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Page 1 of 288 Diabetes

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Downregulation of acyl-carnitine by miRNAs

132 and 212 amplifies -stimulated insulin

Mufaddal S. Soni1, Mary E. Rabaglia1, Sushant Bhatnagar1, Jin Shang2, Olga Ilkayeva3,

Randall Mynatt4, YunPing Zhou2, Eric E. Schadt6, Nancy A.Thornberry2, Deborah M. Muoio5,

Mark P. Keller1 and Alan D. Attie1

From the 1Department of , University of Wisconsin, Madison, Wisconsin;

2Department of Metabolic DisordersDiabetes, Merck Research Laboratories, Rahway, New

Jersey; 3Sarah W. Stedman Nutrition and Center, Duke Institute of Molecular

Physiology, 5Departments of Medicine and Pharmacology and Cancer Biology, Durham, North

Carolina. 4Pennington Biomedical Research Center, Louisiana State University system, Baton

Rouge, Louisiana; 6Institute for Genomics and Multiscale Biology, Mount Sinai School of

Medicine, New York, New York.

Corresponding author Alan D. Attie, 543A Biochemistry Addition, 433 Babcock Drive, Department of Biochemistry, University of WisconsinMadison, Madison, Wisconsin, (608) 2621372 (Ph), (608) 2639608 (fax), [email protected].

Running Title: Fatty acylcarnitines enhance insulin secretion

Abstract word count: 163

Main text Word count: 3960

Number of tables: 0

Number of figures: 5

Diabetes Publish Ahead of Print, published online June 26, 2014 Diabetes Page 2 of 288

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ABSTRACT

We previously demonstrated that micro 132 and 212 are differentially upregulated in response to obesity in two mouse strains that differ in their susceptibility to obesityinduced diabetes. Here we show the overexpression of microRNAs 132 and 212 enhances insulin secretion (IS) in response to glucose and other secretagogues including nonfuel stimuli. We determined that carnitine acylcarnitine translocase (CACT, Slc25a20) is a direct target of these miRNAs. CACT is responsible for transporting longchain acylcarnitines into the mitochondria for βoxidation. SiRNA mediated knockdown of CACT in βcells led to the accumulation of fatty acylcarnitines, and enhanced IS. The addition of longchain fatty acylcarnitines promoted

IS from INS1 βcells as well as primary mouse islets. The effect in INS1 cells was augmented in response to suppression of CACT. A nonhydrolyzable ether analog of palmitoylcarnitine stimulated IS, showing that βoxidation of palmitoylcarnitine is not required for its stimulation of IS. These studies establish a link between miRNAdependent regulation of CACT and fatty acylcarnitine mediated regulation of IS.

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INTRODUCTION

Cells have evolved mechanisms to regulate fuel utilization in response to changes in

substrate availability. Glucose oxidation leads to inhibition of βoxidation through the production

of malonylCoA, a potent inhibitor of carnitine palmitoyl 1 (CPT1) (1), a gateway

into mitochondrial βoxidation. Conversely, acetylCoA, a product of βoxidation, inhibits

pyruvate dehydrogenase (PDH) (1), a critical in the glycolytic pathway. Fatty acids

potentiate glucosestimulated insulin secretion (IS) (2) and insulin suppresses

. The inhibitory effect of insulin on adipose tissue lipolysis leads to a

decrease in circulating fatty acids and thus comprises a negative feedback loop (3).

The mechanism by which fatty acids regulate IS is not fully elucidated. Acute exposure to

fatty acids stimulates whereas chronic exposure to fatty acids suppresses IS (2). Chronic fatty

acid treatment of βcells in the presence of high glucose leads to a decrease in expression of

Pdx1, a factor (4). Pdx1 is required for pancreatic development (4). Palmitate is

incorporated into , an inhibitor of phosphatidylinositol3 and Akt, both of which

are involved in insulin signaling (5). Loss of activity of these leads to blunted insulin

signaling (1, 6), which has been hypothesized to decrease Pdx1 translocation into the nucleus.

Multiple pathways have been proposed to explain the acute stimulatory effects of fatty acids

on IS. Several conventional PKC are activated by fatty acids, which in turn lead to

increased IS (7). Conversely, fatty acids suppress several novel PKC isozymes that inhibit IS,

leading to enhanced IS (8). Fatty acids acutely regulate cellular Ca2+ levels through activation of

GPR40, leading to enhanced insulin secretion (9).

We previously showed that geneticallyimposed obesity (Lepob/ob) induces the expression of

miRNAs 132 and 212 in pancreatic islets (10). In diabetesresistant C57BL/6J (B6) mice, the

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4 induction was ~13fold, whereas in diabetessusceptible BTBR T (+) tf/J (BTBR) mice, the induction was reduced to ~3fold. In this study, we show that overexpression of these miRNAs enhances IS in response to a variety of secretagogues, suggesting that the strain difference in their regulation may contribute to diabetes susceptibility. We identify the mitochondrial carnitine acylcarnitine translocase (CACT, Slc25a20) as a direct target of the miRNAs that mediates their effect on IS. The downregulation of CACT causes an accumulation of cellular acylcarnitine molecules and enhances their effect on IS.

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MATERIALS AND METHODS

Reagents. Insulin from INS1 cells and mouse islets was measured with an inhouse ELISA

using an antiinsulin from Fitzgerald Industries (Acton, MA). RPMI growth media,

Hanks’ balanced salt solution (HBSS), Lipofectamine2000 was bought from Life Technologies.

Palmitic acid, BSA, PalmitoylLcarnitine, Collagenase type XI, diazoxide (DZX), 8BrcAMP,

L, and SiRNAs against CACT (custom siRNAduplex 5’

CAAAGAAGCUGUAUCAGGA[dT][dT] 5’UCCUGAUACAGCUUCUUUG[dT][dT])

negative control scrambled SiRNAs (. No. SIC001) were all obtained from Sigma Aldrich

(St. Louis, MO). Chemically modified PremiR™ miRNA precursors and negative control #1

were purchased from Ambion (Foster City, CA). RNA and miRNA isolation kits were

purchased from QIAGEN (Valencia, CA). Antibody against CACT was obtained from Abcam

(Cambridge, MA) and antibody against Vdac was a generous gift from Prof. Dave Pagliarini,

University of WisconsinMadison. The goat antirabbit secondary were purchase from

Cell Signaling Technology (Boston, MA). The 14CPalmitic acid, 14CPalmitoylLcarnitine, and

14CUGlucose were all purchased from Perkin Elmer, Inc. POC16 was a generous gift from the

Bronfman lab, Pontificia Universidad Católica de Chile. The pmirGLO dual construct

was a generous gift from the Sugden lab at University of WisconsinMadison.

Cell lines and mouse islet treatments. An INS1derived insulinoma cell line, 832/3 and

832/13, were used in this study. The cells were cultured in RPMI 1640 with 10% FBS and 11

mM glucose, as described (11). Pancreatic islets of Langerhans were isolated from C57BL/6J

mice by collagenase digestion and a Ficoll gradient separation as previously described (11).

Taqman quantitative PCR analysis of selective miRNAs. Fluorogenic Taqman probes for

miRNAs132, 212, and 375 were purchased from Applied Biosystems. Relative expression

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6 levels for miRNAs of interest were determined by realtime qPCR using the ABI PRISM 7900

Sequence Detection System from Applied Biosystems. The mRNA level of the Insulin1

(the predominant isoform in INS1 cells) was detected by Taqman quantitative PCR using specific probe from Applied Biosystems and normalized to β mRNA levels.

Transfection of INS1 cells with siRNA/miRNA oligonucleotides. SiCACT and negative

control oligonucleotides were transfected into INS1 832/13 or 832/3 using Lipofectamine2000

as described previously (11). Approximately 80 nmoles of oligonucleotides were used per

500,000 cells transfected. Experiments illustrated in Figures 2, S1, S2, and S3 were performed

using the INS1 832/3 subclone, whereas the remaining experiments utilized the 832/13 sub

clone. In our experience, 832/13 cells are generally more adherent and, therefore, more amenable

to our studies. The effect of PC or the miRNAs on insulin secretion is observed equally in both

subclones of the INS1 cells (data not shown).

Generation of adenovirus overexpressing miRNA oligonucleotides. Adeno

overexpressing miRNAs 132, 212, and 375 were generated in the Duke University core

adenovirus lab as described in supplementary Table S2. The forward and reverse

oligonucleotides were then cloned into a Gateway entry plasmid, pENTR1A (Invitrogen), driven

by the H1 , and a GFP expression cassette driven by CMV promoter.

Infection of INS1 cells with adenovirus overexpressing miRNA oligos. 24 hrs after seeding,

cells were treated with the adenoviruses at an MOI of 10 in OPTIMEM transfection media for 2

hrs. 48 hrs later, cells were used for the IS and luciferase reporter studies, or harvested for

western blot analysis.

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IS assay. The IS assay in INS1 cells, and mouse islets was performed as previously described

(11). The mouse islet IS experiment evoked by PCBSA included a digitonin pretreatment (20

µg/ml, 20 mins, 37°C) to achieve improved penetration of PC as described previously (12).

Microarray expression profiling. MiRNAs 132 and 212 were overexpressed using

oligonucleotides in INS1 832/3 cells. Cells were harvested at 10 and 24 hrs both. RNA was

extracted from the lysate using the QIAGEN (RNeasy) . RNA array hybridizations were

performed at Rosetta Inpharmatics (Seattle, WA). Profiling was performed as previously

described (13). MRNAs were considered to be differentially expressed (DE) if they were in the

top 5% of altered due to miRNA upregulation.

CACT quantification. 48 hours post infection/transfection, cells were harvested by a

western lysis buffer containing (20 mM TrisHCl (pH 7.5), 150 mM NaCl, 1 mM Na2EDTA, 1

mM EGTA, 1% Triton, 2.5 mM sodium pyrophosphate, 1 mM βglycerophosphate, 1 mM

Na3VO4, 1 µg/ml leupeptin, 0.5mM NaF, PMSF and 1 protease inhibitor cocktail tablet.). The

cell lysates were sonicated and centrifuged at 13,000 x g for 10 min. The supernatant was

discarded and the pellet was resuspended and sonicated in the same western lysis buffer with

additional 1% SDS. CACT protein was detected using a rabbit antiSlc25a20 polyclonal

antibody from Abcam at a dilution of 1:1000. The CACT protein intensity was normalized to

Vdac, an abundant mitochondrial protein, which was detected using a rabbit antiVdac

polyclonal antibody at a dilution of 1:2000. Secondary goat antirabbit antibody was used at

1:5000 dilution. The immunobloting was performed using a standard protocol (11).

Luciferase assay. The 3’UTR of the rat CACT gene was fused behind the gene in the

pmirGLO expression construct (Promega). This construct also contained a renilla luciferase

gene, which was used to normalize for transfection efficiency according to manufacturer

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8 directions. 24 hrs after seeding, INS1 832/3 cells were transfected with pmirGLO with or without cotransfection of either AdGFP, AdmiR132 or AdmiR375 (MOI, 10). 48 hrs later, we measured luminescence in INS1 cells in a Tecan M1000 micro plate reader.

Palmitic acid and Palmitoyl carnitine conjugation to BSA. Palmitic acid was conjugated to

BSA by mixing 67 µl of 25 mg/ml palmitate solution (heated to 70 °C ), to 933 µl of 70 mg/ml

BSA solution at 70°C to yield a final concentration of 6 mM palmitate. Palmitoyl carnitine (and also POC16) was conjugated to BSA using the protocol described in Brockenbrough, J.S. et. al.

(14). Briefly, palmitoylLcarnitine (100 mM) was added to a 3.3% BSAcontaining KREBs

Ringers solution, and heated to 45°C for 5 mins to obtain a 1 mM stock solution of PCBSA.

βoxidation assay. 48 hours after transfection/infection, the cells were maintained in 1.5 mM

glucose for 2 hours, followed by a 2 hour treatment with palmitic acid (PA, 300 M with 0.5

Ci/ml 14CPA), palmitoylLcarnitine (PC, 50 M with 0.1 Ci/ml 14CPC) and 1.5 mM glucose

and 1 mM Lcarnitine. Following the 2hr incubation period, cellular media were transferred into

sealed scintillation vials with a small eppendorf tube containing 0.3 ml of 1N NaOH. To liberate

14 gaseous CO2 from the media, 0.1 ml of 70% perchloric acid was added, the vials resealed and

maintained at room temperature overnight, resulting in accumulating the CO2 in the base. The

14 amount of CO2 produced was determined by liquid scintillation counting of 0.3 ml of the base and the amount of acid soluble metabolites (15) were determined by measuring the amount of

14Clabeled metabolite remaining in the media after perchloric acid precipitation.

Glucose oxidation assay. Glucose oxidation is measured using the same protocol described

above for βoxidation. Cell were treated with 15 mM glucose containing 0.5 Ci/ml 14Cglucose for CO2 production.

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Acylcarnitine profiling in INS1 cells. After transfection, cells were cultured in RPMI media

supplemented with 1 mM Lcarnitine for 48 hrs. Following this, cells were maintained in 1.5

mM glucose for 2 hours, then followed by a 2 hour treatment with or without 50 µM (16) for 2

hours in KRB (11) buffer containing 1.5 mM Glucose. Cells were then harvested and acyl

carnitine were determined by MS/MS spectrometry as previously described (17).

GPR40 assay. The GPR40 assay was performed as shown in (18).

Expression of data and statistical analysis. Data are expressed as mean ± SEM. Statistical

significance was determined using a Student’s t test where two conditions were compared, and a

2way ANOVA was used in cases where more that two conditions were compared. Pvalue <

0.05 was considered statistically significant.

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RESULTS

MiRNAs 132 and 212 enhance IS from pancreatic βββcells.

To evaluate the effects of miRNA 132 on βcell function, we used an adenovirus (Ad) to

overexpress the miRNA in INS1 832/13 cells, while monitoring IS. Under these conditions, IS

was significantly augmented in response to multiple secretagogues; glucose, KCl, diazoxide with

high glucose, cyclic (cAMP), and Larginine (Fig. 1). In contrast,

miRNA132 did not stimulate insulin secretion at basal glucose (1.5 mM). MiRNA212

overexpression also stimulated IS in the presence of glucose and KCl (Fig. S1A). The miRNAs

132 and 212 did not alter insulin mRNA or protein expression (Fig. S1B & C), indicating that the

miRNAs stimulate IS by modulating the insulin secretory pathway. The effects of miRNA132

on insulin secretion are consistent with a recent report (19). Our positive control, miRNA375,

suppressed insulin secretion (Fig. S1A) without altering insulin mRNA or protein (Fig. S1B &

C), as previously reported (20). Our negative control, AdGFP did not affect IS compared to

nontreated (NT) cells (Fig. S2).

The mitochondrial carnitine acylcarnitine translocase (CACT) is a direct target of

miRNAs 132 and 212.

While we and another group (19) have shown that miRNAs 132 and 212 stimulate IS, the

molecular targets of the miRNAs were unknown. To identify putative targets that mediate the

effects of miRNAs 132 and 212 on IS, we overexpressed the miRNAs in INS1 832/3 cells,

followed by wholegenome microarray profiling at 10 (Fig. S3A) and 24 hours (Fig. 2A).

Approximately 3,000 genes were differentially expressed (DE) in response to the miRNAs at both time points (supplementary excel files (SE1)). Of these two sets of DE genes (assessed at 10

and 24 hrs), ~60% were common. Interestingly, only ~14% of the DE genes contained a seed

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region for the miRNAs, suggesting that the majority of the DE genes may be indirect targets of

the miRNAs. At 10 and 24 hrs, the mitochondrial carnitine acylcarnitine translocase (CACT)

was the most downregulated gene (reduced by ~80%) in response to the overexpression of

miRNA 132 or 212. In addition, miRNA132 caused a ~60% decrease in CACT protein

abundance (Fig. 2B).

To demonstrate that CACT mRNA is a direct target of miRNA132, we cloned the 3’UTR of

CACT into a vector encoding firefly luciferase and renilla. The overexpression of miRNA132

resulted in a significant loss (~40%, p < 0.001) in luciferase activity, whereas miRNA375 was

without effect (Fig. 2C). Taken together, these data provide strong evidence that miRNA132

directly targets CACT expression, leading to a reduction in CACT protein.

Downregulation of CACT enhances IS from pancreatic βββcells.

SiRNA oligonucleotides are more specific than miRNAs for their mRNA targets. To

determine if CACT is a target gene responsible for the effect of miRNAs 132 and 212 on IS, we

asked if siRNAs that were designed to selectively suppress CACT mimic the effect of the

miRNAs on IS. SiRNAmediated suppression of CACT (~60% mRNA and ~40% protein, Fig

S4A & B) resulted in an increase in IS in response to basal glucose (Fig. 3A), and in addition, to

all the secretagogues shown to be affected by miRNA 132 (Fig. 1).

CACT is located in the inner mitochondrial membrane and mediates the influx of fatty acyl

carnitine esters into the mitochondria in preparation for βoxidation (21). We hypothesized that

the miRNAdependent downregulation of CACT leads to reduced βoxidation, and elevates

cellular levels of acylcarnitine molecules, which in turn promote IS.

To test this hypothesis, we first asked if a longchain fatty acylcarnitine stimulates IS when

directly added to pancreatic βcells. PalmitoylLcarnitine (16), at 1550 µM, resulted in a dose

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dependent increase in IS in the presence of 1.5 mM glucose (Fig. 3B). Knockdown of CACT by

siRNAs further increased the effect of PC on IS. In addition to INS1 832/13 cells, PC promoted

a dosedependent increase in IS from cultured mouse islets (Fig. 3C).

In addition to PC, 50 µM stearoylcarnitine also promoted IS from INS1 832/3 βcells (Fig.

S5). Finally, 600 µM nonesterified palmitate augmented IS when acutely added to INS1 832/3

cells (Fig. S5), as has been previously reported (2).

CACT knockdown reduces βoxidation.

A reduction in CACT protein may lead to reduced βoxidation due to diminished mitochondrial import of acylcarnitine molecules. By decreasing the production of acetylCoA, glucose oxidation may increase, due to derepression of pyruvate dehydrogenase, as predicted by the Randle Hypothesis (1). To discriminate between reduced βoxidation and enhanced glycolysis in response to knockdown of CACT, we measured rates of palmitate, palmitoylL carnitine, and glucose oxidation in INS1 832/13 cells. Palmitate and palmitoylLcarnitine oxidation were significantly reduced by siRNA against CACT and by miRNA 132 (Fig. 4A &

B). Glucose oxidation was significantly suppressed by siRNA against CACT, whereas miRNA

132 caused a small increase in glucose oxidation (Fig. 4C).

CACT knockdown increases cellular acylcarnitine levels.

We used mass spectrometrybased metabolic profiling to survey the pool of acylcarnitines in

INS1 832/13 cells in the presence and absence of exogenous acylcarnitine (50 µM PC). In response to siRNAmediated knockdown of CACT, we found that longchain acylcarnitine esters, ranging from C14 to C20, were significantly increased (1.5 2 fold, p < 0.05) (Fig. 4D).

PC resulted in a significant elevation in carnitine esters of short and long chain lengths in response to CACT knockdown (Fig. 4E). This experiment was perfomed while maintaining a

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chronic exogenous level of Lcarnitine (1 mM for 48 hours) to insure that free carnitine levels

were not limiting for Cpt1 activity. These studies were repeated in the absence of exogenous L

carnitine (Fig. S6A & B), revealing that under these conditions CACT knockdown led to an

increase in fewer longchain acylcarnitines. Absolute concentrations for all acylcarnitine

molecules profiled in both studies are provided in the supplemental file (SE2).

A nonhydrolyzable palmitoylcarnitine (POC16) analog enhances IS.

To determine if longchain carnitine esters are direct insulin segretagogues, we asked if a

non hydrolyzable analog of PC promotes IS. In contrast to PC, the POC16 analog lacks the C1

carbonyl group and contains an alcohol attached to C2, yielding an ether linkage between the

fatty acyl group and carnitine (Fig. 5A). This ether linkage renders POC16 nonhydrolyzable

(22). We hypothesized that if PC is a direct signaling molecule that affects IS, then POC16

should mimic the effect of PC. POC16 was as effective as PC to promote IS (Fig. 5B & 3B).

POC16 enhanced IS at basal glucose by ~90%, and when coupled with knockdown of CACT,

the effect was augmented ~2.5fold. This supports our hypothesis that cytosolic PC acts directly

to promote insulin secretion.

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DISCUSSION

In this study, we show that fatty acylcarnitines are potent stimulators of IS. Upregulation of miRNAs 132 and 212 in pancreatic βcells results in CACT suppression. CACT inhibition leads to inhibition of βoxidation and accumulation of cellular longchain fatty acylcarnitine esters. In addition to carnitine esters, we also show that POC16, a non hydrolyzable analog of PC (22), is capable of enhancing IS (Fig. 5B), suggesting that the bond between the hydrocarbon and carnitine does not need to be hydrolyzed in order to stimulate IS.

The role of fatty acids in IS has been extensively studied. Prentki and coworkers showed

that overexpression of a mutant form of CPT1 that is insensitive to malonylCoA leads to

enhanced βoxidation and impaired IS (23). Furthermore, islets from mice deficient in PPARα

have decreased βoxidation and increased IS (24, 25). However, Newgard and coworkers have

shown that overexpression of malonylCoA decarboxylase leads to increased βoxidation without

affecting IS (26, 27). However, these studies did not measure acylcarnitines during

manipulations of βoxidation. Our data supports an inverse relationship between βoxidation and

IS; reduced oxidation leads to increased secretion in parallel with increases in longchain acyl

carnitines. Prentki, in a recent review, also suggests that CPT1 is a negative modulator of IS,

which when highly active, channels free fatty acids for βoxidation, decreasing the production of

amplification signals of IS (2). Recent studies by Coleman and Newgard have also shown

the importance of acylCoAs and that of acylCoA synthetase for IS (28). These studies

collectively demonstrate the importance of fatty acids and their analogues on IS.

MicroRNAs 132 and 212 are located within ~200 base pairs of each other in the rat, mouse,

and human genomes, suggesting that they are likely generated from a common primary miRNA precursor molecule (29). These miRNAs have a ~75% sequence similarity and a ~97% similar

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list of putative target genes (30). 132 and 212 have been identified through a

genomewide screen as a target of the , cAMPresponse element binding

protein (29). Accordingly, expression of these miRNAs is increased in response to an elevation

in cellular cAMP, a signaling molecule that is critical for IS and βcell survival (31, 32). Recent

publications have also shown that along with obesity and diabetes, high fat feeding leads to an

increase in the levels of miRNA 132 (19). In our mouse models, miRNAs 132 and 212 were both

upregulated in islets in response to obesity, but to a lesser extent in diabetic mice. Moreover, our

data shows that CACT, a direct target of the miRNAs, is highly upregulated in diabetic obese

mice compared to nondiabetic obese mice (33). These results suggest that the miRNA

dependent downregulation of CACT may be a mechanism to enhance the insulin secretory

response.

In , CACT deficiency is a rare autosomal recessive disease and is characterized by a

diminished capacity for βoxidation, which can lead to variety of severe metabolic disorders,

including hypoketotic hypoglycemia, hyperammonemia, cardiac and hepatic dysfunction,

weakness, and (21, 34). These phenotypes primarily reflect

defects in muscle and hepatic βoxidation. An early diagnostic criterion for CACT deficiency in

humans is accumulation of plasma longchain acylcarnitines (21). Deletion of steroid

coactivator3 in mice, which regulates CACT, leads to similar metabolic consequences as

CACT deficiency (35). Our results demonstrate that these same lipid classes significantly

increase in βcells in response to CACT knockdown (Fig. 4D and E). Longchain fatty acyl

carnitines showed a stronger correlation with IS (Fig. 3B) than did shortchain fatty acyl

carnitines, with the exception of C5 (Table S2). This agrees with previous findings indicating

that longchain fatty acids are more potent insulin secretagogues (7). C5 carnitine inhibits β

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16 oxidation by antagonizing butyrylCoA and octanoylCoA dehydrogenase (36). However, others have argued that acylcarnitines are not associated with the regulation of IS. Glasgow, et.al. measured steadystate insulin in response to chronically elevated long chain acylcarnitines (37), whereas we focused our studies on acute regulation of IS. Pepin, et.al. show that acute exposure to L3hydroxybutyrate or L3hydroxyglutarate did not change IS (38). However, our studies utilized longchain fatty acylcarnitines.

Surprisingly, we observed a slight decrease in glucose oxidation in response to CACT knockdown in addition to reduced βoxidation. Since CACT is responsible for a bidirectional flux of acylcarnitines, it is possible that CACT knockdown leads to an accumulation of acetyl

CoA in the , leading to inhibition of glycolysis.

Our results demonstrate that longchain acylcarnitine esters are insulin secretagogues. Fatty acylCoA molecules have been widely studied for their role in promoting IS (39), however the mechanism is not well understood. PalmitoylCoA accumulation is known to increase protein acylation, which also leads to increased IS (40). Studies involving a neuroblastoma cell line show that in addition to palmitoylCoA, PC could also be involved in protein palmitoylation

(41). However, POC16 is is not a substrate for protein palmitoylation, suggesting that PC is unlikely to regulate IS through palmitoylation. Fatty acids have also been shown to regulate cellular Ca2+ levels through activation of GPR40 (40), leading to enhanced IS. However, we did not observe an effect of PC on GPR40 activation. (Fig. S7).

PC negatively regulates conventional and atypical PKCs (42, 43). In addition, POC16 suppresses conventional PKCs (17). Phosphatidylserine (PS) rescues the inhibitory effect of

POC16 on cPKC activity, suggesting that POC16 may bind to the PSbinding domain on PKCs

(42). PS binds to both the C1 and C2 domains of PKCs (44), indicating that PC could act as a

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for either or both of these domains. PKCs have been shown to be positive (22, 42) as well

as negative regulators of IS (44), indicating that PC could act as a ligand for either or both of

these domains. PKCs have been shown to be positive (45, 46) as well as negative regulators of IS

(47, 48).

SiCACT enhanced IS at low glucose, suggesting that acylcarnitines do not require glucose

metabolism to influence IS. Several key components of the insulin secretory machinery, e.g.,

and Munc13 homologs, contain C1 and/or C2 domains (49), raising the

possibility that fatty acylcarnitines may directly interact with these to regulate their

function. Cytosolic accumulation of fatty acylCoA due to reduced βoxidation can lead to

increased synthesis of diacylglycerol (DAG), monoacylglycerol (MAG), and (PL)

(2, 7). A recent study by Prentki and coworkers suggests that MAGs can bind the C1 domain of

Munc131, a critical protein involved in vesicle , and thus mediate enhanced insulin

exocytosis (50).

In addition to stimulating secretion by binding exocytosismediating proteins, PC, and other

acylcarnitines activate voltagedependent calcium channels (51). The effect of PC on Ltype Ca

channels can be a suppression or an activation (52, 53), depending on experimental conditions.

PC activates the responsible for intracellular calcium induced calcium

response (54). PC has also been shown to inhibit KATP channels in ventricular myocytes (55),

suggesting a mechanism by which PC could promote Ca2+ influx, leading to enhanced IS.

Acylcarnitines have recently become a biomarker in metabolic syndrome (56, 57). Our

studies show that fatty acylcarnitines are potent insulin secretagogues. These molecules are

elevated in the sera of patients with insulin resistance (56). Elevated acylcarnitine molecules, as

we observe with CACT supression, or in humans with CACT (21), could be associated

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18 with the increased IS that occurs in subjects with metabolic syndrome. The resulting hyperinsulinemia could lead to insulin resistance.

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ACKNOWLEDGEMENTS

We are very grateful for the generous support and advice of Dr. Christopher Newgard (Duke

University) We thank Prof. Miguel Bronfman (Catholic University, Chile) for generously

donating the POC16 compound, and Alberto Guerra and Aron Haun for their technical

assistance. The project described was supported by the Clinical and Translational Science Award

(CTSA) program, through the NIH National Center for Advancing Translational Sciences

(NCATS), grant UL1TR000427. This work was also supported by NIHDK56593 and NIH

DK66369 (A.A.); COBRE (NIH8P20GM103528), NORC (NIH2P30DK072476), ADA1

10BS129, NIHR01DK089641 (R.M.); and NIHR01DK089312 (D.M.M.).

M.S. carried out experiments and cowrote the manuscript. S.B. provided technical advice and

support. J.S., M.R., O.I., R.M., Y.Z. carried out experiments. E.S. and N.T. helped to design the

study. D.M. supervised the metabolomics analysis and helped to interpret results. M.K. co

managed the project. Neither of the authors have raised a conflict of interest regarding the

submission of this article. A.A. supervised the project, the interpretation of the data, and the

preparation of the manuscript. A.A. is also the guarantor of this work and had full access to the

data in the study and takes responsibility for the integrity of the data and the accuracy of the data

analysis

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FIGURE LEGENDS

Fig. 1. MicroRNA132 enhances IS from pancreatic βcells. The ratderived βcell line, INS1

832/13 was infected with adenovirus overexpressing AdmiRNA132, or AdGFP (negative

control). 48 hrs after infection, IS was measured in response to increasing glucose

concentrations, or various combinations of glucose and KCl (40 mM), Diazoxide (DZX, 250

µM), cAMP (3 mM cAMP), or Larginine (Arg, 15 mM). IS is normalized to total cellular protein and expressed as insulin secretion (ng) normalized for total protein (58). Each condition

was performed for n = 6 times. *p < 0.05; **p < 0.01; ***p < 0.001.

Fig. 2 MicroRNA132 directly targets CACT for downregulation. (A)

profiling in INS1 832/3 cells following miRNA overexpression. Differential expression (DE)

resulting from miRNA132 is plotted against DE for miRNA212, 24hrs following

overexpression of the miRNAs using oligonucleotides (p < 0.05). Larger symbols indicate

greater statistical significance for DE. Axes show the log10 of the foldchange (miRNA over negative control). Negative values indicate downregulation of expression. CACT is highlighted as the most downregulated gene in response to both miRNAs. (B) MiRNA132 decreases

CACT protein level. Western blot analysis was used to evaluate the effect of miRNA132 on

CACT protein levels in INS1 832/3 cells. Adenoviruses were used to overexpression either miRNA132 or GFP. Cells were harvested 48 hours after infection and 25 µg of protein was

loaded per lane; Vdac protein was used to normalize loading. Blot is representative of 3

independent experiments. (C) CACT is the direct target of miRNA132. INS1 832/3 βcells

were transfected with a dual luciferase reporter construct that contained the 3'UTR for rat CACT

gene, and one of three viruses (MOI 10), AdGFP, AdmiR375 or AdmiR132 (n=3

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experiments for each condition). 48 hours later, luminescence was measured in the cells. *p <

0.05; **p < 0.01; ***p < 0.001.

Fig. 3. Longchain carnitine esters are potent insulin secretagogues. (A) CACT knock

down enhances IS. IS from INS1 832/13 βcells was measured in response to siRNAmediated

knockdown of CACT. Cells were transfected with siRNA against CACT or a scrambled

oligonucleotide while plating cells (reverse transfection) and incubated for 48 hrs before

measuring IS. IS was measured in response to increasing glucose concentrations (1.5, 7 and 15

mM); elevated KCl (40 mM) at 15 mM glucose; a combination of elevated KCl, 15 mM glucose

and 250 µM diazoxide; or 3 mM cAMP or 15 mM Larginine at 7 mM glucose. IS is normalized

to total cellular protein and expressed as insulin secretion (ng) normalized for total protein (58).

Each condition was performed for n ≥ 5 times. (B) PC mimics the stimulatory effect of CACT

knockdown on IS. IS was measured in INS1 832/13 cells in response to exogenous PCBSA

(15, 30, and 50 M) alone or in combination with CACT suppression by siRNA

oligonucleotides. Cells were transfected with siRNAs CACT or negative control

oligonucleotides (ScrsiRNA). 48 hrs later, IS was stimulated with 1.5 mM glucose alone or in

the presence or absence of PCBSA. IS is normalized to total cellular protein. Experiments were

done a total of n = 3. Anova calculation showed that #pvalue < 0.01 for dose dependent effect of

PCBSA compared to no addition of PC on either scrambeled or siCACT transfected cells. ***P

value < 0.001 for effect of CACT knockdown. (C) PC potentiates IS from primary mouse

islets. Islets were isolated from B6 mice and used for ex vivo IS assays. After purification, islets

were maintained in KRB media at 1.7 mM glucose for 20 minutes in the presence of digitonin

(20 µg/ml) and then for 45 mins without digitonin (preincubation), followed by a 45 min

incubation with 1.7 mM glucose in the presence of 10, 25, and 50 M PC to stimulate IS. IS was

Diabetes Page 22 of 288

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quantified using an insulin ELISA and normalized to total insulin content in islets. All

experiments are performed n = 3 times (except the effect at 10 µM PCBSA was observed n = 2

times) . *p < 0.05; **p < 0.01; ***p < 0.001.

Fig. 4. CACT knockdown reduces βoxidation and leads to acylcarnitine accumulation. (A,

B, & C) siCACT and miRNA 132 both blunt βoxidation. INS1 832/13 cells were transfected with CACT siRNAs or scrambled (Scr) oligonucleotides as negative control, or infected with

14 AdGFP or AdmiRNA132. 48 hrs post transfection / infection, (A) palmitate oxidation ( CO2

14 released and ASM), (B) palmitoylcarnitine oxidation ( CO2 released and ASM) and (C) glucose oxidation was measured as described in methods. Units for all the graphs are nmol 14C/

mg protein/. (D & E) Metabolic profile demonstrates an accumulation of acylcarnitines in

response to CACT downregulation. INS1 832/13 cells were transfected with CACT siRNAs or control oligonucleotides (ScrsiRNA) and maintained for 48 hrs in RPMI supplemented with 1 mM Lcarnitine. Two hours prior to harvesting the cells for metabolic profiling, the culture medium was refreshed without (D) or with (E) PC (50 µM) and 1.5 mM glucose. All metabolite measurements in response to CACT siRNA is normalized to control measurements. All bars represent statistically significantly upregulation in metabolites. *p < 0.05; **p < 0.01; ***p <

0.001. All experiments were performed n ≥ 3 times.

Fig. 5. A nonhydrolyzable analog of palmitoyl carnitine enhances glucose stimulated IS.

(A) Molecular structure of PC and POC16, an analog of PC where the linkage between the and carnitine is replaced by an ether linkage with C16. (B) POC16 stimulates IS

from INS1 832/13 cells. IS was monitored 48 hrs after cells were treated with either CACT

Page 23 of 288 Diabetes

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siRNAs or negative control siRNAs (Scr) in the presence or absence of POC16 (10 µM,

conjugated to BSA) and 1.5 mM glucose. Insulin secreted was normalized to total cellular

protein. Experiment was performed n = 4 times.

Diabetes Page 24 of 288

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SUPPLEMENTARY FIGURE LEGENDS

Fig. S1. (A) MicroRNA 212 enhances IS from pancreatic βcells. INS1 832/3 βcells were transfected with precursors for miRNAs 212, 375, or negative control oligonucleotides. 48 hrs after transfection, IS was measured in response to varying glucose concentrations or elevated

KCl. IS into the medium is normalized to total insulin content. Data is representative of 5 independent experiments. Insulin transcript expression and protein content in INS1 cells did not change after transfection with precursors of miRNAs – 132 and 212. Insulin transcript (B) and insulin protein content (C) were measured from the lysates of cells transfected with premiR

132, premiR212, premiR375 or a PremiRTM negative control. Insulin content was normalized

to total protein. *p < 0.05; **p < 0.01; ***p < 0.001 as compared to the negative control.

Fig. S2 AdenovirusGFP does not affect insulin secretion. INS1 832/3 cells were either left

untreated (NT) or transfected with AdGFP. 48 hrs after infection, IS was measured in response

to 15 mM Glucose. IS is normalized to total insulin content, and depicted as % of fractional

release. Graph is an average of n = 6 experiments.

Fig. S3 CACT is the most downregulated mRNA in response to miRNA 132 and 212

overexpression. Differential expression (DE) of mRNA resulting from miRNA132 is plotted

against DE resulting from miRNA212, 10hrs following introduction of miRNA

oligonucleotides into INS1 832/3 βcells (p<0.05). Larger symbols indicate greater statistical

significance for DE. ~6.7 % of the depicted mRNA has a seed region. Axes show the log10 of the foldchange (miRNA over negative control). Negative values indicate downregulation of expression. CACT is highlighted as the most downregulated gene in response to both miRNAs.

Page 25 of 288 Diabetes

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Fig. S4. CACT (A) mRNA and (B) protein abundance is downregulated in response to

siRNA oligonucleotides against CACT. (A) RNA was isolated and CACT expression levels

were measured using qPCR methods (described in the methods section) 48 hours post

transfection with siCACT oligonucleotides. *p < 0.05 as compared to the negative control. (n =

4) (B) siRNACACT decreases CACT protein level. Western blot analysis was used to

evaluate the effect of CACT siRNA on CACT protein levels in INS1 832/3 cells. INS1 832/13

cells were transfected with CACT siRNA or negative control (ScrsiRNA) 832/13 βcells. Cells

were harvested 48 hours after transfection and 25 µg of protein was loaded per lane; Vdac

protein was used to normalize loading. Blot is representative of 4 independent experiments.

Fig. S5. SteroylLcarnitines enhances IS. 48hrs after plating INS1 832/3 cells, IS was

measured in response to 7 mM glucose alone or in the presence of stearoylcarnitine (50 M) or

palmitic acid (600 M). Insulin secreted is normalized to total cellular insulin content and data is

expressed relative to 7 mM glucose alone (NT) (2 hrs, n>4). *p < 0.05; **p < 0.01; ***p <

0.001.

Fig. S6 (A & B) Metabolic profile demonstrates a subtle increase in longchain acyl

carnitines in response to CACT downregulation. INS1 832/13 cells were transfected with

CACT siRNAs or control oligonucleotides (ScrsiRNA) and maintained for 48 hrs in RPMI

supplemented without any exogenous Lcarnitine. Two hours prior to harvesting the cells for

metabolic profiling, the culture medium was refreshed without (A) or with (B) PC (50 µM) and

1.5 mM glucose. All metabolite measurements in response to CACT siRNA is normalized to

Diabetes Page 26 of 288

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control measurements. All experiments were performed n = 3 times. *p < 0.05; **p < 0.01; ***p

< 0.001.

Fig. S7. PalmitoylLcarnitine cannot activate GPR40. GPR40/CHO nuclear factor of activated Tcells βlactamase cells were seeded into blackwall clearbottom 384well plates

(Costar) 1 day before the assay. The cells were incubated with Hanks’ buffered salt solution buffer with 0.1% BSA, 2.5 mmol/l probenecid, and 8 mol/l Fluo4AM at room temperature for

100 min. Fluorescence output was measured using a fluorometric imaging plate reader (FLIPR)

assay. Compund A, linoleic acid, acetylcarnitine and palmitoylcarnitine were added to observe

their effect on GPR40 activity. Experiment was repeated twice.

SUPPLEMENTARY TABLE LEGENDS

Table S1. Acylcarnitine molecules profiled by Mass spec and their correlation with IS.

This table enlists all the acylcarnitine moelcules that were surveyed by the Mass spec profilfing

experiment. Column two of the table shows the coefficient of correlation of each metabolite with

the IS effect depicted in Fig. 3B. Column three shows if the metabolite was significantly

different between siCACT and Scrambled treated cells in the absence or presence of exogenous

PC (50µM). *p < 0.05; **p < 0.01; ***p < 0.001.

Table S2. Generation of adenovirus overexpressing miRNA oligonucleotides. An expression cassette of human miRNAs132, 212 or 375 contained the hairpin stem composed of 22 nt sense and antisense sequence of each miRNAs, fused to a loop (19 nt) and flanking sequence that derived from human miRNA30. Expression was controlled by the human H1 promoter.

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To construct the H1miRNA expression cassette, the forward and reverse oligonucleotides

containing the respective miRNA sense and antisense sequence, miRNA30 flanking sequence

and loop, BamHI and HindIII overhang were first synthesized as a pair of complementary

antiparallel oligonucleotides. The forward and reverse oligonucleotides mentioned above were

then annealed and ligated into a Gateway entry plasmid pENTR1A (Invitrogen), containing the

human H1 promoter and a GFP expression cassette driven by CMV promoter. H1miRNA

CMVGFP cassette in pENTR1A plasmid was recombined into Gatewaybased pAdBlockiT

DEST vector (Invitrogen). AdmiRNAs were produced in HEK293 cells and purified by CsCl

density gradient ultracentrifugation. The purified was desalted by dialysis and concentrated

over CentriPrepYM50 column before use.

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REFERENCES 1. Randle, P.J., et al., The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1963. 1(7285): p. 785-9. 2. Prentki, M., F.M. Matschinsky, and S.R. Madiraju, Metabolic signaling in fuel-induced insulin secretion. Cell Metab, 2013. 18(2): p. 162-85. 3. Zechner, R., et al., Adipose triglyceride and the lipolytic catabolism of cellular fat stores. J Lipid Res, 2009. 50(1): p. 3-21. 4. Gremlich, S., et al., Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels. J Biol Chem, 1997. 272(48): p. 30261-9. 5. Kelpe, C.L., et al., Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. J Biol Chem, 2003. 278(32): p. 30015-21. 6. Littman, E.D., et al., Role of C isoenzymes in fatty acid stimulation of insulin secretion. Pancreas, 2000. 20(3): p. 256-63. 7. Yaney, G.C., H.M. Korchak, and B.E. Corkey, Long-chain acyl CoA regulation of and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology, 2000. 141(6): p. 1989-98. 8. Majumdar, S., et al., Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and -dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl . J Biol Chem, 1991. 266(14): p. 9285-94. 9. Itoh, Y., et al., Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. , 2003. 422(6928): p. 173-6. 10. Zhao, E., et al., Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome, 2009. 20(8): p. 476-85. 11. Bhatnagar, S., et al., Positional cloning of a type 2 diabetes quantitative trait ; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet, 2011. 7(10): p. e1002323. 12. Colca, J.R., et al., Protein in permeabilized pancreatic islet cells. Biochem J, 1985. 228(3): p. 529-36. 13. Su, W.L., R.R. Kleinhanz, and E.E. Schadt, Characterizing the role of miRNAs within gene regulatory networks using integrative genomics techniques. Mol Syst Biol, 2011. 7: p. 490. 14. Brockenbrough, J.S. and M. Korc, Inhibition of epidermal growth factor binding in rat pancreatic acini by palmitoyl carnitine: evidence for Ca2+ and protein kinase C independent regulation. Cancer Res, 1987. 47(7): p. 1805-10. 15. Ramachandran, P., et al., Prospective multi-centre sentinel surveillance for Haemophilus influenzae type b & other bacterial meningitis in Indian children. Indian J Med Res, 2013. 137(4): p. 712-20. 16. Jakupciak, J.P., et al., Mitochondrial DNA as a cancer biomarker. J Mol Diagn, 2005. 7(2): p. 258- 67. 17. Muoio, D.M., et al., Muscle-specific deletion of carnitine compromises glucose tolerance and metabolic flexibility. Cell Metab, 2012. 15(5): p. 764-77. 18. Tan, C.P., et al., Selective small-molecule agonists of -coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. Diabetes, 2008. 57(8): p. 2211-9. 19. Nesca, V., et al., Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes. Diabetologia, 2013. 56(10): p. 2203-12. 20. Poy, M.N., et al., A pancreatic islet-specific microRNA regulates insulin secretion. Nature, 2004. 432(7014): p. 226-30.

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21. Wang, G.L., et al., Expanded molecular features of carnitine acyl-carnitine translocase (CACT) deficiency by comprehensive molecular analysis. Molecular genetics and metabolism, 2011. 103(4): p. 349-57. 22. Garcia-Huidobro, T., et al., Anti-proliferative effect of two novel palmitoyl-carnitine analogs, selective inhibitors of protein kinase C conventional isoenzymes. Eur J Biochem, 1999. 266(3): p. 855-64. 23. Herrero, L., et al., Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion. Diabetes, 2005. 54(2): p. 462-71. 24. Gremlich, S., et al., Pancreatic islet adaptation to fasting is dependent on proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology, 2005. 146(1): p. 375-82. 25. Tordjman, K., et al., PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res, 2002. 43(6): p. 936-43. 26. Mulder, H., et al., Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1- derived (832/13) beta-cells. J Biol Chem, 2001. 276(9): p. 6479-84. 27. Boucher, A., et al., Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue. J Biol Chem, 2004. 279(26): p. 27263-71. 28. Klett, E.L., et al., Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. J Biol Chem, 2013. 288(30): p. 21618-29. 29. Vo, N., et al., A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc Natl Acad Sci U S A, 2005. 102(45): p. 16426-31. 30. Betel, D., et al., Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol, 2010. 11(8): p. R90. 31. Prentki, M. and F.M. Matschinsky, Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev, 1987. 67(4): p. 1185-248. 32. Keller, D.M., E.A. Clark, and R.H. Goodman, Regulation of microRNA-375 by cAMP in Pancreatic beta-Cells. Mol Endocrinol, 2012. 26(6): p. 989-99. 33. Keller, M.P., et al., A gene expression network model of type 2 diabetes links regulation in islets with diabetes susceptibility. Genome Res, 2008. 18(5): p. 706-16. 34. Iacobazzi, V., et al., Molecular and functional analysis of SLC25A20 mutations causing carnitine- acylcarnitine translocase deficiency. Hum Mutat, 2004. 24(4): p. 312-20. 35. York, B., et al., Ablation of steroid receptor -3 resembles the human CACT metabolic myopathy. Cell Metab, 2012. 15(5): p. 752-63. 36. Holland, P.C. and H.S. Sherratt, Biochemical effects of the hypoglycaemic compound pent-4- enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria. Biochem J, 1973. 136(1): p. 157-71. 37. Glasgow, A.M., et al., Hypoglycemia, hepatic dysfunction, muscle weakness, cardiomyopathy, free carnitine deficiency and long-chain acylcarnitine excess responsive to medium chain triglyceride diet. Pediatr Res, 1983. 17(5): p. 319-26. 38. Pepin, E., et al., Short-chain 3-hydroxyacyl-CoA dehydrogenase is a negative regulator of insulin secretion in response to fuel and non-fuel stimuli in INS832/13 beta-cells. J Diabetes, 2010. 2(3): p. 157-67. 39. Stein, D.T., et al., Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest, 1996. 97(12): p. 2728-35.

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40. Roduit, R., et al., A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes, 2004. 53(4): p. 1007-19. 41. Nalecz, K.A., et al., Palmitoylcarnitine regulates estrification of and promotes palmitoylation of GAP-43. FEBS Lett, 2007. 581(21): p. 3950-4. 42. Sobiesiak-Mirska, J., M.J. Nalecz, and K.A. Nalecz, Interaction of palmitoylcarnitine with protein kinase C in neuroblastoma NB-2a cells. Neurochem Int, 2003. 42(1): p. 45-55. 43. Katoh, N., et al., Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+- dependent protein kinases in , and inhibition of their phosphorylation by palmitoylcarnitine. Proc Natl Acad Sci U S A, 1981. 78(8): p. 4813-7. 44. Johnson, J.E., J. Giorgione, and A.C. Newton, The C1 and C2 domains of protein kinase C are independent membrane targeting modules, with specificity for phosphatidylserine conferred by the C1 domain. Biochemistry, 2000. 39(37): p. 11360-9. 45. Harris, T.E., S.J. Persaud, and P.M. Jones, Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors. Biochem Biophys Res Commun, 1996. 227(3): p. 672-6. 46. Uchida, T., et al., Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem, 2007. 282(4): p. 2707-16. 47. Zhang, H., et al., Bimodal role of conventional protein kinase C in insulin secretion from rat pancreatic beta cells. J Physiol, 2004. 561(Pt 1): p. 133-47. 48. Schmitz-Peiffer, C., et al., Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab, 2007. 6(4): p. 320-8. 49. Sheu, L., et al., Regulation of insulin exocytosis by Munc13-1. J Biol Chem, 2003. 278(30): p. 27556-63. 50. Zhao, S., et al., alpha/beta- Domain-6-Accessible Monoacylglycerol Controls Glucose- Stimulated Insulin Secretion. Cell Metab, 2014. 51. Spedding, M. and A.K. Mir, Direct activation of Ca2+ channels by palmitoyl carnitine, a putative endogenous ligand. Br J Pharmacol, 1987. 92(2): p. 457-68. 52. Wu, J. and P.B. Corr, Influence of long-chain acylcarnitines on voltage-dependent calcium current in adult ventricular myocytes. Am J Physiol, 1992. 263(2 Pt 2): p. H410-7. 53. Liu, Q.Y. and R.L. Rosenberg, Activation and inhibition of reconstituted cardiac L-type calcium channels by palmitoyl-L-carnitine. Biochem Biophys Res Commun, 1996. 228(2): p. 252-8. 54. Dumonteil, E., H. Barre, and G. Meissner, Effects of palmitoyl carnitine and related metabolites on the avian Ca(2+)-ATPase and Ca2+ release channel. J Physiol, 1994. 479 ( Pt 1): p. 29-39. 55. Haruna, T., et al., Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes. Pflugers Arch, 2000. 441(2-3): p. 200-7. 56. Sampey, B.P., et al., Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One, 2012. 7(6): p. e38812. 57. Koves, T.R., et al., Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab, 2008. 7(1): p. 45-56. 58. Velasco, R., et al., The genome of the domesticated apple (Malus x domestica Borkh.). Nat Genet, 2010. 42(10): p. 833-9.

Page500 31 of 288 Diabetes** Ad-GFP ** 400 Ad-miR-132

300

200 * ** *** 100 *** total protein (mg) Insulin secreted (ng)/ 0 Glu (mM): 1.5 7 15 15 15 7 7 KCl: Diazoxide: 8-Br-cAMP: Arginine: A Diabetes Page 32 of 288

0.4

0

-0.4 (miRNA/-ve control)) 2 (log -0.8 DE in response to miRNA-212 CACT

-0.8 -0.4 0 0.4 DE in response to miRNA-132 (log2(miRNA/-ve control)) B Ad-GFP Ad-miR-132 C CACT Vdac 100

1.2 80

** 60 0.8

* 40

0.4 20 % Luciferase Activity

Relative protein abundance 0 0

Ad-GFP Ad-GFP Ad-miR-132 Ad-miR-375Ad-miR-132 PageA 33 of 288 Diabetes Scrambled * 250 siCACT * 200

150 * ** 100 *

Total protein (mg) 50 *

Insulin secreted (ng)/ * 0 Glu (mM): 1.5 7 15 15 15 7 7 KCl: Diazoxide: 8-Br-cAMP: Arginine:

B C 6 Scrambled # 12 siCACT * # 5 10 # 4 8 *** # # 3 6 #

4 2 Total protein (mg) (% insulin content) Insulin Secreted (ng)/ 2 1 Insulin secretion (mouse islets) 0 0 0

0 10 20 30 40 50 10 25 50 PC (µM) PC (µM) 1.5 mM Glu β-ox Diabetes PC-ox PageG-ox 34 of 288 14 14 14 A CO2 ASM B CO2 ASM C CO2 0.3 2.0 1.6 60 -3 * *10 4 *** *** 1.5 ** 1.2 * * 0.2 40 * 3

1.0 * 0.8 * * 2 0.1 20 0.5 0.4 1 C - oxidized (nmol/gm prot/hr) C - oxidized (nmol/gm prot/hr) 0.0 C - oxidized (nmol/gm prot/hr) 14 14 0.0 0 0.0 14 0

Scr Scr Scr Scr Scr GFP GFP GFP GFP GFP siCACT miR-132 siCACT miR-132 siCACT miR-132 siCACT miR-132 siCACT miR-132 D E 5 **

4 * * *** 3 ** ** ** * ** ****** ** ** ** ** ** *** ***** ** * ** 2 * * ** * ** ** * * * ** * * * ** * ** * * * 1

Fold change in acyl carnitines 0 C2 C3 C4 C5 C10 C22 C12 C18 C16 C14 C20 C16 C14 C18 C20 C5:1 C16:2 C18:1 C10:2 C14:1 C20:4 C16:1 C18:2 C16:1 C18:1 C4-DC C7-DC C16-OH C8:1-DC C18:1-DC C14:1-OH C18:2-OH C18:2-OH C14:1-OH C12-OH/C10-DC C18-OH/C16-DC C18-DC/C20-OH C14-OH/C12-DC C16:1-OH/C14:1-DC C18:1-OH/C16:1-DC C16:1-OH/C14:1-DC Page 35 of 288 Diabetes A Palmitoyl-carnitine (PC) N OH

15 13 11 9 7 5 3 1 O O 16 14 12 10 8 6 4 2 O

Palmitoyl-carnitine ether (POC-16) N OH OH 111315 9 7 135 O O 16 2468101214

B Scr ** 14 *** siCACT

12

*** 10

8 **

6

4 Insulin secreted (ng)/ total protein (mg) 2

0 0 0 10 10 POC-16 (µM) A 16 Diabetes Page 36 of 288 Control miR-212 miR-375 12 **

*** 8 **

4 Insulin Secretion (% insulin content) *** ** * 0 Glu (mM) : 2 8 16 2 KCl (mM) : 4.7 4.7 4.7 40 B C 1.5 5

4 1.0 3 ** ** 2 0.5 1 Relative Insulin expression

0 Insulin (ng)/ total protein (mg) 0

Scramble Scramble pre-miR132pre-miR212pre-miR375 pre-miR132pre-miR212pre-miR375 Page 37 ofDiabetes 288

6

5

4

3

2

1

Insulin secretion per total insulin content (%) 0 NT

Ad-GFP Diabetes Page 38 of 288 0.4

0.0

-0.4 (miRNA/-ve control)) 2 CACT (log -0.8 DE in response to miRNA-212

-0.8 -0.4 0.0 0.4 DE in response to miRNA-132 (log2(miRNA/-ve control)) Page 39of288 A

Relative Cact expression (%) 100 20 40 60 80 0 Scrambled

siCACT * Diabetes CACT Vdac B Relative protein abundance (%) 100 20 40 60 80

Scrambled 0 c siCACT Scr

siCACT ** Diabetes Page 40 of 288 4

***

3

*** 2

1 Fold change in insulin secretion

0

NT

Palmitic-Acid Stearoyl-carnitine Page 41AB of 288 Diabetes

3.0 *

2.5

2.0 * *** ** * * ** 1.5 ** *** *

1.0 * *** *** * Fold change in acyl-carnitines 0.5

0.0 C8 C3 C12 C16 C14 C18 C10:3 C18:1 C18:2 C16-OH C14:1-OH C14-OH/C12-DC C18-DC/C20-OH C18:1-OH/C16:1-DC 16 Diabetes Page 42 of 288 14

) 12 3 Cpd-A 10 Linoleate 8 PC AC 6 RFU (X10 4 2 0 -8 -7 -6 -5 -4 Log [M] Page 43 of 288 Diabetes

Acyl-carnitine Correl Coeff TTEST C2 0.899825 ** C3 0.857961 * C4 0.878836 * C5:1 0.332214 * C5 0.947179 ** C4-OH 0.81364 C6 0.747288 C5-OH 0.836689 C3-DC 0.741238 * C4-DC 0.725612 C8:1 0.808295 C8 0.732469 C5-DC 0.822696 C8:1-OH/C6:1-DC 0.739477 C8-OH/C6-DC 0.830778 C10:3 0.601103 C10:2 0.78422 * C10:1 0.867477 C10 0.895005 ** C7-DC 0.892962 * C8:1-DC 0.860196 ** C8-DC 0.904018 C12:1 0.720082 C12 0.918573 ** C12-OH/C10-DC 0.961403 C14:2 0.899224 C14:1 0.901048 * C14 0.953624 *** C14:1-OH 0.984939 ** C14-OH/C12-DC 0.934851 ** C16:2 0.9788 ** C16:1 0.970214 ** C16 0.84804 ** C16:1-OH/C14:1-DC 0.95452 ** C16-OH 0.93349 ** C18:2 0.993924 ** C18:1 0.905264 *** C18 0.945182 *** C18:2-OH 0.933865 *** C18:1-OH/C16:1-DC 0.936092 *** C18-OH/C16-DC 0.891945 ** C20:4 0.858913 ** C20 0.826204 ** C18:1-DC 0.320051 * Diabetes Page 44 of 288

C18-DC/C20-OH 0.463094 ** C22 0.442824 **

Page 45 of 288 Diabetes

Primer Sequences

miRNA-132 GATCCCCGGGTATATTGCTGTTGACAGTGAGCGAGACCATGGCTG forward: TAGACTGTTATAGTGAAGCCACAGATGTATAACAGTCTACAGCCA TGGTCGTGCCTACTGCCTCGGACTTCAAGGGTTTTTGGA miRNA-132 AGCTTCCAAAAACCCTTGAAGTCCGAGGCAGTAGGCACGACCATG reverse: GCTGTAGACTGTTATACATCTGTGGCTTCACTATAACAGTCTACAG CCATGGTCTCGCTCACTGTCAACAGCAATATACCCGGG miRNA-212 GATCCCCGGGTATATTGCTGTTGACAGTGAGCGCGGCCGTGACTG forward: GAGACTGTTATAGTGAAGCCACAGATGTATAACAGTCTCCAGTCA CGGCCATGCCTACTGCCTCGGACTTCAAGGGTTTTTGGA miRNA-212 AGCTTCCAAAAACCCTTGAAGTCCGAGGCAGTAGGCATGGCCGTG reverse: ACTGGAGACTGTTATACATCTGTGGCTTCACTATAACAGTCTCCA GTCACGGCCGCGCTCACTGTCAACAGCAATATACCCGGG miRNA-375 GATCCCCGGGTATATTGCTGTTGACAGTGAGCGCCACGCGAGCCG forward: AACGAACAAATAGTGAAGCCACAGATGTATTTGTTCGTTCGGCTC GCGTGATGCCTACTGCCTCGGACTTCAAGGGTTTTTGGA miRNA-375 AGCTTCCAAAAACCCTTGAAGTCCGAGGCAGTAGGCATCACGCGA reverse: GCCGAACGAACAAATACATCTGTGGCTTCACTATTTGTTCGTTCG GCTCGCGTGGCGCTCACTGTCAACAGCAATATACCCGGG

Diabetes Page 46 of 288

DE Gene Symbol Accession Number Log(Ratio) P-value March3 NM_001007759 0.12 0.02 mRNAs colored red contain seed region against both miRNA-132 and 212 March5 XM_001080178 0.08 1.51E-07 Sept4 NM_001011893 0.09 0.02 Aacs NM_023104 -0.13 1.98E-14 Aamp ENSRNOT00000019497 -0.04 0.02 Aars ENSRNOT00000025052 0.05 8.99E-03 Abcb8 NM_001007796 -0.11 1.55E-04 Abce1 ENSRNOT00000024753 0.06 9.34E-03 Abcf1 CK359266 0.12 3.01E-04 Abhd10 ENSRNOT00000048533 0.06 0.02 Abhd12 NM_001024314 0.05 0.04 Abhd13 CX570069 0.07 5.80E-03 Abhd3 ENSRNOT00000041878 0.07 0.01 Abhd7 ENSRNOT00000037101 0.14 5.12E-05 Abi2 NM_173143 -0.21 3.13E-09 Abl1 ENSRNOT00000042495 -0.1 5.04E-03 Abr ENSRNOT00000032861 -0.23 1.09E-05 Abt1 ENSRNOT00000023649 0.06 5.57E-03 Acad9 BF406274 -0.14 6.72E-04 Acd NM_001037193 0.06 0.02 Acly EV776653 -0.11 3.79E-11 Acot3 ENSRNOT00000051235 0.07 0.05 Acp2 NM_016988 0.07 0.01 Acsl3 NM_057107 -0.05 0.03 Acsl4 NM_053623 -0.33 5.22E-31 Actb NM_031144 -0.04 0.05 Actn1 NM_031005 -0.1 0.03 Actr2 702598971T1 -0.4 3.83E-03 Actr3b ENSRNOT00000050686 -0.2 9.29E-04 Actr5 ENSRNOT00000041276 0.06 1.82E-03 Actr6 XM_001076791 -0.3 1.13E-30 Actr8 ENSRNOT00000020750 -0.1 6.53E-07 Acyp1 ENSRNOT00000009086 0.06 9.73E-03 Acyp2 ENSRNOT00000037897 -0.08 0.04 Adcy6 NM_012821 -0.12 1.26E-04 Add3 AI029424 -0.14 0.02 Adfp CO574727 -0.11 1.94E-03 Ado ENSRNOT00000000791 0.05 6.92E-03 Adrbk2 NM_012897 -0.08 8.42E-03 Aff4 CF115443 0.21 5.95E-03 Agl ENSRNOT00000021786 -0.06 0.04 Agpat2 ENSRNOT00000026408 0.07 7.47E-03 Agpat3 703889388J1 0.16 0.02 Agtrap DY562938 0.08 0.05 Ahctf1 ENSRNOT00000035875 -0.04 0.02 Aifm1 NM_031356 0.08 4.01E-07 Page 47 of 288 Diabetes

Aifm2 ENSRNOT00000035982 0.15 4.89E-04 Aig1 AI231309 -0.18 3.94E-08 Akap10_predicted ENSRNOT00000003871 -0.17 1.08E-11 Akp3 NM_022680 0.07 0.03 Aldh1l2 g3291417 -0.19 3.44E-08 Alg11 ENSRNOT00000017164 0.06 6.08E-05 Alg14 NM_001014176 -0.05 6.15E-03 Alg5 NM_001025407 0.06 0.03 Alkbh3 NM_001014180 0.05 9.95E-03 Alkbh5 CA504904 0.07 0.02 Alkbh7 XM_001053732 -0.07 4.63E-03 Als2 XM_001061827 -0.05 1.01E-03 Als2cr4 ENSRNOT00000031858 0.05 0.04 Amhr2 NM_030998 0.08 0.01 Amn AI103368 0.07 1.38E-03 Anapc7 XM_001079480 -0.1 4.48E-04 Angel1 ENSRNOT00000014635 0.1 0.02 Angel2 ENSRNOT00000005084 -0.05 0.04 Angptl4 NM_199115 0.06 0.04 Ankmy2 ENSRNOT00000007562 0.05 0.03 Ankrd10 CO566009 -0.05 0.02 Ankrd28 BM385717 0.04 6.03E-03 Ankrd52 ENSRNOT00000047462 -0.11 0.04 Ankrd57 DY318217 0.1 0.05 Ankrd9 NM_001012112 0.12 7.98E-04 Anp32a CB696160 -0.31 3.43E-07 Anxa4 NM_024155 -0.28 1.42E-07 Ap1g1 ENSRNOT00000051859 0.06 0.01 Apaf1 NM_023979 -0.11 4.50E-03 Apc g4465574 0.06 0.01 Apc2 ENSRNOT00000049146 -0.06 0.05 Api5 DQ480749 -0.1 1.25E-03 Appbp2 g11659913 -0.24 2.66E-18 Appl2 ENSRNOT00000010986 -0.07 0.04 Aptx NM_148889 -0.09 2.46E-03 Araf NM_001033663 -0.1 1.18E-07 Arfrp1 NM_053980 -0.07 3.90E-03 Arhgap24 NM_001012032 0.07 0.04 Arhgap29 704257309J1 -0.12 0.04 Arhgap5 NM_001047869 0.11 1.08E-03 Arhgef11 704289575J1 -0.1 3.40E-03 Arhgef12 703861224J1 -0.12 0.05 Arhgef17 XM_001067343 -0.05 0.02 Arhgef9 NM_023957 -0.24 8.09E-07 Arid3b ENSRNOT00000026736 0.07 8.65E-03 Arid4b NM_053421 -0.2 1.05E-07 Arih1 703829854J1 -0.12 8.82E-05 Diabetes Page 48 of 288

Arih2 EV774720 0.08 2.68E-03 Arl4a NM_019186 0.05 0.04 Arl6ip2 BC092650 0.04 0.04 Arl8b NM_001024332 0.05 0.01 Armc1 ENSRNOT00000018548 -0.06 2.77E-04 Armc10 BC079464 -0.13 5.49E-06 Armc9 ENSRNOT00000050006 -0.15 0.03 Armcx2 NM_001014274 0.07 0.02 Arpc1b NM_019289 0.05 1.86E-03 Arpc4 XM_001078712 -0.04 0.03 Arpc5 NM_001025717 -0.06 5.45E-03 Asf1b ENSRNOT00000006964 0.07 3.22E-03 Atad3a NM_001034922 0.06 7.62E-03 Atad5 g8508223 0.1 1.72E-03 Atf7 ENSRNOT00000020527 0.1 4.58E-04 Atg12 NM_001038495 -0.15 6.76E-08 Atox1 NM_053359 -0.08 5.03E-06 Atp1b3 NM_012913 0.04 0.04 Atp2a2 ENSRNOT00000024347 0.06 0.04 Atp5g3 NM_053756 -0.04 0.03 Atp6v1a1 ENSRNOT00000002727 -0.1 0.02 Atp6v1b2 BP492200 -0.23 1.50E-05 Atp9b ENSRNOT00000041380 -0.09 4.46E-07 Atpbd1c NM_201991 0.06 0.05 Atrnl1 ENSRNOT00000023414 -0.13 0.02 Atrx ENSRNOT00000042751 0.09 1.04E-04 Atxn2 BC091406 0.05 0.02 Atxn3 NM_021702 -0.12 8.63E-05 Atxn7 ENSRNOT00000010103 -0.14 1.22E-03 Auh ENSRNOT00000015786 -0.05 0.03 Aurka ENSRNOT00000006323 -0.19 6.37E-17 Aurkb NM_053749 0.07 1.80E-04 Avpi1 NM_134373 0.09 9.13E-03 Azi2 703920131J1 0.08 0.03 Azin1 NM_022585 -0.1 3.55E-06 B3gnt6 ENSRNOT00000046850 0.07 1.34E-03 B4galnt1 NM_022860 0.1 0.02 B4galt1 CV106690 0.07 1.55E-03 B4galt3 NM_001009539 -0.23 2.51E-18 B4galt6 NM_031740 -0.23 5.90E-14 Bag5 NM_001008526 0.05 0.02 Baiap2l1 NM_001034140 0.06 0.01 Bak1 NM_053812 0.14 0.04 Batf3 NM_021865 0.06 0.04 Baz2a g13270342 -0.09 6.21E-03 Bbs4 ENSRNOT00000031262 0.09 1.15E-03 Bcas2 ENSRNOT00000025592 -0.49 0 Page 49 of 288 Diabetes

Bckdk BQ782172 -0.14 2.08E-16 Bdh1 NM_053995 0.1 2.29E-06 Bdp1 700697237F6 -0.25 0.01 Becn1 NM_053739 -0.05 0.02 Bet1 BQ193891 -0.23 6.28E-05 Bfar NM_001013125 -0.12 1.78E-07 Bhlhb2 NM_053328 -0.13 5.88E-04 Bhlhb8 NM_012863 0.13 3.71E-03 Bicd2 NM_001033674 -0.14 8.47E-03 Blcap NM_133582 0.06 0.05 Bles03 NM_001024233 0.12 2.20E-03 Blmh NM_001034163 0.07 1.40E-04 Bloc1s1 ENSRNOT00000010380 -0.07 0.04 Bloc1s2 NM_001037349 -0.07 1.27E-05 Bmp2 NM_017178 0.22 8.37E-03 Bmp8a ENSRNOT00000045922 0.11 3.78E-03 Bnc2 ENSRNOT00000051758 0.05 0.03 Bnip2 BF282292 -0.22 2.21E-08 Bok ENSRNOT00000024526 -0.07 1.81E-03 Bpgm EV764831 0.04 0.03 Brca1 NM_012514 -0.05 0.02 Bri3 NM_001009604 -0.32 5.79E-29 Brms1 XM_001072516 0.13 8.69E-03 Brpf1 BQ196163 0.05 0.02 Brwd3 ENSRNOT00000057432 -0.13 3.09E-03 Btaf1 ENSRNOT00000054751 0.07 0.03 Btbd10 NM_001014022 0.08 6.68E-03 Btbd3 ENSRNOT00000010835 0.08 0.04 Btbd7 ENSRNOT00000011518 -0.07 0.02 Btg2 BI278296 -0.3 1.42E-06 Btg3 NM_019290 0.06 1.31E-03 Bxdc2 NM_001029915 0.04 0.03 Bysl NM_182674 0.05 3.51E-03 C8b ENSRNOT00000010100 -0.05 0.04 Ca2 NM_019291 0.08 0.04 Cables2 ENSRNOT00000008279 -0.07 4.78E-03 Cacna1c ENSRNOT00000009343 0.05 0.04 Cacna1i NM_020084 -0.05 0.03 Cacna2d1 NM_012919 -0.09 1.21E-03 Cacnb2 NM_053851 -0.1 1.15E-03 Cadps NM_013219 -0.08 2.38E-07 Calm2 NM_017326 -0.16 8.11E-04 Calu NM_001033898 -0.14 1.24E-03 Camk2b ENSRNOT00000005359 -0.06 0.04 Camk2n2 BP468561 0.1 2.44E-03 Canx DY471480 -0.04 3.72E-03 Casp7 NM_022260 0.09 0.03 Diabetes Page 50 of 288

Cbfb CA945838 0.09 0.03 Cbx1 ENSRNOT00000011665 -0.25 6.10E-03 Ccdc115 ENSRNOT00000017722 0.08 3.86E-03 Ccdc117 CF112977 -0.11 0.02 Ccdc124 ENSRNOT00000025626 0.05 0.04 Ccdc126 ENSRNOT00000012490 -0.06 0.03 Ccdc23 NM_001038992 0.06 0.03 Ccdc34 ENSRNOT00000008753 0.07 0.04 Ccdc41 AI031052 0.07 0.01 Ccdc43 ENSRNOT00000003685 0.06 0.04 Ccdc49 AI317837 0.06 0.03 Ccdc85a ENSRNOT00000004515 0.09 0.03 Ccdc85b ENSRNOT00000027896 0.08 0.02 Ccdc94 BC129098 0.07 7.29E-03 Ccdc97 AW917236 -0.06 0.03 Ccl17 NM_057151 0.06 0.05 Ccna2 NM_053702 0.09 6.96E-07 Ccnb2 NM_001009470 0.07 1.93E-03 Ccnd2 BQ208735 0.17 0.01 Ccnd3 NM_012766 0.14 0.04 Ccng1 BQ191504 -0.11 0.04 Ccni CO571802 -0.1 9.89E-06 Ccnj XM_001057184 0.09 0.05 Ccpg1 ENSRNOT00000039176 -0.06 3.09E-03 Ccr9 NM_172329 -0.04 0.02 Cd164 NM_031812 -0.06 5.75E-03 Cd1d1 NM_017079 -0.15 4.97E-05 Cd2 NM_012830 0.07 0.03 Cd200 NM_031518 0.11 8.26E-10 Cd276 NM_182824 0.07 7.33E-03 Cd82 NM_031797 0.06 0.04 Cd99l2 NM_134459 0.04 0.05 Cdan1 ENSRNOT00000014664 0.09 1.83E-03 Cdc23 ENSRNOT00000037888 0.07 7.41E-03 Cdc25b NM_133572 0.08 0.05 Cdc2a NM_019296 -0.26 1.30E-30 Cdc34 NM_001013103 0.09 1.51E-04 Cdc37l1 NM_001011941 -0.15 9.25E-10 Cdc40 ENSRNOT00000000709 -0.25 3.85E-12 Cdc42ep4 ENSRNOT00000048264 -0.18 5.13E-05 Cdc7 ENSRNOT00000002875 -0.05 0.04 Cdca3 NM_001007648 0.04 2.11E-03 Cdh1 NM_031334 -0.07 0.03 Cdipt NM_138899 0.05 0.03 Cdkn1a DN947728 -0.25 0.04 Cdkn2aipnl NM_001008278 0.04 8.56E-03 Cdo1 NM_052809 0.09 0.05 Page 51 of 288 Diabetes

Cdon NM_017358 -0.07 0.02 Cds1 NM_031242 -0.11 5.88E-03 Ceacam20 ENSRNOT00000026060 0.11 0.03 Cebpg 703848448J1 -0.14 0.02 Cebpz ENSRNOT00000006824 -0.1 0.05 Cenpa ENSRNOT00000012512 -0.06 0.02 Cenpi NM_012955 0.09 1.99E-04 Cenpn ENSRNOT00000058752 -0.07 0.03 Centa1 NM_133567 0.11 0.02 Centd1 ENSRNOT00000003014 0.1 0.03 Centg1 BF544947 0.09 0.05 Centg2 XM_237381 0.06 0.01 Cep55 NM_001025646 0.05 0.05 Cep68 ENSRNOT00000039523 0.1 6.71E-03 Cep70 NM_001017470 -0.07 0.04 Cerk ENSRNOT00000022882 -0.12 1.02E-03 Cetn3 ENSRNOT00000021735 -0.08 9.66E-03 Cfl2 XM_001079054 0.09 1.01E-04 Cgi-96 ENSRNOT00000034983 0.06 1.57E-03 Cgrrf1 NM_053899 0.06 0.02 Chaf1b NM_001024741 0.05 0.04 Chchd1 ENSRNOT00000012372 0.03 7.60E-03 Chchd3 XM_238346 0.06 0.05 Chd4 CB322822 0.09 1.04E-06 Chd6 ENSRNOT00000022861 -0.11 6.69E-08 Chek1 NM_080400 0.06 0.02 Chid1 NM_001047854 -0.07 0.02 Chm NM_017067 -0.24 7.52E-04 Chmp2b XM_001063932 -0.06 0.01 Chmp6 BC070963 0.06 2.75E-03 Chrnb2 NM_019297 0.08 0.02 Chst10 NM_080397 0.06 0.02 Ciao1 NM_001008766 0.03 0.03 Ciapin1 NM_001007689 0.06 2.24E-04 Cirbp NM_031147 -0.17 1.29E-06 Cirh1a NM_001009640 0.07 1.08E-06 Cisd1 ENSRNOT00000000749 0.04 7.59E-03 Ckap4 BQ208856 0.2 2.49E-04 Cldn14 NM_001013429 0.08 0.02 Cldn4 NM_001012022 -0.07 0.04 Clec12b ENSRNOT00000055846 -0.1 0.04 Clic4 703022269H1 0.06 1.08E-03 Clip1 DY319638 0.22 2.46E-03 Clp1 NM_001009599 0.06 0.03 Clstn1 ENSRNOT00000045063 0.05 2.82E-03 Cmtm4 702082415F6 -0.15 2.78E-03 Cnih ENSRNOT00000013331 -0.1 1.80E-07 Diabetes Page 52 of 288

Cnn3 NM_019359 0.06 7.43E-03 Cno 704149177J1 -0.17 4.16E-18 Cnot6 704227082H1 -0.22 4.05E-05 Cnot7 ENSRNOT00000016882 -0.06 4.61E-03 Cntn3 NM_019329 -0.11 0.04 Cobl XM_001053778 0.06 0.05 Cobll1 ENSRNOT00000001606 0.05 0.03 Col4a3bp ENSRNOT00000021549 -0.27 2.15E-03 Commd8 XM_001069497 0.13 4.15E-04 Commd9 NM_001033692 0.04 7.99E-03 Cops2 NM_153297 0.08 3.48E-03 Cops7b XM_343614 0.05 8.28E-03 Cops8 NM_001013227 0.05 0.01 Coq3 NM_019187 0.14 5.14E-06 Coq5 NM_001039022 0.06 0.01 Coro1a NM_130411 0.08 1.29E-04 Cotl1 ENSRNOT00000021954 0.1 0.03 Cpeb4 g8499269 0.05 0.02 Cplx1 NM_022864 0.09 5.77E-05 Cpne3 704208022H1 -0.19 0.02 Cpne8 XM_001056316 -0.09 6.86E-03 Cpox BP504112 0.15 6.99E-07 Cpsf5 NM_001039004 -0.06 0.03 Cpsf6 CB746234 -0.21 0.05 Crb3 NM_001025661 0.07 9.22E-03 Crcp BF397860 0.04 3.55E-03 Crebl2 NM_001015027 -0.11 0.02 Creg1 BF282301 0.09 6.24E-03 Crem NM_013086 0.21 1.97E-06 Crhr1 NM_030999 -0.09 6.90E-06 Crlf1 ENSRNOT00000060097 0.07 7.14E-03 Crnkl1 NM_053797 0.05 5.33E-03 Crot NM_031987 0.15 1.79E-04 Csde1 NM_054006 -0.1 4.88E-05 Csgalnact1 XM_001070654 0.07 0.05 Csnk1d NM_139060 -0.11 1.05E-03 Csnk2a2 703916024J1 -0.12 9.91E-03 Cspg5 NM_133652 -0.13 0.02 Csrp1 NM_017148 -0.17 1.32E-10 Csrp2bp 703914142J1 0.06 2.76E-03 Ctage5 ENSRNOT00000006995 0.06 0.03 Ctbp1 BC078778 -0.08 6.77E-03 Ctdsp1 BC105903 0.09 0.04 Ctnnbip1 ENSRNOT00000055562 0.1 1.61E-05 Ctps ENSRNOT00000013899 -0.04 0.05 Cttn NM_021868 0.04 0.03 Cul4b XM_001058651 -0.08 6.48E-03 Page 53 of 288 Diabetes

Cx3cl1 NM_134455 0.09 0.03 Cxcl11 NM_182952 -0.16 3.92E-08 Cxcl17 ENSRNOT00000057433 0.08 0.02 Cxcr7 NM_053352 -0.11 2.39E-04 Cyb561d1 ENSRNOT00000040396 0.14 9.96E-05 Cyb5r4 ENSRNOT00000013975 -0.06 0.04 Cyc1 ENSRNOT00000017067 0.04 4.80E-03 Cyld ENSRNOT00000060789 -0.23 1.15E-19 Daam1 ENSRNOT00000005927 -0.26 6.96E-08 Dab2ip NM_138710 -0.09 0.02 Dag1 g14932497 -0.07 0.04 Daglb ENSRNOT00000001437 0.06 0.04 Dazap2 NM_001013107 -0.44 5.48E-34 Dbndd1 NM_001014156 0.04 0.02 Dbp NM_012543 -0.03 0.02 Dbt ENSRNOT00000020267 0.11 1.38E-03 Dcakd NM_001007724 0.06 6.60E-03 Dcbld1 ENSRNOT00000000462 0.13 0.03 Dclk1 NM_053343 -0.13 1.02E-06 Dclre1b NM_001025687 -0.07 7.76E-03 Dcp2 ENSRNOT00000015645 0.11 0.05 Dd25 NM_199403 0.09 0.03 Ddx1 NM_053414 0.04 0.02 Ddx24 NM_199119 -0.04 0.04 Ddx25 NM_031630 -0.03 0.03 Ddx28 g8505130 0.09 0.03 Ddx3x BC085914 0.05 3.03E-03 Ddx46 BE109072 0.23 2.89E-06 Ddx56 NM_001004211 0.05 2.97E-03 Dedd NM_031800 -0.07 0.01 Def8 NM_001024774 -0.2 1.77E-07 Degs1 NM_053323 -0.16 2.56E-10 Dek NM_001004255 -0.1 1.23E-06 Dennd1b ENSRNOT00000043907 -0.43 3.82E-22 Depdc1a XM_001080406 0.08 9.37E-06 Det1 NM_001037194 0.05 0.03 Dffa NM_053679 0.09 5.89E-04 Dgcr8 XM_001064513 -0.1 9.47E-03 Dguok ENSRNOT00000015526 -0.1 3.89E-03 Dhcr24 ENSRNOT00000009402 -0.11 1.49E-10 Dhx37 ENSRNOT00000030823 -0.15 1.43E-04 Dhx9 ENSRNOT00000003707 -0.05 0.02 Dixdc1 NM_001037654 -0.26 5.60E-09 Dld NM_199385 0.04 0.02 Dmbx1 ENSRNOT00000014626 0.07 0.04 Dnaja1 NM_022934 -0.07 0.01 Dnaja2 704234672J1 -0.16 0.01 Diabetes Page 54 of 288

Dnajb1 CB718513 0.06 9.47E-03 Dnajb13 NM_001005885 -0.06 0.03 Dnajc10 BC100105 -0.11 2.51E-04 Dnajc15 ENSRNOT00000012530 0.05 3.51E-03 Dnajc3 NM_022232 0.06 0.03 Dnajc9 ENSRNOT00000009009 0.05 0.02 Dnase2a NM_138539 0.04 0.05 Dnm3 g4256116 0.11 4.46E-03 Dnmbp XM_001060754 0.07 0.01 Dnmt1 CA506965 -0.13 1.95E-07 Dock9 X68101 -0.07 2.56E-03 Dohh NM_001025006 0.06 4.17E-03 Dpep3 NM_001008383 0.13 5.53E-03 Dpf2 ENSRNOT00000028363 -0.08 9.28E-03 Dph4 XM_342483 0.08 0.04 Dpysl3 NM_012934 -0.21 1.92E-06 Dtx3l DY471775 0.11 0.03 Duoxa1 ENSRNOT00000024245 -0.07 0.04 Dusp11 NM_001025650 -0.16 6.09E-07 Dusp12 NM_022248 -0.11 3.00E-03 Dusp19 ENSRNOT00000012290 0.06 0.04 Dusp22 ENSRNOT00000024587 -0.06 3.05E-03 Dut CX570340 -0.09 0.01 Dync1i1 NM_019234 0.06 0.03 Dynll2 CB322978 -0.09 7.95E-03 Dynlrb2 ENSRNOT00000016713 -0.13 7.35E-03 Dyrk2 ENSRNOT00000010283 -0.08 0.04 Dyrk3 NM_001024767 0.08 0.02 Dyt1 NM_153303 -0.04 0.04 Dzip1 BQ208855 0.09 0.05 ENSRNOT00000014361 -0.15 1.24E-04 Ebna1bp2 NM_001008721 0.05 0.01 Echs1 NM_078623 -0.05 4.17E-03 Ecsit NM_001006986 0.05 5.41E-03 Edem2 NM_001004230 -0.11 6.21E-04 Eed ENSRNOT00000024082 0.07 8.21E-03 Eef1a1 DV723221 -0.11 3.72E-06 Eef1d NM_001013104 0.03 0.05 Eef1e1 CF977307 -0.07 0.04 Efhd1 ENSRNOT00000021168 0.1 0.02 Efhd2 NM_001031648 0.09 3.68E-05 Ehbp1 ENSRNOT00000012131 -0.1 5.03E-04 Eid1 XM_001077667 -0.08 1.03E-04 Eif1ad CA504590 0.06 0.02 Eif2ak1 NM_013223 0.05 0.02 Eif2ak3 NM_031599 -0.11 0.03 Eif2b1 NM_172029 0.05 7.21E-04 Page 55 of 288 Diabetes

Eif2b2 NM_032058 0.05 3.89E-03 Eif2b4 NM_053950 0.05 2.66E-03 Eif2b5 U19516 0.08 1.49E-04 Eif2c1 ENSRNOT00000037728 -0.1 8.40E-03 Eif3g NM_001013095 0.04 3.77E-03 Eif3h NM_198751 -0.07 4.07E-03 Eif3s10 NM_001047087 0.05 0.05 Eif4a1 CB586414 -0.1 0.02 Eif4a2 NM_001008335 -0.04 0.04 Eif4h NM_001006957 0.06 1.53E-04 Eif5a2 ENSRNOT00000015779 -0.16 6.67E-03 Eif6 NM_001037352 0.06 2.32E-03 Elf1 NM_053520 -0.12 0.03 Elf2 NM_001033909 -0.06 0.04 Elk4 704232218H1 -0.13 2.45E-03 Elovl4 XM_001062735 0.09 7.23E-03 Elovl5 NM_134382 -0.15 0.03 Elovl6 NM_134383 0.07 5.35E-03 Elovl7 XM_342192 0.07 5.51E-03 Emd NM_012948 0.06 4.22E-03 Eml4 AA899923 -0.2 1.65E-04 Eml5 ENSRNOT00000005978 -0.08 7.05E-03 Enah AW918724 0.15 0.03 Enc1 DQ282125 -0.21 1.30E-03 Enoph1 NM_001009391 0.04 0.02 Enpp5 NM_001012744 0.06 0.01 Entpd3 NM_178106 0.04 0.04 Entpd6 NM_053498 0.07 5.01E-03 Epb4.1 g18184498 -0.08 0.03 Epb4.1l3 ENSRNOT00000022878 0.09 0.02 Epn2 NM_021852 -0.22 4.83E-35 Eps8 703959071J1 -0.15 3.52E-12 Ercc8 ENSRNOT00000013598 0.04 7.39E-03 Erich1 XM_001075018 0.05 5.03E-03 Erlin1 ENSRNOT00000017268 0.12 0.05 Ero1l BC071175 0.14 5.69E-05 Ero1lb ENSRNOT00000003526 -0.33 3.58E-03 Etnk1 BC089927 -0.2 2.73E-19 Etv1 ENSRNOT00000008990 -0.25 3.45E-06 Evi1 XM_226987 -0.05 0.03 Exo1 ENSRNOT00000005314 0.06 0.01 Exoc5 NM_022204 -0.13 3.59E-03 Exoc7 NM_022691 0.05 0.05 Exosc9 NM_001025406 0.05 0.04 Extl1 ENSRNOT00000022522 0.15 5.86E-03 Extl2 CK471418 0.09 0.03 Extl3 NM_020097 -0.22 1.28E-20 Diabetes Page 56 of 288

