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JOURNAL of VIROLOGY VOLUME 48 NUMBER 3 DECEMBER 1983 Edward M

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JOURNAL of VIROLOGY VOLUME 48 NUMBER 3 DECEMBER 1983 Edward M JOURNAL OF VIROLOGY VOLUME 48 NUMBER 3 DECEMBER 1983 Edward M. Scolnick, Editor in Chief (1987) Merck Sharp & Dolime Research Laboraitories Wes.t Point, Pa. David T. Denhardt, Editor (1987) Robert M. Krug, Editor (1987) University of Western Ontario Sloan-Kettering Institute London, Ontario, Canada New York, N.Y. Bernard N. Fields, Editor (1988) Michael B. A. Oldstone, Editor (1988) Harvard University, Medical School Sc ripps Clinic & Research Fouindation Boston, Mass. La Jolla, Calif. Harold S. Ginsberg, Editor (1984) Robert A. Weisberg, Editor (1988) Coluimbia University National Institlute of Child Health and Human Development New York, N.Y. Bethesda, Md. EDITORIAL BOARD David Baltimore (1984) Alice S. Huang (1984) Harriet Robinson (1985) Amiya K. Banerjee (1985) Tony Hunter (1983) William S. Robinson (1983) Andrew Becker (1985) Masayori Inouye (1985) Bernard Roizman (1985) Tamar Ben-Porat (1984) Robert Kamen (1985) Roland R. Rueckert (1985) Kenneth I. Berns (1985) Thomas J. Kelly, Jr. (1985) Norman P. Salzman (1984) David Botstein (1985) George Khoury (1984) Joseph Sambrook (1985) Dennis T. Brown (1984) Elliott Kieff (1984) Priscilla A. Schaffer (1984) Ahmad I. Bukhari (1984) Jonathan A. King (1984) Sondra Schlesinger (1983) Barrie J. Carter (1984) Daniel Kolakofsky (1983) June R. Scott (1983) Purnell Choppin (1983) Robert Lamb (1985) Bart Sefton (1985) John M. Coffin (1983) Robert A. Lazzarini (1984) Phillip A. Sharp (1985) Geoffrey M. Cooper (1984) Myron Levine (1985) Thomas E. Shenk (1984) Walter Doerfler (1983) Douglas R. Lowy (1983) Charles J. Sherr (1984) Harrison Echols (1984) Robert Martin (1984) Saul J. Silverstein (1985) Elvera Ehrenfeld (1983) George Miller (1984) Lee D. Simon (1984) Robert N. Eisenman (1985) Lois K. Miller (1985) Ann Skalka (1985) Suzanne U. Emerson (1983) Robert C. Miller (1983) Patricia G. Spear (1984) S. Jane Flint (1984) Peter Model (1983) Mark F. Stinski (1983) Yasuhiro Furuichi (1985) Bernard Moss (1983) F. William Studier (1984) Costa Georgopolous (1983) Nancy G. Nossal (1984) Lawrence S. Sturman (1985) Larry M. Gold (1985) J. Thomas Parsons (1983) Jesse Summers (1985) Peter Gruss (1985) Ulf G. Petterson (1983) William Summers (1985) Hidesaburo Hanafusa (1983) Lennart Philipson (1984) John M. Taylor (1984) William S. Hayward (1984) Lewis I. Pizer (1984) Howard M. Temin (1985) John J. Holland (1984) Craig R. Pringle (1983) George F. Vande Woude (1983) Ian H. Holmes (1983) Fred Rapp (1984) Edward K. Wagner (1983) Robert W. Honess (1983) Dan S. Ray (1983) Eckard Wimmer (1985) Nancy Hopkins (1983) M. E. Reichmann (1985) Charles Hamish Young (1983) Peter M. Howley (1984) Gordon M. Ringold (1984) Helen R. Whiteley, Chairman, Publications Boacrd Walter G. Peter III, Direc tor, Publications Linda M. Illig, Managing Editor, Jouirnals Paula R. Ellison, Production Editor The Journal of Virology (ISSN 0022-538X), a publication of the American Society for Microbiology, 1913 1 St., NW. Washington, DC 20006, is devoted to the dissemination of fundamental knowledge concerning viruses of bacteria, plants, and animals. Investigators are invited to submit reports of original research in