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Supplementary Table S1. Prioritization of Candidate FPC Susceptibility Genes by Private Heterozygous Ptvs

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Supplementary Table S1. Prioritization of Candidate FPC Susceptibility Genes by Private Heterozygous Ptvs Supplementary Table S1. Prioritization of candidate FPC susceptibility genes by private heterozygous PTVs Number of private Number of private Number FPC patient heterozygous PTVs in heterozygous PTVs in tumors with somatic FPC susceptibility Hereditary cancer Hereditary Gene FPC kindred BCCS samples mutation DNA repair gene Cancer driver gene gene gene pancreatitis gene ATM 19 1 - Yes Yes Yes Yes - SSPO 12 8 1 - - - - - DNAH14 10 3 - - - - - - CD36 9 3 - - - - - - TET2 9 1 - - Yes - - - MUC16 8 14 - - - - - - DNHD1 7 4 1 - - - - - DNMT3A 7 1 - - Yes - - - PKHD1L1 7 9 - - - - - - DNAH3 6 5 - - - - - - MYH7B 6 1 - - - - - - PKD1L2 6 6 - - - - - - POLN 6 2 - Yes - - - - POLQ 6 7 - Yes - - - - RP1L1 6 6 - - - - - - TTN 6 5 4 - - - - - WDR87 6 7 - - - - - - ABCA13 5 3 1 - - - - - ASXL1 5 1 - - Yes - - - BBS10 5 0 - - - - - - BRCA2 5 6 1 Yes Yes Yes Yes - CENPJ 5 1 - - - - - - CEP290 5 5 - - - - - - CYP3A5 5 2 - - - - - - DNAH12 5 6 - - - - - - DNAH6 5 1 1 - - - - - EPPK1 5 4 - - - - - - ESYT3 5 1 - - - - - - FRAS1 5 4 - - - - - - HGC6.3 5 0 - - - - - - IGFN1 5 5 - - - - - - KCP 5 4 - - - - - - LRRC43 5 0 - - - - - - MCTP2 5 1 - - - - - - MPO 5 1 - - - - - - MUC4 5 5 - - - - - - OBSCN 5 8 2 - - - - - PALB2 5 0 - Yes - Yes Yes - SLCO1B3 5 2 - - - - - - SYT15 5 3 - - - - - - XIRP2 5 3 1 - - - - - ZNF266 5 2 - - - - - - ZNF530 5 1 - - - - - - ACACB 4 1 1 - - - - - ALS2CL 4 2 - - - - - - AMER3 4 0 2 - - - - - ANKRD35 4 4 - - - - - - ATP10B 4 1 - - - - - - ATP8B3 4 6 - - - - - - C10orf95 4 0 - - - - - - C2orf88 4 0 - - - - - - C5orf42 4 2 - - - - - - CACNA2D4 4 2 - - - - - - CAPN14 4 0 - - - - - - CCDC141 4 1 - - - - - - CCDC142 4 0 - - - - - - CCDC173 4 3 - - - - - - CCDC180 4 4 - - - - - - CDH26 4 1 - - - - - - CDKN2A 4 0 5 Yes Yes Yes Yes - CEP89 4 2 - - - - - - CFTR 4 5 - - - - - - CLTCL1 4 1 - - - - - - COL6A5 4 3 - - - - - - CROT 4 2 - - - - - - DHX58 4 3 - - - - - - DNAH10 4 4 1 - - - - - DNAH8 4 5 - - - - - - DNAH9 4 2 1 - - - - - DOK7 4 0 - - - - - - EFCAB13 4 0 1 - - - - - FAM151A 4 3 - - - - - - FAM186A 4 3 - - - - - - FANCG 4 1 - Yes - - Yes - FETUB 4 0 - - - - - - FPGT-TNNI3K 4 1 - - - - - - GPR155 4 0 - - - - - - HARS2 4 0 - - - - - - IQGAP2 4 2 - - - - - - KIF6 4 1 - - - - - - LOC440335 4 0 - - - - - - MYH1 4 2 - - - - - - MYO7B 4 2 3 - - - - - MYOF 4 2 - - - - - - MYOM2 4 3 - - - - - - NLRX1 4 0 - - - - - - PCDHAC1 4 2 - - - - - - PKDREJ 4 3 - - - - - - PTPN22 4 0 - - - - - - RANBP17 4 3 - - - - - - RYR1 4 5 4 - - - - - SLC4A11 4 1 - - - - - - SPAG4 4 0 - - - - - - SPATA31E1 4 4 - - - - - - SPG7 4 1 - - - - - - SPINK5 4 0 - - - - - - TEX15 4 7 - - - - - - TRIM47 4 1 - - - - - - TTLL6 4 2 - - - - - - USH2A 4 6 1 - - - - - USP45 4 5 - - - - - - ZBBX 4 1 1 - - - - - ZDBF2 4 1 - - - - - - ZFR2 4 1 - - - - - - ZNF142 4 0 - - - - - - AARS2 3 1 - - - - - - ABCA10 3 2 1 - - - - - ABCA12 3 0 - - - - - - ABCA4 3 0 - - - - - - ABCA7 3 4 - - - - - - ABCB5 3 3 - - - - - - ABCC11 3 0 1 - - - - - ABCC2 3 1 - - - - - - ACBD4 3 2 - - - - - - ADAM2 3 0 - - - - - - ADAMTSL4 3 1 - - - - - - ADCY10 3 3 - - - - - - ALS2CR11 3 1 - - - - - - ANKMY1 3 2 - - - - - - APOBR 3 1 - - - - - - ARHGAP10 3 1 - - - - - - ARHGEF40 3 2 - - - - - - ASB18 3 0 - - - - - - ASPSCR1 3 2 - - - - - - ATP13A5 3 0 - - - - - - ATP1A4 3 5 - - - - - - BANK1 3 1 - - - - - - BBS12 3 2 1 - - - - - BTBD11 3 0 - - - - - - BUB1B 3 0 1 Yes - - Yes - C16orf89 3 0 - - - - - - HEATR9 3 0 - - - - - - C17orf80 3 2 - - - - - - TBC1D32 3 4 - - - - - - C8A 3 2 - - - - - - C9orf131 3 1 - - - - - - C9orf84 3 0 - - - - - - CAPS2 3 2 - - - - - - CARD14 3 3 - - - - - - CARNS1 3 0 - - - - - - CATSPER3 3 0 - - - - - - CBX2 3 2 - - - - - - CCDC129 3 1 - - - - - - CCDC40 3 0 1 - - - - - CD101 3 2 - - - - - - CEP250 3 1 - - - - - - CHRNE 3 1 - - - - - - CIDEB 3 1 - - - - - - CLCA1 3 1 1 - - - - - CLCNKA 3 2 - - - - - - CLIC3 3 1 - - - - - - CLIP1 3 0 - - - - - - COL6A6 3 3 - - - - - - CPZ 3 1 - - - - - - CREB3L3 3 1 - - - - - - CSRP2BP 3 0 - - - - - - DENND4A 3 0 - - - - - - DNAH11 3 3 1 - - - - - DNAH17 3 3 - - - - - - DNAH7 3 4 3 - - - - - DNAJC28 3 1 - - - - - - DUOX1 3 1 - - - - - - DUSP27 3 2 - - - - - - ECT2L 3 0 - - - - - - EFCAB6 3 6 - - - - - - ADGRE2 3 5 - - - - - - EPX 3 3 - - - - - - ERAP2 3 2 - - - - - - ERVV-2 3 0 - - - - - - ESCO2 3 1 - Yes - - - - EYS 3 5 1 - - - - - FAM161A 3 1 - - - - - - FAM185A 3 0 - - - - - - FANCC 3 0 - Yes - - Yes - FANCM 3 3 2 Yes - - Yes - FCRL6 3 2 - - - - - - FER1L6 3 1 - - - - - - GALK2 3 0 - - - - - - GJB2 3 3 - - - - - - GP1BA 3 1 - - - - - - GPBAR1 3 0 - - - - - - HEATR6 3 3 - - - - - - HEMGN 3 1 - - - - - - HGFAC 3 1 - - - - - - IFNAR2 3 0 - - - - - - IGSF10 3 6 1 - - - - - IL12RB2 3 1 - - - - - - IQCE 3 1 1 - - - - - KIAA0141 3 1 - - - - - - KIAA1217 3 1 - - - - - - KIAA1683 3 4 - - - - - - LAMB4 3 4 - - - - - - LARS 3 2 - - - - - - LEKR1 3 0 - - - - - - LIME1 3 0 - - - - - - LOC402160 3 0 - - - - - - LRP1B 3 3 3 - - - - - LRRC26 3 0 - - - - - - LRRIQ1 3 6 1 - - - - - LTBP1 3 0 1 - - - - - LY75-CD302 3 1 - - - - - - LZTR1 3 1 - - - - - - MAMDC4 3 4 - - - - - - MAN2A2 3 0 - - - - - - MAN2C1 3 2 - - - - - - MFI2 3 1 - - - - - - MMP9 3 1 - - - - - - MNS1 3 1 - - - - - - MSH4 3 1 - Yes - - - - MTERF3 3 0 - - - - - - MYH4 3 7 - - - - - - MYO1H 3 0 - - - - - - MYO3B 3 1 - - - - - - MYO5B 3 0 - - - - - - MYOM3 3 2 - - - - - - NBEAL1 3 1 - - - - - - NEK1 3 1 - - - - - - NEK3 3 1 - - - - - - NLRP6 3 1 - - - - - - NLRP8 3 0 - - - - - - NPL 3 0 1 - - - - - NRAP 3 2 2 - - - - - NUDT8 3 1 - - - - - - NUP85 3 0 - - - - - - OR2T2 3 0 1 - - - - - P2RX6 3 0 - - - - - - PALLD 3 1 - - - - - - PCDH15 3 3 3 - - - - - PCDHGA9 3 0 - - - - - - PCDHGB5 3 0 - - - - - - PDE4C 3 0 - - - - - - PDE4DIP 3 3 - - - - - - PHYHD1 3 2 - - - - - - PKHD1 3 5 1 - - - - - PLB1 3 4 - - - - - - PPL 3 0 - - - - - - PRR5-ARHGAP8 3 2 - - - - - - RAD54L 3 0 1 Yes - - - - RGS22 3 1 - - - - - - RNF213 3 4 - - - - - - SACS 3 2 2 - - - - - SAMD11 3 0 - - - - - - SCN10A 3 1 - - - - - - SCNN1D 3 3 - - - - - - SEMA3B 3 1 - - - - - - SFI1 3 6 - - - - - - SLC12A3 3 3 - - - - - - SLC14A1 3 0 - - - - - - SLC15A5 3 0 - - - - - - SLC26A10 3 0 - - - - - - SLC4A9 3 1 - - - - - - SLCO1B1 3 2 - - - - - - SMC2 3 1 - - - - - - STARD9 3 6 - - - - - - SYCE1L 3 0 - - - - - - TDRD6 3 2 - - - - - - TG 3 2 - - - - - - THUMPD3 3 1 - - - - - - TJAP1 3 0 - - - - - - TMEM63A 3 3 - - - - - - TNFRSF10B 3 1 - - - - - - TNN 3 3 - - - - - - TONSL 3 0 - - - - - - TREM1 3 0 - - - - - - TRIM6-TRIM34 3 3 - - - - - - TRPM2 3 4 - - - - - - TRPM4 3 1 - - - - - - TYRP1 3 0 1 - - - - - UBA7 3 0 - - - - - - ULK4 3 0 - - - - - - USP4 3 0 - - - - - - VWA8 3 5 - - - - - - WDR41 3 0 - - - - - - ZCCHC4 3 3 - - - - - - ZMYM2 3 0 - - - - - - ZNF133 3 0 - - - - - - ZNF175 3 2 - - - - - - ZNF211 3 0 - - - - - - ZNF227 3 0 - - - - - - ZNF229 3 0 - - - - - - ZNF30 3 0 - - - - - - ZNF554 3 1 - - - - - - ZNF573 3 0 - - - - - - ZNF620 3 1 - - - - - - ZNF74 3 2 - - - - - - MARCH10 2 1 - - - - - - SEPT8 2 0 - - - - - - A2ML1 2 2 - - - - - - AAR2 2 1 - - - - - - ABCA5 2 0 - - - - - - ABCA8 2 3 1 - - - - - ABCA9 2 4 - - - - - - ABCB10 2 0 - - - - - - ABCC4 2 0 1 - - - - - ABCC9 2 4 - - - - - - ABL2 2 1 - - - - - - ACAT1 2 0 - - - - - - ACCSL 2 0 - - - - - - ACOX3 2 2 - - - - - - ACOXL 2 2 - - - - - - ACSM1 2 1 - - - - - - ACSM2B 2 1 - - - - - - ACTR5 2 0 - - - - - - ADAM15 2 2 - - - - - - ADAM29 2 2 1 - - - - - ADAM33 2 0 - - - - - - ADAMTS12 2 3 - - - - - - ADCK2 2 1 - - - - - - ADRB1 2 0 - - - - - - AFP 2 0 - - - - - - AGAP3 2 1 - - - - - - AGBL1 2 3 - - - - - - AGMO 2 3 - - - - - - AGR3 2 2 - - - - - - AIFM3 2 1 - - - - - - AIRE 2 1 - - - - - - AKAP12 2 0 - - - - - - AKR1D1 2 3 - - - - - - ALDH16A1 2 2 - - - - - - ALDH3A1 2 1 - - - - - - ALDH3B1 2 0 1 - - - - - ALG13 2 0 - - - - - - ALLC 2 0 - - - - - - ALMS1 2 4 - - - - - - ALOX5AP 2 0 - - - - - - ALPK2 2 4 - - - - - - ALPK3 2 1 1 - - - - - ALS2CR12 2 2 - - - - - - CARF 2 0 - - - - - - AMHR2 2 1 - - - - - - AMICA1 2 2 - - - - - - AMPD3 2 1 - - - - - - ANGPTL4 2 2 - - - - - - ANGPTL5 2 3 - - - - - - ANKK1 2 3 - - - - - - ANKRD13D 2 0 - - - - - - ANKRD42 2 1 - - - - - - ANKZF1 2 2 - - - - - - ANO7 2 2 1 - - - - - ANXA5 2 0 - - - - - - AOX1 2 6 - - - - - - AP1G2 2 1 - - - - - - APOL5 2 2 - - - - - - APPL2 2 3 - - - - - - LVRN 2 2 - - - - - - ARHGAP11A 2 0 - - - - - - ARHGAP25 2 0 - - - - - - ARHGAP9 2 0 - - - - - - ARHGEF1 2 0 1 - - - - - ARHGEF10 2 2 - - - - - - ARHGEF37 2 2 - - - - - - ARL10 2 0 - - - - - - ARSA 2 1 - - - - - - ASB11 2 0 - - - - - - ASB13 2 0 - - - - - - ASPG 2 2 - - - - - - ASPM 2 1 - - - - - - ASTE1 2 2 - Yes - - - - ASXL3 2 0 - - - - - - ATF7IP2 2 0 - - - - - - ATG2B 2 1 - - - - - - ATG9B 2 1 - - - - - - ATP2C2 2 3 - - - - - - ATP6V0A4 2 0 - - - - - - ATR 2 5 - Yes - - - - B3GNTL1 2 1 - - - - - - BBS4 2 0 - - - - - - BEST3 2 2 - - - - - - BIRC6 2 1 1 - - - - - BLVRB 2 0 - - - - - - BNIPL 2 1 - - - - - - BRCA1 2 2 - Yes Yes Yes Yes - BRICD5 2 2 - - - - - - BRIP1 2 4 - Yes - - Yes - BSG 2 0 - - - - - - BTN2A2 2 2 - - - - - - C11orf16 2 1 - - - - - - C11orf40 2 2 - - - - - - C11orf42 2 1 - - - - - - C11orf49 2 1 - - - - - - RITA1 2 1 - - - - - - C14orf159 2 3 - - - - - - C16orf13 2 0 - - - - - - C16orf58 2 1 - - - - - - C1orf100 2 0 1 - - - - - C1orf101 2 2 - - - - - - C1orf112 2 1 - - - - - - C1orf116 2 0 - - - - - - C1orf177 2 2 - - - - - - C1orf204 2 0 - - - - - - C1QTNF7 2 0 - - - - - - C21orf58 2 1 - - - - - - C22orf23 2 1 - - - - - - PRR34 2 0 - - - - - - C22orf29 2.
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