak, Christine A., 300 Garcfa, Ernesto, 721 Kramer, Tammo A., 604 Garon, Claude F., 40, 573 Kremsdorf, Dina, 340 Campadelli-Fiume, Gabriella, 325 Gerhard, Walter, 239 Kupper, Hans, 451 Campbell, Bruce A., 561 Ghisotti, Daniela, 616 Carlson, Karin, 18 Ghosh, Prabhat K., 503 Carter, Barrie J., 79 Gibson, Marylou G., 396 Lai, Michael M. C., 633 Chambraud, B., 127 Gilardi, P., 127 Larson, Ruby, 320 Chan, Hardy W., 384 G6mez, Antonio, 721 Laub, Orgad, 271 Chen, Suzie, 492 Goto, Ronald M., 774 Laux, G., 731 Cheung, Andrew, 451 Graessmann, A., 296 Lavie, Vered, 229 Chowdhury, Kamal, 40 Graessmann, M., 2% Lederman, Muriel, 10 Cogniaux-LeClerc, Jacqueline, 697 Grass, David S., 492 Lee, Donald, 647 Cohen, G., 591 Green, Maurice, 604 Leis, J., 361 Cohen, Gary H., 521 Grinnell, Brian W., 88 Le Moullec, J. M., 127 Collett, Marc S., 320 Levis, Robin, 676 Collins, Lisa, 542 Hamagishi, Yasutaro, 709 Lewis, Anita J., 352 Consigli, Richard A., 197, 206 Hanafusa, Hidesaburo, 744 Lipsich, Leah A., 352 Cooper, Jonathan A., 752 Hannett, Nancy, 555 Lomax, Nancy B., 410 i ii AUTHOR INDEX J. VIROL. L6pez, Rubens, 721 Powell, K. L., 591 Sugiyama, Kazuo, 627 Lucher, Lynne A., 604 Purchio, A. F., 320 Summers, Max D., 74 Swyryd, Elizabeth A., 249, 262 Symington, Janey S., 604 Magarian, Claudette, 102 Raab-Traub, Nancy, 580 Manley, James L., 492 Rall, Leslie B., 271 Marcus-Sekura, Carol J., 79 Reagan, Kevin J., 660 Tack, Lois C., 281 Margolskee, Robert F., 405 Ricci, William, 667 Taylor, Austin L., 149 Marion, Patricia L., 534 Roberson, Laurence E., 110 Taylor, John M., 654 Matthews, James T., 521 Robinson, William S., 534 Tennant, Raymond W., 110, 779 Mayer, Leonard W., 573 Romantschuk, Martin L., 180 Thiry, Lise, 697 McBeth, Dani L., 149 Ronda, Concepci6n, 721 Thomas, Adri A. M., 309 McKinney, Martin D., 551 Rothwell, Victoria M., 472 Truett, Martha, 271 Mirault, Marc-Edouard, 249 Roussel, Martine F., 770 Tsubota, Yoriaki, 304 Mirenda, Carol, 542 Rovinsky, Michael, 419 Moreno-Lopez, Jorge, 370 Roy, Polly, 627 Morrow, Casey D., 429 Ruddle, Frank H., 770 Valenzuela, Pablo, 271 Muller, Uwe R., 170, 180, 186 Rutter, William J., 271 van der Zeijst, Bernard A. M., Myer, Fred E., 110 249, 262 Varmus, Harold E., 1 Sadler, John R., 460 Vinson, S. Bradleigh, 74 Nasri, M., 127 Sadowski, Paul D., 647 Voorma, Harry O., 309 Nathans, Daniel, 405 Scannavini, Maurizia, 325 Norkin, Leonard C., 503 Schlesinger, Sondra, 676 Wagner, E. K., 591 Noyes, Barbara E., 249 Schwarz, E., 731 Wagner, Robert R., 88 Scolnick, Edward M., 752 Waqar, M. Anwar, 304 Seeger, Christoph, 1 Weaver, Robert F., 641 Oliff, Allen, 542 Segawa, Kaoru, 709 Wechsler, James A., 551 Olislager, Roland, 697 Serafini-Cessi, Franca, 325 Weiser, Barbara, 1 Oroszlan, Stephen, 314 Shaul, Yosef, 271 Weiss, Barbara, 676 Orth, Gerard, 340 Sherr, Charles J., 770 Weiss, Stephen, 451 Oshiro, Lyndon S., 534 Siegman, Linda J., 335 Weissman, Sherman M., 503 Ostapchuk, Philomena, 547 Sironi, Gianpiero, 616 Westphal, H., 2% Osterhaus, Albert D. M. E., 249 Sleigh, Merilyn J., 52 Wiberg, John S., 18 Ou, Chin-Yih, 110 Smith, Julie K., 654 Wiktor, Tadeusz Ou, Chin-yih, 779 Smythers, Gary, 314 J., 660 Ozanne, Brad, 752 Sorge, Joe, 667 Willingham, Mark, 709 Souyri, Michele, 102 Wimmer, Eckard, 547 Sowder, Raymond, 314 Winocour, Ernest, 218, 229 Pagano, Joseph S., 580 Spear, Patricia G., 396 Woods, Michael S., 641 Parker, Barbara, 249 