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Rabbit Anti-KCNV1/FITC Conjugated antibody

SL16920R-FITC

Product Name: Anti-KCNV1/FITC Chinese Name: FITC标记的电压门控钾通道亚基Kv8.1抗体 KCNV1; KCNV1_HUMAN; Neuronal potassium channel alpha subunit HNKA; Potassium voltage gated channel subfamily V member 1; Potassium voltage-gated Alias: channel subfamily V member 1; Voltage gated potassium channel subunit Kv8.1; Voltage-gated potassium channel subunit Kv8.1 Organism Species: Rabbit Clonality: Polyclonal React Species: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep, ICC=1:50-200IF=1:50-200 Applications: not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. Molecular weight: 56kDa Form: Lyophilized or Liquid Concentration: 1mg/ml immunogen: KLH conjugated synthetic peptide derived from human KCNT1 Lsotype: IgG Purification: affinitywww.sunlongbiotech.com purified by Protein A Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year Storage: when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage- gated ion channels from both functional and structural standpoints. Their diverse Product Detail: functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]

Function: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

Subcellular Location: Cell membrane. Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.

Tissue Specificity: Detected in brain.

Post-translational modifications: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity.

Similarity: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.

Database links:

Entrez Gene: 27012 Human

Entrez Gene: 505732 Cow

Entrez Gene: 67498 Mouse Entrezwww.sunlongbiotech.com Gene: 60326 Rat Omim: 608164 Human

SwissProt: Q0P583 Cow

SwissProt: Q6PIU1 Human

SwissProt: Q8BZN2 Mouse

SwissProt: P97557 Rat

Unigene: 13285 Human Unigene: 300079 Mouse

Unigene: 42920 Rat

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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