F11r NM_053796 -0.19 4.14E-09 F2r NM_012950 0.06 3.08E-03 F3 NM_013057 -0.16 1.86E-04 F5 XM_001075221 -0.09 0.05 Fam101b NM_001007611 0.07 0.01 Fam107b NM_001025034 -0.29 4.90E-13 Fam108a1 NM_001006983 0.07 0.04 Fam122a NM_001014029 0.05 0.03 Fam128b ENSRNOT00000002511 0.06 9.92E-04 Fam152a AW913871 -0.08 3.97E-03 Fam152b BE112735 0.08 5.00E-04 Fam19a3 ENSRNOT00000040772 0.09 4.27E-03 Fam19a5 BQ782870 0.09 0.02 Fam20b g4252561 -0.16 1.29E-06 Fam32a CB612797 -0.07 0.03 Fam44b NM_001013854 0.06 0.04 Fam45a AW525101 0.08 9.11E-04 Fam46b ENSRNOT00000010487 0.06 3.76E-03 Fam49a CK842097 0.17 5.03E-03 Fam54b NM_001013935 0.07 1.24E-04 Fam58b NM_001025412 0.08 2.09E-03 Fam64a ENSRNOT00000010975 0.06 6.22E-03 Fam69a ENSRNOT00000030479 0.12 1.44E-03 Fam92a1 ENSRNOT00000022249 0.05 5.31E-03 Fam98a CO382388 0.11 0.02 Fbl NM_001025643 -0.07 0.01 Fbxl11 CK364811 0.17 0.05 Fbxl5 ENSRNOT00000007016 -0.12 3.87E-03 Fbxo16 NM_001013132 0.04 0.01 Fbxo22 NM_001037770 -0.13 1.75E-05 Fbxw11 ENSRNOT00000005874 -0.23 1.03E-09 Fech ENSRNOT00000059188 0.07 6.10E-03 Fem1c ENSRNOT00000004784 -0.1 7.70E-03 Fen1 NM_053430 0.05 1.35E-03 Fermt2 NM_001011915 -0.13 5.19E-05 Ffar1 NM_153304 -0.15 0.02 Fgfr1op2 NM_201421 0.08 1.09E-03 Fgfr3 NM_053429 -0.1 0.01 Fgl2 NM_053455 -0.27 1.37E-03 Fis1 ENSRNOT00000001924 -0.05 0.05 Fjx1 ENSRNOT00000007077 0.12 1.17E-03 Fkbp2 ENSRNOT00000028725 -0.15 2.39E-10 Fkrp NM_001025678 0.11 8.14E-07 Fnbp1l NM_001039609 -0.21 5.73E-04 Fndc3a ENSRNOT00000020135 -0.06 0.03 Fndc3b ENSRNOT00000034096 0.05 4.86E-03 Foxd4 g4399037 0.06 0.05 Page 57 of 288 Diabetes

Foxo3a ENSRNOT00000000327 -0.11 0.01 Fto g5016731 0.04 0.04 Fts NM_001011926 -0.07 1.52E-03 Ftsj3 NM_001012014 0.04 0.05 Fubp3 703973695J1 -0.05 0.05 Fusip1 NM_001025738 -0.19 4.19E-04 Fut11 NM_173308 -0.1 0.03 Fut4 NM_022219 0.08 0.02 Fxn ENSRNOT00000020412 0.04 0.02 Fxr1 NM_001012179 -0.05 0.02 Fyb ENSRNOT00000018634 0.08 0.04 Fyco1 ENSRNOT00000008630 0.1 0.02 Fyttd1 XM_001081958 -0.2 2.01E-15 G0s2 NM_001009632 -0.28 7.35E-04 G3bp1 704304832H1 -0.06 3.19E-05 G7c AW527641 0.08 0.05 Gabarapl2 NM_022706 0.07 0.04 Gabra4 NM_080587 0.08 0.04 Gabrd NM_017289 0.18 9.97E-03 Galnt1 ENSRNOT00000022117 -0.07 3.00E-03 Galnt12 ENSRNOT00000011112 0.13 0.01 Galnt7 BF397407 0.14 4.17E-04 Gap43 NM_017195 0.04 4.66E-03 Gapvd1 ENSRNOT00000024599 -0.07 0.02 Gars ENSRNOT00000014780 0.04 0.01 Gatad1 ENSRNOT00000061122 0.05 0.03 Gatm NM_031031 0.11 1.18E-04 Gba2 ENSRNOT00000022002 0.1 3.83E-04 Gbf1 CK226550 0.21 3.82E-04 Gda NM_031776 0.08 0.05 Gemin4 XM_001080744 0.07 0.02 Gemin6 NM_001009466 0.08 5.10E-03 Gfm2 BC091392 -0.13 2.01E-06 Git2 CV797035 -0.07 0.02 Gjd2 NM_019281 -0.09 0.01 Glipr1 NM_001011987 -0.11 0.01 Glis2 ENSRNOT00000006680 -0.07 0.01 Glrx2 ENSRNOT00000004558 -0.21 2.50E-08 Glrx5 ENSRNOT00000005781 0.03 0.02 Gls BQ779765 -0.16 0.03 Glt8d3 AY623033 -0.07 7.31E-03 Glul NM_017073 -0.06 2.17E-06 Gmcl1 NM_001033931 0.08 7.89E-04 Gmip ENSRNOT00000039607 -0.13 0.01 Gna11 NM_031033 0.13 0.03 Gna14 NM_001013151 0.13 2.04E-04 Gnai1 DV713743 0.04 0.03 Diabetes Page 58 of 288

Gnat1 ENSRNOT00000023791 0.1 0.01 Gnb1 ENSRNOT00000022649 -0.15 0.02 Gnb5 NM_031770 -0.13 2.53E-03 Gnl2 NM_001025736 0.06 0.02 Gnptg ENSRNOT00000029674 0.05 0.03 Gns ENSRNOT00000006566 0.04 0.04 Golim4 ENSRNOT00000037115 0.06 0.03 Gosr1 NM_053584 -0.04 0.01 Gosr2 NM_031685 -0.06 5.95E-04 Got1 NM_012571 0.04 0.02 Got2 NM_013177 0.03 0.03 Gpbp1 ENSRNOT00000036658 0.06 0.02 Gpd2 ENSRNOT00000042944 -0.26 1.26E-03 Gpm6a CB782138 0.07 0.04 Gpr137b AI180008 0.1 2.92E-03 Gpr180 NM_001006994 0.09 2.28E-06 Gpr27 NM_023099 -0.23 8.65E-05 Gpr56 NM_152242 -0.13 2.25E-03 Gpr85 NM_022254 -0.09 0.05 Gprasp2 ENSRNOT00000004260 0.05 0.01 Gpsm2 ENSRNOT00000016250 0.07 8.77E-03 Gramd3 BI281497 0.09 3.86E-03 Grb14 NM_031623 0.09 9.64E-04 Gria4 BC093608 0.12 8.69E-03 Grin1 NM_017010 0.09 2.84E-03 Grk5 CK479407 0.08 0.04 Gspt2 XM_001057027 0.1 1.38E-11 Gsr NM_053906 -0.08 7.84E-05 Gtdc1 CN542765 -0.1 0.05 Gtf2e2 XM_224929 0.03 0.02 Gtf2f1 NM_001007711 0.04 0.01 Gtf2h5 ENSRNOT00000024211 -0.09 3.24E-03 Gtf3c3 ENSRNOT00000002864 -0.08 0.01 Gtf3c4 CB583374 0.06 0.03 Gtl3 NM_001037978 0.05 0.01 Gucy1b3 NM_012769 0.07 1.67E-03 Gusb NM_017015 -0.1 5.82E-03 Gyltl1b NM_199107 0.12 3.01E-05 H1foo ENSRNOT00000042673 -0.09 0.03 H2afx ENSRNOT00000059715 0.11 3.78E-03 H2afz NM_022674 -0.21 4.98E-10 Habp4 NM_001079940 0.14 1.03E-05 Hao1 ENSRNOT00000006330 -0.06 0.02 Hbegf NM_012945 -0.2 6.23E-04 Hbs1l NM_001011934 -0.06 4.79E-03 Hdac3 NM_053448 -0.1 1.13E-04 Hdac8 XM_001070606 0.07 6.81E-03 Page 59 of 288 Diabetes

Hdhd2 704354283J1 -0.27 1.10E-03 Heatr5a ENSRNOT00000035309 -0.09 0.04 Heatr5b ENSRNOT00000035905 -0.18 9.99E-23 Hiat1 ENSRNOT00000020907 -0.05 0.03 Hiatl1 XM_001060279 -0.09 6.76E-04 Hibadh NM_022243 -0.15 1.94E-07 Hint3 g11371243 0.09 5.00E-03 Hirip3 NM_001025725 0.04 0.04 Hist2h4_predicted ENSRNOT00000040210 0.1 0.01 Hlx NM_001077674 -0.05 0.03 Hmcn1 ENSRNOT00000030951 0.08 0.03 Hmg20a ENSRNOT00000022976 0.1 0.03 Hmga1 X62875 0.16 0.01 Hmgb2l1 ENSRNOT00000018692 -0.13 9.93E-03 Hmgb3 ENSRNOT00000015044 -0.18 2.33E-05 Hmgcs1 NM_017268 -0.1 4.35E-03 Hn1 CK603822 -0.06 4.45E-03 Hn1l NM_001013182 0.05 9.71E-04 Hnrnpr NM_175603 -0.06 6.16E-05 Hnrnpu NM_057139 -0.11 1.45E-03 Hnrpa3 NM_198132 0.03 0.04 Hnrpf NM_001037287 0.03 0.05 Hnrpm NM_053876 -0.08 2.83E-06 Homer1 NM_031707 -0.08 0.05 Homez NM_152849 -0.14 1.60E-03 Hook1 ENSRNOT00000012396 -0.17 4.21E-05 Hoxa10 ENSRNOT00000036394 0.11 2.93E-04 Hrasls3 NM_017060 0.12 7.98E-03 Hsbp1 CF975977 -0.21 1.71E-11 Hsdl2 NM_001025697 -0.09 6.14E-04 Hspa2 NM_021863 0.09 6.31E-04 Hspa4 NM_153629 -0.09 0.04 Hspa4l ENSRNOT00000015474 -0.1 3.37E-04 Hspb1 NM_031970 -0.11 0.05 Htr5b ENSRNOT00000003441 0.1 0.04 Htr6 NM_024365 0.07 0.04 Ick NM_138886 -0.05 6.84E-03 Id2 ENSRNOT00000009491 -0.12 0.03 Idh2 NM_001014161 0.04 0.03 Idh3B NM_053581 -0.04 0.01 Idi1 NM_053539 -0.2 2.42E-25 Ifih1 ENSRNOT00000009620 0.1 0.01 Ifit1 NM_020096 -0.06 0.04 Ifitm1 ENSRNOT00000005645 -0.09 0.02 Ifna4 ENSRNOT00000046207 0.07 2.31E-03 Ifngr1 NM_053783 0.05 0.04 Ifngr2 AI598699 0.08 0.03 Diabetes Page 60 of 288

Ifrd1 NM_019242 0.06 1.27E-04 Ift122 ENSRNOT00000014733 -0.1 3.06E-04 Ift74 NM_001007001 -0.11 5.69E-03 Igfbp5 ENSRNOT00000023530 0.09 1.37E-03 Il11 BP489016 -0.14 0.03 Il18rap NM_184047 0.11 0.05 Il20ra ENSRNOT00000050656 -0.08 0.02 Il8ra NM_019310 0.11 2.60E-03 Imp3 ENSRNOT00000023456 -0.24 7.02E-14 Imp4 NM_001009700 0.05 7.02E-03 Impa1 NM_032057 0.06 2.31E-03 Incenp ENSRNOT00000043387 0.09 0.05 Ing4 ENSRNOT00000024116 -0.11 3.49E-08 Inpp4a NM_031002 -0.1 0.02 Ints9 ENSRNOT00000018071 0.06 0.02 Invs ENSRNOT00000011622 -0.1 0.01 Ipmk BE113834 -0.13 7.56E-04 Ipo11 BC092638 0.07 4.11E-03 Ippk NM_001008556 -0.12 2.09E-04 Iqcb1 ENSRNOT00000003223 0.07 0.03 Iqgap1 ENSRNOT00000018021 -0.19 1.77E-07 Irak4 ENSRNOT00000007932 -0.09 5.85E-03 Ireb2 703887365J1 -0.09 1.49E-03 Irf5 ENSRNOT00000010001 0.09 0.03 Isca1 NM_181626 -0.1 5.90E-13 Isl1 AI029166 -0.18 0.04 Isoc1 NM_001014242 -0.13 1.49E-04 Isy1 NM_001014188 -0.05 3.74E-03 Itch NM_001005887 -0.15 5.24E-04 Itga11 g11383337 0.11 4.04E-03 Itga6 XM_001059465 0.12 0.05 Itpr2 BI274396 0.06 0.03 Jagn1 NM_001044272 -0.04 1.69E-03 Jazf1 ENSRNOT00000039580 0.12 0.03 Jmjd2a ENSRNOT00000027049 -0.2 0.05 Jtb NM_019213 0.05 0.01 Kank3 BP478483 -0.09 0.03 Katna1 NM_001004217 0.07 7.21E-03 Kcna4 NM_012971 0.14 5.34E-03 Kcnb1 NM_013186 0.09 4.57E-03 Kcnb2 NM_054000 0.26 1.96E-03 Kcnc3 NM_053997 0.16 0.02 Kcnj3 NM_031610 0.13 9.30E-03 Kcnj9 g11388871 0.11 5.77E-04 Kcnk1 NM_021688 0.06 0.02 Kcnmb2 NM_176861 -0.2 0.04 Kcnmb4 NM_023960 -0.16 1.80E-03 Page 61 of 288 Diabetes

Kctd2 ENSRNOT00000032608 -0.07 6.77E-03 Kctd6 ENSRNOT00000010303 -0.14 5.32E-06 Ke2 NM_212506 0.04 0.01 Keap1 NM_057152 0.07 4.91E-03 Khdrbs2 NM_133318 -0.11 1.11E-03 Kif1b CK844293 0.06 0.02 Kif20a ENSRNOT00000033784 -0.11 0.01 Kif21a DY472437 -0.12 1.59E-04 Kif3b XM_001061322 0.05 0.01 Kit 703828841J1 -0.18 1.66E-04 Kitl AB105879 -0.27 2.79E-05 Klc2 ENSRNOT00000041238 0.11 3.51E-03 Klf2 NM_001007684 -0.11 2.63E-03 Klf7 g3704598 -0.1 5.65E-03 Klf9 AI113128 -0.04 0.05 Klhdc2 NM_001034133 0.04 2.86E-03 Klhdc3 NM_001012203 0.06 0.03 Klhdc5 XM_001074361 0.14 3.83E-03 Klhl14 ENSRNOT00000020697 0.09 0.03 Klhl18 g4256435 -0.07 0.03 Klhl24 NM_181473 -0.17 3.76E-05 Klrb1a NM_001010964 -0.09 0.05 Kpna4 NM_001014793 0.09 0.04 Kras NM_031515 -0.1 0.03 Kremen1 NM_053649 -0.12 0.01 Krt35 NM_001008820 0.09 3.21E-03 Ktelc1 ENSRNOT00000051428 0.05 2.70E-03 Kti12 NM_001044288 0.04 0.02 Lactb2 NM_001024247 0.08 0.01 Lamc1 ENSRNOT00000003605 0.11 0.02 Large ENSRNOT00000018434 -0.11 3.19E-06 Larp6 ENSRNOT00000017147 0.08 0.04 Lasp1 NM_032613 -0.04 0.04 Lass2 CF110567 -0.23 2.93E-12 Lats2 XM_001063422 -0.09 0.02 Lcmt1 NM_199405 0.05 0.02 Lcn12 ENSRNOT00000020997 -0.05 0.02 Lcn6 NM_001001519 0.06 0.03 Lcp2 NM_130421 -0.07 7.58E-03 Ldhb NM_012595 0.27 1.01E-08 Leng1 ENSRNOT00000017546 0.05 0.02 Leprot g8082072 -0.13 3.00E-03 Leprotl1 NM_001013188 -0.06 0.02 Lgr5 ENSRNOT00000005814 0.09 0.03 Lig1 NM_030855 0.04 0.03 Lima1 ENSRNOT00000026265 -0.07 0.03 Limd2 NM_001025715 -0.32 5.32E-43 Diabetes Page 62 of 288

Lin7a NM_053514 0.11 4.65E-03 Lipa g14924219 0.13 7.93E-03 Llgl2 BC110052 0.07 9.24E-03 Lmo7 NM_001001515 -0.13 0.05 LOC679931 XM_001056792 0.09 5.12E-03 LOC680039 XM_001054238 0.06 0.03 LOC680477 ENSRNOT00000020576 0.07 0.03 LOC681015 ENSRNOT00000056546 0.1 8.41E-05 LOC681086 XM_001060262 0.05 9.48E-04 LOC685203 XM_001062790 -0.14 0.03 LOC685284 ENSRNOT00000013615 0.04 0.04 LOC685385 ENSRNOT00000056523 -0.12 0.02 LOC685398 XM_001079065 -0.04 4.21E-03 LOC685487 ENSRNOT00000013651 -0.05 0.04 LOC686075 ENSRNOT00000039720 0.06 0.04 LOC686117 ENSRNOT00000006151 -0.12 0.01 LOC686143 ENSRNOT00000032698 -0.15 3.62E-03 LOC688558 ENSRNOT00000047859 0.09 5.97E-03 LOC689134 XM_001069684 0.06 0.02 LOC689176 CN540525 -0.21 0.03 LOC689226 CN541495 -0.15 9.71E-04 LOC689296 ENSRNOT00000029411 -0.11 9.52E-04 LOC689572 ENSRNOT00000047630 -0.06 6.59E-03 LOC689574 XM_001068230 0.05 9.28E-04 LOC689593 ENSRNOT00000026467 0.07 0.05 LOC690470 ENSRNOT00000012214 -0.1 1.20E-05 LOC691024 CD372876 -0.1 0.04 LOC691862 XM_001080848 0.13 3.76E-04 Lonrf1 ENSRNOT00000015142 0.08 1.38E-05 Lpcat1 ENSRNOT00000024111 0.08 4.77E-03 Lpl 704209239H1 0.17 1.04E-03 Lppr4 NM_001001508 0.08 1.07E-05 Lrfn2 DQ070869 0.13 0.03 Lrig2 ENSRNOT00000027042 0.05 0.04 Lrit2 ENSRNOT00000038771 0.05 0.05 Lrp11 ENSRNOT00000062020 -0.05 0.02 Lrpap1 ENSRNOT00000012665 0.07 0.05 Lrrc27 CN543288 0.12 0.04 Lrrc28 ENSRNOT00000033858 0.13 1.19E-04 Lrrc40 NM_001034926 0.04 8.23E-03 Lrrc59 NM_001008280 0.09 1.89E-05 Lrrcc1 AF421192 0.1 9.91E-04 Lrrfip1 NM_001014269 -0.22 7.58E-06 Lrrfip2 704319971J1 -0.12 0.01 Lrrn3 NM_030856 0.09 9.37E-03 Lsm1 ENSRNOT00000020721 0.08 5.91E-04 Lsm4 ENSRNOT00000026567 -0.19 1.48E-16 Page 63 of 288 Diabetes

Lsm8 ENSRNOT00000011456 -0.27 1.60E-21 Ltbp2 NM_021586 0.07 0.03 Luc7l2 ENSRNOT00000008557 -0.18 0 Lypd1 NM_001007727 0.08 9.42E-03 Lypla2 NM_031342 0.06 2.37E-05 Lypla3 NM_001004277 0.12 2.13E-03 Lysmd1 NM_001024302 0.08 5.06E-03 Mad2l1bp NM_001009699 0.08 5.69E-03 Mad2l2 NM_001012106 0.07 0.02 Maea NM_001008319 0.05 2.25E-03 Mafg NM_022386 -0.1 0.03 Mafk NM_145673 -0.08 9.55E-03 Map1b XM_001061557 0.03 0.02 Map1lc3b NM_022867 0.06 2.52E-03 Map2k4 702794086T2 0.07 0.03 Map3k2 ENSRNOT00000018975 0.13 9.01E-03 Map3k3 ENSRNOT00000011406 -0.2 3.83E-10 Map3k4 XM_001062918 -0.17 1.61E-10 Map4k2 XM_001071701 0.07 0.04 Map4k3 XM_001055154 0.06 9.58E-03 Mapk1 BM422632 -0.34 0.02 Mapk8 CB782828 -0.11 0.01 Mapkapk2 NM_178102 -0.41 3.77E-14 Mapt NM_017212 -0.18 1.06E-17 Marcksl1 NM_030862 0.05 8.14E-03 Mars2 ENSRNOT00000021140 -0.08 6.53E-03 Mast4 XM_001063274 0.08 3.79E-03 Mat1a NM_012860 0.07 0.02 Matk NM_021859 -0.08 0.05 Max BC099778 0.07 8.04E-06 Mcam AB035506 -0.09 2.29E-04 Mcart1 NM_001024785 -0.09 1.65E-04 Mcfd2 NM_139253 0.06 0.01 Mcm2 XM_001072364 -0.1 3.96E-05 Mcm5 XM_001064207 -0.06 0.04 Mdp1 ENSRNOT00000026914 0.05 1.41E-03 Mea1 NM_001044286 0.05 0.04 Med10 ENSRNOT00000023161 0.04 4.98E-04 Med27 ENSRNOT00000019157 -0.06 8.70E-05 Med28 ENSRNOT00000004912 0.05 0.04 Med4 NM_001024256 0.04 0.05 Med6 ENSRNOT00000009483 0.07 0.01 Melk ENSRNOT00000018650 -0.37 0 Mertk NM_022943 -0.07 9.34E-03 Mesdc2 NM_001008345 -0.05 3.33E-03 Mesp1 ENSRNOT00000020117 0.09 0.01 Metrnl NM_001014104 0.05 0.01 Diabetes Page 64 of 288

Mettl10 ENSRNOT00000023121 0.07 5.26E-03 Mettl6 NM_001007623 0.06 0.02 Mettl8 ENSRNOT00000058526 -0.07 0.05 Mfap3 NM_001007609 0.07 3.02E-04 Mfap3l NM_001012049 0.09 0.01 Mfng NM_199110 0.08 0.04 Mgat2 NM_053604 0.06 0.04 Mgea5 CK226272 -0.11 0.03 Mier1 ENSRNOT00000009438 -0.11 0.01 Mier3 ENSRNOT00000017571 0.08 3.35E-04 Mif4gd NM_001014122 -0.15 9.27E-09 Mknk2 NM_001011985 -0.18 9.79E-04 Mlf1 ENSRNOT00000017143 0.09 1.90E-03 Mll1 BF414399 -0.09 0.01 Mmrn2 XM_001059491 0.06 0.04 Moap1 BI277056 0.08 3.10E-03 Mobkl1b NM_001033891 -0.11 2.83E-05 Morc2a g3638011 0.06 8.35E-03 Mos g11396947 0.12 0.01 Mospd4 ENSRNOT00000004747 0.07 0.03 Mphosph10 CO397835 0.05 0.04 Mphosph9 ENSRNOT00000049985 0.08 8.39E-03 Mras NM_012981 0.11 3.73E-04 Mreg ENSRNOT00000021152 0.15 2.00E-03 Mrpl12 NM_001029900 0.09 5.55E-07 Mrpl13 NM_001006985 0.04 0.01 Mrpl19 NM_001029898 0.04 0.02 Mrpl32 ENSRNOT00000021433 -0.07 0.02 Mrpl35 ENSRNOT00000012021 0.04 0.04 Mrpl47 NM_001037183 0.1 0.03 Mrpl53 ENSRNOT00000011427 0.03 0.03 Mrps11 ENSRNOT00000025008 -0.23 3.67E-31 Mrps17 ENSRNOT00000001229 -0.13 1.32E-05 Mrps2 ENSRNOT00000013548 0.07 9.21E-03 Mrps5 ENSRNOT00000020451 0.03 0.05 Mrto4 ENSRNOT00000024326 0.06 0.02 Msi2 BF388985 -0.15 6.80E-09 Msl2l1 g8500991 -0.08 0.02 Msl31 NM_001014111 -0.11 1.06E-03 Msrb2 NM_001031660 -0.04 6.23E-03 Mtap6 ENSRNOT00000055323 -0.05 0.03 Mtdh NM_133398 -0.12 0.01 Mterfd2 NM_001037209 0.07 0.02 Mthfs NM_001009349 -0.24 1.01E-09 Mtmr7 ENSRNOT00000015625 0.04 0.01 Mto1 XM_217208 -0.15 6.71E-05 Mtus1 NM_178093 -0.07 6.02E-04 Page 65 of 288 Diabetes

Mtx2 NM_001008286 0.07 1.16E-03 Mybl2 ENSRNOT00000010343 0.09 1.80E-03 Mycbp2 ENSRNOT00000014583 -0.17 3.73E-23 Myd88 NM_198130 0.06 0.02 Myeov2 CB313601 0.04 0.05 Myh10 NM_031520 0.03 4.95E-03 Myo6 ENSRNOT00000016428 -0.08 9.10E-03 Myocd NM_182667 -0.1 0.04 Myt1l AW527153 -0.14 5.26E-03 Nab1 NM_022856 0.1 4.62E-03 Nap1l1 703942719J1 -0.43 5.83E-24 Nap1l2 NM_001024789 -0.14 9.15E-06 Nap1l5 NM_001044293 0.13 0.04 Nars BQ204312 0.06 3.02E-03 Nat13 ENSRNOT00000059664 0.06 0.05 Nat5 ENSRNOT00000014046 0.05 0.04 Ncam1 CB791294 0.06 0.02 Ncaph XM_001055639 0.06 1.06E-03 Nck2 ENSRNOT00000023029 0.05 0.02 Ncoa3 BI294907 0.11 2.15E-03 Ncor1 ENSRNOT00000057682 0.08 0.02 Ndfip1 NM_001013059 -0.05 6.43E-03 Ndrg4 NM_031967 -0.15 0.03 Ndst2 ENSRNOT00000035100 0.1 6.99E-03 Ndufa5 NM_012985 0.05 1.41E-04 Ndufb5 ENSRNOT00000016051 -0.1 9.51E-05 Ndufb7 ENSRNOT00000035890 0.03 0.05 Ndufb9 ENSRNOT00000012616 -0.1 5.84E-07 Ndufs4 CK838765 -0.06 6.80E-04 Ndufv2 NM_031064 0.03 9.86E-03 Necap1 NM_001029919 -0.31 2.66E-31 Nefl NM_031783 0.13 0.02 Nefm NM_017029 0.15 8.82E-03 Nek8 ENSRNOT00000017264 -0.11 1.21E-03 Neto2 ENSRNOT00000021739 -0.1 7.58E-03 Nfatc2ip NM_001007692 -0.19 5.03E-05 Nfatc3 ENSRNOT00000025402 0.09 3.28E-03 Nfe2l2 CK471682 0.1 0.04 Nfib NM_031566 -0.12 0.01 Nfyb NM_031553 0.07 5.74E-04 Ngfr NM_012610 -0.06 0.02 Ngly1 NM_001014136 -0.15 2.00E-09 Nhlrc3 ENSRNOT00000014562 -0.15 9.54E-04 Nin ENSRNOT00000052408 -0.08 0.03 NIPBL g11404332 0.06 0.04 Nkiras2 ENSRNOT00000024543 -0.06 0.02 Nkx2-2 ENSRNOT00000017364 0.08 5.72E-03 Diabetes Page 66 of 288

Nle1 ENSRNOT00000011320 -0.08 9.30E-03 Nlrp10 ENSRNOT00000020393 -0.08 0.02 Noc4l NM_001014129 0.06 7.63E-03 Nol4 ENSRNOT00000041125 -0.11 5.89E-04 Nol7 CB556727 0.05 9.64E-03 Nolc1 M94288 0.05 0.02 Notch3 NM_020087 0.05 0.02 Nova1 ENSRNOT00000044527 -0.22 5.26E-08 Npap60 ENSRNOT00000055922 0.05 0.01 Nr2f1 NM_031130 0.1 0.01 Nr2f6 BM986486 0.06 0.04 Nr3c1 Y00489 0.2 0.01 Nras 704354910J1 -0.08 3.84E-04 Nrep NM_178096 -0.21 1.09E-11 Nrg1 AY973241 0.1 0.02 Nsun2 ENSRNOT00000023641 0.05 8.91E-03 Nsun6 ENSRNOT00000025046 0.05 0.02 Nt5c3 ENSRNOT00000007995 0.07 2.74E-03 Nudc NM_017271 0.04 0.01 Nudt19 NM_001004258 0.06 0.01 Nudt4 NM_053598 -0.23 3.43E-10 Nufip1 NM_001007758 0.06 0.03 Nup35 NM_001004229 0.07 4.35E-03 Nup54 NM_017361 -0.09 2.67E-03 Nup62 NM_023098 0.07 2.73E-03 Nup98 ENSRNOT00000027590 -0.05 0.05 Nupl1 ENSRNOT00000017204 -0.09 3.10E-07 Nut ENSRNOT00000006876 0.07 0.02 Nxt2 ENSRNOT00000025912 -0.15 0.04 Odf2 NM_017213 0.07 0.02 Ogfod1 DN934519 0.05 0.02 Ogfr NM_053340 0.08 4.96E-03 Ogfrl1 NM_001025708 0.1 2.69E-05 Ogg1 NM_030870 0.05 0.03 Olfm1 NM_053573 -0.38 3.00E-21 Olr1016 NM_001000070 0.09 0.02 Olr1410 NM_001000784 -0.13 0.03 Olr1607 NM_001000534 0.08 0.02 Olr1718_predicted NM_214460 0.05 6.00E-03 Olr3 NM_001000110 -0.07 5.98E-03 Olr321 NM_001000244 -0.06 0.02 Olr602 NM_001000333 0.06 2.14E-03 Olr782 NM_001000605 0.11 0.02 Opa1 NM_133585 0.04 0.03 Opa3 ENSRNOT00000029552 -0.1 6.99E-05 Oprs1 NM_030996 0.08 1.94E-05 Optc ENSRNOT00000004156 -0.07 8.94E-03 Page 67 of 288 Diabetes

Orc1l NM_177931 0.06 0.05 Orc6l NM_001033690 0.05 9.79E-03 Ormdl2 ENSRNOT00000044292 0.06 5.66E-03 Osbpl5 ENSRNOT00000040748 0.05 9.66E-03 Otub1 ENSRNOT00000028752 -0.04 0.02 Otud7b DV722502 -0.07 0.02 Oxnad1 ENSRNOT00000026751 0.06 6.78E-03 P2ry4 NM_031680 -0.04 0.03 P4ha1 NM_172062 -0.09 0.01 P76 NM_139255 0.04 0.05 Pabpnl1 ENSRNOT00000045052 -0.07 1.73E-03 Pacsin2 NM_130740 -0.1 0.03 Pafah1b1 NM_031763 -0.08 0.02 Paip2 NM_001014148 -0.18 2.15E-08 Pak1 NM_017198 0.08 6.29E-03 Pak2 DY471792 -0.12 4.52E-04 Papd4 NM_001008372 -0.04 7.91E-03 Papd5 ENSRNOT00000033307 -0.12 3.22E-05 Papola BC083612 -0.21 2.07E-14 Paqr3 NM_001012033 -0.29 1.01E-08 Paqr4 NM_001017377 0.05 5.51E-04 Pard3 NM_031235 -0.13 0.02 Parp1 NM_013063 0.05 0.02 Parp12 ENSRNOT00000011481 0.08 0.03 Parp6 BQ780586 -0.12 2.28E-07 Parvb ENSRNOT00000015665 0.08 0.01 Pawr NM_033485 0.12 1.19E-06 Pax6 ENSRNOT00000005882 -0.14 1.34E-04 Pcbp3 NM_001011945 0.09 9.79E-03 Pcdh9 g8512340 0.09 6.99E-03 Pcdhb21 ENSRNOT00000040016 0.08 0.03 Pcdhb4 ENSRNOT00000027210 0.05 0.01 Pcdhb9 ENSRNOT00000050503 0.08 6.63E-03 Pcgf3 CA506321 -0.14 0.02 Pcgf6 NM_001013154 -0.19 8.61E-15 Pcnp XM_001057978 -0.05 5.80E-03 Pctp NM_017225 0.14 2.08E-10 Pdcd2 M80601 0.07 5.22E-04 Pdcd4 NM_022265 -0.07 0.01 Pdcd5 ENSRNOT00000017708 0.03 0.02 Pdcl3 BI289420 -0.11 3.09E-04 Pde1c NM_031078 0.13 2.12E-03 Pde3b 703206608J1 -0.26 4.01E-29 Pde4b M25350 0.14 0.02 Pde7a ENSRNOT00000043859 -0.18 5.30E-10 Pdia4 NM_053849 -0.15 3.00E-03 Pdik1l DV727600 -0.09 0.03 Diabetes Page 68 of 288

Pdlim1 NM_017365 0.07 4.67E-05 Pdlim5 NM_053326 0.08 0.02 Pdrg1 NM_001014762 0.1 1.90E-03 Pds5b ENSRNOT00000001464 0.06 8.50E-04 Pdzd8 ENSRNOT00000012549 0.08 0.03 Pex1 BI296060 -0.05 6.99E-03 Pex3 BC062046 0.05 3.99E-03 Pex5 BC111709 -0.13 0.01 Pex7 NM_001034147 -0.06 8.78E-03 Pfas ENSRNOT00000007087 -0.06 2.56E-03 Pfkfb2 NM_001033965 -0.11 1.23E-05 Pfn2 NM_030873 -0.12 4.79E-10 Pftk1 ENSRNOT00000009417 0.1 0.02 Pgcp AW534444 -0.06 0.03 Pgk2 NM_001012130 0.06 0.05 Pgm2l1 ENSRNOT00000022963 -0.12 4.38E-04 Phb NM_031851 0.08 1.04E-03 Phb2 NM_001013035 0.03 4.06E-03 Phc1 ENSRNOT00000020529 -0.09 0.02 Phf10 NM_001024747 -0.07 8.32E-03 Phf19 BQ196118 0.12 0.01 Phf20l1 ENSRNOT00000007564 -0.21 5.40E-07 Phf5a NM_138888 0.04 0.02 Phlda2 ENSRNOT00000027972 0.1 5.02E-04 Phospho2 NM_001007642 0.07 0.05 Phyhipl NM_001012076 -0.07 0.02 Pi4k2b NM_001005883 -0.21 2.37E-04 Pigm NM_024144 0.11 0.04 Pigo ENSRNOT00000013213 0.04 9.08E-03 Pigq NM_001007607 -0.09 2.71E-06 Pigs NM_001006602 0.07 6.96E-04 Pigw NM_194461 0.07 0.02 Pim1 NM_017034 -0.13 0.02 Pitpna NM_017231 0.05 1.50E-03 Pja2 NM_138896 -0.09 2.51E-05 Pkn2 ENSRNOT00000015458 -0.05 0.04 Pla2g4c ENSRNOT00000033633 0.07 0.04 Pla2g6 NM_001005560 -0.23 1.01E-08 Plaa NM_053866 -0.06 0.05 Plagl1 NM_012760 -0.14 2.06E-03 Plagl2 XM_001061140 0.13 0.03 Plcb1 L14323 -0.14 4.77E-04 Plcl1 AI072447 -0.1 8.41E-03 Plek2 ENSRNOT00000014125 0.06 2.08E-03 Plekha3 NM_001013077 -0.13 0.04 Plekhf2 AI171635 0.12 0.03 Plekhm1l ENSRNOT00000032782 -0.1 0.02 Page 69 of 288 Diabetes

Pnpla2 ENSRNOT00000025319 0.07 3.05E-03 Pnpla8 704297787J1 -0.09 0.01 Pnpo NM_022601 -0.14 1.37E-04 Pnpt1 BC092603 0.03 0.03 Pnrc1 NM_173322 -0.18 7.01E-05 Polb NM_017141 0.09 2.08E-04 Pold2 NM_001013050 0.04 0.03 Pole3 BC081988 -0.21 2.44E-08 Polr1e ENSRNOT00000029704 0.08 9.33E-04 Polr2g NM_053948 -0.04 0.02 Polr2j ENSRNOT00000001941 -0.16 8.83E-05 Polr3b XM_343188 -0.06 0.04 Polr3d NM_001031653 0.08 2.32E-05 Polr3h ENSRNOT00000005943 0.07 6.34E-03 Pols ENSRNOT00000023712 -0.08 0.02 Pom121 NM_053622 -0.2 4.19E-05 Pomgnt1 NM_001007747 0.05 0.03 Pomt2 NM_001037097 0.05 0.03 Pop4 NM_001009642 0.06 2.44E-03 Pou2af1 ENSRNOT00000015972 0.07 4.05E-03 Pp3111 NM_172018 0.06 2.85E-04 Ppargc1b NM_176075 0.12 6.72E-03 Ppfibp1 ENSRNOT00000044147 -0.1 3.71E-03 Pphln1 AY724510 0.09 0.03 Ppif NM_172243 0.11 2.52E-06 Ppig NM_031793 -0.17 3.73E-05 Ppm1d 704156493J1 0.05 0.03 Ppm1f NM_175755 0.08 9.36E-04 Ppp1cb NM_013065 -0.08 1.60E-03 Ppp1r11 NM_212542 0.06 4.17E-03 Ppp1r14b NM_172045 -0.34 3.79E-26 Ppp1r3b NM_138912 -0.11 0.04 Ppp1r3d 700371222F6 -0.13 5.16E-05 Ppp1r9b NM_053474 0.08 0.02 Ppp2cb NM_017040 0.05 3.84E-03 Ppp2r1a NM_057140 -0.17 8.76E-08 Ppp2r1b NM_001025418 0.07 6.25E-03 Ppp2r2b D14421 0.12 4.49E-03 Ppp2r2d NM_144746 0.06 4.17E-05 Ppp2r5c XM_001077680 -0.11 2.99E-05 Ppp2r5d ENSRNOT00000022862 0.06 0.04 Ppp3r1 NM_017309 0.07 5.81E-03 Ppp4c NM_134359 -0.09 2.26E-07 Ppp6c NM_133589 0.05 0.02 Ppt1 ENSRNOT00000017998 -0.1 2.98E-03 Pptc7 g8500113 0.07 0.03 Pqlc1 NM_001013189 0.12 1.06E-03 Diabetes Page 70 of 288

Pqlc2 ENSRNOT00000023896 0.07 7.40E-03 Pqlc3 NM_001034952 0.06 4.52E-03 Praf2 XM_001058767 0.07 0.04 Prelid1 NM_001009636 -0.07 3.22E-03 Prkaa1 BM392332 -0.11 2.22E-03 Prkaa2 NM_023991 -0.18 0.03 Prkag1 NM_013010 -0.03 0.02 Prkar1a CF110967 -0.16 4.60E-08 Prkar2a g18186932 0.12 5.02E-06 Prkcd NM_133307 0.06 0.03 Prkce CR457587 -0.15 5.38E-03 Prkd3 ENSRNOT00000007492 -0.3 1.76E-06 Prkrir AI137858 0.09 0.02 Prmt2 NM_001025144 -0.04 4.29E-03 Prmt3 NM_053557 -0.06 0.03 Prmt5 XM_001054376 0.06 6.07E-03 Prosc ENSRNOT00000018369 0.08 1.22E-04 Prpf31 ENSRNOT00000018683 0.08 0.02 Prpf38a ENSRNOT00000012635 0.06 0.02 Prps1 M17258 -0.14 0.02 Prr5 NM_001012121 0.11 0.02 Prss22 ENSRNOT00000060888 -0.07 0.02 Prune NM_001007697 -0.14 8.69E-05 Psat1 NM_198738 -0.06 0.05 Psd4 ENSRNOT00000008161 0.08 0.02 Psip1 BC093606 -0.12 8.52E-04 Pskh1 ENSRNOT00000026163 -0.09 5.65E-03 Psma7 NM_001008217 0.03 0.03 Psmd10 NM_053925 0.07 3.24E-03 Psmd12 NM_001005875 -0.09 1.45E-04 Psmd2 NM_001031639 -0.04 5.30E-03 Psme3 NM_001011894 0.08 8.37E-04 Psx1 XM_231064 0.07 0.04 Ptbp2 NM_001005555 -0.08 2.06E-03 Ptch1 NM_053566 0.04 0.05 Ptdss2 ENSRNOT00000021925 0.06 0.01 Ptgds2 NM_031644 -0.06 0.04 Ptma NM_021740 0.06 0.04 Ptp4a1 ENSRNOT00000016237 0.05 4.25E-03 Ptpmt1 ENSRNOT00000013584 0.08 9.18E-07 Ptpn11 AW435132 0.31 6.31E-05 Ptpn13 ENSRNOT00000061162 0.07 0.03 Ptpn2 NM_053990 0.04 0.03 Ptpn9 NM_001013040 -0.09 1.13E-03 Purb NM_001017503 -0.14 3.57E-04 PVR NM_017076 0.18 4.66E-08 Pvrl1 703899705J1 0.09 0.05 Page 71 of 288 Diabetes

Pwp1 ENSRNOT00000007549 -0.14 5.60E-05 Pxmp4 NM_172223 0.09 0.02 Pycr2 NM_001012208 0.09 2.79E-04 Pycrl NM_001011993 0.04 0.02 Pygo2 ENSRNOT00000028052 -0.11 3.19E-03 Pzp NM_145779 -0.07 0.05 Qpctl ENSRNOT00000021200 0.07 0.03 R3hcc1_predicted ENSRNOT00000022706 0.06 0.02 R3hdm1 ENSRNOT00000005372 0.05 7.82E-04 Rab10 NM_017359 -0.1 1.13E-04 Rab11a NM_031152 -0.11 3.00E-04 Rab15 NM_198749 -0.13 0.02 Rab18 NM_001012468 -0.08 0.01 Rab19 NM_001024326 0.05 0.02 Rab27a 703964422J1 -0.12 4.21E-03 Rab28 NM_053978 0.05 4.01E-03 Rab31 NM_145094 0.06 0.05 Rab33b DV725908 -0.21 2.04E-06 Rab36 ENSRNOT00000001772 -0.09 4.97E-07 Rab40c NM_182675 -0.22 3.88E-04 Rabl2a NM_001013221 -0.13 6.00E-03 Rad23b NM_001025275 0.03 0.04 Ralb NM_053821 0.09 1.25E-05 Ramp3 NM_020100 0.06 0.04 Rap1b BC081731 -0.2 1.03E-04 Rap2a BQ208481 0.11 9.44E-04 Rapgef4 ENSRNOT00000048797 -0.05 0.02 Rars XM_213276 0.03 0.03 Rasa1 CF249348 -0.16 9.20E-09 Rassf3 AA893698 -0.11 1.01E-03 Raver2 XM_001061591 0.12 4.39E-04 Rb1cc1 ENSRNOT00000010014 -0.07 0.02 Rbbp6 CA508745 0.05 5.34E-04 Rbl1 ENSRNOT00000009528 -0.11 3.39E-04 Rbm18 XM_001080367 -0.06 7.34E-04 Rbm34 BI288659 0.07 0.03 Rbm45 NM_153306 -0.05 0.02 Rbm5 BC089976 -0.06 0.04 Rc3h2 ENSRNOT00000012354 -0.16 3.59E-04 Rcbtb1 ENSRNOT00000037800 0.06 0.04 Rcc2 ENSRNOT00000008940 -0.14 1.15E-06 rCG_22919 ENSRNOT00000020889 -0.2 1.21E-07 rCG_33565 g3814135 0.04 4.71E-03 Rchy1 NM_001007618 -0.04 5.25E-03 Rcn2 NM_017132 0.07 1.81E-04 Rdx BF557204 -0.09 0.02 Reck ENSRNOT00000020755 0.06 0.04 Diabetes Page 72 of 288

Reg1 NM_012641 -0.08 0.04 Rell1 ENSRNOT00000002984 -0.18 1.02E-06 Rfc2 NM_053786 0.05 9.04E-03 Rfx5 BC089912 -0.12 2.28E-03 Rg9mtd3 NM_001013090 0.03 0.05 RGD1303003 NM_001004225 0.04 0.04 RGD1304607 ENSRNOT00000028079 0.06 0.01 RGD1304719 NM_001037769 -0.04 5.13E-03 RGD1304773 NM_001025126 0.07 1.59E-03 RGD1304840 ENSRNOT00000037211 -0.1 9.98E-03 RGD1304924 ENSRNOT00000030458 0.09 0.02 RGD1304963 g13298705 0.12 0.03 RGD1305014 NM_001014025 0.07 0.01 RGD1305045 ENSRNOT00000008364 0.03 0.02 RGD1305138 XM_235689 0.08 0.03 RGD1305222 ENSRNOT00000019363 0.05 0.03 RGD1305235 BQ193237 -0.2 9.76E-05 RGD1305347 ENSRNOT00000027432 0.11 0.01 RGD1305592 NM_001013901 -0.13 1.24E-14 RGD1305793 XM_001067855 0.13 4.14E-04 RGD1306437 NM_001009635 0.03 0.03 RGD1306502 DV722552 -0.05 4.42E-05 RGD1306583 NM_001013908 0.04 0.03 RGD1306595 NM_001025626 -0.06 0.01 RGD1306703 ENSRNOT00000021756 -0.09 6.32E-03 RGD1306730 NM_001039608 0.05 2.70E-04 RGD1306772 NM_001044226 -0.03 0.03 RGD1306783 NM_001025668 0.07 5.33E-03 RGD1306820 ENSRNOT00000023827 -0.07 0.04 RGD1306924 ENSRNOT00000018460 0.06 0.02 RGD1306936 ENSRNOT00000011970 0.04 0.02 RGD1306962 ENSRNOT00000021944 0.08 0.05 RGD1307067 ENSRNOT00000015869 0.08 0.01 RGD1307119 NM_001013975 0.06 0.02 RGD1307234 XM_001056555 -0.1 1.27E-03 RGD1307254 NM_001024875 0.07 3.50E-03 RGD1307288 ENSRNOT00000055118 0.06 0.04 RGD1307325 NM_001014001 -0.35 4.23E-12 RGD1307443 ENSRNOT00000024536 0.09 0.04 RGD1307465 NM_001009655 -0.07 0.05 RGD1307526 ENSRNOT00000019984 -0.17 3.49E-03 RGD1307537 BF408798 -0.06 0.03 RGD1307554 CO404930 -0.09 1.51E-03 RGD1307696 DW395452 -0.13 6.96E-03 RGD1307752 NM_001013922 0.04 0.02 RGD1307773 BQ210499 0.07 3.99E-03 RGD1307830 XM_222746 -0.19 9.53E-05 Page 73 of 288 Diabetes

RGD1307882 BE104233 0.09 0.03 RGD1308048 BE099049 -0.12 6.74E-03 RGD1308134 ENSRNOT00000025491 -0.04 0.01 RGD1308143 BC083847 -0.16 8.34E-04 RGD1308179 ENSRNOT00000005504 0.17 0.03 RGD1308221 XM_001073298 -0.13 0.02 RGD1308297 BC082039 -0.06 0.03 RGD1308432 CA509333 0.07 0.02 RGD1308470 NM_001014198 0.08 5.59E-03 RGD1308600 NM_001014178 0.1 3.75E-04 RGD1308635 ENSRNOT00000025386 0.06 2.89E-04 RGD1308706 ENSRNOT00000023169 -0.16 3.00E-06 RGD1308782 NM_001025677 0.11 5.40E-03 RGD1308847 NM_001100945 0.11 3.47E-03 RGD1308915 DY470960 0.13 4.22E-03 RGD1309104 BE111666 -0.15 3.62E-06 RGD1309216 NM_001008371 0.07 2.26E-03 RGD1309228 g14949127 0.07 5.07E-03 RGD1309360 ENSRNOT00000018058 -0.1 0.02 RGD1309459 ENSRNOT00000004159 0.05 0.01 RGD1309594 NM_001008351 0.04 0.02 RGD1309676 NM_001014140 -0.07 0.02 RGD1309759 ENSRNOT00000020810 0.08 0.02 RGD1309779 ENSRNOT00000011017 -0.16 2.75E-17 RGD1309784 NM_001014212 -0.18 2.22E-07 RGD1309871 XM_001076952 -0.23 1.55E-19 RGD1309995 BC091295 -0.18 1.18E-05 RGD1310185 ENSRNOT00000032301 -0.08 0.02 RGD1310260 ENSRNOT00000010832 -0.06 0.05 RGD1310351 XM_216499 0.09 3.93E-03 RGD1310352 ENSRNOT00000008119 -0.21 1.65E-15 RGD1310358 CO402386 -0.14 9.91E-03 RGD1310427 ENSRNOT00000024450 -0.27 3.66E-19 RGD1310553 NM_001008517 -0.12 5.71E-03 RGD1310571 AI599496 0.07 3.19E-03 RGD1310606 NM_001024984 0.07 1.58E-03 RGD1310660 NM_001009316 0.08 1.66E-06 RGD1310686 703920155J1 0.07 0.01 RGD1310784 ENSRNOT00000020637 0.09 1.51E-08 RGD1310794 NM_001024246 -0.13 2.33E-04 RGD1310975 ENSRNOT00000017800 0.07 3.45E-03 RGD1311077 ENSRNOT00000010768 -0.06 0.03 RGD1311122 NM_001037792 -0.08 5.33E-03 RGD1311142 XM_001077811 -0.1 0.02 RGD1311257 CK841027 0.07 0.02 RGD1311260 NM_001013967 0.09 1.15E-04 RGD1311435 ENSRNOT00000055607 -0.09 7.77E-03 Diabetes Page 74 of 288

RGD1311634 ENSRNOT00000055252 0.06 0.01 RGD1311784 ENSRNOT00000005337 0.06 0.04 RGD1311815 NM_001034149 0.12 4.05E-05 RGD1311863 NM_001024974 0.08 0.05 RGD1311899 NM_001009630 0.05 7.52E-03 RGD1311925 BC098826 -0.1 1.57E-08 RGD1311946 NM_001025683 0.15 2.95E-03 RGD1359108 NM_001007702 -0.07 1.86E-03 RGD1359127 NM_001007657 0.09 4.65E-05 RGD1359156 NM_001005531 0.11 0.01 RGD1359158 NM_001007737 -0.4 1.88E-16 RGD1359191 NM_001007706 0.06 0.02 RGD1359713 NM_001005882 0.12 1.47E-05 RGD1559610 ENSRNOT00000009882 0.05 5.50E-05 RGD1559690 ENSRNOT00000031974 -0.19 8.23E-06 RGD1559904 CK839407 0.06 0.02 RGD1559923 ENSRNOT00000020074 -0.3 1.26E-19 RGD1559982 XM_219714 0.08 0.03 RGD1560010 ENSRNOT00000013356 -0.33 2.80E-10 RGD1560065 ENSRNOT00000019964 0.1 2.48E-09 RGD1560258 ENSRNOT00000001218 0.06 8.90E-03 RGD1560277 XM_001066043 0.09 1.97E-03 RGD1560286 ENSRNOT00000045226 0.07 2.25E-03 RGD1560513 XM_001077597 0.05 0.02 RGD1560612 703706635J1 -0.09 0.05 RGD1560812 XM_576015 -0.14 0.03 RGD1560818 704237816J1 0.1 0.04 RGD1560888 XM_001061556 0.06 0.02 RGD1560909 ENSRNOT00000031352 0.04 6.74E-03 RGD1560943 ENSRNOT00000046589 0.06 0.02 RGD1561057 XM_578135 -0.04 0.03 RGD1561067 XM_573923 -0.24 2.95E-08 RGD1561069 NM_001044259 0.08 6.19E-03 RGD1561141 XM_230015 -0.25 3.04E-27 RGD1561205 ENSRNOT00000056229 0.06 0.03 RGD1561237 ENSRNOT00000000010 0.09 0.01 RGD1561302 CK597015 -0.09 0.01 RGD1561412 XM_573750 -0.06 0.04 RGD1561539 ENSRNOT00000014468 -0.1 0.03 RGD1561605 BP465710 -0.17 0.01 RGD1561654 XM_001079552 -0.08 0.01 RGD1562012 ENSRNOT00000056192 -0.06 0.04 RGD1562136 ENSRNOT00000045749 0.07 0.04 RGD1562218 NM_001034919 -0.17 1.34E-05 RGD1562351 XM_001062525 0.06 6.87E-03 RGD1562492 ENSRNOT00000051280 -0.12 1.39E-03 RGD1562502 ENSRNOT00000003667 -0.21 7.39E-12 Page 75 of 288 Diabetes

RGD1562529 AA946404 -0.13 1.48E-07 RGD1562809 ENSRNOT00000044828 0.05 0.03 RGD1562899 ENSRNOT00000002518 -0.07 0.03 RGD1562952 CO384193 -0.07 0.04 RGD1562965 AA851969 -0.18 9.39E-03 RGD1562997 XM_001073245 -0.15 5.93E-03 RGD1563170 ENSRNOT00000058701 0.08 0.02 RGD1563216 XM_576075 0.07 5.53E-05 RGD1563226 ENSRNOT00000035153 0.08 8.47E-03 RGD1563325 ENSRNOT00000009154 0.05 0.03 RGD1563331 ENSRNOT00000004191 -0.12 0.02 RGD1563451 XM_227350 -0.11 0.03 RGD1563532 ENSRNOT00000014135 0.08 0.02 RGD1563612 ENSRNOT00000011395 -0.39 3.35E-15 RGD1563634 NM_001081447 0.07 2.79E-03 RGD1563666 ENSRNOT00000057378 0.11 0.05 RGD1563669 DY316927 -0.07 0.03 RGD1563853 ENSRNOT00000026653 -0.1 9.75E-04 RGD1563952 XM_001071071 0.14 8.70E-13 RGD1564209 XM_001053896 -0.16 2.61E-04 RGD1564304_predicted ENSRNOT00000045312 0.07 0.04 RGD1564454 XM_575014 -0.13 1.80E-07 RGD1564456 ENSRNOT00000048933 -0.11 1.30E-04 RGD1564515 ENSRNOT00000056894 -0.1 0.05 RGD1564560 BF289687 0.12 0.02 RGD1564778 ENSRNOT00000055330 -0.06 5.86E-03 RGD1564799 DY471778 -0.18 1.40E-04 RGD1564811 ENSRNOT00000006325 -0.11 4.18E-03 RGD1564887 703124629T1 -0.07 0.02 RGD1564937 ENSRNOT00000050399 -0.08 0.02 RGD1565002 ENSRNOT00000007645 0.05 1.41E-03 RGD1565030 XM_001064873 0.05 0.02 RGD1565052 NM_001044696 0.19 0.01 RGD1565247 ENSRNOT00000023642 -0.09 3.15E-05 RGD1565306 XM_001077524 0.06 2.81E-03 RGD1565310 ENSRNOT00000061677 -0.14 1.03E-06 RGD1565561 ENSRNOT00000059774 0.09 2.09E-03 RGD1565760 ENSRNOT00000036392 -0.08 6.25E-03 RGD1566102 BQ201181 -0.12 0.02 RGD1566149 XM_573150 0.07 0.02 RGD1566319 XM_578496 -0.09 6.14E-03 RGD1566320 ENSRNOT00000055588 0.09 4.18E-03 RGD1566326 ENSRNOT00000051901 0.08 0.04 RGD1566396 ENSRNOT00000010672 0.05 5.59E-03 RGD1566403 ENSRNOT00000024476 -0.06 0.03 RGD735065 NM_199379 -0.1 3.67E-10 RGD735112 BI288756 0.07 0.01 Diabetes Page 76 of 288

RGD735140 NM_198779 -0.1 0.02 Rgs17 ENSRNOT00000025355 0.09 9.26E-04 Rgs9bp ENSRNOT00000017172 0.06 0.04 Rhbdl2 XM_001055537 -0.08 5.11E-03 Rhobtb2 NM_001013133 0.07 0.02 Rhoq NM_053522 -0.08 1.77E-04 Rif1 g11634864 0.27 0.02 Rimbp3 ENSRNOT00000051991 0.08 0.01 Rims2 NM_053945 -0.08 2.65E-03 Rin2 ENSRNOT00000013957 -0.1 0.02 Rin3 ENSRNOT00000009266 0.05 0.03 Riok2 NM_001009687 0.04 0.01 Riok3 ENSRNOT00000039377 0.05 2.44E-04 Ripk5 NM_199463 -0.16 1.30E-06 Rkhd2 XM_001062342 -0.18 9.67E-22 Rmi1 ENSRNOT00000025812 -0.07 1.25E-03 Rnaseh2b NM_001007007 0.07 0.05 AI598323 0.08 0.02 Rnf11l ENSRNOT00000021681 0.05 2.72E-04 Rnf125 ENSRNOT00000021136 -0.08 4.56E-04 Rnf135 NM_001012010 -0.13 4.03E-07 Rnf138 NM_053588 -0.06 9.84E-03 rnf141 NM_001001800 -0.16 5.52E-04 Rnf144b ENSRNOT00000036876 -0.09 2.79E-03 Rnf167 NM_001008361 0.08 0.02 Rnf181 NM_001007647 0.06 0.02 Rnf185 NM_001024271 0.06 0.02 Rnf19a CB545346 -0.09 1.21E-03 Rnf215 XM_001065855 0.06 0.03 Rnf217 XM_001057827 0.09 1.36E-03 Rnf8 NM_001025727 -0.08 0.03 Rnft1 ENSRNOT00000005064 0.09 0.02 Rnmt NM_001008299 -0.2 2.43E-30 Rnps1 NM_001011890 -0.07 3.52E-04 Rnuxa NM_173133 -0.06 7.82E-03 Rock2 703954794J1 -0.18 1.33E-03 Rpap2 NM_001013987 0.04 0.02 Rpap3 CK845469 0.13 0.02 Rpe NM_001033903 0.09 1.51E-03 Rpl18 NM_031102 -0.08 1.48E-03 Rpl28 NM_022697 0.06 6.85E-03 Rpl7l1 ENSRNOT00000021803 0.06 5.92E-03 Rpo1-1 NM_001008330 0.09 9.67E-05 Rpo1-2 NM_031773 0.07 1.74E-03 Rps19bp1 ENSRNOT00000024085 0.05 0.01 Rraga NM_053973 0.03 0.05 RragB 702955022H1 -0.18 0.01 Page 77 of 288 Diabetes

Rragc NM_001048184 -0.11 1.08E-06 Rras2 CO384798 -0.09 1.83E-03 Rrn3 BC086552 -0.06 0.03 Rtel1 ENSRNOT00000055030 -0.17 8.34E-04 Rtn3 ENSRNOT00000028785 -0.06 0.02 Rtp1 ENSRNOT00000032383 -0.07 0.04 Rwdd1 NM_147146 0.06 0.01 Ryr1 AW530219 0.07 0.04 Sacm1l NM_053798 0.05 0.04 Safb BE108057 0.11 0.05 Samd10 BC099100 0.09 2.26E-04 Samd12 ENSRNOT00000031679 -0.2 3.87E-04 Samd4b BC090319 0.06 0.03 Sap130 ENSRNOT00000022761 0.08 0.02 Sap30l ENSRNOT00000003473 -0.1 0.02 Saps3 XM_001067905 0.06 9.09E-03 Sar1b NM_001009622 0.03 0.04 Sars2 ENSRNOT00000027166 -0.03 0.04 Sart3 ENSRNOT00000000891 -0.1 5.87E-11 Sc5d AB052846 0.05 0.04 Schip1 ENSRNOT00000057473 0.04 0.03 Scmh1 BC131847 0.09 0.01 Scn3b NM_139097 -0.07 5.43E-03 Sco1 ENSRNOT00000044116 0.08 0.02 Scoc NM_001013235 0.05 1.52E-04 Scrib ENSRNOT00000045280 -0.15 6.83E-03 Sdc1 M81785 0.04 0.05 Sdc4 NM_012649 -0.08 0.04 Sdccag10 NM_001013199 0.05 0.02 Sdf2 ENSRNOT00000016297 0.05 8.62E-03 Sdha NM_130428 0.05 4.58E-03 Sec14l1 AI549261 0.07 0.01 Sema4a NM_001012078 -0.12 1.44E-05 Sema4b ENSRNOT00000030914 -0.09 0.02 Sema4c ENSRNOT00000021956 0.08 0.04 Sema4f NM_019272 0.06 3.72E-03 Sema4g ENSRNOT00000019956 -0.1 0.02 Senp7 ENSRNOT00000044177 -0.19 1.99E-08 Sephs1 BG668465 -0.29 0 Serf2 NM_001098782 0.17 1.42E-11 Serinc1 NM_182951 -0.05 0.05 Setd6 ENSRNOT00000016626 0.06 0.04 Sfpq 704240832J1 -0.23 2.30E-07 Sfrs1 DV721035 -0.16 5.99E-08 Sfrs11 NM_001035255 -0.1 5.35E-03 Sfrs12ip1 NM_001008373 0.1 4.73E-07 Sfrs3 NM_001047907 -0.07 7.29E-03 Diabetes Page 78 of 288

Sfrs7 NM_001039035 -0.08 0.02 Sfrs9 NM_001009255 0.05 3.77E-04 Sft2d1 NM_001008302 0.06 1.98E-03 Sft2d2 NM_001034011 -0.16 8.53E-08 Sft2d3 XM_001059433 0.11 2.49E-06 Sfxn2 CK226786 0.05 7.45E-03 Sgk3 XM_001060531 -0.17 8.64E-06 Sgpp2 ENSRNOT00000018882 0.06 0.03 Sh2b3 NM_031621 0.11 1.16E-03 Sh3gl2 ENSRNOT00000008999 0.1 4.40E-06 Sh3glb1 NM_001011929 0.03 0.01 Shank2 NM_133441 -0.07 0.01 Sharpin BI296220 -0.06 7.05E-03 Shbg NM_012650 -0.04 0.03 Shoc2 NM_001013155 -0.13 3.14E-03 Shox2 ENSRNOT00000046307 -0.12 5.46E-03 Shpk NM_001033682 -0.13 6.79E-03 Siae DY315267 -0.12 1.09E-07 Siah2 NM_134457 0.08 7.07E-03 Sidt2 ENSRNOT00000024240 0.05 0.01 Sipa1l3 AI136685 -0.05 0.03 Sirt5 NM_001004256 0.05 9.21E-03 Sirt7 ENSRNOT00000054951 0.09 4.31E-03 Skp2 ENSRNOT00000023099 0.15 0.04 Slain2 XM_001076917 -0.21 1.59E-07 Slc12a3 NM_019345 -0.08 0.03 Slc16a1 NM_012716 0.18 5.76E-04 Slc16a6 NM_198760 -0.11 0.03 Slc19a2 NM_001030024 -0.08 0.04 Slc24a5 ENSRNOT00000043611 0.1 0.03 Slc24a6 NM_001017488 -0.08 0.05 Slc25a12 XM_342445 -0.18 0.05 Slc25a14 NM_053501 0.05 8.06E-04 Slc25a16 ENSRNOT00000029576 0.1 3.00E-03 Slc25a20 X97831 -0.69 9.78E-31 Slc25a37 NM_001013996 0.09 0.04 Slc26a4 NM_019214 -0.06 0.05 Slc29a3 NM_181639 0.09 0.03 Slc2a6 ENSRNOT00000008034 -0.15 1.83E-05 Slc30a4 NM_172066 0.07 1.88E-03 Slc31a2 NM_001033693 -0.1 3.46E-03 Slc35a3 NM_001012082 0.09 7.85E-03 Slc35c1 ENSRNOT00000010278 0.13 2.07E-06 Slc35e1 703865440J1 0.07 0.03 Slc35f2 ENSRNOT00000011966 0.06 0.03 Slc35f5 ENSRNOT00000004581 0.07 4.66E-04 Slc38a1 NM_138832 0.05 0.04 Page 79 of 288 Diabetes

Slc38a9 NM_001035251 0.08 7.18E-04 Slc39a14 BM388554 -0.06 0.05 Slc4a1ap ENSRNOT00000061108 0.08 0.05 Slc4a4 NM_053424 0.12 0.03 Slc5a3 NM_053715 -0.2 1.86E-06 Slc6a20 703956716J1 -0.16 2.98E-04 Slc7a1 CV105154 0.09 0.01 Slc7a5 NM_017353 -0.16 0.02 Slc7a6 ENSRNOT00000027117 0.1 4.19E-10 Slc7a7 NM_031341 0.11 0.02 Slc8a1 AY245281 -0.13 8.14E-03 Slco5a1 ENSRNOT00000011940 -0.07 0.04 Slfn8 NM_001013970 0.09 5.98E-03 Slit2 ENSRNOT00000005477 -0.16 0.02 Slitrk5 ENSRNOT00000057692 0.11 4.00E-03 Slitrk6 ENSRNOT00000038433 -0.14 0.03 Slk CK228000 -0.12 4.64E-05 Smad4 AF056002 -0.11 2.53E-03 Smarca5 ENSRNOT00000024568 -0.07 0.02 Smarcad1 ENSRNOT00000008585 0.11 0.03 Smarcc1 CA505347 0.08 0.01 Smarce1 NM_001024993 0.06 0.02 Smn1 NM_022509 0.08 1.31E-04 Smpd1 NM_001006997 -0.13 1.21E-05 Smpd3 CR465209 -0.07 1.86E-04 Smurf2 AI070734 0.12 0.02 Snapc5 AA892538 0.06 0.05 Snca NM_019169 0.09 1.19E-04 Snf1lk ENSRNOT00000001579 0.22 2.64E-04 Snupn NM_001004270 -0.18 1.33E-06 Snx13 XM_343053 0.08 0.01 Snx16 NM_022289 0.15 1.56E-06 Snx27 NM_152847 -0.22 1.20E-09 Snx7 NM_001012083 0.07 0.02 Soat1 704244751J1 0.09 4.25E-03 Socs2 NM_058208 -0.17 0.02 Socs6 XM_001063512 0.07 2.77E-05 Sod2 BQ782213 -0.26 0.03 Sos1 ENSRNOT00000009359 -0.14 6.61E-06 Sox7 ENSRNOT00000016503 0.09 7.02E-04 Spag9 XM_340879 -0.03 0.04 Spast ENSRNOT00000039375 0.05 0.05 Spata2 NM_053675 0.07 0.05 Spc24 ENSRNOT00000045384 0.04 5.75E-03 Spen ENSRNOT00000047339 0.09 0.04 Spg20 XM_215564 -0.25 1.27E-18 Spint1 NM_001004265 0.07 0.02 Diabetes Page 80 of 288

Spop CB328208 -0.07 0.01 Sppl3 BQ781686 -0.05 9.59E-03 Spred1 ENSRNOT00000007028 -0.2 2.10E-03 Spry4 AW914942 0.07 0.03 Spryd3 ENSRNOT00000055320 -0.09 0.02 Spryd4 NM_001037765 -0.07 7.68E-03 Spsb4 ENSRNOT00000017363 0.1 0.02 Sptlc1 ENSRNOT00000014546 0.04 0.04 Src AA956919 -0.05 0.03 Srcrb4d ENSRNOT00000001953 -0.12 3.59E-05 Srd5a3 NM_001013990 0.06 3.74E-04 Srf ENSRNOT00000061430 0.08 0.04 Srgap3 ENSRNOT00000009066 0.11 0.03 Srpk1 BC090554 -0.11 4.84E-04 Srrm2 CA509585 0.08 0.01 Ssh2 ENSRNOT00000019410 -0.06 0.04 Ssr3 AY724496 -0.09 6.04E-04 Sstr2 NM_019348 0.1 0.03 Ssu72 CK842219 -0.07 0.05 Ssx2ip NM_175597 -0.44 0 St3gal5 CK473297 0.07 0.04 St5 XM_219273 -0.08 0.01 St6gal1 NM_147205 -0.17 7.98E-10 St7l BF401641 -0.09 0.05 Stard7 XM_238280 0.06 3.26E-06 Stat1 NM_032612 0.06 0.05 Stat2 NM_001011905 0.06 0.03 Stbd1 NM_001013988 -0.16 1.22E-06 Stch NM_019271 -0.09 2.73E-03 Stip1 NM_138911 0.04 0.04 Stk10 ENSRNOT00000047011 -0.07 0.05 Stk19 NM_001013197 0.05 0.02 Stk4 BC088330 0.09 0.03 Stk40 NM_183056 0.08 1.10E-03 Stmn1 NM_017166 -0.1 5.39E-04 Stmn3 NM_024346 0.04 0.05 Stoml2 NM_001031646 0.04 0.01 Strap NM_001011969 -0.04 0.05 Strn NM_019148 -0.15 2.79E-03 Stx6 NM_031665 0.08 0.02 Suds3 CO574703 -0.06 0.02 Sumf1 ENSRNOT00000009008 0.06 8.49E-03 Surf6 NM_001015014 -0.11 8.98E-03 Suv420h1 ENSRNOT00000022486 -0.07 2.29E-03 Sv2a NM_057210 -0.27 1.26E-05 Syn1 NM_019133 0.08 0.03 Syngr1 g11378052 0.06 0.02 Page 81 of 288 Diabetes

Syngr4 NM_001025644 0.06 0.05 Synj1 NM_053476 -0.07 6.83E-05 Synj2bp NM_022599 -0.08 0.01 Synpo2 ENSRNOT00000019931 0.1 7.99E-03 Sytl2 BG670408 0.11 0.05 Sytl4 NM_080410 -0.06 0.03 Tacc2 NM_001004418 -0.06 0.02 Tacc3 NM_001004424 0.05 0.05 Taf1 ENSRNOT00000003494 -0.07 6.73E-04 Taf2 ENSRNOT00000040836 -0.07 7.86E-03 Tagln3 NM_001035236 0.1 9.16E-03 Tal2 ENSRNOT00000035687 0.09 0.05 Tarbp2 NM_001034941 -0.1 0.01 Tas1r2 AI103143 -0.1 0.04 Tbc1d10b ENSRNOT00000023706 0.08 6.50E-03 Tbc1d7 ENSRNOT00000019089 -0.2 1.47E-15 Tbx2 ENSRNOT00000004698 0.08 0.01 Tc2n NM_001025152 0.07 7.97E-04 Tcp11l2 NM_001017458 -0.09 0.02 Tctex1d2 ENSRNOT00000002397 -0.19 1.52E-05 Tdg NM_053729 -0.06 8.37E-03 Tdrd7 NM_138871 -0.37 2.42E-23 Tex15 ENSRNOT00000034325 0.08 0.01 Tex261 AI030736 -0.07 0.03 Tex264 NM_001007665 -0.19 1.67E-07 Tex9 ENSRNOT00000032268 0.07 5.83E-03 Tfb2m BQ203943 -0.11 7.89E-04 Tfip11 DQ342031 0.05 0.04 Tgfbr1 NM_012775 -0.14 3.42E-03 Tgoln1 NM_138840 -0.05 0.01 Tgs1 ENSRNOT00000010783 -0.12 0.03 Thoc1 NM_001047850 0.04 0.05 Thtpa NM_001007682 0.03 0.03 Timm10 NM_172074 -0.04 3.99E-03 Timm13 NM_145781 0.04 0.02 Timm8b NM_022541 0.05 5.14E-03 Timm9 ENSRNOT00000010871 -0.3 8.17E-26 Tipin NM_001025287 -0.06 7.21E-04 Tk1 g3710636 0.06 8.23E-03 Tlk1 BE115980 0.16 5.91E-04 Tloc1 NM_001034129 -0.12 5.90E-06 Tm2d3 ENSRNOT00000015287 0.06 0.02 Tm9sf2 NM_001005554 0.03 0.04 Tmco3 ENSRNOT00000026281 -0.04 0.01 Tmed1 NM_001013432 0.09 2.50E-03 Tmed9 NM_001009703 0.07 0.01 Tmem110 NM_198774 0.05 0.03 Diabetes Page 82 of 288

Tmem120a NM_001010945 0.07 0.01 Tmem123 NM_001014205 0.07 0.02 Tmem14a ENSRNOT00000037489 0.07 0.01 Tmem161b ENSRNOT00000045851 -0.15 8.39E-04 Tmem165 NM_001024802 0.04 1.53E-03 Tmem183a NM_001013871 -0.03 3.49E-03 Tmem188 ENSRNOT00000020816 0.08 0.03 Tmem189 703893835J1 0.08 5.64E-05 Tmem192 NM_001014141 -0.21 1.56E-16 Tmem2 ENSRNOT00000017212 -0.13 8.78E-06 Tmem209 NM_001014055 -0.09 5.63E-05 Tmem30a DV718956 -0.2 1.03E-14 Tmem34 NM_178330 0.05 5.43E-03 Tmem38b CV116450 0.06 0.04 Tmem49 NM_138839 0.05 0.03 Tmem55a NM_001024900 0.07 0.05 Tmem55b NM_001014233 -0.13 2.97E-03 Tmem56 704183920J1 0.06 0.01 Tmem87b ENSRNOT00000023569 0.07 0.04 Tmem9 ENSRNOT00000013738 -0.27 1.55E-24 Tmem93 ENSRNOT00000026168 -0.16 2.08E-15 Tmem97 NM_001008334 0.08 0.01 Tmod2 g3103039 -0.19 7.29E-05 Tmpo NM_012887 -0.08 1.87E-03 Tnfrsf12a NM_181086 0.1 2.29E-03 Tnfrsf21 ENSRNOT00000015918 0.07 0.04 Tnfsf15 NM_145765 0.11 0.03 Tnip1 XM_001073849 -0.07 1.09E-03 Tnks2 XM_001080123 0.07 0.02 Tob1 NM_133317 0.03 7.77E-03 Tob2 NM_001007146 0.13 0.01 Toe1 ENSRNOT00000024045 0.05 0.04 Tomm40b NM_001083338 0.11 0.04 Top1 CA945957 -0.06 0.02 Top3a XM_001077625 0.05 0.01 Tor1b NM_001039197 -0.17 1.55E-07 Tor3a NM_001009683 0.09 0.03 Tpcn1 NM_139332 0.16 3.30E-04 Tpd52 704155427J1 0.04 0.03 Tpd52l2 NM_198744 0.04 0.01 Tpr ENSRNOT00000003318 -0.07 9.72E-03 Traf3 ENSRNOT00000010906 0.05 0.03 Traf6 ENSRNOT00000006148 -0.25 9.09E-03 Traf7 ENSRNOT00000004192 -0.2 2.16E-12 Traip ENSRNOT00000052289 0.05 0.05 Tram1 EV768461 -0.06 7.10E-03 Trappc3 NM_001008376 0.05 0.04 Page 83 of 288 Diabetes

Trem2 ENSRNOT00000018351 0.07 0.01 Trhr NM_013047 0.09 0.05 Trib2 ENSRNOT00000005774 -0.1 0.04 Trim25 NM_001009536 -0.26 2.87E-10 Trim31 ENSRNOT00000061558 -0.05 0.04 Trim37 XM_001081108 -0.32 8.35E-26 Trim47_predicted ENSRNOT00000040703 -0.07 0.05 Trim66 ENSRNOT00000019368 -0.07 0.04 Trip11 ENSRNOT00000007061 0.06 0.04 Trp53bp2 BQ208445 0.04 0.04 Trp53inp1 AA946371 -0.07 0.04 Trpc2 g4293599 -0.07 0.04 Trub1 NM_001012173 -0.1 5.86E-06 Tsc22d3 NM_031345 -0.22 4.85E-07 Tsc22d4 BE120729 0.06 0.02 Tsen34 NM_001006968 -0.25 1.99E-14 Tsn NM_021762 -0.22 9.18E-09 Tsnaxip1 BF416541 0.08 0.05 Tspan12 NM_001015026 -0.13 5.59E-03 Tspan5 NM_001004090 0.04 0.03 Tspyl4 NM_001012075 0.1 3.49E-03 Tsta3 ENSRNOT00000012306 0.04 0.03 Ttc12 NM_001004246 -0.06 6.13E-03 Ttc5 NM_001013131 -0.07 0.01 Ttc7b ENSRNOT00000037902 -0.08 0.01 Ttk XM_001062174 0.06 0.04 Ttll6 ENSRNOT00000006594 0.08 0.02 Ttr NM_012681 -0.07 0.02 Ttyh3 ENSRNOT00000038773 -0.27 3.28E-10 Tuba1c NM_001011995 0.05 3.15E-03 Tubal3 ENSRNOT00000036821 0.11 0.01 Tubg1 NM_145778 0.04 0.04 Twist1 NM_053530 -0.23 2.19E-07 Twistnb XM_001076417 -0.19 1.80E-04 Txndc1 NM_001024800 -0.1 0.02 Txndc12 ENSRNOT00000010700 0.08 7.00E-06 Txndc15 NM_001024998 -0.11 8.57E-09 Txnl1 NM_080887 -0.05 0.04 Txnrd1 AF220761 -0.24 5.69E-03 U1snrnpbp NM_001014127 0.07 1.62E-03 Uba3 NM_057205 -0.05 0.03 Ubap2 ENSRNOT00000015920 0.05 0.04 Ube2a DN948071 -0.05 0.02 Ube2c ENSRNOT00000020323 0.03 0.02 Ube2d1 XM_001080152 -0.1 1.49E-04 Ube2d3 ENSRNOT00000051335 -0.23 1.04E-14 Ube2e2 BC079134 0.04 0.01 Diabetes Page 84 of 288

Ube2f NM_001008381 0.04 0.02 Ube2j1 g14926612 0.07 0.01 Ube2j2 NM_001007655 0.04 0.05 Ube2n NM_053928 0.06 0.03 Ube2q1 ENSRNOT00000028210 0.11 2.63E-06 Ube2t ENSRNOT00000006747 0.07 6.09E-06 Ube2v2 NM_183052 -0.11 1.30E-03 Ube4b XM_233679 0.07 8.18E-03 Ubl4 ENSRNOT00000056313 0.09 0.03 Ublcp1 NM_001014117 0.07 0.02 Ubp1 ENSRNOT00000013050 -0.07 0.04 Ubqln4 ENSRNOT00000026994 0.06 0.04 Ufm1 ENSRNOT00000058116 0.06 0.05 Ufsp2 NM_001014142 0.05 0.05 Ugp2 NM_001024743 0.05 0.01 Uhrf1 NM_001008882 -0.05 3.46E-03 Unc119b EV778603 0.05 0.02 Usp14 NM_001008301 -0.07 2.07E-03 Usp28 XM_001070037 0.06 0.05 Usp31 ENSRNOT00000052246 0.07 0.02 Usp32 DV724644 0.05 0.01 Usp38 ENSRNOT00000035084 0.07 6.66E-07 Usp39 ENSRNOT00000015562 0.07 3.83E-03 Usp9x CK839458 -0.11 4.50E-03 Uspl1 ENSRNOT00000001210 0.06 0.04 Utp3 NM_001012036 0.05 0.03 Uxs1 NM_139336 0.08 3.72E-03 Vamp3 NM_057097 0.08 7.70E-03 Vasp ENSRNOT00000022214 -0.11 9.12E-03 Vcl XM_223781 0.1 2.34E-03 Vcpip1 NM_176857 0.06 3.90E-04 Vdac2 NM_031354 -0.14 4.48E-06 Vegfa NM_031836 -0.15 3.35E-03 Vegfc NM_053653 0.13 8.26E-03 Vgll4 BF545269 -0.14 0.01 Vill ENSRNOT00000015888 0.07 0.02 Visa NM_001005556 0.09 0.03 Vkorc1l1 NM_203338 0.04 0.01 Vps26a NM_001007740 0.09 6.33E-05 Vps36 ENSRNOT00000016995 0.05 7.24E-03 Vps37a NM_001024867 -0.06 5.36E-04 Vps37b ENSRNOT00000001445 -0.18 2.45E-04 Vps45 NM_172072 0.04 0.02 Vps52 CR470235 -0.13 0.01 Vrk1 NM_001012194 -0.18 1.01E-11 Vsnl1 NM_012686 0.08 0.04 Wbp11 NM_001009661 0.06 8.23E-03 Page 85 of 288 Diabetes

Wbscr18 703948844J1 0.04 0.05 Wdfy1 NM_001008331 -0.09 0.01 Wdr22 BC079428 0.08 0.01 Wdr33 CD371333 0.13 1.21E-04 Wdr47 ENSRNOT00000027558 -0.11 1.75E-04 Wdr55 NM_001017932 0.06 0.04 Wdr74 CK841336 0.07 9.99E-03 Wdr88 ENSRNOT00000056584 0.08 0.05 Wdr91 ENSRNOT00000014010 -0.09 1.91E-03 Wdsof1 ENSRNOT00000005803 0.04 9.27E-03 NM_001012742 0.06 1.62E-04 Wfs1 NM_031823 0.13 0.02 Wrb NM_199373 -0.31 1.40E-45 Wwp2 XM_001076615 -0.14 2.85E-04 Xkr8 NM_001012099 0.19 5.04E-04 Xpa ENSRNOT00000012779 -0.13 0.05 Xpnpep1 NM_131913 0.03 0.02 Xpnpep2 NM_057155 0.07 3.82E-03 Xpot DV719825 -0.11 3.90E-03 Yars2 NM_001009627 0.05 0.03 Yipf1 BQ204057 -0.11 0.05 Yipf5 NM_001014150 0.05 7.55E-03 Yrdc NM_175604 -0.15 3.04E-10 Ythdc2 XM_225959 -0.05 5.23E-04 Ythdf1 NM_001024756 0.05 8.38E-03 Ywhag NM_019376 -0.07 4.83E-03 Zbed3 NM_001025729 0.08 9.58E-04 Zbtb1 NM_001004444 -0.12 1.23E-03 Zbtb17 NM_001012105 -0.09 3.13E-03 Zbtb20 703080592T1 -0.17 5.29E-16 Zbtb44 NM_001034942 -0.3 2.45E-09 Zbtb9 NM_213564 0.06 5.52E-03 Zc3h13 704221578H1 0.12 0.01 Zc3h15 NM_001010963 0.05 0.03 Zcchc11 XM_001060286 -0.09 1.09E-03 Zcchc3 ENSRNOT00000009859 0.08 0.03 Zdhhc12 NM_001013239 0.1 1.41E-03 Zdhhc15 NM_001039101 0.11 0.02 Zdhhc16 NM_001039346 0.07 5.15E-04 Zdhhc19 NM_001039259 0.06 0.01 Zdhhc20 NM_001039336 -0.13 0.04 Zdhhc4 NM_001013123 0.06 5.41E-05 Zdhhc5 NM_001039338 0.05 0.04 Zdhhc6 NM_001037652 -0.1 7.86E-04 Zeb2 NM_001033701 0.06 0.05 Zfand1 ENSRNOT00000013905 0.11 0.05 Zfp110 NM_001024775 0.1 8.68E-03 Diabetes Page 86 of 288

Zfp167 BC061851 -0.12 0.04 Zfp202 ENSRNOT00000009059 -0.08 0.02 Zfp238 NM_022678 -0.17 5.34E-07 Zfp329 g4400386 0.17 7.67E-03 Zfp364 ENSRNOT00000000110 0.05 0.04 Zfp385c ENSRNOT00000032737 0.1 8.09E-03 Zfp386 NM_019620 0.05 0.03 Zfp395 ENSRNOT00000019034 0.11 3.82E-03 Zfp40 ENSRNOT00000015520 0.06 0.04 Zfp445 ENSRNOT00000034690 0.15 7.94E-03 Zfp593 ENSRNOT00000021937 0.07 4.34E-03 Zfp644 ENSRNOT00000002882 -0.08 2.58E-03 Zfp655 NM_001008362 0.05 0.04 Zfp667 NM_001008557 0.06 0.01 Zfp710 BQ204360 0.06 0.01 Zfp828 ENSRNOT00000000124 0.06 9.11E-03 Zfp91 ENSRNOT00000016804 0.12 0.02 Zfyve27 NM_199104 -0.11 5.14E-03 Zhx1 NM_133620 -0.28 2.86E-10 Zmym2 ENSRNOT00000011684 -0.1 6.06E-04 Zmynd10 NM_001004284 0.06 0.01 Znrf1 ENSRNOT00000051594 -0.11 0.03 Zswim1_predicted XM_230846 0.09 1.94E-09 Zswim6 XM_001073593 -0.11 5.18E-04 Zyg11b ENSRNOT00000014436 0.06 0.02 Zzef1 AW251798 0.08 0.02 CA505073 -0.54 5.06E-24 Page 87 of 288 Diabetes

mRNAs colored red contain seed region against both miRNA-132 and 212 Diabetes Page 88 of 288

Gene Symbol Accession Number Log(Ratio) P-value March2 AB048838 -0.09 0.000697 mRNAs colored red contain seed region against both miRNA-132 and 212 39877 CB797262 0.07 0.000172 40067 703880893J1 -0.14 0.00106 Aacs NM_023104 -0.17 7.95E-21 Aadat CR466784 -0.09 0.04 Aamp ENSRNOT00000019497 -0.06 0.00307 Aars ENSRNOT00000025052 -0.05 0.02 Aasdh XM_344230 -0.08 0.02 Aasdhppt ENSRNOT00000008062 0.05 0.03 Abcb8 NM_001007796 -0.06 0.04 Abcf1 CK359266 0.07 0.03 Abhd10 g8495343 0.12 0.00062 Abhd13 CX570069 0.09 0.00000698 Abhd3 ENSRNOT00000041878 0.06 0.05 Abl1 ENSRNOT00000042495 -0.21 3.41E-08 Abp1 CV120190 0.13 0.00255 Abr ENSRNOT00000032861 -0.2 0.000373 Abt1 ENSRNOT00000023649 0.05 0.02 Acad9 BF406274 -0.19 3E-10 Acadm NM_016986 0.05 0.00707 Ace2 NM_001012006 0.13 0.04 Acly EV776653 -0.07 0.000584 Acot3 ENSRNOT00000051235 0.06 0.01 Acp2 NM_016988 0.05 0.04 Acsl4 NM_053623 -0.4 2.57E-37 Actr2 g8501150 -0.49 3.92E-32 Actr3 NM_031068 -0.15 9.69E-08 Actr3b ENSRNOT00000050686 -0.19 0.00000542 Actr6 XM_001076791 -0.41 0 Actr8 ENSRNOT00000020750 -0.16 8.31E-13 Acvr2b NM_031554 -0.14 0.01 Adam9 NM_001014772 0.07 0.00409 Adamts12 ENSRNOT00000025693 0.09 0.00823 Adamts6 704305148J1 0.08 0.00386 Adamts7 NM_001047101 -0.05 0.04 Adcy6 NM_012821 -0.15 0.00000423 Adipor1 BQ208259 0.05 0.02 Adipor2 ENSRNOT00000010556 -0.07 0.00106 Adnp NM_022681 -0.08 0.04 Ado ENSRNOT00000000791 0.08 0.0053 Adpgk ENSRNOT00000013022 0.08 0.0034 Afp NM_012493 -0.06 0.05 Aftph CA505662 -0.06 0.03 Agpat3 703889388J1 0.16 0.04 Aifm1 NM_031356 0.09 2.26E-09 Aifm2 ENSRNOT00000035982 0.18 0.000932 Page 89 of 288 Diabetes

