US 201701 35347A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0135347 A1 KAGAMI (43) Pub. Date: May 18, 2017

(54) INSECTICIDAL, MITICIDAL, AOIN 37/34 (2006.01) NEMATICIDAL MOLLUSCICIDAL, AOIN 37/08 (2006.01) MICROBICIDAL, OR BACTERICIDAL AOIN 43/22 (2006.01) COMPOSITION AND METHOD FOR AOIN 47/30 (2006.01) CONTROLLING PEST AOIN 47/06 (2006.01) AOIN 43/56 (2006.01) (71) Applicant: NISSAN CHEMICAL INDUSTRIES, AOIN 43/73 (2006.01) LTD., Tokyo (JP) (52) U.S. Cl. CPC ...... A0IN 43/80 (2013.01): A0IN 43/56 (72) Inventor: Takahiro KAGAMI, Shiraoka-shi (JP) (2013.01); A0IN 41/10 (2013.01); A0IN 37/34 (2013.01); A0IN 43/713 (2013.01); (73) Assignee: NISSAN CHEMICAL INDUSTRIES, A0IN 43/22 (2013.01); A0IN 47/30 LTD., Tokyo (JP) (2013.01); A0IN 47/06 (2013.01); A0IN (21) Appl. No.: 15/322,286 37/08 (2013.01) (22) PCT Filed: Jun. 30, 2015 (57) ABSTRACT The present invention provides a novel insecticidal, miti (86). PCT No.: PCT/UP2O15/0688SO cidal, nematicidal, microbicidal, or bactericidal composition S 371 (c)(1), and a novel pest control method. An insecticide, miticide, (2) Date: Dec. 27, 2016 nematicide, molluscicide, disinfectant, or bactericide com position containing one or two Substances selected from (30) Foreign Application Priority Data 4-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl) isoxazole-3-yl)-2-methyl-N-(2-oxo-2-(2.2.2-trifluoroethyl) Jun. 30, 2014 (JP) ...... 2014-134037 aminoethylbenzamide or (Z)-4-5-(3,5-dichlorophenyl)-5- trifluoromethyl-4,5-dihydroisoxazole-3-yl)-N- Publication Classification (methoxyiminomethyl)-2-methylbenzamide, and one or (51) Int. Cl. more Substances selected from known insecticide, miticide, AOIN 43/80 (2006.01) nematicide, molluscicide, disinfectant, or bactericide com AOIN 4I/It (2006.01) pounds. US 2017/O 135347 A1 May 18, 2017

INSECTICIDAL, MITICIDAL, SUMMARY OF THE INVENTION NEMATICIDAL MOLLUSCICIDAL, MICROBICIDAL, OR BACTERICIDAL Problem to be Solved by the Invention COMPOSITION AND METHOD FOR 0011 Nowadays, insecticides, miticides, and microbi CONTROLLING PEST cides are developed for controlling various pests, such as horticulture pests, forest pests, and sanitary pests, and a TECHNICAL FIELD variety of Such chemicals are prepared for actual uses. However, by using these chemicals for long years, pests 0001. The present invention relates to a pesticide char have acquired insecticide resistances, and pathogens have acterized by mixing an isoxazoline-Substituted benzamide acquired microbicide resistances. Accordingly, the cases that compound or a salt thereof and an active ingredient com are hard to be controlled by conventional chemicals have pound of known insecticides, miticides, nematicides, mol been increasing in recent years. Also, Some of Such chemi luscicides, microbicides, or bactericides. cals are highly toxic, and gradually disturbing ecosystems by remaining in environments for long years. Accordingly, BACKGROUND ART developments of novel chemicals that are low toxic and low persistent, in addition to having excellent pest control 0002 First active ingredient compounds of a composition effects, have always been expected. of the present invention, that is, 4-5-(3,5-dichlorophenyl)- 0012 Meanwhile, when taking into account the biologi 4,5-dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl cal diversities of and pathogens, and varieties of their N-2-oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide modes and situations of infliction, efficient control of all and (Z)-4-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-di pests in all situations is difficult by uses of only one type of hydroisoxazole-3-yl)-N-(methoxyiminomethyl)-2-methyl Such novel chemicals or conventional known chemicals. benzamide, have been known as isoxazoline-substituted Accordingly, novel methods, in which a plurality of insec benzamide compounds having activities as pesticides (see, ticides, miticides, nematicides, molluscicides, microbicides, for example, Patent Documents 1 and 2). or bactericides are suitably combined so that higher control 