Anti-KCNAB1-Antibody

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TECHNICAL DATA SHEET Cat No: Kab04478 Product Particulars: anti-KCNAB1-antibody Pack Size: 100μg Pack Size: Pack Size: 100μg Purify: Immunogen affinity purified Host: Rabbit Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Ԩ for 24 months (Avoid repeated freeze / thaw cycles.) Background (Function): Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels formed by KCNA1 and KCNA4 (PubMed:17156368). Accelerates the closure of heteromeric channels formed by KCNA2, KCNA5 and KCNA6 (By similarity). Isoform KvB1.2 has no effect on KCNA1, KCNA2 or KCNB1 (PubMed:7890032, PubMed:7890764). Enhances KCNB1 and KCNB2 channel activity (By similarity). Binds NADPH; this is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Has NADPH-dependent aldoketoreductase activity (By similarity). Oxidation of the bound NADPH strongly decreases N-type inactivation of potassium channel activity (By similarity). Immunogen: potassium voltage-gated channel, shaker-related subfamily, beta member 1 Synonyms: KCNA1B Calculated MW: Uniprot ID: Q14722 Specificity: Human, Mouse ,Rat Tested Application: ELISA,WB,IHC,IF Recommended Dilution: Gene ID: 7881 Gene Location: Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE" OUR KINESISDX COMMITMENT : GUARANTEED QUALITY WITH EXPERT TECHNICAL SUPPORT .

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