Aig1 AI231309 -0.23 1.3E-11 Akap10_predicted ENSRNOT00000003871 -0.09 0.00381 Akap4 NM_024402 0.06 0.04 Akr1cl1 ENSRNOT00000058312 -0.07 0.05 Aldh1l2 g3291417 -0.29 9.98E-12 Alg10b NM_139101 0.07 0.02 Alg11 ENSRNOT00000017164 0.04 0.01 Alg5 NM_001025407 0.06 0.00681 Alpi NM_022665 0.09 0.01 Als2 XM_001061827 -0.11 7.64E-15 Als2cl 703111359J1 0.08 0.03 Als2cr4 ENSRNOT00000031858 0.05 0.04 Amd1 CK839427 -0.05 0.01 Anapc7 XM_001079480 -0.08 0.02 Angel2 ENSRNOT00000005084 -0.07 0.00789 Ankib1 BI296171 0.08 0.0056 Ankmy2 ENSRNOT00000007562 0.07 0.01 Ankrd10 CO566009 -0.06 0.03 Ankrd12 ENSRNOT00000017613 -0.08 0.02 Ankrd49 XM_001069095 -0.11 0.03 Ankrd56 BF394727 0.07 0.00451 Ankrd6 XM_001056902 0.08 0.02 Anp32a CB696160 -0.51 2.99E-13 Anp32b NM_131911 -0.06 0.000145 Anxa4 NM_024155 -0.32 4.6E-09 Ap1g1 ENSRNOT00000051859 0.05 0.00209 Ap3b1 ENSRNOT00000014278 0.06 0.02 Ap3m1 NM_133593 -0.05 0.02 Apba1 g8486477 0.07 0.01 Apc g4465574 0.04 0.04 Apex1 NM_024148 0.03 0.02 Aph1b NM_001047090 -0.07 0.02 Api5 DQ480749 0.07 0.00309 Aplp2 M31322 -0.09 0.01 Appbp2 g11659913 -0.22 2.3E-21 Appl2 ENSRNOT00000010986 -0.07 0.04 Araf NM_001033663 -0.05 0.02 Arf2 NM_024150 -0.1 0.000014 Arf4 NM_024151 0.03 0.00264 Arfrp1 NM_053980 -0.11 0.0000271 Arhgef11 704289575J1 -0.09 0.00206 Arhgef15 ENSRNOT00000006149 0.07 0.00197 Arhgef9 NM_023957 -0.13 0.00657 Arid1a ENSRNOT00000009173 -0.13 0.00222 Arid3b XM_001074513 0.08 0.05 Arid4b NM_053421 -0.18 0.0000187 Arih1 703829854J1 -0.17 2.38E-08 Diabetes Page 90 of 288

Arl3 NM_022700 0.03 0.03 Arl8b NM_001024332 0.04 0.02 Armcx2 NM_001014274 0.07 0.00221 Armcx3 NM_001014273 -0.11 0.0000481 Arpc1b NM_019289 0.04 0.03 Arpc5 NM_001025717 0.05 0.01 Art3 AJ291433 0.09 0.03 Asahl NM_001010967 0.08 0.00293 Asb1 ENSRNOT00000027528 0.08 0.01 Asf1b ENSRNOT00000006964 0.05 0.01 Atad3a NM_001034922 0.06 0.01 Atg12 NM_001038495 -0.2 8.71E-22 Atp2a2 ENSRNOT00000024347 0.06 0.05 Atp4a ENSRNOT00000028508 0.09 0.04 Atp5g3 NM_053756 -0.28 4.54E-32 Atp6v0c NM_130823 -0.07 0.0085 Atp6v1a1 ENSRNOT00000002727 -0.2 0.000000269 Atpaf1 CK838935 -0.12 0.00275 Atpbd1c NM_201991 0.07 0.01 Atrx DV714531 -0.11 0.000507 Atxn7 ENSRNOT00000010103 -0.11 0.02 Auh ENSRNOT00000015786 0.05 0.02 Aurka ENSRNOT00000006323 -0.28 2.26E-29 Aurkb NM_053749 0.05 0.02 Avpi1 NM_134373 0.07 0.01 Azin1 NM_022585 -0.15 5.06E-15 B3galnt1 NM_001013158 0.06 0.000948 B3galt4 NM_133553 0.06 0.02 B3gnt6 ENSRNOT00000046850 0.08 0.05 B4galt3 NM_001009539 -0.09 0.000167 Bad NM_022698 0.05 0.00619 Bcar3 ENSRNOT00000018417 -0.12 0.02 Bcas2 ENSRNOT00000025592 -0.39 0 Bckdhb ENSRNOT00000013249 0.06 0.02 Bckdk BQ782172 -0.16 1.5E-26 Bcl10 NM_031328 0.06 0.0000172 Bdh1 NM_053995 0.09 0.000721 Bdp1 ENSRNOT00000024023 -0.19 0.00375 Bfar NM_001013125 -0.11 0.0000473 Bhlhb2 704274088J1 -0.17 0.00000223 Bhlhb3 NM_133303 -0.15 0.03 Blcap NM_133582 0.08 0.000792 Bles03 NM_001024233 0.12 0.00279 Blmh NM_001034163 0.06 0.000262 Bloc1s2 NM_001037349 -0.05 0.00712 Bmp4 NM_012827 -0.07 0.04 Bmp6 BF387416 0.05 0.05 Page 91 of 288 Diabetes

Bmyc NM_001013163 0.05 0.0041 Bnip2 BF282292 -0.22 5.49E-08 Boc BQ781165 0.05 0.04 Bola3 ENSRNOT00000031583 0.06 0.00169 Bpgm EV764831 0.05 0.04 Brca1 NM_012514 -0.1 0.00124 Brd4 ENSRNOT00000060345 0.08 0.03 Brd8 NM_001008509 -0.05 0.03 Bri3 NM_001009604 -0.28 1.82E-22 Brp44l NM_133561 0.05 0.0026 Bscl2 NM_001012171 0.04 0.02 Btbd3 704154689J1 0.06 0.01 Btg2 NM_017259 -0.3 0.000000532 Btg3 NM_019290 0.04 0.000685 Bub3 701233686F7 -0.04 0.04 Bxdc2 NM_001029915 0.05 0.01 Bysl NM_182674 0.05 0.02 Bzrap1 ENSRNOT00000046668 0.05 0.02 Bzw1 704294868J1 0.08 0.000141 C11orf8h NM_198778 -0.07 0.00082 Cables2 ENSRNOT00000008279 -0.1 0.00248 Cacna1a g4399241 -0.09 0.00221 Cacna1e AF009419 0.06 0.03 Cacna1h NM_153814 -0.07 0.02 Cacna1i AY128644 0.12 0.03 Cacnb2 NM_053851 -0.13 0.000000405 Cadm4 XM_001076576 0.04 0.02 Cadps NM_013219 -0.17 2.37E-15 Calu NM_001033898 -0.19 0.0000165 Capn2 NM_017116 -0.12 0.00058 Card6 ENSRNOT00000039057 0.04 0.01 Casc4 ENSRNOT00000038291 -0.18 0.00807 Casp3 NM_012922 -0.15 0.00305 Cat NM_012520 -0.06 0.01 Cbll1 ENSRNOT00000009566 -0.06 0.02 Cbx1 XM_001081346 -0.21 0.00000299 Cbx6 NM_001012119 0.08 0.03 Cbx7 NM_199117 0.06 0.03 Ccdc107 ENSRNOT00000023411 0.08 0.00435 Ccdc117 CF112977 -0.23 2.22E-08 Ccdc127 BP500928 0.06 0.04 Ccdc23 NM_001038992 0.05 0.04 Ccdc32 NM_001024245 0.07 0.03 Ccdc43 ENSRNOT00000003685 0.08 0.00582 Ccdc59 ENSRNOT00000005740 -0.12 0.000107 Ccl22 NM_057203 0.07 0.00144 Ccna2 NM_053702 0.07 0.000189 Diabetes Page 92 of 288

Ccnb2 NM_001009470 0.06 0.01 Ccnc AA998893 -0.27 0.03 Ccnd3 NM_012766 0.12 0.04 Ccne1 ENSRNOT00000020014 0.05 0.00415 Ccng1 NM_012923 -0.15 0.00335 Ccnyl1 704291233J1 0.13 0.03 Cd1d1 NM_017079 -0.19 2.05E-08 Cd200 NM_031518 0.1 0.0000243 Cd276 NM_182824 0.07 0.00208 Cd300lf NM_001025111 -0.12 0.04 Cd55 NM_022269 0.06 0.05 Cd99l2 NM_134459 0.06 0.00705 Cdc23 ENSRNOT00000037888 0.07 0.00261 Cdc27 BI299689 -0.12 0.000123 Cdc2l6 g14960432 -0.14 0.01 Cdc34 NM_001013103 0.09 0.000866 Cdc37l1 NM_001011941 -0.14 3.38E-08 Cdc40 XM_342154 -0.27 8.5E-24 Cdc42ep4 ENSRNOT00000048264 -0.18 0.00000995 Cdc45l XM_001061676 -0.07 0.03 Cdca3 NM_001007648 0.04 0.00759 Cdh1 NM_031334 -0.12 0.000111 Cdipt NM_138899 0.05 0.04 Cdkn1a DN947728 -0.27 0.02 Cdkn2aipnl NM_001008278 0.04 0.03 Cdo1 NM_052809 0.1 0.000586 Cdw92 BM391692 0.08 0.00288 Cebpz ENSRNOT00000006824 -0.19 0.000118 Cenpn ENSRNOT00000058752 -0.07 0.03 Cep55 NM_001025646 0.09 0.00331 Cep68 ENSRNOT00000039523 0.05 0.05 Cep70 NM_001017470 -0.08 0.01 Cerk ENSRNOT00000022882 -0.11 0.00385 Cetn3 ENSRNOT00000021735 -0.07 0.00183 Cfl2 XM_001079054 0.08 0.0018 Cgrrf1 NM_053899 0.07 0.02 Chchd1 ENSRNOT00000012372 0.04 0.000105 Chchd8 ENSRNOT00000038764 0.05 0.02 Chd4 CB322822 0.06 0.00219 Chd6 ENSRNOT00000022861 -0.14 0.000000661 Chek2 NM_053677 -0.04 0.04 Chid1 NM_001047854 0.05 0.04 Chmp2b XM_001063932 -0.1 0.00000161 Chrnb2 NM_019297 0.1 0.03 Chst13 ENSRNOT00000029915 0.11 0.000677 Chsy1_predicted ENSRNOT00000016939 -0.11 0.000231 Ciapin1 NM_001007689 0.06 0.0000627 Page 93 of 288 Diabetes

Cib4 ENSRNOT00000013123 0.1 0.04 Cideb ENSRNOT00000027612 0.09 0.05 Cinp BC097975 0.05 0.03 Cirbp NM_031147 -0.27 1.83E-12 Cirh1a NM_001009640 0.06 0.0000492 Cldn4 NM_001012022 -0.09 0.00714 Cldnd1 NM_001006955 0.06 0.01 Clec5a ENSRNOT00000033265 0.07 0.03 Clip1 DY319638 0.17 0.04 Clp1 NM_001009599 0.08 0.00459 Clpp XM_217313 0.04 0.02 Cmpk2 ENSRNOT00000052003 0.08 0.04 Cmtm4 702082415F6 -0.34 6.07E-11 Cndp2 NM_001010920 0.06 0.02 Cnih ENSRNOT00000013331 -0.16 1.33E-16 Cnn3 NM_019359 0.06 0.00791 Cno 704149177J1 -0.13 9.02E-08 Cnot6 704227082H1 -0.19 0.0000492 Cnot7 ENSRNOT00000016882 -0.17 2.49E-14 Cnr1 ENSRNOT00000010850 -0.15 0.00868 Cntnap1 NM_032061 0.09 0.04 Col16a1 ENSRNOT00000045413 0.05 0.01 Col4a1 ENSRNOT00000057386 0.08 0.04 Commd2 ENSRNOT00000022778 -0.11 0.00000281 Commd8 XM_001069497 0.12 0.000132 Cops7b XM_343614 0.06 0.02 Cops8 NM_001013227 0.06 0.00279 Coq10b NM_001009671 -0.16 0.00000766 Coq3 NM_019187 0.15 7.6E-09 Coq5 NM_001039022 0.06 0.03 Coro1a NM_130411 0.07 0.00222 Cox15 NM_001033699 0.04 0.04 Cox19 ENSRNOT00000001735 0.04 0.02 Cplx1 NM_022864 0.09 0.000829 Cpne8 XM_001056316 -0.14 0.000000568 Cpox NM_001037095 0.16 6.57E-09 Cpsf6 702957586J1 -0.11 0.02 Crb3 NM_001025661 0.06 0.01 Creg1 BF282301 0.11 0.00138 Crem NM_013086 0.15 0.00691 Crhr1 NM_030999 -0.08 0.000114 Crop ENSRNOT00000003914 -0.14 0.03 Crot NM_031987 0.14 0.0000201 Csde1 NM_054006 -0.16 8.03E-14 Cse1l ENSRNOT00000010210 -0.14 1.4E-14 Csf1 NM_023981 0.09 0.02 Csf1r BI288375 -0.08 0.02 Diabetes Page 94 of 288

Csgalnact1 XM_001070654 0.05 0.04 Cspg5 NM_133652 -0.11 0.00756 Csrp1 NM_017148 0.04 0.03 Ctage5 ENSRNOT00000006995 0.06 0.04 Ctbs NM_031023 -0.08 0.04 Ctdspl2 703829205J1 -0.13 0.00212 Ctnnbip1 ENSRNOT00000055562 0.09 0.00985 Ctsf NM_001034110 -0.05 0.05 Cttnbp2nl ENSRNOT00000019680 -0.09 0.02 Cul2 ENSRNOT00000045970 0.06 0.04 Cul4b XM_001058651 -0.1 0.0025 Cwc15 NM_001024987 0.06 0.02 Cxcl11 NM_182952 -0.12 0.0000495 Cxcr7 NM_053352 -0.08 0.03 Cxxc5 BI281838 -0.08 0.01 Cyb561d1 ENSRNOT00000040396 0.14 0.05 Cyb5r4 ENSRNOT00000013975 -0.07 0.00973 Cyc1 ENSRNOT00000017067 0.04 0.03 Cyld ENSRNOT00000060789 -0.28 8.43E-25 Daam1 ENSRNOT00000005927 -0.26 4.94E-08 Dazap2 NM_001013107 -0.56 0 Dbc1 NM_080482 0.07 0.04 Dbp NM_012543 -0.04 0.05 Dbt ENSRNOT00000020267 0.07 0.05 Dcbld1 ENSRNOT00000000462 0.19 0.0083 Dclk1 NM_053343 -0.22 2.6E-13 Dcp1a XM_001063126 0.09 0.02 Dctd NM_001013882 -0.04 0.01 Dcun1d1 XM_001067883 -0.19 0.01 Dcun1d4 703969008J1 -0.12 0.03 Ddc BI288867 -0.05 0.03 Ddn NM_030993 0.04 0.03 Ddx3x BC085914 0.04 0.05 Ddx52 NM_053525 0.04 0.04 Ddx56 NM_001004211 0.06 0.000632 Def8 NM_001024774 -0.24 7.32E-12 Degs1 NM_053323 -0.26 9.43E-22 Dek NM_001004255 -0.18 5.58E-18 Dennd1b ENSRNOT00000043907 -0.35 2.58E-16 Depdc1a XM_001080406 0.07 0.0000419 Det1 NM_001037194 0.06 0.02 Dexi ENSRNOT00000003544 -0.12 0.00000486 Dffa NM_053679 0.1 0.000245 Dgat2 NM_001012345 0.07 0.02 Dgcr8 ENSRNOT00000002581 -0.09 0.0000406 Dgkg NM_013126 0.08 0.00467 Dguok ENSRNOT00000015526 -0.09 0.0046 Page 95 of 288 Diabetes

Dhcr24 ENSRNOT00000009402 -0.18 3.25E-40 Dhtkd1 NM_001025720 0.09 0.02 Dhx37 ENSRNOT00000030823 -0.13 0.000346 Dhx8 NM_001047844 0.07 0.000115 Dicer1 703990879J1 -0.11 0.000000256 Dixdc1 NM_001037654 -0.28 2.81E-13 Dlat 702385582H1 0.06 0.03 Dlc1 XM_001066332 -0.1 0.02 Dlg2 NM_022282 0.08 0.05 Dll1 NM_032063 -0.09 0.00311 Dnahc2 ENSRNOT00000029496 0.06 0.04 Dnaja1 NM_022934 -0.05 0.04 Dnaja2 NM_032079 -0.18 3.94E-14 Dnajb1 CB718513 0.06 0.04 Dnajb14 BQ781541 -0.17 0.00000289 Dnajc15 ENSRNOT00000012530 0.05 0.00703 Dnajc18 NM_001013887 0.07 0.04 Dnajc21 AI717315 0.08 0.01 Dnalc4 NM_001009666 0.06 0.02 Dnali1 NM_001031647 0.12 0.00157 Dnmt3l NM_001003964 0.14 0.0000327 Dock9 X68101 -0.07 0.000625 Dohh NM_001025006 0.04 0.02 Dolk ENSRNOT00000022786 0.04 0.02 Donson NM_001008287 -0.11 0.00468 Dph4 XM_342483 0.11 0.00135 Dpysl3 704297194J1 -0.47 0 Dr1 NM_001011914 -0.11 6.42E-11 Dsc2 NM_001033688 -0.12 0.000238 Dse ENSRNOT00000001093 -0.23 4.1E-11 Dusp11 NM_001025650 -0.19 0.000000284 Dusp12 NM_022248 -0.13 0.02 Dusp18 NM_001013128 -0.07 0.02 Dusp22 ENSRNOT00000024587 -0.13 3.01E-10 Dync1i1 NM_019234 0.04 0.05 Dynlt3 NM_001013228 0.08 0.0000333 Dyrk2 ENSRNOT00000010283 -0.16 0.000145 E2f5 ENSRNOT00000014361 -0.07 0.05 Ebna1bp2 NM_001008721 0.04 0.02 Ebp NM_057137 0.05 0.03 Ece2 AI229953 0.09 0.00924 Eea1 ENSRNOT00000029764 0.09 0.0013 Eef1a1 DV723221 -0.29 3.03E-37 Eef1e1 CF977307 -0.06 0.02 Efhd2 NM_001031648 0.08 0.000231 Efna4 ENSRNOT00000027935 -0.12 0.00316 Efnb2 g6160381 -0.1 0.05 Diabetes Page 96 of 288

Efr3a DY471847 -0.22 2.06E-13 Ehbp1 ENSRNOT00000012131 -0.13 0.0000875 Ehmt2 NM_212463 -0.14 0.00676 Eid1 XM_001077667 -0.06 0.00656 Eif1a NM_001008773 -0.14 3.61E-08 Eif1ad NM_001008305 0.17 0.00000465 Eif2ak2 NM_019335 -0.09 0.00982 Eif2ak3 NM_031599 -0.09 0.05 Eif2b1 NM_172029 0.04 0.00606 Eif2b3 NM_133609 -0.05 0.02 Eif2b5 U19516 0.07 0.000438 Eif2c1 XM_233544 -0.08 0.04 Eif3g NM_001013095 0.03 0.03 Eif3h NM_198751 -0.11 0.00000058 Eif4a2 NM_001008335 -0.06 0.00159 Eif4enif1 ENSRNOT00000024993 -0.1 0.000193 Eif5a2 ENSRNOT00000015779 -0.19 0.000443 Eif6 NM_001037352 0.04 0.00958 Ela3b ENSRNOT00000036788 0.06 0.02 Ell ENSRNOT00000026846 0.05 0.04 Ell2 ENSRNOT00000032974 0.08 0.02 Elovl4 XM_001062735 0.09 0.01 Elovl6 NM_134383 0.07 0.0000179 Elovl7 XM_342192 0.08 0.00201 Eml5 ENSRNOT00000005978 -0.08 0.00633 Enc1 NM_001003401 -0.27 0.00193 Entpd5 NM_199394 -0.07 0.00657 Entpd6 NM_053498 0.09 0.00234 Ep300 ENSRNOT00000000206 -0.13 0.000571 Ep400 ENSRNOT00000056736 -0.07 0.03 Epb4.1l4a ENSRNOT00000038247 -0.12 0.04 Ephb2 ENSRNOT00000016983 0.05 0.03 Ephb6 ENSRNOT00000019720 0.11 0.00714 Epn2 NM_021852 -0.27 0 Eps8 703959071J1 -0.16 4.06E-13 Ercc8 ENSRNOT00000013598 0.04 0.00898 Erg NM_133397 -0.08 0.02 Ero1l BC071175 0.13 0.00000446 Ero1lb ENSRNOT00000003526 -0.39 0.00194 Esd ENSRNOT00000013324 0.05 0.02 Ethe1 ENSRNOT00000027075 0.08 0.03 Etnk1 BC089927 -0.21 2.95E-20 Etv1 700525503F6 -0.31 7.52E-10 Evi1 XM_226987 -0.09 0.000487 Exoc5 NM_022204 -0.18 0.000000452 Exosc4 ENSRNOT00000016464 0.05 0.04 Exosc5 ENSRNOT00000028026 0.07 0.00441 Page 97 of 288 Diabetes

Exosc7 ENSRNOT00000005975 -0.09 0.000335 Extl3 NM_020097 -0.11 0.02 F11r NM_053796 -0.16 0.00000172 F2r NM_012950 -0.08 0.000318 Fam122a NM_001014029 0.06 0.000518 Fam128b ENSRNOT00000002511 0.08 0.01 Fam152b BE112735 0.08 0.000183 Fam20b g4252561 -0.06 0.02 Fam44b NM_001013854 0.06 0.03 Fam45a ENSRNOT00000013845 0.08 0.00219 Fam54b NM_001013935 0.06 0.00302 Fam58b NM_001025412 0.07 0.01 Fam69a ENSRNOT00000030479 0.09 0.02 Fam98b 704322467J1 -0.07 0.01 Fancb ENSRNOT00000004456 -0.06 0.04 Fancl XM_223701 0.1 0.000227 Farp1 CK843176 -0.12 0.0021 Fblim1 NM_001007554 -0.04 0.02 Fbln1 BQ206879 0.05 0.04 Fbxl19 ENSRNOT00000049576 0.08 0.01 Fbxo21 ENSRNOT00000001491 -0.14 0.03 Fbxo22 NM_001037770 -0.21 1.92E-09 Fbxo43 ENSRNOT00000014333 -0.08 0.02 Fech ENSRNOT00000059188 0.07 0.00121 Fermt2 NM_001011915 -0.16 2.58E-09 Fermt3 XM_001076361 -0.14 0.03 Fes BC088336 -0.07 0.04 Fgd2 ENSRNOT00000041665 0.08 0.01 Fgf11 NM_130816 -0.08 0.04 Fgf14 ENSRNOT00000012788 0.06 0.04 Fgfr1op2 NM_201421 0.07 0.00111 Fgl2 NM_053455 -0.36 0.0000924 Fh1 NM_017005 0.06 0.01 Fis1 ENSRNOT00000001924 -0.05 0.04 Fjx1 ENSRNOT00000007077 0.12 0.0000057 Fkbp2 ENSRNOT00000028725 -0.25 3.24E-24 Fkrp NM_001025678 0.11 0.00000183 Fmo3 NM_053433 0.06 0.03 Fnbp1l NM_001039609 -0.24 0.000478 Fndc3a AI599269 0.09 0.02 Foxm1 NM_031633 0.06 0.00847 Foxn3 ENSRNOT00000006604 -0.12 0.02 Foxo3a ENSRNOT00000000327 -0.11 0.03 Foxp2 g8512175 -0.13 0.00468 Frmd8 NM_001008348 -0.09 0.02 Fstl1 BG672610 0.15 0.000402 Fubp3 703973695J1 -0.09 0.0000247 Diabetes Page 98 of 288

Fusip1 NM_001025738 -0.2 0.00011 Fut8 NM_001002289 0.09 0.00218 Fxr1 BC099129 0.12 0.00000135 Fyb ENSRNOT00000018634 0.08 0.04 Fyttd1 XM_001081958 -0.16 3.67E-17 G0s2 NM_001009632 -0.41 0.0000115 G3bp1 704304832H1 -0.06 0.000388 Gab2 NM_053417 -0.05 0.04 Gabrd NM_017289 0.12 0.03 Gabre AF255612 0.08 0.02 Gadd45g NM_001077640 -0.13 0.03 Galm NM_001007704 0.07 0.02 Galnt7 BF397407 0.12 0.05 Gap43 NM_017195 0.05 0.00173 Gatad1 ENSRNOT00000061122 0.05 0.03 Gatm NM_031031 0.12 0.00111 Gbf1 CK226550 0.14 0.00353 Gck NM_012565 -0.08 0.01 Gcs1 NM_031749 0.06 0.02 Gda NM_031776 0.08 0.00244 Gemin4 XM_001080744 0.08 0.02 Gen1 ENSRNOT00000006470 -0.09 0.0013 Gfm2 BC091392 -0.11 2.9E-11 Gfra1 NM_012959 -0.06 0.00801 Gimap1 NM_001034849 0.06 0.05 Git2 CV797035 -0.08 0.04 Gja3 NM_024376 0.07 0.03 Gkn2 NM_001039686 0.1 0.00222 Gla XM_001068735 0.12 0.03 Glrx5 ENSRNOT00000005781 0.03 0.00133 Glt8d3 ENSRNOT00000006960 0.1 0.01 Glul NM_017073 -0.05 0.04 Gmcl1 NM_001033931 0.1 0.0000293 Gna14 NM_001013151 0.1 0.00426 Gnai3 NM_013106 -0.18 2.62E-24 Gnb1 ENSRNOT00000022649 -0.27 0.000151 Gng10 NM_053660 0.04 0.03 Gnptab ENSRNOT00000006946 0.07 0.000425 Gns ENSRNOT00000006566 0.05 0.01 Golga4 CR460271 0.08 0.03 Golim4 ENSRNOT00000037115 0.06 0.01 Gosr2 NM_031685 -0.11 5.22E-14 Got1 NM_012571 0.04 0.00633 Gpbp1 ENSRNOT00000036658 0.06 0.000825 Gpd2 NM_012736 -0.17 0.01 Gpm6a CB782138 0.12 0.04 Gpr137b ENSRNOT00000003503 0.14 0.0000284 Page 99 of 288 Diabetes

Gpr180 NM_001006994 0.07 0.00976 Gpr27 NM_023099 -0.19 0.000999 Gpr3 NM_153727 0.08 0.02 Gpr37 NM_057201 0.1 0.02 Gpr56 NM_152242 -0.07 0.04 Gpr85 NM_022254 0.13 0.00949 Gprasp2 ENSRNOT00000004260 0.05 0.04 Gria3 NM_032990 -0.1 0.00236 Grin1 NM_017010 0.08 0.000317 Grinl1a NM_183402 -0.04 0.03 Gspt2 XM_001057027 0.09 0.000000211 Gstm4 NM_020540 0.06 0.02 Gtf2b NM_031041 0.05 0.00468 Gtf2e1 ENSRNOT00000003513 0.06 0.03 Gtf2h1 BQ211767 -0.11 0.00856 Gtf3c3 ENSRNOT00000002864 -0.12 0.000194 Gtl3 NM_001037978 0.05 0.05 Gucy1b3 NM_012769 0.06 0.03 Gusb NM_017015 -0.22 1.06E-09 Gyltl1b NM_199107 0.1 0.000000658 H2afx ENSRNOT00000059715 0.11 0.00686 H2afz NM_022674 -0.4 0 Habp4 NM_001079940 0.17 0.00000609 Hacl1 NM_053493 0.04 0.02 Hbb NM_033234 0.07 0.02 Hbegf NM_012945 -0.22 0.00000576 Hbs1l NM_001011934 -0.07 0.000373 Hcfc2 NM_001008357 -0.09 0.000618 Hdac3 NM_053448 -0.16 6.32E-10 Hddc3 ENSRNOT00000016445 0.06 0.00208 Hdhd2 BE101267 -0.14 0.00000095 Heatr5b ENSRNOT00000035905 -0.06 0.01 Hel308 BC086609 0.08 0.01 Hemgn ENSRNOT00000042649 0.12 0.03 Hiatl1 XM_001060279 -0.09 0.000277 Hibadh NM_022243 -0.29 3.01E-27 Hibch NM_001013112 -0.05 0.01 Higd1a NM_080902 0.13 0.03 Hip1r ENSRNOT00000001461 -0.15 0.02 Hist1h2ao_predicted ENSRNOT00000045512 0.05 0.05 Hist2h4_predicted ENSRNOT00000040210 0.09 0.02 Hk3 NM_022179 0.05 0.02 Hmga1 X62875 0.11 0.03 Hmga2 NM_032070 0.05 0.01 Hmgb2l1 ENSRNOT00000018692 -0.16 0.01 Hmgcs1 NM_017268 -0.09 0.01 Hmox2 J05405 0.03 0.04 Diabetes Page 100 of 288

Hn1 CK603822 -0.22 6.35E-17 Hn1l NM_001013182 0.05 0.00499 Hnrnpr NM_175603 -0.08 0.000000013 Hnrnpu ENSRNOT00000046781 -0.18 1.27E-08 Hnrpa3 NM_198132 0.06 0.0000031 Hnrpf NM_001037287 0.03 0.04 Hnrph1 NM_080896 -0.06 0.00203 Hnrpm NM_053876 -0.12 3.26E-14 Hnt NM_017354 0.07 0.02 Homez NM_152849 -0.14 0.00509 Hoxa10 ENSRNOT00000036394 0.11 0.000096 Hs1bp3 703884374J1 0.11 0.01 Hsbp1 NM_173119 -0.19 1.74E-20 Hsdl2 NM_001025697 -0.17 1.05E-08 Htatip NM_001005872 -0.1 0.000599 Htr5b ENSRNOT00000003441 0.07 0.02 Id2 ENSRNOT00000009491 -0.17 0.00273 Idh2 NM_001014161 0.04 0.05 Idh3a 703915184J1 0.06 0.02 Idi1 NM_053539 -0.24 1.2E-37 Ifitm1 ENSRNOT00000005645 -0.09 0.04 Ift122 ENSRNOT00000014733 -0.09 0.000463 Igfbp5 ENSRNOT00000023530 0.1 0.000266 Ighg NM_001013945 0.15 0.03 Il18 DQ230327 0.11 0.05 Il1rap BC097339 0.11 0.05 Il6st NM_001008725 -0.15 0.000262 Il7 NM_013110 0.07 0.000275 Il8ra NM_019310 0.09 0.02 Imp3 ENSRNOT00000023456 -0.39 1.1E-31 Imp4 NM_001009700 0.05 0.04 Impa1 NM_032057 0.05 0.00926 Impad1 704287440J1 -0.11 0.02 Ing4 ENSRNOT00000024116 -0.2 6.73E-15 Inpp5a XM_001058238 0.12 0.000729 Inpp5f DV718624 -0.06 0.01 Ints9 ENSRNOT00000018071 0.06 0.00612 Ipmk NM_134417 -0.11 0.00141 Ipo11 BC092638 0.07 0.00565 Ipo7 ENSRNOT00000014002 -0.11 0.00000907 Iqgap1 ENSRNOT00000018021 -0.1 0.01 Irak2 NM_001025422 0.12 0.02 Isg20 NM_001008510 -0.08 0.05 Isl1 NM_017339 -0.11 0.00158 Isoc1 NM_001014242 -0.29 3.86E-15 Isy1 NM_001014188 -0.04 0.02 Itch NM_001005887 -0.14 0.02 Page 101 of 288 Diabetes

Itfg1 NM_133557 0.04 0.01 Itga11 g11383337 0.09 0.04 Itga6 ENSRNOT00000045394 0.15 0.00248 Ivns1abp ENSRNOT00000059863 0.03 0.03 Izumo1 NM_001017514 0.06 0.04 Jagn1 NM_001044272 -0.04 0.000336 Jarid1b EV778094 -0.09 0.02 Josd1 NM_001025009 0.04 0.02 Jph1 ENSRNOT00000008153 -0.09 0.02 Katna1 NM_001004217 0.06 0.02 Kbtbd4 ENSRNOT00000012876 0.05 0.00417 Kcna4 NM_012971 0.17 0.0000514 Kcnb1 NM_013186 0.07 0.000262 Kcnc2 NM_139217 0.1 0.01 Kcnh1 NM_031742 0.09 0.00689 Kcnj9 g11388871 0.12 0.000182 Kcnmb2 NM_176861 -0.2 0.02 Kctd15 ENSRNOT00000028698 -0.07 0.03 Kctd19 XM_001075666 -0.06 0.05 Kctd2 ENSRNOT00000032608 -0.08 0.000136 Kdsr ENSRNOT00000003728 -0.06 0.00237 Ke2 NM_212506 0.04 0.00975 Khdrbs2 NM_133318 -0.13 0.00122 Kif19a XM_221082 0.07 0.04 Kif1a g8497651 -0.09 0.01 Kif20a ENSRNOT00000033784 -0.12 0.00133 Kif21a ENSRNOT00000038946 -0.23 1.49E-38 Kif23 ENSRNOT00000037028 -0.13 0.000315 Kirrel BG673065 -0.12 0.02 Kit NM_022264 -0.29 3.14E-08 Kitl AB105879 -0.28 0.00000736 Klf10 NM_031135 -0.09 0.03 Klf2 NM_001007684 -0.08 0.04 Klf7 g3704598 -0.13 0.00464 Klf9 AI113128 -0.08 0.000109 Klhdc2 NM_001034133 0.04 0.03 Klhdc8b NM_001007685 -0.09 0.02 Klhl13 ENSRNOT00000018788 0.06 0.00207 Klhl24 NM_181473 -0.22 7.58E-12 Klhl31 702233236F6 0.12 0.0011 Klhl8 AW534564 -0.08 0.00464 Kpna3 BC111706 0.05 0.00146 Kras NM_031515 -0.06 0.00539 Krt40 NM_001008821 -0.08 0.01 Ktelc1 ENSRNOT00000051428 0.1 1.81E-09 Kti12 NM_001044288 0.04 0.00451 L3mbtl3 704196115H1 -0.05 0.03 Diabetes Page 102 of 288

Lamc1 g11671089 0.1 0.00027 Larp6 ENSRNOT00000017147 0.08 0.03 Las1l ENSRNOT00000016042 0.05 0.04 Lass2 CF110567 -0.28 6.3E-22 Lbx1 NM_001047108 0.06 0.03 Lcmt1 NM_199405 0.05 0.03 Ldb2 DY315258 -0.11 0.03 Ldhal6b NM_183334 0.06 0.00985 Ldhb NM_012595 0.35 3.28E-10 Lefty2 NM_001007556 0.09 0.02 Leprotl1 NM_001013188 -0.21 1.01E-15 Lgi2 CB770356 -0.09 0.04 Lgr4 NM_173328 -0.06 0.04 Limd2 NM_001025715 -0.32 0 Lin7a NM_053514 0.15 0.00013 Lipn ENSRNOT00000026242 0.06 0.04 Lmnb1 NM_053905 -0.1 0.00483 Lmo7 NM_001001515 -0.17 0.01 LOC679931 XM_001056792 0.07 0.04 LOC680445 XM_001074986 -0.09 0.00159 LOC680549 ENSRNOT00000048875 0.07 0.03 LOC681086 XM_001060262 0.05 0.000333 LOC681367 XM_001061427 0.04 0.02 LOC685284 ENSRNOT00000013615 0.07 0.00147 LOC685667 ENSRNOT00000041124 -0.09 0.00954 LOC685888 ENSRNOT00000035033 0.05 0.03 LOC689176 ENSRNOT00000009759 -0.33 0.0000238 LOC689226 CN541495 -0.21 0.00000161 LOC689296 ENSRNOT00000029411 -0.16 0.000000452 LOC689572 ENSRNOT00000047630 -0.05 0.01 LOC689574 XM_001068230 0.06 0.01 LOC689582 NM_001079712 0.08 0.04 LOC689775 XM_001071952 0.06 0.04 LOC689986 XM_001061679 -0.11 0.02 LOC690208 ENSRNOT00000007369 0.07 0.0077 LOC690303 ENSRNOT00000013725 0.05 0.04 LOC690470 ENSRNOT00000012214 -0.16 0.00000413 LOC691862 XM_001080848 0.14 0.00109 Lpcat1 ENSRNOT00000024111 0.06 0.00427 Lppr4 NM_001001508 0.07 0.000624 Lrp11 ENSRNOT00000062020 -0.11 0.00000168 Lrpap1 ENSRNOT00000012665 0.1 0.00126 Lrrc28 ENSRNOT00000033858 0.11 0.03 Lrrc40 NM_001034926 0.04 0.00787 Lrrc47 ENSRNOT00000034284 -0.08 0.00898 Lrrc49 ENSRNOT00000016456 -0.12 0.000279 Lrrc52 NM_001077434 0.08 0.02 Page 103 of 288 Diabetes

Lrrc57 NM_001012354 -0.06 0.04 Lrrc59 NM_001008280 0.07 0.000705 Lrrfip1 NM_001014269 -0.35 5.26E-13 Lrrn3 NM_030856 0.09 0.05 Lsm1 ENSRNOT00000020721 0.08 0.01 Lsm3 ENSRNOT00000011557 0.06 0.05 Lsm4 ENSRNOT00000026567 -0.27 0 Lsm8 ENSRNOT00000011456 -0.33 3.41E-37 Ltbp1 NM_021587 -0.09 0.04 Luc7l2 ENSRNOT00000008557 -0.13 1.08E-26 Lyk5 NM_182820 0.05 0.00561 Lypla2 NM_031342 0.05 0.01 Lypla3 NM_001004277 0.12 0.0003 Lyplal1 ENSRNOT00000032865 0.04 0.04 Lysmd1 NM_001024302 0.09 0.00148 Lysmd2 ENSRNOT00000014301 -0.05 0.03 Mad2l1 AF257321 -0.06 0.0023 Maea NM_001008319 0.05 0.00217 Mafg NM_022386 -0.11 0.02 Mafk NM_145673 -0.09 0.00636 Mageh1 NM_001013250 -0.1 0.05 Maml1 ENSRNOT00000004361 0.09 0.00107 Man2a1 ENSRNOT00000020767 -0.12 0.00765 Map1lc3b NM_022867 0.06 0.00837 Map2k1 NM_031643 0.06 0.03 Map2k4 702794086T2 0.05 0.03 Map3k3 ENSRNOT00000011406 -0.17 0.000000269 Map4k3 XM_001055154 0.05 0.02 Mapk1 BM422632 -0.37 0.01 Mapk12 NM_021746 0.06 0.01 Mapk8 BI297991 -0.16 7.37E-11 Mapk9 BI282175 -0.04 0.03 Mapkapk2 NM_178102 -0.35 5.52E-11 Mapt NM_017212 -0.27 2.76E-21 Mark3 NM_130749 -0.05 0.02 Mat1a NM_012860 0.08 0.000224 Matk NM_021859 -0.1 0.00301 Matr3 NM_019149 -0.07 0.000248 Max BC099778 0.08 0.00000384 Mbl1 NM_012599 0.07 0.03 Mcart1 NM_001024785 -0.1 0.0000271 Mccc1 NM_001009653 0.06 0.03 Mcfd2 NM_139253 0.09 0.00341 Mcm2 XM_001072364 -0.12 0.000000011 Mcm5 ENSRNOT00000019677 -0.1 0.000375 Mcts1 NM_001044237 0.04 0.05 Mdn1 AI138044 0.07 0.03 Diabetes Page 104 of 288

Med30 ENSRNOT00000006480 0.06 0.0052 Med6 ENSRNOT00000009483 0.07 0.00458 Med8 ENSRNOT00000038161 0.08 0.04 Melk ENSRNOT00000018650 -0.29 2.33E-42 Mertk NM_022943 -0.06 0.04 Mesdc2 NM_001008345 -0.05 0.00233 Mettl10 ENSRNOT00000023121 0.04 0.04 Mettl3 NM_001024794 -0.07 0.03 Mfap3 NM_001007609 0.07 0.0000715 Mgat2 NM_053604 0.08 0.00523 Mgea5 CK226272 -0.16 0.00101 Mical2 BF288546 0.09 0.05 Mid1ip1 NM_206950 -0.05 0.0033 Mier1 ENSRNOT00000009438 -0.11 0.00888 Mier3 ENSRNOT00000017571 0.07 0.000417 Mif4gd NM_001014122 -0.13 2.62E-10 Mknk2 NM_001011985 -0.2 0.000341 Mlh3 g3725668 -0.14 0.02 Mnt ENSRNOT00000003933 -0.13 0.00953 Moap1 NM_001013101 0.06 0.000232 Mobkl1b NM_001033891 -0.1 0.0000594 Mobkl2b ENSRNOT00000012519 0.06 0.01 Mobkl3 NM_133528 -0.07 0.00512 Mogat1 ENSRNOT00000019724 0.07 0.01 Morc2a g3638011 0.06 0.05 Mras NM_012981 0.16 0.00117 Mrc2 BQ208907 0.08 0.03 Mrpl12 NM_001029900 0.08 3.91E-10 Mrpl15 ENSRNOT00000011619 0.04 0.00136 Mrpl18 ENSRNOT00000020064 0.09 0.00000791 Mrpl19 NM_001029898 0.05 0.03 Mrpl21 ENSRNOT00000018848 0.04 0.00428 Mrpl53 ENSRNOT00000011427 0.04 0.01 mrpl9 NM_001007696 0.04 0.05 Mrps11 ENSRNOT00000025008 -0.3 1.82E-44 Mrps12 ENSRNOT00000027029 0.05 0.03 Mrps15 NM_001007653 0.05 0.04 Mrps2 g4132969 0.06 0.02 Mrps25 NM_001025408 0.09 0.0000226 Mrps27 ENSRNOT00000023286 -0.12 0.000132 Mrto4 ENSRNOT00000024326 0.07 0.01 Msi2 BF388985 -0.43 3.43E-43 Msl2l1 g8500991 -0.08 0.03 Msl31 NM_001014111 -0.14 0.00000324 Msrb2 NM_001031660 -0.07 0.00000666 Mt3 NM_053968 0.04 0.04 Mta2 ENSRNOT00000027141 0.07 0.03 Page 105 of 288 Diabetes

Mtap NM_001047867 0.06 0.03 Mtap6 AI146127 0.07 0.03 Mtdh AI230755 -0.09 0.02 Mtf2 BC093403 -0.13 0.00207 Mthfs NM_001009349 -0.44 6.62E-27 Mtm1 NM_001013047 0.07 0.00213 Mtmr12 NM_001012077 -0.13 0.02 Mto1 XM_217208 -0.17 0.00000553 Mtp18 NM_001006960 0.12 0.02 Mtpn ENSRNOT00000015808 0.06 0.00935 Mtus1 NM_178093 -0.05 0.02 Mtx2 NM_001008286 0.07 0.000524 Mx2 NM_134350 -0.08 0.04 Mycbp2 ENSRNOT00000014583 -0.24 9.93E-14 Myeov2 CB313601 0.06 0.00383 Myh9 BP492000 0.18 0.0000195 Myo1f XM_234942 0.07 0.02 Myo9a NM_134335 -0.12 0.000261 Nab1 CK601822 0.07 0.01 Naca ENSRNOT00000003550 -0.04 0.00479 Nacad ENSRNOT00000044768 0.07 0.01 Naip2 ENSRNOT00000024501 0.1 0.02 Nalcn AY555273 -0.08 0.02 Nanp NM_001009409 0.07 0.03 Nap1l1 703942719J1 -0.2 2.05E-08 Nap1l2 NM_001024789 -0.11 0.000242 Narg1 g3728042 0.06 0.02 Nat2 NM_053854 0.07 0.01 Nat5 XM_001055084 0.06 0.00156 Nbr1 NM_001024765 -0.07 0.0071 Ncf4 ENSRNOT00000009544 0.07 0.02 Ncr3 NM_181822 0.11 0.04 Ndel1 NM_133320 0.07 0.00862 Ndfip1 NM_001013059 -0.03 0.000856 Ndfip2 BG671972 0.12 0.00086 Ndrg1 NM_001011991 -0.32 9.24E-21 Ndrg4 NM_031967 -0.25 0.000399 Ndst2 ENSRNOT00000035100 0.08 0.01 Ndufb7 ENSRNOT00000035890 0.04 0.00838 Ndufs3 ENSRNOT00000012425 0.05 0.01 Ndufv1 NM_001006972 -0.25 0 Ndufv2 NM_031064 0.03 0.04 Neb ENSRNOT00000059463 0.11 0.01 Necap1 NM_001029919 -0.22 1.06E-17 Nedd4l 702548904R6 0.11 0.04 Nefm NM_017029 0.12 0.02 Nek8 ENSRNOT00000017264 -0.09 0.05 Diabetes Page 106 of 288

Nfasc NM_053909 0.06 0.03 Nfatc2ip NM_001007692 -0.19 0.00467 Nfe2l1 BF560692 0.07 0.03 Nfib NM_031566 -0.18 0.000607 Nfyb NM_031553 0.07 0.000267 Nfyc NM_012866 -0.06 0.00549 Ngfr NM_012610 -0.07 0.01 Ngly1 NM_001014136 -0.22 1.67E-17 Nid2 CA510191 0.08 0.01 Nin ENSRNOT00000052408 -0.08 0.01 Nip7 NM_138847 0.04 0.05 Nipa2 ENSRNOT00000018028 0.06 0.04 Nkap CV108587 -0.13 0.04 Nkiras2 ENSRNOT00000024543 -0.24 3.52E-16 Nkx2-2 ENSRNOT00000017364 0.07 0.0043 Nle1 XM_001081007 0.07 0.02 Nln NM_053970 -0.1 0.0000845 Nme6 ENSRNOT00000028125 0.07 0.02 Noc3l ENSRNOT00000019056 -0.07 0.01 Nol3 NM_053516 -0.07 0.01 Nol4 700643635F6 -0.07 0.0000429 Nol5 AF069782 -0.11 0.0002 Nol7 CB556727 0.04 0.02 Nola1 NM_001024306 0.05 0.04 Nolc1 M94288 0.07 0.00796 Nova1 ENSRNOT00000044527 -0.21 2.24E-09 Nox1 NM_053683 -0.16 0.00439 Nphp1 ENSRNOT00000021328 0.06 0.0000532 Nr2f1 NM_031130 0.09 0.02 Nrep AY724475 -0.35 3.25E-14 Nrg1 AY973241 0.09 0.02 Nsun2 ENSRNOT00000023641 0.04 0.02 Nt5c3 ENSRNOT00000007995 0.07 0.00303 Nucks1 NM_022799 0.06 0.03 Nudt22 NM_199090 0.05 0.04 Nudt4 NM_053598 -0.22 9.81E-12 Nufip1 NM_001007758 0.05 0.01 Nup210 NM_053322 0.05 0.03 Nup35 NM_001004229 0.05 0.01 Nup54 NM_017361 -0.14 1.65E-09 Nupl1 ENSRNOT00000017204 -0.1 0.0000714 Nvl ENSRNOT00000004927 0.05 0.03 Oas2 NM_001009715 -0.09 0.02 Obp1f NM_138903 -0.11 0.04 Obscn ENSRNOT00000058419 0.07 0.04 Odf2 NM_017213 0.06 0.00181 Ogfod1 DN934519 0.05 0.01 Page 107 of 288 Diabetes

Ogfr NM_053340 0.05 0.02 Ogfrl1 NM_001025708 0.09 0.000549 Olfm1 NM_053573 -0.19 0.000000116 Olr1418 NM_001000008 0.04 0.03 Olr1607 NM_001000534 0.07 0.01 Olr869 NM_001000413 0.09 0.02 Oplah BF283094 0.11 0.00189 Oprs1 NM_030996 0.06 0.00893 Orc5l NM_001014186 -0.13 0.000595 Orc6l NM_001033690 0.06 0.00575 Ormdl2 ENSRNOT00000044292 0.07 0.00155 Ostm1 NM_001029925 0.09 0.00219 Otud7b DV722502 -0.1 0.0037 Oxnad1 ENSRNOT00000026751 0.05 0.00476 P2rx3 NM_031075 -0.1 0.04 P2rx4 NM_031594 0.05 0.04 P4ha1 NM_172062 -0.18 0.00000682 P4ha2 ENSRNOT00000042144 -0.09 0.03 Pabpc4 ENSRNOT00000056592 0.06 0.04 Pabpnl1 ENSRNOT00000045052 -0.09 0.00000817 Pacsin2 NM_130740 -0.1 0.01 Pafah1b1 NM_031763 -0.11 0.00602 Pah NM_012619 -0.04 0.03 Paip2 NM_001014148 -0.16 1.84E-13 Pak6 ENSRNOT00000010471 0.07 0.04 Papd4 NM_001008372 -0.09 0.0000415 Papd5 ENSRNOT00000033307 -0.21 2.94E-12 Papola BC083612 -0.28 1.16E-25 Paqr3 NM_001012033 -0.33 5.01E-11 Parp1 NM_013063 0.07 0.0000784 Pars2 NM_001014064 0.07 0.02 Pawr NM_033485 0.1 0.000373 Pcbp3 NM_001011945 0.07 0.00045 Pcca M22631 0.07 0.02 Pcgf2 ENSRNOT00000017241 -0.06 0.00492 Pcgf3 CA506321 -0.18 0.00691 Pcgf6 NM_001013154 -0.29 2.37E-42 Pclo NM_020098 -0.13 0.04 Pcm1 U95920 -0.04 0.02 Pctp NM_017225 0.15 7.68E-10 Pdcl3 BI289420 -0.22 2.66E-32 Pde10a AB027156 0.04 0.03 Pde1c AF329856 0.11 0.02 Pde3b 703206608J1 -0.2 6.87E-23 Pde7a ENSRNOT00000043859 -0.17 0.000000375 Pdhb NM_001007620 -0.06 0.02 Pdhx NM_001044242 0.09 0.00248 Diabetes Page 108 of 288

Pdlim1 NM_017365 0.05 0.000526 Pdp2 NM_145091 -0.18 0.00541 Pea15a BG673078 -0.06 0.00879 Peli2 CB776569 -0.14 0.000157 Pex1 BI296060 -0.08 0.000515 Pex14 NM_172063 -0.05 0.05 Pex7 NM_001034147 -0.07 0.01 Pfas ENSRNOT00000007087 -0.06 0.03 Pfkfb2 NM_080477 -0.18 0.000124 Pfn2 NM_030873 -0.18 3.43E-22 Pgm1 NM_017033 0.05 0.02 Pgm2l1 ENSRNOT00000022963 -0.13 0.0000629 Pgrmc2 704298571J1 0.05 0.03 Phb NM_031851 0.07 0.0000221 Phb2 NM_001013035 0.03 0.03 Phf10 NM_001024747 -0.12 0.000000211 Phf12 ENSRNOT00000056234 -0.11 0.05 Phf13 ENSRNOT00000012407 -0.09 0.01 Phf20l1 ENSRNOT00000007564 -0.22 0.00000065 Phkg1 NM_031573 -0.07 0.00766 Phlda2 ENSRNOT00000027972 0.13 0.00179 Phlda3 NM_001012206 -0.25 0.00835 Phyhipl NM_001012076 -0.08 0.01 Pi4k2b NM_001005883 -0.26 0.0000134 Pias2 NM_053337 -0.12 0.00000151 Pigo ENSRNOT00000013213 0.05 0.00546 Pigq NM_001007607 -0.1 0.0000173 Pigs NM_001006602 0.07 0.000455 Pigw NM_194461 0.08 0.000655 Pigy NM_001024370 -0.1 0.0000194 Pim1 AI008309 -0.24 0.02 Pitpna NM_017231 0.05 0.000126 Pja2 NM_138896 -0.04 0.03 Pkhd1 XM_236979 0.1 0.0000138 Pkp2 ENSRNOT00000002498 0.1 0.05 Pla2g4c ENSRNOT00000033633 0.07 0.00522 Pla2g6 NM_001005560 -0.18 0.0000181 Plac9 ENSRNOT00000014964 -0.11 0.01 Plagl1 NM_012760 -0.18 0.00586 Plcb1 L14323 -0.13 0.00222 Plcl1 AI072447 -0.19 0.0000272 Pldn NM_001025714 -0.09 0.0000103 Plekha5 AF468695 -0.06 0.03 Plekhb1 NM_172033 -0.12 0.000121 Plp2 NM_207601 0.04 0.04 Plscr4 CN542354 0.11 0.02 Plxdc2 AI029495 0.07 0.03 Page 109 of 288 Diabetes

Pms1 NM_001009535 0.04 0.0044 Pnldc1 NM_001025724 0.06 0.05 Pnmal1 ENSRNOT00000029825 0.12 0.04 Pnn ENSRNOT00000005439 -0.11 0.000135 Pnpla7 ENSRNOT00000011633 -0.14 0.000028 Pnpla8 704297787J1 -0.14 0.00123 Pnrc1 NM_173322 -0.22 0.00000227 Polb ENSRNOT00000026039 0.12 0.00018 Pold3 NM_001024750 -0.12 4.68E-08 Pole3 BC081988 -0.82 1.56E-42 Pole4 XM_001071977 0.06 0.000826 Polr1e ENSRNOT00000029704 0.09 0.000768 Polr2c NM_001012473 0.04 0.02 Polr2g NM_053948 -0.1 6.56E-08 Polr2j ENSRNOT00000001941 -0.26 1.65E-10 Polr3b XM_343188 -0.06 0.0099 Polr3d NM_001031653 0.07 0.000239 Polr3h ENSRNOT00000005943 0.06 0.01 Pols ENSRNOT00000023712 -0.1 0.00692 Pom121 NM_053622 -0.14 0.00663 Ppargc1b NM_176075 0.11 0.00472 Ppfia1 ENSRNOT00000039677 0.05 0.02 Ppfibp1 ENSRNOT00000044147 -0.15 0.0000811 Pphln1 AY724510 0.09 0.00572 Ppif NM_172243 0.16 4.26E-17 Ppig NM_031793 -0.12 0.00358 Ppil3 NM_175707 0.06 0.01 Ppm1d 704156493J1 0.05 0.04 Ppm1f NM_175755 0.23 0.04 Ppm1k DY471972 -0.07 0.04 Ppp1r14b NM_172045 -0.38 2.39E-41 Ppp1r14c NM_133425 0.07 0.0049 Ppp1r3b NM_138912 -0.14 0.00523 Ppp1r3d 700371222F6 -0.2 2.4E-11 Ppp2r1a NM_057140 -0.13 0.00000772 Ppp2r1b NM_001025418 0.05 0.01 Ppp2r2b D14421 0.09 0.04 Ppp2r2d NM_144746 0.03 0.02 Ppp2r5a ENSRNOT00000000078 -0.09 0.0000197 Ppp2r5c XM_001077680 -0.14 5.14E-09 Ppp3r1 NM_017309 0.09 0.000162 Ppp4r1 NM_080907 -0.15 0.00101 Ppp4r2 ENSRNOT00000029115 -0.07 0.03 Ppp6c NM_133589 0.05 0.02 Ppt1 ENSRNOT00000017998 -0.17 0.000000221 Ppt2 NM_019367 0.11 0.00159 Pqlc1 NM_001013189 0.1 0.00635 Diabetes Page 110 of 288

Pqlc2 ENSRNOT00000023896 0.07 0.000272 Pqlc3 NM_001034952 0.06 0.0000715 Prkaa1 BM392332 -0.18 9.81E-08 Prkaa2 NM_023991 -0.42 0.0000244 Prkab1 NM_031976 -0.05 0.02 Prkaca ENSRNOT00000007303 -0.21 0.00127 Prkag1 NM_013010 -0.05 0.000142 Prkar1a CF110967 -0.15 1.24E-09 Prkar2a g18186932 0.11 0.0000111 Prkce CR457587 -0.11 0.05 Prkd3 ENSRNOT00000007492 -0.19 0.00297 Prlr NM_001034111 0.08 0.04 Prmt2 NM_001025144 -0.07 0.000684 Prmt5 XM_001054376 0.05 0.02 Prnpip1 BC099220 0.05 0.04 Prosc ENSRNOT00000018369 0.06 0.000752 Prpf31 ENSRNOT00000018683 0.07 0.04 Prps1 NM_017243 -0.18 1.47E-15 Prr16 ENSRNOT00000026724 0.12 0.01 Prss22 ENSRNOT00000060888 -0.08 0.02 Prtfdc1 AI104491 -0.29 0.00000025 Prx BP470226 0.09 0.00625 Psat1 NM_198738 -0.13 0.00000414 Pscd1 NM_053910 -0.18 0.03 Psip1 BC093606 -0.11 0.00305 Pskh1 ENSRNOT00000026163 0.06 0.03 Psma1 NM_017278 -0.07 0.00237 Psma3 NM_017280 0.04 0.05 Psma4 NM_017281 0.05 0.01 Psmb4 NM_031629 -0.06 0.0000933 Psmb8 NM_080767 0.08 0.02 Psmd1 BC087654 -0.11 0.00978 Psmd12 NM_001005875 -0.18 2.82E-22 Psme3 NM_001011894 0.08 0.00183 Ptbp2 NM_001005555 -0.14 0.000000126 Ptdss2 ENSRNOT00000021925 0.07 0.00621 Ptges2 ENSRNOT00000019184 -0.09 0.00189 Ptma NM_021740 0.05 0.03 Ptpmt1 ENSRNOT00000013584 0.04 0.02 Ptpn3 BC092605 0.07 0.03 Ptprh ENSRNOT00000024492 0.06 0.03 Ptpro NM_017336 0.13 0.01 Ptprr NM_053594 -0.08 0.02 Pum2 XM_001068003 -0.07 0.03 Pura XM_226016 -0.12 0.04 PVR NM_017076 0.12 0.0000851 Pxmp4 NM_172223 0.1 0.000328 Page 111 of 288 Diabetes

Pycr2 NM_001012208 0.06 0.02 Qdpr NM_022390 0.04 0.03 Qki DN933927 0.1 0.00342 Qrsl1 BF550674 -0.09 0.00521 R3hcc1_predicted ENSRNOT00000022706 0.06 0.00147 R3hdm1 ENSRNOT00000005372 0.05 0.00352 Rab11a NM_031152 -0.17 1.65E-09 Rab19 NM_001024326 0.06 0.01 Rab28 NM_053978 0.04 0.02 Rab2b NM_001037645 0.06 0.04 Rab33b DV725908 -0.31 2.42E-14 Rab36 ENSRNOT00000001772 -0.06 0.02 Rab4b NM_017355 0.04 0.04 Rabgap1 ENSRNOT00000013378 -0.06 0.04 Rabl2a NM_001013221 -0.32 2.38E-08 Rad1 ENSRNOT00000024557 -0.07 0.04 Rad51c ENSRNOT00000008846 -0.1 0.04 Ralb NM_053821 0.06 0.00239 Ralgps2 CR468742 0.04 0.01 g18186257 0.09 0.04 Rangrf ENSRNOT00000006883 0.05 0.04 Rap1a NM_001005765 -0.21 6.8E-14 Rap1b BC081731 -0.24 0.000000605 Rap2a BQ208481 0.12 0.00000152 Rapgef4 ENSRNOT00000048797 -0.17 1.73E-08 Rapgefl1 BC091361 0.07 0.04 Rars2 ENSRNOT00000011688 0.05 0.02 Rasa1 CF249348 -0.28 5.71E-22 Rasgrp2 CN541896 -0.12 0.02 Rassf3 AA893698 -0.17 0.000000176 Raver2 XM_001061591 0.1 0.000169 Rb1cc1 ENSRNOT00000010014 -0.15 0.0000451 Rbbp5 XM_001060117 0.04 0.02 Rbl1 ENSRNOT00000009528 -0.1 0.00313 Rbm17 NM_001013058 0.04 0.04 Rbm18 XM_001080367 -0.18 8.46E-17 Rbm24 g4132748 -0.08 0.0000325 Rbm41 702966479F6 -0.15 0.00172 Rc3h2 ENSRNOT00000012354 -0.1 0.02 Rcbtb1 ENSRNOT00000037800 0.06 0.02 rCG_22919 DV716116 -0.41 7.01E-45 rCG_28701 ENSRNOT00000019647 0.05 0.00681 Rchy1 NM_001007618 -0.05 0.01 Rcn2 NM_017132 0.06 0.00417 Rdh10 NM_181478 -0.1 0.04 Rdx BF557204 -0.2 0.00000101 Reck ENSRNOT00000020755 0.25 1.25E-08 Diabetes Page 112 of 288

Rell1 ENSRNOT00000002984 -0.17 1.47E-09 Retn NM_144741 0.07 0.00516 Rfc2 NM_053786 0.03 0.03 Rfpl4 ENSRNOT00000021077 0.09 0.00875 Rfx5 BC089912 -0.09 0.01 Rfxank NM_001013136 0.03 0.02 Rfxdc2 ENSRNOT00000030629 -0.08 0.00703 RGD1303003 NM_001004225 0.04 0.03 RGD1304607 ENSRNOT00000028079 0.07 0.0000157 RGD1304719 NM_001037769 -0.04 0.02 RGD1304773 NM_001025126 0.06 0.04 RGD1304840 ENSRNOT00000037211 -0.08 0.02 RGD1305045 ENSRNOT00000008364 0.03 0.04 RGD1305138 XM_235689 0.08 0.0031 RGD1305157 ENSRNOT00000014323 0.07 0.03 RGD1305235 NM_001017447 -0.14 0.0000159 RGD1305314 NM_001030038 -0.12 0.00737 RGD1305350 ENSRNOT00000010558 -0.09 0.000996 RGD1305592 NM_001013901 -0.07 0.0000158 RGD1305645 XM_343562 0.06 0.03 RGD1305727 NM_001047095 0.06 0.02 RGD1306001 ENSRNOT00000055909 0.03 0.04 RGD1306151 ENSRNOT00000011241 -0.16 0.0000844 RGD1306215 ENSRNOT00000020806 -0.09 0.00172 RGD1306437 NM_001009635 0.05 0.00088 RGD1306502 DV722552 -0.08 0.000456 RGD1306508 CK482189 -0.05 0.00412 RGD1306568 NM_001013963 -0.09 0.00073 RGD1306583 NM_001013908 0.04 0.00426 RGD1306595 NM_001025626 -0.06 0.00525 RGD1306730 NM_001039608 0.04 0.01 RGD1306739 ENSRNOT00000000785 0.07 0.04 RGD1306809 NM_001044252 -0.11 0.00027 RGD1306820 ENSRNOT00000023827 -0.08 0.02 RGD1306839 ENSRNOT00000021544 0.08 0.0039 RGD1306924 ENSRNOT00000018460 0.08 0.000213 RGD1306936 ENSRNOT00000011970 0.04 0.03 RGD1307067 ENSRNOT00000015869 0.07 0.00895 RGD1307179 ENSRNOT00000005828 0.05 0.000626 RGD1307234 XM_001056555 -0.12 0.000504 RGD1307279 NM_001008343 0.05 0.03 RGD1307325 NM_001014001 -0.39 9.72E-14 RGD1307392 ENSRNOT00000013560 0.06 0.04 RGD1307465 NM_001009655 -0.12 0.00000158 RGD1307509 NM_001014036 0.11 0.02 RGD1307526 DY314397 -0.33 1.59E-08 RGD1307554 CO404930 -0.08 0.00652 Page 113 of 288 Diabetes

RGD1307648 NM_001013905 0.05 0.02 RGD1307682 NM_001024760 -0.08 0.00781 RGD1307696 DW395452 -0.19 0.0000178 RGD1307752 NM_001013922 0.05 0.00396 RGD1307799 NM_001017454 0.03 0.03 RGD1307983 ENSRNOT00000022987 -0.13 4.12E-08 RGD1308143 BC083847 -0.11 0.01 RGD1308179 ENSRNOT00000005504 0.11 0.02 RGD1308221 ENSRNOT00000004093 -0.11 0.0000959 RGD1308290 NM_001047902 -0.09 0.00645 RGD1308432 CA509333 0.08 0.000153 RGD1308470 NM_001014198 0.08 0.000303 RGD1308517 NM_001037181 -0.07 0.00647 RGD1308544 XM_001063171 0.06 0.04 RGD1308584 XM_001066199 0.03 0.02 RGD1308600 NM_001014178 0.07 0.02 RGD1308601 CB775949 -0.23 1.19E-38 RGD1308635 ENSRNOT00000025386 0.06 0.0000131 RGD1308706 ENSRNOT00000023169 -0.25 7.05E-29 RGD1308847 NM_001100945 0.1 0.00012 RGD1308874 NM_001034003 -0.03 0.04 RGD1308915 NM_001014226 0.14 0.00000555 RGD1308917 ENSRNOT00000006321 0.07 0.00924 RGD1308923 XM_001076736 -0.06 0.04 RGD1309020 ENSRNOT00000018508 -0.14 0.000000339 RGD1309104 BE111666 -0.24 7.98E-11 RGD1309108 ENSRNOT00000010743 0.12 0.00547 RGD1309148 ENSRNOT00000031852 0.05 0.02 RGD1309216 NM_001008371 0.07 0.000762 RGD1309228 g14949127 0.07 0.03 RGD1309308 XM_232850 0.08 0.02 RGD1309360 ENSRNOT00000018058 -0.1 0.00622 RGD1309501 g2862952 0.08 0.00954 RGD1309676 NM_001014140 -0.09 0.00112 RGD1309759 ENSRNOT00000020810 0.07 0.03 RGD1309779 ENSRNOT00000011017 -0.16 2.62E-12 RGD1309784 NM_001014212 -0.15 0.00000834 RGD1309871 XM_001076952 -0.28 1.95E-15 RGD1309985 ENSRNOT00000022344 -0.06 0.00728 RGD1309995 BC091295 -0.15 0.000205 RGD1310159 CK843962 -0.09 0.01 RGD1310260 ENSRNOT00000010832 -0.07 0.04 RGD1310263 704197764H1 -0.23 0.000000567 RGD1310270 ENSRNOT00000038144 -0.07 0.00487 RGD1310351 XM_216499 0.07 0.02 RGD1310352 ENSRNOT00000008119 -0.14 6.05E-08 RGD1310358 BE101449 -0.14 6.52E-08 Diabetes Page 114 of 288

RGD1310427 ENSRNOT00000024450 -0.26 3.93E-19 RGD1310552 ENSRNOT00000052158 -0.2 0.01 RGD1310553 NM_001008517 -0.08 0.04 RGD1310571 AI599496 0.07 0.03 RGD1310606 NM_001024984 0.06 0.00423 RGD1310660 NM_001009316 0.11 0.0000111 RGD1310686 703920155J1 0.06 0.03 RGD1310784 ENSRNOT00000020637 0.07 0.000155 RGD1310794 NM_001024246 -0.06 0.02 RGD1310861 NM_001008290 -0.04 0.01 RGD1310868 ENSRNOT00000038088 -0.13 0.00242 RGD1310975 ENSRNOT00000017800 0.08 0.00112 RGD1311077 ENSRNOT00000010768 -0.1 0.00968 RGD1311186 ENSRNOT00000024976 0.05 0.01 RGD1311257 NM_001008307 0.06 0.01 RGD1311260 NM_001013967 0.08 0.000396 RGD1311378 ENSRNOT00000005901 0.07 0.05 RGD1311493_predicted ENSRNOT00000028407 0.08 0.04 RGD1311517 NM_001014072 0.05 0.03 RGD1311648 NM_001014075 0.06 0.04 RGD1311745 NM_001008329 0.06 0.01 RGD1311783 ENSRNOT00000027196 -0.14 0.00145 RGD1311815 NM_001034149 0.15 0.000000058 RGD1311863 NM_001024974 0.1 0.00334 RGD1311892 ENSRNOT00000035404 0.05 0.02 RGD1311939 ENSRNOT00000005664 -0.1 0.04 RGD1311946 NM_001025683 0.17 0.00181 RGD1311970 ENSRNOT00000034137 0.1 0.01 RGD1359108 NM_001007702 -0.07 0.00193 RGD1359127 NM_001007657 0.1 1.46E-08 RGD1359378 NM_001007658 -0.08 0.03 RGD1359713 NM_001005882 0.07 0.000723 RGD1559610 ENSRNOT00000009882 0.08 0.0000496 RGD1559690 ENSRNOT00000031974 -0.18 0.00000928 RGD1559896 ENSRNOT00000025512 -0.05 0.05 RGD1559923 ENSRNOT00000020074 -0.29 6.35E-18 RGD1559982 XM_219714 0.09 0.03 RGD1560065 ENSRNOT00000019964 0.09 0.0000488 RGD1560258 ENSRNOT00000001218 0.07 0.0000134 RGD1560277 XM_001066043 0.1 0.00906 RGD1560300 CK225315 0.12 0.02 RGD1560364 XM_343418 -0.05 0.03 RGD1560391_predicted NM_001039036 -0.09 0.03 RGD1560470 g11391537 -0.07 0.03 RGD1560620 704291381J1 -0.11 0.03 RGD1560812 XM_576015 -0.18 0.04 RGD1560888 XM_001061556 0.08 0.00304 Page 115 of 288 Diabetes

RGD1560909 ENSRNOT00000031352 0.06 0.02 RGD1560943 ENSRNOT00000046589 0.08 0.04 RGD1561057 XM_578135 -0.04 0.05 RGD1561067 XM_573923 -0.12 0.000644 RGD1561069 NM_001044259 0.07 0.01 RGD1561102 XM_001080032 0.08 0.01 RGD1561141 XM_230015 -0.06 0.000328 RGD1561302 CK597015 -0.14 0.00000613 RGD1561415 ENSRNOT00000024125 0.1 0.03 RGD1561474 ENSRNOT00000058589 -0.16 0.02 RGD1561605 BP465710 -0.15 0.03 RGD1561654 XM_001079552 -0.12 0.0000182 RGD1561817 g4239323 -0.05 0.00943 RGD1562020 XM_214370 -0.08 0.0000313 RGD1562052 XM_573539 -0.12 0.03 RGD1562218 NM_001034919 -0.26 2.04E-09 RGD1562272 ENSRNOT00000000260 -0.12 0.02 RGD1562351 XM_001062525 0.06 0.00659 RGD1562464 ENSRNOT00000011539 0.07 0.0059 RGD1562529 AA946404 -0.09 0.000263 RGD1562557 ENSRNOT00000051685 0.05 0.04 RGD1562665 XM_343264 0.08 0.03 RGD1562965 AA851969 -0.16 0.02 RGD1562997 XM_001073245 -0.2 0.0000385 RGD1563100 ENSRNOT00000006506 0.1 0.02 RGD1563106 ENSRNOT00000007447 -0.05 0.04 RGD1563109 BE108013 0.07 0.04 RGD1563170 ENSRNOT00000058701 0.08 0.02 RGD1563216 XM_576075 0.08 0.01 RGD1563226 ENSRNOT00000035153 0.09 0.000395 RGD1563235 EV765652 -0.07 0.00000863 RGD1563352 ENSRNOT00000012694 -0.12 0.02 RGD1563425 ENSRNOT00000049512 -0.09 0.01 RGD1563482 ENSRNOT00000001421 0.08 0.04 RGD1563550 ENSRNOT00000010435 0.12 0.05 RGD1563612 ENSRNOT00000011395 -0.39 2.63E-17 RGD1563680 ENSRNOT00000006177 0.08 0.00283 RGD1563853 ENSRNOT00000026653 -0.08 0.00962 RGD1563941 ENSRNOT00000007754 0.07 0.04 RGD1563952 XM_001071071 0.07 0.0000205 RGD1563958 ENSRNOT00000048460 0.07 0.02 RGD1564209 XM_001053896 -0.12 0.00225 RGD1564304_predicted ENSRNOT00000045312 -0.08 0.05 RGD1564380 ENSRNOT00000051671 -0.06 0.04 RGD1564456 ENSRNOT00000048933 -0.09 0.000806 RGD1564552 XM_001068883 -0.17 0.000124 RGD1564799 DY471778 -0.28 9.17E-11 Diabetes Page 116 of 288

RGD1564811 ENSRNOT00000006325 -0.1 0.00857 RGD1565002 ENSRNOT00000007645 0.05 0.04 RGD1565007 XM_345227 0.08 0.04 RGD1565030 XM_001064873 0.03 0.00997 RGD1565033 XM_573212 0.09 0.000485 RGD1565052 NM_001044696 0.17 0.03 RGD1565247 ENSRNOT00000023642 -0.07 0.000422 RGD1565310 ENSRNOT00000061677 -0.08 0.00752 RGD1565316 XM_001074890 0.04 0.04 RGD1565496 ENSRNOT00000041915 -0.06 0.04 RGD1565561 ENSRNOT00000059774 0.09 0.00479 RGD1565648 ENSRNOT00000055510 0.12 0.00821 RGD1565655 ENSRNOT00000035648 0.09 0.04 RGD1565688 ENSRNOT00000027802 0.05 0.03 RGD1565784 ENSRNOT00000047111 0.03 0.03 RGD1566149 XM_573150 0.08 0.0000272 RGD1566202 ENSRNOT00000046472 0.06 0.03 RGD1566265 BQ200454 0.09 0.00487 RGD1566273 XM_577997 0.07 0.00663 RGD1566320 ENSRNOT00000055588 0.1 0.000692 RGD1566325 ENSRNOT00000024149 -0.18 0.00658 RGD1566386 XM_001074662 -0.08 0.04 RGD708545 NM_001033971 0.07 0.02 RGD735065 NM_199379 -0.04 0.00951 RGD735112 NM_199391 0.09 0.00314 RGD735140 NM_198779 -0.11 0.02 Rgl1 703856458J1 0.06 0.02 Rgs17 ENSRNOT00000025355 0.04 0.03 Rgs8 DV716670 -0.07 0.02 Rhbdl2 XM_001055537 -0.05 0.05 Rhobtb2 NM_001013133 0.1 0.00133 Rhoq NM_053522 -0.13 2.58E-08 Rilpl1 ENSRNOT00000001401 -0.06 0.03 Rims1 NM_052829 0.06 0.04 Rin2 ENSRNOT00000013957 -0.12 0.04 Riok2 NM_001009687 0.05 0.00261 Riok3 ENSRNOT00000039377 0.04 0.00174 Ripk4 XM_001055952 -0.08 0.02 Ripk5 NM_199463 -0.1 0.00114 Rkhd2 XM_001062342 -0.21 3.13E-27 Rmi1 ENSRNOT00000025812 -0.09 0.000697 NM_001010953 0.1 0.02 Rnd3 AA859776 0.09 0.03 Rnf11l ENSRNOT00000021681 0.06 0.01 Rnf125 ENSRNOT00000021136 -0.08 0.0000234 Rnf135 NM_001012010 -0.21 1.79E-09 Rnf138 NM_053588 -0.23 4.45E-14 Page 117 of 288 Diabetes

Rnf139 ENSRNOT00000011891 0.08 0.00038 rnf141 NM_001001800 -0.13 0.000724 Rnf181 NM_001007647 0.05 0.04 Rnf19a CB545346 -0.11 1.58E-14 Rnf217 XM_001057827 0.06 0.04 Rnf32 NM_001012095 -0.15 0.0055 Rnf34 NM_001004075 -0.06 0.00209 Rnf8 NM_001025727 -0.09 0.01 Rnmt NM_001008299 -0.31 0 Rnps1 NM_001011890 -0.19 2.08E-16 Rnuxa NM_173133 -0.1 0.000174 Rock2 703954794J1 -0.19 0.000994 Rpl28 NM_022697 0.04 0.01 Rpl7l1 ENSRNOT00000021803 0.05 0.01 Rpo1-1 NM_001008330 0.08 0.000737 Rpo1-2 NM_031773 0.05 0.01 Rps11 NM_031110 -0.08 0.0000112 Rps19bp1 ENSRNOT00000024085 0.03 0.05 Rps6ka3 ENSRNOT00000008938 0.04 0.05 Rraga NM_053973 0.05 0.00795 RragB 702955022H1 -0.21 0.00477 Rragc NM_001048184 -0.17 3.45E-11 Rras2 NM_001013434 -0.37 2.12E-29 Rrn3 BC086552 -0.06 0.02 Rrp9 XM_001071554 0.06 0.02 Rsrc1 NM_001014172 -0.07 0.01 RT1-Db1 NM_001008884 0.07 0.00445 Rtel1 ENSRNOT00000055028 -0.14 0.00014 Rtf1 XM_001080858 -0.08 0.04 Rtn3 NM_080909 -0.15 6.02E-12 Rtn4 NM_031831 -0.07 0.000000199 Rtp1 ENSRNOT00000032383 -0.06 0.05 Rttn ENSRNOT00000058160 -0.11 0.01 Ruvbl1 NM_147177 0.06 0.00198 Ruvbl2 NM_001025405 0.04 0.00238 Ry1 ENSRNOT00000048399 0.04 0.03 Sacs 702958179J1 0.1 0.05 Samd10 BC099100 0.08 0.000751 Sap130 ENSRNOT00000022761 0.05 0.03 Sap30bp ENSRNOT00000007362 0.04 0.03 Sap30l ENSRNOT00000003473 -0.18 0.000076 Sars2 ENSRNOT00000027166 -0.06 0.0025 Sart3 ENSRNOT00000000891 -0.21 2.9E-30 Scamp1 ENSRNOT00000014602 -0.09 2.17E-09 Scap NM_001100966 -0.1 0.000898 Scn3b NM_139097 -0.15 0.000000017 Scnn1a U54699 0.06 0.04 Diabetes Page 118 of 288

Scoc NM_001013235 0.05 0.0000677 Sdad1 NM_001006958 0.06 0.02 Sdf2 ENSRNOT00000016297 0.04 0.01 Sdha NM_130428 0.04 0.02 Sec14l1 ENSRNOT00000003690 0.08 0.05 Sec14l2 NM_053801 0.1 0.00195 Secisbp2 NM_024002 -0.05 0.00327 Sema4a NM_001012078 -0.08 0.00132 Sema4b ENSRNOT00000030914 -0.19 0.000581 Sema4f NM_019272 0.07 0.00121 Sema6a ENSRNOT00000005476 -0.09 0.00105 Senp7 ENSRNOT00000044177 -0.24 1.32E-12 Sephs1 BG668465 -0.23 1.06E-34 Sephs2 NM_001079889 0.06 0.00235 Serac1 XM_574308 0.08 0.04 Serf2 NM_001098782 0.18 1.72E-10 Serpini1 NM_053779 0.09 0.01 Sesn1 ENSRNOT00000000330 0.07 0.02 Sfpq 704240832J1 -0.32 1.64E-15 Sfrs1 DV721035 -0.21 1.86E-13 Sfrs12ip1 NM_001008373 0.08 0.00234 Sfrs3 NM_001047907 -0.25 6.07E-26 Sfrs6 DV724358 -0.05 0.00206 Sfrs9 NM_001009255 0.04 0.00156 Sft2d1 NM_001008302 0.06 0.000386 Sft2d2 NM_001034011 -0.06 0.01 Sft2d3 XM_001059433 0.12 0.000459 Sfxn2 CK226786 0.06 0.02 Sfxn3 NM_022948 0.06 0.0077 Sgk3 XM_001060531 -0.24 0.000000412 Sh2b3 NM_031621 0.09 0.00969 Sh3gl2 ENSRNOT00000008999 0.12 0.01 Shh NM_017221 0.11 0.04 Shoc2 NM_001013155 -0.13 0.00621 Shpk NM_001033682 -0.12 0.00256 Sidt2 ENSRNOT00000024240 0.05 0.02 Sirt1 ENSRNOT00000000427 -0.11 0.02 Sirt5 NM_001004256 0.06 0.03 Skip NM_001013859 -0.04 0.03 Slain2 XM_001076917 -0.32 1.34E-14 Slc16a1 NM_012716 0.17 0.0000467 Slc16a6 NM_198760 -0.12 0.04 Slc18a2 NM_013031 -0.11 0.03 Slc1a1 D63772 -0.19 0.000000546 Slc20a1 NM_031148 -0.1 0.000849 Slc24a5 ENSRNOT00000043611 0.12 0.00712 Slc24a6 NM_001017488 -0.14 0.0000308 Page 119 of 288 Diabetes

Slc25a14 NM_053501 0.08 0.0000237 Slc25a16 ENSRNOT00000029576 0.08 0.00312 Slc25a19 NM_001007674 0.08 0.02 Slc25a20 X97831 -0.64 4.62E-29 Slc25a22 NM_001014027 0.07 0.04 Slc25a25 NM_145677 0.09 0.01 Slc25a37 NM_001013996 0.09 0.000295 Slc29a3 NM_181639 0.07 0.04 Slc2a6 ENSRNOT00000008034 -0.15 0.00000138 Slc30a4 NM_172066 0.06 0.01 Slc31a1 NM_133600 -0.05 0.01 Slc31a2 NM_001033693 0.06 0.03 Slc35a3 NM_001012082 0.12 0.000861 Slc35a4 NM_147140 0.05 0.00116 Slc35a5 XM_001066912 -0.08 0.02 Slc35b3 ENSRNOT00000021669 -0.05 0.03 Slc35c1 ENSRNOT00000010278 0.12 0.0000345 Slc35e1 703865440J1 0.07 0.00537 Slc35e3 BC091412 0.06 0.01 Slc35f5 ENSRNOT00000004581 0.07 0.00182 Slc38a2 NM_181090 -0.12 0.000544 Slc38a9 NM_001035251 0.07 0.00471 Slc3a2 NM_019283 -0.1 0.000782 Slc41a2 ENSRNOT00000011572 0.06 0.02 Slc45a4 ENSRNOT00000032620 0.06 0.02 Slc5a3 NM_053715 -0.21 0.00000852 Slc7a5 NM_017353 -0.22 0.0014 Slc7a6 ENSRNOT00000027117 0.07 6.83E-08 Slc9a2 NM_012653 0.08 0.00343 Slc9a6 ENSRNOT00000001171 0.07 0.04 Slit2 ENSRNOT00000005477 -0.15 0.03 Slitrk5 ENSRNOT00000057692 0.1 0.02 Slk CK228000 -0.13 0.000113 Smad4 AF056002 -0.14 0.0000111 Smarca5 CA504468 -0.09 0.000262 Smarcd2 NM_031983 0.06 0.00331 Smarce1 NM_001024993 0.05 0.05 Smcr7l NM_001007709 0.15 0.03 Smn1 NM_022509 0.07 0.0000119 Smpd1 NM_001006997 -0.26 5.03E-14 Smpd3 NM_053605 -0.05 0.01 Smurf2 ENSRNOT00000019781 0.11 0.00633 Snapap AA799709 0.05 0.0067 Snca NM_019169 0.1 0.000761 Snf1lk ENSRNOT00000001579 0.25 4.62E-16 Snip1 NM_001014069 0.05 0.04 Snrpc ENSRNOT00000000586 0.03 0.02 Diabetes Page 120 of 288

Sntg1 ENSRNOT00000009679 0.14 0.03 Snx1 NM_053411 0.07 0.01 Snx16 NM_022289 0.16 4.13E-10 Snx17 NM_001011981 0.03 0.05 Snx27 BM388706 -0.29 2.37E-13 Snx4 ENSRNOT00000002432 -0.11 0.000000148 Snx7 NM_001012083 0.07 0.00381 Snx8 ENSRNOT00000001696 0.11 0.02 Soat1 704244751J1 0.08 0.02 Socs2 NM_058208 -0.19 0.01 Socs6 XM_001063512 0.05 0.01 Sod2 BQ782213 -0.31 0.00992 Sorcs3 BF409626 0.14 0.00643 Sos1 XM_001062567 -0.15 0.00026 Spag4 NM_031792 0.07 0.01 Spast ENSRNOT00000039375 0.06 0.04 Spata9 ENSRNOT00000017068 -0.06 0.03 Spc25 NM_001009654 -0.07 0.01 Spg20 XM_215564 -0.04 0.04 Sphk2 NM_001012066 0.05 0.03 Spin2 ENSRNOT00000052281 0.08 0.00161 Sppl3 BQ781686 -0.07 0.00267 Spred1 ENSRNOT00000007028 -0.22 0.0005 Spry1 ENSRNOT00000058495 -0.14 0.00548 Spryd3 ENSRNOT00000055320 -0.15 0.0000495 Spryd4 NM_001037765 -0.04 0.03 Sptlc1 ENSRNOT00000014546 0.06 0.000629 Sqle NM_017136 0.06 0.03 Srd5a3 NM_001013990 0.04 0.03 Srf ENSRNOT00000061430 0.07 0.00141 Srrm2 CA509585 0.08 0.000905 Ssfa2 ENSRNOT00000008046 0.06 0.02 Ssx2ip NM_175597 -0.43 0 St3gal5 CK473297 0.06 0.02 St5 XM_219273 -0.1 0.00732 St6gal1 NM_147205 -0.09 0.01 Stard7 XM_238280 0.05 0.0000243 Stim2 ENSRNOT00000058996 -0.17 0.00211 Stk3 NM_031735 0.06 0.02 Strap NM_001011969 -0.04 0.00924 Strbp ENSRNOT00000013832 0.05 0.02 Strn NM_019148 -0.13 0.0000484 Sucla2 ENSRNOT00000023516 -0.15 0.00000447 Sulf1 NM_134378 0.11 0.03 Sumf1 ENSRNOT00000009008 0.08 0.0019 Sv2a NM_057210 -0.29 0.000000098 Syngr4 NM_001025644 0.07 0.03 Page 121 of 288 Diabetes

Synj1 NM_053476 -0.05 0.03 Synj2bp NM_022599 -0.11 0.0000241 Synpo2 ENSRNOT00000019931 0.1 0.04 Taar8b NM_175601 -0.12 0.05 Tac2 NM_019162 0.07 0.04 Tacc2 NM_001004418 -0.07 0.01 Tada2l NM_001012141 -0.06 0.01 Taf11 NM_001008350 -0.08 0.02 Taf2 ENSRNOT00000040836 -0.07 0.02 Taf6l ENSRNOT00000026284 0.07 0.03 Taf7 ENSRNOT00000027125 0.08 0.03 Taf9b NM_133615 0.07 0.000418 Tagln3 NM_001035236 0.08 0.02 Tas1r2 AI103143 -0.11 0.03 Tasp1 XM_001080195 0.04 0.03 Tbc1d10b ENSRNOT00000023706 0.06 0.02 Tbc1d15 ENSRNOT00000005207 -0.06 0.000222 Tbc1d2 ENSRNOT00000011714 0.09 0.04 Tbc1d7 ENSRNOT00000019089 -0.06 0.01 Tbl3 NM_001008277 -0.07 0.02 Tbr1 ENSRNOT00000007024 0.08 0.03 Tbx2 ENSRNOT00000004698 0.07 0.04 Tbx5 NM_001009964 0.07 0.04 Tc2n NM_001025152 0.09 0.0000175 Tceb1 BC060566 -0.12 0.000506 Tceb3 NM_017103 0.09 0.00368 Tcf20 XM_001077683 -0.04 0.03 Tcf21 NM_001032397 0.07 0.03 Tcp11l2 NM_001017458 -0.07 0.03 Tdrd7 NM_138871 -0.33 6.43E-22 Tect2 NM_001080782 -0.1 2.31E-11 Terf1 NM_001012464 -0.09 0.02 Tex15 g11396596 0.14 0.05 Tex264 NM_001007665 -0.27 2.34E-33 Tex9 ENSRNOT00000032268 0.06 0.00708 Tfb1m NM_181474 0.07 0.04 Tgfbr1 NM_012775 -0.09 0.03 Thap1 NM_001008340 -0.07 0.04 Timm8b NM_022541 0.05 0.01 Timm9 ENSRNOT00000010871 -0.43 0 Tipin NM_001025287 -0.15 1.38E-17 Tle4 NM_019141 -0.12 0.00485 Tlk1 g4237793 0.1 0.03 Tm2d2 NM_001017444 0.04 0.02 Tm9sf2 NM_001005554 0.03 0.01 Tmcc3 ENSRNOT00000010316 0.06 0.03 Tmco3 ENSRNOT00000026281 -0.04 0.02 Diabetes Page 122 of 288