all areas of basic virology, including biochemistry. biophysics, genetics, immunology, morphology, physiology, and pathogenesis and immunity. Instructions to authors are published in the January issue each year; reprints are available from the editors and the Publications Office. The Jollrnlal is issued monthly, four volumes per year. The nonmember subscription price is $225 per year; single copies are $20. The member subscription price is $37 (foreign, $44 [surface ratel) per year; single copies are $7.00. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late proofs. disposition of submitted manuscripts, and general editorial matters should be directed to the ASM Publications Office, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680). Claims for missing issues from residents of the United States, Canada, and Mexico must be submitted within 3 months after publication of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing because of failure to report an address change or for issues 'missing from files" will not be allowed. Second-class postage paid at Washington, DC 20006, and at additional mailing offices. POSTMASTER: Send address changes to Jouirnal of Virology, ASM, 1913 I St., NW, Washington. DC 20006. Made in the U.S.A. Copyright © 1983, American Society for Microbiology. (*fdli(f4P(JtkJ. L1'.JI' ( I'1I.t All Rights Reserved. The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be made for personal use or for personal use of specific clients. This consent is given on the condition. however, that the copier pay the stated per-copy fee through the Copyright Clearance Center. 21 Congress St., Salem. MA 01970. for copying beyond that permitted by Sections 107 and 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for advertising or promotional purposes, for creating new collective works, or for resale. Author Index Aasted, Bent, 573 Hamagishi, Yasutaro, 709 Ricci, William, 667 Andersen, Klaus B., 765 Hanafusa, Hidesaburo, 744 Ronda, Concepci6n, 721 Appella, Ettore, 709 Henry, Berch, II, 580 Roussel, Martine F., 770 Hood, Rachel, 580 Roy, Polly, 627 Hudewentz, J., 731 Ruddle, Frank H., 770 Banks, L., 591 Hughes, Stephen H., 667 Baric, Ralph S., 633 Hunter, Tony, 752 Barker, Peter E., 770 Bishop, J. Michael, 565 Ito, Yoshiaki, 709 Sadowski, Paul D., 647 Bloom, Marshall E., 573 Schlesinger, Sondra, 676 Boone, Lawrence R., 779 Schwarz, E., 731 Bornkamm, G. W., 731 Jolicoeur, Paul, 685 Scolnick, Edward M., 752 Brackmann, Karl H., 604 Segawa, Kaoru, 709 Brewer, Gregory J., 774 Sherr, Charles J., 770 Buekens, Pierre, 697 Kahlon, Jasbir, 627 Sironi, Gianpiero, 616 Klempnauer, Karl-Heinz, 565 Smith, Julie K., 654 Koh, Chong-kun, 779 Sorge, Joe, 667 Cogniaux-LeClerc, Jacqueline, 697 Koprowski, Hilary, 660 Sprecher-Goldberger, Suzanne, Cohen, G., 591 Kramer, Tammo A., 604 697 Cooper, Jonathan A., 752 Stohlman, Stephen A., 633 Costa, R. H., 591 Sugiyama, Kazuo, 627 Cywinski, Anita, 654 Lai, Michael M. C., 633 Symington, Janey S., 604 Laux, G., 731 Lee, Donald, 647 Dalianis, Tina, 709 Levis, Robin, 676 Taylor, John M., 654 DesGroseillers, Luc, 685 L6pez, Rubens, 721 Tennant, Raymond W., 779 Draper, K. G., 591 Lucher, Lynne A., 604 Thiry, Lise, 697 Eisenberg, R., 591 Mayer, Leonard W., 573 Wagner, E. K., 591 Weaver, Robert F., 641 Weiss, Barbara, 676 Foster, David A., 744 Olislager, Roland, 697 Wiktor, Tadeusz J., 660 Freese, U. K., 