Sprecher-Goldberger, Suzanne, Wunner, William H., 660 Patschinsky, Tilo, 61 697 Pero, Janice, 555 Stalhandske, P., 127 Yang, Czau-Siung, 580 Perricaudet, M., 127 Standring, David N., 271 Yang, D. M., 110 Pettersson, U., 127 Stark, George R., 249, 262 Yang, Wen K., 110, 779 Pettersson, Ulf, 370 Stavnezer, Edward, 102 Yewdell, Jonathan W., 239 Piatak, Michael, 503 Stenlund, Arne, 370 Yin, Fay H., 410 Pizer, Lewis I., 460 Stohlman, Stephen A., 633 Plummer, M. Joan, 304 Stout, Ernest R., 10 Pollack, Robert E., 492 Sugano, Sumio, 481 Zangrossi, Sandro, 616 SUBJECT INDEX VOLUME 48

Adeno-associated virus 4utographa californica chromatin-like structure of DNA, 79 nuclear polyhedrosis virus Adenovirus novel RNA polymerase, 641 type 2 S. frugiperda cells, 641 DNA-binding protein gene, 31 viral transcription, 641 independent, spontaneous mutants, 31 Avian myeloblastosis virus major late transcription unit, 127 c-myb transduction monkey cells, 31 cellular gene, 565 polyadenylic acid addition sites, 127 points of recombination, 565 simian virus 40 hybrid, 31 Avian oncovirus Aleutian disease virus MH2 antigen expression molecular cloning of proviral DNA, 61 recombinant plasmid, 573 structural analysis of viral RNA and protein, 61 molecular cloning, 573 Avian retrovirus recombinant plasmid DNA discontinuities, 654 antigen expression, 573 ppl2 protein Antibody interaction with viral RNA, 361 anti-idiotypic Avian sarcoma virus rabies virus glycoprotein, 660 monoclonal antibodies antipeptide transforming proteins, 352 human adenovirus 2 ElB-19K tumor antigen, 604 transforming proteins human adenovirus 2 ElB-53K tumor antigen, 604 monoclonal antibodies, 352 monoclonal anti-hemagglutinin, 239 avian sarcoma virus transforming proteins, 352 Baboon endogenous virus baboon endogenous virus cell receptors, 697 cell receptors group B coxsackieviruses, 561 monoclonal antibodies, 697 influenza virus A/PR/834, 239 monoclonal antibodies inhibition of virus attachment, 561 cell receptors, 697 irreversible antigenic alterations, 239 Newcastle disease virus, 440 Cp-l neutralizing protease-sensitive transfection of S. pneumoniae, rabies virus glycoprotein, 660 721 nonapeptide, 709 G4 poliovirus DNA secondary structure modifications, 170 bivalent attachment, 547 enzymatic construction and selection of mutants, conformational alteration and neutralization, 547 170 genome-linked protein VPg, 429 gene expression, 180 NH2 terminus, 429 J-F intercistronic region, 170, 180, 186 synthetic nonapeptide, 429 mRNA stability, 186 polyomavirus, 709 mutations, 180 Antigen lambda Aleutian disease virus dnaB protein, 551 recombinant plasmid, 573 P protein, 551 middle T replication, 551 nonapeptide, 709 RNA polymerase interaction, 551 polyomavirus, 709 Mu super T E. coli K-12 DNA polymerase I, 149 simian virus 40, 492 growth, 149 transformed mouse cells, 492 P4 surface a gene, 157 duck hepatitis B virus, 534 RNA polymerase, 157 hepatitis B virus, 271 P2-x major polypeptide, 534 interference by E. coli, 616 synthesis in mammalian cells, 271 4X174 T gene expression, 180 early replicating DNA intermediates, 281 J-F intercistronic region, 180, 186 simian virus 40 chromosome complexes, 281 mRNA stability, 186 tumor mutations, 180 antipeptide antibodies, 604 simian virus 40 recombinant genomes, 229 human adenovirus 2 EIB-19K, 604 PM2 human adenovirus 2 ElB-53K, 604 gram-negative host, 774