Tmed1 NM_001013432 0.07 0.00605 Tmed9 NM_001009703 0.06 0.00573 Tmem106b NM_001004267 0.07 0.000629 Tmem109 NM_001007736 -0.04 0.03 Tmem123 NM_001014205 0.11 0.000717 Tmem126b ENSRNOT00000038279 0.05 0.04 Tmem135 NM_001013896 -0.08 0.00000159 Tmem141 ENSRNOT00000033701 0.04 0.03 Tmem14a ENSRNOT00000037489 0.08 0.00276 Tmem150 NM_139107 0.05 0.04 Tmem157 NM_001012350 0.06 0.04 Tmem161b ENSRNOT00000045851 -0.17 0.000000541 Tmem165 NM_001024802 0.05 0.0000104 Tmem168 NM_001014054 -0.07 0.02 Tmem175 NM_001013991 0.06 0.00875 Tmem177 NM_001037776 0.08 0.00397 Tmem188 ENSRNOT00000020816 0.08 0.02 Tmem189 703893835J1 0.08 0.000627 Tmem19 NM_199098 0.05 0.01 Tmem192 NM_001014141 -0.09 0.00218 Tmem199 NM_001024992 0.05 0.00254 Tmem2 ENSRNOT00000017212 -0.2 5.35E-09 Tmem30a DV718956 -0.29 3.05E-24 Tmem32 XM_001057974 -0.23 1.64E-08 Tmem34 NM_178330 0.06 0.00848 Tmem35 NM_001001799 0.11 0.01 Tmem38b NM_001014191 0.12 0.00015 Tmem43 NM_001007745 -0.14 0.00239 Tmem49 NM_138839 0.05 0.00856 Tmem55b NM_001014233 -0.17 0.00043 Tmem59l ENSRNOT00000038139 0.07 0.05 Tmem77 NM_001025018 0.04 0.01 Tmem87b ENSRNOT00000023569 0.07 0.04 Tmem9 ENSRNOT00000013738 -0.36 1.61E-43 Tmem93 ENSRNOT00000026168 -0.23 8.91E-30 Tmem97 NM_001008334 0.06 0.02 Tmod2 NM_031613 -0.18 2.54E-08 Tmpo NM_012887 -0.12 0.0000182 Tnfrsf21 ENSRNOT00000015918 0.07 0.03 Tob2 NM_001007146 0.11 0.00482 Tomm70a NM_212519 0.04 0.01 Top1 BE115617 0.09 0.000328 Tor2a NM_001007744 0.06 0.05 Tor3a NM_001009683 0.08 0.000196 Tpcn1 NM_139332 0.14 0.00545 Traf6 DY472844 -0.17 0.000107 Trappc3 NM_001008376 0.05 0.04 Page 123 of 288 Diabetes

Trappc4 NM_001003708 0.05 0.00267 Trem2 ENSRNOT00000018351 0.08 0.00824 Trim10 NM_001009176 -0.12 0.00168 Trim25 NM_001009536 -0.2 1.15E-09 Trim37 XM_001081108 -0.31 1.39E-28 Trim47_predicted ENSRNOT00000040703 -0.06 0.05 Trip13 NM_001011930 -0.13 0.0000216 Trmu ENSRNOT00000022511 -0.05 0.02 Trp53i11 ENSRNOT00000057001 -0.09 0.00109 Trpv6 NM_053686 -0.07 0.00547 Trub1 NM_001012173 -0.09 0.00000574 Tsc22d1 ENSRNOT00000058206 -0.06 0.04 Tsc22d3 NM_031345 -0.33 3.94E-13 Tsen34 NM_001006968 -0.12 1.93E-08 Tsn NM_021762 -0.27 6.28E-11 Tspyl1 NM_001013033 0.04 0.02 Tspyl4 NM_001012075 -0.08 0.04 Ttc12 NM_001004246 -0.06 0.000528 ttc21a ENSRNOT00000043831 0.09 0.04 Ttc35 ENSRNOT00000006890 -0.07 0.00244 Ttc7b ENSRNOT00000037902 -0.13 0.000062 Ttc9c NM_001007693 0.06 0.00578 Ttll6 ENSRNOT00000006594 0.08 0.00682 Tuba1c NM_001011995 0.03 0.02 Tusc1 ENSRNOT00000030683 -0.16 0.00214 Twist1 NM_053530 -0.32 1.04E-10 Twistnb XM_001076417 -0.23 0.0000158 Txndc1 NM_001024800 -0.13 0.00231 Txndc12 ENSRNOT00000010700 0.07 0.000000173 Txndc15 NM_001024998 -0.15 4.14E-18 Txnl1 NM_080887 -0.1 0.00101 Txnrd1 NM_031614 -0.24 1.33E-09 Tyw3 ENSRNOT00000032874 0.05 0.04 Uba3 NM_057205 -0.2 2.51E-15 Ubap1 NM_001012190 -0.1 0.00622 Ube2c ENSRNOT00000020323 0.03 0.00338 Ube2cbp NM_001039610 -0.07 0.04 Ube2d1 XM_001080152 -0.13 0.00000537 Ube2d3 ENSRNOT00000051335 -0.14 1.62E-10 Ube2e2 BC079134 0.05 0.0084 Ube2f NM_001008381 0.04 0.05 Ube2g1 BM986416 0.08 0.02 Ube2q1 ENSRNOT00000028210 0.09 0.000000243 Ube2t ENSRNOT00000006747 0.07 0.0000354 Ube2v2 NM_183052 -0.21 4.44E-09 Ube3a CO563495 0.06 0.00105 Ublcp1 704251230J1 0.11 0.000119 Diabetes Page 124 of 288

Ubqln4 ENSRNOT00000026994 0.08 0.02 Ugcg NM_031795 0.11 0.00881 Ugp2 NM_001024743 0.04 0.0069 Uhrf1 NM_001008882 -0.1 0.00000893 Uqcrh NM_001009480 0.04 0.04 Usp14 NM_001008301 -0.13 2.5E-10 Usp25 ENSRNOT00000002150 -0.05 0.03 Usp28 ENSRNOT00000009724 0.07 0.02 Usp39 ENSRNOT00000015562 0.06 0.02 Usp45 XM_001058981 0.1 0.03 Usp48 NM_198785 -0.08 0.00231 Usp9x CK839458 -0.15 0.000126 Utp6 DY471469 0.07 0.01 Utrn NM_013070 -0.09 0.000259 Uxs1 NM_139336 0.11 0.00000593 Vamp3 NM_057097 0.1 0.000196 Vcl XM_223781 0.1 0.00686 Vdac2 NM_031354 -0.12 0.00000117 Vegfa NM_031836 -0.17 0.000902 Vegfc NM_053653 0.1 0.04 Veph1 BI295726 0.1 0.04 Vgll2 ENSRNOT00000000456 0.05 0.05 Visa NM_001005556 0.07 0.03 Vkorc1l1 NM_203338 0.06 0.00849 Vps13a CF115472 -0.11 0.000379 Vps16 NM_001005541 -0.05 0.02 Vps26a NM_001007740 0.09 0.0000323 Vps26b 704158379J1 -0.08 0.000117 Vps37a NM_001024867 0.05 0.00755 Vps37b ENSRNOT00000001445 -0.21 0.000021 Vps52 CR470235 -0.12 0.01 Vrk1 NM_001012194 -0.3 3.2E-31 Vsnl1 NM_012686 0.1 0.00391 Wbp11 NM_001009661 0.05 0.00678 Wdfy1 NM_001008331 -0.12 0.0000694 Wdr26 g3730315 -0.07 0.000351 Wdr43 ENSRNOT00000035320 -0.05 0.03 Wdr47 ENSRNOT00000027558 -0.15 0.000000832 Wdr49 ENSRNOT00000039524 -0.1 0.02 Wdr77 NM_001008771 -0.07 0.03 Wdsof1 ENSRNOT00000005803 0.03 0.03 Wfs1 NM_031823 0.14 0.01 Wisp2 NM_031590 -0.09 0.04 Wrb NM_199373 -0.34 0 Wscd1 NM_001024234 -0.05 0.04 Wwp2 XM_001076615 -0.15 0.0000919 Xkr8 NM_001012099 0.16 0.000637 Page 125 of 288 Diabetes

Xpa ENSRNOT00000012779 -0.19 0.00113 Xpnpep1 NM_131913 0.03 0.03 Yod1 NM_001008889 -0.1 0.02 Ypel5 NM_001035221 -0.08 0.03 Yrdc NM_175604 -0.22 1.51E-20 Ywhaz NM_013011 0.05 0.03 Yy1 NM_173290 0.04 0.05 Zadh1 NM_001015009 -0.07 0.03 Zbed3 NM_001025729 0.07 0.00143 Zbtb1 NM_001004444 -0.18 6.98E-08 Zbtb17 NM_001012105 -0.12 0.000565 Zbtb20 703080592T1 -0.28 5.18E-18 Zbtb44 NM_001034942 -0.24 3.29E-08 Zbtb5 BC086334 0.06 0.04 Zc3h14 NM_001033951 -0.07 0.0069 Zcchc11 XM_001060286 -0.15 5.61E-25 Zcchc3 ENSRNOT00000009859 0.11 0.03 Zcrb1 BI281998 0.05 0.00462 Zdhhc11 BC105834 0.08 0.04 Zdhhc12 NM_001013239 0.11 0.0000269 Zdhhc13 NM_001039037 0.06 0.00546 Zdhhc16 NM_001039346 0.07 0.00153 Zdhhc4 NM_001013123 0.06 0.00137 Zdhhc7 NM_133394 -0.13 0.0000114 Zeb2 NM_001033701 0.11 0.03 Zfand1 ENSRNOT00000013905 0.09 0.00317 Zfp110 NM_001024775 0.08 0.01 Zfp207 NM_001039020 -0.1 0.0000091 Zfp238 NM_022678 -0.14 0.0000961 Zfp259 ENSRNOT00000025149 0.05 0.03 Zfp292 NM_001008879 -0.05 0.02 Zfp296 XM_345065 -0.09 0.00254 Zfp593 ENSRNOT00000021937 0.07 0.00608 Zfp644 ENSRNOT00000002882 -0.12 0.000456 Zfp667 NM_001008557 0.07 0.00143 Zfp703 ENSRNOT00000019002 0.08 0.02 Zfp91 ENSRNOT00000016804 0.1 0.00943 Zfyve1 ENSRNOT00000011662 -0.07 0.03 Zfyve26 CA503756 0.13 0.02 Zhx1 NM_133620 -0.34 7.71E-18 Zmym6 ENSRNOT00000038888 0.05 0.00887 Znf532 ENSRNOT00000023048 -0.08 0.03 Znhit3 ENSRNOT00000039481 0.05 0.03 Znrf1 ENSRNOT00000051594 -0.3 0.0000133 Zp3r NM_182815 0.09 0.01 Zrsr1 BF404554 0.12 0.05 Zswim1_predicted XM_230846 0.07 0.0000479 Diabetes Page 126 of 288

Zswim3 ENSRNOT00000021052 -0.08 0.04 Zswim6 XM_001073593 -0.18 4.06E-09 Zzef1 XM_237787 0.11 0.000959 ENSRNOT00000049857 -0.51 0 Page 127 of 288 Diabetes

mRNAs colored red contain seed region against both miRNA-132 and 212 Diabetes Page 128 of 288

Gene Symbol Accession Number Log(Ratio) P-value March3 NM_001007759 0.27 1.14E-05 mRNAs colored red contain seed region against both miRNA-132 and 212 Aacs XM_236790 -0.1 0.01 Aasdhppt CB797262 0.14 1.55E-04 Aatf ENSRNOT00000008062 0.04 0.01 Abcb6 NM_053720 0.07 2.80E-03 Abcb8 702966435H1 -0.1 0.04 Abce1 NM_080582 0.12 0.03 Abcf1 ENSRNOT00000024753 0.13 5.24E-06 Abcf2 CK359266 0.12 8.96E-04 Abhd10 ENSRNOT00000014718 0.07 0.03 Abhd12 ENSRNOT00000048533 0.08 9.36E-04 Abhd13 NM_001024314 0.1 1.24E-03 Abhd14b ENSRNOT00000019563 0.05 0.02 Abhd2 ENSRNOT00000026321 -0.11 3.80E-05 Abhd3 NM_001007664 0.05 0.02 Abhd6 ENSRNOT00000041878 0.14 1.07E-03 Abi2 NM_012514 -0.12 1.06E-07 Abl1 ENSRNOT00000012490 -0.09 3.67E-03 Ablim2 NM_017223 -0.07 0.02 Abo_predicted NM_001007680 0.05 0.05 Abr NM_031066 -0.12 1.66E-03 Abt1 ENSRNOT00000061276 0.13 1.38E-04 Abtb1 ENSRNOT00000039593 -0.09 0.05 Acaa2 ENSRNOT00000019556 -0.08 8.55E-04 Acbd6 ENSRNOT00000021432 0.15 7.04E-06 Accn1 DN948071 -0.07 9.72E-03 Acd ENSRNOT00000023649 0.12 4.70E-05 Acly ENSRNOT00000011683 -0.1 0.04 Aco2 NM_001037193 0.1 1.94E-04 Acot8 AJ243266 0.05 0.04 Acox1 NM_130756 0.07 0.03 Acsl5 ENSRNOT00000042372 0.07 0.05 Actr3b DQ294702 -0.11 0.03 Actr5 NM_053607 0.11 3.40E-05 Actr8 ENSRNOT00000034284 -0.07 0.03 Acvr2a ENSRNOT00000041276 0.09 2.64E-04 Acyp1 NM_031571 0.07 6.36E-03 Ada ENSRNOT00000009086 0.09 7.92E-04 Adam9 NM_020306 0.13 4.93E-04 Adarb1 NM_173133 -0.09 2.07E-03 Adcy6 NM_001034932 -0.1 4.06E-03 Adcy8 NM_001014772 0.08 0.04 Adcyap1 NM_017142 0.17 5.28E-07 Adfp ENSRNOT00000025491 -0.12 1.13E-06 Adh4 ENSRNOT00000058689 -0.09 7.86E-04 Adnp2 BC128697 0.07 2.79E-03 Page 129 of 288 Diabetes

Adprhl2 ENSRNOT00000000791 0.08 6.52E-03 Adrbk2 ENSRNOT00000037902 -0.1 0.02 Afg3l1 DY309260 0.07 0.03 Afg3l2 BF523513 0.1 7.55E-03 Agpat2 BC091419 0.07 0.02 Agpat5 ENSRNOT00000026408 0.23 3.90E-10 Agpat6 703889388J1 0.15 0.02 Aifm1 CX570492 0.14 9.35E-09 Aig1 NM_012543 -0.11 6.91E-03 Akap10_predicted ENSRNOT00000054884 -0.08 0.03 Akap8l ENSRNOT00000024392 0.08 4.46E-05 Akr1c19 NM_031356 0.06 2.09E-04 Alad BE102687 0.17 1.04E-04 Aldh1l2 NM_001100576 0.08 2.82E-04 Aldob NM_012899 0.12 1.33E-03 Alg10b XM_235005 0.1 8.53E-03 Alg11 NM_012496 0.1 0.01 Alg12 NM_139101 0.07 0.03 Alg14 XM_001073524 -0.1 9.88E-03 Alg5 ENSRNOT00000017164 0.11 4.00E-08 Alg9 ENSRNOT00000006139 0.12 1.15E-05 Alkbh6 NM_001025407 0.12 1.45E-09 Alpk3 ENSRNOT00000029137 0.08 1.61E-04 Amfr ENSRNOT00000051259 0.03 0.05 Amhr2 CK355531 0.09 0.04 Ampd2 NM_033443 -0.05 0.04 Anapc1 ENSRNOT00000000049 0.1 0.03 Angptl6 NM_133591 -0.07 2.17E-03 Ank CV116197 0.06 6.46E-03 Ankmy2 NM_030998 0.09 2.29E-03 Ankrd39 NM_053714 0.08 2.44E-03 Ankrd46 ENSRNOT00000007562 0.1 0.01 Ankrd50 ENSRNOT00000026382 -0.09 4.12E-03 Ankrd56 ENSRNOT00000021685 0.18 2.03E-05 Ankrd57 NM_001013948 0.05 0.02 Ankrd9 BF394727 0.06 0.04 Anp32a CB696160 -0.53 4.87E-12 Anp32b NM_001004250 0.07 4.00E-03 Anpep DY318217 0.16 9.11E-04 Anxa2 NM_053948 -0.07 4.01E-05 Anxa4 XM_001071055 -0.12 1.09E-06 Anxa7 NM_001012112 0.14 0.02 Ap1g1 NM_031012 0.09 8.82E-03 Ap1s1 NM_130416 0.09 0.04 Ap1s2 ENSRNOT00000051859 0.14 7.94E-05 Ap2s1 ENSRNOT00000001918 0.1 2.65E-03 Ap3b1 XM_001068004 0.09 0.02 Diabetes Page 130 of 288

Ap3b2 NM_001014157 -0.07 9.96E-03 Ap3m1 NM_022952 0.06 4.52E-03 Ap3s1 L07073 0.05 0.03 Apba2 ENSRNOT00000021937 0.11 1.07E-06 Api5 NM_053497 -0.09 0.04 Appbp2 ENSRNOT00000038161 -0.11 0.03 Aprt ENSRNOT00000005222 0.05 0.02 Aqp11 NM_001047090 0.09 6.54E-03 Aqp7 NM_001013061 0.06 7.74E-03 Arbp ENSRNOT00000023305 0.12 1.15E-03 Ard1 NM_173105 0.16 3.17E-03 Arf4 NM_019157 0.08 0.04 Arfip2 NM_001007662 0.05 0.03 Arhgef12 NM_031806 -0.1 0.03 Arhgef5 ENSRNOT00000051254 0.12 1.62E-05 Arhgef7 NM_024151 0.06 0.03 Arhgef9 NM_023957 -0.28 1.59E-03 Arid3b NM_001004222 0.07 0.04 Arid4a AA998145 0.05 0.05 Arid4b ENSRNOT00000011424 -0.08 0.05 Arih1 NM_001013108 -0.09 3.49E-03 Arl4a AI704172 0.09 0.01 Arl8b XM_001074513 0.17 0.01 Armc10 BC099224 -0.09 0.03 Armc6 NM_053594 -0.07 0.04 Arpc1b BF389735 0.11 0.01 Arpm1 NM_019186 0.08 0.04 Arsi NM_001024332 0.06 1.09E-03 Asah1 NM_019289 0.14 5.15E-06 Asah3 NM_199383 0.06 0.04 Asahl ENSRNOT00000030700 0.16 2.20E-03 Asb1 NM_053407 0.04 0.04 Asb9 NM_053589 -0.06 0.02 Asf1a NM_001010967 0.22 2.74E-07 Asl ENSRNOT00000027528 0.08 0.03 Atad3a BF408633 0.06 0.01 Atad5 ENSRNOT00000006964 0.12 2.40E-06 Atg12 ENSRNOT00000037998 -0.1 0.03 Atg3 NM_021577 0.11 5.73E-03 Atg7 NM_001025727 -0.09 1.77E-03 Atox1 ENSRNOT00000012381 -0.11 0.01 Atp10a NM_001034922 0.08 6.70E-03 Atp11a NM_130399 0.18 1.20E-06 Atp1a2 NM_134394 0.06 8.38E-03 Atp1b1 BC107909 0.17 0.03 Atp2a2 M63006 0.08 9.21E-03 Atp2a3 ENSRNOT00000020154 -0.09 0.02 Page 131 of 288 Diabetes

Atp5f1 AW530918 0.16 1.76E-03 Atp5g3 BP494233 -0.08 0.01 Atp5o NM_012505 0.19 6.07E-04 Atp6ap2 M14137 0.09 9.36E-04 Atp6v0a1 NM_012913 0.06 5.87E-05 Atp6v0b ENSRNOT00000024347 0.09 1.58E-05 Atp6v0d1 NM_134365 0.05 0.03 Atp6v1a1 704291381J1 -0.09 5.37E-03 Atp6v1b2 ENSRNOT00000020695 -0.11 0.02 Atp7a NM_138883 0.06 0.03 Atp8b1 ENSRNOT00000005138 0.06 1.33E-04 Atp9b ENSRNOT00000005267 -0.11 8.81E-05 Atpbd1c BF402761 0.17 0.04 Auh ENSRNOT00000006199 -0.1 9.24E-03 Aup1 ENSRNOT00000026704 0.05 0.04 Avpi1 NM_001011927 0.05 0.01 Azin1 XM_001081737 -0.05 0.02 B3galnt1 NM_052803 0.12 7.70E-03 B3galtl ENSRNOT00000038652 0.12 1.20E-03 B4galnt1 NM_201991 0.13 1.19E-04 B4galt1 NM_001079899 0.12 3.22E-03 B4galt2 ENSRNOT00000046514 -0.08 0.04 B9d1 NM_134373 0.17 1.62E-04 Bace1 NM_001013158 0.07 1.43E-03 Bace2 ENSRNOT00000034549 -0.07 0.01 Bag1 ENSRNOT00000001199 0.09 0.03 Bag5 NM_022860 0.09 0.04 Baiap2l1 ENSRNOT00000010874 0.07 0.04 Barhl2 ENSRNOT00000056798 -0.07 0.05 Batf3 NM_019204 0.11 0.02 Baz2a NM_053758 -0.09 0.03 Bbs2 ENSRNOT00000003728 -0.08 0.02 Bbs4 ENSRNOT00000011455 0.09 3.96E-07 Bcap29 NM_001034140 0.1 6.39E-05 Bckdk NM_001011921 -0.1 0.03 Bdh1 NM_021865 0.08 1.82E-03 Bex2 ENSRNOT00000028210 0.13 1.51E-04 Bfar NM_001004249 -0.1 9.16E-04 Bhlhb2 NM_001025765 -0.12 3.96E-03 Bhlhb8 ENSRNOT00000031262 0.08 4.99E-03 Bicd2 NM_001012076 -0.1 4.82E-03 Bin1 NM_001006980 0.14 0.02 Bin3 ENSRNOT00000013249 0.08 0.03 Bles03 NM_001007666 0.1 0.03 Blmh NM_053995 0.15 3.76E-07 Bmp2 NM_012863 0.13 0.02 Bmp8a BG666928 0.08 9.82E-03 Diabetes Page 132 of 288

Bnip2 BF282292 -0.32 4.08E-22 Bpgm NM_053959 0.1 0.04 Bpnt1 NM_001013186 0.11 5.76E-03 Brca1 ENSRNOT00000001728 -0.06 0.03 Bri3 X53003 -0.12 0.02 Bri3bp NM_001024233 0.14 0.03 Brms1 ENSRNOT00000014278 0.05 7.11E-03 Brp44l NM_001034163 0.1 1.61E-07 Brunol6 NM_017178 0.26 1.11E-03 Brwd3 NM_001011946 -0.05 0.03 Btaf1 ENSRNOT00000054751 0.14 3.91E-05 Btbd10 ENSRNOT00000045922 0.08 0.04 Btg2 BI278296 -0.34 3.32E-16 Btg3 EV764831 0.12 5.61E-05 Btrc NM_171990 0.16 0.04 Bud13 NM_001017487 0.05 0.02 Bud31 XM_001072516 0.1 8.36E-04 Bwk1 NM_133561 0.11 3.47E-06 Bysl XM_236307 0.09 0.03 Bzw1 NM_001014022 0.13 1.38E-03 Bzw2 NM_019290 0.08 7.21E-07 C1ql3 NM_001007148 0.06 0.04 C1qtnf6 NM_172072 0.08 0.02 C4bpb NM_001025277 0.06 0.02 C9 NM_053556 0.05 0.03 Cabc1 NM_001039338 0.07 0.02 Cacna1e NM_198743 0.07 2.11E-03 Cacna1h BP480833 -0.11 0.02 Cacna2d1 NM_134408 -0.08 0.04 Cacnb3 ENSRNOT00000047223 -0.07 0.02 Cacng4 NM_182674 0.09 0.02 Cadps2 NM_001009636 -0.1 9.94E-07 Calb1 AI407864 0.22 5.54E-05 Calu NM_001033898 -0.12 1.90E-03 Caly ENSRNOT00000005803 0.07 2.05E-03 Camk2b NM_001012041 -0.09 2.17E-03 Camk4 ENSRNOT00000007414 0.05 0.03 Capn2 ENSRNOT00000062020 -0.07 3.78E-03 Car11 XM_214968 -0.07 0.02 Car8 NM_024002 -0.05 0.05 Cask NM_001047881 0.09 5.27E-03 Casp6 ENSRNOT00000023637 0.11 2.95E-04 Catsper2 NM_016995 0.12 4.57E-03 Cbfa2t2 g8495105 -0.09 2.58E-03 Cblb BG667702 -0.18 0.04 Cbx1 ENSRNOT00000013071 -0.1 4.65E-04 Ccdc104 NM_057146 0.07 2.52E-03 Page 133 of 288 Diabetes

Ccdc111 L15453 0.11 3.14E-03 Ccdc114 NM_080692 0.12 2.78E-03 Ccdc23 NM_031984 0.18 9.83E-06 Ccdc28a NM_001009658 -0.11 2.30E-03 Ccdc32 NM_012727 0.09 0.04 Ccdc34 g8508223 0.11 1.73E-03 Ccdc43 AI704530 0.13 0.01 Ccdc58 NM_031775 0.14 9.26E-04 Ccdc91 NM_001077673 -0.05 0.03 Ccdc93 BP485207 0.13 3.37E-05 Ccdc94 NM_001024866 0.06 0.02 Ccdc99 ENSRNOT00000029868 0.11 0.04 Cck ENSRNOT00000028662 0.08 0.01 Ccna2 NM_001038992 0.09 0.02 Ccnb2 NM_001024245 0.09 2.16E-04 Ccnd2 700643635F6 -0.1 0.03 Ccnd3 ENSRNOT00000008753 0.08 0.01 Ccndbp1 ENSRNOT00000003685 0.1 7.02E-04 Ccnf ENSRNOT00000042208 0.08 5.07E-03 Ccni NM_001079700 -0.11 0.02 Ccnl2 NM_001024997 0.11 0.02 Ccpg1 NM_001013164 -0.09 1.28E-03 Ccrn4lb BC129098 0.07 0.03 Ccs NM_001034138 0.07 0.01 Cct7 NM_012829 0.14 8.39E-04 Cd164 EV778603 0.07 7.50E-03 Cd1d1 704274525J1 -0.1 1.03E-03 Cd200 NM_053702 0.07 0.03 Cd276 NM_012766 0.24 2.69E-03 Cd320 NM_001013204 0.04 0.04 Cd55 702129857F7 0.12 0.03 Cd59 ENSRNOT00000051945 -0.08 5.27E-03 Cd5l CD370960 0.07 7.68E-04 Cd82 ENSRNOT00000014348 0.07 0.02 Cd83 NM_019371 -0.09 0.05 Cd99l2 NM_053425 0.1 0.03 Cdan1 ENSRNOT00000021030 0.08 2.67E-03 Cdc23 NM_031518 0.17 4.01E-06 Cdc25b ENSRNOT00000003402 0.12 2.55E-03 Cdc25c NM_182824 0.07 0.02 Cdc2a ENSRNOT00000026653 -0.12 9.04E-05 Cdc2l6 NM_012624 -0.07 0.02 Cdc37l1 BC091307 -0.08 0.02 Cdc40 NM_134359 -0.12 1.93E-10 Cdc42ep1 ENSRNOT00000016288 -0.05 0.05 Cdc42ep4 NM_001011936 -0.11 0.01 Cdca2 NM_001008526 0.08 1.40E-03 Diabetes Page 134 of 288

Cdca3 NM_001014201 0.12 5.67E-04 Cdh1 ENSRNOT00000005583 -0.1 2.36E-03 Cdh23 ENSRNOT00000006968 -0.1 0.02 Cdkl3 NM_022269 0.13 0.03 Ceacam1 ENSRNOT00000018922 -0.12 9.76E-05 Cebpd NM_001025685 0.12 9.30E-03 Cebpg ENSRNOT00000024587 -0.1 3.11E-06 Cebpz ENSRNOT00000006824 -0.1 1.90E-03 Cenpi NM_031797 0.11 2.86E-10 Cenpl NM_134459 0.07 0.02 Cenpq ENSRNOT00000014664 0.12 0.02 Cep55 ENSRNOT00000037888 0.13 3.10E-08 Cep70 NM_012930 -0.1 1.63E-08 Cep72 NM_001025730 -0.09 0.04 Cep76 NM_133572 0.16 3.24E-03 Cerk ENSRNOT00000022882 -0.18 1.70E-05 Cetn3 NM_001004264 -0.08 7.36E-04 Cfl2 ENSRNOT00000060771 0.14 5.82E-06 Cflar BC105847 0.14 1.17E-05 Cggbp1 NM_001007648 0.06 4.09E-03 Cgn ENSRNOT00000037483 -0.06 5.82E-03 Cgrrf1 NM_021772 0.17 3.35E-04 Chchd3 NM_013154 0.15 2.09E-03 Chd6 ENSRNOT00000013467 -0.11 4.76E-04 Chdh ENSRNOT00000005911 -0.08 0.03 Chek2 NM_012955 0.11 9.06E-03 Chid1 ENSRNOT00000029531 -0.1 0.01 Chmp6 NM_001033061 0.04 0.02 Chordc1 NM_001014215 0.07 0.03 Chp2 NM_001025646 0.12 3.65E-05 Chtf18 ENSRNOT00000039523 0.13 1.30E-05 Ciapin1 704254915J1 0.12 0.04 Cib2 XM_001079054 0.15 4.33E-09 Cidec ENSRNOT00000056932 -0.07 4.99E-03 Cipar1 ENSRNOT00000048797 -0.11 0.02 Cirbp NM_031654 -0.12 4.78E-04 Cirh1a NM_057138 0.13 1.50E-03 Cisd1 ENSRNOT00000000909 0.08 9.13E-03 Ckap4 NM_053899 0.1 1.19E-03 Ckb XM_238346 0.07 0.01 Cklf NM_080775 -0.1 6.24E-03 Ckm CK842589 0.1 0.04 Clcc1 BC070963 0.06 0.03 Clcf1 ENSRNOT00000030569 0.04 0.03 Clcn2 NM_182738 0.15 0.02 Cldnd1 ENSRNOT00000026139 0.11 0.01 Clec11a NM_053980 -0.08 5.33E-03 Page 135 of 288 Diabetes

Clic2 ENSRNOT00000001337 -0.07 0.03 Clic4 NM_001015010 0.12 7.54E-03 Clip1 ENSRNOT00000000749 0.04 0.03 Cln8 ENSRNOT00000000078 -0.07 1.54E-04 Clp1 BQ208856 0.2 1.14E-03 Clpp NM_012529 0.09 0.01 Clptm1l NM_012530 0.07 0.01 Clstn1 NM_133414 0.12 1.78E-04 Clta NM_207615 0.11 0.04 Cml1 BF286024 -0.1 0.03 Cmtm4 ENSRNOT00000056366 -0.1 0.01 Cmtm6 ENSRNOT00000001210 0.1 0.01 Cmtm7 NM_001006955 0.08 0.03 Cnnm3 ENSRNOT00000017857 -0.06 0.02 Cno XM_001075770 -0.09 1.59E-03 Cnot6 NM_017116 -0.12 4.49E-03 Cntfr XM_001073849 -0.12 1.51E-04 Cntn1 ENSRNOT00000029572 -0.07 0.04 Cntnap4 CK471148 0.08 0.02 Col4a3bp AI113128 -0.12 6.65E-05 Commd5 DY319638 0.15 0.03 Commd8 NM_001009599 0.1 1.28E-05 Commd9 XM_217313 0.05 9.60E-03 Comtd1 ENSRNOT00000023211 0.09 1.23E-06 Copb2 ENSRNOT00000045063 0.09 0.02 Cope NM_031974 0.05 0.04 Cops7b XM_001076838 0.08 0.02 Cops8 NM_001011942 0.14 0.04 Coq3 ENSRNOT00000015337 0.08 0.04 Coq5 ENSRNOT00000018116 0.14 0.01 Coq6 NM_139108 0.04 0.04 Coro1a XM_001069497 0.23 3.09E-12 Cox19 NM_001033692 0.07 1.63E-03 Cox5b ENSRNOT00000018897 0.09 0.04 Cpb2 ENSRNOT00000008946 -0.07 0.05 Cpd NM_021765 0.08 4.02E-04 Cplx1 XM_001068587 0.07 2.12E-04 Cplx2 XM_214370 -0.12 1.63E-03 Cpne3 NM_001005889 -0.1 0.01 Cpne5 NM_134462 -0.07 6.31E-04 Cpne8 NM_001024891 -0.1 0.04 Cpox NM_001009470 0.09 0.03 Cpsf5 NM_206950 -0.08 4.08E-03 Cpsf6 NM_153297 0.12 1.88E-03 Cpxm2 XM_343614 0.06 0.02 Crb3 NM_001013227 0.08 1.57E-04 Crcp NM_019187 0.13 1.13E-05 Diabetes Page 136 of 288

Creb1 NM_001011983 0.06 0.05 Creb3 NM_130411 0.11 1.99E-05 Creb3l2 ENSRNOT00000001735 0.07 0.01 Crhr1 NM_017038 -0.08 0.03 Crip3 NM_053586 0.05 0.01 Crop NM_012836 0.13 0.04 Crot NM_022864 0.17 8.71E-12 Cryba2 NM_152935 -0.05 0.05 Crym NM_001037095 0.28 2.15E-21 Cryzl1 CK842415 0.1 1.03E-04 Csda XM_001054321 0.08 0.02 Cse1l NM_001047857 0.05 0.02 Csf1 NM_001025661 0.11 6.36E-07 Csnk1d NM_001017378 -0.1 1.99E-03 Csrp1 NM_001037769 -0.12 3.63E-12 Ctage5 NM_031017 0.09 0.01 Ctbp1 NM_001047880 -0.08 0.01 Ctdspl2 NM_001014048 -0.15 0.04 Ctnnbip1 NM_001013092 0.06 9.31E-03 Ctsb NM_001012188 0.14 0.02 Cttnbp2nl NM_001024867 -0.09 9.19E-03 Cugbp2 NM_172074 -0.05 0.04 Cul1 ENSRNOT00000004394 0.3 2.63E-09 Cul3 ENSRNOT00000025286 0.09 0.02 Cul4b NM_001005535 -0.09 5.12E-03 Cwc15 BP482843 0.06 0.02 Cxcl11 BQ203943 -0.12 6.09E-03 Cyb561d1 NM_031987 0.12 3.37E-03 Cyb5r1 NM_053955 0.21 4.87E-04 Cyc1 BI275231 0.09 1.26E-03 Cycs NM_031979 0.05 4.08E-03 Cyfip1 NM_023981 0.14 0.04 Cyp2f4 NM_001004224 -0.09 3.08E-07 Daam1 ENSRNOT00000005927 -0.18 2.84E-07 Dact1 NM_031127 -0.06 1.83E-04 Dad1 NM_012838 0.06 0.03 Dag1 NM_022286 0.1 8.70E-04 Daglb ENSRNOT00000006995 0.09 3.91E-04 Dap3 ENSRNOT00000055562 0.12 1.54E-03 Dazap2 NM_001013107 -0.57 0 Dbc1 XM_001069456 0.05 0.04 Dbf4 ENSRNOT00000021528 0.1 2.60E-04 Dbt NM_001024987 0.07 1.19E-04 Dcbld1 ENSRNOT00000040396 0.24 3.50E-04 Dclk1 NM_019172 -0.11 1.13E-04 Dclre1a BF406285 -0.07 0.02 Dctd NM_001007720 -0.06 0.04 Page 137 of 288 Diabetes

Dctn2 ENSRNOT00000058116 0.11 0.02 Dd25 NM_001013126 0.07 0.05 Ddi1 NM_001008303 -0.06 5.96E-04 Ddit4 ENSRNOT00000017067 0.08 1.20E-04 Ddr1 NM_012839 0.06 0.01 Ddt ENSRNOT00000016376 0.06 5.95E-03 Ddx19 NM_138910 0.05 0.01 Ddx31 NM_001007689 0.07 0.01 Ddx46 NM_001009640 0.13 1.67E-09 Ddx47 NM_001011950 0.09 5.11E-04 Ddx54 NM_080482 0.06 0.02 Ddx56 ENSRNOT00000011351 0.07 0.03 Dedd NM_001031650 -0.05 0.01 Degs1 BC093403 -0.1 7.81E-03 Dek XM_238038 -0.1 8.69E-04 Depdc1a ENSRNOT00000020267 0.23 3.90E-10 Dffa NM_017137 0.23 8.85E-04 Dgat1 ENSRNOT00000000462 0.19 1.78E-03 Dgcr8 NM_001007627 -0.07 0.02 Dguok ENSRNOT00000003804 -0.09 7.07E-03 Dhcr24 NM_031008 -0.06 0.05 Dhrs1 NM_199403 0.15 0.01 Dhtkd1 NM_080906 0.24 9.85E-15 Dhx33 BQ200228 0.09 0.01 Dhx37 NM_001007616 0.06 0.01 Dhx8 NM_024131 0.13 0.01 Dicer1 ENSRNOT00000017683 0.13 6.21E-03 Dido1 NM_053487 -0.07 9.81E-03 Dis3 NM_001005381 0.05 5.21E-03 Dlat BQ205841 0.14 8.36E-04 Dld NM_001015005 0.04 0.02 Dlg3 NM_053525 0.13 1.74E-05 Dnaic1 ENSRNOT00000014926 -0.09 0.01 Dnaja1 NM_001025413 -0.06 0.03 Dnaja2 XM_001054550 -0.12 2.47E-03 Dnaja4 ENSRNOT00000006747 0.11 1.39E-08 Dnajb1 ENSRNOT00000001859 0.1 0.03 Dnajb14 NM_181087 -0.06 0.03 Dnajc10 ENSRNOT00000004939 -0.07 1.18E-03 Dnajc12 NM_001004211 0.09 3.02E-03 Dnajc15 XM_001080406 0.11 6.99E-04 Dnajc16 NM_053679 0.16 1.06E-03 Dnajc3 NM_053437 0.1 0.02 Dnase1l1 NM_001025720 0.22 3.50E-05 Dner ENSRNOT00000009468 0.14 0.01 Dnm1l NM_001047844 0.07 0.02 Dnmt1 NM_001015014 -0.11 5.00E-03 Diabetes Page 138 of 288

Dock8 ENSRNOT00000057432 -0.11 1.81E-04 Dock9 NM_017243 -0.1 8.14E-04 Dohh ENSRNOT00000014405 0.11 2.20E-04 Dok1 ENSRNOT00000037588 0.11 0.01 Dolk XM_001077211 0.26 4.64E-03 Dolpp1 702385582H1 0.06 0.03 Dpf2 NM_198777 -0.05 0.04 Dph4 NM_199385 0.09 2.23E-03 Dpm1 NM_001039022 0.1 6.64E-04 Dpm2 BF398994 0.08 0.01 Dpp6 NM_001034104 -0.07 0.02 Dpysl3 NM_022701 -0.1 0.03 Dqx1 ENSRNOT00000051669 -0.07 7.42E-03 Drap1 CB718513 0.1 3.70E-04 Drd3 NM_001034032 0.07 0.02 Dsc1 NM_001011949 -0.06 7.45E-03 Dscr6 ENSRNOT00000012530 0.11 1.95E-03 Dusp11 703906822J1 -0.07 0.05 Dusp12 CB768306 -0.1 0.03 Dusp2 NM_001014194 0.11 2.49E-04 Dusp27 NM_022232 0.09 3.51E-03 Dync1i1 NM_001014223 0.11 0.02 Dync2li1 XM_216362 0.13 5.59E-04 Dynll2 CB322978 -0.15 4.40E-03 Dynlt1 ENSRNOT00000022564 0.21 5.39E-09 Dynlt3 ENSRNOT00000002478 0.1 4.69E-03 Dyrk3 NM_001025006 0.09 9.74E-03 Dyt1 NM_001009480 0.04 0.02 E2f5 NM_001024908 -0.08 4.52E-03 E2f6 BF397860 0.06 0.03 Ebag9 NM_001025416 0.09 0.05 Ebna1bp2 ENSRNOT00000022786 0.1 5.33E-03 Ebp ENSRNOT00000024385 0.07 8.35E-03 Ece2 NM_199388 0.05 8.78E-03 Ecsit XM_342483 0.22 9.24E-06 Edem2 AI237779 -0.1 0.04 Eed ENSRNOT00000016150 0.1 5.94E-04 Eef1a1 BM392332 -0.11 4.25E-03 Eef1d NM_019252 0.07 1.44E-03 Eefsec NM_001077668 0.05 0.03 Eepd1 NM_173330 -0.11 8.60E-04 Efcab7 ENSRNOT00000002392 0.06 0.01 Efhd1 NM_017140 0.11 7.57E-03 Efhd2 ENSRNOT00000002289 0.13 3.11E-04 Efna3 ENSRNOT00000002864 -0.1 6.66E-03 Efnb3 XM_578496 -0.11 1.03E-06 Eftud1 NM_001012089 0.08 0.02 Page 139 of 288 Diabetes

Ehhadh CK839791 -0.07 0.01 Ehmt1 CK842001 0.09 0.02 Ehmt2 NM_001014188 -0.11 3.59E-08 Eid1 NM_153303 -0.05 9.89E-03 Eif1 NM_031325 0.09 2.76E-03 Eif1ad NM_022597 0.08 0.02 Eif1ay NM_019234 0.16 1.64E-03 Eif2ak1 NM_031318 0.05 8.74E-03 Eif2b1 NM_001013228 0.08 0.03 Eif2b2 NM_001024767 0.09 4.33E-03 Eif2b4 AI556959 0.17 6.15E-03 Eif2b5 704308553J1 0.12 1.05E-03 Eif2c1 NM_001009652 0.08 0.04 Eif2c4 NM_138875 -0.12 4.34E-04 Eif2s3x ENSRNOT00000046563 -0.05 0.01 Eif3f NM_001012036 0.05 0.04 Eif3g NM_001008721 0.08 1.14E-03 Eif3s9 NM_057137 0.07 4.87E-03 Eif4a1 AI229953 0.09 0.02 Eif4a2 NM_001008335 -0.07 8.67E-03 Eif4e2 ENSRNOT00000001437 0.11 7.75E-03 Eif4ebp2 NM_001012347 -0.1 9.92E-03 Eif4h NM_001006986 0.06 0.05 Eif5 ENSRNOT00000024082 0.08 0.02 Eif6 NM_001013104 0.04 0.05 Ela3b ENSRNOT00000017323 0.06 5.01E-03 Elavl1 ENSRNOT00000021168 0.2 1.98E-04 Elavl2 NM_133417 -0.06 7.78E-03 Elk4 ENSRNOT00000004353 -0.09 0.04 Elovl4 NM_001031648 0.11 0.02 Emilin1 704254958J1 -0.09 5.82E-03 Eml4 XM_001053827 -0.09 0.02 Eml5 NM_133596 -0.1 1.37E-03 Enc1 BF522735 -0.1 0.02 Enoph1 XM_218845 0.11 2.54E-03 Enpp5 704204205H1 0.07 0.04 Entpd3 XM_001077166 0.05 7.77E-03 Entpd6 NM_001025660 0.07 5.81E-03 Ep300 ENSRNOT00000000206 -0.1 0.04 Epb4.1l3 NM_001008305 0.23 3.17E-07 Epdr1 CA505998 0.1 1.49E-04 Epha7 NM_013223 0.04 0.04 Ephb3 NM_172029 0.11 1.32E-05 Epn2 ENSRNOT00000055330 -0.11 2.64E-03 Eps8 XM_001065057 -0.11 5.92E-03 Ercc8 NM_032058 0.06 0.05 Erich1 NM_053950 0.07 6.59E-03 Diabetes Page 140 of 288

Ero1l BE109072 0.31 1.87E-03 Ero1lb NM_012661 -0.09 0.05 Esd NM_001013095 0.05 9.35E-03 Espn NM_001014150 0.07 0.01 Espnl NM_001031640 0.09 0.02 Etfb NM_199372 0.05 0.03 Etnk1 NM_001008340 -0.11 0.02 Etv1 ENSRNOT00000023408 -0.11 0.01 Etv6 NM_001006957 0.06 1.14E-03 Exo1 NM_001037352 0.1 5.76E-04 Exosc5 ENSRNOT00000036788 0.08 4.56E-04 Ext1 NM_001007621 0.11 8.67E-08 Extl3 NM_001012064 -0.11 9.41E-03 Eya3 ENSRNOT00000001415 0.05 0.01 Ezh2 XM_001062735 0.17 2.85E-07 F11r NM_001024998 -0.12 7.27E-10 F3 ENSRNOT00000009428 -0.12 0.01 Fabp5 NM_001009391 0.05 0.03 Fadd NM_001012744 0.2 0.05 Fads1 ENSRNOT00000005939 -0.07 9.95E-03 Fads2 NM_013080 -0.09 0.05 Fah NM_178106 0.1 4.50E-03 Fahd2a NM_001006987 -0.06 0.04 Fam100b ENSRNOT00000035651 -0.1 1.40E-03 Fam101b NM_053498 0.13 0.01 Fam105a NM_001007708 -0.09 0.02 Fam107b NM_001024333 -0.12 5.82E-03 Fam108c1 ENSRNOT00000022878 0.1 0.02 Fam116a NM_001007667 -0.06 0.05 Fam120b NM_001007625 0.05 2.36E-03 Fam122a NM_134331 0.07 0.04 Fam124a ENSRNOT00000044896 0.14 1.53E-05 Fam134c ENSRNOT00000013598 0.08 2.64E-04 Fam148c NM_001014136 -0.12 2.46E-07 Fam152b XM_001075018 0.07 0.02 Fam19a5 BC071175 0.2 1.06E-15 Fam20b NM_130749 -0.07 3.06E-03 Fam43a ENSRNOT00000013324 0.06 6.80E-03 Fam54b XM_237393 0.08 0.04 Fam69a NM_001037353 0.12 0.02 Fam78a NM_001000176 -0.08 0.05 Fam81a NM_001014181 -0.1 5.98E-05 Fam82c ENSRNOT00000028026 0.09 0.02 Fam83d ENSRNOT00000037809 0.19 1.10E-03 Fam98a 703957179J1 0.1 2.97E-03 Fanca ENSRNOT00000008149 0.07 0.02 Fancc NM_145878 0.1 0.02 Page 141 of 288 Diabetes

Fancl ENSRNOT00000028302 0.08 0.02 Farsa NM_017181 0.08 1.44E-03 Farsb NM_001007611 0.25 1.47E-03 Fbl ENSRNOT00000014585 -0.05 0.02 Fbp2 ENSRNOT00000017362 0.07 2.45E-03 Fbxl5 ENSRNOT00000003085 -0.07 1.34E-03 Fbxl6 NM_001000013 -0.09 0.01 Fbxo22 NM_001008764 -0.08 1.13E-06 Fbxo25 CB328346 0.07 0.02 Fbxo34 NM_001014029 0.05 0.04 Fbxo4 NM_001025626 -0.11 1.87E-03 Fbxo46 ENSRNOT00000012990 0.08 7.38E-03 Fbxo9 ENSRNOT00000027217 0.11 0.04 Fbxw2 BE112735 0.08 4.55E-03 Fer1l4 BQ782870 0.14 0.04 Fetub S78734 0.06 6.06E-04 Fez1 NM_133563 -0.07 1.80E-03 Ffar1 ENSRNOT00000007379 -0.12 9.14E-03 Fgf13 NM_001039002 0.05 4.66E-03 Fgfr1op2 ENSRNOT00000013845 0.18 2.25E-10 Fgl2 ENSRNOT00000007447 -0.12 3.48E-03 Fibin NM_001013935 0.09 8.61E-05 Filip1 NM_001005556 0.1 0.02 Fis1 ENSRNOT00000033837 -0.07 0.02 Fkbp1b NM_001025412 0.11 1.59E-03 Fkbp2 ENSRNOT00000028725 -0.22 1.35E-19 Fkbp8 ENSRNOT00000031261 -0.08 0.04 Fkrp ENSRNOT00000030479 0.11 3.40E-03 Fktn ENSRNOT00000023729 0.08 0.02 Flot1 NM_001008557 0.05 0.04 Flrt3 BF393700 -0.1 0.03 Fmo5 NM_078623 -0.06 0.02 Fnbp1l NM_032067 -0.11 0.01 Fndc3a ENSRNOT00000001717 0.06 6.07E-03 Foxd4 BQ780977 -0.1 5.24E-03 Foxo3a ENSRNOT00000000327 -0.17 7.43E-08 Foxp2 g8512175 -0.18 0.03 Frap1 NM_001014046 0.13 0.02 Frmd3 NM_001014073 0.1 3.05E-05 Frmd6 ENSRNOT00000022658 0.07 0.04 Frrs1 NM_012557 0.08 2.63E-05 Fstl4 NM_001013070 -0.1 0.02 Ftsj3 NM_001024237 0.08 0.03 Fut9 NM_001004252 0.06 0.02 Fxc1 NM_053716 0.25 8.17E-05 Fxr1 NM_001014239 0.05 0.03 Fxyd4 XM_001073518 0.07 0.04 Diabetes Page 142 of 288

Fzd5 NM_001025642 0.07 0.02 Fzd9 NM_001011998 0.06 0.03 G0s2 NM_012755 -0.12 0.02 Gabrd ENSRNOT00000025399 0.07 6.54E-03 Gad1 NM_019271 -0.12 6.36E-05 Gadd45a XM_001062752 -0.06 8.04E-03 Gadd45gip1 XM_230795 0.15 3.99E-07 Gak NM_053428 0.2 4.33E-04 Gale NM_201421 0.08 0.03 Galk2 ENSRNOT00000007077 0.12 6.09E-03 Galnt13 AW523517 0.08 0.03 Galnt14 NM_022675 0.06 0.04 Galnt7 U19516 0.1 3.35E-05 Galr2 ENSRNOT00000045014 -0.05 0.02 Gap43 NM_001025678 0.14 1.97E-03 Gars DV724695 0.1 1.23E-03 Gas7 NM_001033065 -0.1 6.21E-03 Gata4 ENSRNOT00000001923 -0.09 0.03 Gatad1 XM_343616 0.11 2.50E-05 Gatc NM_020075 0.06 3.72E-03 Gatm NM_012847 0.05 0.02 Gba2 NM_019906 0.09 0.02 Gcat ENSRNOT00000008654 0.1 0.02 Gcdh ENSRNOT00000009610 0.11 0.04 Gcgr BQ781686 -0.1 1.87E-04 Gclc XM_001073918 0.12 1.32E-06 Gcnt3 CB328208 -0.08 5.55E-03 Gdap1l1 NM_199407 0.11 0.01 Gde1 NM_001012014 0.1 0.01 Gdf2 NM_053465 0.2 2.20E-03 Gdi2 NM_053371 0.06 0.03 Gdpd1 BC099129 0.18 5.35E-04 Gem NM_022388 0.1 9.47E-03 Gemin4 NM_153305 0.25 0.01 Gemin6 NM_017289 0.08 4.53E-04 Gemin7 ENSRNOT00000004027 0.07 0.03 Gfm2 ENSRNOT00000023414 -0.08 0.03 Ggta1 NM_031030 0.08 5.90E-03 Ghitm NM_080783 0.06 0.03 Git2 ENSRNOT00000029411 -0.09 2.32E-04 Glce NM_001004220 0.04 0.01 Glipr2 NM_001013919 0.07 4.25E-03 Glrx5 NM_001012109 0.17 4.08E-10 Gls ENSRNOT00000005314 0.07 8.07E-03 Glt25d1 BF397407 0.23 1.57E-06 Glt8d3 NM_001013130 -0.07 0.05 Gltp NM_017195 0.11 1.92E-08 Page 143 of 288 Diabetes

Gltpd1 ENSRNOT00000014780 0.06 4.75E-03 Glul NM_131911 -0.05 6.86E-03 Gm2a BF418861 0.09 0.03 Gmcl1 ENSRNOT00000001536 0.07 0.03 Gmfg NM_031031 0.2 1.79E-15 Gmpr2 NM_053876 -0.09 7.15E-07 Gna12 NM_001009697 -0.05 0.04 Gna14 ENSRNOT00000022002 0.15 1.03E-07 Gnai1 CK226550 0.09 7.18E-04 Gnb1 NM_001033663 -0.11 8.82E-03 Gnb5 ENSRNOT00000049170 -0.07 8.85E-03 Gng10 NM_001024277 0.18 1.13E-03 Gng3 ENSRNOT00000028363 -0.11 3.45E-03 Gnpnat1 ENSRNOT00000004570 0.05 9.12E-03 Gnptab NM_012815 0.2 2.04E-04 Golga5 NM_001025640 0.04 0.04 Golim4 NM_017305 0.13 4.77E-04 Golt1a NM_032615 0.08 1.15E-04 Got1 XM_225059 0.07 0.04 Gpbp1 NM_017276 0.04 0.03 Gpd1 BG664800 0.09 0.04 Gpld1 NM_001044238 0.14 1.06E-04 Gpm6b XM_232788 0.08 1.24E-04 Gpr112l ENSRNOT00000058752 -0.09 0.02 Gpr119 XM_001080744 0.09 0.05 Gpr128 NM_001009466 0.13 3.47E-05 Gpr149 ENSRNOT00000040934 0.08 1.85E-03 Gpr180 NM_012959 0.09 2.67E-03 Gpr50 NM_145674 0.13 0.04 Gpr6 CO567719 0.11 0.02 Gpr85 NM_001005908 0.06 3.01E-03 Gpr89 ENSRNOT00000021308 0.11 4.76E-04 Gprasp1 NM_021669 0.08 0.01 Gprasp2 ENSRNOT00000038641 0.09 0.01 Gprc5b XM_223701 0.09 0.03 Gpsm1 NM_031692 0.1 3.75E-04 Gpsm2 ENSRNOT00000019916 0.06 0.03 Gramd3 ENSRNOT00000005781 0.07 2.81E-03 Grb14 CB324591 0.26 1.85E-04 Grhpr CK365279 0.08 0.03 Gria2 CO568507 0.07 5.77E-03 Gria3 NM_001011711 -0.09 0.03 Grm2 ENSRNOT00000010380 -0.11 0.01 Grpel1 NM_001007703 0.06 0.03 Gsbs NM_001033699 -0.08 7.20E-05 Gsk3b ENSRNOT00000046475 -0.08 0.02 Gspt2 NM_001033931 0.12 2.60E-04 Diabetes Page 144 of 288

Gstm3 NM_181091 0.08 0.01 Gsto1 NM_053348 0.07 0.05 Gtdc1 NM_001024274 -0.1 0.05 Gtf2b NM_001013151 0.23 6.97E-05 Gtf2e1 703824281J1 0.08 0.03 Gtf2f1 DV713743 0.12 7.69E-06 Gtf2f2 NM_053660 0.07 2.91E-04 Gtf2h5 NM_001008301 -0.07 7.73E-04 Gtf2i NM_001034911 0.15 1.94E-11 Gtf2ird1 XM_001059083 -0.06 0.01 Gtf3c2 XM_573746 0.09 0.04 Gtf3c3 703948844J1 0.08 2.08E-03 Gtf3c4 ENSRNOT00000006946 0.09 4.75E-03 Gtf3c6 ENSRNOT00000037115 0.11 0.02 Gtse1 ENSRNOT00000003918 0.08 0.02 Gucy1b3 NM_012571 0.05 0.01 Gucy2c ENSRNOT00000036658 0.08 0.01 Gusb NM_031630 -0.08 0.02 Gyltl1b ENSRNOT00000024196 0.1 8.13E-05 H1f0 NM_001007618 -0.07 4.60E-04 H2afx NM_138846 0.16 3.84E-05 H2afy NM_203338 0.09 7.99E-06 Habp4 ENSRNOT00000037742 0.1 0.01 Hand2 XM_001059246 0.29 0.02 Hbegf NM_012945 -0.32 8.24E-05 Hbp1 NM_001008859 -0.1 3.81E-03 Hdac5 NM_001014061 -0.11 2.32E-04 Hddc3 NM_138891 0.14 3.35E-03 Hdhd3 NM_001006994 0.12 3.82E-06 Hdlbp ENSRNOT00000015147 0.14 4.63E-03 Heatr3 g11402451 0.12 3.03E-03 Heatr5b XM_343418 -0.12 1.69E-04 Hel308 BE121245 0.13 1.47E-03 Hexb NM_013155 0.2 1.24E-04 Hibadh ENSRNOT00000059801 -0.11 0.05 Hic1 NM_134386 0.05 0.04 Hip1 NM_173838 0.13 6.58E-05 Hip2 ENSRNOT00000004260 0.08 2.04E-03 Hist1h1b ENSRNOT00000021441 0.17 3.62E-05 Hist1h4b ENSRNOT00000016250 0.08 7.26E-03 Hivep2 ENSRNOT00000020829 -0.1 0.02 Hmg20a BI281497 0.16 1.75E-04 Hmgb2l1 ENSRNOT00000018692 -0.27 1.07E-04 Hmgb3 ENSRNOT00000050774 -0.11 9.09E-03 Hmgcl ENSRNOT00000051445 0.07 2.54E-03 Hmgcr ENSRNOT00000039610 0.19 0.03 Hmgcs1 NM_013022 -0.08 0.03 Page 145 of 288 Diabetes

Hn1l NM_024487 0.05 0.02 Hnrnpa1 ENSRNOT00000055702 -0.05 0.05 Hnrnpu NM_057139 -0.18 2.15E-05 Homez NM_001012068 -0.08 0.02 Hook1 ENSRNOT00000019410 -0.1 0.01 Hoxa10 XM_001057027 0.17 1.27E-06 Hpdl CK228213 0.11 2.00E-03 Hpse NM_031041 0.06 0.03 Hrk ENSRNOT00000016804 0.08 3.18E-03 Hs1bp3 ENSRNOT00000042864 0.09 1.74E-04 Hsd17b10 NM_001007711 0.12 1.29E-06 Hsd17b12 NM_031042 0.07 0.04 Hsdl2 ENSRNOT00000028440 -0.11 0.03 Hspa4 NM_001025120 0.08 0.01 Hspa4l NM_001014232 -0.08 1.04E-04 Hspa9 CB583374 0.1 4.99E-03 Hsph1 ENSRNOT00000000716 0.05 0.03 Htatip2 ENSRNOT00000022012 0.12 7.70E-03 Htr5b NM_012769 0.1 2.99E-05 Hus1 NM_013170 0.18 8.42E-09 Hypk NM_199107 0.1 3.18E-04 Id1 ENSRNOT00000059715 0.06 0.02 Id3 NM_001079940 0.23 1.11E-25 Idh3a NM_022696 0.06 0.04 Idi1 ENSRNOT00000019184 -0.09 0.01 Ifi30 NM_001033909 -0.07 0.01 Ifi35 NM_024140 -0.05 0.02 Ifi47 ENSRNOT00000002473 -0.1 0.01 Ifitm1 ENSRNOT00000019225 -0.09 2.33E-03 Ifitm6 NM_001025744 -0.08 1.18E-03 Ifngr1 ENSRNOT00000016445 0.06 3.12E-03 Ifngr2 ENSRNOT00000020380 0.07 0.01 Ifrd2 NM_172039 0.09 6.72E-04 Ift20 ENSRNOT00000020793 0.2 2.51E-03 Ift52_predicted BC086609 0.12 2.40E-08 Igfbp1 NM_031800 -0.11 4.10E-06 Igfbp4 702969538T1 0.07 0.02 Igfbp5 ENSRNOT00000030497 0.13 0.03 Ikzf2 BQ205283 0.05 0.01 Il12rb2 ENSRNOT00000024304 0.11 2.64E-03 Il13ra1 CK841271 0.16 0.02 Il15 NM_017248 -0.11 3.65E-03 Il17rb ENSRNOT00000009528 -0.11 4.04E-03 Il20ra NM_144745 -0.1 0.01 Il33 ENSRNOT00000022976 0.24 0.01 Ilk NM_022402 -0.05 1.63E-03 Incenp NM_024386 0.09 3.48E-03 Diabetes Page 146 of 288

Ing4 XM_340879 -0.09 1.80E-05 Ing5 NM_013134 0.05 0.04 Inpp4a NM_080904 -0.09 4.29E-03 Inpp5f NM_001047907 -0.05 0.03 Insig2 CB324023 -0.07 0.01 Insr NM_001013182 0.05 0.04 Insrr NM_053309 0.22 2.52E-03 Ints9 ENSRNOT00000036394 0.12 1.74E-04 Ippk NM_001024756 0.06 0.02 Iqgap1 ENSRNOT00000031852 -0.11 1.45E-04 Ireb2 ENSRNOT00000006680 -0.08 9.19E-03 Irf1 XM_001081593 -0.09 0.02 Isg20 ENSRNOT00000001979 -0.07 2.69E-03 Isg20l1 NM_001014068 0.11 0.03 Isl1 NM_017339 -0.1 0.01 Isoc1 NM_138840 -0.1 0.01 Isy1 AI548634 -0.05 2.31E-03 Itch NM_001005887 -0.2 1.91E-03 Itga6 NM_172335 0.07 0.01 Itln1 NM_199108 -0.07 0.01 Itm2b ENSRNOT00000041915 -0.07 0.03 Itpk1 NM_139336 0.18 5.95E-13 Itpr1 BI296732 -0.09 4.93E-06 Ivd 703884374J1 0.12 0.03 Iws1 NM_031682 0.06 0.01 Jag2 NM_133390 -0.08 9.33E-03 Jak1 NM_032066 0.1 5.00E-04 Jakmip1 ENSRNOT00000037360 -0.08 4.81E-03 Jarid1b EV778094 -0.18 1.49E-03 Jazf1 BQ200546 0.08 6.52E-04 Josd2 NM_001025059 -0.1 0.05 Jund NM_175603 -0.07 5.90E-04 Kars ENSRNOT00000026696 0.08 1.41E-03 Katna1 NM_001011901 0.07 7.41E-03 Kbtbd4 ENSRNOT00000036258 0.08 2.45E-05 Kcna4 ENSRNOT00000003441 0.16 8.26E-12 Kcnab3 NM_012578 -0.12 3.53E-04 Kcnc1 ENSRNOT00000027963 -0.12 2.09E-03 Kcnd2 NM_053585 -0.07 0.04 Kcne2 ENSRNOT00000004896 -0.08 5.76E-03 Kcnh1 ENSRNOT00000021091 0.09 6.10E-03 Kcnip3 NM_012797 0.36 3.07E-05 Kcnj11 BC100646 -0.1 0.01 Kcnj12 NM_053981 -0.12 2.44E-03 Kcnj5 NM_013058 0.24 3.08E-03 Kcnk1 NM_001014161 0.09 6.27E-04 Kcnk6 703915184J1 0.07 0.01 Page 147 of 288 Diabetes

Kcnmb2 NM_001007686 -0.12 3.20E-04 Kcnmb4 ENSRNOT00000038888 0.12 1.38E-07 Kcnq5 NM_053783 0.07 3.43E-03 Kctd13 ENSRNOT00000018717 0.11 0.01 Kctd19 AI598699 0.11 7.71E-03 Kctd2 NM_001034136 -0.05 0.04 Kctd6 ENSRNOT00000046314 -0.1 0.05 Kctd9 NM_181770 0.18 0.02 Kdelr2 NM_001047871 0.07 0.04 Ke2 ENSRNOT00000011795 0.06 5.22E-03 Keap1 XM_001069325 0.07 0.01 Khdrbs2 NM_133398 -0.09 0.03 Kif1b NM_001004274 0.09 8.12E-04 Kif21a ENSRNOT00000017688 -0.07 0.04 Kif22 ENSRNOT00000023530 0.24 1.69E-04 Kit NM_012775 -0.11 0.03 Klb ENSRNOT00000057849 0.19 0.05 Klc1 ENSRNOT00000009883 0.11 0.04 Klc3 NM_001024794 -0.07 0.01 NM_145789 0.15 2.71E-06 Klf6 ENSRNOT00000055607 -0.1 9.19E-05 Klf7 ENSRNOT00000027882 -0.08 1.43E-05 Klf9 NM_203410 -0.06 0.04 Klhdc5 CK839877 0.09 0.03 Klhl20 ENSRNOT00000003851 0.09 0.02 Klhl5 NM_053502 -0.06 1.76E-03 Klhl8 ENSRNOT00000031175 -0.08 0.02 Kpna1 NM_032057 0.11 1.11E-06 Kpna4 NM_031623 0.11 6.65E-04 Kpna6 BF418429 0.17 1.30E-06 Kras NM_001025717 -0.09 0.02 Ktelc1 CB783751 0.06 0.02 Kti12 NM_017071 0.17 3.77E-03 Lactb2 XM_001068054 0.09 6.67E-03 Lamc1 NM_031154 0.07 0.02 Lamc2 CK482214 -0.07 0.01 Lancl2 NM_020101 -0.08 0.01 Lap3 ENSRNOT00000018071 0.13 3.01E-03 Large ENSRNOT00000018434 -0.21 1.66E-15 Larp6 BC092638 0.08 2.73E-03 Lass2 NM_022585 -0.11 1.12E-04 Lats2 ENSRNOT00000026163 -0.11 4.37E-04 Lcmt1 NM_012592 0.12 8.63E-03 Lcp2 NM_019141 -0.08 0.03 Ldhb NM_001034918 0.06 0.03 Leng1 ENSRNOT00000015438 0.06 0.04 Leng9 ENSRNOT00000039580 0.12 0.01 Diabetes Page 148 of 288

Leprot NM_145673 -0.11 5.64E-03 Lfng NM_001004217 0.1 2.17E-03 Lgi2 CA511643 -0.07 4.72E-03 Lhx8_predicted CF110715 -0.06 1.80E-03 Limd2 NM_012892 -0.12 0.01 Lingo4 XM_001079638 -0.08 0.04 Lipa NM_012971 0.11 0.02 Llgl1 CB607322 -0.09 8.60E-03 Lmna NM_031742 0.13 0.03 Lmo1 NM_032462 0.1 4.28E-03 Lmo4 NM_017297 0.09 0.02 Lnp NM_021688 0.1 1.59E-06 Lnx1 ENSRNOT00000021372 -0.08 0.04 LOC679651 NM_030868 -0.1 0.03 LOC679668 NM_053806 0.13 0.02 LOC679811 NM_080887 -0.06 0.02 LOC679880 XM_001075666 0.07 0.05 LOC679931 XM_001068535 0.15 9.47E-05 LOC680039 NM_001013122 0.07 3.99E-03 LOC680117 NM_212506 0.06 0.03 LOC680133 CK844293 0.08 0.02 LOC680308 NM_001009645 0.06 9.69E-03 LOC680477 XM_001078178 0.15 1.45E-03 LOC680531 NM_001081973 0.05 0.02 LOC681086 BC085720 0.2 6.01E-03 LOC681309 XM_001074361 0.15 0.02 LOC685169 NM_198726 0.08 3.87E-03 LOC685203 DY472822 0.11 5.85E-06 LOC685398 ENSRNOT00000013331 -0.09 5.11E-05 LOC685569 ENSRNOT00000006074 -0.07 0.01 LOC685634 NM_001015029 0.15 0.02 LOC685700 ENSRNOT00000051428 0.06 9.02E-03 LOC686117 XM_233544 -0.1 0.03 LOC688393 NM_001044288 0.04 0.02 LOC688558 NM_001024247 0.12 2.73E-07 LOC689176 ENSRNOT00000058160 -0.12 6.61E-03 LOC689226 NM_057205 -0.11 1.17E-05 LOC689574 g11671089 0.18 1.56E-03 LOC689663 BC062409 0.05 0.04 LOC690164 NM_001012099 0.21 3.36E-04 LOC690470 ENSRNOT00000033784 -0.09 1.06E-03 LOC690489 NM_001011910 0.07 4.65E-04 LOC690728 NM_013011 0.05 0.03 LOC691862 ENSRNOT00000017147 0.11 5.99E-03 LOC691903 g18183952 -0.06 0.04 Lpar1 ENSRNOT00000002983 0.09 1.75E-04 Lpin1 CO566009 -0.08 3.76E-03 Page 149 of 288 Diabetes

Lppr4 ENSRNOT00000016042 0.1 2.36E-04 Lrig1 NM_199405 0.06 7.66E-03 Lrp6 NM_012595 0.42 1.79E-09 Lrpap1 ENSRNOT00000017546 0.12 2.95E-08 Lrrc26 NM_053448 -0.09 9.64E-06 Lrrc28 ENSRNOT00000025138 0.12 4.47E-05 Lrrc40 AI236775 0.09 0.02 Lrrc59 ENSRNOT00000006852 0.09 5.01E-03 Lrrc8d g14924219 0.25 5.20E-07 Lrrc8e BC062018 0.13 0.02 Lrrfip1 BI276990 0.13 0.02 Lrrn3 NM_139112 0.14 0.05 Lrrtm3 NM_001009708 0.08 3.73E-03 Lsm1 704152653J1 0.14 7.67E-04 Lsm11 ENSRNOT00000007267 -0.07 0.04 Lsm3 ENSRNOT00000007993 0.1 0.05 Lsm7 XM_001056792 0.11 0.04 Lsm8 ENSRNOT00000024211 -0.12 9.24E-04 Luc7l XM_001054238 0.07 0.04 Luc7l2 ENSRNOT00000056774 -0.09 1.87E-03 Luzp5 ENSRNOT00000011029 0.07 0.01 Lypd1 ENSRNOT00000018640 0.08 4.93E-03 Lypla2 ENSRNOT00000014603 0.07 2.57E-03 Lypla3 ENSRNOT00000020576 0.1 0.03 Mad2l1 ENSRNOT00000017466 0.12 2.62E-03 Mad2l1bp XM_001060262 0.11 5.43E-07 Mad2l2 ENSRNOT00000008660 0.14 0.01 Maea BE102310 0.16 0.04 Maf1 NM_173311 -0.08 0.01 Maged2 ENSRNOT00000019224 0.1 8.65E-03 Magee2 ENSRNOT00000048127 0.12 0.02 Magi2 NM_012634 -0.1 2.57E-03 Maml3 CR466784 -0.07 0.02 Man2a1 ENSRNOT00000047859 0.08 3.89E-03 Map1lc3b XM_001068230 0.07 5.54E-03 Map2k1ip1 ENSRNOT00000008839 0.07 0.03 Map2k4 XM_001064302 0.18 7.11E-03 Map2k5 CK841336 0.11 2.72E-05 Map3k4 ENSRNOT00000023989 -0.11 1.06E-04 Map3k7ip1 ENSRNOT00000023515 -0.05 0.05 Map4k3 XM_001059465 0.39 2.47E-10 Map4k5 XM_001080848 0.26 3.30E-16 Mapkap1 AF014418 0.21 1.33E-06 Mapkapk2 XM_001058884 -0.12 0.02 Mapt BG373322 -0.21 9.40E-05 Matn2 704235724H1 0.13 0.03 Max NM_001006967 0.05 0.02 Diabetes Page 150 of 288

Mbd1 BC086552 -0.07 7.66E-03 Mbd4 ENSRNOT00000041515 -0.11 0.05 Mboat2 ENSRNOT00000012876 0.06 1.20E-03 Mcart1 NM_133609 -0.09 1.97E-05 Mccc1 NM_001001508 0.12 2.21E-09 Mccc2 ENSRNOT00000051989 0.08 0.04 Mcf2l BF287838 -0.09 5.62E-03 Mcfd2 ENSRNOT00000017384 0.1 0.03 Mcm5 ENSRNOT00000008486 0.07 0.04 Mcts2 ENSRNOT00000033858 0.2 1.83E-05 Mdm2_predicted BE103175 0.07 0.02 Mdn1 NM_001034926 0.08 9.29E-04 Mdp1 NM_001037179 0.05 0.02 Me3 NM_001008338 0.06 0.02 Mea1 AI231764 0.1 0.02 Med1 XM_001057978 -0.06 0.01 Med17 NM_001034139 0.14 6.37E-04 Med19 XM_001075566 -0.09 0.03 Med21 NM_030856 0.09 0.04 Med27 NM_012782 -0.07 0.03 Med30 ENSRNOT00000033980 0.08 0.04 Med4 ENSRNOT00000011557 0.1 1.91E-04 Med6 XM_001059585 0.08 2.36E-04 Med8 CF976160 -0.06 0.01 Melk g8493745 -0.12 0.01 Mettl10 ENSRNOT00000026551 0.05 0.03 Mettl4 CF978325 0.05 0.03 Mex3a ENSRNOT00000052079 -0.24 2.11E-03 Mfn2 ENSRNOT00000035255 0.12 4.53E-03 Mfsd1 AF000300 0.09 7.40E-03 Mfsd2 NM_001007727 0.2 1.50E-11 Mgat2 NM_031342 0.06 0.05 Mgat4a NM_001004277 0.09 6.46E-03 Mgat5 ENSRNOT00000007285 0.06 0.03 Mgea5 AF441118 -0.07 0.02 Mgst1 NM_001009699 0.15 4.53E-20 Mib1 ENSRNOT00000002432 -0.05 0.02 Mid2 NM_001012106 0.12 1.26E-05 Mier3 NM_001008319 0.06 2.57E-04 Mif4gd NM_012980 -0.1 0.04 Mkln1 NM_080479 0.07 0.03 Mknk2 CK844472 -0.11 0.04 Mlc1 ENSRNOT00000037575 0.09 0.04 Mllt3 NM_001012078 -0.1 2.20E-03 Mlxipl NM_001008694 -0.07 0.01 Mme g4136169 0.21 6.24E-05 Mmp11 NM_001013940 -0.04 0.03 Page 151 of 288 Diabetes

Mmp21 ENSRNOT00000019497 -0.06 2.21E-03 Mmp28 NM_022867 0.05 0.03 Moap1 ENSRNOT00000007189 0.15 0.04 Mobkl3 AI411936 0.13 9.48E-03 Mon2 702961974J1 0.13 1.57E-07 Moxd1 XM_232260 -0.12 1.57E-03 Mphosph9 XM_001055154 0.08 0.01 Mpp6 704155893J1 0.1 0.05 Mrpl12 NM_001011964 0.12 9.45E-03 Mrpl13 703890108J1 0.1 1.19E-03 Mrpl15 ENSRNOT00000008361 0.11 4.52E-03 Mrpl16 BC099778 0.1 1.93E-04 Mrpl17 NM_001009653 0.06 0.04 Mrpl35 NM_001012177 0.13 0.01 Mrpl36 CO382904 0.1 2.07E-06 Mrpl44 NM_001008861 0.06 0.03 Mrpl46 NM_139253 0.11 4.65E-08 Mrpl47 XM_001064207 0.1 0.03 Mrps10 BG663040 0.13 1.35E-06 Mrps11 NM_173309 -0.11 0.03 Mrps17 NM_001011934 -0.1 5.84E-04 Mrps18b NM_013090 0.14 0.01 Mrps18c XM_001071410 0.08 1.85E-06 Mrps2 ENSRNOT00000027841 0.1 0.01 Mrps26 NM_031151 0.05 2.54E-03 Mrps7 XM_235169 0.18 7.29E-05 Mrs2 AI138044 0.11 0.04 Mrto4 ENSRNOT00000006599 0.09 1.17E-06 Msi2 NM_001010961 -0.09 3.98E-04 Msl31 NM_001037096 -0.1 8.89E-03 Msrb2 ENSRNOT00000010986 -0.09 2.50E-04 Mta1 XM_001058601 -0.06 0.02 Mta3_predicted NM_145184 0.08 8.24E-03 Mtap ENSRNOT00000026914 0.06 0.03 Mtap1a ENSRNOT00000023329 0.1 0.03 Mterfd1 NM_001044286 0.1 9.13E-08 Mterfd2 NM_017209 0.13 2.90E-06 Mtf2 NM_001025743 0.11 2.81E-03 Mtfr1 ENSRNOT00000004638 -0.07 0.02 Mthfd1 ENSRNOT00000023161 0.08 5.49E-05 Mthfs ENSRNOT00000023712 -0.12 2.97E-03 Mtmr2 ENSRNOT00000014435 0.05 0.04 Mtmr7 ENSRNOT00000002500 0.1 0.01 Mto1 NM_144753 -0.08 0.03 Mtp18 ENSRNOT00000006480 0.13 1.76E-05 Mtus1 NM_001080147 -0.08 3.34E-05 Mtx2 NM_001024256 0.1 8.16E-03 Diabetes Page 152 of 288

Mul1 ENSRNOT00000009483 0.09 1.59E-03 Musk XM_001081379 0.09 0.02 Mxi1 NM_001033965 -0.09 0.02 Mybl2 BC082020 0.08 4.38E-03 NM_012631 -0.07 6.97E-03 Mycbp2 ENSRNOT00000014583 -0.25 1.96E-04 Myeov2 ENSRNOT00000023121 0.12 5.74E-04 Myo5b NM_130894 0.07 7.09E-04 Myo7a ENSRNOT00000018489 0.1 1.47E-03 N4bp2l1 ENSRNOT00000035247 -0.11 0.01 Nab1 NM_001008280 0.17 1.40E-11 Nadsyn1 ENSRNOT00000019080 0.07 9.36E-03 Naf1 NM_053604 0.12 5.70E-07 Nanp NM_001012225 0.13 9.38E-04 Nans BC079134 0.1 4.90E-07 Nap1l2 CA504468 -0.09 5.80E-04 Narg1 NM_023095 0.12 6.21E-04 Nars NM_134349 0.08 6.14E-03 Nat1 XM_215424 0.11 0.04 Nat13 ENSRNOT00000020145 0.1 0.03 Nat5 ENSRNOT00000020721 0.12 9.41E-04 Nbr1 NM_012949 -0.07 0.05 Ncaph ENSRNOT00000017571 0.08 0.02 Nck2 NM_031359 0.13 4.99E-04 Ncoa4 BC098771 0.08 0.02 Ncor1 ENSRNOT00000017143 0.16 2.48E-03 Nde1 NM_001025673 0.07 6.39E-03 Ndfip1 NM_001039455 -0.05 0.01 Ndfip2 CR468498 0.09 0.02 Ndg2 704329605J1 0.1 0.05 Ndrg2 BI277056 0.15 2.60E-07 Ndrg4 NM_001025643 -0.11 3.16E-05 Ndst2 g11381244 0.17 0.04 Ndufa5 ENSRNOT00000045130 0.07 3.71E-03 Ndufa8 ENSRNOT00000049985 0.12 0.02 Ndufb5 NM_031737 -0.1 7.49E-04 Ndufb7 703836882J1 0.12 1.46E-03 Ndufb9 XM_001080367 -0.09 1.13E-05 Ndufs3 NM_001029900 0.11 2.03E-05 Ndufs4 NM_053592 -0.09 5.68E-04 Ndufv2 NM_001006985 0.07 1.63E-04 Necap1 NM_053445 -0.12 0.01 Nedd9 ENSRNOT00000011619 0.05 4.38E-03 Nefl NM_001009647 0.08 1.98E-03 Nell2 M83676 -0.08 6.81E-04 Neto2 NM_001008377 -0.1 0.04 Neu1 NM_133539 0.07 1.24E-03 Page 153 of 288 Diabetes

Neurl ENSRNOT00000009859 0.1 3.39E-03 Neurod1 ENSRNOT00000012021 0.1 1.67E-03 Nfam1 NM_053584 -0.07 0.04 Nfe2l2 NM_001013068 0.05 0.04 Nfib NM_031566 -0.25 1.27E-05 Nfix CA334411 0.08 2.57E-03 Nfyb NM_001047883 0.12 0.01 Ngly1 ENSRNOT00000022117 -0.06 0.03 Nibp ENSRNOT00000018837 -0.08 0.04 Nip7 ENSRNOT00000002962 0.06 0.01 Nipsnap3a g4132969 0.1 0.01 Nkiras2 NM_001015009 -0.06 0.03 Nkx2-2 AW433776 0.1 4.47E-04 Nle1 NM_001044245 -0.07 0.03 Nlk ENSRNOT00000005089 0.07 2.52E-04 Nlp NM_024001 0.09 1.37E-03 Nmb XM_001071573 0.14 4.32E-04 Noc4l NM_138826 0.46 7.81E-03 Nol4 CA504943 0.13 6.92E-03 Nolc1 702960653J2 0.17 2.15E-05 Nos2 NM_001047867 0.16 8.59E-04 Nov NM_001024801 0.08 0.01 Npap60 g11379611 0.08 0.02 Npas3 NM_001037209 0.1 9.35E-03 Npc2 ENSRNOT00000028695 -0.05 0.01 Nphp1 NM_022508 0.05 0.02 Nptn 704151317J1 0.06 9.90E-03 Nr2f1 ENSRNOT00000015625 0.07 4.80E-03 Nr3c1 NM_001006960 0.07 0.04 Nr4a3 NM_001039003 0.1 5.40E-04 Nrcam NM_001008286 0.07 4.49E-04 Nrd1 NM_031061 0.1 0.02 Nrep NM_031763 -0.12 1.06E-04 Nrgn NM_057097 0.13 3.48E-08 Nrip3 CB313601 0.1 5.23E-04 Nsfl1c NM_017083 0.2 1.80E-06 Nsun5 NM_153473 0.15 3.11E-03 Nt5c3 CK601822 0.13 2.24E-04 Nt5c3l NM_181480 0.09 0.02 Ntrk2 NM_001024772 0.12 4.75E-05 Nubp2 NM_001009409 0.1 0.02 Nucks1 g3728042 0.07 0.01 Nudt19 BQ204312 0.07 1.70E-03 Nudt4 NM_001014033 -0.09 0.03 Nufip1 ENSRNOT00000059664 0.14 7.78E-15 Numb XM_001055084 0.09 1.41E-05 Nup155 XM_001055639 0.06 9.85E-03 Diabetes Page 154 of 288

Nup35 ENSRNOT00000023029 0.08 4.53E-03 Nup54 NM_001014139 -0.09 0.01 Nup93 NM_001034008 0.05 0.04 Nupl1 NM_001008350 -0.09 7.11E-05 Nupr1 NM_017073 -0.11 2.63E-06 Nus1 ENSRNOT00000037587 0.08 0.04 Nvl ENSRNOT00000057682 0.08 3.79E-03 Nxn NM_053347 0.09 1.79E-04 Nxph1 BG671972 0.16 6.21E-03 Oaf NM_001007008 0.09 0.03 Oat NM_133583 0.08 0.02 Obsl1 NM_001024745 -0.09 4.31E-03 Ocrl NM_001025714 -0.05 0.02 Odf2 ENSRNOT00000035100 0.1 5.73E-04 Odz3 BF390065 -0.08 0.05 Ogdhl NM_019190 -0.08 0.04 Ogfrl1 NM_012985 0.07 9.47E-04 Ogg1 NM_001047862 0.08 2.75E-03 Ola1 ENSRNOT00000035890 0.06 0.04 Olfm1 NM_053573 -0.52 4.53E-27 Olr153 ENSRNOT00000012425 0.06 0.02 Olr1697 NM_001011922 0.11 0.02 Olr260 NM_017029 0.31 2.15E-12 Olr376 XM_001075108 -0.06 0.02 Olr419 NM_031522 0.17 1.26E-03 Olr879 NM_019218 0.04 0.01 Opa3 ENSRNOT00000010010 0.07 0.02 Opcml CK471682 0.08 0.02 Opn3 NM_030866 0.07 0.01 Oprs1 NM_031553 0.11 2.26E-05 Optn NM_138847 0.1 0.01 Orc1l NM_001009422 0.07 2.87E-05 Orc6l ENSRNOT00000017364 0.07 6.30E-04 Ormdl2 XM_001060198 0.11 0.03 Ostm1 ENSRNOT00000014639 0.1 4.17E-03 Ostn NM_001014129 0.08 2.70E-03 Otub2 BC087150 -0.08 3.62E-03 Otud4 NM_022869 0.11 4.19E-03 Otud6b ENSRNOT00000016133 0.06 0.02 Otud7b DV722502 -0.15 5.55E-03 Oxnad1 ENSRNOT00000055922 0.05 6.87E-04 P2ry1 ENSRNOT00000049945 0.13 0.02 Pabpnl1 BC083847 -0.11 7.43E-04 Paf1 ENSRNOT00000021328 0.1 1.11E-06 Pafah1b1 BI300990 -0.06 0.04 Pafah1b2 NM_019380 0.06 4.07E-03 Paip2 NM_001014148 -0.25 7.38E-10 Page 155 of 288 Diabetes