731 Ou, Chin-yih, 779 Willingham, Mark, 709 Fuchs, L. Yolanda, 641 Ozanne, Brad, 752 Woods, Michael S., 641 Wunner, William H., 660 Garcia, Ernesto, 721 Pagano, Joseph S., 580 Garon, Claude F., 573 Powell, K. L., 591 Yang, Czau-Siung, 580 Ghisotti, Daniela, 616 Yang, Wen K., 779 G6mez, Antonio, 721 Goto, Ronald M., 774 Raab-Traub, Nancy, 580 Green, Maurice, 604 Reagan, Kevin J., 660 Zangrossi, Sandro, 616 ACKNOWLEDGMENT The following have served as invited special reviewers for the Journal during 1983, and their help is greatly appreciated. Stu Aaronson Diane Cuppels Berg Hampar Sankar Adhya Samuel Dales Daniel Hardy Rafi Ahmed Vittorio Defendi Janet Hartley Charles A. Alford, Jr. Mel DePamphilis William Haseltine James Alwine Ravi Dhar John Hassell Robert Anderson Jules L. Dienstag Stanley Hattman Steven Anderson Dan Dimaio Anne M. Haywood Ralph Arlinghaus George Dimayorca Ari Helenius Richard Armentrout Dino Dina Roger Hendrix Richard Axel Martin E. Dorf Roger Hewitt Howard L. Bachrach R. Gordon Douglas Lawrence Hightower John Bader Walter Dowdle Maurice R. Hilleman George Baer Gordon Dreesman Shalom Z. Hirschman Corrado Baglioni Gideon Dreyfus Monto Ho L. Andrew Ball Peter Duesberg John J. Holland Marcel Baluda Walter Eckhart F. Blaine Hollinger Mariano Barbacid John Elder John A. Holowczak J. Richard Baringer Ron Ellis Marshall Horwitz Samuel Baron Francis A. Ennis Sally Huber Renato Baserga Lynne Enquist Joe Hughes Claudio Basilico Marcia J. Ensinger Jerry Hurwitz Robert Bassin Lois B. Epstein Richard Hyman Karen Beeman H. Gunti Erdl James N. Ihle Thomas Benjamin Raymond Erikson Mark Israel Arnold Berk Max Essex Yoshiaki Ito Anna Bialkowska Mary Kolb Estes Gilbert Jay David Bishop Anthony S. Fauci Richard T. Johnson Michael Bishop Gerald Fink Wolfgang Joklik Klaus Bister James B. Flanegan David Kabat Donald Blair Erwin Fleissner Albert Kapikian Barry Bloom Stephen C. Foster Robert S. Kauffman Marshall E. Bloom Michael M. Frank Vicki E. Kelley David Boettinger Robert Friedman D. C. Kelly Dani Bolognesi Ted Friedman Eli Keshet Michael Botchan Mark Furth Edwin D. Kilbourne Pierre Bourgaux Robert Gallo Saul Kit Joan Brugge Anthony Garro David Knipe Michael Buchmeier E. Peter Geidushek Christine Kozak Steven Burakoff Walter Gerhard D. H. Kruger Howard Bussey John L. Gerin Edward Kuff Janet Butel Anne A. Gershon Michael Lai Bruce Calnek Mary Jane Gething Ronald A. Laskey Robert B. Carroll Raymond Gilden Paul Lebowitz Eric B. Carstens W. Paul Glezon Phillip Leder Sherwood Casjens Laurie Glimcher Stanley S. Lefkowitz Esther Chang Yosha Gluzman Robert I. Lehrer Robert Chanock Nigel Godson John Lenard Lan Bo Chen Steve Goff Peter Lengyel Craig Cohen Angus Graham Arnold J. Levine Gary H. Cohen Frank L. Graham Michael Levine Charles Cole Harry B. Greenberg Art Levinson Philip Coleman Mark I. Greene Michael Liebowitz Richard Colonno Terry Grodziger Frank Lilly Richard W. Compans Charles F. Grose Tomas Lindahl Jon Condra Ashley T. Haase David Linemeyer Louis Z. Cooper Mary Haffey Maxine Linial Richard J. Courtney Gordon Hager David Livingston Richard L. Crowell Jules Hallum Harvey Lodish Clyde Crumpacker Scott B. Halstead Carlos Lopez J. Lucas-Lenard David Porter Bruce W. Stillman George Mackie Poteete Steven E. Straus Tak Mak Kenneth L. Powell James Strauss Kirstine Mann Carol Prives Jack L.
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