iii iv SUBJECT INDEX J. VIROL. phosphatidylethanolamine accessibility, 774 Duck hepatitis B virus SPO1 surface antigen gene 27, 555 major polypeptide, 534 T4 cytosine, 18 in vivo cleavage, 18 Electron microscopy T7 microinjected simian virus 40 direct physical assay, 647 spliced cRNA, 296 in vitro DNA recombination, 647 Epidermodysplasia verruciformis BHK cells human papillomavirus 8, 340 lymphocytic choriomeningitis virus human papillomavirus 10, 340 persistent infection, 262 human papillomavirus 3a, 340 RNAs, 262 human papillomavirus 12, 340 viral proteins, 262 Epstein-Barr virus Sindbis virus abortive cycle defective-interfering RNAs, 678 transcription of two distant clusters of partially persistent infection, 678 homologous small repeats, 731 virus RNAs, 678 DNA molecule organization Bluetongue virus mRNA transcript, 135 neutralization Notl repeat units, 135 molecular basis, 627 P3HR-I deletion junction, 135 Bovine cells template, 135 bovine viral diarrhea virus 12-O-tetradecanoylphorbol-13-acetate, 135 virus-specific RNA, 320 lytic cycle Bovine parvovirus transcription of two distant clusters of partially proteins, 10 homologous small repeats, 731 Bovine viral diarrhea virus nasopharyngeal carcinoma bovine cells transcription, 580 virus-specific RNA, 320 transcription nasopharyngeal carcinoma, 580 Escherichia coli bacteriophage P2-A interference, 616 Campoletis sonorensis virus K-12 parasitized host Heliothis virescens, 74 bacteriophage Mu growth, 149 Carcinoma DNA polymerase I, 149 nasopharyngeal Eucaryotic cells Epstein-Barr virus transcription, 580 herpes simplex virus Cellular transcription class I defective DNA, 384 inhibition European Elk papillomavirus vesicular stomatitis virus, 88 characterization of genome, 370 Chickens induction of tumors in animals, 370 Fujinami sarcoma virus transformation in vitro, 370 tumors, 744 Exonuclease Rous sarcoma virus alkaline tumors, 744 herpes simplex virus type 1, 591 tumors Fujinami sarcoma virus, 744 Rous sarcoma virus, 744 Feline sarcoma virus Chromatin Snyder-Theilen adeno-associated virus DNA structure, 79 epidermal growth factor receptor metabolism, 752 Chromosome human A431 cells, 752 human 5 protein kinase activity, 752 assignment of c-fms locus, 770 Foot-and-mouth disease virus molecular cloning of c-fms locus, 770 serotypes Chromosomes major antigenic determinants, 451 replicating simian virus 40 Friend mink cell focus-inducing virus a-like DNA polymerase, 304 molecular cloning in vitro DNA synthesis, 304 normal cells, 542 simian virus 40 T-antigen complexes, 281 transformed cells, 542 Coxsackievirus normal cells group B molecular cloning, 542 inhibition of attachment, 561 transformed cells monoclonal antibodies, 561 molecular cloning, 542 Cytosine Fujinami sarcoma virus bacteriophage T4 fps gene in vivo cleavage, 18 free of gag gene sequences, 744 VOL. 48, 1983 SUBJECT INDEX v induction of tumors in chickens, 744 Herpesvirus saimiri transformation of cells in culture, 744 transformed lymphoid tumor cell line virus-specific transcription, 377 Human A431 cells Harvey murine sarcoma virus Glycosylation epidermal growth factor receptor metabolism, 752 simian rotavirus SA 1I gene segment 10 protein kinase activity, 752 noncleaved signal peptide, 335 Kirsten murine sarcoma virus Ground squirrel hepatitis virus epidermal growth factor receptor metabolism, 752 livers protein kinase activity, 752 