Pak1ip1 NM_031130 0.2 0.05 Pak2 NM_001014273 -0.07 3.32E-03 Palb2 Y00489 0.16 0.04 Pap2d ENSRNOT00000022788 -0.05 0.05 Papd4 NM_017356 -0.08 0.02 Papd5 XM_342138 -0.09 2.39E-03 Papola BC083612 -0.25 3.37E-07 Paqr3 NM_199376 -0.12 5.02E-06 Pard6b NM_017352 0.07 0.03 Parp1 DV722487 0.2 2.31E-09 Pax6 704233939H1 -0.09 0.01 Pbrm1 ENSRNOT00000017976 0.09 8.09E-03 Pcaf NM_201418 0.08 0.03 Pcbp3 NM_031981 0.06 0.03 Pcca ENSRNOT00000001970 0.05 0.02 Pcdh19 ENSRNOT00000007995 0.13 2.91E-10 Pcdh24 NM_001007723 0.08 6.59E-04 Pcdh9 NM_199387 0.05 0.02 Pcdhb4 M55292 0.17 3.74E-04 Pcdhb5 NM_001011891 0.07 0.02 Pcgf3 NM_031707 -0.11 0.02 Pcgf6 NM_001012105 -0.1 1.12E-03 Pck2 ENSRNOT00000025894 -0.08 0.01 Pclo NM_022799 0.09 4.28E-03 Pcm1 ENSRNOT00000013905 0.14 6.28E-03 Pcmtd2 NM_001031639 -0.05 0.02 Pcnx ENSRNOT00000020770 -0.06 0.04 Pctp NM_001004258 0.07 7.40E-04 Pcyox1 NM_001007758 0.07 9.62E-03 Pcyt1a ENSRNOT00000021833 0.09 4.23E-03 Pdcd2 ENSRNOT00000010343 0.15 1.76E-05 Pdcd4 CN543288 -0.1 0.04 Pdcd5 BC100631 0.06 0.04 Pdcl3 ENSRNOT00000011250 -0.07 0.05 Pde3b ENSRNOT00000030146 -0.12 9.53E-05 Pde4a NM_053952 0.07 0.04 Pde4b NM_001004229 0.13 1.52E-04 Pde7a ENSRNOT00000043859 -0.21 6.39E-10 Pde8a NM_001011925 0.08 4.87E-04 Pdgfra ENSRNOT00000000467 0.13 4.43E-06 Pdgfrl ENSRNOT00000014436 0.09 0.03 Pdhb ENSRNOT00000002554 -0.08 2.99E-04 Pdhx ENSRNOT00000004927 0.11 2.83E-04 Pdia2 NM_001025652 -0.07 0.04 Pdia4 ENSRNOT00000011403 0.12 0.02 Pdik1l BE101284 -0.1 0.05 Pdk1 704251230J1 0.15 1.36E-10 Diabetes Page 156 of 288

Pdlim1 L27867 0.13 0.01 Pdlim2 NM_001014090 0.09 0.02 Pdrg1 BP480680 0.1 3.12E-03 Pdzd11 NM_022521 0.15 4.13E-09 Pdzk1ip1 NM_001012108 -0.09 0.05 Pebp1 NM_001025708 0.14 4.14E-09 Peli2 NM_030870 0.07 5.30E-03 Pelo NM_001033927 0.08 8.81E-05 Pepd NM_001000167 0.14 8.41E-03 Pex19 XM_233679 0.17 1.29E-06 Pex26 ENSRNOT00000035637 -0.07 1.74E-03 Pex5 ENSRNOT00000030823 -0.1 9.83E-03 Pfkfb3 NM_001013882 -0.12 5.01E-05 Pfkp NM_001001111 0.09 0.04 Pfn2 NM_030873 -0.1 5.60E-04 Pgam5 NM_001000946 0.12 1.11E-03 Pgap1 NM_001000968 0.1 9.19E-03 Pgm1 NM_001000586 0.1 0.01 Pgm2 M88709 0.11 0.04 Pgm2l1 BQ781541 -0.12 9.59E-08 Pgrmc2 ENSRNOT00000005072 0.12 5.67E-03 Phb NM_030996 0.1 8.69E-05 Phb2 BQ208941 0.13 0.02 Phc1 ENSRNOT00000019359 -0.08 4.34E-03 Phca NM_031064 0.08 7.28E-04 Phf10 NM_024403 -0.08 0.03 Phf19 NM_031783 0.3 1.50E-13 Phf20l1 ENSRNOT00000007564 -0.2 1.06E-03 Phf5a NM_177931 0.07 0.01 Phka2 NM_001013112 -0.06 0.02 Phkg1 NM_001013124 -0.07 3.37E-03 Phlda2 NM_001033690 0.08 8.38E-05 Phlppl ENSRNOT00000051652 -0.1 3.69E-04 Phyhipl NM_145678 0.06 0.02 Pi4k2b NM_144739 -0.11 0.04 Pigc NM_001012103 -0.06 0.04 Pigh ENSRNOT00000044292 0.16 9.40E-10 Pigk NM_001029925 0.08 0.04 Pigq NM_212534 -0.05 0.02 Pigs ENSRNOT00000049841 0.07 0.03 Pigt ENSRNOT00000024924 0.11 0.03 Pigw ENSRNOT00000008725 0.2 0.03 Pih1d1 NM_001012044 -0.08 0.03 Pik3ap1 AI231394 0.19 3.38E-04 Pin1 ENSRNOT00000026751 0.12 1.50E-05 Pir NM_031594 0.09 6.74E-05 Pitpna NM_012800 0.22 5.39E-10 Page 157 of 288 Diabetes

Pja2 NM_001048185 -0.08 0.04 Pkhd1l1 BP498058 0.06 0.04 Pkn3 703860644J1 0.11 4.35E-05 Pkp2 NM_001037356 0.09 1.11E-04 Pla2g12a BQ202601 0.21 3.01E-04 Pla2g6 NM_130403 -0.12 0.01 Plagl1 ENSRNOT00000029041 -0.12 9.44E-03 Plagl2 ENSRNOT00000014568 0.09 0.03 Plcb1 NM_001011926 -0.07 3.84E-03 Plcb4 NM_053561 -0.1 6.16E-07 Plcl1 XM_342112 -0.08 0.02 Pldn ENSRNOT00000056116 0.06 0.03 Plek2 BF393871 0.09 0.02 Plekha3 AJ132895 -0.08 0.04 Plekha8 ENSRNOT00000011481 0.14 2.61E-06 Plod1 NM_033485 0.11 4.56E-03 Pmpca NM_001024252 0.05 0.05 Pnck ENSRNOT00000006313 -0.05 0.01 Pnliprp2 NM_001011945 0.13 1.53E-03 Pnpla6 ENSRNOT00000023866 -0.07 0.02 Pnrc1 ENSRNOT00000016233 -0.12 2.14E-04 Polb NM_012993 0.07 0.01 Pold2 M22631 0.12 3.06E-03 Pold4 ENSRNOT00000042335 0.11 0.01 Pole3 NM_053557 -0.12 5.39E-04 Pole4 ENSRNOT00000024151 0.09 0.02 Polr1e AW529464 0.25 2.92E-04 Polr2d ENSRNOT00000027210 0.06 0.02 Polr2f ENSRNOT00000027206 0.1 0.01 Polr2j NM_001047860 -0.1 0.04 Polr3d g11674874 0.09 0.03 Polr3h NM_017225 0.23 1.86E-11 Pom121 NM_053622 -0.25 3.92E-04 Pomc NM_012744 0.07 0.04 Pomp AF332142 0.06 0.03 Pop4 NM_078622 0.12 0.02 Pop5 M80601 0.13 5.25E-08 Popdc2 ENSRNOT00000017708 0.05 0.03 Pp3111 g4296767 0.16 1.23E-03 Ppap2a NM_017031 0.16 0.03 Ppap2c NM_198767 0.07 0.05 Ppapdc1b BE115015 0.09 0.03 Ppargc1a NM_001044242 0.13 5.04E-08 Ppat 703917484R6 0.11 0.04 Ppfibp1 ENSRNOT00000044147 -0.22 6.93E-08 Pphln1 NM_017365 0.16 1.52E-08 Ppif NM_001007622 0.11 0.02 Diabetes Page 158 of 288

Ppig NM_001014762 0.13 2.34E-07 Ppil2 ENSRNOT00000003872 0.1 0.01 Ppp1cb NM_001024783 -0.08 0.02 Ppp1r3b NM_022948 -0.12 1.24E-05 Ppp1r3d NM_022861 -0.09 0.03 Ppp2ca ENSRNOT00000005486 0.18 0.01 Ppp2cb NM_017236 0.03 0.03 Ppp2r1b XM_001062693 0.11 0.04 Ppp2r2b NM_017213 0.07 2.64E-03 Ppp2r2d NM_001007634 0.07 0.04 Ppp2r5c XM_001077680 -0.25 2.55E-11 Ppp2r5d NM_001009641 0.15 1.43E-05 Ppp3r1 NM_031678 0.08 0.04 Ppp4c ENSRNOT00000028785 -0.06 0.02 Ppp5c NM_206847 0.04 0.05 Ppp6c NM_053290 0.04 0.03 Ppt1 ENSRNOT00000012286 -0.05 0.04 Pqlc1 NM_001025272 0.07 1.04E-03 Pqlc2 NM_201990 0.08 0.05 Pqlc3 NM_017033 0.05 0.04 Praf2 XM_214047 0.07 0.02 Prdm2 704298571J1 0.07 0.01 Prdx3 NM_031851 0.17 7.62E-09 Prep NM_001013035 0.08 1.64E-03 Prkaa2 CO403304 -0.11 0.04 Prkaca NM_022215 -0.1 6.72E-03 Prkar1a ENSRNOT00000000629 -0.12 4.45E-04 Prkcb1 ENSRNOT00000019987 0.15 8.74E-04 Prkdc NM_001099758 -0.05 0.05 Prkrir BQ196118 0.14 7.29E-03 Prmt3 NM_053615 -0.07 7.17E-04 Prmt5 NM_138888 0.07 0.04 Prok2 U59241 -0.12 0.01 Prom1 ENSRNOT00000027972 0.22 3.74E-07 Pros1 AY724477 0.06 6.18E-03 Prpf31 ENSRNOT00000014775 0.15 4.71E-05 Prps2 NM_001007740 0.15 1.59E-08 Prr5 NM_001011953 0.08 3.03E-03 Prrc1 NM_001006602 0.15 1.33E-10 Prss23 ENSRNOT00000019761 0.07 9.60E-03 Prune BC129096 -0.11 3.20E-03 Psat1 ENSRNOT00000010656 -0.05 0.02 Pscdbp NM_001017488 -0.11 1.63E-03 Psd4 NM_194461 0.19 5.04E-08 Psip1 NM_001004254 -0.08 0.02 Pskh1 NM_001025726 -0.05 0.03 Psma3 BC107660 0.17 4.77E-03 Page 159 of 288 Diabetes

Psma7 ENSRNOT00000027818 0.12 7.56E-06 Psmb6 NM_001009474 0.09 0.03 Psmb7 NM_017231 0.14 9.77E-04 Psmc1 CB717516 0.12 0.03 Psmc2 S68987 0.05 0.05 Psmc3 ENSRNOT00000002498 0.11 2.00E-03 Psmc3ip BI289553 0.2 7.70E-04 Psmc5 XM_001061140 0.12 0.02 Psmc6 ENSRNOT00000014125 0.1 2.54E-03 Psmd2 ENSRNOT00000005490 0.06 0.03 Psme3 ENSRNOT00000013528 0.13 3.31E-05 Psrc1 NM_017100 0.05 9.16E-03 Ptcd2 NM_053827 0.1 8.12E-04 Ptchd1 U95920 -0.1 0.02 Ptpmt1 BF404623 0.17 2.92E-03 Ptpn11 NM_001003673 0.1 6.59E-06 Ptprd NM_001000471 -0.08 0.03 Ptpre NM_001047093 -0.11 0.02 Ptprm ENSRNOT00000001668 0.05 7.90E-03 Ptpro NM_057206 0.07 0.01 Ptrh2 ENSRNOT00000026039 0.13 0.01 Punc NM_001013050 0.08 0.03 Purb ENSRNOT00000045851 -0.08 0.02 Pus7 XM_001071977 0.08 9.06E-03 PVR ENSRNOT00000029704 0.12 1.45E-04 Pwp1 ENSRNOT00000009054 -0.09 3.59E-04 Pxn NM_001012147 -0.15 0.03 Pycard ENSRNOT00000021738 0.1 4.62E-03 Pycr2 ENSRNOT00000015009 0.11 2.76E-03 Pycs NM_001031653 0.08 5.47E-04 Pygo1 ENSRNOT00000005943 0.13 2.73E-07 Pygo2 NM_001025009 -0.09 3.20E-03 Pyroxd1 NM_139326 0.07 0.02 Qdpr NM_001100942 0.04 0.02 Qrsl1 DV716055 -0.09 5.93E-05 R3hdml NM_031510 -0.06 0.02 Rab11a NM_031976 -0.06 0.03 Rab13 NM_001009642 0.08 6.51E-03 Rab21 ENSRNOT00000001591 0.09 4.82E-03 Rab24 NM_199113 0.1 3.52E-03 Rab27a NM_001007701 -0.1 5.24E-07 Rab28 NM_172018 0.09 2.87E-04 Rab33b ENSRNOT00000043611 -0.11 0.03 Rab36 NM_019622 -0.1 0.01 Rab4b NM_022538 0.09 0.03 Rab5c NM_139252 0.11 1.94E-04 Rabepk ENSRNOT00000058498 0.1 1.80E-05 Diabetes Page 160 of 288

Rabggta NM_001012460 -0.07 7.02E-04 Rabif NM_031347 0.13 0.03 Rabl2a ENSRNOT00000015928 -0.1 1.98E-07 Rabl4 ENSRNOT00000002905 0.06 7.69E-03 Rabl5 AY724510 0.13 2.07E-06 Rad23b NM_172243 0.2 4.09E-05 Rai12 CF112143 0.07 7.63E-03 Rai14 NM_175707 0.09 4.36E-04 Ralb NM_017040 0.05 0.03 Ralbp1 ENSRNOT00000018009 -0.05 0.05 Ralgps2 AA964952 0.31 1.12E-05 Ran NM_001025418 0.08 2.19E-05 Rangap1 NM_022209 0.26 2.91E-05 Rap1b ENSRNOT00000011378 -0.11 1.33E-04 Rap2b NM_133410 0.12 0.01 Rapgef4 NM_130823 -0.06 2.58E-03 Rars2 NM_144746 0.06 0.02 Rasa1 NM_013135 -0.19 1.64E-08 Rasa3 ENSRNOT00000016819 -0.04 0.03 Rasip1 DV722552 -0.11 1.53E-07 Rassf2 NM_173109 0.1 0.02 Rassf3 AA893698 -0.19 3.82E-14 Rassf5 BC098780 0.11 2.63E-05 Rassf6 NM_017309 0.09 2.85E-03 Raver2 NM_031729 0.06 0.05 Rbbp6 NM_133589 0.11 3.74E-08 Rbm13 NM_001013189 0.14 6.12E-03 Rbm16 ENSRNOT00000023896 0.21 1.07E-03 Rbm17 XM_001058767 0.06 0.03 Rbm24 AI101637 0.07 0.04 Rbm3 NM_022540 0.05 0.01 Rbm34 NM_031324 0.09 0.02 Rbm39 AI709696 0.11 4.95E-03 Rbm41 BC089976 -0.1 1.62E-03 Rbm45 NM_001008290 -0.07 0.02 Rbm9 ENSRNOT00000021228 0.12 8.19E-05 Rbp1 XM_001054376 0.07 0.04 Rc3h2 ENSRNOT00000018025 -0.11 1.27E-04 Rcan2 NM_021751 0.13 2.22E-03 Rcbtb2 NM_031086 0.1 0.01 Rcc2 XM_576044 -0.11 0.02 rCG_22919 ENSRNOT00000025767 -0.11 7.24E-03 rCG_28701 ENSRNOT00000018683 0.13 1.21E-06 Rcn2 NM_001012121 0.1 0.02 Rdm1 ENSRNOT00000037333 -0.07 0.05 Rdx BI281998 0.07 0.01 Reep4 NM_001033887 0.09 3.91E-05 Page 161 of 288 Diabetes

Rell2 NM_001007691 0.18 1.59E-06 Rem2 BE101267 -0.1 1.70E-03 Rfc2 g18186789 0.23 1.00E-03 Rfc4 NM_017280 0.16 1.34E-03 Rfc5 NM_001008217 0.08 2.91E-04 Rfng NM_057099 0.06 3.32E-03 Rfx1 ENSRNOT00000015877 -0.1 1.71E-05 Rfx5 NM_053411 -0.11 4.31E-03 RGD1304587 NM_053532 0.05 0.01 RGD1304598 NM_057123 0.08 8.90E-04 RGD1304704 NM_033236 0.05 0.03 RGD1304719 NM_001008827 -0.06 0.02 RGD1304773 NM_031595 0.09 1.07E-05 RGD1304792 NM_134458 0.06 1.05E-03 RGD1304878 g8497651 -0.08 7.73E-03 RGD1304931 NM_031149 0.1 1.24E-04 RGD1304982 ENSRNOT00000009649 0.1 5.31E-03 RGD1305014 NM_001011894 0.13 6.38E-04 RGD1305038 NM_001000554 -0.09 0.03 RGD1305045 NM_001044302 0.11 1.47E-03 RGD1305090 ENSRNOT00000034992 0.07 0.02 RGD1305138 NM_017318 0.09 1.22E-04 RGD1305215 ENSRNOT00000013584 0.11 2.45E-04 RGD1305222 AW435132 0.16 0.02 RGD1305274 NM_017336 0.14 8.61E-03 RGD1305283 NM_001011969 -0.05 0.03 RGD1305344 NM_001013860 0.06 1.01E-03 RGD1305347 CA507521 0.09 2.87E-03 RGD1305592 NM_032613 -0.09 1.14E-03 RGD1305793 NM_001013195 0.09 1.44E-04 RGD1305938 ENSRNOT00000025149 0.08 0.01 RGD1306344 NM_139040 -0.04 0.03 RGD1306437 NM_017076 0.26 1.21E-11 RGD1306502 ENSRNOT00000041033 -0.05 4.26E-03 RGD1306526 NM_172322 0.11 6.73E-03 RGD1306568 ENSRNOT00000021433 -0.08 0.01 RGD1306582 NM_001012208 0.12 6.07E-07 RGD1306583 CK228566 0.08 0.04 RGD1306595 ENSRNOT00000023806 -0.05 0.04 RGD1306596 ENSRNOT00000037686 0.16 6.81E-04 RGD1306625 ENSRNOT00000018153 -0.08 0.04 RGD1306626 NM_001004234 0.06 7.49E-03 RGD1306862 NM_022390 0.09 0.03 RGD1306880 NM_031092 0.18 2.56E-17 RGD1306924 NM_001004238 0.06 1.22E-03 RGD1306936 NM_001015023 0.09 0.04 RGD1306962 NM_053978 0.06 0.01 Diabetes Page 162 of 288

RGD1307084 NM_017355 0.06 9.03E-03 RGD1307218 ENSRNOT00000000110 0.06 5.10E-03 RGD1307315 NM_001077435 -0.04 0.04 RGD1307390 BF405017 -0.09 9.71E-03 RGD1307410 XM_001081435 0.08 8.12E-04 RGD1307465 ENSRNOT00000018378 -0.08 0.02 RGD1307493 NM_001024871 0.12 8.17E-05 RGD1307509 NM_001007678 0.06 2.25E-03 RGD1307554 NM_024392 -0.07 6.34E-03 RGD1307648 ENSRNOT00000008450 0.06 0.02 RGD1307696 NM_173118 -0.11 4.50E-06 RGD1307736 NM_001017383 0.05 0.02 RGD1307752 NM_001011902 0.08 0.02 RGD1307773 NM_001025275 0.04 0.01 RGD1307943 NM_001001718 0.05 4.42E-03 RGD1308026 NM_001007655 0.06 0.01 RGD1308048 BC100105 -0.12 1.02E-03 RGD1308059 XM_344230 -0.07 0.03 RGD1308134 NM_001009825 -0.06 0.03 RGD1308143 ENSRNOT00000015233 -0.05 0.04 RGD1308154 ENSRNOT00000035717 -0.11 2.26E-06 RGD1308251 NM_001011947 0.12 1.79E-03 RGD1308432 NM_053821 0.13 6.75E-04 RGD1308448 ENSRNOT00000031808 -0.1 3.64E-05 RGD1308470 g18186257 0.09 0.01 RGD1308517 BU760019 0.11 4.52E-06 RGD1308557 NM_001012199 0.06 0.03 RGD1308600 ENSRNOT00000011688 0.1 2.87E-04 RGD1308635 NM_019365 0.08 0.01 RGD1308813 NM_001034952 0.11 4.11E-04 RGD1308915 NM_001025671 0.08 0.02 RGD1309051 XM_001061591 0.09 0.02 RGD1309077 704032976J1 0.08 0.02 RGD1309104 XM_001063932 -0.09 1.43E-04 RGD1309148 NM_145682 -0.05 0.03 RGD1309216 NM_001014002 0.06 0.05 RGD1309228 NM_139094 0.07 0.04 RGD1309360 NM_057155 0.11 0.01 RGD1309437 NM_001013058 0.04 0.05 RGD1309459 g4132748 0.06 0.04 RGD1309522 ENSRNOT00000007367 0.11 2.77E-03 RGD1309605 NM_001014015 0.09 5.88E-04 RGD1309676 NM_173140 -0.11 0.02 RGD1309710 ENSRNOT00000002150 0.1 8.29E-04 RGD1309748 CB737545 0.14 1.49E-03 RGD1309759 ENSRNOT00000056270 0.1 3.23E-03 RGD1309779 ENSRNOT00000058996 -0.11 3.01E-03 Page 163 of 288 Diabetes

RGD1309784 NM_031751 -0.1 0.04 RGD1309802 ENSRNOT00000024476 -0.08 3.18E-03 RGD1309804 NM_012733 0.09 0.02 RGD1309871 NM_001037181 -0.1 9.96E-03 RGD1309979 AF459023 0.1 0.05 RGD1309995 NM_001079886 -0.06 0.04 RGD1310061 NM_199084 0.05 0.04 RGD1310159 DV718624 -0.11 4.29E-04 RGD1310270 NM_001011944 -0.08 0.02 RGD1310351 ENSRNOT00000019647 0.07 2.24E-03 RGD1310358 ENSRNOT00000004901 -0.09 7.46E-05 RGD1310423 NM_017132 0.16 7.32E-10 RGD1310453 NM_001025279 0.12 1.07E-04 RGD1310484 NM_001014149 0.1 0.04 RGD1310553 NM_001014190 -0.1 0.02 RGD1310571 NM_053786 0.06 2.82E-03 RGD1310597 ENSRNOT00000002487 0.09 6.08E-03 RGD1310606 ENSRNOT00000001498 0.06 4.87E-03 RGD1310660 NM_021849 0.08 0.03 RGD1310722 BI296060 -0.09 3.47E-03 RGD1310754 ENSRNOT00000009566 -0.08 8.17E-03 RGD1310769 BI282272 0.12 0.01 RGD1310784 ENSRNOT00000034282 0.09 0.04 RGD1310794 NM_001039099 -0.07 0.04 RGD1310862 ENSRNOT00000032608 -0.11 1.01E-03 RGD1310899 NM_001047874 0.07 1.66E-04 RGD1310964 NM_001042579 -0.07 9.32E-03 RGD1310975 NM_001025126 0.05 0.03 RGD1310994 NM_001007607 -0.11 5.97E-05 RGD1311021 ENSRNOT00000009104 0.1 6.36E-03 RGD1311045 ENSRNOT00000039110 0.07 0.03 RGD1311055 ENSRNOT00000006924 0.05 0.04 RGD1311078 XM_223781 0.13 4.46E-05 RGD1311098 NM_001014025 0.13 3.95E-07 RGD1311122 BC100098 -0.1 0.03 RGD1311154 ENSRNOT00000052246 0.14 3.60E-06 RGD1311164 ENSRNOT00000008364 0.12 2.81E-06 RGD1311260 ENSRNOT00000033715 0.09 0.02 RGD1311267 NM_001017455 -0.1 7.64E-03 RGD1311517 XM_235689 0.12 0.03 RGD1311564 ENSRNOT00000020820 -0.07 9.13E-03 RGD1311575 NM_001014013 0.09 0.02 RGD1311612 XM_001073162 0.07 1.45E-03 RGD1311634 ENSRNOT00000014063 0.08 0.02 RGD1311745 ENSRNOT00000014401 0.08 0.01 RGD1311747 ENSRNOT00000024150 0.09 8.13E-03 RGD1311805 ENSRNOT00000027432 0.13 2.39E-04 Diabetes Page 164 of 288

RGD1311863 NM_001047095 0.06 0.04 RGD1311874 NM_053990 -0.05 0.05 RGD1311892 ENSRNOT00000049867 0.15 1.75E-04 RGD1311925 NM_001033987 -0.1 8.04E-03 RGD1311933 XM_342068 0.07 0.03 RGD1311939 NM_001025411 -0.04 0.04 RGD1311940 ENSRNOT00000006841 0.07 0.02 RGD1311946 ENSRNOT00000014082 0.15 0.02 RGD1359108 ENSRNOT00000011405 -0.09 5.02E-05 RGD1359158 DW318536 -0.12 0.02 RGD1359191 NM_001009635 0.05 0.02 RGD1359508 ENSRNOT00000021001 0.19 7.28E-06 RGD1359529 BF387456 0.08 0.02 RGD1359713 NM_001013908 0.07 2.56E-03 RGD1559496 NM_001029923 0.07 5.53E-03 RGD1559566 NM_001039612 0.18 2.89E-03 RGD1559859 ENSRNOT00000008107 0.08 0.04 RGD1559885 ENSRNOT00000011586 0.13 1.72E-06 RGD1559902 ENSRNOT00000018460 0.1 2.23E-04 RGD1559923 ENSRNOT00000017998 -0.11 7.05E-04 RGD1560065 ENSRNOT00000011970 0.11 3.32E-09 RGD1560186 ENSRNOT00000021944 0.13 2.70E-03 RGD1560258 NM_001009624 0.1 0.01 RGD1560286 ENSRNOT00000038993 0.1 0.04 RGD1560350 ENSRNOT00000010168 0.08 0.04 RGD1560364 BI297991 -0.06 0.05 RGD1560600 CV115971 0.09 5.38E-04 RGD1560608 NM_001013905 0.07 0.02 RGD1560687 BI290140 0.19 4.33E-09 RGD1560873 NM_001013922 0.1 1.71E-05 RGD1560888 BQ210499 0.11 3.46E-04 RGD1560940 ENSRNOT00000014252 0.12 3.90E-03 RGD1561042 NM_019620 0.06 0.03 RGD1561069 ENSRNOT00000005504 0.17 1.11E-04 RGD1561115 ENSRNOT00000018453 0.11 0.04 RGD1561196_predicted CA509333 0.1 3.94E-06 RGD1561205 NM_001014198 0.11 1.14E-04 RGD1561444 NM_001014178 0.14 2.31E-03 RGD1561605 ENSRNOT00000012407 -0.09 0.03 RGD1561670 ENSRNOT00000025386 0.11 2.08E-04 RGD1561807 CK479910 0.15 0.02 RGD1561813 NM_001014226 0.1 0.01 RGD1561832 NM_001013944 0.11 7.23E-05 RGD1561919 NM_001024254 -0.08 0.03 RGD1561972 AW251798 0.19 3.68E-05 RGD1562037 ENSRNOT00000056278 0.08 0.03 RGD1562052 ENSRNOT00000037415 -0.09 0.02 Page 165 of 288 Diabetes

RGD1562099 NM_001008371 0.07 4.06E-03 RGD1562136 g14949127 0.11 0.02 RGD1562153 NM_001033897 0.09 0.01 RGD1562174 EV762422 -0.11 0.03 RGD1562211 NM_001013866 0.08 0.04 RGD1562218 NM_031152 -0.12 2.99E-06 RGD1562316 ENSRNOT00000004159 0.06 0.01 RGD1562339 NM_001013997 0.12 7.00E-03 RGD1562351 ENSRNOT00000022986 0.1 9.28E-03 RGD1562381 ENSRNOT00000003439 0.13 4.75E-03 RGD1562397 BI295726 0.13 0.02 RGD1562449 ENSRNOT00000020810 0.09 1.77E-05 RGD1562502 ENSRNOT00000005664 -0.1 0.04 RGD1562504 NM_001014167 0.1 7.98E-03 RGD1562529 NM_024127 -0.11 0.03 RGD1562618 BU759932 0.09 1.88E-03 RGD1562691 XM_216499 0.07 9.41E-03 RGD1562747 NM_001029920 0.1 5.57E-03 RGD1562767 XM_001060264 0.07 0.03 RGD1562776 703830562J1 0.07 0.01 RGD1562796 AI599496 0.1 2.19E-03 RGD1562871 NM_001025647 0.04 0.04 RGD1562952 NM_198734 -0.08 5.13E-03 RGD1562965 NM_031110 -0.08 2.01E-04 RGD1563099 NM_001024984 0.11 1.52E-07 RGD1563106 NM_024404 -0.07 2.87E-03 RGD1563216 NM_001009316 0.12 1.69E-04 RGD1563319 AI172515 0.1 1.88E-03 RGD1563325 ENSRNOT00000020637 0.11 2.60E-04 RGD1563365 NM_001044235 0.05 0.03 RGD1563422 ENSRNOT00000017800 0.08 1.87E-03 RGD1563438 XM_001065468 0.15 2.51E-03 RGD1563483 ENSRNOT00000005587 0.07 0.03 RGD1563532 ENSRNOT00000023709 0.13 3.59E-04 RGD1563547 NM_001014204 0.06 0.03 RGD1563578 ENSRNOT00000044479 -0.08 0.05 RGD1563612 NM_001011924 -0.12 8.95E-03 RGD1563634 ENSRNOT00000026838 0.08 0.01 RGD1563842 NM_001008307 0.12 4.24E-07 RGD1563853 ENSRNOT00000049060 -0.06 0.04 RGD1563888 ENSRNOT00000010783 -0.1 6.34E-03 RGD1563941 NM_001013967 0.08 9.04E-04 RGD1563952 NM_001014072 0.1 1.37E-03 RGD1563973 ENSRNOT00000002908 0.08 0.04 RGD1564174 NM_001044243 -0.07 0.03 RGD1564209 XM_001077667 -0.11 3.80E-06 RGD1564268 ENSRNOT00000019993 0.09 2.67E-03 Diabetes Page 166 of 288

RGD1564369 ENSRNOT00000055252 0.12 2.60E-06 RGD1564420 NM_001008329 0.04 0.03 RGD1564452 ENSRNOT00000015130 0.04 0.04 RGD1564454 NM_001009625 -0.11 7.19E-05 RGD1564456 ENSRNOT00000032301 -0.09 0.01 RGD1564469 ENSRNOT00000009530 -0.09 0.02 RGD1564579 CA504213 -0.1 0.02 RGD1564704 NM_001009638 0.1 0.03 RGD1564719 NM_001034149 0.21 1.20E-14 RGD1564748 NM_001024974 0.11 9.95E-04 RGD1564763 ENSRNOT00000016989 0.06 0.04 RGD1564778 XM_001081442 -0.05 0.04 RGD1564804 ENSRNOT00000013623 0.08 6.60E-03 RGD1564887 DV714531 -0.09 0.04 RGD1565002 NM_001007657 0.12 5.33E-03 RGD1565045 NM_212510 -0.08 2.76E-03 RGD1565059 BP466301 -0.05 6.45E-03 RGD1565310 NM_172062 -0.09 0.04 RGD1565362_predicted ENSRNOT00000024827 -0.09 9.73E-03 RGD1565373 NM_001007706 0.12 1.76E-03 RGD1565432 NM_001025716 0.07 8.34E-03 RGD1565556 NM_001009707 0.09 2.85E-03 RGD1565561 NM_001014193 0.08 2.18E-03 RGD1565689 NM_001017502 -0.08 0.01 RGD1566189 NM_001005882 0.2 5.88E-19 RGD1566319 NM_031812 -0.05 6.13E-03 RGD1566320 ENSRNOT00000038245 0.12 1.92E-04 RGD1566325 NM_001013089 -0.1 6.09E-03 RGD1566355 XM_347117 0.14 2.70E-04 RGD1566370 g11407540 0.07 0.04 RGD1566386 XM_577822 0.13 5.13E-05 RGD1566396 ENSRNOT00000019964 0.15 1.15E-10 RGD621098 NM_001024755 0.08 5.94E-03 RGD708545 ENSRNOT00000049634 0.05 9.77E-03 RGD735065 ENSRNOT00000020806 -0.07 0.02 Rgs16 ENSRNOT00000013089 -0.1 7.31E-03 Rgs17 ENSRNOT00000001218 0.05 0.02 Rhbdd1 BQ782704 -0.04 0.04 Rhbdd2 ENSRNOT00000045226 0.08 1.06E-04 Rhobtb2 ENSRNOT00000034499 0.11 0.03 Rhoc ENSRNOT00000008057 0.1 1.60E-03 Rhod XM_576104 0.09 0.01 Rhoq NM_138915 -0.1 8.49E-03 Rhpn2 ENSRNOT00000052297 0.11 0.05 Rims2 ENSRNOT00000056024 -0.1 5.07E-03 Riok2 CA508347 0.09 0.05 Riok3 ENSRNOT00000012551 0.12 0.05 Page 167 of 288 Diabetes

Ripply2 XM_001061556 0.06 0.01 Rkhd2 NM_001009662 -0.11 0.02 Rnaseh2a NM_001025707 -0.07 0.03 Rnaseh2b ENSRNOT00000048655 0.16 1.58E-03 Rnd3 NM_001044259 0.09 4.39E-04 Rnf121 ENSRNOT00000040965 0.1 0.05 Rnf125 ENSRNOT00000016882 -0.09 0.01 Rnf139 ENSRNOT00000012842 0.08 3.37E-03 rnf141 NM_001013925 -0.06 0.02 Rnf144a NM_001007663 -0.05 0.05 Rnf149 ENSRNOT00000056229 0.15 1.62E-06 Rnf166 ENSRNOT00000026327 -0.1 2.98E-03 Rnf17 ENSRNOT00000031893 0.06 0.02 Rnf185 ENSRNOT00000057447 0.18 0.05 Rnf19a NM_053603 -0.07 1.73E-04 Rnf217 ENSRNOT00000045477 0.05 0.05 Rnf38 ENSRNOT00000014010 -0.1 6.20E-03 Rnft1 ENSRNOT00000037478 0.12 0.03 Rnps1 NM_131913 0.09 8.07E-03 Robo1 ENSRNOT00000018548 -0.09 8.80E-08 Robo2 XM_001080370 0.13 1.17E-03 rp9 ENSRNOT00000033359 0.1 1.56E-03 Rpa2 ENSRNOT00000024527 0.07 0.04 Rpain ENSRNOT00000045749 0.07 0.02 Rpe XM_576285 0.08 6.88E-04 Rpia ENSRNOT00000008279 -0.08 0.03 Rpl7l1 BQ201615 0.07 0.04 Rpo1-1 ENSRNOT00000029397 0.13 0.01 Rpo1-2 ENSRNOT00000017296 0.12 0.01 Rpp21 XM_001062525 0.06 0.04 Rps19bp1 ENSRNOT00000040565 0.08 1.53E-04 Rps6ka2 704304832H1 -0.09 2.43E-03 Rps6ka3 ENSRNOT00000013599 0.18 2.16E-05 Rps6kc1 ENSRNOT00000041516 0.05 0.04 Rps7 AW919316 0.12 3.34E-03 RragB NM_001012190 -0.11 9.63E-03 Rragc BC087667 -0.07 0.04 Rras2 NM_001013434 -0.32 3.05E-10 Rsl1d1 ENSRNOT00000021637 0.09 0.02 RT1-Aw2 BF399605 -0.08 3.12E-03 RT1-Bb ENSRNOT00000056518 0.07 0.02 Rtbdn BI291377 -0.06 0.03 Rtel1 NM_001008556 -0.1 0.01 Rtp1 ENSRNOT00000006092 0.09 0.02 Rtp3 DY471823 -0.08 1.14E-03 Rttn CK478027 -0.07 6.35E-03 Rundc1 ENSRNOT00000039889 0.09 5.68E-03 Diabetes Page 168 of 288

Runx1 XM_001063505 0.08 0.05 Ruvbl1 ENSRNOT00000050807 0.09 0.04 Rwdd1 ENSRNOT00000015883 0.08 0.04 Ryk XM_576075 0.12 6.13E-09 Ryr2 BQ192644 -0.08 0.01 S100a1 ENSRNOT00000027344 0.34 2.68E-03 S100a16 702992208T1 0.16 9.78E-09 S100g ENSRNOT00000024976 -0.07 0.01 Sacm1l NM_001077643 0.05 0.04 Sae1 ENSRNOT00000056870 0.1 0.02 Sall1 XM_226329 -0.08 8.75E-03 Samd10 ENSRNOT00000034101 0.09 0.04 Sap130 XM_346881 0.07 9.92E-03 Sap18 NM_001081447 0.05 7.70E-04 Sap30bp ENSRNOT00000009701 0.06 0.04 Sap30l ENSRNOT00000003473 -0.14 3.21E-04 Saps1 ENSRNOT00000007754 0.05 0.02 Saps3 XM_001071071 0.18 7.66E-08 Sart3 NM_207592 -0.07 0.03 Satb2 ENSRNOT00000026075 -0.09 0.05 Sbno1 ENSRNOT00000038055 0.14 5.94E-04 Sc5d ENSRNOT00000035404 0.09 9.41E-03 Schip1 ENSRNOT00000041359 0.07 0.01 Scn7a g3248368 -0.1 0.02 Sco1 NM_001025683 0.27 3.46E-03 Scoc XM_238631 0.13 0.05 Scp2 ENSRNOT00000013315 0.06 2.76E-03 Scpep1 NM_001100136 0.04 0.05 Scrib ENSRNOT00000003544 -0.1 1.82E-05 Scrn3 NM_001001800 -0.11 0.04 Scrt2 ENSRNOT00000044808 0.16 1.57E-06 Sdad1 ENSRNOT00000033396 0.08 0.04 Sdc2 ENSRNOT00000042622 0.09 8.27E-03 Sdf2 XM_228426 0.1 0.03 Sec22b ENSRNOT00000045710 0.08 0.04 Sec23a ENSRNOT00000009044 0.11 2.06E-05 Sec63 ENSRNOT00000007645 0.08 4.91E-03 Sel1l NM_001044233 0.05 0.02 SELS ENSRNOT00000059269 0.1 0.01 Sema4b ENSRNOT00000002560 -0.07 0.04 Sema6a XM_001054004 -0.16 0.03 Sephs1 CO569364 -0.14 3.25E-04 Serf2 ENSRNOT00000059774 0.16 4.27E-04 Serp1 XM_001077872 0.07 9.99E-03 Serping1 NM_001013059 -0.11 3.03E-05 Serpini1 ENSRNOT00000055588 0.13 1.48E-09 Setd4 ENSRNOT00000007173 0.07 0.03 Page 169 of 288 Diabetes

Setd6 BC089998 0.23 9.08E-08 Sf4 NM_133409 -0.11 1.18E-08 Sfpq XM_226119 -0.11 0.03 Sfrp1 ENSRNOT00000028927 0.09 0.05 Sfrs1 DV721035 -0.36 4.98E-22 Sfrs11 NM_139260 -0.09 9.06E-03 Sfrs12ip1 ENSRNOT00000010672 0.08 4.02E-05 Sfrs18 NM_001033971 0.06 0.01 Sfrs9 ENSRNOT00000025355 0.1 0.03 Sft2d1 ENSRNOT00000001962 0.1 5.28E-04 Sft2d2 NM_013070 -0.09 0.02 Sft2d3 NM_001013133 0.09 0.04 Sfxn2 EV779899 0.14 1.14E-05 Sfxn3 NM_012565 -0.06 0.04 Sfxn4 ENSRNOT00000026092 0.09 0.04 Sgk3 XM_001060531 -0.33 5.60E-11 Sgsm1 NM_198751 -0.09 0.01 Sh2b2 ENSRNOT00000009621 -0.1 4.30E-04 Sh2b3 ENSRNOT00000016148 0.16 4.00E-03 Sh2d5 NM_023960 -0.1 0.03 Sh3bp5 NM_001013185 -0.1 0.02 Sh3gl2 g3707924 0.16 7.29E-04 Sh3glb1 ENSRNOT00000013285 0.1 8.46E-03 Shank1 NM_001001512 -0.04 0.05 Shank2 DY316927 -0.07 0.01 Shoc2 ENSRNOT00000060467 -0.08 0.03 Siae NM_022934 -0.12 3.46E-06 Sil1 NM_001005542 -0.06 0.03 Sirt5 NM_001007007 0.06 0.04 Sirt7 NM_001007641 0.08 0.03 Skip DY472808 -0.09 0.04 Skp1a CN542239 0.1 7.57E-04 Slain2 ENSRNOT00000018684 0.16 5.43E-03 Slc10a4 XM_001073394 0.12 5.93E-03 Slc11a2 ENSRNOT00000010795 0.07 0.04 Slc12a2 CN541977 0.1 2.10E-03 Slc12a3 NM_001024271 0.1 0.01 Slc12a6 NM_031091 -0.09 0.04 Slc12a7 XM_001057827 0.09 5.96E-03 Slc16a1 ENSRNOT00000005064 0.13 0.02 Slc16a3 ENSRNOT00000044546 0.17 8.27E-04 Slc17a6 ENSRNOT00000046509 0.17 2.38E-05 Slc24a5 DY471480 -0.06 0.02 Slc25a12 ENSRNOT00000001477 -0.11 0.04 Slc25a14 NM_021582 0.06 0.01 Slc25a16 NM_001033060 0.09 7.75E-03 Slc25a19 NM_001033903 0.15 1.83E-04 Diabetes Page 170 of 288

Slc25a20 ENSRNOT00000000804 -0.12 0.02 Slc25a24 CA505411 0.11 0.02 Slc25a32 NM_001008330 0.11 4.12E-07 Slc25a35 NM_031773 0.09 8.29E-06 Slc29a4 XM_233671 -0.06 0.02 Slc2a1 NM_001002831 0.07 0.02 Slc2a4 BQ210611 -0.09 0.03 Slc2a6 CB732422 -0.08 0.03 Slc30a4 ENSRNOT00000009154 0.1 6.10E-03 Slc30a5 ENSRNOT00000024085 0.07 5.49E-04 Slc30a8 ENSRNOT00000008938 0.09 2.13E-03 Slc31a1 BF401605 0.06 0.03 Slc31a2 NM_019148 -0.11 1.51E-04 Slc35a3 ENSRNOT00000014135 0.11 6.61E-03 Slc35b4 NM_031570 0.09 7.68E-03 Slc35c1 XM_001071554 0.11 0.01 Slc35d3 BP488655 -0.08 0.04 Slc35e1 CO567953 0.08 0.02 Slc35e3 AJ554215 0.13 0.02 Slc35f5 ENSRNOT00000032383 0.11 0.01 Slc36a1 XM_001081465 0.06 6.84E-03 Slc38a1 g3291219 0.12 2.19E-03 Slc38a2 ENSRNOT00000005059 -0.08 3.17E-03 Slc38a9 NM_147177 0.05 0.05 Slc39a11 NM_147146 0.07 0.01 Slc39a13 NM_080402 0.07 1.61E-03 Slc40a1 NM_001007636 0.08 6.32E-03 Slc44a3 NM_031102 -0.1 8.85E-04 Slc44a4 ENSRNOT00000016499 0.05 0.04 Slc5a3 NM_031034 -0.11 1.02E-03 Slc6a5 NM_053798 0.09 7.28E-03 Slc6a8 NM_001012063 0.08 0.01 Slc7a1 BC099100 0.06 0.03 Slc7a6 ENSRNOT00000022761 0.11 0.02 Slc9a3r2 NM_001033685 0.05 0.03 Slc9a6 ENSRNOT00000007362 0.09 1.76E-03 Slfn8 ENSRNOT00000024400 0.1 0.03 Slit2 NM_001000260 -0.11 0.03 Slk NM_181767 -0.08 0.03 Smad4 ENSRNOT00000014333 -0.08 0.02 Smad5 XM_001067905 0.08 6.62E-03 Smad6 ENSRNOT00000057902 0.06 0.03 Smarcc1 AB052846 0.09 8.12E-04 Smarce1 ENSRNOT00000057473 0.07 0.03 Smc2 ENSRNOT00000044116 0.09 0.02 Smgb ENSRNOT00000011719 0.06 0.04 Smn1 ENSRNOT00000045200 0.08 0.02 Page 171 of 288 Diabetes

Smpd1 NM_001047877 -0.09 0.04 Smpd3 NM_198732 -0.09 1.62E-05 Smurf2 NM_133383 0.07 1.88E-04 Snap25 ENSRNOT00000006833 0.09 3.19E-03 Snap29 NM_001006958 0.08 6.93E-04 Snapc1 CF109446 0.11 7.07E-03 Snapc5 ENSRNOT00000016297 0.05 0.02 Snca NM_130428 0.04 0.05 Snf1lk NM_001025686 0.11 2.71E-05 Snhg8 XM_347236 0.15 1.52E-03 Snip1 ENSRNOT00000011553 0.07 5.81E-03 Snrpc ENSRNOT00000000345 0.11 2.86E-06 Snupn ENSRNOT00000045285 -0.08 0.03 Snx10 NM_173120 0.11 2.92E-07 Snx13 NM_001009687 0.08 2.28E-03 Snx16 NM_001098782 0.32 9.82E-13 Snx2 NM_030835 0.06 5.08E-03 Snx27 ENSRNOT00000023946 -0.11 0.02 Snx7 NM_053779 0.13 4.49E-04 Snx8 ENSRNOT00000000330 0.14 4.35E-06 Soat1 ENSRNOT00000011891 0.11 2.45E-06 Socs4 ENSRNOT00000002308 0.09 0.01 Sort1 ENSRNOT00000016626 0.15 0.02 Sos1 XM_001062567 -0.2 7.20E-06 Sp110 NM_173307 -0.09 1.43E-04 Spag7 ENSRNOT00000035084 0.11 2.51E-05 Spast ENSRNOT00000024128 0.11 0.02 Spata2 NM_001008373 0.1 1.43E-03 Spata20 XM_001055560 0.13 1.76E-03 Spc25 ENSRNOT00000010084 -0.09 0.05 Spdef NM_001009255 0.09 6.57E-06 Specc1l ENSRNOT00000015562 0.1 1.88E-05 Spg20 NM_001007679 -0.08 0.05 Sphkap NM_001008302 0.05 7.07E-04 Spint1 XM_001059433 0.19 7.85E-11 Spock1 ENSRNOT00000054674 0.12 0.04 Sppl2b NM_031621 0.15 2.68E-03 Spred1 ENSRNOT00000031868 -0.11 0.04 Spry1 ENSRNOT00000058495 -0.14 0.01 Sqle ENSRNOT00000008999 0.13 2.53E-03 Sqstm1 NM_001011929 0.06 2.22E-04 Sra1 NM_001004256 0.06 0.02 Srd5a1 ENSRNOT00000054951 0.23 2.26E-09 Srd5a3 NM_001007608 0.04 0.02 Ss18l1 BF407634 0.05 9.60E-03 Ssbp1 NM_001008555 0.2 2.61E-04 Ssh2 NM_001013239 0.16 1.92E-06 Diabetes Page 172 of 288

Sspn 702955168H1 -0.07 0.05 Ssr2 NM_013173 0.14 3.42E-04 Ssr3 ENSRNOT00000014888 -0.07 0.03 Sstr2 BQ201903 0.16 0.04 Ssx2ip ENSRNOT00000026375 -0.12 0.01 St14 NM_019345 0.09 0.02 St3gal3 ENSRNOT00000060933 0.1 0.02 St3gal4 NM_012716 0.27 3.18E-04 St3gal5 NM_053427 0.1 0.03 St6gal1 ENSRNOT00000009841 -0.09 1.54E-03 Stag2 NM_053501 0.06 0.02 Stard5 ENSRNOT00000029576 0.2 2.86E-03 Stard7 NM_001007674 0.05 0.01 Stch CO573750 -0.06 0.04 Steap3 ENSRNOT00000027765 0.15 0.02 Stim2 NM_001034021 -0.05 0.04 Stk17b ENSRNOT00000006029 0.13 2.91E-04 Stk19 ENSRNOT00000006597 0.18 5.73E-08 Stk24 BI295980 -0.07 0.04 Stmn1 ENSRNOT00000054696 -0.1 0.01 Stom NM_001013996 0.16 5.44E-07 Stra6 NM_001037186 0.15 1.98E-08 Strn NM_017182 -0.05 0.03 Strn4 NM_022943 -0.09 3.70E-03 Stx18 NM_138827 0.08 4.84E-03 Stx6 BC086981 0.18 9.47E-04 Stxbp1 NM_013175 -0.08 0.04 Stxbp3 NM_012508 -0.09 0.02 Suds3 ENSRNOT00000023654 -0.07 0.02 Sufu BC107651 0.06 0.04 Sult2b1 ENSRNOT00000024543 -0.12 6.20E-06 Sumf1 NM_133600 0.09 0.03 Suv420h1 ENSRNOT00000025711 -0.08 2.26E-03 Sv2a NM_019905 -0.12 3.19E-04 Syap1 NM_001012082 0.2 1.19E-06 Sycp2 NM_001025144 -0.1 7.22E-05 Synj2bp ENSRNOT00000012179 0.09 7.74E-03 Synpo2 ENSRNOT00000010278 0.16 6.47E-06 Sypl2 BF522926 -0.09 9.02E-03 Syt13 ENSRNOT00000022905 -0.11 0.01 Syt8 BC091412 0.13 9.99E-08 Tacc2 704310195J1 -0.08 0.04 Tacc3 ENSRNOT00000004581 0.11 1.88E-05 Taf1 NM_017198 -0.09 0.04 Taf13 NM_130415 0.1 8.72E-03 Taf6l NM_138832 0.17 3.11E-04 Tagln3 NM_001035251 0.11 1.93E-03 Page 173 of 288 Diabetes

Tarsl2 NM_001013235 0.09 9.04E-06 Tas1r1 ENSRNOT00000026974 -0.09 2.04E-07 Tbc1d22b NM_053826 -0.04 0.05 Tbcc NM_001013042 0.14 0.04 Tbcd NM_001039196 0.08 2.80E-03 Tbrg4 NM_133315 0.1 3.22E-03 Tc2n ENSRNOT00000011572 0.14 0.01 Tceal8 NM_212541 0.2 3.38E-06 Tceb2 NM_203334 0.1 0.01 Tceb3 CK843382 0.08 0.03 Tcfap2c ENSRNOT00000001234 0.12 4.66E-03 Tcfcp2l2 NM_012603 -0.12 7.44E-03 Tcp11l2 NM_031573 -0.12 4.25E-03 Tdg BC091390 -0.08 0.01 Tdrd6 ENSRNOT00000027117 0.2 7.83E-21 Tdrd7 NM_031770 -0.12 8.96E-03 Tex15 NM_177933 0.07 0.02 Tex264 NM_153470 -0.1 0.04 Tfb1m NM_053811 0.09 6.67E-03 Tfb2m NM_153625 -0.07 5.71E-03 Tgfa CB324099 0.09 0.03 Tgfbr1 NM_022594 -0.06 0.02 Tgif1 ENSRNOT00000040072 -0.08 5.58E-04 Tgm2 NM_053739 -0.09 2.70E-03 Tgoln1 NM_001039037 0.1 1.16E-06 Tgs1 NM_001009661 0.09 2.84E-06 Thap1 NM_053438 -0.06 3.16E-03 Them4 NM_001013970 0.07 0.02 Thnsl1 CV110726 0.11 2.92E-03 Thnsl2 NM_032617 -0.05 0.04 Thoc1 ENSRNOT00000012155 0.11 0.02 Thoc3 CA505347 0.13 3.26E-05 Thoc5 NM_001024993 0.09 1.04E-03 Thra NM_001008886 -0.09 0.04 Thrb XM_342837 0.09 6.89E-04 Tia1 BP485693 0.12 7.98E-03 Timm13 NM_022509 0.09 1.75E-04 Timm17b ENSRNOT00000019781 0.21 1.00E-13 Timm44 XM_001078712 -0.08 1.63E-03 Timm8a1 CB577522 0.12 0.05 Timm8b NM_053810 0.11 2.38E-03 Timm9 ENSRNOT00000010871 -0.39 3.97E-29 Timp4 ENSRNOT00000012361 0.13 2.47E-05 Tipin NM_198785 -0.07 0.03 Tlcd1 AA892538 0.17 1.04E-08 Tle2 M31322 -0.09 0.03 Tloc1 AW529324 -0.09 7.94E-03 Diabetes Page 174 of 288

Tm2d1 CK226786 0.18 5.11E-05 Tm2d2 NM_019169 0.15 8.96E-08 Tm2d3 ENSRNOT00000001579 0.16 2.57E-03 Tm6sf1 ENSRNOT00000061204 0.09 0.01 Tm9sf2 NM_001014069 0.07 3.85E-03 Tmed1 ENSRNOT00000000586 0.07 3.82E-03 Tmed9 NM_001013085 0.1 0.03 Tmem111 704238932J1 0.14 6.56E-04 Tmem115 NM_022289 0.13 1.82E-06 Tmem120a XM_214539 0.05 0.03 Tmem123 NM_001012083 0.14 4.67E-07 Tmem126a ENSRNOT00000001696 0.11 2.51E-07 Tmem126b AI236009 0.2 5.41E-06 Tmem141 ENSRNOT00000015120 0.22 4.43E-03 Tmem14a BE110483 0.17 1.25E-04 Tmem157 ENSRNOT00000039375 0.07 0.01 Tmem163 NM_030834 0.06 0.04 Tmem165 NM_053675 0.07 0.01 Tmem16c NM_199402 0.1 0.01 Tmem16f ENSRNOT00000012260 -0.03 0.03 Tmem175 ENSRNOT00000000583 0.12 2.05E-03 Tmem177 ENSRNOT00000022281 0.1 1.37E-03 Tmem178 NM_001004265 0.07 0.01 Tmem189 ENSRNOT00000017016 0.11 8.93E-03 Tmem192 ENSRNOT00000010022 -0.12 7.42E-05 Tmem199 NM_001014200 0.16 0.03 Tmem2 ENSRNOT00000017212 -0.23 3.98E-05 Tmem208 ENSRNOT00000014546 0.04 0.03 Tmem209 CV127014 -0.1 9.37E-03 Tmem30a ENSRNOT00000006849 -0.1 0.03 Tmem33 NM_017136 0.08 0.03 Tmem34 NM_181550 0.09 1.02E-03 Tmem38b ENSRNOT00000006410 0.1 3.33E-03 Tmem49 NM_138839 0.15 2.37E-08 Tmem5 NM_183329 0.1 6.10E-08 Tmem50b NM_017070 0.12 2.96E-04 Tmem55a NM_001013990 0.08 0.03 Tmem55b BM391692 -0.09 0.02 Tmem56 703865440J1 0.09 0.02 Tmem62 NM_053464 0.07 0.04 Tmem66 NM_001013252 0.1 1.55E-04 Tmem80 NM_001017932 0.08 0.03 Tmem85 NM_183328 0.06 0.02 Tmem87b XM_001070197 0.05 1.03E-03 Tmem9 g4609194 -0.12 4.16E-03 Tmem93 NM_001039163 -0.09 0.03 Tmem97 NM_019348 0.19 7.75E-03 Page 175 of 288 Diabetes

Tmem9b NM_053635 0.04 0.03 Tmod2 ENSRNOT00000014301 -0.08 3.57E-05 Tmpo NM_031697 0.14 0.04 Tmtc2 XM_001080732 -0.14 0.05 Tnfrsf12a NM_203337 0.05 0.05 Tnfsf9 BF399604 0.08 0.03 Tnip1 NM_022584 -0.06 0.04 Tnk1 ENSRNOT00000015320 0.31 3.34E-14 Tnks2 XM_238280 0.06 0.02 Tnrc6a NM_133392 0.12 0.01 Tob1 NM_001013197 0.06 0.04 Tomm22 NM_001011965 0.06 0.03 Tomm34 CB728001 0.07 0.03 Tomm40 NM_001012151 0.09 7.49E-03 Tomm40b g13303464 0.1 5.22E-03 Tomm70a NM_001024899 0.11 7.14E-03 Top1 NM_021692 0.1 3.16E-04 Tor1aip2 ENSRNOT00000009008 0.07 8.46E-04 Tor1b g6163684 -0.11 0.01 Tor3a g3666757 0.15 0.02 Tpcn1 704155260J1 0.11 6.27E-07 Tpd52 BQ783056 0.11 4.90E-05 Tpm3 ENSRNOT00000019931 0.24 6.39E-13 Tpr CA512514 -0.1 2.37E-03 Traf3 NM_053325 0.07 0.03 Traf3ip2 NM_134335 -0.08 0.02 Traf6 NM_080896 -0.1 1.85E-06 Traip NM_001004424 0.07 7.67E-04 Tram1l1 ENSRNOT00000027530 0.11 8.28E-04 Trap1 ENSRNOT00000026284 0.11 0.04 Trappc3 NM_001035236 0.09 4.23E-03 Trh NM_001014020 0.06 0.03 Trib2 ENSRNOT00000005774 -0.2 2.21E-08 Trim25 ENSRNOT00000009402 -0.12 1.66E-04 Trim31 703906453J1 0.07 0.01 Trim37 NM_022398 -0.07 0.04 Triobp XM_343649 0.08 2.13E-04 Trmt12 NM_001012154 0.08 9.89E-04 Trp53i11 NM_001085475 -0.11 0.02 Trp53i13 NM_001025152 0.19 9.36E-11 Trpa1 NM_001014275 0.08 0.01 Trpc2 NM_031129 0.06 0.02 Trpm3 ENSRNOT00000012578 -0.08 0.04 Trpv1 NM_001012219 -0.11 0.02 Trub1 ENSRNOT00000028495 -0.07 0.04 Tsc22d3 ENSRNOT00000007016 -0.12 1.19E-03 Tsen34 CB770356 -0.12 5.55E-03 Diabetes Page 176 of 288

Tshr NM_017103 0.12 1.51E-03 Tspan11 ENSRNOT00000020455 0.16 2.50E-12 Tspan12 XM_001078410 0.09 0.04 Tspan13 ENSRNOT00000038239 0.09 0.04 Tspan18 g11396596 0.18 0.05 Tspan3 NM_181474 0.15 1.24E-04 Tspan33 NM_012671 0.08 6.21E-05 Tspan4 NM_182823 0.06 0.03 Tspan6 NM_001025017 0.07 0.02 Tspyl2 g3710396 0.07 0.03 Tspyl4 ENSRNOT00000000116 0.04 0.03 Tsta3 NM_001012153 0.07 9.63E-03 Ttc13 ENSRNOT00000008989 0.19 5.33E-03 Ttc14 NM_001007661 0.07 0.01 Ttc25 NM_001012207 -0.12 1.47E-04 Ttc5 704208701H1 -0.1 0.01 Ttc7b ENSRNOT00000015343 0.11 0.04 Ttc8 NM_001007615 0.05 0.03 Ttk NM_145781 0.11 4.91E-05 Ttyh3 NM_001014206 -0.09 0.01 Tuba1c ENSRNOT00000037066 0.09 0.03 Tuba4a AF150082 0.13 2.09E-04 Tubb6 NM_022541 0.14 4.35E-08 Tuft1 AI411222 0.06 0.02 Tusc1 NM_001013858 0.12 6.68E-03 Twistnb AI575294 -0.1 2.51E-03 Txn2 ENSRNOT00000009897 0.07 3.67E-03 Txndc15 ENSRNOT00000022076 -0.06 0.03 Txndc17 NM_001017444 0.14 3.34E-12 Txnip AI030851 -0.12 4.16E-03 U1snrnpbp ENSRNOT00000015287 0.1 9.67E-07 Uap1l1 ENSRNOT00000026714 0.07 0.02 Uba3 ENSRNOT00000005653 -0.05 0.01 Uba5 NM_001005554 0.06 0.02 Ubd NM_198738 -0.11 4.40E-05 Ube2d1 NM_133385 -0.1 0.01 Ube2d3 NM_001008510 -0.12 2.66E-03 Ube2e2 NM_001013432 0.1 0.01 Ube2e3 NM_053467 0.06 6.67E-03 Ube2j1 NM_138918 0.11 0.02 Ube2j2 NM_001009703 0.13 8.97E-09 Ube2l6 NM_001008355 0.06 0.03 Ube2q1 ENSRNOT00000032263 0.08 0.03 Ube2t NM_001010945 0.18 1.86E-04 Ube4b NM_001014205 0.13 3.89E-03 Ubfd1 AI170944 0.15 1.88E-07 Ublcp1 CK473297 0.21 2.89E-18 Page 177 of 288 Diabetes

Ubtd2 ENSRNOT00000033701 0.09 4.55E-03 Uchl5ip ENSRNOT00000037489 0.15 1.56E-06 Uckl1 NM_001007736 -0.06 4.46E-03 Ucn2 NM_001039346 0.11 2.40E-04 Ufm1 AW530939 0.17 2.47E-05 Ugdh NM_001012350 0.06 0.03 Unc119b AI576050 0.14 0.03 Unc5c NM_001024802 0.1 3.71E-08 Upb1 XM_213675 -0.09 0.04 Uqcrc1 XM_001080134 0.12 0.03 Uqcrh NM_001013991 0.1 0.02 Usp11 NM_001037776 0.08 8.03E-03 Usp15 NM_001004282 0.13 3.16E-04 Usp25 ENSRNOT00000020816 0.11 7.63E-03 Usp31 703893835J1 0.16 2.98E-06 Usp38 NM_001024992 0.04 0.04 Usp39 ENSRNOT00000021723 0.1 3.74E-04 Usp9x CK839458 -0.12 9.20E-03 Uspl1 NM_001034198 0.08 2.45E-03 Utp3 NM_178330 0.07 0.02 Uxs1 NM_001014191 0.15 2.89E-04 Vamp1 NM_001024759 0.07 6.34E-03 Vamp3 NM_001025014 0.12 3.67E-03 Vangl1 NM_001024900 0.14 4.54E-04 Vangl2 ENSRNOT00000010210 -0.04 0.02 Vash1 NM_001004237 -0.05 5.85E-04 Vasn XM_001073749 0.24 7.74E-04 Vat1 NM_017275 -0.11 4.45E-06 Vcl AI407421 0.08 0.05 Vdac2 NM_053581 -0.09 1.74E-05 Vegfa CK478090 -0.12 1.02E-05 Veph1 CO571211 0.05 0.03 Vgll4 ENSRNOT00000019919 -0.07 0.04 Vil1 ENSRNOT00000007612 0.07 3.77E-03 Vipr1 ENSRNOT00000006436 -0.1 1.79E-08 Visa ENSRNOT00000023569 0.13 7.50E-06 Vkorc1l1 NM_001008334 0.16 9.63E-16 Vldlr CA945807 0.04 0.05 Vps13a NM_001024883 -0.09 0.02 Vps18 NM_181086 0.17 3.48E-06 Vps26a NM_013091 0.13 0.02 Vps33b NM_181384 0.1 0.03 Vps36 NM_201420 0.14 3.17E-03 Vps37b ENSRNOT00000020135 -0.1 2.71E-03 Vps45 ENSRNOT00000056860 0.07 0.05 Vps4a XM_001080123 0.11 0.01 Vps53 XM_001079613 0.06 0.03 Diabetes Page 178 of 288

Vps54 NM_133317 0.09 1.55E-03 Vps72 ENSRNOT00000014002 -0.09 7.58E-03 Vrk2 NM_212514 0.04 0.04 Vsnl1 NM_001044244 0.06 0.01 Vta1 NM_212520 0.09 1.45E-03 Wbp1 NM_001083338 0.11 0.04 Wbp11 NM_212519 0.07 2.86E-03 Wbscr18 BE115617 0.08 0.01 Wdfy1 ENSRNOT00000004698 -0.08 0.01 Wdr21 NM_001011906 -0.05 0.03 Wdr33 NM_145092 0.08 1.44E-03 Wdr45 ENSRNOT00000013975 -0.09 8.65E-03 Wdr53 NM_199100 0.11 0.02 Wdr55 NM_001009683 0.16 5.75E-04 Wdr61 NM_139332 0.19 7.07E-04 Wdr74 704155427J1 0.07 1.42E-04 Wdr91 NM_012686 0.12 9.12E-03 Wdsof1 NM_173111 0.06 0.02 Wfdc2 NM_001079531 0.09 3.11E-03 Whsc1l1 ENSRNOT00000060097 -0.09 1.96E-03 Wif1 NM_001025419 -0.07 0.01 Wipi2 NM_001009639 0.11 1.86E-04 Wnt4 ENSRNOT00000010906 0.11 0.01 Wrb CO404930 -0.12 6.27E-03 Wsb2 ENSRNOT00000052289 0.13 4.90E-06 Xkr6 ENSRNOT00000011002 -0.12 7.46E-03 Xkr8 ENSRNOT00000013030 0.08 0.02 Xpa XM_001060072 -0.12 0.01 Xpnpep1 NM_001039001 0.06 0.01 Xpnpep2 NM_001008376 0.07 4.10E-05 Xpo4 NM_013046 0.09 0.05 Xpot ENSRNOT00000023202 -0.08 0.02 Xpr1 ENSRNOT00000061558 0.1 0.02 Yipf1 ENSRNOT00000056206 0.08 0.05 Yipf5 ENSRNOT00000011876 0.05 0.03 Ykt6 ENSRNOT00000010691 0.14 1.09E-03 Ypel4 NM_001025284 -0.1 1.67E-04 Ypel5 NM_001025035 -0.1 6.00E-03 Ythdf1 NM_207608 0.31 5.63E-03 Ywhag NM_019376 -0.12 3.75E-04 Ywhaq NM_022638 0.11 0.03 Ywhaz AF090997 0.14 0.02 Zbtb1 ENSRNOT00000008489 -0.11 8.22E-06 Zbtb3 AI709650 -0.05 0.02 Zbtb44 L14323 -0.12 4.60E-03 Zc3h15 ENSRNOT00000038279 0.08 8.85E-03 Zc3h6 CB545346 -0.12 3.39E-04 Page 179 of 288 Diabetes

Zcchc11 XM_001060286 -0.13 1.14E-04 Zcchc8 NM_001024262 0.1 0.03 Zcrb1 NM_001013244 0.05 0.01 Zdhhc12 BG372856 0.15 0.05 Zdhhc13 NM_001005547 0.04 0.04 Zdhhc16 EB477013 0.07 0.02 Zdhhc20 ENSRNOT00000035875 -0.08 8.62E-03 Zdhhc3 EV766928 0.05 0.03 Zdhhc5 NM_001013033 0.03 0.03 Zdhhc6 NM_001034148 -0.09 0.04 Zeb2 BF415891 0.09 0.04 Zfand1 ENSRNOT00000004504 0.13 9.62E-04 Zfp189 XM_001076736 -0.1 2.04E-07 Zfp238 BP496038 -0.12 6.53E-03 Zfp259 NM_001012075 0.1 1.80E-03 Zfp364 ENSRNOT00000012306 0.06 0.02 Zfp386 ENSRNOT00000025548 0.07 0.01 Zfp438 NM_001024885 -0.1 5.96E-06 Zfp445 ENSRNOT00000015192 0.09 3.08E-03 Zfp472 XM_001062174 0.1 0.03 Zfp511 NM_017039 -0.05 9.95E-04 Zfp53 NM_001011995 0.11 1.20E-05 Zfp593 702079660H1 0.1 3.89E-03 Zfp622 NM_001025675 0.13 1.41E-03 Zfp644 ENSRNOT00000002882 -0.12 2.15E-04 Zfp667 ENSRNOT00000056437 0.12 4.64E-05 Zfp689 NM_001008324 -0.05 0.04 Zfp703 ENSRNOT00000030683 0.12 1.62E-03 Zfp90 NM_001004446 -0.07 2.87E-03 Zfp91 NM_053331 0.05 0.03 Zgpat AI137446 -0.08 0.03 Zmym2 NM_198778 -0.1 1.53E-03 Zmym6 ENSRNOT00000019574 0.06 0.05 Znrf1 CO572063 -0.11 4.93E-04 Zswim3 NM_031690 -0.08 0.03 Zswim6 ENSRNOT00000024573 -0.07 0.01 Zw10 NM_001014127 0.1 0.02 Zyg11b ENSRNOT00000017373 0.1 0.03 Zzef1 NM_001009669 0.09 2.85E-03 EV779074 0.12 2.90E-04 ENSRNOT00000009894 -0.12 0.02 NM_053507 -0.12 0.02 ENSRNOT00000008375 -0.12 0.02 AY724487 -0.12 0.02 ENSRNOT00000013957 -0.12 0.02 BF406274 -0.12 0.03 BI298352 -0.12 0.03 Diabetes Page 180 of 288

NM_001002802 -0.12 0.03 NM_133606 -0.12 0.03 NM_001030026 -0.12 0.03 NM_178091 -0.12 0.03 NM_001034946 -0.12 0.03 NM_138520 -0.12 0.03 g3730218 -0.12 0.03 XM_001063873 -0.12 0.03 NM_133552 -0.12 0.03 NM_012521 -0.12 0.03 NM_201350 -0.12 0.03 NM_053738 -0.12 0.03 XM_001073593 -0.12 0.03 ENSRNOT00000044481 -0.12 0.04 CK226272 -0.12 0.04 g14960812 -0.12 0.04 ENSRNOT00000001298 -0.12 0.04 NM_012828 -0.12 0.05 NM_175708 -0.12 0.05 g14960432 -0.12 0.05 ENSRNOT00000036321 -0.12 0.05 NM_199379 -0.13 4.54E-17 CO574703 -0.13 3.64E-12 ENSRNOT00000001924 -0.13 1.45E-08 NM_153306 -0.13 2.32E-08 NM_001001514 -0.13 7.36E-08 EV778024 -0.13 9.46E-08 BP469376 -0.13 1.39E-07 NM_001025022 -0.13 1.65E-07 ENSRNOT00000019157 -0.13 2.51E-07 AY724496 -0.13 6.84E-07 ENSRNOT00000011320 -0.13 7.25E-07 NM_001009651 -0.13 1.84E-06 ENSRNOT00000000891 -0.13 2.16E-06 ENSRNOT00000020750 -0.13 2.25E-06 CO554226 -0.13 3.49E-06 XM_001054328 -0.13 9.02E-06 NM_001013234 -0.13 1.52E-05 NM_001025287 -0.13 2.29E-05 ENSRNOT00000034723 -0.13 2.99E-05 XM_343297 -0.13 4.15E-05 NM_001048184 -0.13 4.85E-05 NM_031730 -0.13 5.22E-05 NM_001015004 -0.13 7.87E-05 ENSRNOT00000027550 -0.13 8.52E-05 ENSRNOT00000027726 -0.13 9.68E-05 NM_001012173 -0.13 1.18E-04 Page 181 of 288 Diabetes

NM_057118 -0.13 1.58E-04 ENSRNOT00000038946 -0.13 1.91E-04 ENSRNOT00000021140 -0.13 2.00E-04 BC100655 -0.13 2.22E-04 ENSRNOT00000030914 -0.13 3.12E-04 NM_001024246 -0.13 3.17E-04 EV764196 -0.13 4.04E-04 NM_053617 -0.13 5.29E-04 NM_001024765 -0.13 6.16E-04 ENSRNOT00000002465 -0.13 6.21E-04 NM_022956 -0.13 6.29E-04 XM_001081488 -0.13 7.57E-04 NM_001025650 -0.13 7.94E-04 AY623033 -0.13 8.20E-04 NM_001037770 -0.13 9.15E-04 ENSRNOT00000017901 -0.13 1.12E-03 NM_178093 -0.13 1.20E-03 D31854 -0.13 1.21E-03 NM_031613 -0.13 1.51E-03 NM_153467 -0.13 1.56E-03 ENSRNOT00000015474 -0.13 1.62E-03 NM_181388 -0.13 1.64E-03 NM_001007620 -0.13 1.71E-03 ENSRNOT00000016958 -0.13 1.87E-03 NM_001015020 -0.13 1.95E-03 AY089719 -0.13 1.98E-03 ENSRNOT00000021735 -0.13 2.59E-03 NM_130433 -0.13 2.66E-03 XM_001076211 -0.13 2.67E-03 ENSRNOT00000054875 -0.13 2.99E-03 BE104842 -0.13 2.99E-03 ENSRNOT00000022486 -0.13 4.31E-03 ENSRNOT00000015997 -0.13 4.94E-03 NM_012645 -0.13 6.96E-03 NM_181090 -0.13 7.18E-03 ENSRNOT00000056644 -0.13 7.89E-03 ENSRNOT00000012124 -0.13 8.51E-03 NM_001012111 -0.13 8.68E-03 NM_001039004 -0.13 8.76E-03 ENSRNOT00000020529 -0.13 8.88E-03 ENSRNOT00000006323 -0.13 9.26E-03 ENSRNOT00000014361 -0.13 9.55E-03 NM_001033894 -0.13 9.74E-03 CO384193 -0.13 9.93E-03 NM_012925 -0.13 0.01 NM_001012459 -0.13 0.01 NM_173312 -0.13 0.01 Diabetes Page 182 of 288

NM_133603 -0.13 0.01 ENSRNOT00000006131 -0.13 0.01 CX570281 -0.13 0.01 NM_001039336 -0.13 0.01 NM_022863 -0.13 0.02 AW533028 -0.13 0.02 CB326419 -0.13 0.02 XM_001078860 -0.13 0.02 ENSRNOT00000023601 -0.13 0.02 ENSRNOT00000020757 -0.13 0.02 NM_001009704 -0.13 0.02 ENSRNOT00000000427 -0.13 0.02 ENSRNOT00000026458 -0.13 0.02 ENSRNOT00000039524 -0.13 0.02 ENSRNOT00000022637 -0.13 0.02 NM_017244 -0.13 0.03 XM_226987 -0.13 0.03 NM_001013120 -0.13 0.03 NM_032062 -0.13 0.03 XM_578409 -0.13 0.03 NM_001011982 -0.13 0.03 ENSRNOT00000021750 -0.13 0.03 ENSRNOT00000035085 -0.13 0.03 NM_023096 -0.13 0.04 NM_001015017 -0.13 0.04 XM_344571 -0.13 0.05 NM_012796 -0.13 0.05 ENSRNOT00000057423 -0.13 0.05 NM_134363 -0.13 0.05 NM_181626 -0.14 1.60E-11 NM_017359 -0.14 1.19E-10 NM_001012010 -0.14 4.44E-08 ENSRNOT00000008948 -0.14 1.40E-07 NM_001013963 -0.14 1.49E-07 NM_053756 -0.14 1.55E-07 NM_053729 -0.14 2.37E-07 NM_001014085 -0.14 3.90E-07 BC078778 -0.14 8.08E-07 NM_001008331 -0.14 1.15E-06 AW527566 -0.14 1.64E-06 NM_013065 -0.14 5.19E-06 NM_017015 -0.14 6.43E-06 AF056002 -0.14 8.11E-06 NM_001008372 -0.14 9.68E-06 NM_053618 -0.14 1.11E-05 NM_175765 -0.14 1.14E-05 NM_001044248 -0.14 1.46E-05 Page 183 of 288 Diabetes

DV719825 -0.14 1.86E-05 NM_032080 -0.14 1.95E-05 NM_001009655 -0.14 2.30E-05 ENSRNOT00000038144 -0.14 3.77E-05 NM_001011941 -0.14 4.16E-05 NM_001017503 -0.14 4.24E-05 NM_152849 -0.14 4.72E-05 NM_001024747 -0.14 5.71E-05 BC091392 -0.14 6.75E-05 ENSRNOT00000021052 -0.14 8.07E-05 NM_198731 -0.14 1.25E-04 XM_217208 -0.14 1.25E-04 ENSRNOT00000003871 -0.14 1.97E-04 CK228000 -0.14 2.23E-04 NM_001024868 -0.14 3.07E-04 NM_001004270 -0.14 3.07E-04 ENSRNOT00000008034 -0.14 3.16E-04 ENSRNOT00000007927 -0.14 3.53E-04 L19181 -0.14 4.44E-04 NM_001009656 -0.14 8.55E-04 NM_030999 -0.14 1.00E-03 NM_001013155 -0.14 1.10E-03 NM_017268 -0.14 1.13E-03 ENSRNOT00000047417 -0.14 1.26E-03 NM_130421 -0.14 1.32E-03 NM_138896 -0.14 1.58E-03 NM_001037180 -0.14 2.55E-03 ENSRNOT00000027054 -0.14 2.55E-03 g8494950 -0.14 2.59E-03 ENSRNOT00000036656 -0.14 2.78E-03 NM_012919 -0.14 3.02E-03 NM_001013077 -0.14 3.97E-03 ENSRNOT00000032822 -0.14 4.82E-03 NM_001004418 -0.14 5.15E-03 ENSRNOT00000021189 -0.14 8.47E-03 AI710662 -0.14 8.60E-03 ENSRNOT00000016400 -0.14 8.65E-03 ENSRNOT00000028178 -0.14 9.74E-03 BP488642 -0.14 9.88E-03 ENSRNOT00000031337 -0.14 0.01 BE103925 -0.14 0.02 ENSRNOT00000035580 -0.14 0.02 ENSRNOT00000017624 -0.14 0.02 NM_053456 -0.14 0.02 XM_576413 -0.14 0.02 DV713856 -0.14 0.02 ENSRNOT00000013385 -0.14 0.02 Diabetes Page 184 of 288

NM_019303 -0.14 0.04 NM_001013036 -0.14 0.04 M64698 -0.14 0.04 NM_001014053 -0.14 0.04 ENSRNOT00000012616 -0.15 1.34E-24 NM_053605 -0.15 2.40E-14 NM_031354 -0.15 1.79E-11 NM_001079887 -0.15 2.00E-11 NM_001024785 -0.15 2.42E-10 NM_001007702 -0.15 5.09E-10 XM_001079065 -0.15 5.30E-10 BF550674 -0.15 9.12E-10 ENSRNOT00000017204 -0.15 1.27E-09 CO402386 -0.15 5.88E-09 BQ782539 -0.15 6.82E-09 ENSRNOT00000059807 -0.15 7.71E-09 CV797035 -0.15 2.70E-08 NM_001031660 -0.15 5.98E-08 ENSRNOT00000007549 -0.15 6.28E-08 g4136221 -0.15 1.92E-07 CK838765 -0.15 4.32E-07 NM_001024789 -0.15 1.66E-06 ENSRNOT00000057978 -0.15 2.99E-06 ENSRNOT00000017252 -0.15 3.97E-06 ENSRNOT00000012214 -0.15 5.90E-06 NM_001013901 -0.15 6.03E-06 ENSRNOT00000039176 -0.15 1.31E-05 NM_147205 -0.15 2.50E-05 704149177J1 -0.15 3.18E-05 BP465715 -0.15 3.99E-05 AW526523 -0.15 4.29E-05 BC100146 -0.15 6.99E-05 NM_012894 -0.15 9.44E-05 NM_021739 -0.15 1.35E-04 ENSRNOT00000005645 -0.15 1.42E-04 ENSRNOT00000033307 -0.15 1.70E-04 ENSRNOT00000017809 -0.15 2.15E-04 CO574092 -0.15 2.94E-04 ENSRNOT00000028052 -0.15 4.60E-04 ENSRNOT00000042495 -0.15 4.63E-04 BF408712 -0.15 4.87E-04 ENSRNOT00000013983 -0.15 6.76E-04 NM_031002 -0.15 1.19E-03 ENSRNOT00000020673 -0.15 1.25E-03 XM_001058651 -0.15 1.39E-03 ENSRNOT00000002727 -0.15 1.44E-03 NM_053951 -0.15 1.47E-03 Page 185 of 288 Diabetes

ENSRNOT00000010932 -0.15 1.86E-03 ENSRNOT00000015526 -0.15 2.56E-03 ENSRNOT00000028625 -0.15 2.61E-03 NM_152844 -0.15 2.83E-03 NM_001013958 -0.15 4.37E-03 ENSRNOT00000026883 -0.15 5.36E-03 AW534218 -0.15 5.69E-03 NM_023975 -0.15 6.32E-03 ENSRNOT00000000022 -0.15 6.36E-03 CV108587 -0.15 8.20E-03 BF406663 -0.15 8.60E-03 NM_012619 -0.15 9.41E-03 g11402087 -0.15 0.01 NM_139089 -0.15 0.01 ENSRNOT00000039225 -0.15 0.01 NM_030989 -0.15 0.01 CA503947 -0.15 0.01 AY903248 -0.15 0.02 NM_031235 -0.15 0.02 ENSRNOT00000002984 -0.15 0.02 NM_031841 -0.15 0.02 NM_001034129 -0.15 0.02 ENSRNOT00000058434 -0.15 0.03 NM_001014192 -0.15 0.03 NM_013045 -0.15 0.03 NM_017034 -0.15 0.04 NM_001042621 -0.15 0.04 ENSRNOT00000012721 -0.15 0.04 NM_001012116 -0.15 0.04 ENSRNOT00000034133 -0.15 0.04 XM_001072364 -0.16 3.36E-17 ENSRNOT00000004093 -0.16 7.35E-17 NM_175604 -0.16 1.87E-13 AW913871 -0.16 6.47E-09 ENSRNOT00000019368 -0.16 6.88E-08 ENSRNOT00000013560 -0.16 2.11E-07 NM_177425 -0.16 9.23E-07 XM_001061827 -0.16 1.09E-06 XM_001060279 -0.16 1.36E-06 ENSRNOT00000016428 -0.16 2.34E-06 NM_001035255 -0.16 3.39E-06 ENSRNOT00000019680 -0.16 5.57E-06 ENSRNOT00000018495 -0.16 6.09E-06 ENSRNOT00000010211 -0.16 4.11E-05 ENSRNOT00000021136 -0.16 5.99E-05 ENSRNOT00000000898 -0.16 7.35E-05 NM_001024342 -0.16 8.18E-05 Diabetes Page 186 of 288

NM_001005563 -0.16 9.35E-05 NM_053539 -0.16 1.96E-04 ENSRNOT00000005882 -0.16 3.81E-04 NM_017361 -0.16 4.20E-04 XM_221962 -0.16 5.28E-04 ENSRNOT00000048933 -0.16 5.78E-04 NM_031515 -0.16 6.23E-04 NM_053637 -0.16 6.65E-04 NM_012591 -0.16 7.74E-04 NM_001014233 -0.16 9.27E-04 XM_229201 -0.16 1.26E-03 AI136424 -0.16 1.70E-03 NM_013160 -0.16 1.70E-03 CF115472 -0.16 4.44E-03 NM_001037648 -0.16 5.27E-03 XM_573539 -0.16 5.48E-03 ENSRNOT00000040909 -0.16 5.66E-03 NM_012914 -0.16 5.69E-03 CA507027 -0.16 6.31E-03 NM_001039013 -0.16 6.68E-03 NM_144730 -0.16 9.52E-03 NM_133318 -0.16 9.76E-03 ENSRNOT00000042204 -0.16 0.01 BP465710 -0.16 0.01 g13270342 -0.16 0.02 NM_032990 -0.16 0.02 ENSRNOT00000008911 -0.16 0.02 NM_012751 -0.16 0.02 ENSRNOT00000026168 -0.17 2.23E-20 BC079464 -0.17 3.10E-14 700371222F6 -0.17 5.32E-12 NM_001006997 -0.17 2.93E-11 703124629T1 -0.17 1.04E-10 DQ480749 -0.17 5.82E-10 NM_001034011 -0.17 6.79E-08 ENSRNOT00000020780 -0.17 7.61E-08 NM_182825 -0.17 4.25E-07 704232218H1 -0.17 1.31E-06 NM_053845 -0.17 1.70E-06 NM_001037652 -0.17 3.32E-06 ENSRNOT00000061677 -0.17 7.42E-06 ENSRNOT00000016939 -0.17 1.02E-05 NM_001033891 -0.17 2.17E-05 ENSRNOT00000003494 -0.17 3.32E-05 NM_001024774 -0.17 3.38E-05 BF287829 -0.17 4.53E-05 NM_031134 -0.17 6.27E-05 Page 187 of 288 Diabetes

NM_001013859 -0.17 1.55E-04 ENSRNOT00000024458 -0.17 1.64E-04 NM_001009654 -0.17 1.87E-04 NM_001005902 -0.17 2.06E-04 ENSRNOT00000013781 -0.17 2.50E-04 NM_031344 -0.17 7.30E-04 BU759240 -0.17 1.15E-03 NM_130401 -0.17 1.24E-03 NM_001017470 -0.17 1.34E-03 NM_012685 -0.17 1.58E-03 NM_001013221 -0.17 2.13E-03 ENSRNOT00000009584 -0.17 2.90E-03 NM_017317 -0.17 2.96E-03 ENSRNOT00000049855 -0.17 3.14E-03 XM_231528 -0.17 3.37E-03 DY472844 -0.17 3.54E-03 NM_012831 -0.17 4.68E-03 ENSRNOT00000033827 -0.17 4.87E-03 ENSRNOT00000008104 -0.17 5.92E-03 ENSRNOT00000045280 -0.17 6.39E-03 ENSRNOT00000019524 -0.17 7.92E-03 ENSRNOT00000014812 -0.17 8.34E-03 NM_130735 -0.17 8.70E-03 DY472259 -0.17 0.01 NM_058208 -0.17 0.01 NM_001024369 -0.17 0.01 NM_172092 -0.17 0.02 ENSRNOT00000021744 -0.17 0.02 NM_053669 -0.17 0.04 XM_001081346 -0.18 5.56E-19 ENSRNOT00000001229 -0.18 5.68E-19 ENSRNOT00000016051 -0.18 1.34E-16 ENSRNOT00000045519 -0.18 3.66E-14 AY724528 -0.18 9.57E-13 NM_001004255 -0.18 4.09E-12 NM_001013914 -0.18 1.15E-11 NM_001013125 -0.18 5.44E-09 BC087711 -0.18 8.37E-09 NM_017079 -0.18 8.91E-08 NM_001013154 -0.18 9.65E-08 ENSRNOT00000005978 -0.18 2.42E-07 ENSRNOT00000013359 -0.18 3.39E-07 DV713693 -0.18 3.05E-06 ENSRNOT00000017866 -0.18 6.45E-06 NM_022685 -0.18 7.05E-06 ENSRNOT00000009438 -0.18 7.49E-06 NM_139060 -0.18 9.95E-06 Diabetes Page 188 of 288