asymmetrical heterogeneous forms, I Snyder-Theilen feline sarcoma virus closed circular viral DNA, I epidermal growth factor receptor metabolism, 752 protein kinase activity, 752 Human adenovirus 2 Hamster tumor cell line antipeptide antibodies, 604 integrated polyomavirus DNA COOH terminus, 604 structural analysis, 40 EIB-19K tumor antigen, 604 Heliothis virescens EIB-53K tumor antigen, 604 parasitized host NH2 terminus, 604 C. sonorensis virus, 74 Human papillomavirus Hemagglutinin 8 influenza virus A/PR/834 biochemical characterization, 340 acid activation of hemolysis, 239 epidermodysplasia verruciformis, 340 mediation of hemolysis, 239 molecular cloning, 340 monoclonal antibodies, 239 10 influenza virus H3 biochemical characterization, 340 antigenic drift, 52 epidermodysplasia verruciformis, 340 multiple evolutionary pathways, 52 molecular cloning, 340 sequential amino acid changes, 52 3a monoclonal antibodies biochemical characterization, 340 influenza virus A/PR/834, 239 epidermodysplasia verruciformis, 340 irreversible antigenic alterations, 239 molecular cloning, 340 Hemolysis 12 influenza virus A/PR/834 biochemical characterization, 340 acid activation, 239 epidermodysplasia verruciformis, 340 mediation, 239 molecular cloning, 340 Hepatitis B virus Human rhinovirus surface antigen host range mutants expression of coding region, 271 altered nonstructural proteins, 410 expression of entire gene, 271 synthesis in mammalian cells, 271 Herpes simplex virus Influenza virus class I defective DNA A/PR/834 eucaryotic cells, 384 acid activation of hemolysis, 239 molecular cloning vehicle, 384 irreversible antigenic alterations, 239 eucaryotic cells mediation of hemolysis, 239 class I defective DNA, 384 monoclonal anti-hemagglutinin antibodies, 239 insertion mutants H3 hemagglutinin duplication of glycoprotein D gene, 396 antigenic drift, 52 two forms of glycoprotein D, 396 multiple evolutionary pathways, 52 type I sequential amino acid changes, 52 alkaline exonuclease, 591 capsid protein, 591 retrovirus glycoprotein D synthesis and processing in vitro, inhibition of DNA supercoiling, 120 521 glycoproteins, 325 high-resolution characterization of transcripts, Leupeptin 591 mouse fibroblasts N-acetylgalactosaminyltransferase activity, 325 inhibition of retrovirus infection, 765 0-glycosylation, 325 retrovirus short unique region, 460 inhibition of infection in mouse fibroblasts, 765 SmaI fragment, 460 Lymphocytic choriomeningitis virus transcribed RNAs, 460 BHK cells type 2 persistent infection, 262 glycoprotein D synthesis and processing in vitro, RNAs, 262 521 viral proteins, 262 vi SUBJECT INDEX J. VIROL. persistent infection protein kinase activity, 752 BHK cells, 262 Kirsten intracellular agent, 249 epidermal growth factor receptor metabolism, 752 standard cell lines, 249 human A431 cells, 752 standard cell lines protein kinase activity, 752 persistent infection, 249 Lymphoid tumor cell line H. saimiri-transformed virus-specific transcription, 377 N-Acetylgalactosaminyltransferase herpes simplex virus type I glycoproteins, 325 Newcastle disease virus Mammalian cells epitopes hepatitis B surface antigen monoclonal antibodies, 440 synthesis, 271 HN glycoprotein Mink cell focus-forming virus monoclonal antibodies, 440 mouse chromosomal locus monoclonal antibodies genetic mapping, 300 four epitopes, 440 replication HN glycoprotein, 440 mouse chromosomal locus, 300 Nuclear polyhedrosis virus Monkey cells A. californica adenovirus type 2-simian virus 40 hybrid novel RNA polymerase, 641 adenovirus type 2 DNA-binding protein gene, 31 S. frugiperda cells, 641 independent, spontaneous mutants, 31 viral transcription, 641 Mouse fibroblasts leupeptin inhibition of retrovirus infection, 765 0-glycosylation retrovirus herpes simplex virus type I glycoproteins, 325 inhibition of infection by leupeptin, 765 Mouse hepatitis virus replicative-intermediate RNA Phosphatidylethanolamine leader RNA sequences, 633 accessibility in bacteriophage PM2 and gram-nega- nascent chains, 633 tive host, 774 Mouse lymphoid cells Phosphorylation leukemic polyomavirus major capsid protein VPI, 206 retrovirus env transcript, 102 Plasmid normal recombinant retrovirus env transcript, 102 Aleutian disease virus antigens, 573 Mouse mammary tumor virus Poliovirus env gene products antibody proteolytic cleavage sites, 314 bivalent attachment, 547 terminal amino acid sequences, 314 conformational alteration and neutralization, 547 Murine leukemia virus genome-linked protein VPg, 429 BALB/c genome-linked protein VPg physical mapping of Fv-1 tropism host range antibody, 429 determinant, 685 NH2 terminus, 429 BALB/c B-tropic synthetic nonapeptide, 429 Fv-1 host range property, 779 in vitro RNA replication nucleotide sequences of gag-pol regions, 779 inhibition, 429 BALB/c N-tropic native VPg, 429 Fv-1 host range property, 779 NH2 terminus nucleotide sequences of gag-pol regions, 779 genome-linked protein VPg, 429 B-tropic specific proteins genome, 110 synthesis and cleavage, 309 in vitro restriction endonuclease fragment ex- synthetic nonapeptide change, 110 genome-linked protein VPg, 429 molecular clone, 110 Polyadenylic acid reversal of Fv-1 host range, 110 adenovirus type 2 major late transcription unit N-tropic addition sites, 127 genome, 110 Polyomavirus in vitro restriction endonuclease fragment ex- A2 change, 110 comparison with polyomavirus Crawford small- molecular clone, 110 plaque variant, 472 reversal of Fv-1 host range, 110 antibodies Murine sarcoma virus cross-reaction with cellular protein(s), 709 Harvey middle T antigen, 709 epidermal growth factor receptor metabolism, 752 nonapeptide, 709 human A431 cells, 752 cellular protein(s) VOL. 48, 1983 SUBJECT INDEX vii antibodies, 709 mouse fibroblasts middle T antigen, 709 inhibition of infection by leupeptin, 765 Crawford small-plaque variant Rotavirus comparison with polyomavirus A2, 472 SAII comparison with polyomavirus strain 3, 472 gene coding assignments, 330 DNA sequence, 472 gene products, 330 integrated DNA segments 7, 8, and 9, 330 hamster tumor cell line, 40 Rous sarcoma virus structural analysis, 40 115-nucleotide direct repeat major structural protein VPI cis-acting RNA packaging locus, 667 carboxy-terminal region, 197 Schmidt-Ruppin-A chemical cleavage, 197 induction of tumors in chickens, 744 cleavage products, 197 src gene, 744 major phosphorylation region, 206 transformation of cells in culture, 744 nonphosphorylated species, 206 phosphorylated species, 206 receptor moiety, 197 middle T antigen Serine antibodies, 709 simian virus 40 VPI mutant cross-reaction with cellular protein(s), 709 codons, 405 nonapeptide, 709 Simian rotavirus nonapeptide SAII antibodies, 709 coding assignment, 335 middle T antigen, 709 gene segment 10, 335 strain 