NM_053718 -0.18 1.13E-05 NM_031334 -0.18 2.21E-04 BF416524 -0.18 2.70E-04 ENSRNOT00000014373 -0.18 3.16E-04 703895489J1 -0.18 3.82E-04 ENSRNOT00000001445 -0.18 6.45E-04 NM_001002279 -0.18 8.82E-04 NM_013221 -0.18 9.99E-04 NM_012821 -0.18 1.05E-03 NM_001033674 -0.18 1.09E-03 NM_053945 -0.18 1.17E-03 ENSRNOT00000020763 -0.18 1.18E-03 NM_001035221 -0.18 1.23E-03 ENSRNOT00000024149 -0.18 1.55E-03 ENSRNOT00000033788 -0.18 4.37E-03 NM_134467 -0.18 9.31E-03 703911795J1 -0.18 9.71E-03 NM_139111 -0.18 0.01 ENSRNOT00000002119 -0.18 0.01 AY045577 -0.18 0.02 ENSRNOT00000007303 -0.18 0.02 NM_001077589 -0.18 0.02 NM_001039024 -0.18 0.04 NM_053323 -0.19 1.03E-15 BC098826 -0.19 6.50E-14 NM_053522 -0.19 1.32E-12 NM_001014111 -0.19 7.59E-12 ENSRNOT00000015786 -0.19 2.84E-11 NM_054006 -0.19 4.40E-11 NM_001014055 -0.19 8.85E-10 ENSRNOT00000014028 -0.19 1.35E-09 NM_001014176 -0.19 1.67E-09 NM_001034941 -0.19 9.74E-07 ENSRNOT00000012131 -0.19 1.05E-06 NM_053463 -0.19 1.36E-06 NM_024390 -0.19 2.94E-06 NM_001009601 -0.19 3.82E-06 NM_022601 -0.19 6.61E-06 ENSRNOT00000019089 -0.19 6.83E-06 ENSRNOT00000002918 -0.19 7.00E-06 NM_019623 -0.19 9.36E-06 ENSRNOT00000010714 -0.19 1.35E-05 NM_012650 -0.19 2.61E-05 NM_133395 -0.19 1.07E-04 NM_173308 -0.19 2.22E-04 CN543861 -0.19 2.74E-04 CK845370 -0.19 3.84E-04 Page 189 of 288 Diabetes

NM_053577 -0.19 4.58E-04 BC090015 -0.19 5.33E-04 ENSRNOT00000027558 -0.19 6.17E-04 NM_138710 -0.19 1.02E-03 NM_206849 -0.19 1.21E-03 NM_017326 -0.19 1.78E-03 ENSRNOT00000023169 -0.19 2.45E-03 NM_001079938 -0.19 2.51E-03 NM_152242 -0.19 4.44E-03 NM_133421 -0.19 6.25E-03 CD372876 -0.19 7.19E-03 NM_019229 -0.19 7.55E-03 704319971J1 -0.19 7.74E-03 XM_575179 -0.19 8.41E-03 XM_226016 -0.19 9.18E-03 NM_023987 -0.19 0.02 ENSRNOT00000015897 -0.19 0.02 NM_001008336 -0.19 0.02 NM_078619 -0.19 0.03 NM_001033069 -0.19 0.05 CX569586 -0.2 3.98E-24 NM_001013131 -0.2 5.12E-24 NM_023104 -0.2 1.50E-15 ENSRNOT00000001772 -0.2 3.93E-09 ENSRNOT00000050656 -0.2 1.35E-08 ENSRNOT00000055028 -0.2 2.23E-08 AB043638 -0.2 2.98E-08 NM_172019 -0.2 3.18E-08 NM_001047854 -0.2 8.61E-08 NM_017166 -0.2 4.42E-07 702082415F6 -0.2 7.14E-07 ENSRNOT00000008281 -0.2 4.85E-06 ENSRNOT00000012396 -0.2 5.62E-06 ENSRNOT00000000750 -0.2 6.34E-06 XM_215057 -0.2 2.21E-05 NM_054011 -0.2 4.30E-05 ENSRNOT00000004883 -0.2 6.17E-05 NM_024137 -0.2 7.75E-05 NM_001008517 -0.2 1.06E-04 NM_053644 -0.2 1.15E-04 DQ282125 -0.2 1.76E-04 NM_031686 -0.2 2.96E-04 ENSRNOT00000008692 -0.2 4.55E-04 NM_012897 -0.2 8.68E-04 ENSRNOT00000006454 -0.2 1.02E-03 g18190501 -0.2 1.34E-03 ENSRNOT00000006151 -0.2 1.60E-03 Diabetes Page 190 of 288

BF406923 -0.2 2.67E-03 703861224J1 -0.2 2.88E-03 NM_133558 -0.2 3.31E-03 XM_001070433 -0.2 4.54E-03 NM_022267 -0.2 0.04 ENSRNOT00000038720 -0.2 0.05 BQ782172 -0.21 5.44E-25 NM_001038495 -0.21 8.16E-15 NM_022248 -0.21 8.25E-15 NM_001037792 -0.21 6.84E-14 NM_001007796 -0.21 3.00E-13 EV776653 -0.21 5.44E-13 NM_022265 -0.21 1.19E-12 NM_001007665 -0.21 1.78E-11 NM_001014122 -0.21 2.17E-11 NM_001004230 -0.21 1.47E-10 ENSRNOT00000001941 -0.21 1.52E-09 DV718956 -0.21 2.46E-07 ENSRNOT00000021739 -0.21 4.73E-07 ENSRNOT00000003667 -0.21 5.40E-07 XM_001056316 -0.21 7.33E-07 NM_001014212 -0.21 1.16E-06 DV718637 -0.21 1.76E-06 ENSRNOT00000026379 -0.21 5.21E-06 DV727600 -0.21 9.71E-06 ENSRNOT00000010303 -0.21 3.16E-05 XM_001068287 -0.21 6.59E-05 NM_212463 -0.21 1.25E-04 ENSRNOT00000032535 -0.21 1.45E-04 ENSRNOT00000013955 -0.21 1.59E-04 ENSRNOT00000002356 -0.21 2.00E-04 NM_053611 -0.21 3.44E-04 XM_001053896 -0.21 3.97E-04 NM_013144 -0.21 4.85E-04 DN936121 -0.21 6.35E-04 DW395452 -0.21 7.19E-04 NM_001004444 -0.21 1.74E-03 CN541495 -0.21 2.48E-03 NM_199093 -0.21 4.30E-03 NM_031967 -0.21 4.41E-03 ENSRNOT00000023506 -0.21 0.04 NM_053299 -0.21 0.04 NM_001012470 -0.21 0.05 XM_575014 -0.22 3.08E-14 ENSRNOT00000041380 -0.22 2.57E-10 XM_001062918 -0.22 3.24E-10 CF110567 -0.22 8.41E-10 Page 191 of 288 Diabetes

NM_053343 -0.22 2.30E-09 ENSRNOT00000012354 -0.22 9.34E-09 BC081731 -0.22 1.24E-06 ENSRNOT00000018021 -0.22 2.78E-06 NM_001033693 -0.22 3.08E-06 ENSRNOT00000015668 -0.22 6.73E-05 ENSRNOT00000028381 -0.22 3.63E-04 CK843962 -0.22 4.14E-04 XM_001063422 -0.22 7.61E-04 ENSRNOT00000022861 -0.22 1.14E-03 ENSRNOT00000051594 -0.22 1.34E-03 BP503917 -0.22 1.37E-03 ENSRNOT00000045052 -0.22 1.88E-03 NM_001014088 -0.22 1.89E-03 ENSRNOT00000028186 -0.22 9.20E-03 NM_053715 -0.22 0.01 NM_001012086 -0.22 0.02 ENSRNOT00000020925 -0.22 0.03 NM_001037789 -0.22 0.04 NM_021852 -0.23 4.64E-29 ENSRNOT00000011017 -0.23 1.10E-20 NM_001007697 -0.23 2.22E-15 NM_057140 -0.23 3.68E-14 NM_031774 -0.23 9.63E-12 ENSRNOT00000044177 -0.23 4.10E-11 ENSRNOT00000031974 -0.23 3.64E-10 CF975977 -0.23 1.19E-09 NM_022278 -0.23 8.78E-09 NM_053910 -0.23 2.65E-08 ENSRNOT00000022214 -0.23 1.65E-07 NM_001007692 -0.23 9.47E-06 NM_030872 -0.23 1.88E-05 NM_031135 -0.23 5.07E-05 NM_031559 -0.23 1.06E-04 NM_001007001 -0.23 1.59E-04 XM_001061679 -0.23 1.70E-04 AM040230 -0.23 6.40E-04 NM_181629 -0.23 6.61E-04 ENSRNOT00000002692 -0.23 1.61E-03 NM_016996 -0.23 6.44E-03 g11373925 -0.23 0.01 NM_001017478 -0.23 0.04 NM_001034147 -0.24 3.57E-24 NM_001012194 -0.24 1.02E-16 NM_022674 -0.24 5.49E-11 ENSRNOT00000008119 -0.24 1.18E-10 ENSRNOT00000023456 -0.24 4.27E-10 Diabetes Page 192 of 288

NM_199104 -0.24 9.08E-09 BQ193237 -0.24 5.46E-07 NM_182675 -0.24 9.22E-07 703885047J1 -0.24 7.28E-06 ENSRNOT00000028418 -0.24 8.02E-06 NM_023099 -0.24 2.08E-05 NM_001033682 -0.24 4.22E-05 NM_021859 -0.24 1.26E-04 ENSRNOT00000026539 -0.24 5.13E-04 NM_013129 -0.24 4.69E-03 ENSRNOT00000020823 -0.24 0.04 DV723221 -0.25 3.54E-27 ENSRNOT00000026567 -0.25 3.03E-22 BC089912 -0.25 1.36E-17 CA506965 -0.25 3.56E-13 g8082072 -0.25 5.79E-12 ENSRNOT00000009328 -0.25 3.46E-10 AI231309 -0.25 4.65E-10 702958101J1 -0.25 6.18E-08 ENSRNOT00000020889 -0.25 1.87E-07 ENSRNOT00000022649 -0.25 7.11E-07 ENSRNOT00000015044 -0.25 1.69E-06 NM_020097 -0.25 3.58E-06 702955022H1 -0.25 6.85E-06 ENSRNOT00000048264 -0.25 1.11E-05 ENSRNOT00000017607 -0.25 4.38E-05 ENSRNOT00000024023 -0.25 7.72E-05 ENSRNOT00000008990 -0.25 1.57E-04 NM_030839 -0.25 5.16E-04 ENSRNOT00000061446 -0.25 7.76E-04 NM_001039609 -0.25 5.97E-03 NM_001009663 -0.25 0.02 NM_053359 -0.26 1.55E-28 NM_001039197 -0.26 4.35E-15 XM_001062342 -0.26 2.67E-14 CO571802 -0.26 1.53E-13 NM_001014140 -0.26 9.63E-07 ENSRNOT00000008940 -0.26 1.30E-06 ENSRNOT00000057001 -0.26 1.38E-06 CA506321 -0.26 4.78E-05 ENSRNOT00000021359 -0.26 1.27E-04 NM_031982 -0.26 1.38E-04 NM_173114 -0.26 4.59E-04 NM_153814 -0.26 5.23E-03 BC089927 -0.27 2.47E-33 NM_057213 -0.27 9.89E-31 ENSRNOT00000004192 -0.27 9.49E-30 Page 193 of 288 Diabetes

704240832J1 -0.27 1.53E-19 NM_001025697 -0.27 3.17E-15 ENSRNOT00000025008 -0.27 4.96E-13 AA946404 -0.27 4.11E-12 BM388706 -0.27 6.36E-11 ENSRNOT00000050686 -0.27 3.01E-09 ENSRNOT00000038543 -0.27 8.51E-09 g11659913 -0.27 3.40E-08 ENSRNOT00000005477 -0.27 3.23E-07 DV725908 -0.27 7.22E-07 NM_022264 -0.27 2.63E-05 NM_001005883 -0.27 7.16E-05 NM_023991 -0.27 2.15E-04 NM_001011985 -0.27 4.90E-04 ENSRNOT00000007028 -0.27 8.29E-04 NM_001013162 -0.27 2.27E-03 XM_342445 -0.27 3.92E-03 ENSRNOT00000014537 -0.27 0.02 NM_022243 -0.28 0 NM_017148 -0.28 1.52E-19 XM_342154 -0.28 3.09E-17 ENSRNOT00000060789 -0.28 1.41E-16 NM_053796 -0.28 1.65E-11 ENSRNOT00000022963 -0.28 1.18E-08 NM_173143 -0.28 1.99E-07 ENSRNOT00000010555 -0.28 7.83E-04 ENSRNOT00000017833 -0.28 1.01E-03 CB766061 -0.28 3.42E-03 NM_001009539 -0.29 6.73E-33 CO574727 -0.29 7.12E-23 NM_001034919 -0.29 2.77E-12 DY315267 -0.29 1.44E-11 NM_001012033 -0.29 3.16E-11 NM_001039665 -0.29 9.79E-11 NM_031740 -0.29 2.75E-08 NM_031836 -0.29 5.25E-08 NM_138912 -0.29 2.44E-06 NM_057135 -0.29 2.22E-05 NM_017007 -0.29 2.29E-03 NM_017024 -0.29 0.02 ENSRNOT00000021549 -0.29 0.03 NM_001014141 -0.3 2.54E-33 NM_019296 -0.3 4.33E-23 NM_031755 -0.3 2.72E-20 703206608J1 -0.3 1.80E-15 NM_178096 -0.3 4.74E-10 ENSRNOT00000023497 -0.3 7.42E-09 Diabetes Page 194 of 288

NM_013042 -0.3 1.82E-06 NM_001003929 -0.3 0.03 NM_001009536 -0.31 6.79E-30 ENSRNOT00000035905 -0.31 4.05E-09 ENSRNOT00000044527 -0.31 7.05E-09 NM_173322 -0.31 1.05E-07 NM_057210 -0.31 2.83E-05 NM_176861 -0.31 7.68E-04 703868363J1 -0.31 1.15E-03 NM_031652 -0.31 5.95E-03 ENSRNOT00000035373 -0.31 0.02 CF110967 -0.32 7.55E-40 NM_031147 -0.32 7.31E-37 BC081988 -0.32 4.05E-29 ENSRNOT00000011456 -0.32 3.73E-22 BE099049 -0.32 1.13E-16 NM_031345 -0.32 1.39E-11 ENSRNOT00000061234 -0.32 1.69E-11 NM_053878 -0.32 2.16E-07 ENSRNOT00000032861 -0.32 9.77E-06 NM_012856 -0.32 6.48E-03 NM_032079 -0.33 0 ENSRNOT00000051335 -0.33 1.68E-22 NM_001009349 -0.33 5.87E-14 NM_053455 -0.33 7.33E-07 704274088J1 -0.33 1.33E-05 NM_001008767 -0.33 4.02E-05 ENSRNOT00000013738 -0.34 0 NM_001017458 -0.34 2.28E-13 704227082H1 -0.34 2.93E-10 NM_001034942 -0.34 2.37E-07 NM_001006968 -0.35 2.34E-33 NM_001025034 -0.35 5.94E-14 NM_182952 -0.35 1.25E-08 BU758540 -0.35 4.57E-07 ENSRNOT00000009759 -0.35 2.30E-05 M37828 -0.35 0.03 ENSRNOT00000002397 -0.36 2.00E-24 ENSRNOT00000004558 -0.36 1.30E-16 NM_021762 -0.36 1.92E-12 BQ193891 -0.36 1.30E-07 NM_001012072 -0.36 6.08E-03 XM_230015 -0.37 1.93E-24 XM_573923 -0.37 4.84E-22 704298950J1 -0.37 1.54E-17 NM_001037654 -0.37 9.13E-12 NM_017067 -0.37 4.35E-05 Page 195 of 288 Diabetes

ENSRNOT00000024450 -0.38 3.26E-29 NM_181473 -0.38 2.64E-20 NM_031614 -0.38 3.18E-20 NM_053352 -0.38 2.12E-14 NM_001014001 -0.39 0 ENSRNOT00000043907 -0.39 6.91E-23 ENSRNOT00000007492 -0.39 1.52E-05 NM_138900 -0.39 0.04 BP502793 -0.39 0.05 NM_053530 -0.4 8.19E-41 ENSRNOT00000013356 -0.4 2.89E-20 NM_133620 -0.4 5.40E-14 702598971T1 -0.4 3.25E-04 AB105879 -0.4 6.95E-04 NM_172045 -0.41 0 XM_001076791 -0.41 4.30E-25 NM_001037354 -0.41 1.44E-04 NM_001012042 -0.41 1.27E-03 ENSRNOT00000011395 -0.42 1.05E-17 NM_138871 -0.43 2.50E-26 NM_153304 -0.43 2.18E-11 NM_012760 -0.43 3.42E-03 NM_001025715 -0.44 1.96E-44 ENSRNOT00000012779 -0.44 6.03E-26 NM_001029919 -0.44 1.24E-16 NM_013057 -0.45 6.41E-17 ENSRNOT00000018650 -0.46 8.47E-25 NM_001005560 -0.46 3.24E-21 NM_138852 -0.46 2.92E-05 NM_175597 -0.47 0 NM_001009604 -0.47 1.16E-23 NM_178102 -0.49 1.06E-18 NM_001007737 -0.5 4.37E-18 ENSRNOT00000025592 -0.62 0 NM_001009632 -0.67 3.85E-08 X97831 -0.95 2.35E-42 CF111759 0.35 1.99E-03 Diabetes Page 196 of 288

mRNAs colored red contain seed region against both miRNA-132 and 212 Page 197 of 288 Diabetes

Gene Symbol Accession Number Log(Ratio) P-value March3 NM_001007759 0.33 1.87E-07 mRNAs colored red contain seed region against both miRNA-132 and 212 March5 XM_001080178 0.12 9.45E-09 March11 AB048841 0.15 9.94E-03 Sept2 NM_057148 0.06 0.01 Sept11 703880893J1 -0.14 3.03E-05 Sept12 ENSRNOT00000061208 -0.05 0.04 A3galt2 NM_138524 -0.12 2.37E-03 Aacs NM_023104 -0.25 1.39E-21 Aadat CR466784 -0.11 1.61E-03 Aamp ENSRNOT00000019497 -0.08 6.10E-06 Aasdh XM_344230 -0.09 0.01 Aasdhppt ENSRNOT00000008062 0.06 1.83E-04 Abcb6 NM_080582 0.1 0.05 Abcb7 NM_212518 0.19 3.99E-03 Abcb8 NM_001007796 -0.16 3.47E-14 Abcb9 NM_022238 0.18 4.13E-03 Abcc1 NM_022281 0.13 0.01 Abcc5 NM_053924 0.09 0.02 Abcc8 NM_013039 -0.13 0.04 Abce1 ENSRNOT00000024753 0.13 4.40E-05 Abcf1 CK359266 0.14 1.84E-04 Abcf2 ENSRNOT00000014718 0.07 8.88E-03 Abcg1 NM_053502 -0.13 6.72E-09 Abhd10 g8495343 0.15 2.15E-12 Abhd11 ENSRNOT00000025560 0.07 0.03 Abhd12 NM_001024314 0.13 1.83E-03 Abhd13 ENSRNOT00000019563 0.15 3.95E-06 Abhd3 ENSRNOT00000041878 0.11 2.82E-05 Abhd6 NM_001007680 0.11 2.38E-06 Abhd7 ENSRNOT00000037101 -0.12 0.03 Abi2 NM_173143 -0.17 4.11E-05 Abl1 ENSRNOT00000042495 -0.22 1.69E-06 Ablim3 XM_001058944 0.17 6.75E-04 Abo_predicted ENSRNOT00000061276 0.09 4.20E-04 Abr ENSRNOT00000032861 -0.25 4.98E-04 Abt1 ENSRNOT00000023649 0.11 4.93E-05 Abtb1 NM_001005902 -0.09 0.02 Acaa2 NM_130433 -0.14 2.47E-03 Acaca X53003 -0.15 3.75E-03 Acad11 ENSRNOT00000038383 0.1 0.02 Acad9 BF406274 -0.2 9.30E-05 Acadl NM_012819 -0.11 8.64E-03 Acadm NM_016986 0.1 3.81E-05 Acadsb NM_013084 0.19 2.50E-03 Accn2 AJ006519 0.06 0.05 Acd NM_001037193 0.15 2.36E-09 Diabetes Page 198 of 288

Acly EV776653 -0.22 1.61E-14 Aco1 NM_017321 0.08 1.00E-02 Aco2 AJ243266 0.08 3.85E-05 Acot3 ENSRNOT00000051235 0.1 4.89E-03 Acox1 ENSRNOT00000042372 0.09 1.02E-03 Acp2 NM_016988 0.09 1.75E-03 Acp6 NM_001031645 0.11 1.80E-03 Acsl4 NM_053623 -0.43 0 Acsl5 NM_053607 0.08 1.48E-03 Actb NM_031144 -0.07 1.46E-03 Actr10 NM_001009602 0.06 8.45E-03 Actr2 g8501150 -0.54 1.19E-38 Actr3 NM_031068 -0.17 1.22E-09 Actr3b ENSRNOT00000050686 -0.23 5.97E-09 Actr5 ENSRNOT00000041276 0.12 6.81E-04 Actr6 XM_001076791 -0.51 0 Actr8 ENSRNOT00000020750 -0.19 3.30E-14 Acvr2a NM_031571 0.06 1.66E-03 Acyp1 ENSRNOT00000009086 0.09 1.62E-03 Ada NM_130399 0.3 4.36E-06 Adam17 NM_020306 0.18 1.78E-06 Adam18 ENSRNOT00000023805 -0.14 0.03 Adam9 NM_001014772 0.09 4.95E-03 Adamts16 ENSRNOT00000022790 -0.12 1.18E-03 Adarb1 NM_012894 -0.13 1.91E-04 Adck2 ENSRNOT00000013277 0.08 1.30E-04 Adcy6 NM_012821 -0.21 1.00E-05 Adcy8 NM_017142 0.22 0.02 Add2 NM_012491 0.15 0.03 Adfp CO574727 -0.14 4.15E-15 Adh4 ENSRNOT00000017252 -0.17 2.75E-10 Adipor1 BQ208259 0.05 6.33E-03 Adipor2 ENSRNOT00000010556 -0.06 0.01 Adk NM_012895 0.09 0.01 Adnp NM_022681 -0.14 7.96E-03 Ado ENSRNOT00000000791 0.13 2.68E-07 Adpgk ENSRNOT00000013022 0.13 6.43E-05 Adrbk2 NM_012897 -0.15 4.44E-03 Afap1l1 ENSRNOT00000026495 0.07 5.27E-03 Afg3l1 ENSRNOT00000030399 0.08 0.05 Afg3l2 BC091419 0.07 1.60E-03 Afp NM_012493 -0.06 0.02 Agpat2 ENSRNOT00000026408 0.14 1.03E-04 Agpat3 703889388J1 0.19 4.37E-04 Agpat5 CX570492 0.08 0.01 Ahctf1 BF282038 -0.1 0.02 Ahcy NM_017201 -0.07 2.60E-03 Page 199 of 288 Diabetes

Ahnak EF076768 -0.1 0.03 Aifm1 NM_031356 0.12 3.03E-08 Aig1 AI231309 -0.25 2.55E-13 Ak3 NM_013218 -0.14 4.44E-03 Ak3l1 BC087024 0.3 1.26E-03 Akap10_predicted ENSRNOT00000003871 -0.14 6.82E-06 Akap8l BE102687 0.16 1.52E-05 Akt1s1 ENSRNOT00000027478 -0.09 0.02 Aldh1l2 g3291417 -0.39 2.41E-14 Alg10b NM_139101 0.13 4.10E-04 Alg11 ENSRNOT00000017164 0.11 2.15E-06 Alg12 ENSRNOT00000006139 0.12 1.11E-04 Alg14 NM_001014176 -0.11 3.48E-04 Alg3 NM_001011897 0.06 5.02E-03 Alg5 NM_001025407 0.15 7.65E-12 Alg6 NM_001033709 0.1 4.25E-03 Alg9 ENSRNOT00000029137 0.12 1.81E-07 Alkbh5 CA504904 -0.09 0.02 Alox15 NM_031010 0.08 2.35E-03 Alpi NM_022665 0.09 0.04 Als2 XM_001061827 -0.19 7.06E-08 Als2cr2 g18192108 0.09 0.02 Als2cr4 ENSRNOT00000031858 0.1 1.40E-03 Amacr NM_012816 0.06 0.03 Ambp NM_012901 -0.18 3.63E-03 Amfr CV116197 0.05 0.03 Anapc1 704208701H1 -0.09 0.01 Anapc5 NM_001080147 -0.04 7.46E-03 Anapc7 XM_001079480 -0.06 0.02 Ank NM_053714 0.07 5.10E-03 Ankmy2 ENSRNOT00000007562 0.16 1.48E-05 Ankrd10 CO566009 -0.13 1.97E-03 Ankrd13c CK477145 0.08 0.01 Ankrd39 ENSRNOT00000021685 0.18 3.67E-09 Ankrd44 ENSRNOT00000015509 0.15 0.03 Ankrd46 NM_001013948 0.04 0.02 Ankrd56 BF394727 0.06 0.02 Ankrd57 DY318217 0.19 4.17E-05 Ankrd9 NM_001012112 0.15 1.38E-03 Anks1 ENSRNOT00000059373 -0.17 2.18E-04 Anks3 NM_001009676 0.06 0.03 Anp32a CB696160 -0.63 8.82E-18 Anp32b NM_131911 -0.15 1.83E-10 Anxa11 NM_001011918 0.08 1.67E-04 Anxa13 ENSRNOT00000010894 0.16 4.68E-03 Anxa2 NM_019905 -0.18 9.97E-11 Anxa3 NM_012823 -0.11 0.02 Diabetes Page 200 of 288

Anxa4 NM_024155 -0.35 3.64E-12 Anxa5 CO393102 0.14 2.49E-04 Anxa6 NM_024156 0.17 0.03 Anxa7 NM_130416 0.11 1.15E-03 Ap1g1 ENSRNOT00000051859 0.14 8.09E-05 Ap1s2 XM_001068004 0.09 0.03 Ap2m1 NM_053837 0.04 0.04 Ap2s1 NM_022952 0.08 1.45E-04 Ap3b1 ENSRNOT00000014278 0.12 7.42E-04 Ap3b2 BI298352 -0.13 0.04 Ap3s1 ENSRNOT00000005222 0.08 0.01 Ap4b1 ENSRNOT00000026382 -0.08 2.38E-03 Apaf1 NM_023979 0.15 0.01 Aph1a NM_001014255 0.1 3.87E-03 Api5 DQ480749 0.09 7.99E-06 Apip ENSRNOT00000009797 0.06 0.02 Aplp2 M31322 -0.18 7.79E-05 Apobec4 NM_001017492 0.11 0.04 Apod NM_012777 0.2 0.02 Apool NM_001014105 0.09 4.95E-04 Appbp2 g11659913 -0.22 2.08E-06 Appl2 ENSRNOT00000010986 -0.11 2.57E-04 Aprt NM_001013061 0.08 1.89E-04 Aqp11 NM_173105 0.07 0.03 Aqp5 NM_012779 -0.15 0.02 Araf NM_022532 0.14 0.03 Arcn1 NM_001007662 0.06 0.02 Ard1 ENSRNOT00000051254 0.17 3.86E-10 Arf1 ENSRNOT00000048559 -0.03 0.05 Arf2 NM_024150 -0.1 0.02 Arf3 NM_080904 -0.06 1.79E-03 Arf4 NM_024151 0.08 1.58E-03 Arf4l ENSRNOT00000028178 -0.14 0.01 Arf6 NM_024152 0.05 0.03 Arfgap1 ENSRNOT00000041309 0.13 0.01 Arfip2 NM_001004222 0.11 5.42E-04 Arfrp1 NM_053980 -0.17 1.06E-14 Arg1 DY553854 -0.2 7.41E-03 Argbp2 NM_053770 -0.09 0.04 Arhgap12 XM_225439 0.08 0.01 Arhgap17 g11675390 -0.08 0.03 Arhgap5 NM_001047869 0.06 4.97E-04 Arhgef3 ENSRNOT00000019511 -0.12 0.02 Arhgef4 ENSRNOT00000018935 0.09 0.05 Arid1a ENSRNOT00000009173 -0.14 0.04 Arid4a ENSRNOT00000031595 0.19 3.38E-03 Arid4b BE117689 -0.18 3.53E-04 Page 201 of 288 Diabetes

Arih1 703829854J1 -0.11 2.21E-05 Arih2 EV774720 0.15 5.05E-05 Arl3 NM_022700 0.05 0.01 Arl4a NM_019186 0.16 1.43E-04 Arl5a NM_053979 -0.13 7.79E-03 Arl6 ENSRNOT00000043337 0.15 3.73E-05 Arl6ip6 NM_001024310 0.11 1.52E-05 Arl8b NM_001024332 0.07 2.22E-04 Armc1 ENSRNOT00000018548 -0.05 4.20E-03 Armc10 BC079464 -0.05 0.02 Armc4 ENSRNOT00000025585 -0.07 0.04 Armc5 NM_001009455 -0.07 0.02 Armc6 ENSRNOT00000027550 -0.09 1.54E-03 Armcx1 NM_001024367 0.17 1.90E-04 Armcx2 NM_001014274 0.1 3.69E-04 Armcx3 NM_001014273 -0.13 6.29E-13 Arpc1a NM_031146 0.06 3.13E-03 Arpc1b NM_019289 0.1 1.94E-03 Arpc4 XM_001078712 -0.09 1.42E-05 Arpc5 NM_001025717 0.06 0.05 Arsb BP498238 -0.08 3.84E-03 Arsi NM_001047881 0.07 0.04 Asah1 NM_053407 0.14 2.12E-09 Asahl NM_001010967 0.19 1.19E-03 Asb9 ENSRNOT00000041515 0.09 0.01 Ascc2 ENSRNOT00000009990 0.08 0.03 Asf1b ENSRNOT00000006964 0.07 0.01 Asl NM_021577 0.18 3.56E-05 Asna1 ENSRNOT00000005122 0.05 0.04 Asns NM_013079 0.05 0.04 Aspm ENSRNOT00000016797 -0.11 0.03 Atad2 BF408842 -0.07 0.03 Atad3a NM_001034922 0.08 4.98E-03 Atf7ip ENSRNOT00000055702 -0.09 6.70E-04 Atg12 NM_001038495 -0.28 3.73E-22 Atg3 NM_134394 0.08 3.03E-03 Atg4b NM_001025711 0.08 5.52E-04 Atg4c ENSRNOT00000011631 -0.12 0.03 Atp10a BC107909 0.33 1.69E-06 Atp11a ENSRNOT00000057639 0.17 5.60E-06 Atp1b1 M14137 0.14 3.18E-04 Atp2a2 AF043106 0.12 5.66E-08 Atp2a3 NM_012914 -0.17 1.67E-03 Atp2c2 NM_134462 -0.14 8.65E-07 Atp5f1 NM_134365 0.05 0.02 Atp5g3 NM_053756 -0.44 5.61E-44 Atp5i NM_080481 0.05 0.02 Diabetes Page 202 of 288

Atp5o NM_138883 0.09 5.42E-04 Atp5s ENSRNOT00000006509 0.11 1.73E-03 Atp6ap1 NM_031785 0.08 7.15E-04 Atp6ap2 ENSRNOT00000005138 0.06 4.00E-05 Atp6v0a1 DQ286421 -0.19 7.89E-09 Atp6v0c NM_130823 -0.13 3.63E-07 Atp6v1a1 ENSRNOT00000002727 -0.29 4.12E-14 Atp6v1b2 NM_057213 -0.05 0.04 Atp8b1 ENSRNOT00000038652 0.17 6.74E-07 Atp9b ENSRNOT00000041380 -0.09 1.40E-04 Atpbd1b ENSRNOT00000009275 0.07 0.02 Atpbd1c NM_201991 0.12 9.35E-05 Atpbd4 BF391057 0.08 0.04 Atrn AB038388 0.17 2.94E-07 Atrx ENSRNOT00000042751 -0.24 4.27E-07 Auh ENSRNOT00000015786 0.11 1.03E-05 Aup1 NM_001079899 0.13 2.74E-03 Aurka ENSRNOT00000006323 -0.26 8.61E-13 Avpi1 NM_134373 0.2 8.89E-10 Azi2 CK845014 0.11 0.02 Azin1 NM_022585 -0.2 8.42E-15 B3galnt1 NM_001013158 0.09 4.35E-03 B3gat2 NM_022609 0.13 1.34E-03 B4galnt1 NM_022860 0.08 0.02 B4galt2 AI710662 -0.11 0.01 B4galt3 NM_001009539 -0.15 1.85E-10 B9d1 ENSRNOT00000003402 0.14 1.62E-04 Bace2 CK845225 0.1 0.04 Bad NM_022698 0.08 3.69E-04 Bag1 ENSRNOT00000011455 0.08 1.16E-04 Bag3 NM_001011936 -0.13 1.37E-03 Bag5 NM_001008526 0.07 4.62E-03 Baiap2l1 NM_001034140 0.09 7.88E-04 Bat1a DY316157 -0.15 1.41E-04 Bbs2 NM_053618 -0.12 1.31E-05 Bbs4 ENSRNOT00000031262 0.09 0.02 Bbs7 NM_001012180 0.1 0.01 Bcas2 ENSRNOT00000025592 -0.49 0 Bcat2 NM_022400 0.19 1.40E-03 Bckdhb ENSRNOT00000013249 0.15 8.39E-04 Bckdk BQ782172 -0.28 9.53E-33 Bcl10 NM_031328 0.12 1.47E-08 Bcl2 S74122 0.05 7.76E-03 Bcl2l1 S76513 -0.13 1.74E-03 Bcl2l13 ENSRNOT00000016561 0.05 0.02 Bcl2l2 NM_021850 0.1 0.03 Bclaf1 BE109170 -0.16 3.31E-03 Page 203 of 288 Diabetes

Bcr ENSRNOT00000001766 0.09 1.43E-03 Bcs1l NM_001007666 0.11 1.12E-03 Bdh1 NM_053995 0.16 4.94E-07 Bdnf M61175 0.29 7.67E-16 Bdp1 ENSRNOT00000024023 -0.29 2.19E-09 Bet1l NM_019368 0.15 5.71E-06 Bex2 NM_001077435 -0.09 2.71E-04 Bex4 NM_001037554 0.06 0.01 Bhlhb2 NM_053328 -0.45 8.58E-07 Bhlhb3 g11402087 -0.28 1.56E-09 Bhlhb4 ENSRNOT00000013690 -0.08 0.03 Bicc1 ENSRNOT00000058159 0.11 0.03 Bicd1 ENSRNOT00000055435 0.13 0.03 Bik NM_053704 -0.28 2.58E-03 Bin3 NM_001013186 0.11 6.90E-03 Blcap NM_133582 0.11 7.08E-05 Bles03 NM_001024233 0.22 3.51E-04 Blmh NM_001034163 0.09 5.68E-06 Bloc1s2 NM_001037349 -0.04 0.03 Blvra NM_053850 0.09 3.83E-03 Blzf1 CK843377 0.09 0.02 Bmp2 NM_017178 0.38 6.87E-03 Bmpr1a NM_030849 0.07 0.04 Bmyc NM_001013163 0.09 2.26E-04 Bnip2 BF282292 -0.27 2.07E-17 Bnip3l NM_080888 -0.12 1.89E-03 Bok ENSRNOT00000024526 0.07 0.03 Bola3 ENSRNOT00000031583 0.17 2.88E-09 Bop1 NM_001024250 0.1 6.75E-03 Bpgm EV764831 0.11 1.46E-06 Bpi NM_001004079 -0.1 0.03 Bpnt1 NM_171990 0.26 0.04 Brca1 NM_012514 -0.14 2.64E-05 Brd4 ENSRNOT00000060345 0.09 0.04 Brd8 NM_001008509 -0.08 0.01 Brdt ENSRNOT00000002842 -0.08 6.32E-04 Brf2 NM_001024773 0.09 2.63E-04 Bri3 NM_001009604 -0.41 3.96E-20 Bri3bp NM_001017487 0.07 1.75E-03 Brms1 XM_001072516 0.12 7.42E-03 Brms1l ENSRNOT00000010948 0.11 0.03 Brp16 CB544959 0.09 0.01 Brp44l NM_133561 0.16 6.44E-08 Brs3 NM_152845 0.24 3.56E-04 Bscl2 NM_001012171 0.09 0.04 Btaf1 ENSRNOT00000054751 0.15 9.41E-04 Btbd10 NM_001014022 0.14 7.09E-05 Diabetes Page 204 of 288

Btbd14b AW254163 0.1 0.01 Btbd3 ENSRNOT00000010835 0.11 8.21E-03 Btg1 NM_017258 -0.1 6.43E-04 Btg2 BI278296 -0.21 1.05E-07 Btg3 NM_019290 0.1 6.27E-07 Btrc NM_001007148 0.07 0.02 Bud13 NM_001025277 0.1 2.27E-04 Bwk1 NM_198743 0.05 0.03 Bxdc2 NM_001029915 0.08 4.30E-03 Bysl NM_182674 0.11 2.76E-07 Bzw1 AI407864 0.27 3.05E-09 C11orf8h NM_198778 -0.1 5.49E-03 C1qbp NM_019259 0.05 0.02 C1ql3 ENSRNOT00000023637 0.1 7.62E-04 C1qtnf6 NM_001034932 -0.11 2.54E-05 C1r ENSRNOT00000015897 -0.25 9.26E-04 C4bpb NM_016995 0.08 0.03 Ca5a NM_019293 -0.09 0.01 Cabc1 NM_001013185 -0.11 0.02 Cables1 ENSRNOT00000017187 -0.15 9.90E-03 Cables2 ENSRNOT00000008279 -0.11 9.74E-03 Cabp1 NM_001033676 -0.17 9.88E-03 Cachd1 ENSRNOT00000057828 -0.06 0.02 Cacna1a AM040230 -0.36 1.17E-07 Cacna1e AF057029 -0.07 6.87E-03 Cacna1h NM_153814 -0.21 5.51E-03 Cacna2d4 ENSRNOT00000010746 0.06 0.02 Cacnb2 NM_053851 -0.12 1.08E-07 Cacnb3 NM_012828 -0.17 3.09E-03 Cadps NM_013219 -0.33 2.91E-34 Calb1 NM_031984 0.31 2.66E-12 Calm1 BP466513 0.03 0.03 Calu NM_001033898 -0.11 1.42E-03 Camk1 NM_134468 0.1 0.02 Camk1g NM_182842 -0.09 0.01 Camk2b ENSRNOT00000005359 -0.11 1.09E-03 Camk2d BC107562 0.08 2.06E-04 Camk2g BF416307 -0.06 0.02 Camk2n1 NM_173337 -0.15 0.05 Camk2n2 BP468561 0.11 0.01 Camk4 ENSRNOT00000009507 0.09 0.04 Camkk1 NM_031662 -0.16 0.03 Camsap1 ENSRNOT00000024163 0.11 2.85E-03 Canx 703890130J1 0.04 9.00E-03 Capn10 NM_031673 0.13 1.30E-03 Capn2 NM_017116 -0.13 1.44E-03 Capsl ENSRNOT00000023378 0.15 0.04 Page 205 of 288 Diabetes

Car8 NM_001009662 -0.12 0.01 Cart NM_017110 0.09 0.02 Casc1 CK841754 0.1 0.02 Casc3 AW920695 -0.18 1.14E-03 Casc4 ENSRNOT00000038291 -0.12 1.20E-03 Cask NM_022184 0.11 6.55E-05 Casp3 NM_012922 -0.11 7.76E-03 Casp6 NM_031775 0.16 1.08E-04 Casr NM_016996 -0.28 2.13E-03 Cast ENSRNOT00000048560 0.11 0.04 Catsper2 BP485207 0.16 2.49E-06 Cbl ENSRNOT00000011250 -0.08 0.03 Cbll1 ENSRNOT00000009566 -0.09 1.86E-03 Cbr4 NM_182672 0.12 6.58E-07 Cbwd1 NM_133535 0.14 3.06E-03 Cbx1 XM_001081346 -0.3 2.46E-32 Cbx5 ENSRNOT00000055289 -0.06 2.03E-03 Cbx6 NM_001012119 0.11 0.05 Cbx8 NM_001034078 0.06 0.02 Cby1 NM_145676 0.11 5.71E-03 Ccbl1 NM_001013164 -0.08 6.57E-03 Ccdc104 NM_001024866 0.06 0.04 Ccdc107 ENSRNOT00000023411 0.12 1.49E-04 Ccdc109a XM_001054087 0.17 1.03E-05 Ccdc115 ENSRNOT00000017722 0.09 4.30E-03 Ccdc117 CF112977 -0.31 4.49E-09 Ccdc124 ENSRNOT00000025626 0.06 0.02 Ccdc126 ENSRNOT00000012490 0.08 2.80E-03 Ccdc129 XM_575491 0.12 2.19E-03 Ccdc21 NM_001080151 0.1 0.04 Ccdc22 ENSRNOT00000015546 0.08 0.03 Ccdc23 NM_001038992 0.1 1.25E-03 Ccdc28a NM_001037789 -0.21 0.05 Ccdc32 NM_001024245 0.14 2.65E-07 Ccdc34 XM_001080076 0.08 0.04 Ccdc41 AI031052 0.13 2.18E-05 Ccdc43 ENSRNOT00000003685 0.17 4.45E-09 Ccdc49 AI317837 0.11 1.40E-03 Ccdc58 ENSRNOT00000042208 0.08 0.01 Ccdc59 ENSRNOT00000005740 -0.09 3.89E-04 Ccdc85b ENSRNOT00000027896 0.14 0.02 Ccdc93 NM_001024997 0.17 2.57E-04 Cck NM_012829 0.12 2.80E-04 Ccl5 NM_031116 -0.12 8.22E-05 Ccna1 NM_001011949 -0.07 2.40E-03 Ccnd2 NM_022267 -0.22 0.01 Ccnd3 NM_012766 0.22 2.87E-03 Diabetes Page 206 of 288

Ccng1 NM_012923 -0.14 8.56E-03 Ccnh CK844518 0.11 2.51E-04 Ccni CO571802 -0.08 6.11E-03 Ccnl2 CD370960 0.06 3.11E-03 Ccny ENSRNOT00000024399 0.1 2.37E-03 Ccpg1 ENSRNOT00000039176 -0.11 3.59E-06 Ccrk NM_001025752 0.17 8.42E-04 Ccrn4lb ENSRNOT00000014348 0.08 8.05E-03 Ccs NM_053425 0.12 3.17E-03 Cct7 ENSRNOT00000021030 0.05 1.51E-03 Cd1d1 NM_017079 -0.32 2.83E-07 Cd200 NM_031518 0.21 5.57E-06 Cd248 ENSRNOT00000027339 0.09 0.01 Cd276 NM_182824 0.1 3.23E-05 Cd300lf NM_001025111 -0.16 4.31E-05 Cd320 NM_001014201 0.14 1.15E-05 Cd36 BF285342 0.14 0.04 Cd46 NM_019190 -0.09 0.03 Cd55 NM_022269 0.14 4.83E-04 Cd82 NM_031797 0.1 2.19E-05 Cd83 ENSRNOT00000024458 -0.19 1.91E-05 Cd99l2 NM_134459 0.14 1.15E-04 Cdc14b ENSRNOT00000025706 -0.17 1.13E-03 Cdc23 ENSRNOT00000037888 0.16 2.16E-12 Cdc25b NM_133572 0.09 0.02 Cdc25c ENSRNOT00000060771 0.09 1.17E-03 Cdc27 BI299689 -0.13 4.37E-06 Cdc2a NM_019296 -0.11 5.01E-06 Cdc2l6 g14960432 -0.34 1.16E-05 Cdc34 NM_001013103 0.12 1.60E-03 Cdc37l1 NM_001011941 -0.1 6.58E-04 Cdc40 XM_342154 -0.23 1.00E-13 Cdc42ep4 ENSRNOT00000048264 -0.21 5.64E-05 Cdc42ep5 ENSRNOT00000025110 -0.14 0.02 Cdc45l XM_001061676 -0.16 1.76E-05 ENSRNOT00000038228 -0.07 0.03 Cdca2 BC105847 0.1 4.42E-04 Cdca7 NM_001025693 -0.07 0.02 Cdh1 NM_031334 -0.25 2.56E-07 Cdh2 BQ192644 0.14 2.02E-04 Cdipt NM_138899 0.07 3.16E-03 Cdk2 NM_199501 -0.1 5.24E-06 Cdk4 BP473569 -0.06 0.05 Cdkl3 NM_021772 0.11 0.02 Cdkn1a DN947728 -0.3 0.03 Cdkn1b NM_031762 0.08 4.20E-04 Cdkn2aip NM_001014000 -0.12 4.13E-03 Page 207 of 288 Diabetes

Cdkn2aipnl DN933971 0.07 6.21E-03 Cdo1 NM_052809 0.11 0.01 Cdr2 NM_001025682 0.15 4.24E-07 Cds1 NM_031242 0.16 2.99E-07 Cdt1 ENSRNOT00000018923 -0.14 0.01 Cebpd NM_013154 0.2 5.38E-03 Cebpz ENSRNOT00000006824 -0.18 2.09E-10 Cecr5 ENSRNOT00000015090 0.08 0.02 Cenpn ENSRNOT00000058752 -0.13 9.88E-06 Cenpt NM_001024257 -0.1 8.77E-03 Centg2 XM_237381 0.06 0.02 Cep135 ENSRNOT00000032156 0.11 0.02 Cep152 ENSRNOT00000031268 -0.11 0.02 Cep55 NM_001025646 0.17 2.55E-12 Cep68 ENSRNOT00000039523 0.08 0.02 Cep70 NM_001017470 -0.11 0.05 Cep72 ENSRNOT00000020780 -0.16 2.31E-07 Cep76 ENSRNOT00000059003 0.11 1.92E-05 Cerk ENSRNOT00000022882 -0.09 7.78E-03 Cetn3 ENSRNOT00000021735 -0.12 8.88E-05 Cfl2 XM_001079054 0.2 3.26E-16 Cflar NM_057138 0.09 3.02E-05 Cgn ENSRNOT00000028440 -0.16 9.16E-04 Cgrrf1 NM_053899 0.13 6.63E-05 Chac2 NM_001025016 0.19 1.83E-04 Chchd3 XM_238346 0.08 6.56E-03 Chchd6 XM_216212 0.07 4.20E-04 Chchd8 ENSRNOT00000038764 0.12 6.15E-05 Chd3 ENSRNOT00000012983 -0.14 2.01E-03 Chd6 ENSRNOT00000022861 -0.22 1.12E-04 Chek2 NM_053677 -0.09 2.92E-03 Chic2 ENSRNOT00000003085 -0.07 2.87E-05 Chid1 NM_001047854 0.15 5.42E-05 Chml XM_001058878 0.27 6.13E-04 Chmp2b XM_001063932 -0.13 6.35E-11 Chmp7 ENSRNOT00000023318 0.06 0.02 Chordc1 ENSRNOT00000030569 0.07 3.09E-04 Chpf NM_001005906 0.1 0.04 Chrnd NM_019298 -0.08 0.04 Chst1 NM_001011955 -0.14 2.85E-08 Chst8 ENSRNOT00000037700 -0.15 2.53E-03 Chsy1_predicted ENSRNOT00000016939 -0.22 7.80E-04 Ciao1 NM_001008766 0.07 2.75E-04 Ciapin1 NM_001007689 0.06 0.02 Cib2 NM_001015010 0.11 5.47E-04 Cinp BC097975 0.07 6.60E-03 Cipar1 NM_173114 -0.32 3.47E-05 Diabetes Page 208 of 288

Cirbp NM_031147 -0.36 0 Cirh1a NM_001009640 0.15 4.54E-14 Cisd1 ENSRNOT00000000749 0.04 9.99E-03 Cit BQ211439 -0.09 0.04 Cited4 NM_053699 0.12 6.42E-04 Ckap4 ENSRNOT00000010601 0.19 1.57E-03 Ckb NM_012529 0.16 1.29E-05 Clca5 ENSRNOT00000018435 0.06 0.05 Clcn2 NM_017137 0.19 0.01 Clcn6 ENSRNOT00000011287 -0.05 0.05 Cldn23 NM_001033062 0.08 0.04 Cldnd1 NM_001006955 0.13 1.34E-04 Clec2d ENSRNOT00000010098 -0.08 0.05 Clec4e NM_001005897 -0.14 0.02 Clic2 NM_001009651 -0.19 2.74E-08 Clip1 NM_031745 0.12 0.01 Clip3 ENSRNOT00000028247 -0.1 7.39E-03 Clmn ENSRNOT00000048197 -0.08 3.23E-04 Clp1 NM_001009599 0.17 1.49E-18 Clpp XM_217313 0.08 8.24E-06 Clptm1l ENSRNOT00000023211 0.11 1.16E-06 Clstn1 ENSRNOT00000045063 0.1 9.63E-06 Cmpk2 ENSRNOT00000052003 0.12 0.02 Cmtm1 CR463479 -0.16 0.02 Cmtm4 702082415F6 -0.4 7.53E-31 Cmtm7 XM_001076838 0.09 2.17E-04 Cndp2 NM_001010920 0.09 5.01E-06 Cnih ENSRNOT00000013331 -0.19 8.24E-19 Cnih4 ENSRNOT00000004939 -0.1 2.49E-04 Cnksr3 NM_001012061 -0.16 0.04 Cnn3 NM_019359 0.08 4.11E-05 Cnnm2 NM_001011942 0.19 2.70E-03 Cnnm3 ENSRNOT00000059801 -0.14 0.01 Cno 704149177J1 -0.12 4.21E-05 Cnot2 ENSRNOT00000006779 -0.05 0.03 Cnot6 704227082H1 -0.33 4.93E-14 Cnot7 ENSRNOT00000016882 -0.2 6.00E-10 Cnpy2 NM_001077585 0.06 3.15E-03 Cnpy4 ENSRNOT00000033288 0.07 0.05 Cnrip1 NM_001014232 -0.09 4.87E-08 Cntfr NM_001003929 -0.3 0.03 Cntn1 NM_057118 -0.12 2.79E-05 Cntn3 NM_019329 0.22 1.42E-08 Cntnap4 ENSRNOT00000015337 0.11 4.43E-03 Cobll1 ENSRNOT00000001606 0.09 8.73E-03 Cobra1 ENSRNOT00000012978 0.07 3.04E-03 Cog1 ENSRNOT00000003804 -0.09 4.39E-03 Page 209 of 288 Diabetes

Col5a3 NM_021760 -0.12 0.04 Col9a1 ENSRNOT00000018116 0.09 0.04 Commd2 ENSRNOT00000022778 -0.13 1.38E-04 Commd3 NM_198732 -0.09 3.13E-05 Commd5 NM_139108 0.05 7.76E-03 Commd8 XM_001069497 0.22 1.04E-11 Commd9 NM_001033692 0.11 3.34E-03 Comtd1 ENSRNOT00000018897 0.11 0.05 Copb2 NM_021765 0.11 8.01E-07 Cope XM_001068587 0.09 6.81E-05 Cops4 AA900596 0.07 0.04 Cops7b XM_343614 0.09 5.27E-03 Cops8 NM_001013227 0.11 6.73E-06 Coq10b NM_001009671 -0.16 1.52E-07 Coq3 NM_019187 0.17 4.71E-09 Coq4 NM_001031662 0.11 3.18E-05 Coq5 NM_001039022 0.11 7.45E-06 Coro1a NM_130411 0.11 7.35E-05 Cox19 ENSRNOT00000001735 0.06 4.80E-03 Cox5a NM_145783 0.05 0.02 Cox5b NM_053586 0.05 0.02 Cp ENSRNOT00000016914 0.12 3.21E-03 Cpd NM_012836 0.22 0.01 Cplx1 NM_022864 0.14 2.04E-04 Cpne8 XM_001056316 -0.25 1.65E-07 Cpox NM_001037095 0.27 2.82E-19 Cpsf3 NM_001030030 0.05 0.04 Cpsf6 CK842415 0.09 7.97E-05 Cpt1a NM_031559 -0.27 2.62E-05 Cpt2 NM_012930 -0.08 2.11E-05 Crabp1 ENSRNOT00000031175 -0.13 1.14E-03 Crabp2 NM_017244 -0.19 8.49E-04 Crat NM_001004085 0.1 0.02 Crb3 NM_001025661 0.08 2.35E-03 Crcp BF397860 0.07 0.03 Creb3 NM_001013092 0.13 3.39E-08 Creb3l1 NM_001005562 -0.06 0.04 Creb3l2 NM_001012188 0.28 1.02E-10 Creg1 BF282301 0.34 5.93E-31 Crem NM_013086 0.15 0.02 Crhr1 NM_030999 -0.16 4.05E-04 Crlf1 ENSRNOT00000060097 -0.14 1.69E-07 Crls1 BQ193838 0.09 3.18E-04 Crot NM_031987 0.15 2.37E-05 Crp NM_017096 -0.14 0.03 Crtc3 g14976091 0.1 0.03 Cry1 NM_198750 0.09 0.02 Diabetes Page 210 of 288

Cry2 NM_133405 0.15 0.02 Crybb3 NM_031690 -0.11 5.81E-03 Crym NM_053955 0.27 6.46E-26 Cryzl1 BI275231 0.1 2.16E-04 Csda NM_031979 0.04 0.02 Csdc2 ENSRNOT00000007091 -0.14 0.02 Csde1 NM_054006 -0.25 3.79E-18 Cse1l ENSRNOT00000010210 -0.25 7.57E-44 Csgalnact2 ENSRNOT00000019778 0.08 0.02 Csnk1a1 NM_053615 -0.08 1.57E-03 Csnk1e NM_031617 -0.08 0.01 Csnk2b NM_001035238 0.06 8.47E-03 Cspg5 NM_133652 -0.35 8.29E-03 Csrp2 NM_177425 -0.11 6.65E-05 Cst8 NM_019258 -0.07 0.03 Cst9 ENSRNOT00000006869 0.11 0.03 Cstb NM_012838 0.08 6.05E-03 Ctage5 ENSRNOT00000006995 0.13 2.74E-07 Ctbp1 BC078778 -0.11 8.46E-04 Ctbp2 NM_053335 0.09 3.67E-03 Ctdspl2 703829205J1 -0.25 2.70E-09 Cth NM_017074 0.19 2.94E-03 Ctnnbip1 ENSRNOT00000055562 0.14 1.60E-03 Ctr9 CA504061 0.1 7.64E-03 Ctrb1 NM_012536 0.08 0.02 Ctsb NM_022597 0.08 0.01 Ctsf NM_001034110 -0.1 1.19E-03 Cttnbp2nl ENSRNOT00000019680 -0.18 3.05E-09 Cuedc2 NM_001079886 -0.09 2.77E-03 Cugbp2 AF169013 -0.13 0.04 Cul1 XM_001069456 0.06 0.03 Cul2 ENSRNOT00000045970 0.09 6.81E-03 Cul3 ENSRNOT00000021528 0.19 7.15E-09 Cul4b XM_001058651 -0.14 2.58E-03 Cwc15 NM_001024987 0.08 3.83E-03 Cwf19l1 ENSRNOT00000017202 -0.11 0.05 Cxadr NM_053570 -0.14 5.33E-04 Cxcl10 NM_139089 -0.19 7.44E-04 Cxcl11 NM_182952 -0.15 2.78E-03 Cxcl16 NM_001017478 -0.24 0.03 Cxcr7 NM_053352 -0.29 2.40E-09 Cyb5 NM_022245 0.07 0.03 Cyb561 XM_001081563 0.1 6.32E-04 Cyb561d1 ENSRNOT00000040396 0.15 1.68E-04 Cyb5r1 NM_001013126 0.09 6.75E-03 Cyb5r4 ENSRNOT00000013975 -0.09 2.23E-03 Cybasc3 NM_001014164 0.08 0.03 Page 211 of 288 Diabetes

Cyc1 ENSRNOT00000017067 0.1 5.32E-06 Cycs NM_012839 0.05 0.02 Cyfip1 ENSRNOT00000016376 0.09 1.83E-05 Cyfip2 ENSRNOT00000008946 -0.09 9.27E-03 Cyld ENSRNOT00000060789 -0.34 5.36E-35 Cyp20a1 NM_199401 0.05 9.48E-03 Cyp2f4 NM_019303 -0.09 2.29E-03 Cyp4a8 M37828 -0.46 2.55E-03 Cyp4f1 NM_019623 -0.14 1.77E-03 Daam1 ENSRNOT00000005927 -0.17 1.24E-04 Dab1 BF406318 -0.11 0.02 Dad1 NM_138910 0.08 5.73E-05 Dap3 NM_001011950 0.06 7.97E-03 Dazap2 NM_001013107 -0.73 0 Dbc1 NM_080482 0.14 1.29E-03 Dbf4 ENSRNOT00000011351 0.09 0.04 Dbi NM_031853 0.06 0.02 Dbp NM_012543 -0.11 5.34E-05 Dbt ENSRNOT00000020267 0.26 5.51E-10 Dc2 XM_001076989 0.09 5.54E-04 Dcbld1 ENSRNOT00000000462 0.23 6.65E-07 Dclk1 NM_053343 -0.22 2.90E-12 Dctd NM_001013882 -0.08 4.00E-03 Dctn3 ENSRNOT00000019561 0.06 0.05 Dcun1d4 ENSRNOT00000002945 -0.09 3.10E-03 Dcxr NM_134387 0.09 0.01 Dd25 NM_199403 0.21 3.53E-05 Ddah1 NM_022297 0.16 3.63E-05 Ddc NM_012545 -0.06 8.99E-03 Ddost NM_001012104 0.05 0.03 Ddx10 ENSRNOT00000017683 0.17 1.02E-05 Ddx17 AA859709 -0.05 0.03 Ddx18 NM_001006996 0.06 0.01 Ddx19 ENSRNOT00000024636 0.09 4.35E-03 Ddx25 NM_031630 0.11 4.32E-03 Ddx28 ENSRNOT00000026817 0.07 7.80E-03 Ddx31 703910857J1 0.13 1.32E-03 Ddx46 BE109072 0.17 1.05E-04 Ddx52 NM_053525 0.17 2.26E-03 Ddx54 BQ191651 0.06 7.62E-03 Ddx56 NM_001004211 0.14 2.32E-09 Ddx59 NM_001005535 -0.08 6.24E-03 Decr1 NM_057197 0.05 1.54E-03 Dedd NM_031800 -0.17 1.95E-07 Def8 NM_001024774 -0.31 1.45E-11 Defb36 NM_001037515 0.13 6.07E-04 Degs1 NM_053323 -0.31 5.66E-33 Diabetes Page 212 of 288

Dek NM_001004255 -0.28 5.24E-24 Dennd1b ENSRNOT00000043907 -0.48 3.74E-22 Dennd2a ENSRNOT00000034549 -0.07 3.91E-03 Depdc1a XM_001080406 0.1 5.56E-03 Derl1 CR754764 0.07 4.84E-03 Dexi ENSRNOT00000003544 -0.14 2.06E-08 Dffa NM_053679 0.19 5.68E-07 Dgat1 NM_053437 0.08 0.05 Dgat2 NM_001012345 0.16 1.65E-16 Dgcr14 NM_001012472 0.07 0.03 Dgcr8 ENSRNOT00000002581 -0.14 2.23E-07 Dgki AW526027 0.13 2.79E-03 Dguok ENSRNOT00000015526 -0.11 5.12E-03 Dhcr24 ENSRNOT00000009402 -0.19 1.42E-09 Dhfr NM_130400 0.06 0.04 Dhrs1 NM_001007621 0.12 2.01E-06 Dhrsx ENSRNOT00000029485 -0.08 0.04 Dhtkd1 NM_001025720 0.31 1.53E-12 Dhx37 ENSRNOT00000030823 -0.14 1.76E-06 Dhx8 NM_001047844 0.15 1.25E-06 Diap1 BQ205774 -0.15 2.66E-03 Dicer1 ENSRNOT00000014405 0.12 4.92E-04 Dip2a ENSRNOT00000001728 -0.06 0.04 Diras2 ENSRNOT00000044842 0.08 0.04 Dis3 ENSRNOT00000037588 0.12 9.30E-03 Dixdc1 NM_001037654 -0.38 1.41E-13 Dkk2 XM_001077211 0.23 0.02 Dlat 702385582H1 0.11 3.73E-06 Dld NM_199385 0.11 2.21E-06 Dlg2 NM_022282 0.2 1.09E-04 Dlst NM_001006981 0.09 1.60E-03 Dmd NM_012698 0.11 0.02 Dmrt2 ENSRNOT00000021828 -0.1 0.03 Dmxl2 XM_001075770 -0.06 0.01 Dnah9 D26500 -0.23 2.47E-03 Dnaic1 NM_001024342 -0.1 8.23E-04 Dnaja1 NM_022934 -0.06 0.01 Dnaja2 NM_032079 -0.19 1.51E-18 Dnaja3 NM_001038596 0.11 4.06E-04 Dnajb11 NM_001015021 0.1 4.21E-05 Dnajb12 CK839791 -0.05 0.02 Dnajb14 BQ781541 -0.13 6.93E-10 Dnajb4 NM_001013076 0.1 0.04 Dnajb5 ENSRNOT00000000142 0.11 1.35E-03 Dnajc10 BC100105 0.08 0.03 Dnajc12 NM_001034032 0.06 0.05 Dnajc15 ENSRNOT00000012530 0.15 1.09E-12 Page 213 of 288 Diabetes

Dnajc16 NM_001014194 0.21 5.32E-04 Dnajc21 NM_138856 0.11 8.37E-04 Dnajc3 NM_022232 0.1 7.50E-06 Dnajc4 NM_001013196 0.09 0.02 Dnase1l1 NM_001014223 0.1 0.03 Dnd1 NM_001025414 0.05 0.02 Dner ENSRNOT00000022564 0.24 2.72E-06 Dnm1l ENSRNOT00000002478 0.13 1.03E-05 Dnmbp XM_001060754 0.1 0.05 Dnmt1 CA506965 -0.09 2.10E-03 Dock8 ENSRNOT00000015668 -0.15 1.11E-03 Dock9 ENSRNOT00000045519 -0.14 2.37E-05 Dohh NM_001025006 0.07 0.02 Dolk ENSRNOT00000022786 0.15 3.52E-06 Dolpp1 ENSRNOT00000024385 0.05 0.04 Donson NM_001008287 -0.1 2.69E-03 Dpf2 ENSRNOT00000028363 -0.08 0.01 Dph4 XM_342483 0.23 2.27E-13 Dpm1 AI171065 0.11 1.78E-04 Dpm2 NM_019252 0.09 6.27E-06 Dpp3 NM_053748 0.09 4.49E-03 Dpp4 CF109988 0.09 0.03 Dpp6 BP469376 -0.06 0.03 Dpp8 704214493H1 0.06 0.01 Dpysl3 704297194J1 -0.63 0 Dr1 NM_001011914 -0.13 1.30E-10 Drap1 NM_001077668 0.05 0.03 Drd2 NM_012547 0.18 0.02 Dsc2 NM_001033688 -0.11 6.12E-04 Dscc1 ENSRNOT00000036399 -0.05 2.08E-03 Dscr6 ENSRNOT00000002289 0.12 6.76E-04 Dse ENSRNOT00000001093 -0.21 5.99E-05 Dspp NM_012790 -0.06 0.03 Dtd1 ENSRNOT00000012510 0.1 2.70E-04 Dtwd1 NM_001013921 0.07 0.03 Dus3l NM_001034923 -0.08 5.37E-03 Dus4l ENSRNOT00000011068 0.1 0.01 Dusp1 NM_053769 -0.15 0.03 Dusp11 NM_001025650 -0.15 5.80E-05 Dusp12 NM_022248 -0.14 1.31E-07 Dusp19 ENSRNOT00000012290 0.19 3.33E-07 Dusp22 ENSRNOT00000024587 -0.13 2.48E-10 Dusp5 NM_133578 -0.11 4.07E-03 Dut CX570340 -0.14 2.74E-07 Duxbl ENSRNOT00000052224 0.08 7.83E-03 Dync1h1 703992502J1 -0.14 2.12E-03 Dync1i1 NM_019234 0.26 1.51E-07 Diabetes Page 214 of 288

Dync1i2 NM_053880 0.05 0.02 Dynlt3 NM_001013228 0.16 2.84E-09 Dyrk1a NM_012791 0.07 9.44E-03 Dyrk1b BF387050 -0.12 8.33E-03 Dyrk2 ENSRNOT00000010283 -0.08 0.01 Dyrk3 NM_001024767 0.13 6.89E-07 E2f6 AY211263 0.11 1.54E-04 E2f8 ENSRNOT00000035512 -0.08 2.19E-03 Eapa2 NM_001009534 -0.1 0.03 Eapp CB735375 0.1 5.00E-03 Ebna1bp2 NM_001008721 0.07 7.18E-04 Ebp NM_057137 0.09 7.01E-03 Ece2 AI229953 0.18 1.56E-07 Ech1 NM_022594 -0.09 7.55E-05 Eda ENSRNOT00000004505 0.09 0.03 Edg8 NM_021775 -0.11 8.04E-03 Eea1 ENSRNOT00000029764 0.14 0.02 Eed ENSRNOT00000024082 0.09 5.90E-04 Eef1a1 DV723221 -0.48 0 Eefsec ENSRNOT00000017323 0.05 0.02 Eepd1 NM_001014088 -0.33 1.02E-05 Efhd1 ENSRNOT00000021168 0.19 9.67E-04 Efhd2 NM_001031648 0.09 0.02 Efna1 NM_053599 -0.09 0.04 Efna3 AY045577 -0.42 1.25E-05 Efnb3 ENSRNOT00000013955 -0.19 3.25E-04 Efr3a DY471847 -0.27 3.02E-40 Egln1 NM_178334 0.12 0.01 Egln3 NM_019371 -0.19 1.83E-05 Ehbp1 ENSRNOT00000012131 -0.21 6.98E-05 Ehd3 NM_138890 0.15 1.66E-07 Ehd4 NM_139324 0.1 0.04 Ehmt1 XM_001077166 0.13 0.01 Ehmt2 NM_212463 -0.26 4.27E-06 Eid1 XM_001077667 -0.08 7.03E-04 Eif1a NM_001008773 -0.15 8.25E-05 Eif1ad NM_001008305 0.19 3.64E-10 Eif1ay CA505998 0.17 8.90E-09 Eif2ak1 NM_013223 0.07 1.46E-03 Eif2ak2 NM_019335 -0.14 1.58E-04 Eif2b1 NM_172029 0.12 8.79E-08 Eif2b2 NM_032058 0.07 3.78E-03 Eif2b3 NM_133609 -0.07 9.95E-03 Eif2b4 NM_053950 0.07 5.92E-03 Eif2b5 U19516 0.13 2.32E-06 Eif2c1 ENSRNOT00000037728 -0.17 1.67E-05 Eif2c4 ENSRNOT00000035373 -0.27 0.03 Page 215 of 288 Diabetes

Eif3h NM_198751 -0.18 1.29E-10 Eif3k AI103157 0.05 6.40E-03 Eif3s9 NM_001031640 0.09 1.24E-03 Eif4a2 NM_001008335 -0.1 8.04E-09 Eif4b NM_001008324 -0.07 5.63E-03 Eif4e2 XM_343616 0.11 1.05E-05 Eif4e3 ENSRNOT00000013719 0.18 9.56E-05 Eif4ebp2 NM_001033069 -0.16 0.05 Eif4enif1 ENSRNOT00000024993 -0.12 6.48E-04 Eif4g3 BP489609 -0.05 0.04 Eif5a2 ENSRNOT00000015779 -0.15 0.04 Eif6 NM_001037352 0.1 1.62E-03 Elac1 ENSRNOT00000000125 0.11 7.87E-03 Elac2 NM_172326 0.07 0.05 Elavl1 ENSRNOT00000001415 0.05 0.03 Elavl2 NM_173309 0.14 9.38E-04 Elf1 DV713576 -0.2 0.03 Elk4 704232218H1 -0.09 0.02 Ell ENSRNOT00000026846 0.08 0.02 Ell2 ENSRNOT00000032974 0.13 4.85E-03 Elmo2 ENSRNOT00000049262 -0.09 0.03 Elmo3 NM_001030028 -0.14 0.01 Elovl4 XM_001062735 0.21 2.68E-11 Elovl6 NM_134383 0.08 0.03 Emb NM_053719 0.07 9.56E-03 Emd NM_012948 0.04 0.05 Emg1 ENSRNOT00000017334 0.13 3.15E-03 Emilin2 XM_237520 -0.18 4.02E-05 Eml1 XM_001069752 -0.15 1.31E-03 Eml4 ENSRNOT00000061931 0.07 0.02 Eml5 ENSRNOT00000005978 -0.11 4.64E-03 Enc1 DQ282125 -0.24 3.09E-05 Eno2 BC060310 0.11 0.04 Enoph1 NM_001009391 0.04 0.03 Enpp5 AA819558 0.08 0.02 Entpd4 ENSRNOT00000022440 0.08 0.03 Entpd6 NM_053498 0.13 3.45E-03 Entpd7 ENSRNOT00000023111 0.2 1.77E-05 Ep300 ENSRNOT00000000206 -0.16 2.84E-03 Ep400 ENSRNOT00000056736 -0.1 0.05 Epb4.1l1 NM_021681 0.13 9.75E-03 Epb4.1l4a ENSRNOT00000038247 -0.11 0.04 Epdr1 NM_001007625 0.08 5.99E-05 Epha4 CA505840 0.11 0.04 Epha7 NM_134331 0.14 8.96E-06 Ephb3 ENSRNOT00000044896 0.08 0.02 Ephx2 NM_022936 0.13 1.24E-04 Diabetes Page 216 of 288

Epn2 NM_021852 -0.32 0 Eps8 703959071J1 -0.19 2.00E-16 Eraf ENSRNOT00000027297 -0.08 0.02 Erbb3 BP486067 0.07 0.03 Ercc1 ENSRNOT00000024113 0.07 0.01 Ercc8 ENSRNOT00000013598 0.16 1.39E-07 Erich1 XM_001075018 0.08 0.03 Ermp1 NM_184050 -0.09 7.19E-03 Ero1l BC071175 0.22 6.50E-21 Ero1lb ENSRNOT00000003526 -0.45 1.34E-08 Esam NM_001004245 0.05 0.03 Esd ENSRNOT00000013324 0.1 8.90E-06 Esf1 ENSRNOT00000006333 0.08 4.55E-03 Espn NM_019622 -0.13 5.65E-06 Ethe1 ENSRNOT00000027075 0.09 2.93E-04 Etnk1 BC089927 -0.25 7.98E-31 Etv1 700525503F6 -0.37 1.06E-06 Exoc5 NM_022204 -0.15 6.19E-06 Exoc7 NM_022691 0.04 0.02 Exosc3 ENSRNOT00000016582 0.1 0.04 Exosc4 CV795768 0.16 5.28E-03 Exosc5 ENSRNOT00000028026 0.13 2.95E-07 Exosc7 ENSRNOT00000005975 -0.16 3.73E-07 Ext1 ENSRNOT00000037809 0.2 3.69E-07 Ext2 ENSRNOT00000012161 0.08 2.46E-03 Extl3 NM_020097 -0.14 0.01 Eya3 703957179J1 0.08 0.03 Ezh2 BP490274 -0.05 8.96E-03 F11r NM_053796 -0.26 7.24E-12 F2r NM_012950 -0.17 8.65E-09 Fabp3 NM_024162 0.09 5.55E-03 Fabp5 NM_145878 0.13 8.09E-04 Fadd ENSRNOT00000028302 0.1 0.04 Fads1 NM_053445 -0.15 1.49E-04 Fah NM_017181 0.13 3.74E-09 Fahd1 NM_001024991 0.06 7.96E-04 Faim NM_080895 0.12 6.76E-07 Fam100b ENSRNOT00000013359 -0.12 5.17E-04 Fam101b NM_001007611 0.24 3.21E-08 Fam102b ENSRNOT00000039225 -0.22 7.88E-04 Fam108a1 NM_001006983 0.13 2.83E-03 Fam117a ENSRNOT00000005939 -0.06 0.04 Fam119a ENSRNOT00000019670 0.16 0.01 Fam120b CB328346 0.09 7.69E-04 FAM120C ENSRNOT00000003565 0.18 0.02 Fam122a NM_001014029 0.07 0.02 Fam126a ENSRNOT00000014023 0.18 8.65E-03 Page 217 of 288 Diabetes

Fam128b ENSRNOT00000002511 0.08 6.41E-04 Fam131b NM_001025046 0.15 8.13E-04 Fam148c ENSRNOT00000010555 -0.43 1.93E-06 Fam149b1 BQ783018 0.08 3.28E-04 Fam151b ENSRNOT00000031909 0.07 0.03 Fam152a AW913871 -0.06 0.03 Fam152b CV115270 0.09 3.52E-03 Fam19a5 BQ782870 0.14 1.68E-04 Fam21c NM_199207 0.05 0.04 Fam36a S78734 0.13 4.24E-05 Fam3a BC103644 0.05 0.04 Fam44b NM_001013854 0.11 9.57E-05 Fam45a ENSRNOT00000013845 0.18 1.47E-14 Fam46a ENSRNOT00000056937 0.16 5.81E-04 Fam54b NM_001013935 0.1 6.72E-07 Fam58b NM_001025412 0.13 4.25E-09 Fam69a ENSRNOT00000030479 0.1 2.37E-03 Fam82c NM_001014046 0.16 5.53E-03 Fam83e ENSRNOT00000028564 -0.06 0.03 Fam86a ENSRNOT00000003843 0.07 0.03 Fam92a1 ENSRNOT00000022249 0.03 0.04 Fam92b ENSRNOT00000035651 -0.13 8.91E-05 Fam96a NM_001008327 -0.06 0.03 Fam96b XM_001058416 0.06 0.03 Fam98a NM_001014073 0.11 1.04E-04 Fance ENSRNOT00000006191 -0.1 0.04 Farp1 CK843176 -0.19 1.14E-03 Farsb NM_001004252 0.08 2.58E-03 Fat3 NM_138544 0.1 3.02E-03 Fbl NM_001025643 -0.07 1.84E-04 Fbn2 NM_031826 0.07 0.03 Fbp2 NM_053716 0.17 6.64E-07 Fbxl12 NM_001025700 0.1 4.78E-03 Fbxl6 NM_001005563 -0.09 7.26E-03 Fbxo16 NM_001013132 0.07 0.03 Fbxo21 ENSRNOT00000001491 -0.25 1.32E-07 Fbxo22 NM_001037770 -0.27 1.25E-12 Fbxo3 704295742J1 -0.07 0.03 Fbxo5 ENSRNOT00000029416 -0.06 0.02 Fbxo9 NM_001011998 0.08 0.01 Fbxw2 ENSRNOT00000025399 0.1 4.76E-04 Fem1a NM_001025706 0.05 0.05 Fen1 NM_053430 -0.07 2.06E-05 Fer1l4 XM_230795 0.17 1.21E-05 Fermt2 NM_001011915 -0.18 2.43E-07 Fert2 ENSRNOT00000021758 0.08 9.01E-04 Fev NM_144753 -0.11 0.01 Diabetes Page 218 of 288

Fez1 NM_031066 -0.09 5.65E-03 Fez2 NM_053600 -0.11 2.19E-04 Ffar1 NM_153304 -0.45 4.55E-14 Fgf13 NM_053428 0.17 4.67E-03 Fgl2 NM_053455 -0.29 4.21E-07 Fh1 NM_017005 0.07 4.48E-03 Fhl2 NM_031677 0.08 7.09E-03 Fhl4 NM_001013172 0.07 0.04 Filip1 NM_145682 0.1 9.83E-04 Fis1 ENSRNOT00000001924 -0.13 5.84E-08 Fjx1 ENSRNOT00000007077 0.16 2.24E-06 Fkbp2 ENSRNOT00000028725 -0.36 0 Fkbp8 NM_001037180 -0.15 1.11E-03 Fkrp NM_001025678 0.18 1.99E-07 Fktn DV724695 0.09 2.94E-03 Flnb ENSRNOT00000012796 0.15 7.60E-03 Flrt3 ENSRNOT00000006454 -0.19 3.35E-03 Fmr1 NM_052804 0.09 7.61E-03 Fnbp1l NM_001039609 -0.28 8.67E-05 Fndc3a AI599269 0.1 0.02 Fnta NM_012847 0.06 3.45E-03 Fos NM_022197 0.12 8.29E-03 Foxd4 ENSRNOT00000020763 -0.16 1.63E-03 Foxj3 ENSRNOT00000011683 -0.09 0.01 Foxn3 XM_001065120 -0.24 0.04 Foxo3a ENSRNOT00000000327 -0.16 4.07E-04 Foxp2 ENSRNOT00000060704 -0.12 0.02 Freq g11403202 -0.1 0.05 Frmd8 NM_001008348 -0.09 0.03 Frrs1 XM_001073918 0.1 7.62E-03 Fstl3 ENSRNOT00000012578 -0.13 4.09E-03 Fstl4 ENSRNOT00000008692 -0.13 0.01 Ftsj3 NM_001012014 0.09 2.67E-04 Fubp3 703973695J1 -0.08 6.08E-03 Fuk ENSRNOT00000024091 0.13 6.80E-05 Fusip1 NM_001025738 -0.2 4.30E-04 Fut8 NM_001002289 0.24 1.41E-11 Fut9 NM_053465 0.32 5.83E-15 Fxc1 NM_053371 0.1 1.95E-05 Fxr1 BC099129 0.21 4.57E-05 Fyttd1 XM_001081958 -0.2 5.63E-19 Fzd3 NM_153474 0.07 0.04 G0s2 NM_001009632 -0.87 7.07E-10 G3bp1 704304832H1 -0.13 2.61E-05 G6pc3 NM_176077 0.11 0.02 Gab2 NM_053417 -0.12 0.03 Gabbr2 AF109405 -0.1 0.04 Page 219 of 288 Diabetes

Gad1 NM_017007 -0.39 1.34E-04 Gadd45g NM_001077640 -0.13 5.62E-06 Gak NM_031030 0.1 1.68E-03 Galk2 NM_001013919 0.12 1.50E-05 Galnt1 ENSRNOT00000022117 0.08 3.81E-03 Galnt14 NM_001012109 0.11 5.15E-05 Galnt2 g11660372 0.07 0.02 Galnt5 NM_031796 -0.11 0.03 Galnt7 BF397407 0.24 1.85E-05 Galr2 NM_019172 -0.12 5.64E-11 Galt NM_001013089 -0.06 0.05 Ganab ENSRNOT00000026794 0.05 0.03 Gap43 NM_017195 0.13 9.31E-12 Garnl4 ENSRNOT00000042954 -0.31 2.86E-04 Gars ENSRNOT00000014780 0.08 8.46E-06 Gart ENSRNOT00000061322 0.13 1.09E-06 Gas7 NM_053484 -0.24 1.21E-09 Gata4 NM_144730 -0.13 0.02 Gatad1 BF418861 0.1 3.63E-04 Gatc ENSRNOT00000001536 0.1 2.74E-04 Gatm NM_031031 0.3 1.09E-39 Gba2 ENSRNOT00000022002 0.14 8.75E-10 Gbf1 CK226550 0.11 8.28E-06 Gca ENSRNOT00000009697 0.1 0.04 Gcat NM_001024277 0.19 1.44E-03 Gcgr NM_172092 -0.28 9.14E-05 Gck NM_012565 -0.12 1.14E-08 Gcnt3 NM_173312 -0.09 0.05 Gdap1l1 BP466301 -0.07 4.80E-03 Gdap2 NM_001013201 0.11 7.32E-03 Gde1 NM_032615 0.13 2.28E-09 Gdi2 NM_017276 0.04 0.02 Gem XM_232788 0.2 1.04E-22 Gemin4 XM_001080744 0.1 1.16E-03 Gemin6 NM_001009466 0.08 1.72E-03 Gemin7 ENSRNOT00000040934 0.06 0.02 Gfm1 NM_053625 0.07 8.56E-03 Gfm2 BC091392 -0.11 3.42E-05 Gfra1 NM_012959 0.11 5.15E-03 Ggcx BC100621 0.17 1.25E-05 Ggt7 NM_130423 0.13 3.37E-03 Ghitm NM_001005908 0.08 3.76E-07 Gigyf1 ENSRNOT00000001912 -0.07 0.05 Gins3 ENSRNOT00000015795 0.1 2.87E-03 Git2 CV797035 -0.12 7.19E-07 Glb1l2 ENSRNOT00000037790 0.08 0.03 Glce ENSRNOT00000038641 0.12 1.83E-04 Diabetes Page 220 of 288

Gle1 NM_001025731 -0.04 0.03 Glg1 BU759417 0.15 3.62E-03 Glmn ENSRNOT00000061583 0.12 1.65E-03 Glod4 NM_001014227 0.06 8.81E-03 Glrx1 NM_022278 -0.13 3.87E-05 Glrx5 ENSRNOT00000005781 0.08 0.02 Gls CB324591 0.26 2.24E-09 Glt1d1 XM_001073476 -0.07 0.05 Glt25d1 CK365279 0.09 0.01 Glt8d1 NM_001007683 0.08 8.27E-03 Glt8d3 ENSRNOT00000006960 0.17 2.57E-11 Gltpd1 NM_001007703 0.14 3.12E-04 Glud1 BU946684 0.04 0.05 Glul NM_017073 -0.11 7.04E-07 Gluld1 NM_181383 -0.06 0.04 Gmcl1 NM_001033931 0.17 9.46E-12 Gmeb2 NM_031803 -0.12 0.02 Gmfg NM_181091 0.13 1.02E-07 Gmppb BF407611 0.13 1.28E-04 Gmpr NM_057188 0.1 0.04 Gna11 NM_031033 0.22 5.26E-10 Gna12 NM_031034 -0.14 1.18E-04 Gna14 NM_001013151 0.27 8.04E-08 Gnai1 DV713743 0.08 3.37E-03 Gnai3 NM_013106 -0.14 1.94E-05 Gnb1 ENSRNOT00000022649 -0.39 1.05E-12 Gnb5 NM_031770 0.08 0.05 Gne NM_053765 0.1 0.02 Gng10 NM_053660 0.09 8.15E-06 Gng12 ENSRNOT00000007403 0.14 3.44E-03 Gng3 ENSRNOT00000026539 -0.15 0.01 Gng7 DQ120497 0.16 5.91E-04 Gnl2 NM_001025736 0.05 0.02 Gnpda2 ENSRNOT00000002992 0.07 0.01 Gns ENSRNOT00000006566 0.07 2.19E-03 Golim4 ENSRNOT00000037115 0.14 3.40E-05 Golsyn ENSRNOT00000005584 0.13 4.43E-03 Golt1a ENSRNOT00000003918 0.1 1.10E-06 Golt1b XM_342782 0.08 2.11E-03 Gorasp2 NM_001007720 0.05 0.02 Gosr2 NM_031685 -0.07 5.25E-04 Got1 NM_012571 0.07 1.17E-04 Gpaa1 NM_001004240 0.12 0.03 Gpbp1 ENSRNOT00000036658 0.09 3.55E-04 Gpc4 NM_001014108 0.07 0.02 Gpd1 NM_022215 -0.13 0.01 Gpd2 NM_012736 -0.19 2.35E-06 Page 221 of 288 Diabetes

Gpm6b NM_138846 0.14 1.06E-04 Gpr107 ENSRNOT00000037742 0.12 5.31E-05 Gpr128 XM_001059246 0.52 3.23E-03 Gpr137b AI180008 0.11 0.01 Gpr137c XM_001069888 -0.12 0.02 Gpr149 NM_138891 0.11 0.01 Gpr180 NM_001006994 0.17 4.39E-11 Gpr27 NM_023099 -0.28 7.31E-07 Gpr56 NM_152242 -0.12 0.04 Gpr85 g11402451 0.38 3.26E-21 Gpr89 ENSRNOT00000000106 0.13 1.90E-06 Gprasp1 NM_134386 0.07 0.03 Gprasp2 ENSRNOT00000004260 0.09 1.61E-05 Gprc5b ENSRNOT00000021441 0.13 0.03 Gpsm2 ENSRNOT00000016250 0.08 8.57E-03 Gramd1b ENSRNOT00000009685 0.11 0.02 Gramd3 BI281497 0.13 4.00E-04 Grb10 704272971J1 0.12 3.77E-04 Grb14 NM_031623 0.13 5.68E-05 Grb7 NM_053403 -0.15 1.51E-04 Grhpr ENSRNOT00000051445 0.08 2.54E-03 Gria2 M38061 0.42 8.53E-10 Grm2 ENSRNOT00000017607 -0.22 3.16E-04 Grpel1 NM_024487 0.08 5.52E-04 Gsbs NM_153467 -0.09 0.03 Gsdmd ENSRNOT00000045475 -0.1 0.02 Gsk3b NM_032080 -0.1 3.13E-04 Gsn NM_001004080 0.12 0.04 Gspt2 XM_001057027 0.16 5.19E-10 Gstk1 NM_181371 0.15 2.70E-04 Gstm1 NM_017014 0.14 1.77E-03 Gstm3 NM_031154 0.14 2.28E-03 Gstt1 NM_053293 -0.08 0.01 Gstt2 NM_012796 -0.18 7.33E-03 Gtdc1 CN542765 -0.1 9.93E-03 Gtf2a1 NM_022208 0.06 8.91E-03 Gtf2b NM_031041 0.08 3.34E-04 Gtf2e1 ENSRNOT00000003513 0.11 7.68E-08 Gtf2f1 NM_001007711 0.12 1.81E-06 Gtf2i NM_001001512 -0.08 1.89E-03 Gtf2ird1 DQ294702 -0.17 5.55E-04 Gtf3c2 NM_001025120 0.07 0.03 Gtf3c3 ENSRNOT00000002864 -0.12 1.34E-07 Gtf3c4 CB583374 0.13 6.14E-06 Gtf3c5 CB720398 0.06 0.05 Gtf3c6 ENSRNOT00000000716 0.09 5.40E-07 Gtpbp10 NM_001100815 0.13 1.16E-04 Diabetes Page 222 of 288