3 glycosylation sites, 335 comparison with polyomavirus Crawford small- noncleaved signal peptide, 335 plaque variant, 472 nucleotide sequence, 335 Protease Simian virus 40 bacteriophage Cp-l DNA adenovirus type 2 hybrid transfection of S. pneumoniae, 721 DNA-binding protein gene, 31 S. pneumoniae independent, spontaneous mutants, 31 transfection by bacteriophage Cp-l DNA, 721 monkey cells, 31 Protein kinase bacteriophage OX174 recombinant genomes Harvey murine sarcoma virus single cells, 229 human A431 cells, 752 structure, 229 human A431 cells chromosome-T-antigen complexes Harvey murine sarcoma virus, 752 early replicating DNA intermediates, 281 Kirsten murine sarcoma virus, 752 functional origin of replication Snyder-Theilen feline sarcoma virus, 752 super T antigen generation, 492 Kirsten murine sarcoma virus transformed mouse cells, 492 human A431 cells, 752 in vitro DNA replication Snyder-Theilen feline sarcoma virus initiation, 481 human A431 cells, 752 late mRNA forms 5' end sequences, 503 microinjected Rabies virus electron microscopy, 296 anti-idiotypic antibodies spliced cRNA, 2% glycoprotein, 660 nonhomologous recombination pathway glycoprotein quantitation, 218 anti-idiotypic antibodies, 660 replicating chromosomes neutralizing antibodies, 660 a-like DNA polymerase, 304 neutralizing antibodies in vitro DNA synthesis, 304 glycoprotein, 660 super T antigen generation Restriction endonuclease functional origin of replication, 492 fragment exchange in vitro transformed mouse cells, 492 murine leukemia virus genomes, 110 transformed mouse cells reversal of Fv-l host range, 110 functional origin of replication, 492 Retrovirus super T antigen generation, 492 DNA supercoiling VPI mutant inhibition in interferon-treated cells, 120 missense mutations, 405 env transcript serine codons, 405 leukemic mouse lymphoid cells, 102 suppression, 405 normal mouse lymphoid cells, 102 viral agnogene, 405 interferon-treated cells Sindbis virus inhibition of DNA supercoiling, 120 BHK cells leupeptin defective-interfering RNAs, 678 inhibition of infection in mouse fibroblasts, 765 persistent infection, 678 viii SUBJECT INDEX J. VIROL.. virus RNAs, 678 Tumors persistent infection chickens BHK cells, 678 Fujinami sarcoma virus, 744 defective-interfering RNAs, 678 Rous sarcoma virus, 744 virus RNAs, 678 European Elk papillomavirus, 370 Spodoptera frugiperda cells Fujinami sarcoma virus A. californica nuclear polyhedrosis virus chickens, 744 novel RNA polymerase, 641 Rous sarcoma virus viral transcription, 641 chickens, 744 Streptococcus pneumoniae bacteriophage Cp-l DNA protease-sensitive transfection, 721 virus protease-sensitive transfection WR bacteriophage Cp-l DNA, 721 correlation of genetic and physical maps, 419 Supercoiling marker rescue, 419 interferon-treated cells temperature-sensitive mutations, 419 inhibition, 120 Vesicular stomatitis virus retrovirus DNA serotype Indiana inhibition, 120 inhibition of cellular transcription, 88 viral leader RNA, 88 serotype New Jersey 12-O-Tetradecanoylphorbol- 13-acetate inhibition of cellular transcription, 88 Epstein-Barr virus viral leader RNA, 88 mRNA transcript, 135 Viral leader RNA Transformed mouse cells vesicular stomatitis virus simian virus 40 inhibition of cellular transcription, 88 functional origin of replication, 492 serotype Indiana, 88 super T antigen generation, 492 serotype New Jersey, 88