Gucy1a2 NM_023956 0.08 0.03 Gucy1b3 NM_012769 0.16 4.38E-12 Gucy2c NM_013170 0.24 1.62E-10 Gusb NM_017015 -0.29 2.66E-19 Gyltl1b NM_199107 0.1 2.57E-06 H1f0 NM_012578 -0.1 3.35E-03 H2afx ENSRNOT00000059715 0.12 7.20E-08 H2afy NM_017182 -0.09 1.65E-04 H2afz NM_022674 -0.5 0 Habp4 NM_001079940 0.29 2.71E-22 Hadh NM_057186 0.04 0.03 Hadha NM_130826 -0.07 6.78E-03 Hagh NM_033349 0.07 7.43E-04 Hap1 NM_024133 -0.15 4.33E-04 Harbi1 ENSRNOT00000023237 -0.11 0.03 Hat1 NM_001009657 0.06 0.03 Hbegf NM_012945 -0.36 3.86E-05 Hbp1 NM_013221 -0.17 3.37E-04 Hbs1l NM_001011934 -0.15 1.47E-08 Hcca2 ENSRNOT00000027195 0.07 8.08E-03 Hcfc2 NM_001008357 -0.07 0.02 Hdac3 NM_053448 -0.16 1.35E-16 Hddc3 ENSRNOT00000016445 0.12 4.36E-10 Hdhd2 ENSRNOT00000051857 -0.1 1.43E-03 Hdhd3 ENSRNOT00000020380 0.13 4.21E-05 Hdlbp NM_172039 0.05 0.03 Heatr3 ENSRNOT00000020793 0.16 3.97E-03 Heca ENSRNOT00000036663 -0.08 0.03 Hel308 BC086609 0.17 2.18E-06 Helb ENSRNOT00000038147 0.07 0.03 Hemk1 ENSRNOT00000020781 0.1 7.26E-04 Herpud1 NM_053523 -0.17 0.03 Herpud2 NM_001024988 0.07 0.04 Hgd NM_001012145 0.13 0.01 Hiatl1 XM_001060279 -0.14 5.02E-10 Hibadh NM_022243 -0.39 0 Higd1a AY062253 0.13 0.05 Hint3 ENSRNOT00000019047 0.1 2.55E-03 Hip1 XM_001071106 0.11 0.01 Hip1r ENSRNOT00000001461 -0.14 0.04 Hip2 BQ205283 0.06 9.19E-04 Hist1h2bp ENSRNOT00000049626 -0.07 0.02 Hist2h2be ENSRNOT00000028770 -0.12 0.03 Hist2h4_predicted ENSRNOT00000040210 0.11 1.59E-03 Hivep2 NM_024137 -0.18 1.24E-03 Hmg20a ENSRNOT00000022976 0.16 2.70E-03 Hmgb2l1 ENSRNOT00000018692 -0.24 1.45E-04 Page 223 of 288 Diabetes

Hmgb3 ENSRNOT00000015044 -0.09 0.05 Hmgcl NM_024386 0.11 3.76E-03 Hmox2 J05405 0.08 0.02 Hn1 CK603822 -0.27 2.65E-21 Hn1l NM_001013182 0.05 7.51E-03 Hnrnpa1 NM_017248 -0.12 2.37E-06 Hnrnpr NM_175603 -0.13 1.60E-08 Hnrnpu ENSRNOT00000046781 -0.24 4.03E-17 Hnrpa3 NM_198132 0.09 5.99E-03 Hnrpd NM_024404 -0.05 2.01E-03 Hnrpdl NM_001033696 -0.06 0.03 Hnrph1 NM_080896 -0.16 2.05E-14 Hnrpm NM_053876 -0.16 4.69E-24 Homer1 NM_031707 -0.09 0.04 Homer2 NM_053309 0.26 7.04E-04 Homer3 BF283379 -0.08 0.04 Homez NM_152849 -0.14 9.95E-05 Hoxa10 ENSRNOT00000036394 0.13 2.61E-03 Hoxa5 BE107303 -0.1 5.63E-03 Hoxb13 ENSRNOT00000009934 0.11 1.51E-04 Hoxb9 NM_001100497 0.07 0.02 Hpca NM_017122 -0.26 5.05E-03 Hpcal1 NM_017356 -0.1 6.68E-03 Hpgd NM_024390 -0.16 1.44E-06 Hps1 AF333326 -0.13 9.06E-03 Hs1bp3 ENSRNOT00000007991 0.13 0.03 Hsbp1 NM_173119 -0.22 9.29E-12 Hsd17b1 NM_012851 -0.1 5.44E-03 Hsd17b10 NM_031682 0.1 9.96E-05 Hsd17b12 NM_032066 0.14 9.26E-09 Hsd17b7 NM_017235 0.2 5.00E-03 Hsdl2 NM_001025697 -0.28 1.36E-20 Hspa12a ENSRNOT00000024548 -0.19 2.34E-03 Hspa4 BQ200546 0.07 2.17E-03 Hspa4l ENSRNOT00000015474 0.08 0.04 Hspb6 NM_138887 0.11 6.87E-03 Hspbap1 NM_134419 0.07 0.02 Hspbp1 NM_139261 0.06 4.47E-03 Hspd1 NM_022229 0.03 0.03 Hspe1 NM_012966 -0.04 0.04 Hsph1 NM_001011901 0.1 1.30E-03 Htatip NM_001005872 -0.11 7.48E-05 Htatip2 ENSRNOT00000036258 0.04 0.02 Htatsf1 XM_001058638 0.06 0.04 Htr5b ENSRNOT00000003441 0.08 0.03 Htt BF399612 -0.08 0.02 Hus1 ENSRNOT00000006852 0.12 4.67E-04 Diabetes Page 224 of 288

Hyal3 ENSRNOT00000021526 0.12 0.05 Hyal4 ENSRNOT00000009458 -0.13 4.16E-03 Hypk ENSRNOT00000021091 0.11 2.24E-04 Icam5 ENSRNOT00000028096 -0.05 0.05 Ick BQ211190 0.11 3.12E-03 Id1 NM_012797 0.38 4.53E-05 Id3 NM_013058 0.31 5.95E-05 Id4 NM_175582 0.05 8.99E-03 Idh1 NM_031510 -0.05 0.01 Idh2 NM_001014161 0.07 0.01 Idh3a 703915184J1 0.12 7.62E-05 Idi1 NM_053539 -0.13 1.31E-04 Ifi35 NM_001009625 -0.14 1.22E-07 Ifi47 NM_172019 -0.22 3.87E-09 Ifngr1 NM_053783 0.11 3.57E-04 Ifngr2 AI598699 0.12 4.85E-05 Ifrd1 NM_019242 0.05 0.05 Ift122 ENSRNOT00000014733 -0.21 5.49E-20 Ift20 ENSRNOT00000011795 0.1 7.14E-07 Ift52_predicted XM_001069325 0.08 2.69E-05 Ift57 XM_001058583 0.11 5.38E-04 Ift80 NM_001013911 0.08 0.02 Igfbp1 NM_013144 -0.15 3.47E-03 Igfbp5 ENSRNOT00000023530 0.18 2.28E-04 Ik NM_001005537 -0.07 8.59E-03 Ikbkb BI291377 -0.14 2.92E-08 Il13ra1 NM_145789 0.18 9.45E-07 Il15 NM_013129 -0.3 1.16E-03 Il17rb ENSRNOT00000020823 -0.23 0.05 Il1r2 NM_053953 -0.1 0.01 Il1rap BC097339 0.17 4.10E-03 Il20ra ENSRNOT00000050656 -0.2 3.87E-07 Il33 CK476749 0.07 0.03 Il3ra NM_139260 -0.07 0.04 Il6ra NM_017020 -0.17 2.22E-04 Il6st NM_001008725 -0.21 1.85E-08 Il8ra NM_019310 -0.1 0.02 Ilf3 CA511643 -0.15 9.57E-03 Ilk NM_133409 -0.05 0.02 Imp3 ENSRNOT00000023456 -0.4 9.29E-29 Imp4 NM_001009700 0.1 6.51E-05 Impa1 NM_032057 0.09 2.56E-06 Impdh1 ENSRNOT00000027173 0.11 0.02 Incenp BF418429 0.12 2.01E-04 Ing4 NM_001079887 -0.23 4.19E-35 Inpp4a NM_031002 -0.12 8.40E-03 Inpp5a XM_001058238 0.27 1.33E-09 Page 225 of 288 Diabetes

Inpp5f DV718624 -0.13 2.42E-07 Insig2 ENSRNOT00000003391 0.07 0.02 Insr NM_017071 0.14 2.56E-04 Ints9 ENSRNOT00000018071 0.11 2.24E-03 Ipo11 BC092638 0.07 3.07E-03 Ipo7 ENSRNOT00000014002 -0.2 7.81E-15 Ipo9 BC099203 0.06 0.02 Iqgap1 ENSRNOT00000018021 -0.12 9.08E-03 Irak1 704245796J1 0.06 0.05 Irf1 NM_012591 -0.2 9.67E-05 Irgq BF396086 0.09 9.33E-04 Iscu ENSRNOT00000000890 0.04 0.03 Isg20 NM_001008510 -0.15 9.28E-04 Isg20l1 XM_001064302 0.12 0.03 Isl1 NM_017339 -0.15 7.64E-06 Isoc1 NM_001014242 -0.38 7.20E-36 Itch NM_001005887 -0.13 4.87E-03 Itfg1 NM_133557 0.09 1.94E-06 Itga1 NM_030994 0.13 0.04 Itga4 ENSRNOT00000006880 0.19 3.13E-04 Itga6 XM_001059465 0.42 1.42E-05 Itm2b CO554226 -0.07 6.24E-03 Itpa ENSRNOT00000028838 0.09 5.42E-03 Itpk1 ENSRNOT00000010656 -0.1 3.58E-03 Itpr1 M64698 -0.14 0.01 Itsn2 XM_233945 0.25 0.02 Ivd NM_012592 0.11 0.01 Ivns1abp ENSRNOT00000059863 0.05 3.71E-03 Jag1 NM_019147 0.28 1.63E-03 Jag2 AW533028 -0.11 0.04 Jak1 ENSRNOT00000015438 0.07 4.38E-04 Jak2 NM_031514 0.09 2.79E-03 Jakmip1 NM_001033894 -0.14 6.14E-03 Jarid1b EV778094 -0.17 6.90E-03 Jazf1 ENSRNOT00000039580 0.16 3.33E-09 Jmjd2c ENSRNOT00000009083 0.06 0.02 Josd2 ENSRNOT00000026379 -0.13 9.05E-03 Jph1 ENSRNOT00000008153 -0.06 0.04 Jtb NM_019213 0.08 5.18E-05 Jub NM_053503 -0.09 0.03 Jund NM_138875 -0.09 2.79E-03 Jundm2 NM_053894 -0.06 0.02 Kalrn NM_032062 -0.19 2.02E-05 Kars NM_001006967 0.08 1.82E-03 Katna1 NM_001004217 0.12 1.79E-04 Kbtbd4 ENSRNOT00000012876 0.04 0.04 Kbtbd8 ENSRNOT00000017889 0.1 0.05 Diabetes Page 226 of 288

Kcna2 NM_012970 0.13 0.01 Kcna4 NM_012971 0.29 3.17E-24 Kcnab3 NM_031652 -0.38 1.65E-03 Kcnc1 NM_012856 -0.4 9.68E-04 Kcne2 NM_133603 -0.19 5.43E-04 Kcng2 XM_001058122 -0.08 4.69E-03 Kcnh1 NM_031742 0.23 5.55E-13 Kcnj11 AB043638 -0.29 6.37E-10 Kcnj3 NM_031610 0.07 0.02 Kcnk2 NM_172042 0.2 2.61E-03 Kcnk6 NM_053806 0.16 4.64E-03 Kcnma1 AJ517197 0.14 5.79E-06 Kcnmb2 NM_176861 -0.31 2.17E-04 Kcnn1 NM_019313 -0.13 9.00E-03 Kcnq5 AF525937 0.1 4.23E-03 Kctd11 XM_001079638 -0.09 4.75E-03 Kctd15 ENSRNOT00000028698 -0.12 2.68E-03 Kctd2 ENSRNOT00000032608 -0.16 8.90E-06 Kctd20 CB731938 0.12 2.02E-03 Kctd3 AY724501 0.09 2.10E-03 Kctd9 XM_001068535 0.12 5.14E-04 Kdelr2 NM_001013122 0.09 6.28E-04 Kdsr ENSRNOT00000003728 -0.15 4.56E-03 Ke2 NM_212506 0.09 3.38E-03 Keap1 AI231764 0.09 0.02 Kidins220 NM_053795 0.07 0.02 Kif12 ENSRNOT00000010040 -0.1 1.81E-03 Kif15 NM_181635 -0.08 0.03 Kif1a g8497651 -0.09 7.30E-04 Kif20a ENSRNOT00000033784 -0.14 1.06E-06 Kif21a ENSRNOT00000038946 -0.27 6.07E-13 Kif23 ENSRNOT00000037028 -0.14 1.90E-03 Kif5b 704298894J1 0.06 1.34E-03 Kifap3 XM_001070739 0.1 2.17E-05 Kirrel g8509820 0.11 0.01 Kit NM_022264 -0.48 3.16E-12 Kitl AB105879 -0.58 2.02E-05 Klc4 NM_001009601 -0.16 2.85E-04 Klf10 NM_031135 -0.26 3.94E-06 Klf4 BC085720 0.29 5.15E-07 Klf7 ENSRNOT00000017901 -0.12 7.63E-04 Klf9 AI113128 -0.15 6.07E-06 Klhl18 ENSRNOT00000056141 0.11 5.43E-04 Klhl20 ENSRNOT00000003851 0.15 1.31E-04 Klhl24 NM_181473 -0.4 1.66E-41 Klhl5 NM_001047093 -0.13 0.01 Klhl8 AW527566 -0.13 1.10E-04 Page 227 of 288 Diabetes

Kpna1 NM_198726 0.12 1.25E-03 Kpna4 DY472822 0.08 1.44E-03 Kpna6 NM_001015029 0.11 0.04 Krcc1 NM_001009413 0.11 3.16E-06 Kremen1 NM_053649 -0.07 0.05 Krt18 NM_053976 -0.23 0.01 Ktelc1 ENSRNOT00000051428 0.14 2.34E-08 Kti12 NM_001044288 0.07 3.44E-04 L2hgdh ENSRNOT00000006473 0.13 0.05 Lace1 NM_001037656 -0.1 0.04 Lactb2 NM_001024247 0.13 2.21E-09 Lad1 XM_001063663 -0.21 5.65E-04 Lage3 ENSRNOT00000056312 0.07 0.03 Lamc1 g11671089 0.22 2.80E-07 Lap3 NM_001011910 0.13 1.20E-09 Large ENSRNOT00000018434 -0.06 0.05 Las1l ENSRNOT00000016042 0.11 2.34E-06 Lasp1 NM_032613 -0.07 0.01 Lass2 CF110567 -0.23 6.06E-16 Lcat NM_017024 -0.24 0.05 Lcmt1 NM_199405 0.1 6.41E-04 Lcp1 NM_001012044 -0.07 0.05 Lcp2 NM_130421 0.1 0.02 Ldb1 ENSRNOT00000025025 -0.14 0.02 Ldhb NM_012595 0.57 3.19E-16 Leng1 ENSRNOT00000017546 0.15 1.92E-11 Leng4 XM_001056203 0.17 5.78E-07 Leng9 ENSRNOT00000025138 0.09 8.82E-03 Leprotl1 NM_001013188 -0.26 6.16E-13 Lgals8 BI289476 0.05 0.03 Lgr4 BQ206104 -0.09 9.45E-03 Limd1 CO568494 0.06 0.02 Limd2 NM_001025715 -0.48 0 Lin7a NM_053514 0.25 1.14E-04 Lingo4 ENSRNOT00000028292 -0.21 1.29E-04 Lins2 ENSRNOT00000018463 0.08 6.14E-03 Lipa g14924219 0.21 4.96E-04 Litaf ENSRNOT00000003412 -0.06 0.02 Llgl1 NM_152844 -0.16 2.42E-03 Lman1 NM_053886 0.12 6.44E-04 Lmbr1 ENSRNOT00000007189 0.15 0.02 Lmbrd2 ENSRNOT00000060018 0.14 0.02 Lmna BC062018 0.12 0.02 Lmnb1 NM_053905 -0.13 3.20E-04 Lmo4 NM_001009708 0.16 1.71E-04 Lmo7 NM_001001515 -0.12 0.04 Lnp 704152653J1 0.15 1.09E-07 Diabetes Page 228 of 288

LOC679811 XM_001054550 -0.13 3.82E-03 LOC679880 703890108J1 0.09 0.02 LOC680039 XM_001054238 0.07 0.03 LOC680133 ENSRNOT00000018640 0.06 2.15E-03 LOC680308 ENSRNOT00000014603 0.07 4.30E-03 LOC680426 ENSRNOT00000047305 0.15 0.03 LOC680445 XM_001074986 -0.13 1.15E-04 LOC680477 ENSRNOT00000020576 0.11 1.39E-03 LOC680734 ENSRNOT00000025213 0.05 0.05 LOC681086 XM_001060262 0.15 1.90E-08 LOC681162 ENSRNOT00000052379 -0.09 0.02 LOC681367 XM_001061427 0.07 6.14E-04 LOC685079 ENSRNOT00000030054 0.11 2.61E-04 LOC685144 ENSRNOT00000033162 0.07 8.62E-04 LOC685284 ENSRNOT00000013615 0.08 7.78E-04 LOC685569 XM_001063873 -0.1 0.04 LOC685634 ENSRNOT00000019224 0.12 3.24E-03 LOC685888 ENSRNOT00000035033 0.07 0.01 LOC686117 XM_001054906 -0.15 0.02 LOC688393 ENSRNOT00000006599 0.07 2.36E-04 LOC688558 ENSRNOT00000047859 0.12 2.47E-07 LOC689035 ENSRNOT00000012201 0.19 8.00E-05 LOC689176 ENSRNOT00000009759 -0.26 5.22E-04 LOC689226 CN541495 -0.24 5.65E-04 LOC689296 ENSRNOT00000029411 -0.11 5.68E-04 LOC689574 XM_001068230 0.12 7.94E-08 LOC689748 ENSRNOT00000018331 0.12 0.03 LOC689986 XM_001061679 -0.21 3.01E-04 LOC689996 ENSRNOT00000058976 0.12 0.04 LOC690164 ENSRNOT00000045644 0.1 0.03 LOC690208 XM_001080613 0.18 2.10E-04 LOC690303 ENSRNOT00000013725 0.06 0.04 LOC690470 ENSRNOT00000012214 -0.17 6.23E-06 LOC690538 ENSRNOT00000039410 0.07 0.04 LOC690769 ENSRNOT00000025716 0.05 0.04 LOC690965 XM_001076332 -0.22 4.05E-03 LOC691083 BG377843 0.07 0.04 LOC691862 XM_001080848 0.33 4.06E-32 LOC691903 ENSRNOT00000030146 -0.08 0.02 Lonrf1 ENSRNOT00000015142 -0.08 0.02 Lphn2 NM_134408 -0.11 8.05E-03 Lpin1 NM_001012111 -0.18 9.46E-04 Lppr4 NM_001001508 0.15 7.39E-08 Lrfn1 CK839525 0.05 0.04 Lrig1 ENSRNOT00000017384 0.1 0.02 Lrp11 ENSRNOT00000062020 -0.13 1.18E-07 Lrp6 ENSRNOT00000008486 0.15 1.17E-06 Page 229 of 288 Diabetes

Lrpap1 BC082020 0.13 7.23E-07 Lrrc1 NM_001014268 -0.07 8.53E-03 Lrrc16 ENSRNOT00000022266 0.1 0.03 Lrrc28 ENSRNOT00000033858 0.16 3.47E-04 Lrrc39 ENSRNOT00000020297 0.2 1.58E-07 Lrrc40 NM_001034926 0.06 5.89E-03 Lrrc42 NM_001025653 0.03 0.05 Lrrc44 CK595432 0.08 0.02 Lrrc47 ENSRNOT00000034284 -0.12 1.05E-04 Lrrc59 NM_001008280 0.15 6.14E-13 Lrrc8c NM_001037179 0.14 1.85E-06 Lrrfip1 NM_001014269 -0.32 1.53E-06 Lrrfip2 704319971J1 0.16 1.15E-04 Lrrn3 NM_030856 0.13 8.21E-05 Lsm1 ENSRNOT00000020721 0.14 2.35E-07 Lsm12 ENSRNOT00000028368 0.12 1.04E-03 Lsm14a XM_001079562 -0.07 0.02 Lsm3 ENSRNOT00000011557 0.09 1.41E-04 Lsm4 ENSRNOT00000026567 -0.36 0 Lsm5 XM_001059585 0.08 6.44E-03 Lsm7 ENSRNOT00000026551 0.09 6.60E-06 Lsm8 ENSRNOT00000011456 -0.37 2.11E-30 Ltbp1 NM_021587 -0.15 4.69E-03 Ltv1 NM_001014157 -0.06 1.18E-03 Luc7l CF978325 0.07 3.82E-03 Luc7l2 g14932623 -0.17 9.79E-12 Ly6g6c NM_001001969 -0.08 0.02 Lyn AF000300 0.13 6.63E-03 Lynx1 ENSRNOT00000007988 0.09 2.67E-03 Lypd1 NM_001007727 0.16 9.47E-05 Lypla2 NM_031342 0.07 7.32E-03 Lypla3 NM_001004277 0.17 2.54E-08 Lyplal1 ENSRNOT00000032865 0.08 9.77E-06 Lyrm1 ENSRNOT00000033673 0.15 1.87E-06 Lysmd1 NM_001024302 0.11 4.49E-07 Lysmd2 ENSRNOT00000014301 -0.08 1.78E-03 Lztfl1 NM_001024266 0.1 5.33E-05 Mad1l1 XM_001073997 0.07 3.32E-03 Mad2l1 AF257321 -0.13 1.43E-06 Mad2l1bp NM_001009699 0.15 3.07E-09 Maea NM_001008319 0.06 9.93E-04 Maf1 NM_001014085 -0.11 3.47E-05 Mafa ENSRNOT00000010084 -0.2 1.08E-03 Mafk NM_145673 -0.09 4.70E-03 Mageh1 NM_001013250 -0.21 1.42E-03 Magi1 NM_001030045 -0.11 3.47E-03 Magoh ENSRNOT00000017422 0.06 0.04 Diabetes Page 230 of 288

Mal2 NM_198786 0.12 2.20E-04 Maml3 CX570558 -0.09 0.05 Man2a1 g4136169 0.19 3.09E-07 Manba NM_001031655 0.16 5.40E-05 Maoa g4228850 0.15 3.72E-05 Map1lc3b NM_022867 0.05 0.03 Map2k1 NM_031643 0.09 3.45E-04 Map2k1ip1 AI411936 0.13 1.82E-04 Map2k4 702961974J1 0.12 7.61E-06 Map3k2 ENSRNOT00000018975 0.22 8.82E-04 Map3k3 ENSRNOT00000011406 -0.23 4.46E-28 Map4k3 XM_001055154 0.12 9.59E-04 Map4k5 CO389166 0.09 0.01 Mapbpip ENSRNOT00000026974 -0.07 5.00E-04 Mapk1 BM422632 -0.43 5.71E-03 Mapk3 NM_017347 -0.14 3.29E-04 Mapk8 BI297991 -0.17 1.25E-13 Mapkap1 NM_001011964 0.16 6.20E-04 Mapkapk2 NM_178102 -0.3 4.62E-11 Mapre1 NM_138509 -0.07 8.12E-03 Mapt NM_017212 -0.36 3.15E-23 Marcks ENSRNOT00000000707 0.07 0.05 Marcksl1 NM_030862 -0.14 8.53E-07 Mark3 NM_130749 -0.08 1.63E-03 Mat1a NM_012860 0.12 0.01 Matk NM_021859 -0.36 2.93E-09 Matn2 ENSRNOT00000008361 0.14 0.02 Matr3 NM_019149 -0.1 6.80E-06 Max BC099778 0.16 3.83E-17 Mbd3 ENSRNOT00000049170 -0.06 0.04 Mbip ENSRNOT00000011419 0.09 0.04 Mboat2 702960653J2 0.18 1.46E-08 Mbp NM_001025294 -0.2 0.04 Mcart1 NM_001024785 -0.2 1.58E-17 Mccc1 NM_001009653 0.13 3.55E-05 Mccc2 NM_001012177 0.18 1.32E-08 Mcee ENSRNOT00000021884 0.09 0.01 Mcf2l NM_053951 -0.19 3.08E-04 Mcfd2 NM_139253 0.17 7.91E-16 Mcl1 NM_021846 0.08 0.05 Mcm2 XM_001072364 -0.2 2.46E-20 Mcm5 ENSRNOT00000019677 -0.14 9.65E-05 Mcm6 ENSRNOT00000004969 -0.07 3.79E-04 Mcm8 ENSRNOT00000028897 -0.09 7.50E-03 Mcoln3 NM_001012059 -0.14 0.03 Mcts1 NM_001044237 0.08 5.60E-03 Mcts2 XM_001071410 0.1 7.26E-07 Page 231 of 288 Diabetes

Mdh2 NM_031151 0.06 2.96E-03 Mdk NM_030859 0.05 0.02 Mdn1 AI138044 0.1 0.01 Mdp1 ENSRNOT00000026914 0.12 3.01E-06 Me2 ENSRNOT00000049759 0.09 1.60E-05 Mea1 NM_001044286 0.12 1.44E-04 Mecr NM_017209 0.13 6.96E-06 Med1 EV762422 -0.17 2.54E-03 Med10 ENSRNOT00000023161 0.05 0.01 Med17 ENSRNOT00000014435 0.07 0.02 Med21 ENSRNOT00000002500 0.08 0.02 Med27 ENSRNOT00000019157 -0.07 1.50E-04 Med28 ENSRNOT00000004912 0.05 0.04 Med29 ENSRNOT00000026720 0.09 1.10E-03 Med30 ENSRNOT00000006480 0.15 3.64E-08 Med4 NM_001024256 0.12 8.00E-06 Med6 ENSRNOT00000009483 0.09 1.28E-03 Mel13 XM_001081379 0.08 0.02 Melk ENSRNOT00000018650 -0.41 1.59E-20 Memo1 CB757195 0.07 0.03 Mesdc2 NM_001008345 -0.09 1.91E-05 Met NM_031517 0.17 8.41E-06 Mettl10 ENSRNOT00000023121 0.17 1.55E-07 Mettl2 ENSRNOT00000008140 0.07 0.01 Mettl4 ENSRNOT00000037587 0.08 0.04 Mettl6 NM_001007623 0.09 4.24E-05 Mex3a ENSRNOT00000052079 -0.25 0.01 Mfap3 NM_001007609 0.07 0.05 Mfap3l NM_001012049 0.11 0.02 Mfhas1 ENSRNOT00000015203 0.23 1.01E-03 Mfsd1 ENSRNOT00000018489 0.1 4.20E-03 Mfsd2 ENSRNOT00000019080 0.14 1.01E-04 Mfsd9 ENSRNOT00000038915 0.1 6.81E-03 Mgat2 NM_053604 0.16 1.92E-10 Mgat3 NM_019239 -0.09 3.34E-04 Mgat4a NM_001012225 0.2 2.92E-05 Mgea5 NM_131904 -0.24 5.18E-13 Mgmt NM_012861 -0.06 0.05 Mgst1 NM_134349 0.1 1.10E-03 Micall2 XM_221956 -0.18 0.03 Mid1ip1 NM_206950 -0.12 9.27E-06 Mid2 ENSRNOT00000020145 0.12 0.03 Mier1 ENSRNOT00000009438 -0.17 1.02E-03 Mier3 ENSRNOT00000017571 0.07 0.05 Mif4gd NM_001014122 -0.19 2.80E-11 Mitd1 NM_001009714 0.08 0.02 Mkks NM_001008353 0.13 4.41E-05 Diabetes Page 232 of 288

Mknk2 NM_001011985 -0.33 1.28E-05 Mkrn2 NM_001008314 0.11 4.15E-04 Mlf1 ENSRNOT00000017143 0.17 1.63E-04 Mllt11 CV074114 0.11 3.15E-03 Mllt3 NM_053718 -0.08 0.05 Mlstd2 g8500382 0.07 9.50E-03 Mlxipl NM_133552 -0.12 0.02 Mmp17 ENSRNOT00000035881 -0.16 3.79E-03 Mmp28 704329605J1 0.09 0.02 Mnt ENSRNOT00000003933 -0.18 4.38E-03 Moap1 DY471633 0.1 3.58E-04 Mobkl1b NM_001033891 -0.18 7.16E-07 Mocs1 BC098067 0.09 4.82E-03 Mocs2 NM_001007633 0.14 1.71E-05 Mocs3 ENSRNOT00000039403 0.13 3.90E-07 Mon2 ENSRNOT00000045130 0.11 1.62E-05 Morc4 ENSRNOT00000034925 0.09 5.23E-03 Mphosph1 XM_001080017 -0.09 6.47E-03 Mphosph9 ENSRNOT00000049985 0.07 0.03 Mpp4 ENSRNOT00000038132 -0.09 0.04 Mpp6 703836882J1 0.09 0.01 Mras NM_012981 0.2 2.11E-05 Mrpl12 NM_001029900 0.08 1.22E-03 Mrpl13 NM_001006985 0.07 6.14E-04 Mrpl16 NM_001009647 0.1 2.83E-04 Mrpl17 NM_133539 0.1 2.33E-07 Mrpl18 ENSRNOT00000020064 0.12 6.07E-09 Mrpl19 NM_001029898 0.06 0.03 Mrpl21 ENSRNOT00000018848 0.06 0.02 Mrpl23 NM_022529 0.06 4.97E-03 Mrpl32 ENSRNOT00000021433 -0.09 5.72E-04 Mrpl35 ENSRNOT00000012021 0.11 2.82E-05 Mrpl37 NM_001004235 0.06 0.02 Mrpl42 XM_001077569 0.16 0.02 Mrpl46 NM_001013068 0.07 1.16E-03 Mrpl47 NM_001037183 0.13 5.52E-05 Mrpl49 NM_001047883 0.12 3.15E-03 Mrpl52 ENSRNOT00000060193 0.05 0.04 Mrpl53 ENSRNOT00000011427 0.06 4.05E-03 Mrpl54 ENSRNOT00000027737 -0.05 0.02 Mrps11 ENSRNOT00000025008 -0.32 1.67E-30 Mrps18c ENSRNOT00000002962 0.12 1.51E-06 Mrps2 g4132969 0.12 1.19E-04 Mrps25 NM_001025408 0.16 6.14E-05 Mrps27 ENSRNOT00000023286 -0.11 0.02 Mrps34 ENSRNOT00000021075 -0.06 0.04 Mrps5 ENSRNOT00000020451 0.06 3.32E-03 Page 233 of 288 Diabetes

Mrps7 ENSRNOT00000005089 0.13 3.42E-06 Mrps9 BP503628 0.07 1.31E-03 Mrs2 NM_024001 0.11 3.52E-06 Mrto4 ENSRNOT00000024326 0.15 2.75E-05 Ms4a8a XM_001075127 -0.1 3.38E-03 Msh2 NM_031058 -0.05 0.03 Msi1 NM_148890 -0.14 6.92E-03 Msi2 BF388985 -0.45 0 Msl2l1 g8500991 -0.11 0.04 Msl31 NM_001014111 -0.25 0 Msrb2 NM_001031660 -0.2 1.76E-11 Msto1 ENSRNOT00000027579 0.11 1.09E-03 Mt1a NM_138826 0.69 5.23E-05 Mta3_predicted ENSRNOT00000006313 -0.05 0.03 Mtap NM_001047867 0.13 1.65E-03 Mtap7 XM_214968 -0.09 4.41E-03 Mtch2 BQ211309 -0.06 7.54E-03 Mtdh AI230755 -0.11 2.58E-04 Mterfd1 NM_199387 0.04 0.04 Mterfd2 NM_001037209 0.08 1.96E-04 Mtf1 ENSRNOT00000031928 0.08 0.05 Mtf2 BC093403 -0.16 2.08E-05 Mtfr1 g14960812 -0.19 9.89E-03 Mthfs NM_001009349 -0.57 0 Mtm1 NM_001013047 0.09 2.00E-04 Mtmr1 704181690J1 -0.14 0.04 Mtmr7 ENSRNOT00000015625 0.06 0.01 Mtnr1b ENSRNOT00000011883 -0.07 0.04 Mto1 ENSRNOT00000057138 -0.15 6.86E-08 Mtp18 NM_001006960 0.07 0.02 Mtpn ENSRNOT00000015808 0.08 2.66E-03 Mtrr NM_001039003 0.11 8.12E-04 Mtx2 NM_001008286 0.1 8.81E-06 Mum1l1 ENSRNOT00000041044 0.27 8.06E-03 Mustn1 NM_181368 0.14 1.78E-04 Mut ENSRNOT00000044594 0.13 2.84E-04 Mvp BP466524 0.06 0.05 Mxd3 NM_145773 -0.23 3.57E-06 Mxi1 NM_013160 -0.17 8.02E-04 Myadm NM_183332 0.1 4.22E-03 Mybbp1a NM_031668 0.08 3.02E-03 Myc NM_012603 -0.16 3.71E-04 Mycbp2 ENSRNOT00000014583 -0.26 2.21E-04 Mycn NM_001013096 -0.13 4.54E-05 Myd88 NM_198130 -0.11 6.76E-05 Myeov2 CB313601 0.12 2.15E-05 Myo15 ENSRNOT00000023018 -0.15 0.05 Diabetes Page 234 of 288

Myo16 g8493745 -0.14 0.01 Myo1d NM_012983 0.11 7.81E-06 Myo5a NM_022178 -0.09 0.04 Myo5b NM_017083 0.23 5.68E-07 Myo9a NM_134335 -0.11 6.50E-04 Mysm1 ENSRNOT00000039554 0.11 8.04E-03 N4bp2l1 ENSRNOT00000061446 -0.21 4.12E-03 N6amt1 XM_213675 -0.09 0.04 N6amt2 ENSRNOT00000013434 0.05 0.04 Nab1 CK601822 0.24 2.30E-18 Naca ENSRNOT00000003550 -0.06 7.47E-03 Nadsyn1 NM_181480 0.1 0.02 Naf1 NM_001024772 0.14 1.14E-04 Naga NM_001012120 0.1 4.36E-03 Nagk NM_001037768 0.13 1.91E-03 Nagpa XM_340751 0.11 1.64E-04 Nanp NM_001009409 0.09 7.71E-03 Nap1l1 703942719J1 -0.32 2.98E-22 Nap1l2 NM_001024789 -0.12 7.84E-05 Napa NM_080585 0.07 0.05 Narf NM_001039207 0.11 0.04 Narg1 g3728042 0.1 5.46E-03 Nars BQ204312 0.05 9.99E-03 Nat1 BP480680 0.11 8.54E-03 Nat13 ENSRNOT00000059664 0.13 8.65E-12 Nat2 NM_053854 0.08 3.94E-03 Nat5 XM_001055084 0.11 2.13E-06 Nbr1 NM_001024765 -0.1 4.03E-03 Ncam1 CB791294 0.1 2.62E-04 Ncbp1 NM_001014785 -0.05 0.01 Ncf1 DQ294710 -0.12 0.01 Ncf2 NM_001100984 0.11 0.01 Nck2 ENSRNOT00000023029 0.05 0.03 Nckap1 D84346 -0.09 0.04 Ncoa3 ENSRNOT00000007768 0.06 3.40E-03 Ncoa4 NM_001034008 0.05 0.02 Ncoa5 ENSRNOT00000024214 -0.05 0.05 Ncor1 ENSRNOT00000057682 0.05 0.01 Ncor2 ENSRNOT00000001334 -0.18 0.02 Ndc80 ENSRNOT00000018644 -0.1 1.69E-03 Nde1 NM_053347 0.07 0.01 Ndel1 NM_133320 0.12 2.57E-04 Ndfip1 NM_001013059 -0.06 3.40E-03 Ndfip2 BG671972 0.14 1.21E-04 Ndg2 NM_001007008 0.1 3.28E-03 Ndnl2 ENSRNOT00000022069 0.12 2.89E-05 Ndrg1 NM_001011991 -0.39 0 Page 235 of 288 Diabetes

Ndrg4 NM_031967 -0.3 1.17E-04 Ndst2 ENSRNOT00000035100 0.11 2.78E-03 Ndufa2 ENSRNOT00000023811 0.13 6.33E-08 Ndufa5 NM_012985 0.08 1.28E-04 Ndufa7 ENSRNOT00000009425 0.09 7.38E-04 Ndufa8 NM_001047862 0.1 7.96E-07 Ndufaf2 ENSRNOT00000060867 0.09 0.01 Ndufb5 ENSRNOT00000016051 -0.04 0.03 Ndufb7 ENSRNOT00000035890 0.08 1.83E-04 Ndufb8 ENSRNOT00000019039 0.03 0.05 Ndufc1 ENSRNOT00000058190 0.08 1.86E-03 Ndufs3 ENSRNOT00000012425 0.08 1.25E-03 Ndufs7 NM_001008525 0.06 0.02 Ndufs8 ENSRNOT00000023526 0.05 0.03 Ndufv1 NM_001006972 -0.38 0 Ndufv2 NM_031064 0.07 7.52E-04 Ndufv3l CK482214 -0.07 2.39E-03 Necap1 NM_001029919 -0.25 8.63E-09 Nedd4l ENSRNOT00000023890 0.14 1.42E-03 Nedd8 NM_138878 0.08 5.25E-03 Nedd9 NM_001011922 0.12 7.28E-03 Nefl NM_031783 0.17 2.65E-04 Nefm NM_017029 0.26 2.53E-20 Neil3 ENSRNOT00000015623 -0.08 0.04 Nek4 ENSRNOT00000024296 0.13 2.06E-04 Nell1 NM_031069 -0.09 0.02 Net1 NM_001039023 0.07 0.02 Neto2 ENSRNOT00000021739 0.06 0.03 Neu1 NM_031522 0.22 9.87E-06 Neu2 NM_017130 0.08 0.02 Neu3 NM_054010 -0.11 4.19E-03 Neurl ENSRNOT00000054696 -0.13 0.01 Nf1 BF409773 0.15 0.03 Nfam1 XM_343297 -0.1 2.26E-03 Nfatc2ip NM_001007692 -0.25 2.75E-06 Nfe2l1 BF560692 0.09 3.46E-03 Nfib NM_031566 -0.28 2.01E-06 Nfkbia ENSRNOT00000009894 -0.13 8.84E-03 Nfkbib NM_030867 0.15 4.38E-03 Nfya NM_012865 -0.09 0.04 Nfyb NM_031553 0.13 4.06E-04 Nfyc NM_012866 -0.05 0.04 Ngdn ENSRNOT00000024337 0.09 4.00E-03 Ngly1 NM_001014136 -0.2 5.22E-17 Niban NM_022242 0.18 1.75E-03 Ninj1 NM_012867 0.07 0.04 Nip7 NM_138847 0.09 0.02 Diabetes Page 236 of 288

Nipa2 ENSRNOT00000018028 0.12 4.05E-03 Nipsnap1 CO812497 0.06 0.03 Nipsnap3a NM_001009422 0.07 4.46E-05 Nisch BP485260 -0.1 0.03 Nkap CV108587 -0.17 4.17E-03 Nkiras1 ENSRNOT00000011438 0.15 2.21E-04 Nkiras2 ENSRNOT00000024543 -0.38 2.67E-37 Nkx2-2 ENSRNOT00000017364 0.09 1.53E-04 Nle1 ENSRNOT00000011320 0.05 0.04 Nlf2 ENSRNOT00000012048 0.1 4.14E-05 Nlgn1 NM_053868 0.24 0.01 Nlgn3 g8511583 -0.15 0.02 Nlk AI231394 0.2 4.74E-05 Nln NM_053970 -0.13 1.05E-04 Nmd3 ENSRNOT00000012417 0.07 3.72E-03 Nme3 NM_053507 -0.17 7.74E-04 Nmnat1 NM_001037556 0.13 7.97E-03 Nmral1 ENSRNOT00000005109 -0.08 0.03 Nmt1 NM_148891 0.08 7.30E-05 Noc4l NM_001014129 0.08 1.53E-05 Nol4 700643635F6 -0.1 1.17E-03 Nol5 AF069782 -0.08 0.02 Nola1 NM_001024306 0.06 5.88E-04 Nola3 ENSRNOT00000006887 0.06 3.42E-04 Nolc1 M94288 0.1 5.06E-04 Nosip ENSRNOT00000027882 -0.08 1.92E-06 Nova1 ENSRNOT00000044527 -0.3 1.98E-08 Npap60 NM_012991 -0.11 0.01 Npas2 ENSRNOT00000059571 -0.11 5.47E-03 Npc2 NM_173118 0.05 0.05 Nphp1 ENSRNOT00000021328 0.12 1.62E-06 Nphp4 ENSRNOT00000016271 -0.1 0.03 Npm3 ENSRNOT00000023963 0.16 2.34E-03 Nppc NM_053750 -0.14 0.04 Nptn NM_019380 0.08 5.28E-04 Nr1d2 NM_147210 -0.17 0.02 Nr2f6 NM_139113 -0.08 2.44E-03 Nr4a1 NM_024388 0.25 7.04E-05 Nr4a2 ENSRNOT00000041394 0.09 5.27E-03 Nrcam DV722487 0.19 2.99E-04 Nrd1 NM_012993 0.08 1.04E-03 Nrep AY724475 -0.51 2.95E-18 Nrip3 ENSRNOT00000017976 0.13 2.57E-05 Nrxn2 g8487405 0.08 9.13E-03 Nsdhl NM_001009399 0.1 2.16E-04 Nsf NM_021748 0.13 0.03 Nsmce1 NM_001039611 0.06 4.04E-03 Page 237 of 288 Diabetes

Nsmce2 NM_001024876 0.06 5.21E-03 Nt5c3 ENSRNOT00000007995 0.16 7.62E-09 Nt5c3l NM_001007723 0.07 0.02 Nt5dc2 NM_001009271 -0.07 0.02 Ntn1 BF287838 -0.07 0.02 Ntrk2 M55292 0.26 4.97E-09 Nub1 NM_001013925 -0.06 0.02 Nubp1 NM_001009619 -0.04 0.04 Nubp2 NM_001011891 0.07 7.08E-03 Nucks1 NM_022799 0.07 1.02E-03 Nudt19 NM_001004258 0.08 2.58E-03 Nudt4 NM_053598 -0.33 3.03E-19 Nudt5 NM_001007733 0.07 1.26E-03 Nufip1 NM_001007758 0.06 0.02 Numb NM_133287 0.05 0.05 Nup210 NM_053322 0.09 3.79E-03 Nup35 NM_001004229 0.08 3.10E-03 Nup54 NM_017361 -0.2 2.94E-07 Nup93 NM_001011925 0.06 8.53E-03 Nupl1 ENSRNOT00000017204 -0.12 2.55E-08 Nupr1 NM_053611 -0.35 1.79E-14 Nus1 g3706873 0.18 2.17E-12 Nvl ENSRNOT00000004927 0.1 6.71E-03 Nxt2 ENSRNOT00000025912 0.15 0.02 Oat NM_022521 0.15 5.73E-09 Obsl1 ENSRNOT00000020673 -0.28 1.34E-08 Ocrl ENSRNOT00000005267 -0.1 2.91E-06 Odf2 NM_017213 0.08 7.11E-03 Odz2 AF086608 -0.08 0.03 Ogdh ENSRNOT00000008375 -0.12 0.01 Ogdhl ENSRNOT00000027054 -0.11 8.61E-04 Ogfod1 DN934519 0.09 2.43E-04 Ogfod2 ENSRNOT00000001433 0.2 2.58E-03 Ogfrl1 NM_001025708 0.16 6.67E-09 Ogg1 NM_030870 0.07 0.02 Ola1 NM_001033927 0.09 1.36E-05 Olfm1 NM_053573 -0.24 6.47E-08 Olfm2 NM_001015017 -0.12 0.03 Olfm3 NM_145777 0.08 0.02 Olr1064 NM_001001076 0.13 0.01 Olr127 NM_001001026 -0.09 0.02 Olr1280 NM_001000517 -0.07 0.03 Olr1638 NM_001000834 0.12 0.04 Olr1666 NM_001000108 0.1 0.03 Olr203 NM_001000191 0.07 0.04 Olr218 NM_001000551 -0.12 0.03 Olr288 NM_001000231 -0.09 0.02 Diabetes Page 238 of 288

Olr424 NM_001000392 -0.11 0.02 Olr59 g4280953 -0.1 0.05 Oma1 ENSRNOT00000009516 0.07 4.98E-03 Opcml M88709 0.21 5.44E-05 Ophn1 ENSRNOT00000034772 -0.11 0.03 Oplah BF283094 0.14 1.06E-04 Opn1mw NM_053548 -0.08 0.05 Opn3 ENSRNOT00000005072 0.21 4.33E-04 Oprs1 NM_030996 0.1 1.96E-05 Orai2 ENSRNOT00000001938 -0.08 0.05 Orai3 NM_001014024 -0.06 0.03 Orc2l NM_001012003 0.07 1.67E-03 Orc5l NM_001014186 -0.09 0.02 Orc6l NM_001033690 0.08 2.98E-04 Ormdl2 ENSRNOT00000044292 0.19 7.57E-10 Osbpl5 ENSRNOT00000040748 0.1 4.53E-04 Osbpl9 ENSRNOT00000045953 0.05 9.41E-03 Osgepl1 BF415802 0.06 0.05 Ostf1 NM_148892 0.11 3.83E-04 Ostm1 NM_001029925 0.18 1.10E-09 Otor ENSRNOT00000034252 -0.09 0.04 Otub2 ENSRNOT00000012124 -0.06 0.02 Otud6b ENSRNOT00000008725 0.18 5.90E-03 Otud7b DV722502 -0.17 2.68E-04 Oxnad1 ENSRNOT00000026751 0.11 1.36E-04 Oxr1 ENSRNOT00000010754 0.09 0.05 Oxsr1 ENSRNOT00000018056 0.07 0.02 Oxt NM_012996 -0.09 0.02 P2ry1 NM_012800 0.3 9.49E-26 P4ha1 NM_172062 -0.14 2.27E-03 Pabpnl1 ENSRNOT00000045052 -0.19 3.87E-03 Pacsin1 XM_001078122 -0.1 0.05 Pafah1b1 NM_031763 -0.18 9.28E-07 Pafah1b2 703860644J1 0.06 0.04 Paip2 NM_001014148 -0.28 1.99E-23 Pak1 NM_017198 -0.05 0.04 Pak1ip1 NM_001037356 0.11 3.27E-07 Pak2 AA874829 0.08 0.01 Panx1 NM_199397 0.13 0.02 Papd4 NM_001008372 -0.17 8.32E-09 Papd5 ENSRNOT00000033307 -0.25 8.16E-10 Papola BC083612 -0.31 4.25E-11 Pappa ENSRNOT00000040898 0.1 0.03 Paqr3 NM_001012033 -0.28 1.51E-12 Paqr6 ENSRNOT00000036143 0.07 0.02 Pard3 BE110889 0.2 2.58E-04 Pard6b 704153559J1 0.05 0.05 Page 239 of 288 Diabetes

Parp1 BF393871 0.12 1.03E-03 Parp12 ENSRNOT00000011481 0.1 2.31E-06 Pask NM_001009362 -0.12 0.04 Pawr NM_033485 0.11 5.44E-04 Pbx3 ENSRNOT00000029600 0.11 0.04 Pcca M22631 0.15 3.58E-05 Pcdh10 XM_001054521 0.08 0.01 Pcdh19 ENSRNOT00000042335 0.13 0.01 Pcdh24 ENSRNOT00000024151 0.09 0.01 Pcdh9 AW529464 0.25 7.44E-03 Pcdhb14 ENSRNOT00000027168 0.13 6.63E-03 Pcdhb2 ENSRNOT00000060497 0.14 2.67E-05 Pcdhb5 ENSRNOT00000027206 0.09 0.02 Pcgf1 NM_001007000 0.07 0.02 Pcgf3 CA506321 -0.18 5.15E-04 Pcgf6 NM_001013154 -0.32 6.10E-18 Pck2 CB326419 -0.08 0.04 Pcmtd2 ENSRNOT00000023989 -0.05 0.02 Pcna NM_022381 -0.06 5.67E-04 Pcnx ENSRNOT00000010022 -0.07 8.05E-03 Pcsk5 U47014 0.07 0.04 Pcsk6 D31854 -0.22 1.07E-06 Pctp NM_017225 0.22 2.23E-15 Pcx NM_012744 0.08 7.06E-03 Pcyox1 AF332142 0.1 1.02E-04 Pcyt1a ENSRNOT00000002403 0.1 3.21E-04 Pdcd2 M80601 0.12 4.24E-06 Pdcd4 NM_022265 -0.12 2.05E-04 Pdcd5 ENSRNOT00000017708 0.05 5.95E-03 Pdcd6ip NM_001029910 0.1 5.73E-03 Pdcl NM_022247 -0.09 5.36E-03 Pdcl3 BI289420 -0.29 3.89E-17 Pde1c NM_031078 0.07 0.05 Pde2a NM_031079 -0.17 6.08E-03 Pde3b 703206608J1 -0.22 7.86E-10 Pde4a g4296767 0.14 8.45E-06 Pde6d ENSRNOT00000025262 0.05 0.05 Pde7a ENSRNOT00000043859 -0.18 1.26E-06 Pdhb NM_001007620 -0.2 2.31E-12 Pdhx NM_001044242 0.19 1.97E-16 Pdia2 ENSRNOT00000027726 -0.18 3.00E-07 Pdia3 NM_017319 -0.09 0.05 Pdk2 NM_030872 -0.16 2.28E-03 Pdk3 ENSRNOT00000017370 0.14 4.67E-05 Pdlim1 NM_017365 0.16 9.78E-07 Pdlim2 NM_001007622 0.09 0.03 Pdp2 NM_145091 -0.2 7.47E-03 Diabetes Page 240 of 288

Pdpk1 NM_031081 0.07 8.20E-03 Pdrg1 NM_001014762 0.12 2.52E-04 Pdxdc1 BQ781011 0.08 5.32E-03 Pdzd11 ENSRNOT00000003872 0.12 1.75E-03 Pdzk1ip1 NM_130401 -0.26 2.10E-06 Pea15a BG673078 -0.1 1.57E-03 Pebp1 NM_017236 0.03 0.05 Peci NM_001006966 0.08 5.82E-04 Peli2 CB776569 -0.23 1.42E-04 Pelo NM_001007634 0.1 1.97E-06 Pepd NM_001009641 0.15 2.71E-06 Per2 NM_031678 0.12 5.67E-04 Perp CK358419 0.1 3.53E-03 Pex1 BI296060 -0.1 1.51E-03 Pex11a NM_053487 -0.08 0.04 Pex26 XM_232260 -0.12 0.02 Pex7 NM_001034147 -0.21 2.00E-31 Pfas ENSRNOT00000007087 -0.05 0.05 Pfkfb1 NM_012621 0.12 0.03 Pfkfb2 NM_001033965 -0.11 3.22E-05 Pfkfb3 NM_057135 -0.37 7.13E-09 Pfkp NM_206847 0.08 2.52E-04 Pfn2 NM_030873 -0.19 1.18E-16 Pgam1 NM_053290 0.04 0.04 Pgap1 NM_201990 0.1 9.12E-03 Pgcp NM_031640 0.08 0.01 Pgk1 NM_053291 0.05 2.70E-03 Pgls ENSRNOT00000024827 -0.09 9.42E-03 Pgm1 NM_017033 0.07 8.72E-03 Pgm2 XM_214047 0.07 6.61E-03 Pgm2l1 ENSRNOT00000022963 -0.31 2.85E-10 Pgrmc2 AI137488 0.09 0.02 Ph-4 ENSRNOT00000027466 0.16 0.01 Phb NM_031851 0.16 1.65E-08 Phb2 NM_001013035 0.06 1.21E-04 Phc1 ENSRNOT00000020529 -0.18 8.31E-04 Phca ENSRNOT00000019987 0.14 2.00E-03 Phf10 NM_001024747 -0.14 2.10E-06 Phf12 ENSRNOT00000056234 -0.13 0.03 Phf13 ENSRNOT00000012407 -0.13 2.45E-03 Phf14 BF522926 -0.04 0.03 Phf20l1 ENSRNOT00000007564 -0.16 1.93E-03 Phf5a NM_138888 0.04 0.05 Phkg1 NM_031573 -0.17 3.17E-06 Phyhipl NM_001012076 -0.09 0.03 Pi4k2b NM_001005883 -0.19 1.21E-03 Pias2 NM_053337 -0.1 3.10E-06 Page 241 of 288 Diabetes

Pias4 CB323457 0.11 0.02 Pib5pa NM_133562 0.08 0.01 Picalm AY724477 0.1 7.75E-06 Pigc NM_001012207 -0.04 0.03 Pigh ENSRNOT00000014775 0.13 1.33E-04 Pigk NM_001011953 0.12 1.80E-07 Pigo ENSRNOT00000013213 -0.05 0.02 Pigq NM_001007607 -0.13 1.62E-05 Pigs NM_001006602 0.17 9.72E-10 Pigt ENSRNOT00000019761 0.1 1.45E-03 Pigv NM_001010966 0.12 8.11E-03 Pigw NM_194461 0.21 2.14E-13 Pigy NM_001024370 -0.07 1.29E-04 Pik3ap1 BC107660 0.18 7.44E-03 Pik3cb NM_053481 0.08 0.04 Pik3ip1 NM_001017453 -0.22 0.02 Pim1 NM_017034 -0.21 4.66E-03 Pin1 ENSRNOT00000027818 0.09 2.43E-03 Pink1 ENSRNOT00000020820 -0.09 9.85E-04 Pinx1 NM_001083337 0.08 5.99E-03 Pip4k2a AB032899 0.21 4.50E-06 Pip5k1c 703833217J1 -0.1 1.33E-03 Pitpna NM_017231 0.14 2.70E-05 Pitpnc1 ENSRNOT00000055097 0.15 0.01 Pja2 NM_138896 -0.09 1.54E-04 Pkd2 ENSRNOT00000002916 0.12 7.63E-05 Pklr NM_012624 -0.16 3.52E-06 Pkmyt1 ENSRNOT00000004936 -0.07 0.04 Pkn3 S68987 0.06 1.50E-03 Pknox1 NM_001013074 -0.1 6.09E-03 Pkp2 ENSRNOT00000002498 0.16 5.09E-08 Pla2g12a BI289553 0.15 7.77E-04 Pla2g6 NM_001005560 -0.37 3.67E-16 Plac8 ENSRNOT00000003012 0.06 0.05 Plagl1 NM_012760 -0.31 0.02 Plcb4 ENSRNOT00000049855 -0.14 0.02 Plcl1 NM_053456 -0.16 3.27E-05 Plcl2 ENSRNOT00000018146 0.08 0.01 Plekha6 XM_341118 -0.11 3.58E-03 Plekha8 ENSRNOT00000013528 0.12 3.25E-06 Plekhb1 NM_172033 -0.16 7.79E-10 Plekhf2 AI171635 0.26 0.01 Plekhg4 ENSRNOT00000022439 -0.09 0.03 Plekho1 DV718894 -0.08 3.71E-03 NM_017100 0.05 0.02 Plod1 NM_053827 0.09 4.13E-03 Plrg1 NM_021757 0.07 4.12E-03 Diabetes Page 242 of 288

Plscr1 NM_057194 0.13 0.03 Plxnb2 AY724531 -0.08 0.01 Plxnd1 ENSRNOT00000032158 -0.2 0.02 Pmm2 ENSRNOT00000003542 0.15 1.78E-09 Pmpca NM_001003673 0.09 7.19E-05 Pnck NM_017275 -0.15 5.81E-19 Pnkp NM_001004259 0.12 0.04 Pnma1 NM_130820 0.11 8.58E-03 Pnmal1 ENSRNOT00000029825 0.18 7.99E-05 Pnn ENSRNOT00000005439 -0.06 0.02 Pnpla8 704297787J1 -0.15 7.83E-04 Pnrc1 NM_173322 -0.25 5.11E-06 Pofut2 ENSRNOT00000001644 0.1 0.01 Polb NM_017141 0.13 4.60E-13 Pold2 NM_001013050 0.07 0.04 Pold3 NM_001024750 -0.14 1.61E-08 Pole2 ENSRNOT00000005835 -0.06 7.94E-03 Pole3 BC081988 -0.9 0 Pole4 XM_001071977 0.14 1.00E-08 Polh ENSRNOT00000026049 -0.07 0.04 Polm NM_001011912 -0.06 2.44E-03 Polr1e ENSRNOT00000029704 0.14 2.81E-07 Polr2c NM_001012473 0.06 0.02 Polr2f NM_031335 0.05 0.03 Polr2g NM_053948 -0.16 2.20E-23 Polr2i ENSRNOT00000028222 0.05 0.03 Polr2j ENSRNOT00000001941 -0.33 7.37E-21 Polr3a BC086344 0.11 6.73E-06 Polr3c NM_001012081 0.08 0.02 Polr3d NM_001031653 0.13 8.23E-09 Polr3e ENSRNOT00000040963 0.05 0.02 Polr3f ENSRNOT00000010468 0.08 0.02 Polr3g ENSRNOT00000061963 0.15 1.84E-03 Polr3h ENSRNOT00000005943 0.15 2.93E-11 Pols ENSRNOT00000023712 -0.13 2.56E-03 Pom121 NM_053622 -0.13 0.03 Pomc NM_139326 0.14 1.70E-08 Pomgnt1 NM_001007747 0.09 2.55E-03 Pomp NM_001100942 0.05 0.03 Pomt2 NM_001037097 0.08 5.06E-03 Pop5 ENSRNOT00000001591 0.1 1.54E-03 Popdc2 NM_199113 0.1 0.03 Por AI407454 0.07 5.32E-03 Porcn ENSRNOT00000045454 -0.08 6.58E-03 Postn ENSRNOT00000043665 -0.22 1.35E-04 Pp3111 NM_172018 0.08 1.28E-03 Ppa1 ENSRNOT00000000674 0.08 1.07E-04 Page 243 of 288 Diabetes

Ppapdc1b ENSRNOT00000058498 0.11 8.76E-05 Ppard 702426875T1 -0.05 0.04 Ppat ENSRNOT00000002905 0.06 0.05 Ppfia1 ENSRNOT00000039677 0.05 0.05 Ppfibp1 ENSRNOT00000044147 -0.2 3.40E-08 Pphln1 AY724510 0.12 6.02E-06 Ppib NM_022536 0.04 0.04 Ppif NM_172243 0.29 2.72E-28 Ppig CF112143 0.08 8.65E-04 Ppil3 NM_175707 0.15 4.59E-07 Ppil4 ENSRNOT00000021437 0.09 8.94E-03 Ppm1e NM_198773 0.15 1.94E-03 Ppm1f NM_175755 0.14 0.02 Ppm1g NM_147209 -0.1 0.02 Ppm1h NM_001013173 0.15 9.84E-03 Ppm1k DY471972 -0.09 0.05 Ppox ENSRNOT00000004896 -0.09 2.28E-03 Ppp1ca NM_031527 0.05 3.53E-03 Ppp1cc EV771210 -0.06 0.04 Ppp1r12a BQ782348 0.07 0.03 Ppp1r14a NM_130403 -0.23 4.76E-07 Ppp1r14b NM_172045 -0.5 0 Ppp1r14c NM_133425 0.2 1.07E-18 Ppp1r1b NM_138521 -0.13 1.56E-03 Ppp1r1c 702966828H1 -0.25 3.59E-03 Ppp1r3b NM_138912 -0.27 2.32E-06 Ppp1r3c NM_001012072 -0.29 0.02 Ppp1r3d 700371222F6 -0.2 2.09E-15 Ppp1r7 g4252073 -0.2 0.01 Ppp2r1a NM_057140 -0.18 1.51E-08 Ppp2r1b NM_001025418 0.07 3.70E-03 Ppp2r2b NM_022209 0.29 5.29E-06 Ppp2r2d NM_144746 0.07 0.02 Ppp2r3c NM_001014196 0.08 0.01 Ppp2r5a ENSRNOT00000000078 -0.05 0.01 Ppp2r5c XM_001077680 -0.18 2.13E-11 Ppp2r5d ENSRNOT00000022862 0.1 1.03E-03 Ppp3cc NM_134367 0.16 1.32E-09 Ppp3r1 NM_017309 0.17 7.14E-13 Ppp4r1 NM_080907 -0.19 5.76E-04 Ppp4r2 ENSRNOT00000029115 -0.14 3.02E-03 Ppp6c NM_133589 0.12 5.12E-07 Ppt1 ENSRNOT00000017998 -0.16 1.57E-08 Ppt2 NM_019367 0.17 2.99E-07 Pqlc1 NM_001013189 0.13 1.82E-04 Pqlc2 ENSRNOT00000023896 0.19 5.84E-11 Pqlc3 NM_001034952 0.08 0.03 Diabetes Page 244 of 288

Praf2 XM_001058767 0.18 3.46E-14 Prdm10 XM_001056255 -0.08 0.02 Prdm4 NM_133312 0.06 2.45E-03 Prdx3 NM_022540 0.07 5.81E-04 Prdx6 NM_053576 0.06 0.03 Prep NM_031324 0.07 3.83E-03 Prg-3 NM_201271 0.15 2.13E-04 Prickle4 ENSRNOT00000018959 0.07 1.96E-03 Prkaa1 BM392332 -0.19 5.00E-10 Prkaa2 NM_023991 -0.56 3.64E-10 Prkab1 NM_031976 -0.06 0.04 Prkaca ENSRNOT00000007303 -0.33 1.49E-04 Prkacb ENSRNOT00000045967 -0.04 0.03 Prkag1 NM_013010 -0.09 2.98E-05 Prkar1a CF110967 -0.27 5.65E-25 Prkar2a g18186932 0.26 7.29E-16 Prkcb1 AI709696 0.13 9.88E-04 Prkci ENSRNOT00000012924 0.13 5.11E-03 Prkd3 ENSRNOT00000007492 -0.39 3.49E-05 Prlr S82907 0.25 1.64E-03 Prmt2 NM_001025144 -0.11 1.21E-05 Prmt5 XM_001054376 0.09 8.40E-04 Prnp NM_012631 -0.09 1.07E-03 Prnpip1 BC099220 0.06 0.01 Prok2 NM_138852 -0.46 1.84E-05 Prpf31 ENSRNOT00000018683 0.09 1.64E-04 Prpf38a ENSRNOT00000012635 0.08 0.03 Prpf4 ENSRNOT00000019910 0.04 0.02 Prpf40a ENSRNOT00000006549 0.1 0.03 Prps1 NM_017243 -0.2 3.02E-13 Prps2 NM_012634 -0.15 9.86E-06 Prr13 NM_001008379 -0.05 0.01 Prrc1 NM_001033887 0.19 1.87E-13 Prss23 NM_001007691 0.24 9.57E-06 Prtfdc1 ENSRNOT00000034907 -0.27 5.59E-11 Prune NM_001007697 -0.08 1.56E-03 Psat1 NM_198738 -0.28 2.14E-23 Pscd1 NM_053910 -0.31 3.40E-10 Pscd3 NM_053912 0.1 0.02 Psenen NM_001008764 -0.06 2.61E-03 Psip1 BC093606 -0.18 1.38E-07 Pskh1 ENSRNOT00000026163 0.08 0.03 Psma1 NM_017278 -0.07 0.02 Psma3 NM_017280 0.15 1.15E-07 Psma4 NM_017281 0.11 2.80E-05 Psma5 NM_017282 0.05 0.02 Psma6 NM_017283 0.06 0.01 Page 245 of 288 Diabetes

Psma7 NM_001008217 0.07 3.88E-04 Psmb3 NM_017285 0.06 0.01 Psmb4 NM_031629 -0.15 4.05E-06 Psmb6 NM_057099 0.07 2.09E-03 Psmc1 NM_057123 0.07 4.61E-03 Psmc3 NM_031595 0.1 6.68E-06 Psmc3ip NM_134458 0.07 6.58E-03 Psmc5 NM_031149 0.07 7.07E-03 Psmc6 ENSRNOT00000009649 0.11 8.98E-04 Psmd1 BC087654 -0.14 8.05E-04 Psmd10 NM_053925 0.09 0.04 Psmd12 NM_001005875 -0.16 4.20E-08 Psmd9 CN544277 0.11 0.02 Psme3 NM_001011894 0.16 3.72E-14 Psmg2 ENSRNOT00000024126 -0.04 7.25E-03 Psph NM_001009679 -0.09 0.02 Ptbp2 NM_001005555 -0.21 3.77E-08 Ptcd2 ENSRNOT00000034992 0.06 0.04 Ptdss2 ENSRNOT00000021925 0.08 2.78E-03 Ptges2 ENSRNOT00000019184 -0.12 1.50E-03 Ptgfrn NM_019243 0.1 0.01 Ptgs1 NM_017043 -0.11 0.01 Pthlh NM_012636 0.13 9.47E-05 Pthr1 NM_020073 -0.17 1.40E-04 Ptk2b NM_017318 0.07 5.53E-04 Ptn BG664127 -0.1 0.02 Ptp4a1 ENSRNOT00000016237 0.12 5.20E-09 Ptpla NM_001101001 0.15 3.73E-07 Ptpmt1 ENSRNOT00000013584 0.12 4.77E-07 Ptpn18 NM_001013111 0.06 0.04 Ptpn21 NM_133545 0.13 0.03 Ptpn6 NM_053908 0.12 2.97E-05 Ptpn9 NM_001013040 0.08 5.43E-04 Ptpra NM_012763 0.05 0.02 Ptprb ENSRNOT00000006501 -0.08 0.05 Ptprd L19181 -0.1 0.01 Ptpre ENSRNOT00000021359 -0.21 0.02 Pttg1ip NM_001013238 -0.04 0.05 Pum2 XM_001068003 -0.09 0.02 Purb NM_001017503 0.11 7.46E-04 Pus3 ENSRNOT00000017648 0.07 0.01 Pus7 ENSRNOT00000014063 0.11 2.79E-03 Pusl1 BC091248 0.09 0.04 PVR NM_017076 0.26 4.02E-21 Pvrl2 NM_001012064 -0.09 7.42E-03 Pxmp4 NM_172223 0.14 1.43E-04 Pxn NM_001012147 -0.19 5.33E-03 Diabetes Page 246 of 288

Pycard NM_172322 0.08 0.02 Pycr1 ENSRNOT00000054949 0.08 0.05 Pycr2 NM_001012208 0.11 1.17E-07 Pygm AI717476 -0.13 0.04 Pygo1 ENSRNOT00000037686 0.13 0.01 Pyroxd1 NM_001004234 0.09 2.99E-05 Qdpr NM_022390 0.13 3.52E-04 Qki DN933927 0.16 3.18E-03 Qrsl1 BF550674 -0.09 2.39E-04 Qsox1 AF217799 0.1 1.94E-03 R3hcc1_predicted ENSRNOT00000022706 0.13 8.30E-04 R3hdm1 ENSRNOT00000005372 0.07 0.02 Rab10 NM_017359 0.05 0.02 Rab11a NM_031152 -0.19 2.55E-22 Rab11fip4 704233939H1 -0.16 3.19E-04 Rab13 NM_031092 0.11 1.98E-03 Rab18 NM_001012468 -0.07 0.04 Rab24 NM_001015023 0.1 3.04E-03 Rab27a NM_017317 0.14 9.63E-03 Rab28 NM_053978 0.08 1.68E-03 Rab33a ENSRNOT00000008868 -0.12 4.54E-04 Rab33b DV725908 -0.33 5.66E-12 Rab34 NM_001012140 -0.07 0.04 Rab36 ENSRNOT00000001772 -0.13 4.11E-05 Rab39 ENSRNOT00000011913 0.14 1.22E-05 Rab3c NM_133536 0.11 1.66E-06 Rab40c NM_182675 0.16 5.34E-03 Rab4b NM_017355 0.09 5.24E-05 Rab7l1 NM_133590 0.06 0.05 Rab8a NM_053998 0.07 0.02 Rabac1 NM_031774 -0.2 9.49E-09 Rabep1 NM_019124 0.09 3.65E-04 Rabepk NM_001024871 0.13 4.26E-06 Rabgap1 ENSRNOT00000013378 -0.14 6.61E-05 Rabggta NM_031654 -0.1 1.19E-04 Rabl2a NM_001013221 -0.32 5.07E-07 Rabl4 ENSRNOT00000008450 0.11 7.76E-06 Rabl5 NM_001011902 0.09 2.80E-03 Racgap1 ENSRNOT00000024796 -0.09 2.24E-03 Rad51c ENSRNOT00000008846 -0.13 0.01 Rad51l3 ENSRNOT00000038376 0.08 1.46E-03 Rad9b NM_001030042 -0.13 0.04 Rai1 AY724505 -0.12 0.03 Rai12 NM_001001718 0.06 8.18E-04 Rai14 NM_001011947 0.14 1.29E-03 Rai2 ENSRNOT00000008703 0.14 0.05 Rala NM_031093 0.09 1.46E-03 Page 247 of 288 Diabetes

Ralb NM_053821 0.11 8.24E-05 Ralbp1 NM_032067 -0.08 0.04 Ralgps2 ENSRNOT00000006511 0.12 4.00E-04 Raly NM_001011958 -0.12 8.38E-04 Ramp2 NM_031646 0.16 2.15E-03 Rangrf ENSRNOT00000006883 0.08 7.94E-03 Rap1a NM_001005765 -0.25 7.91E-17 Rap1b BC081731 -0.26 5.60E-11 Rap2a BQ208481 0.14 6.14E-06 Rapgef2 ENSRNOT00000029340 0.11 1.49E-05 Rapgef4 ENSRNOT00000048797 -0.22 1.74E-09 Rars2 ENSRNOT00000011688 0.12 1.80E-06 Rasa1 CF249348 -0.29 1.60E-21 Rasa3 AI237779 -0.16 2.70E-03 Rasgef1c ENSRNOT00000059277 -0.19 0.03 Rassf3 AA893698 -0.22 4.02E-15 Rassf7 ENSRNOT00000023219 -0.06 0.02 Raver2 XM_001061591 0.12 1.87E-03 Rb1 ENSRNOT00000021752 -0.12 2.41E-04 Rb1cc1 ENSRNOT00000010014 -0.16 2.16E-04 Rbbp5 ENSRNOT00000036110 0.09 0.01 Rbbp6 701864133T1 0.1 8.77E-03 Rbl1 ENSRNOT00000009528 -0.09 0.02 Rbm12 NM_001037657 0.06 0.02 Rbm13 NM_001014002 0.07 0.02 Rbm17 NM_001013058 0.07 2.58E-03 Rbm18 XM_001080367 -0.22 2.78E-22 Rbm28 ENSRNOT00000007777 0.09 1.00E-03 Rbm3 ENSRNOT00000007367 0.09 7.81E-03 Rbm34 NM_001014015 0.11 9.32E-04 Rbm41 702966479F6 -0.17 4.35E-05 Rbm4b ENSRNOT00000026611 0.07 4.96E-03 Rbm7 ENSRNOT00000007736 0.1 8.33E-04 Rbm9 ENSRNOT00000056270 0.05 0.04 Rbmxrtl ENSRNOT00000016184 -0.08 0.01 Rc3h2 ENSRNOT00000012354 -0.09 0.02 Rcan2 NM_175578 0.2 7.97E-07 Rcc2 ENSRNOT00000008940 -0.2 6.65E-05 rCG_22919 DV716116 -0.37 5.45E-19 rCG_28701 ENSRNOT00000019647 0.09 4.37E-04 rCG_48149 ENSRNOT00000027486 0.12 2.80E-03 Rcn2 NM_017132 0.13 9.04E-13 Rdh11 NM_001012193 0.11 3.93E-04 Rdh14 NM_001011982 -0.08 0.04 Rdh2 NM_199208 -0.1 0.05 Rdm1 XM_001081488 -0.12 6.38E-03 Rdx BF557204 -0.22 3.12E-10 Diabetes Page 248 of 288

Reck ENSRNOT00000020755 0.41 3.48E-32 Reep1 CK840780 0.21 0.03 Reep3 ENSRNOT00000000801 -0.29 3.87E-03 Reep4 NM_001025279 0.14 3.10E-04 Reep5 BI274372 0.08 0.03 Rell1 ENSRNOT00000002984 -0.15 4.58E-04 Reln BF387628 0.07 0.05 Relt ENSRNOT00000038408 0.08 0.04 Rem2 NM_022685 -0.13 3.27E-04 Reps2 ENSRNOT00000058993 -0.16 4.76E-03 Ret NM_012643 -0.22 0.05 Rfc2 NM_053786 0.06 1.56E-03 Rft1 ENSRNOT00000035542 0.07 0.03 Rfx1 ENSRNOT00000008104 -0.13 0.02 Rfx5 BC089912 -0.2 9.98E-14 Rfxank NM_001013136 0.06 7.45E-03 Rfxdc2 ENSRNOT00000030629 -0.2 5.85E-04 RGD1302996 NM_213610 -0.13 0.02 RGD1303003 NM_001004225 0.06 2.22E-03 RGD1303142 NM_201560 -0.07 0.01 RGD1304607 ENSRNOT00000028079 0.15 3.83E-07 RGD1304621 XM_001073237 0.11 8.87E-03 RGD1304624 ENSRNOT00000009180 0.08 0.01 RGD1304704 NM_001047874 0.08 4.13E-05 RGD1304719 NM_001037769 -0.11 6.51E-10 RGD1304748 NM_001025634 0.08 4.77E-03 RGD1304773 NM_001025126 0.1 2.69E-03 RGD1304792 ENSRNOT00000009104 0.08 0.03 RGD1304825 ENSRNOT00000022014 0.1 0.05 RGD1304827 NM_001009437 -0.09 8.71E-03 RGD1304924 ENSRNOT00000030458 0.09 0.02 RGD1304982 ENSRNOT00000006924 0.06 7.34E-03 RGD1305014 NM_001014025 0.11 1.24E-06 RGD1305038 ENSRNOT00000042204 -0.26 7.31E-05 RGD1305045 ENSRNOT00000008364 0.12 3.50E-07 RGD1305138 XM_235689 0.14 1.66E-03 RGD1305222 XM_001073162 0.11 9.59E-08 RGD1305235 NM_001017447 -0.2 7.96E-11 RGD1305274 ENSRNOT00000014401 0.1 0.01 RGD1305288 NM_001013995 -0.09 0.02 RGD1305344 ENSRNOT00000024150 -0.1 0.03 RGD1305350 ENSRNOT00000010558 -0.1 6.60E-04 RGD1305457 ENSRNOT00000010929 0.15 4.05E-04 RGD1305592 NM_001013901 -0.09 3.31E-03 RGD1305613 NM_001039208 0.1 2.86E-03 RGD1305645 XM_343562 0.19 2.01E-06 RGD1305727 NM_001047095 0.09 3.52E-04 Page 249 of 288 Diabetes

RGD1305754 ENSRNOT00000012606 0.1 1.55E-03 RGD1306063 CV796320 0.12 6.25E-03 RGD1306151 ENSRNOT00000011241 -0.21 9.12E-08 RGD1306215 ENSRNOT00000020806 -0.14 4.98E-07 RGD1306227 NM_001014037 -0.07 0.03 RGD1306371 ENSRNOT00000006841 0.07 0.02 RGD1306404 ENSRNOT00000014082 0.13 0.01 RGD1306410 NM_001014126 0.05 0.01 RGD1306437 NM_001009635 0.08 1.27E-05 RGD1306474 ENSRNOT00000007610 -0.17 0.01 RGD1306500 XM_001081783 -0.1 0.02 RGD1306502 ENSRNOT00000039234 -0.17 3.03E-11 RGD1306565 XM_001073260 0.06 0.03 RGD1306568 NM_001013963 -0.2 4.60E-08 RGD1306582 BF387456 0.1 2.07E-04 RGD1306583 NM_001013908 0.08 4.54E-04 RGD1306595 NM_001025626 -0.1 1.50E-06 RGD1306596 NM_001029923 0.14 2.77E-04 RGD1306626 NM_001039612 0.19 1.90E-03 RGD1306703 ENSRNOT00000021756 0.09 0.01 RGD1306730 NM_001039608 0.04 0.01 RGD1306746 ENSRNOT00000023654 -0.1 7.04E-05 RGD1306772 NM_001044226 0.1 0.02 RGD1306809 NM_001044252 -0.15 4.03E-04 RGD1306839 ENSRNOT00000021544 0.13 3.86E-06 RGD1306862 ENSRNOT00000008107 0.09 9.80E-03 RGD1306880 ENSRNOT00000011586 0.08 0.04 RGD1306924 ENSRNOT00000018460 0.1 4.19E-05 RGD1306932 NM_001024996 0.06 0.02 RGD1306936 ENSRNOT00000011970 0.14 1.04E-14 RGD1306939 BC089211 -0.1 0.03 RGD1306962 ENSRNOT00000021944 0.1 0.01 RGD1307071 ENSRNOT00000036527 -0.09 0.04 RGD1307155 ENSRNOT00000037381 0.08 1.29E-04 RGD1307218 NM_001014190 -0.09 0.02 RGD1307234 ENSRNOT00000019206 -0.17 7.56E-08 RGD1307235 BE105873 -0.09 0.03 RGD1307254 NM_001024875 0.09 2.79E-04 RGD1307325 NM_001014001 -0.56 0 RGD1307365 ENSRNOT00000014165 -0.13 9.42E-05 RGD1307390 ENSRNOT00000018495 -0.31 1.19E-12 RGD1307392 ENSRNOT00000013560 0.05 0.02 RGD1307410 ENSRNOT00000038993 0.08 0.03 RGD1307465 NM_001009655 -0.19 7.01E-08 RGD1307493 ENSRNOT00000010168 0.15 6.21E-03 RGD1307509 NM_001014036 0.18 8.70E-06 RGD1307526 DY314397 -0.33 1.11E-08 Diabetes Page 250 of 288

RGD1307554 CO404930 -0.16 6.42E-07 RGD1307597 703902328J1 -0.08 9.92E-03 RGD1307648 NM_001013905 0.15 3.82E-07 RGD1307682 NM_001024760 -0.22 2.34E-06 RGD1307696 DW395452 -0.27 2.84E-07 RGD1307736 BI290140 0.21 8.16E-09 RGD1307752 NM_001013922 0.1 9.16E-08 RGD1307773 BQ210499 0.12 8.31E-06 RGD1307799 NM_001017454 0.06 1.07E-03 RGD1307830 ENSRNOT00000059984 0.07 0.04 RGD1307943 ENSRNOT00000014252 0.17 2.03E-05 RGD1307983 ENSRNOT00000022987 -0.14 1.49E-06 RGD1308023 ENSRNOT00000015414 -0.25 1.03E-08 RGD1308031 NM_001009667 0.07 6.58E-03 RGD1308059 NM_001025022 -0.07 0.03 RGD1308134 ENSRNOT00000025491 -0.06 3.03E-03 RGD1308147 NM_001014010 0.09 1.08E-05 RGD1308154 ENSRNOT00000002356 -0.16 0.01 RGD1308179 ENSRNOT00000005504 0.21 5.74E-06 RGD1308221 ENSRNOT00000004093 -0.2 2.00E-11 RGD1308251 ENSRNOT00000018453 0.14 5.17E-03 RGD1308290 NM_001047902 -0.1 0.02 RGD1308299 ENSRNOT00000016923 -0.1 0.02 RGD1308302 NM_001008346 0.12 4.34E-04 RGD1308432 CA509333 0.14 1.96E-07 RGD1308448 ENSRNOT00000019524 -0.26 6.94E-05 RGD1308470 NM_001014198 0.12 8.21E-06 RGD1308517 NM_001037181 -0.09 8.33E-03 RGD1308557 ENSRNOT00000012551 0.16 1.13E-04 RGD1308600 NM_001014178 0.11 4.97E-04 RGD1308601 CB775949 -0.28 4.89E-15 RGD1308635 ENSRNOT00000025386 0.15 6.84E-09 RGD1308706 ENSRNOT00000023169 -0.32 2.31E-12 RGD1308723 ENSRNOT00000041897 0.08 4.69E-03 RGD1308759 BE100383 -0.06 6.50E-03 RGD1308782 NM_001025677 0.1 6.70E-03 RGD1308813 NM_001013974 0.09 5.54E-03 RGD1308847 NM_001100945 0.19 8.06E-05 RGD1308874 NM_001034003 -0.06 0.04 RGD1308915 NM_001014226 0.15 3.06E-04 RGD1308917 ENSRNOT00000006321 0.07 0.04 RGD1308923 XM_001076736 -0.09 2.04E-06 RGD1308929 BM384224 0.12 0.02 RGD1309020 ENSRNOT00000018508 -0.1 0.01 RGD1309051 NM_001013944 0.1 1.32E-05 RGD1309077 ENSRNOT00000056278 0.12 3.73E-03 RGD1309079 NM_001047890 0.12 0.03 Page 251 of 288 Diabetes

RGD1309104 BE111666 -0.33 2.99E-25 RGD1309148 ENSRNOT00000031852 0.07 8.85E-03 RGD1309188 ENSRNOT00000012269 0.07 0.01 RGD1309216 NM_001008371 0.13 6.54E-06 RGD1309228 g14949127 0.13 4.39E-04 RGD1309387 NM_001033897 0.09 3.81E-03 RGD1309410 ENSRNOT00000014827 0.09 0.02 RGD1309437 NM_001013866 0.07 0.05 RGD1309482 NM_001014246 0.07 3.01E-03 RGD1309483 ENSRNOT00000036852 -0.13 0.02 RGD1309534 NM_001014206 -0.06 0.04 RGD1309605 ENSRNOT00000022986 0.12 9.05E-05 RGD1309676 NM_001014140 -0.21 4.12E-05 RGD1309710 ENSRNOT00000028695 -0.09 8.14E-05 RGD1309748 ENSRNOT00000003439 0.1 0.03 RGD1309759 ENSRNOT00000020810 0.11 9.61E-08 RGD1309779 ENSRNOT00000011017 -0.28 3.68E-21 RGD1309784 NM_001014212 -0.19 1.53E-08 RGD1309804 NM_001014167 0.11 1.80E-03 RGD1309839 ENSRNOT00000025140 0.13 7.57E-05 RGD1309871 XM_001076952 -0.33 3.33E-22 RGD1309873 ENSRNOT00000014007 -0.07 0.05 RGD1309879 NM_001011711 -0.14 1.81E-04 RGD1309979 BU759932 0.09 3.75E-04 RGD1309995 BC091295 -0.08 6.06E-03 RGD1310061 BQ201615 0.07 0.04 RGD1310159 XM_222190 -0.14 5.78E-05 RGD1310230 AI511030 0.09 0.02 RGD1310263 704197764H1 -0.2 3.24E-04 RGD1310270 ENSRNOT00000038144 -0.17 3.00E-09 RGD1310335 ENSRNOT00000033837 0.11 2.71E-04 RGD1310348 ENSRNOT00000046594 0.07 9.64E-03 RGD1310351 XM_216499 0.07 1.09E-03 RGD1310352 ENSRNOT00000008119 -0.16 1.44E-05 RGD1310358 CO402386 -0.19 1.09E-08 RGD1310423 NM_001029920 0.07 0.02 RGD1310427 ENSRNOT00000024450 -0.35 2.49E-24 RGD1310440 AA943016 -0.06 6.13E-04 RGD1310484 703830562J1 0.05 0.03 RGD1310571 AI599496 0.16 1.24E-04 RGD1310597 NM_001025647 0.05 0.02 RGD1310606 NM_001024984 0.14 8.38E-12 RGD1310660 NM_001009316 0.16 1.13E-08 RGD1310693 ENSRNOT00000026384 -0.11 0.03 RGD1310769 AI172515 0.16 2.44E-13 RGD1310784 ENSRNOT00000020637 0.08 2.89E-03 RGD1310861 NM_001008290 -0.1 1.74E-05 Diabetes Page 252 of 288

RGD1310862 ENSRNOT00000028186 -0.37 1.55E-04 RGD1310922 ENSRNOT00000027989 0.07 7.52E-03 RGD1310975 ENSRNOT00000017800 0.13 4.31E-07 RGD1310994 NM_001012470 -0.26 0.02 RGD1311021 XM_001065468 0.11 6.04E-03 RGD1311045 ENSRNOT00000005587 0.12 2.39E-03 RGD1311055 ENSRNOT00000023709 0.06 0.03 RGD1311066 ENSRNOT00000027369 0.06 0.05 RGD1311122 NM_001037792 -0.06 0.03 RGD1311164 ENSRNOT00000026838 0.06 0.03 RGD1311249 NM_001013931 0.1 2.51E-04 RGD1311257 NM_001008307 0.12 9.52E-07 RGD1311260 NM_001013967 0.15 9.25E-14 RGD1311324 NM_001014195 0.1 0.05 RGD1311358 NM_001017448 0.06 0.01 RGD1311364 NM_001008325 0.11 2.19E-07 RGD1311424 ENSRNOT00000034919 0.06 0.05 RGD1311429 XM_001081572 0.07 0.02 RGD1311435 ENSRNOT00000055607 0.09 2.88E-04 RGD1311458 NM_001009678 0.06 0.02 RGD1311517 NM_001014072 0.15 2.97E-04 RGD1311563 BI296244 -0.05 0.03 RGD1311564 ENSRNOT00000007379 -0.11 0.01 RGD1311578 BI275982 0.06 4.40E-03 RGD1311605 ENSRNOT00000008555 0.08 0.02 RGD1311612 ENSRNOT00000019993 0.1 8.34E-05 RGD1311648 NM_001014075 0.11 1.17E-04 RGD1311742 NM_001025636 0.13 1.54E-04 RGD1311745 NM_001008329 0.08 1.74E-06 RGD1311783 ENSRNOT00000027196 -0.19 5.84E-05 RGD1311805 NM_001009638 0.17 2.08E-06 RGD1311815 NM_001034149 0.26 2.76E-22 RGD1311863 NM_001024974 0.19 6.71E-10 RGD1311874 ENSRNOT00000012381 -0.2 3.36E-05 RGD1311910 ENSRNOT00000045873 0.1 0.02 RGD1311925 BC098826 -0.09 2.54E-05 RGD1311939 ENSRNOT00000005664 -0.12 0.01 RGD1311940 ENSRNOT00000013623 0.07 0.04 RGD1311946 NM_001025683 0.35 3.12E-09 RGD1311970 ENSRNOT00000034137 0.25 5.97E-10 RGD1359108 NM_001007702 -0.1 1.36E-05 RGD1359127 NM_001007657 0.16 1.17E-05 RGD1359191 NM_001007706 0.14 4.98E-06 RGD1359378 NM_001007658 -0.11 0.02 RGD1359380 NM_001007676 0.09 6.96E-04 RGD1359452 CK842976 0.08 0.03 RGD1359508 NM_001009707 0.11 2.67E-07 Page 253 of 288 Diabetes

RGD1359600 ENSRNOT00000022519 0.15 3.23E-07 RGD1359713 NM_001005882 0.16 3.34E-08 RGD1559566 ENSRNOT00000042622 0.11 4.07E-03 RGD1559610 ENSRNOT00000009882 0.07 3.01E-05 RGD1559690 ENSRNOT00000031974 -0.26 4.64E-14 RGD1559743 ENSRNOT00000049805 0.11 5.60E-04 RGD1559786 CB568086 0.07 0.04 RGD1559856 ENSRNOT00000028520 0.12 7.53E-03 RGD1559859 XM_347117 0.08 0.02 RGD1559896 ENSRNOT00000025512 -0.1 9.28E-05 RGD1559904 XM_232783 0.07 0.04 RGD1559909 CN544457 0.06 0.05 RGD1559923 ENSRNOT00000020074 -0.34 8.44E-19 RGD1559961 ENSRNOT00000003886 0.15 0.02 RGD1560010 ENSRNOT00000013356 -0.18 5.08E-07 RGD1560065 ENSRNOT00000019964 0.14 2.62E-09 RGD1560157 AI137641 0.1 3.97E-03 RGD1560212 NM_001077676 0.07 1.35E-03 RGD1560277 XM_001066043 0.1 7.99E-04 RGD1560359 XM_578801 0.09 0.02 RGD1560433 XM_001061644 0.11 0.01 RGD1560544_predicted ENSRNOT00000028495 -0.06 0.05 RGD1560555 XM_577908 0.11 0.02 RGD1560566 ENSRNOT00000027094 0.12 1.03E-03 RGD1560588 XM_577802 -0.06 0.02 RGD1560600 ENSRNOT00000008057 0.11 1.93E-04 RGD1560638 702967109H1 0.11 0.01 RGD1560652 ENSRNOT00000007422 0.11 1.55E-03 RGD1560658 ENSRNOT00000049507 0.12 8.63E-03 RGD1560687 ENSRNOT00000052297 0.17 4.18E-03 RGD1560755 703906845J1 0.06 7.35E-04 RGD1560888 XM_001061556 0.08 2.98E-03 RGD1560900 XM_001080998 0.08 0.03 RGD1560909 ENSRNOT00000031352 0.11 7.52E-03 RGD1560911_predicted ENSRNOT00000025964 -0.16 2.89E-04 RGD1561030 ENSRNOT00000005722 -0.25 1.11E-03 RGD1561042 ENSRNOT00000006968 -0.06 0.03 RGD1561067 XM_573923 -0.17 3.61E-09 RGD1561069 NM_001044259 0.12 9.55E-06 RGD1561090 XM_233065 0.17 2.09E-03 RGD1561102 XM_001080032 0.18 3.77E-04 RGD1561113 ENSRNOT00000034930 0.09 0.03 RGD1561141 XM_230015 -0.14 6.14E-08 RGD1561176 ENSRNOT00000012114 0.09 0.02 RGD1561195 ENSRNOT00000046725 0.07 0.03 RGD1561196_predicted ENSRNOT00000012842 0.1 8.99E-04 RGD1561205 ENSRNOT00000056229 0.07 0.04 Diabetes Page 254 of 288

RGD1561302 CK597015 -0.28 9.49E-11 RGD1561360 XM_220630 0.04 0.05 RGD1561444 ENSRNOT00000031893 0.1 4.93E-03 RGD1561459 ENSRNOT00000016783 0.14 0.01 RGD1561474 ENSRNOT00000058589 -0.17 0.01 RGD1561494 ENSRNOT00000013128 0.08 0.03 RGD1561605 ENSRNOT00000037061 -0.17 2.95E-04 RGD1561654 XM_001079552 -0.13 0.05 RGD1561676 ENSRNOT00000025424 0.06 6.78E-03 RGD1561708 BF404635 -0.2 7.28E-04 RGD1561732 ENSRNOT00000060286 -0.09 0.05 RGD1561796 XM_001077638 0.12 1.32E-03 RGD1561807 ENSRNOT00000045477 0.11 1.99E-06 RGD1561813 ENSRNOT00000037478 0.1 0.03 RGD1561932 ENSRNOT00000003841 0.12 8.88E-03 RGD1561963 ENSRNOT00000038528 0.19 9.60E-05 RGD1562020 XM_214370 -0.1 7.83E-03 RGD1562052 XM_573539 -0.2 2.67E-03 RGD1562071 XM_575276 0.07 0.03 RGD1562135 XM_575333 0.1 3.16E-04 RGD1562136 ENSRNOT00000045749 0.1 4.98E-03 RGD1562218 NM_001034919 -0.39 2.75E-19 RGD1562272 ENSRNOT00000000260 -0.15 5.76E-04 RGD1562339 CN541977 0.12 2.01E-04 RGD1562351 XM_001062525 0.11 3.16E-05 RGD1562381 ENSRNOT00000040565 0.06 0.01 RGD1562404 ENSRNOT00000051652 -0.05 0.04 RGD1562446 XM_001079744 -0.1 6.61E-03 RGD1562449 ENSRNOT00000013599 0.15 1.06E-03 RGD1562502 ENSRNOT00000003667 0.08 2.31E-03 RGD1562504 ENSRNOT00000041516 0.05 0.04 RGD1562526 ENSRNOT00000006504 0.19 1.05E-07 RGD1562529 AA946404 -0.17 8.45E-06 RGD1562545 XM_001061198 -0.05 0.01 RGD1562607 ENSRNOT00000005884 -0.12 0.04 RGD1562618 AW919316 0.11 0.05 RGD1562657 ENSRNOT00000036185 0.1 0.02 RGD1562665 XM_343264 0.13 5.22E-07 RGD1562691 ENSRNOT00000021637 0.15 2.80E-06 RGD1562767 ENSRNOT00000006092 0.11 7.92E-04 RGD1562965 AA851969 -0.15 0.02 RGD1562987 ENSRNOT00000025198 0.07 3.76E-04 RGD1563106 ENSRNOT00000007447 -0.14 8.41E-04 RGD1563216 XM_576075 0.18 2.26E-21 RGD1563226 ENSRNOT00000035153 0.14 2.21E-08 RGD1563235 EV765652 -0.12 1.85E-05 RGD1563319 ENSRNOT00000027344 0.31 0.01 Page 255 of 288 Diabetes

RGD1563351 XM_001079990 0.13 9.86E-03 RGD1563365 702992208T1 0.1 3.01E-03 RGD1563422 NM_001077643 0.09 1.34E-03 RGD1563438 ENSRNOT00000056870 0.16 7.51E-04 RGD1563441 ENSRNOT00000012061 -0.09 6.83E-03 RGD1563482 ENSRNOT00000001421 0.15 5.37E-06 RGD1563547 XM_346881 0.06 0.02 RGD1563612 ENSRNOT00000011395 -0.34 2.26E-16 RGD1563634 NM_001081447 0.09 1.51E-04 RGD1563839 XM_345435 0.13 4.22E-03 RGD1563853 ENSRNOT00000026653 -0.1 4.65E-04 RGD1563888 ENSRNOT00000002119 -0.14 0.02 RGD1563941 ENSRNOT00000007754 0.14 1.94E-08 RGD1563952 XM_001071071 0.19 1.90E-05 RGD1563973 ENSRNOT00000038055 0.11 3.84E-03 RGD1564174 XM_001054328 -0.07 0.03 RGD1564209 XM_001053896 -0.12 0.02 RGD1564247 XM_574899 0.09 9.25E-03 RGD1564268 ENSRNOT00000041359 0.05 0.03 RGD1564300 ENSRNOT00000027967 -0.1 1.04E-03 RGD1564324 XM_214176 -0.14 3.22E-03 RGD1564420 ENSRNOT00000013315 0.07 9.55E-03 RGD1564452 NM_001100136 0.11 3.18E-05 RGD1564454 XM_575014 -0.06 8.91E-03 RGD1564456 ENSRNOT00000048933 -0.13 1.91E-03 RGD1564472 ENSRNOT00000049320 -0.07 0.03 RGD1564535 ENSRNOT00000062001 0.08 0.02 RGD1564579 XM_215057 -0.19 2.15E-05 RGD1564626 ENSRNOT00000058774 0.09 0.02 RGD1564664 XM_575179 -0.37 4.51E-05 RGD1564704 ENSRNOT00000044808 0.11 4.10E-04 RGD1564719 ENSRNOT00000033396 0.09 0.05 RGD1564799 DY471778 -0.42 5.83E-37 RGD1564804 ENSRNOT00000009044 0.12 1.24E-03 RGD1564865 XM_574074 -0.11 4.99E-03 RGD1564887 703124629T1 -0.1 1.29E-03 RGD1565002 ENSRNOT00000007645 0.12 3.21E-06 RGD1565033 XM_573212 0.14 1.66E-06 RGD1565082 ENSRNOT00000005369 -0.09 0.04 RGD1565289 XM_001065804 0.08 1.93E-04 RGD1565301 ENSRNOT00000046475 -0.09 0.02 RGD1565306 XM_001077524 0.08 0.01 RGD1565362_predicted ENSRNOT00000010211 -0.15 1.79E-03 RGD1565416 704287813J1 -0.1 3.32E-03 RGD1565419 ENSRNOT00000034254 0.14 8.76E-06 RGD1565474 ENSRNOT00000024428 -0.08 1.75E-03 RGD1565486 704219127H1 0.04 0.04 Diabetes Page 256 of 288

RGD1565496 ENSRNOT00000041915 -0.11 1.68E-06 RGD1565560 ENSRNOT00000006659 -0.12 0.03 RGD1565561 ENSRNOT00000059774 0.14 5.35E-04 RGD1565616 ENSRNOT00000028842 -0.18 3.28E-06 RGD1565660 XM_577319 -0.1 0.02 RGD1565675 ENSRNOT00000000123 0.09 0.04 RGD1565713 ENSRNOT00000048255 -0.14 0.02 RGD1565731 XM_001065613 0.13 2.53E-03 RGD1565800 ENSRNOT00000038293 -0.13 5.86E-03 RGD1565883 ENSRNOT00000001588 -0.16 2.08E-03 RGD1565975 XM_238038 -0.07 4.34E-03 RGD1566149 XM_573150 0.12 3.72E-03 RGD1566155 ENSRNOT00000040175 0.08 5.69E-04 RGD1566189 XM_001077872 0.18 3.59E-03 RGD1566265 BQ200454 0.14 3.30E-04 RGD1566319 XM_578496 0.05 0.05 RGD1566320 ENSRNOT00000055588 0.14 5.23E-08 RGD1566325 ENSRNOT00000024149 -0.11 0.02 RGD1566355 ENSRNOT00000007173 0.07 9.51E-03 RGD1566370 BC089998 0.2 8.11E-06 RGD1566386 ENSRNOT00000028927 0.11 4.38E-03 RGD1566396 ENSRNOT00000010672 0.08 2.78E-05 RGD708545 NM_001033971 0.14 8.67E-08 RGD735065 NM_199379 -0.05 4.85E-03 RGD735112 NM_199391 0.15 1.92E-06 Rgs16 NM_001077589 -0.26 3.32E-04 Rgs2 ENSRNOT00000005156 0.32 7.31E-09 Rgs3 BC085710 0.13 0.02 Rhbdd1 NM_001024891 -0.1 0.03 Rhbdd2 ENSRNOT00000001962 0.07 0.04 Rhbdf1 NM_001030034 -0.12 0.03 Rhbdl2 XM_001055537 -0.08 6.78E-03 Rhebl1 NM_182825 -0.09 0.01 Rhoa BC061732 -0.06 2.85E-04 Rhobtb2 NM_001013133 0.13 2.37E-05 Rhoc EV779899 0.08 0.02 Rhoq NM_053522 -0.21 1.42E-12 Rhov NM_138542 0.15 3.10E-05 Rhpn1 XM_216954 -0.17 0.03 Rilpl1 ENSRNOT00000001401 -0.14 5.72E-03 Rimbp2 ENSRNOT00000033379 -0.08 5.81E-05 Rims1 NM_052829 0.28 4.30E-17 Riok2 NM_001009687 0.11 4.43E-07 Riok3 ENSRNOT00000039377 0.09 1.68E-06 Ripk5 NM_199463 -0.15 1.67E-05 Rit1 ENSRNOT00000027455 0.09 2.23E-04 Rit2 CF976521 0.18 9.44E-04 Page 257 of 288 Diabetes

Rkhd2 XM_001062342 -0.21 2.59E-16 Rmi1 ENSRNOT00000025812 -0.1 0.01 Rnase1_predicted NM_001013232 0.08 0.03 Rnaseh1 NM_001013097 0.08 0.01 Rnaseh2a NM_001013234 -0.16 1.91E-06 Rnaseh2b NM_001007007 0.05 0.04 Rnasek ENSRNOT00000025767 -0.13 9.58E-04 Rnaset2 ENSRNOT00000017601 0.05 6.53E-03 Rnd3 NM_001007641 0.13 4.39E-03 Rnf10 CB576295 0.07 0.02 Rnf11l ENSRNOT00000021681 0.08 2.13E-05 Rnf121 CN542239 0.14 8.35E-06 Rnf125 ENSRNOT00000021136 -0.2 6.04E-10 Rnf135 NM_001012010 -0.26 1.87E-16 Rnf138 NM_053588 -0.3 4.73E-17 Rnf139 ENSRNOT00000011891 0.18 2.37E-13 rnf141 NM_001001800 -0.1 0.03 Rnf144a g6163684 -0.13 4.49E-03 Rnf145 ENSRNOT00000006436 -0.1 7.93E-09 Rnf149 ENSRNOT00000018684 0.14 3.10E-03 Rnf150 ENSRNOT00000004621 -0.09 6.00E-03 Rnf152 ENSRNOT00000019921 -0.14 4.38E-03 Rnf166 NM_001002279 -0.15 9.59E-03 Rnf17 ENSRNOT00000010795 0.1 4.37E-03 Rnf186 ENSRNOT00000023358 -0.08 0.03 Rnf19a CB545346 -0.18 1.56E-12 Rnf217 XM_001057827 0.12 6.19E-04 Rnf26 XM_236181 0.14 0.01 Rnf4 CF110357 -0.05 2.07E-03 Rnf6 ENSRNOT00000001282 0.12 5.71E-03 Rnf8 NM_001025727 -0.16 7.34E-07 Rnft1 ENSRNOT00000005064 0.14 1.72E-03 Rnmt NM_001008299 -0.4 1.21E-24 Rnps1 NM_001011890 -0.29 0 Rnuxa NM_173133 -0.14 1.19E-05 Robo2 ENSRNOT00000044546 0.29 1.16E-12 Rock2 AI511372 -0.15 2.25E-05 rp9 ENSRNOT00000046509 0.18 6.75E-06 Rpain NM_001033060 0.07 0.03 Rpap2 NM_001013987 -0.06 0.02 Rpe NM_001033903 0.13 4.73E-05 Rph3al NM_133591 -0.11 1.04E-05 Rpia ENSRNOT00000007927 -0.15 4.01E-07 Rpl15 NM_139114 -0.1 6.10E-06 Rpl21 NM_053330 0.06 0.04 Rpl3 NM_198753 -0.04 0.04 Rpl31 ENSRNOT00000033733 0.1 0.02 Diabetes Page 258 of 288

Rpl41 XM_001070992 0.07 0.04 Rpl7l1 ENSRNOT00000021803 0.08 2.88E-03 Rpo1-1 NM_001008330 0.08 6.85E-03 Rpo1-4 NM_031772 0.07 0.05 Rpp21 NM_001002831 0.1 5.52E-04 Rpp38 NM_001033063 0.07 3.60E-03 Rps11 NM_031110 -0.2 2.36E-33 Rps15 NM_017151 -0.05 0.02 Rps19bp1 ENSRNOT00000024085 0.05 0.02 Rps6ka3 ENSRNOT00000008938 0.16 2.53E-04 Rps6kb2 NM_001010962 0.08 0.04 Rps7 NM_031570 0.08 8.46E-03 Rraga NM_053973 0.07 2.16E-03 RragB 702955022H1 -0.33 6.78E-12 Rragc NM_001048184 -0.18 6.53E-09 Rras2 NM_001013434 -0.43 5.36E-27 Rrbp1 BI290094 0.12 0.02 Rrm1 BP499608 -0.23 0.02 Rrn3 BC086552 -0.08 4.57E-03 Rrp9 XM_001071554 0.13 2.94E-08 RT1-A1 NM_001008827 -0.06 6.33E-03 RT1-Aw2 NM_012645 -0.18 1.15E-03 RT1-DOb NM_001008846 -0.11 0.01 RT1-Ke4 NM_001008885 0.07 0.03 RT1-O NM_001008856 -0.09 0.04 RT1-S3 NM_001008886 -0.12 5.77E-04 Rtbdn XM_001071055 -0.1 2.49E-03 Rtel1 ENSRNOT00000055028 -0.17 2.38E-06 Rtn1 DV213382 0.11 0.04 Rtn3 NM_080909 -0.23 6.95E-25 Rtn4 NM_031831 -0.09 3.38E-07 Rtn4r NM_053613 -0.08 9.31E-03 Rtp4 ENSRNOT00000043660 -0.2 1.94E-03 Rttn ENSRNOT00000058160 -0.11 3.70E-03 Rundc1 XM_001081465 0.09 0.01 Runx3 AI235298 -0.11 9.16E-03 Ruvbl1 NM_147177 0.09 4.13E-04 Rxrb NM_206849 -0.14 2.01E-03 Ry1 ENSRNOT00000048399 0.07 0.03 Ryk NM_080402 0.14 2.27E-08 Ryr2 ENSRNOT00000023601 -0.14 0.01 Ryr3 ENSRNOT00000040306 0.08 0.04 S100a1 NM_001007636 0.08 0.01 Sacm1l NM_053798 0.1 9.38E-05 Sae1 NM_001012063 0.06 0.02 Sall1 XM_226329 -0.11 1.63E-03 Samd10 BC099100 0.06 0.03 Page 259 of 288 Diabetes

Samd12 ENSRNOT00000031679 0.11 2.50E-03 Samm50 NM_001004241 0.07 1.82E-03 Sap130 ENSRNOT00000022761 0.1 0.02 Sap30l ENSRNOT00000003473 -0.2 1.34E-06 Saps1 ENSRNOT00000024400 0.08 7.85E-03 Sar1a CK597097 0.08 0.05 Sardh NM_053664 -0.12 3.55E-03 Sart3 ENSRNOT00000000891 -0.26 3.92E-21 Sass6 ENSRNOT00000020757 -0.17 0.01 Sat1 NM_001007667 0.2 7.99E-07 Sav1 CK597558 0.17 7.90E-03 Sbds NM_001008289 -0.04 0.01 Sbf1 ENSRNOT00000040113 0.13 2.04E-03 Sc5d AB052846 0.13 8.85E-05 Scamp1 ENSRNOT00000014602 -0.12 7.78E-07 Scamp3 ENSRNOT00000027815 0.13 5.90E-03 Scamp5 NM_031726 0.11 3.65E-03 Scap NM_001100966 -0.17 5.29E-04 Scarb2 NM_054001 0.06 0.02 Scd2 NM_031841 -0.18 6.38E-03 Schip1 ENSRNOT00000057473 0.07 0.02 Sclt1 NM_153740 0.12 1.66E-03 Scn3a NM_013119 -0.13 4.65E-03 Scn3b NM_139097 -0.11 8.79E-04 Sco1 ENSRNOT00000044116 0.11 3.21E-04 Scoc NM_001013235 0.11 2.49E-07 Scpep1 NM_133383 0.12 2.96E-11 Scye1 BF547226 0.05 0.03 Scyl1bp1 ENSRNOT00000005148 0.08 6.33E-03 Sdad1 NM_001006958 0.12 1.50E-09 Sdc1 M81785 -0.05 0.02 Sdc2 NM_013082 0.1 2.32E-05 Sdccag10 NM_001013199 0.07 0.05 Sdccag8 NM_177929 0.11 0.02 Sdf2 ENSRNOT00000016297 0.08 3.47E-04 Sdf4 NM_130412 0.04 0.04 Sdhc NM_001005534 0.04 0.05 Sec11c NM_153628 0.05 0.03 Sec13 NM_001006978 0.09 4.04E-04 Sec14l1 ENSRNOT00000003690 0.08 0.04 Sec22a NM_057147 0.07 0.01 Sec22b NM_001025686 0.1 3.68E-04 Sec23a XM_347236 0.28 7.68E-10 Sec23b ENSRNOT00000011553 0.08 1.13E-03 Sec23ip ENSRNOT00000027665 0.07 0.05 Sec24a ENSRNOT00000006356 0.1 0.04 Sec61a1 NM_199256 0.11 5.09E-03 Diabetes Page 260 of 288

Sec61a2 XM_341558 0.07 0.04 Sec61b ENSRNOT00000008329 0.06 2.03E-04 Sec63 ENSRNOT00000000345 0.14 3.60E-05 Secisbp2 NM_024002 -0.07 8.45E-03 Sel1l NM_177933 0.11 0.03 Selk NM_207589 0.05 0.02 SELS NM_173120 0.17 1.73E-16 Sema4a NM_001012078 -0.07 0.02 Sema4b ENSRNOT00000030914 -0.27 6.98E-11 Sema4c ENSRNOT00000021956 0.07 0.02 Sema4f NM_019272 0.14 5.75E-03 Sema4g ENSRNOT00000019956 -0.1 8.70E-04 Senp2 NM_023989 -0.11 0.02 Senp3 ENSRNOT00000018670 0.12 8.11E-03 Senp7 ENSRNOT00000044177 -0.31 8.82E-15 Senp8 NM_001012355 0.08 5.40E-03 Sephs1 BG668465 -0.28 0 Sephs2 NM_001079889 0.06 0.02 Sepp1 ENSRNOT00000021292 -0.2 7.47E-03 Serac1 XM_574308 0.08 2.94E-05 Serf2 NM_001098782 0.33 4.88E-17 Sergef ENSRNOT00000015352 0.07 0.03 Serp1 NM_030835 0.04 0.03 Serpina11 NM_001008776 0.11 9.26E-03 Serpina4 NM_145097 -0.08 0.01 Serpinb6a NM_199085 0.08 7.14E-04 Serping1 NM_199093 -0.21 2.41E-03 Serpini1 BC061536 0.23 6.37E-19 Sesn1 ENSRNOT00000000330 0.15 5.63E-07 Setd4 ENSRNOT00000002308 0.07 0.02 Setd6 ENSRNOT00000016626 0.13 3.98E-03 Sez6 ENSRNOT00000012627 -0.11 0.02 Sf3b3 CA505170 -0.06 0.01 Sf4 XM_001068287 -0.32 3.77E-07 Sfpq 704240832J1 -0.38 2.48E-42 Sfrs1 DV721035 -0.37 2.49E-31 Sfrs10 BC070948 -0.07 1.43E-03 Sfrs12ip1 NM_001008373 0.11 2.59E-03 Sfrs18 XM_001055560 0.11 5.41E-03 Sfrs3 NM_001047907 -0.29 1.18E-23 Sfrs6 DV724358 -0.11 8.15E-03 Sfrs7 CD371819 -0.07 0.04 Sfrs9 NM_001009255 0.11 4.49E-06 Sft2d1 NM_001008302 0.07 1.32E-05 Sft2d2 NM_001034011 -0.08 6.55E-03 Sft2d3 XM_001059433 0.21 5.04E-14 Sfxn2 CK226786 0.19 4.56E-07 Page 261 of 288 Diabetes

Sfxn4 ENSRNOT00000054674 0.14 3.14E-04 Sfxn5 NM_153298 -0.08 3.86E-03 Sgk1 NM_019232 0.14 0.03 Sgk3 XM_001060531 -0.34 1.52E-10 Sgsm1 ENSRNOT00000000898 -0.13 6.54E-04 Sgtb NM_181629 -0.14 0.02 Sh2b2 NM_053669 -0.25 5.05E-03 Sh2b3 NM_031621 0.16 4.28E-05 Sh2d5 XM_001070433 -0.3 1.81E-03 Sh3bp4 NM_022693 0.15 0.04 Sh3bp5 NM_054011 -0.13 4.03E-03 Sh3gl2 ENSRNOT00000008999 0.16 1.24E-03 Sh3gl3 BF405216 -0.12 0.04 Sh3glb1 NM_001011929 0.07 6.47E-04 Sh3kbp1 AF131867 -0.07 0.02 Shank2 NM_133441 -0.22 1.57E-04 Shbg NM_012650 -0.09 0.04 Shc2_predicted ENSRNOT00000010714 -0.23 9.65E-06 Shc3 ENSRNOT00000019442 -0.05 0.05 Shfm1 ENSRNOT00000013841 0.04 0.02 Shoc2 NM_001013155 -0.11 2.61E-03 Shox2 ENSRNOT00000046307 -0.12 0.05 Shpk NM_001033682 -0.17 1.99E-03 Siah2 NM_134457 0.09 0.02 Sidt2 ENSRNOT00000024240 0.08 6.36E-03 Sil1 NM_199376 -0.08 9.34E-03 Sin3a ENSRNOT00000044479 -0.1 0.01 Sirt1 ENSRNOT00000000427 -0.12 0.02 Sirt5 NM_001004256 0.07 0.01 Sirt7 ENSRNOT00000054951 0.21 1.19E-09 Six3 NM_023990 -0.2 1.35E-03 Skap1 NM_173311 0.1 0.03 Skap2 NM_130413 -0.04 0.05 Skip NM_001013859 -0.17 4.94E-05 Slain2 XM_001076917 -0.34 1.01E-11 Slc10a3 NM_001024368 0.1 0.02 Slc11a2 NM_013173 0.09 3.46E-03 Slc12a2 BM386472 0.21 4.92E-04 Slc12a4 NM_019229 -0.22 0.01 Slc12a6 BF287829 -0.16 1.33E-04 Slc16a1 NM_012716 0.22 8.10E-03 Slc16a13 NM_001005530 0.1 7.16E-05 Slc17a6 NM_053427 0.12 3.67E-03 Slc1a1 D63772 -0.17 8.97E-05 Slc1a3 NM_019225 0.13 8.56E-03 Slc22a5 NM_019269 0.15 2.30E-05 Slc24a2 702958101J1 -0.23 1.64E-05 Diabetes Page 262 of 288

Slc24a3 XM_001054941 0.19 4.83E-03 Slc24a6 NM_001017488 -0.18 7.41E-05 Slc25a14 NM_053501 0.13 1.01E-08 Slc25a15 NM_001047880 -0.08 0.02 Slc25a16 ENSRNOT00000029576 0.1 0.04 Slc25a19 NM_001007674 0.12 1.23E-09 Slc25a20 X97831 -0.88 8.11E-40 Slc25a24 ENSRNOT00000027765 0.19 1.02E-04 Slc25a25 NM_145677 0.15 9.45E-05 Slc25a32 ENSRNOT00000006029 0.12 9.19E-05 Slc25a35 ENSRNOT00000006597 0.34 5.77E-05 Slc25a37 NM_001013996 0.18 3.48E-12 Slc25a40 NM_001037186 0.14 4.25E-12 Slc26a1 NM_022287 -0.13 7.12E-03 Slc27a2 NM_031736 -0.08 0.02 Slc29a3 NM_181639 0.14 2.91E-03 Slc29a4 ENSRNOT00000001477 -0.12 0.02 Slc2a1 NM_138827 0.08 9.61E-03 Slc2a4 CK843679 -0.18 2.71E-14 Slc2a6 ENSRNOT00000008034 -0.19 6.16E-12 Slc30a4 NM_172066 0.17 2.57E-13 Slc30a5 ENSRNOT00000025506 0.11 1.83E-07 Slc30a8 ENSRNOT00000006410 0.11 3.29E-03 Slc31a1 NM_133600 0.1 1.67E-03 Slc35a3 NM_001012082 0.23 1.62E-09 Slc35a4 NM_147140 0.1 2.03E-06 Slc35b4 ENSRNOT00000012179 0.1 1.72E-03 Slc35c1 ENSRNOT00000010278 0.19 9.37E-09 Slc35d2 ENSRNOT00000036212 0.2 1.13E-08 Slc35e1 703865440J1 0.12 1.66E-03 Slc35e3 BC091412 0.14 1.78E-07 Slc35f5 ENSRNOT00000004581 0.13 8.43E-08 Slc36a1 NM_130415 0.07 3.16E-03 Slc37a1 NM_001011944 -0.11 6.08E-04 Slc38a1 NM_138832 0.13 4.72E-04 Slc38a2 NM_181090 -0.21 1.96E-05 Slc38a6 NM_001013099 0.13 0.03 Slc38a9 NM_001035251 0.17 1.67E-06 Slc39a13 NM_001039196 0.12 5.74E-06 Slc39a6 NM_001024745 -0.07 9.90E-03 Slc3a2 g14884771 -0.1 0.02 Slc41a2 ENSRNOT00000011572 0.18 0.01 Slc45a4 ENSRNOT00000032620 0.11 9.41E-05 Slc4a1ap XM_001067937 0.08 6.46E-03 Slc5a3 NM_053715 -0.21 0.02 Slc6a15 NM_172321 0.12 4.69E-03 Slc6a20 703956716J1 -0.15 0.05 Page 263 of 288 Diabetes

Slc6a6 703206181J2 0.1 0.02 Slc6a8 CK843382 0.1 1.95E-03 Slc7a1 ENSRNOT00000001234 0.1 0.03 Slc7a4 ENSRNOT00000002560 0.07 0.02 Slc7a5 NM_017353 -0.22 0.04 Slc7a6 ENSRNOT00000027117 0.17 1.87E-23 Slc7a6os ENSRNOT00000027200 0.06 3.97E-03 Slc8a1 AY245281 -0.13 8.36E-03 Slc8a2 NM_078619 -0.23 4.74E-03 Slc9a2 NM_012653 0.19 1.40E-14 Slc9a3r1 AI706654 -0.2 0.02 Slc9a6 ENSRNOT00000001171 0.16 7.92E-07 Slco3a1 AI101171 -0.12 9.18E-03 Slit1 NM_022953 -0.1 9.53E-03 Slit2 ENSRNOT00000005477 -0.17 7.09E-04 Slitrk5 ENSRNOT00000057692 0.2 7.99E-06 Slitrk6 ENSRNOT00000038433 0.18 5.86E-06 Slk CK228000 -0.17 1.38E-05 Smad2 NM_019191 0.04 0.04 Smad4 AF056002 -0.22 8.30E-11 Smad5 NM_021692 0.15 1.73E-08 Smagp BC101910 -0.11 1.19E-03 Smap2 BF404303 -0.05 0.04 Smarca2 NM_001004446 -0.07 9.78E-03 Smarca5 ENSRNOT00000024568 -0.15 4.54E-10 Smarcd1 ENSRNOT00000043163 -0.15 9.80E-05 Smarcd3 NM_001011966 -0.08 0.02 Smarce1 NM_001024993 0.08 6.64E-04 Smc6l1 XM_001068591 0.1 7.26E-04 Smcr7 ENSRNOT00000023838 0.07 0.04 Smcr7l g3637964 0.06 0.04 Smn1 NM_022509 0.12 8.74E-08 Smpd1 NM_001006997 -0.3 1.29E-32 Smpd3 NM_053605 -0.12 6.83E-09 Smurf2 ENSRNOT00000019781 0.19 7.14E-12 Smyd2 ENSRNOT00000004783 0.05 0.03 Smyd5 ENSRNOT00000020909 0.14 2.12E-03 Snap29 NM_053810 0.11 1.19E-05 Snapap AA799709 0.05 0.03 Snapc1 ENSRNOT00000012361 0.18 4.94E-11 Snapc3 NM_001013212 0.09 0.02 Snapc5 AA892538 0.16 7.67E-05 Snca NM_019169 0.21 1.19E-08 Snf1lk ENSRNOT00000001579 0.36 6.85E-17 Snf8 NM_001007804 0.06 1.76E-03 Snhg8 ENSRNOT00000061204 0.08 7.85E-03 Snip1 NM_001014069 0.09 3.50E-04 Diabetes Page 264 of 288

Snrpa NM_001008303 -0.14 8.01E-14 Snrpc ENSRNOT00000000586 0.05 0.05 Snrpd2 ENSRNOT00000021221 0.07 0.03 Snx13 704238932J1 0.19 4.21E-10 Snx16 NM_022289 0.26 6.27E-25 Snx2 XM_214539 0.06 4.35E-03 Snx27 NM_152847 -0.33 7.95E-14 Snx4 ENSRNOT00000002432 -0.16 3.54E-13 Snx5 ENSRNOT00000008934 0.05 7.81E-03 Snx7 NM_001012083 0.23 1.28E-15 Snx8 ENSRNOT00000001696 0.15 1.30E-09 Soat1 704244751J1 0.17 6.87E-07 Socs2 NM_058208 -0.29 3.28E-05 Socs4 ENSRNOT00000015120 0.21 4.68E-07 Socs5 702034691H1 0.08 1.03E-05 Socs6 XM_001063512 0.07 0.02 Sod2 BQ782213 -0.3 9.97E-05 Sos1 ENSRNOT00000009359 -0.22 1.77E-10 Sox4 BI297183 -0.07 2.58E-03 Sp110 BQ782539 -0.15 3.39E-07 Spaca5 XM_234525 0.11 3.53E-03 Spast ENSRNOT00000039375 0.06 9.95E-03 Spata2 NM_053675 0.08 9.75E-03 Spata2L ENSRNOT00000021968 0.07 0.03 Spats2 ENSRNOT00000040072 -0.09 1.08E-04 Spc25 NM_001009654 -0.25 3.20E-13 Spdef XM_001069981 -0.1 0.03 Specc1l ENSRNOT00000001764 -0.13 1.69E-03 Spg7 NM_181388 -0.1 1.63E-03 Sphk2 NM_001012066 0.1 5.42E-03 Spin2 ENSRNOT00000052281 0.11 3.92E-04 Spint1 NM_001004265 0.06 7.86E-03 Spire1 ENSRNOT00000032696 0.1 0.01 Spire2 ENSRNOT00000022823 -0.15 5.58E-03 Spnb2 BP495933 -0.13 0.02 Spp2 NM_053577 -0.19 3.27E-03 Sppl2a ENSRNOT00000015568 0.07 2.68E-03 Sppl2b NM_001014200 0.17 4.08E-04 Sppl3 BQ781686 -0.12 1.85E-05 Spry4 AW914942 0.08 4.49E-03 Spryd3 ENSRNOT00000055320 -0.15 1.50E-04 Sptlc1 ENSRNOT00000014546 0.09 2.85E-06 Sqle NM_017136 0.18 7.77E-14 Sra1 NM_183329 0.14 5.44E-16 Srd5a3 NM_001013990 0.11 3.43E-05 Srf g11380549 0.15 2.01E-04 Srm NM_053464 0.11 4.46E-05 Page 265 of 288 Diabetes

Srp14 ENSRNOT00000009866 0.04 0.03 Srp19 ENSRNOT00000027418 -0.09 0.02 Srp54 NM_053871 0.11 2.65E-04 Srp68 ENSRNOT00000012436 0.06 6.67E-03 Srpr NM_001034150 0.07 5.59E-03 Ss18l1 AW921144 0.11 8.79E-04 Ssb NM_031119 0.06 0.02 Ssbp1 NM_183328 0.07 0.02 Ssh3 NM_001012217 0.14 2.39E-03 Sspn ENSRNOT00000002465 -0.09 0.02 Ssr2 XM_001070197 0.08 1.15E-04 Ssr3 AY724496 -0.07 0.03 Ssx2ip NM_175597 -0.41 0 St3gal5 CK473297 0.2 1.25E-09 St3gal6 AJ626743 0.12 4.14E-05 St5 XM_219273 -0.19 5.39E-04 St6gal1 NM_147205 -0.24 5.53E-06 St8sia1 NM_012813 0.08 0.03 Stambp NM_138531 0.06 0.01 Stard3nl NM_001008298 0.1 1.45E-03 Stard5 ENSRNOT00000015320 0.29 1.24E-08 Stard7 XM_238280 0.07 2.48E-05 Stat1 NM_032612 -0.1 7.76E-07 Stat2 NM_001011905 0.09 6.37E-04 Stau2 AY684790 -0.09 0.02 Steap3 AW530939 0.12 3.15E-03 Stim2 ENSRNOT00000058996 -0.18 2.06E-06 Stk10 U33472 0.13 0.01 Stk17b NM_133392 0.14 1.90E-03 Stk24 ENSRNOT00000034723 -0.06 0.02 Stk25 NM_184049 0.07 0.02 Stk3 NM_031735 0.09 1.70E-04 Stk4 BC088330 0.13 0.01 Stmn1 NM_017166 -0.1 2.64E-05 Stmn3 NM_024346 0.08 0.03 Stoml2 NM_001031646 0.08 1.45E-04 Ston2 ENSRNOT00000005881 -0.13 6.56E-03 Strap NM_001011969 -0.05 5.73E-03 Strbp ENSRNOT00000013832 0.07 0.03 Strn NM_019148 -0.11 2.43E-04 Strn3 NM_001029897 0.08 1.43E-03 Strn4 BF408712 -0.19 8.60E-05 Stx12 NM_022939 -0.06 0.03 Stx18 NM_001012151 0.12 2.37E-05 Stx3 NM_031124 0.07 0.04 Stx6 NM_031665 0.12 1.12E-04 Stx7 NM_021869 0.05 0.04 Diabetes Page 266 of 288

Stxbp1 ENSRNOT00000021189 -0.14 7.33E-03 Stxbp3 NM_053637 -0.1 0.01 Sucla2 ENSRNOT00000023516 -0.14 1.56E-03 Suclg2 ENSRNOT00000007552 0.08 0.01 Suds3 CO574703 -0.1 2.86E-08 Sufu NM_001024899 0.1 0.02 Sult2b1 NM_001039665 -0.28 5.48E-11 Sumf1 ENSRNOT00000009008 0.16 7.70E-09 Supt16h ENSRNOT00000016288 -0.09 0.03 Supv3l1 NM_001012462 0.07 0.02 Sv2a NM_057210 -0.33 2.40E-06 Svil XM_341540 -0.18 5.39E-03 Swap70 ENSRNOT00000013276 0.07 0.04 Syap1 NM_001004253 0.11 8.38E-05 Sycp2 NM_130735 -0.16 1.08E-03 Syne1 BP483578 -0.08 0.01 Synj2bp BQ783056 0.15 4.02E-06 Synpo2 ENSRNOT00000019931 0.2 2.66E-07 Syt1 ENSRNOT00000048880 0.35 1.03E-04 Syt13 NM_030839 -0.28 1.56E-04 Taar8b NM_175601 -0.13 0.02 Tac1 NM_012666 0.21 1.64E-08 Tacc2 NM_001004418 -0.16 4.39E-04 Tacc3 NM_001004424 -0.11 4.74E-07 Tada1l ENSRNOT00000058689 -0.07 3.22E-03 Tada2l NM_001012141 -0.07 0.04 Taf1 ENSRNOT00000003494 -0.07 8.20E-03 Taf11 NM_001008350 -0.12 6.63E-08 Taf13 ENSRNOT00000027530 0.15 1.24E-05 Taf2 BC091307 -0.07 0.03 Taf6l ENSRNOT00000026284 0.08 0.04 Taf7 ENSRNOT00000027125 0.09 0.03 Taf9 NM_001012463 0.15 9.35E-07 Taf9b NM_133615 0.08 1.04E-05 Taok3 BE109597 -0.16 7.34E-05 Tap2 NM_032056 -0.11 1.49E-04 Tarbp2 NM_001034941 0.11 9.01E-05 Tarsl2 DV726074 0.07 3.23E-03 Tas1r1 ENSRNOT00000013385 -0.12 0.04 Tas1r2 AI103143 -0.12 2.53E-03 Tasp1 XM_001080195 0.08 7.09E-03 Tax1bp3 NM_001025419 -0.09 2.69E-03 Tbc1d10a NM_001015022 0.1 3.18E-03 Tbc1d7 ENSRNOT00000019089 -0.09 0.04 Tbca NM_001013245 0.06 1.22E-03 Tbcc 703906453J1 0.11 3.57E-06 Tbk1 ENSRNOT00000009260 0.1 1.70E-04 Page 267 of 288 Diabetes

Tbl3 NM_001008277 -0.08 3.31E-03 Tbp NM_001004198 0.06 0.01 Tbpl2 NM_001099361 -0.13 8.77E-03 Tbrg4 NM_001012154 0.07 1.94E-03 Tbx15 ENSRNOT00000026570 0.08 0.04 Tc2n NM_001025152 0.19 3.09E-07 Tceal8 NM_001014275 0.13 5.56E-05 Tceb1 BC060566 -0.16 5.28E-08 Tceb2 NM_031129 0.07 3.67E-03 Tceb3 NM_017103 0.17 4.80E-08 Tcf20 XM_001077683 -0.09 0.02 Tcfcp2 ENSRNOT00000055374 -0.06 0.01 Tcfcp2l2 NM_001037354 -0.39 2.50E-04 Tcfe3 AW915039 -0.12 0.03 Tcp11l2 NM_001017458 -0.22 2.66E-07 Tcta NM_001014005 0.07 8.44E-03 Tctex1d2 ENSRNOT00000002397 -0.15 2.58E-10 Tctn3 ENSRNOT00000020455 0.2 3.51E-16 Tdp1 NM_001031657 0.06 0.03 Tdpoz1 ENSRNOT00000042513 0.09 0.04 Tdrd7 NM_138871 -0.35 1.83E-19 Tect2 NM_001080782 -0.14 1.43E-08 Terf1 NM_001012464 -0.08 0.04 Tes BE104149 0.09 6.49E-04 Tesk2 NM_133396 0.09 0.03 Tex10 ENSRNOT00000011401 0.07 0.03 Tex261 NM_001017537 0.12 0.02 Tex264 NM_001007665 -0.25 7.76E-20 Tex9 ENSRNOT00000032268 0.08 7.34E-03 Tfb1m NM_181474 0.19 8.61E-08 Tff3 NM_013042 -0.22 5.50E-05 Tfpi BC087020 0.25 5.65E-05 Tfpt NM_138870 0.07 6.98E-03 Tgfb1 NM_021578 0.11 0.02 Tgif1 NM_001015020 -0.18 1.27E-04 Tgm2 NM_019386 -0.42 0 Thap1 NM_001008340 -0.13 1.77E-09 Thap3 ENSRNOT00000055487 0.07 0.04 Them2 ENSRNOT00000024878 0.14 2.23E-05 Thoc1 NM_001047850 0.06 0.02 Thoc3 ENSRNOT00000000116 0.08 5.99E-05 Thoc4 AI171574 0.07 2.17E-03 Thoc5 NM_001012153 0.07 3.53E-03 Thoc7 ENSRNOT00000010675 0.05 0.02 Thop1 NM_172075 0.12 0.05 Thra NM_031134 -0.17 2.55E-05 Thrb ENSRNOT00000008989 0.16 0.02 Diabetes Page 268 of 288

Thy1 NM_012673 0.13 7.53E-03 Thyn1 NM_001007661 0.05 0.01 Tia1 BF522735 -0.09 2.44E-03 Tifa NM_001014044 0.14 0.01 Tifab NM_001025029 0.15 0.03 Timm13 NM_145781 0.09 2.16E-03 Timm17b ENSRNOT00000037066 0.1 0.04 Timm22 ENSRNOT00000010778 0.09 2.58E-05 Timm44 BE104842 -0.08 0.03 Timm8a1 AF150082 0.13 4.15E-04 Timm8b NM_022541 0.13 1.00E-08 Timm9 ENSRNOT00000010871 -0.48 0 Timp4 AI411222 0.11 5.46E-06 Tinf2 NM_001006962 0.07 3.52E-03 Tipin NM_001025287 -0.26 0 Tjp3 ENSRNOT00000027847 -0.14 0.02 Tle2 NM_001039013 -0.16 0.03 Tle3 BC097419 0.13 0.02 Tle4 NM_019141 -0.17 1.31E-10 Tlk1 ENSRNOT00000012383 0.12 0.02 Tm2d1 ENSRNOT00000009897 0.11 8.89E-07 Tm2d2 NM_001017444 0.16 8.09E-09 Tm2d3 ENSRNOT00000015287 0.09 2.11E-07 Tm6sf1 ENSRNOT00000026714 0.2 3.68E-11 Tm9sf2 NM_001005554 0.1 7.75E-06 Tmed1 NM_001013432 0.13 1.70E-05 Tmed10 NM_053467 0.08 1.12E-05 Tmed5 CK478784 0.19 1.97E-07 Tmed9 NM_001009703 0.15 2.25E-07 Tmem1 ENSRNOT00000032240 -0.05 9.70E-03 Tmem106b NM_001004267 0.08 7.70E-04 Tmem106c NM_001008358 -0.07 0.04 Tmem109 NM_001007736 -0.12 8.61E-07 Tmem115 ENSRNOT00000032263 0.1 2.51E-03 Tmem120a NM_001010945 0.11 1.90E-05 Tmem123 NM_001014205 0.17 1.38E-03 Tmem126a AI170944 0.16 3.84E-06 Tmem126b ENSRNOT00000038279 0.11 1.05E-04 Tmem134 NM_001078648 0.1 5.95E-03 Tmem135 NM_001013896 -0.11 7.44E-04 Tmem141 ENSRNOT00000033701 0.1 0.01 Tmem147 NM_001038494 0.11 9.36E-05 Tmem14a ENSRNOT00000037489 0.15 5.13E-05 Tmem157 NM_001012350 0.12 2.80E-04 Tmem161b ENSRNOT00000045851 -0.09 0.02 Tmem163 ENSRNOT00000005006 0.07 0.02 Tmem165 NM_001024802 0.12 2.37E-05 Page 269 of 288 Diabetes

Tmem16c XM_001080134 0.08 0.03 Tmem16d ENSRNOT00000009084 0.18 0.01 Tmem175 NM_001013991 0.13 1.58E-05 Tmem177 NM_001037776 0.15 2.74E-10 Tmem184a NM_001025413 -0.09 8.64E-03 Tmem185b XM_001053834 0.05 4.21E-04 Tmem188 ENSRNOT00000020816 0.13 1.21E-03 Tmem189 703893835J1 0.12 4.74E-07 Tmem19 NM_199098 0.07 1.20E-04 Tmem192 NM_001014141 -0.17 1.64E-10 Tmem199 NM_001024992 0.08 1.03E-07 Tmem2 ENSRNOT00000017212 -0.27 2.24E-07 Tmem206 NM_001007679 -0.14 6.19E-04 Tmem208 ENSRNOT00000021723 0.08 3.43E-03 Tmem30a DV718956 -0.29 8.44E-19 Tmem32 XM_001057974 -0.31 1.59E-24 Tmem34 NM_178330 0.1 4.90E-06 Tmem38a ENSRNOT00000015877 -0.14 2.37E-09 Tmem38b NM_001014191 0.15 4.40E-05 Tmem39a NM_001013865 0.08 0.03 Tmem41b NM_001012358 0.08 4.62E-03 Tmem43 NM_001007745 -0.19 7.29E-09 Tmem49 NM_138839 0.17 1.79E-11 Tmem5 NM_001024759 0.08 3.57E-03 Tmem50b NM_001025014 0.13 3.26E-04 Tmem53 ENSRNOT00000025990 0.1 1.86E-03 Tmem55a NM_001024900 0.13 3.37E-04 Tmem55b NM_001014233 -0.18 4.15E-05 Tmem56 XM_001073749 0.28 1.14E-09 Tmem60 ENSRNOT00000018040 0.09 5.15E-05 Tmem62 AI407421 0.1 4.80E-04 Tmem66 CO571211 0.06 0.01 Tmem67 XM_001053339 0.05 0.04 Tmem77 BE099552 0.1 1.51E-04 Tmem85 ENSRNOT00000007612 0.11 5.51E-07 Tmem87b ENSRNOT00000023569 0.11 3.98E-05 Tmem9 ENSRNOT00000013738 -0.44 0 Tmem93 ENSRNOT00000026168 -0.29 0 Tmem97 NM_001008334 0.14 2.48E-05 Tmem9b CA945807 0.13 1.09E-08 Tmod2 g3103039 -0.21 2.05E-06 Tmod3 CA506946 0.06 0.04 Tmpo NM_012887 -0.24 9.59E-17 Tnfrsf12a NM_181086 0.12 6.70E-08 Tnfrsf1a NM_013091 0.1 6.09E-03 Tnfrsf21 ENSRNOT00000015918 0.08 0.02 Tnfsf9 NM_181384 0.08 7.79E-03 Diabetes Page 270 of 288

Tnip1 XM_001073849 -0.14 1.65E-07 Tnks g8506403 0.11 1.67E-03 Tnni3k NM_181769 -0.17 0.02 Tnpo3 AA900078 0.12 1.58E-03 Tob1 NM_133317 0.15 1.92E-06 Tob2 NM_001007146 0.16 5.50E-04 Toe1 BF407150 -0.09 0.04 Tomm40 NM_212520 0.1 1.97E-03 Tomm70a NM_212519 0.07 5.63E-04 Top1 BE115617 0.09 0.03 Topbp1 ENSRNOT00000013265 -0.06 0.04 Tor1aip1 NM_145092 0.13 1.23E-06 Tor1aip2 NM_199100 0.14 3.98E-04 Tor2a NM_001007744 0.11 3.98E-05 Tor3a NM_001009683 0.15 3.08E-05 Tox3 ENSRNOT00000029415 -0.09 6.03E-03 Tox4 NM_173324 0.09 3.41E-04 Tpbg NM_031807 -0.11 0.03 Tpcn1 NM_139332 0.19 4.34E-05 Tpd52 704155427J1 0.1 8.24E-07 Tpk1 XM_001073146 -0.13 0.01 Tpm1 NM_001034071 0.11 1.49E-03 Tpm3 NM_173111 0.06 0.01 Tpo1 NM_133395 -0.26 1.02E-08 Tppp3 NM_001009639 0.12 8.22E-04 Tpst2 NM_001008508 0.08 4.41E-03 Trabd CK843357 0.08 0.01 Traf3 ENSRNOT00000010906 0.15 6.49E-04 Traf3ip2 NM_001044248 -0.14 0.02 Traf4af1 NM_001004264 -0.06 4.49E-03 Traf6 DY472844 -0.25 1.35E-05 Traf7 ENSRNOT00000004192 -0.08 1.22E-04 Tram1 EV768461 0.05 0.02 Tram1l1 ENSRNOT00000013030 0.11 1.69E-04 Trap1 NM_001039001 0.05 0.01 Trappc3 NM_001008376 0.09 5.13E-05 Trappc4 NM_001003708 0.08 1.15E-03 Trdmt1 NM_001031643 -0.12 0.02 Trem2 ENSRNOT00000018351 0.08 0.03 Trex1 NM_001024989 0.08 0.04 Trib2 ENSRNOT00000005774 -0.09 0.05 Trim23 704297763J1 0.07 0.03 Trim25 NM_001009536 -0.19 7.00E-14 Trim26 NM_001011665 0.08 0.01 Trim31 ENSRNOT00000061558 0.08 0.04 Trim33 ENSRNOT00000025600 0.09 0.04 Trim37 XM_001081108 -0.36 1.17E-34 Page 271 of 288 Diabetes

Triobp ENSRNOT00000056206 0.12 0.01 Trip13 NM_001011930 -0.13 1.11E-03 Trmt12 ENSRNOT00000011876 0.11 1.32E-06 Trp53 NM_030989 -0.13 7.12E-03 Trp53i11 ENSRNOT00000057001 -0.25 6.70E-07 Trp53inp1 NM_181084 -0.13 7.86E-03 Trpa1 NM_207608 0.32 5.04E-03 Trpm2 NM_001011559 -0.14 0.03 Trps1 ENSRNOT00000050774 -0.07 0.02 Trpv1 NM_031982 -0.2 3.89E-03 Trub1 NM_001012173 -0.14 6.14E-05 Tsc22d1 ENSRNOT00000058206 -0.07 0.01 Tsc22d3 NM_031345 -0.39 1.24E-14 Tsen2 NM_001014057 0.08 4.56E-03 Tsen34 NM_001006968 -0.2 8.99E-22 Tsn NM_021762 -0.38 6.64E-16 Tspan1 NM_001004236 -0.14 1.52E-03 Tspan12 NM_001015026 0.18 4.23E-03 Tspan13 NM_001013244 0.07 2.24E-05 Tspan2 BC085733 0.14 0.01 Tspan3 NM_001005547 0.04 0.02 Tspan4 NM_001013070 -0.28 3.12E-11 Tspyl1 NM_001013033 0.06 8.97E-04 Tspyl2 ENSRNOT00000004504 0.14 1.80E-03 Tsta3 ENSRNOT00000012306 0.06 1.96E-03 Ttbk2 ENSRNOT00000006019 0.12 1.56E-03 Ttc1 NM_001005529 0.06 0.03 Ttc13 ENSRNOT00000025548 0.1 2.70E-04 Ttc14 ENSRNOT00000015192 0.14 4.49E-07 Ttc22 ENSRNOT00000009582 -0.08 0.02 Ttc25 ENSRNOT00000023497 -0.24 3.17E-07 Ttc7 ENSRNOT00000061747 0.16 1.08E-04 Ttc7b ENSRNOT00000037902 -0.19 3.81E-06 Ttc8 g4132176 -0.08 4.48E-03 Ttc9c NM_001007693 0.06 0.01 Ttf2 CA506469 -0.1 8.96E-03 Ttll7 BF564929 0.26 2.59E-09 Tuba1c NM_001011995 0.06 0.01 Tubgcp2 ENSRNOT00000024573 -0.1 3.47E-03 Tuft1 ENSRNOT00000056437 0.13 0.02 Tulp4 ENSRNOT00000024412 -0.11 0.02 Tusc1 ENSRNOT00000030683 0.13 1.82E-04 Twist1 NM_053530 -0.31 8.80E-18 Twistnb XM_001076417 -0.28 4.97E-16 Txn2 NM_053331 0.05 0.02 Txndc1 NM_001024800 -0.15 6.05E-03 Txndc12 ENSRNOT00000010700 0.1 3.78E-04 Diabetes Page 272 of 288

Txndc15 NM_001024998 -0.21 3.42E-39 Txndc4 EV769485 0.13 3.57E-03 Txnip NM_001008767 -0.37 1.02E-05 Txnl1 NM_080887 -0.12 6.00E-07 Txnrd1 NM_031614 -0.39 2.36E-19 Tysnd1 ENSRNOT00000036719 0.1 0.03 U1snrnpbp NM_001014127 0.1 8.96E-04 Uap1l1 ENSRNOT00000017373 0.12 0.02 Uba1 NM_001014080 0.07 0.02 Uba3 NM_057205 -0.24 1.23E-39 Uba5 NM_001009669 0.08 0.01 Uba52 NM_031687 0.03 0.03 Ubap1 NM_001012190 -0.12 8.83E-03 Ubap2 ENSRNOT00000015920 0.08 8.44E-03 Ubd NM_053299 -0.19 0.05 Ube2d1 XM_001080152 -0.23 8.34E-11 Ube2d3 ENSRNOT00000051335 -0.21 1.06E-15 Ube2e2 BC079134 0.08 4.18E-04 Ube2f NM_001008381 0.09 1.18E-04 Ube2j1 XM_216362 0.14 1.68E-04 Ube2j2 NM_001007655 0.08 2.17E-04 Ube2l6 NM_001024755 0.07 8.38E-04 Ube2q1 ENSRNOT00000028210 0.14 1.30E-06 Ube2q2 ENSRNOT00000019539 0.1 0.03 Ube2t ENSRNOT00000006747 0.06 7.49E-04 Ube2v2 NM_183052 -0.25 1.34E-07 Ube3a CO563495 0.08 0.04 Ube4b XM_233679 0.17 3.49E-04 Ubfd1 NM_001034911 0.17 7.16E-18 Ublcp1 NM_001014117 0.19 6.53E-09 Ubqln1 NM_053747 0.04 0.04 Ubtd2 ENSRNOT00000005486 0.2 1.03E-04 Ubxd1 XM_343670 -0.07 4.20E-03 Ubxd8 NM_001017445 0.1 3.98E-06 Uchl5 BP489316 0.08 2.44E-03 Uchl5ip ENSRNOT00000023305 0.12 6.92E-07 Uck2 ENSRNOT00000005213 0.07 0.02 Ucp1 NM_012682 -0.09 0.03 Ufm1 ENSRNOT00000058116 0.08 0.03 Ufsp2 NM_001014142 0.08 8.72E-04 Ugcg NM_031795 0.15 9.59E-05 Ugcgl1 NM_133596 -0.1 9.27E-04 Ugdh NM_031325 0.07 0.03 Uhrf1 NM_001008882 -0.24 2.93E-22 Unc119 NM_017188 -0.08 1.35E-05 Unc119b EV778603 0.06 2.96E-03 Unc5a NM_022206 -0.2 7.32E-03 Page 273 of 288 Diabetes

Unc5c BQ194600 0.12 1.65E-03 Unc84b ENSRNOT00000046399 -0.14 1.74E-04 Ung NM_001013124 -0.1 3.11E-04 Upb1 NM_053845 -0.14 2.05E-04 Upf3b ENSRNOT00000032618 0.09 0.01 Uqcrb_predicted ENSRNOT00000037030 0.07 0.03 Uqcrc1 NM_001004250 0.08 3.56E-05 Uqcrh NM_001009480 0.07 1.04E-03 Usp11 NM_001008861 0.09 1.01E-05 Usp14 NM_001008301 -0.14 1.91E-12 Usp15 NM_145184 0.12 4.47E-06 Usp19 NM_001001516 0.07 0.04 Usp24 ENSRNOT00000029228 0.11 0.01 Usp3 NM_001025424 -0.08 1.38E-03 Usp31 ENSRNOT00000052246 0.12 4.74E-04 Usp35 ENSRNOT00000055367 0.1 0.02 Usp38 ENSRNOT00000035084 0.06 0.01 Usp39 ENSRNOT00000015562 0.1 5.20E-04 Usp4 BI275233 0.12 0.02 Usp40 ENSRNOT00000035085 -0.11 1.37E-03 Usp42 BM388096 0.06 0.03 Usp48 NM_198785 -0.11 6.11E-04 Usp7 NM_001024790 0.09 0.05 Usp8 ENSRNOT00000015124 0.06 0.03 Usp9x CK839458 -0.16 3.19E-03 Utp3 NM_001012036 0.05 0.02 Utp6 DY471469 0.09 2.55E-06 Utrn AB011666 -0.11 9.22E-03 Uxs1 NM_139336 0.22 1.37E-24 Uxt NM_001006982 0.08 7.11E-03 Vamp1 NM_013090 0.13 0.02 Vamp3 NM_057097 0.14 9.50E-11 Vangl2 ENSRNOT00000006849 -0.13 2.98E-03 Vcl XM_223781 0.18 8.08E-07 Vcpip1 NM_176857 0.08 9.23E-03 Vdac2 NM_031354 -0.12 8.94E-08 Vgll4 NM_001015004 -0.09 1.38E-03 Vil1 ENSRNOT00000021432 0.09 0.01 Vipr1 NM_012685 -0.16 2.28E-03 Visa NM_001005556 0.13 3.16E-03 Vkorc1l1 NM_203338 0.13 6.30E-07 Vldlr NM_013155 0.13 0.02 Vps13a CF115472 -0.17 1.98E-03 Vps13d BP491770 0.06 0.03 Vps16 NM_001005541 -0.07 0.01 Vps24 NM_172331 0.06 6.83E-03 Vps26a NM_001007740 0.2 2.19E-16 Diabetes Page 274 of 288

Vps26b 704158379J1 -0.07 6.45E-05 Vps29 ENSRNOT00000001717 0.08 9.85E-04 Vps36 BG663040 0.15 1.79E-08 Vps37b g14959706 -0.21 3.49E-08 Vps45 NM_172072 0.07 0.02 Vps4a NM_145678 0.06 3.36E-03 Vps4b NM_001025716 0.07 3.70E-03 Vps53 ENSRNOT00000010010 0.07 0.02 Vps54 CV110726 0.14 2.05E-04 Vrk1 NM_001012194 -0.4 0 Vrk2 BP485693 0.1 0.01 Vsig2 ENSRNOT00000042679 -0.09 3.94E-03 Vsnl1 NM_012686 0.17 1.14E-07 Vstm2b ENSRNOT00000023671 -0.18 0.02 Vwa1 NM_001013938 0.1 0.04 Vwce ENSRNOT00000028268 -0.1 4.07E-03 Wars NM_001013170 -0.1 1.10E-05 Wars2 ENSRNOT00000026458 -0.11 0.02 Wbp1 ENSRNOT00000011719 0.07 0.03 Wbp11 NM_001009661 0.07 5.11E-05 Wbscr18 703948844J1 0.11 1.91E-04 Wbscr28 ENSRNOT00000033499 0.05 0.02 Wdfy1 NM_001008331 -0.12 1.80E-03 Wdr26 g3730315 -0.15 3.64E-04 Wdr3 ENSRNOT00000026726 0.05 0.02 Wdr33 BG664800 0.11 6.74E-05 Wdr47 ENSRNOT00000027558 -0.19 5.84E-04 Wdr48 ENSRNOT00000024172 -0.04 0.05 Wdr55 NM_001017932 0.09 1.85E-03 Wdr5b NM_001024766 0.05 0.03 Wdr61 NM_001025743 0.09 2.85E-03 Wdr70 CR462289 0.08 0.04 Wdr73 XM_218815 0.11 1.53E-05 Wdr74 CK841336 0.08 1.50E-03 Wdr75 NM_001047889 0.06 0.02 Wdr76 ENSRNOT00000036209 -0.15 2.62E-05 Wdr77 NM_001008771 -0.11 3.79E-03 Wdr81 XM_001080687 0.09 0.03 Wdsof1 ENSRNOT00000005803 0.08 4.18E-05 Wdsub1 NM_001014179 -0.08 0.02 Wdtc1 ENSRNOT00000011311 -0.11 0.01 Wee1 NM_001012742 -0.09 4.39E-07 Wfdc2 NM_173109 0.09 0.03 Wfs1 NM_031823 0.17 1.18E-03 Whdc1 XM_001067296 0.15 8.25E-03 Whsc1 ENSRNOT00000050238 0.06 0.04 Whsc1l1 BC100146 -0.11 2.12E-03 Page 275 of 288 Diabetes

Whsc2 NM_001008339 0.07 9.65E-03 Wipf3 NM_147211 0.06 0.03 Wipi1 CA503947 -0.12 0.03 Wnt4 AA964952 0.3 7.41E-12 Wrb NM_199373 -0.38 0 Wrnip1 NM_172332 0.08 0.03 Wsb2 NM_001007616 0.08 1.70E-03 Wscd1 NM_001024234 -0.11 0.01 Wwp1 NM_001024757 0.13 4.91E-03 Wwp2 XM_001076615 -0.16 3.20E-04 Xkr5 NM_001012228 -0.13 0.02 Xkr6 NM_001012042 -0.4 1.38E-03 Xkr7 NM_001012092 0.08 7.84E-03 Xkr8 NM_001012099 0.29 2.83E-04 Xpa ENSRNOT00000012779 -0.43 7.33E-24 Xpnpep1 NM_131913 0.08 2.08E-03 Xpo4 BU760019 0.07 4.75E-03 Xrcc4 NM_001006999 0.06 0.03 Yars NM_001025696 0.07 7.20E-03 Yif1 NM_172017 0.13 1.30E-05 Yipf1 NM_199383 0.08 7.97E-03 Yipf3 NM_001007801 0.08 0.02 Yipf5 NM_001014150 0.09 3.70E-06 Ykt6 NM_031692 0.08 5.79E-03 Ypel4 NM_001024369 -0.25 2.09E-05 Ypel5 NM_001035221 -0.19 1.20E-03 Yrdc NM_175604 -0.23 2.88E-26 Ywhag NM_019376 -0.09 2.83E-03 Ywhah NM_013052 0.05 2.56E-03 Ywhaz NM_013011 0.07 7.17E-04 Zadh1 NM_001015009 -0.15 2.38E-11 Zbtb1 NM_001004444 -0.13 0.03 Zbtb17 NM_001012105 -0.16 1.49E-04 Zbtb20 703080592T1 -0.39 8.46E-07 Zbtb34 ENSRNOT00000051893 0.13 0.02 Zbtb39 ENSRNOT00000005685 0.09 0.02 Zbtb40 ENSRNOT00000033670 -0.11 3.72E-03 Zbtb44 NM_001034942 -0.3 1.01E-06 Zbtb8_predicted ENSRNOT00000010983 -0.05 0.04 Zc3h13 CV795564 0.1 0.01 Zc3h14 NM_138920 -0.08 1.24E-05 Zc3h15 CO382904 0.07 5.28E-03 Zc3h6 703868363J1 -0.32 7.61E-04 Zcchc11 XM_001060286 -0.21 1.37E-12 Zcchc12 NM_001014065 0.04 0.05 Zcchc17 CO406006 0.06 0.03 Zcchc3 ENSRNOT00000009859 0.07 8.48E-03 Diabetes Page 276 of 288

Zcchc8 ENSRNOT00000001668 0.05 3.95E-03 Zcrb1 BI281998 0.09 1.06E-03 Zdhhc12 NM_001013239 0.15 3.04E-06 Zdhhc13 NM_001039037 0.13 6.33E-08 Zdhhc16 NM_001039346 0.13 4.47E-05 Zdhhc3 BC128697 0.09 7.06E-03 Zdhhc4 NM_001013123 0.07 0.04 Zdhhc5 NM_001039338 0.06 0.04 Zdhhc7 NM_133394 -0.12 3.17E-08 Zfand1 ENSRNOT00000013905 0.2 2.31E-06 Zfhx3 g4999526 0.08 0.02 Zfp110 NM_001024775 0.06 0.05 Zfp148 703706961J1 0.08 0.04 Zfp169 ENSRNOT00000022932 0.13 0.03 Zfp180 NM_144757 -0.08 5.20E-03 Zfp189 ENSRNOT00000009584 -0.18 6.74E-04 Zfp207 NM_001039020 -0.09 3.42E-04 Zfp212 ENSRNOT00000009054 -0.14 5.58E-08 Zfp238 NM_022678 -0.17 9.74E-04 Zfp251 ENSRNOT00000028184 0.06 0.04 Zfp259 ENSRNOT00000025149 0.08 1.57E-03 Zfp263 ENSRNOT00000010442 0.08 3.35E-03 Zfp278 XM_223592 -0.1 6.35E-03 Zfp281 NM_001012030 0.1 0.02 Zfp330 ENSRNOT00000004614 0.06 3.69E-03 Zfp346 CK845606 0.14 0.01 Zfp364 ENSRNOT00000000110 0.04 0.02 Zfp386 NM_019620 0.07 0.03 Zfp398 ENSRNOT00000008743 0.08 5.36E-03 Zfp40 ENSRNOT00000015520 0.09 0.05 Zfp423 AW529230 -0.16 0.04 Zfp472 NM_182823 0.06 0.02 Zfp51 ENSRNOT00000029103 0.09 0.01 Zfp516 ENSRNOT00000021768 -0.11 5.58E-03 Zfp521 ENSRNOT00000022637 -0.15 6.93E-05 Zfp53 ENSRNOT00000015343 0.15 1.17E-05 Zfp593 ENSRNOT00000021937 0.15 1.82E-06 Zfp622 NM_001009652 0.12 6.43E-04 Zfp644 ENSRNOT00000002882 -0.22 5.41E-04 Zfp653 ENSRNOT00000018874 -0.09 0.04 Zfp655 NM_001008362 0.06 0.02 Zfp667 NM_001008557 0.09 1.98E-03 Zfp672 NM_001007669 0.07 0.02 Zfp706 ENSRNOT00000010801 -0.04 0.01 Zfp709 NM_153731 0.15 3.66E-06 Zfp746 BC087150 -0.08 3.38E-03 Zfyve1 ENSRNOT00000011662 -0.07 0.04 Page 277 of 288 Diabetes

Zfyve20 704295522J1 -0.08 0.01 Zfyve26 ENSRNOT00000016380 0.12 6.05E-03 Zfyve9 CB585554 0.12 0.02 Zhx1 NM_133620 -0.47 5.17E-16 Zkscan3 NM_001012053 0.06 0.03 Zmat3 NM_022548 -0.1 2.39E-03 Zmym2 ENSRNOT00000011684 -0.1 9.55E-04 Zmym6 ENSRNOT00000038888 0.17 5.68E-12 Znf291 BI296732 -0.07 2.96E-03 Znf512b CB809555 -0.12 1.94E-03 Znf532 ENSRNOT00000023048 -0.13 0.02 Znhit2 ENSRNOT00000028482 0.1 0.02 Znhit3 ENSRNOT00000039481 0.06 0.03 Znrf1 ENSRNOT00000051594 -0.5 1.47E-10 Zp1 ENSRNOT00000028396 0.08 0.03 Zrsr1 NM_001017504 0.12 3.93E-03 Zrsr2 BQ208778 0.09 0.03 Zscan20 AI410832 0.12 3.09E-03 Zswim1_predicted XM_230846 0.07 7.89E-03 Zswim3 ENSRNOT00000021052 -0.15 2.74E-05 Zswim6 XM_001073593 -0.19 3.25E-05 Zufsp NM_001008308 0.05 0.03 Zw10 NM_001024801 0.07 0.01 Zzef1 AW251798 0.13 4.14E-03 ENSRNOT00000049857 -0.58 0 Diabetes Page 278 of 288

mRNAs colored red contain seed region against both miRNA-132 and 212 Page 279 of 288 Diabetes

(pmol/μg total protein) Conditions siCACT rep1 siCACT rep2 siCACT rep3 Acyl-carnitines 1.57369944 1.33849174 1.02433187 C2 0.31212722 0.2798444 0.17309236 C3 0.02856521 0.0233578 0.01874457 C4 0.02795559 0.01949478 0.01638512 C5:1 0.02743306 0.01446387 0.01396012 C5 0.01959504 0.01015166 0.01107634 C4-OH 0.07541913 0.04069647 0.02615064 C6 0.00370057 0.00444697 0.00197396 C5-OH 0.00465998 0.00444697 0.0034659 C3-DC 0.03318093 0.02793952 0.02457767 C4-DC 0.00269976 0.00188659 0.0006554 C8:1 0.01341172 0.00898377 0.00484999 C8 0.00226432 0.00224594 0.00111419 C5-DC 0.00296103 0.00269513 0.00170405 C8:1-OH/C6:1-DC 0.00182887 0.00170692 0.00150743 C8-OH/C6-DC 0.00069671 0.00080854 0.00058986 C10:3 0.00121925 0.00116789 C10:2 0.00174178 0.00278497 0.00163851 C10:1 0.01245374 0.00655815 0.00511216 C10 0.0007838 0.00197643 C7-DC 0.00060962 0.00044919 0.00137635 C8:1-DC 0.00121925 0.00107805 0.00052432 C8-DC 0.01985631 0.01329598 0.00884796 C12:1 0.07306773 0.06082012 0.05413642 C12 0.00121925 0.00098821 0.00045878 C12-OH/C10-DC 0.00470281 0.00395286 0.00262162 C14:2 0.07855434 0.06630022 0.0539398 C14:1 0.09231441 0.09621617 0.08775868 C14 0.01454387 0.01140939 0.01022431 C14:1-OH 0.0040061 0.00323416 0.00262162 C14-OH/C12-DC 0.00539952 0.0054801 0.00367027 C16:2 0.12148925 0.10978166 0.08880733 C16:1 0.30550845 0.295566 0.25003686 C16 0.0111474 0.01131955 0.01061755 C16:1-OH/C14:1-DC 0.00696713 0.00565977 0.00576756 C16-OH 0.02107555 0.01850656 0.01415674 C18:2 0.38684963 0.3353641 0.27526994 C18:1 0.08848249 0.08049457 0.07288099 C18 0.00383192 0.00287481 0.0034081 C18:2-OH 0.00888308 0.00799555 0.00707837 C18:1-OH/C16:1-DC 0.01062487 0.00934312 0.00629188 C18-OH/C16-DC 0.0040061 0.00296464 0.00203175 C20:4 0.01332463 0.01284679 0.01179728 C20 0.00209014 0.00233578 0.00203175 C18:1-DC 0.0047899 0.00422237 0.00235946 C18-DC/C20-OH 0.00975398 0.00844474 0.00557094 Diabetes Page 280 of 288

C22 Page 281 of 288 Diabetes

siCACT+PC50 rep1 siCACT+PC50 rep2 siCACT+PC50 rep3 Scr rep 1 Scr rep2 Scr rep3 6.369218888 6.670565539 6.248673978 1.326201 1.273967 1.420543 0.570277366 0.599301759 0.506569026 0.259611 0.256048 0.272969 0.164831324 0.135096136 0.136048873 0.018671 0.021178 0.021112 0.021944999 0.030698969 0.023648185 0.022612 0.024664 0.021855 0.074612996 0.095507904 0.075061447 0.011165 0.01133 0.011352 0.034624331 0.035660419 0.0326479 0.012197 0.010371 0.011988 0.744569422 0.745767884 0.656979144 0.064832 0.052116 0.055061 0.007379196 0.010396241 0.011442577 0.002519 0.002438 0.004193 0.00627547 0.007899104 0.010769484 0.00433 0.00436 0.005567 0.047108597 0.051268312 0.041073164 0.025708 0.043575 0.034904 0.007997733 0.007855628 0.005648757 0.002346 0.002004 0.00191 0.208721321 0.188224992 0.164675623 0.016982 0.011504 0.012625 0.006534733 0.006511903 0.003829666 0.002252 0.002789 0.003289 0.008582933 0.007648901 0.006127465 0.002721 0.004445 0.004986 0.008777999 0.011576716 0.007180623 0.001314 0.002876 0.003395 0.001963907 0.001053158 0.001032 0.00122 0.000849 0.0020482 0.002489283 0.00122 0.002266 0.001061 0.0076076 0.008992627 0.005744498 0.002533 0.00183 0.002122 0.138107192 0.147913214 0.122645043 0.007787 0.010284 0.010185 0.003901333 0.005788358 0.003446699 0.001314 0.002004 0.001379 0.009655799 0.007442174 0.007850815 0.00122 0.00305 0.002016 0.004291466 0.010646444 0.006318948 0.000751 0.000959 0.001167 0.11196826 0.111942705 0.083678195 0.016607 0.016123 0.016444 0.863267482 0.922519523 0.770241506 0.050008 0.052639 0.055061 0.004486533 0.006305175 0.003255216 0.000469 0.000349 0.000637 0.011996599 0.011369989 0.008521006 0.003096 0.003225 0.004562 0.268314184 0.255411288 0.222024867 0.049164 0.055602 0.060789 0.690243359 0.663077058 0.604895691 0.047944 0.051942 0.055697 0.030332865 0.028011517 0.026137468 0.00638 0.006972 0.006471 0.013557133 0.011163261 0.013116605 0.002815 0.002702 0.003819 0.015605332 0.01230026 0.011776222 0.002252 0.003573 0.003501 0.422026708 0.308023325 0.269129754 0.074871 0.069285 0.073202 23.0301545 22.4195501 19.97161069 0.171322 0.176741 0.218439 0.04808393 0.041345413 0.038679623 0.007131 0.005403 0.006684 0.062616396 0.050544767 0.049881395 0.005348 0.006449 0.005304 0.032088465 0.028838425 0.028243784 0.012666 0.012811 0.010609 0.518097036 0.463378714 0.440794518 0.21298 0.202277 0.217166 0.154980457 0.155768843 0.141601888 0.051603 0.051593 0.055697 0.005852 0.00671863 0.006127465 0.002721 0.002179 0.002228 0.014239866 0.016021347 0.015414404 0.004691 0.006972 0.007532 0.013166999 0.012610351 0.012542155 0.00516 0.006188 0.008169 0.005169266 0.004754722 0.003925407 0.002533 0.002963 0.002546 0.016580666 0.022636614 0.017999429 0.007506 0.010197 0.010397 0.003121066 0.002377361 0.002489283 0.002815 0.001743 0.002652 0.0052668 0.005374904 0.004404116 0.003941 0.003399 0.004668 0.007705133 0.011680079 0.009765647 0.005817 0.008279 0.008805 Diabetes Page 282 of 288 Page 283 of 288 Diabetes

Scr+PC50 rep1 Scr+PC50 rep2 Scr+PC50 rep3 3.374813106 3.95255754 4.480172617 0.459097305 0.405322407 0.48023473 0.073305679 0.101347629 0.118883382 0.015047571 0.013417663 0.016596662 0.014696266 0.018866461 0.027352438 0.024942667 0.028401856 0.038535596 0.524322965 0.637781721 0.829619385 0.006304673 0.008428608 0.009535019 0.005991008 0.008054003 0.009056091 0.026816295 0.025949897 0.038464366 0.004332764 0.005244467 0.007764103 0.145147586 0.171228454 0.218748273 0.002342034 0.003677938 0.004416279 0.004449865 0.004903918 0.007336722 0.005386679 0.005925567 0.008120255 0.000569842 0.001639424 0.001634639 0.001780758 0.00409856 0.004563368 0.007407952 0.064815804 0.070766255 0.090961102 0.001229568 0.001498419 0.002136909 0.003864357 0.003201168 0.00462997 0.003278848 0.003882268 0.004843661 0.085074402 0.094945292 0.121946286 0.362546934 0.384616977 0.504096882 0.001522322 0.001634639 0.00227937 0.006323493 0.007900756 0.008120255 0.129397404 0.166937526 0.20884726 0.197257852 0.224762887 0.276872203 0.009133934 0.012191684 0.014388522 0.004859722 0.006674777 0.008120255 0.005503781 0.005721237 0.007123031 0.127055369 0.153996633 0.167604912 13.77315335 14.37140713 16.92617292 0.020492802 0.022408179 0.026925056 0.021019759 0.01982 0.026212753 0.015457427 0.017299931 0.018947262 0.19163697 0.222242819 0.252155287 0.05503781 0.056258832 0.070161852 0.002342034 0.002315739 0.002920443 0.005796535 0.006470447 0.008191485 0.006264942 0.004699588 0.007692873 0.00204928 0.001975189 0.002991673 0.007026103 0.006742887 0.008120255 0.001053916 0.001362199 0.001923218 0.002107831 0.001702749 0.002849212 0.003337399 0.004359038 0.004416279 Diabetes Page 284 of 288

Conditions siCACT rep1 siCACT rep2 siCACT rep3 Acyl-carnitines 0.065359127 0.053410738 0.054564869 C2 0.024253319 0.027881625 0.021992558 C3 0.003209998 0.001655471 0.002998985 C4 0.023094153 0.024309292 0.029240105 C5:1 0.004814997 0.002439642 0.001666103 C5 0.005884996 0.001742602 0.002499154 C4-OH 0.002407499 0.004530764 0.004248562 C6 0.000940862 0.000739337 0.001028599 C5-OH 0.000664138 0.000916135 0.000887419 C3-DC 0.005171664 0.003920854 0.00599797 C4-DC 0.000891666 0.001655471 0.001166272 C8:1 0.001426666 0.002091122 0.001999323 C8 0.002764165 0.003310943 0.004248562 C5-DC 0.003923331 0.005314935 0.003582121 C8:1-OH/C6:1-DC 0.001069999 0.002352512 0.001999323 C8-OH/C6-DC 0.000624166 0.001481211 0.000416526 C10:3 0.000624166 0.00052278 0.000416526 C10:2 0.002875293 0.002249239 C10:1 0.002764165 0.002178252 0.001249577 C10 0.002091122 0.001166272 C7-DC 0.001248333 0.001481211 0.000833051 C8:1-DC 0.000713333 0.001655471 0.000583136 C8-DC 0.002050832 0.001829732 0.002332544 C12:1 0.002407499 0.002526772 0.000833051 C12 0.0002675 0.001394081 0.00016661 C12-OH/C10-DC 0.000445833 0.00026139 0.000333221 C14:2 0.002318332 0.002265382 0.002415849 C14:1 0.008024995 0.009410049 0.006581106 C14 0.001783332 0.002439642 0.001416187 C14:1-OH 0.000356666 0.000609911 0.000583136 C14-OH/C12-DC 0.0002675 0.00034852 0.000583136 C16:2 0.01631749 0.015857674 0.016327808 C16:1 0.080249952 0.074060567 0.069143269 C16 0.001337499 0.001481211 0.001666103 C16:1-OH/C14:1-DC 0.001069999 0.000958431 0.000916357 C16-OH 0.002139999 0.002352512 0.002332544 C18:2 0.084529949 0.074060567 0.064394875 C18:1 0.015069158 0.019342877 0.013412128 C18 0.002942498 0.002439642 0.000916357 C18:2-OH 0.001604999 0.001132691 0.000249915 C18:1-OH/C16:1-DC 0.0002675 0.000697041 0.001249577 C18-OH/C16-DC 0.0008025 0.000697041 0.000249915 C20:4 0.001159166 0.001481211 0.000916357 C20 0.000356666 0.000871301 0.000583136 C18:1-DC 0.0008025 0.000784171 0.001082967 C18-DC/C20-OH 0.0008025 0.001568341 0.001416187 Page 285 of 288 Diabetes

C22 Diabetes Page 286 of 288

siCACT+PC50 rep1 siCACT+PC50 rep2 siCACT+PC50 rep3 Scr rep 1 Scr rep2 Scr rep3 3.284653337 3.007922803 3.312026908 0.081875 0.079346 0.054297 0.303503602 0.278525819 0.284921514 0.026166 0.03837 0.022234 0.098467975 0.089721202 0.083634417 0.001688 0.002157 0.001892 0.014659746 0.014823503 0.024139596 0.021102 0.019679 0.014139 0.019077752 0.016617927 0.023174013 0.003039 0.001438 0.001104 0.014726686 0.016383872 0.019311677 0.001266 0.002516 0.001997 0.453314158 0.447357715 0.451893246 0.002195 0.002336 0.00247 0.007561462 0.003637145 0.004904052 0.002026 0.001258 0.001076 0.004086007 0.003228477 0.003563376 0.002026 0.001258 0.000396 0.017672023 0.015603687 0.020425812 0.005149 0.006021 0.002944 0.005288219 0.00397894 0.004679368 0.00211 0.000788 0.11841594 0.115545305 0.105842846 0.001182 0.001078 0.001104 0.003681671 0.003354793 0.003193854 0.002532 0.002516 0.001104 0.004886582 0.004603088 0.004530817 0.004136 0.002876 0.001735 0.004886582 0.006085438 0.005793503 0.001857 0.000809 0.000578 0.000669395 0.000234055 0.000594205 0.000591 0.001887 0.000315 0.000803274 0.00101424 0.00051993 0.000844 0.000449 0.000736 0.005756795 0.005383272 0.006981914 0.003798 0.001977 0.001735 0.081532286 0.081763322 0.068407903 0.001013 0.001617 0.001419 0.001941245 0.001326313 0.000817032 0.001435 0.000629 0.000788 0.004685764 0.004447051 0.007130465 0.000928 0.001977 0.000841 0.002945337 0.002886682 0.002822476 0.001182 0.000539 0.000946 0.053350765 0.053832721 0.051398772 0.001351 0.001168 0.002103 0.480558526 0.436513153 0.416315194 0.002026 0.002696 0.001524 0.001071032 0.002808664 0.003565233 0.000506 0.000359 0.000368 0.00381555 0.004915162 0.005719227 0.000506 0.00027 0.000158 0.107170107 0.117339729 0.110373663 0.00211 0.002336 0.001051 0.373856995 0.413419695 0.389130295 0.006246 0.007368 0.003206 0.015262201 0.018178296 0.018643196 0.002195 0.002516 0.000946 0.006292311 0.005773364 0.007798947 0.001013 0.000988 0.000736 0.01024174 0.00998636 0.015226515 0.000506 0.000988 0.000473 0.262268882 0.27048992 0.330823885 0.020933 0.01941 0.009198 16.0560367 15.87729797 16.93143867 0.097828 0.11511 0.063601 0.026307216 0.034250094 0.039886041 0.002532 0.001438 0.001051 0.027579066 0.034718204 0.039960317 0.000675 0.000629 0.000526 0.016333233 0.017008019 0.018494645 0.003123 0.003594 0.001262 0.298884778 0.279149966 0.303119056 0.071493 0.082671 0.034323 0.07852001 0.08184134 0.085788412 0.014096 0.013569 0.006202 0.002275942 0.003822903 0.002599649 0.001182 0.001887 0.000263 0.006158432 0.007021659 0.007427568 0.000928 0.000449 0.000263 0.005288219 0.004759125 0.006759087 0.001097 0.000629 0.000263 0.00133879 0.001872442 0.001336962 0.000338 0.000719 0.000263 0.007631101 0.008660046 0.009655839 0.001773 0.001707 0.000946 0.000870213 0.002262535 0.0027482 0.000422 0.000539 0.000421 0.003079216 0.002964701 0.004010887 0.000338 0.000629 0.000315 0.003213095 0.005305254 0.004159438 0.000591 0.001438 0.000473 Page 287 of 288 Diabetes Diabetes Page 288 of 288

Scr+PC50 rep1 Scr+PC50 rep2 Scr+PC50 rep3 3.365469175 3.489047731 3.770153026 0.537557841 0.523925994 0.567017352 0.083233069 0.071054344 0.069264168 0.0311577 0.022553767 0.027610785 0.020217496 0.017364404 0.018691837 0.014353547 0.018062972 0.023056428 0.459488549 0.547777101 0.596430903 0.009463526 0.004565227 0.009876023 0.003489675 0.004615952 0.006348872 0.033608305 0.020557858 0.024764312 0.004551125 0.005788135 0.00550318 0.137584 0.162167569 0.124770385 0.006826687 0.003293249 0.003036237 0.008839684 0.006187316 0.006167357 0.004988733 0.005987726 0.004079944 0.001225303 0.000898159 0.001138589 0.000962738 0.000997954 0.006826687 0.005189362 0.005408298 0.064065832 0.074447389 0.056644806 0.002100519 0.003592635 0.001802766 0.007614382 0.007085475 0.005408298 0.002888214 0.003892022 0.002372061 0.059952315 0.091711998 0.068789756 0.297398493 0.354074176 0.264437309 0.00105026 0.001995909 0.002466943 0.003938473 0.004889976 0.004649239 0.082095287 0.108278039 0.091941067 0.221254676 0.221246462 0.235972583 0.011902941 0.012773815 0.011955185 0.003850952 0.005488749 0.005218533 0.009102249 0.009680156 0.008729183 0.248473903 0.246694296 0.263108955 21.95803877 23.22898244 22.78933446 0.029494789 0.030138219 0.0329242 0.024155969 0.024150493 0.026092666 0.01452859 0.015468291 0.013283539 0.207601302 0.229130301 0.209785034 0.056363929 0.059178688 0.06034522 0.002888214 0.00349284 0.003226002 0.004025995 0.004091613 0.005408298 0.004463603 0.006187316 0.005787828 0.001750433 0.002694477 0.002182296 0.006038992 0.007085475 0.007495711 0.001925476 0.000997954 0.001613001 0.002888214 0.002694477 0.001992531 0.0032383 0.004490794 0.003036237