0003. Also, compounds described as active ingredient effects can be induced, have been strongly demanded in groups A to Rhaving insecticidal activities, miticidal activi order to control harmful organisms that are difficult to ties, nematicidal activities, molluscicidal activities, micro control. bicidal activities, or bactericidal activities are second active ingredient compounds of the composition of the present Means for Solving the Problem invention (hereinafter, abbreviated as “second active ingre 0013. In view of above situations, and as results of dient compounds II), and all of them are well-known (see, intensive studies to develop pesticides that show excellent for example, Non-Patent Document 1). pest control activities, and show little adverse impact to mammals, fishes, and non-target organisms such as natural 0004. In addition, compositions containing the first active enemies and beneficial insects, the present inventors found ingredient compound of the present invention, that is, 4-5- that a composition that contains an isoxazoline-substituted (3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isox benzamide compound and some known compounds having azole-3-yl)-2-methyl-N-(2-oxo-2-(2.2.2-trifluoroethyl) insecticidal, miticidal, nematicidal, molluscicidal, microbi aminoethylbenzamide or (Z)-4-5-(3,5-dichlorophenyl)-5- cidal, or bactericidal activities exhibits excellent insecti trifluoromethyl-4,5-dihydroisoxazole-3-yl)-N- cidal, miticidal, nematicidal, molluscicidal, microbicidal, or (methoxyiminomethyl)-2-methylbenzamide and known bactericidal effects synergistically, which could not be insecticides, miticides, nematicides, molluscicides, micro expected from single uses of them, whereby the present bicides, or bactericides, have also been known (see, for invention was completed. example, Patent Documents 3, 4, and 5). 0014 That is, the present invention relates to composi tions of 1 to 6 (hereinafter, referred to as compositions of PRIOR ART DOCUMENTS the present invention), and control methods of 7 to 8 (hereinafter, referred to as methods of the present invention) Patent Documents described in below. 0.015 1 0005 Patent Document 1: WO2005/085216 0016. An insecticidal, miticidal, nematicidal, mollusci cidal, microbicidal, or bactericidal composition comprising 0006 Patent Document 2: WO2007/026965 at least two types of active compounds with amounts that are 0007 Patent Document 3: Japanese Patent Application synergistically active, in which the two types of active Publication No. 2009-108046 (JP 2009-108046A) compounds include: 00.17 1) one or two active compound(s) I containing 0008 Patent Document 4: Japanese Patent Application 4-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl) Publication No. 2012-153620 (JP 2012-153620 A) isoxazole-3-yl)-2-methyl-N-(2-oxo-2-(2.2.2-trifluoroethyl) 0009 Patent Document 5: Japanese Patent Application aminoethylbenzamide or (Z)-4-5-(3,5-dichlorophenyl)-5- Publication No. 2012-153621 (JP 2012-153621 A) trifluoromethyl-4,5-dihydroisoxazole-3-yl)-N- (methoxyiminomethyl)-2-methylbenzamide; and Non-Patent Documents 0018, 2) one or more active compound(s) II selected from active ingredient groups A to R below. 0010. Non-Patent Document 1: The Pesticide Manual 0019 Active ingredient group A (inhibitors of nucleic 16th Edition, The British Crop Protection Council, 2012 acid biosyntheses): benalaxyl, benalaxyl-M, furalaxyl, US 2017/O 135347 A1 May 18, 2017 metalaxyl, metalaxyl-M, ofurace, oxadixyl, bupirimate, propineb, thiram, Ziram, captan, folpet, chlorothalonil. ethirimol, and hymexaZol. dichlofluanid, tolylfluanid, guazatline, iminoctadine-albesi 0020 Active ingredient group B (inhibitors of mitoses late, iminoctadine-triacetate, anilazine, dithianon, chinome and cell divisions): benomyl, carbendazim, fuberidazole, thionat, and fluoroimide. thiabendazole, thiophanate-methyl, diethofencarb, etha boxam, Zoxamide, pencycuron, and fluopicolide. 0030 Active ingredient group L (other chemicals): 0021 Active ingredient group C (inhibitors of respira cyflufenamid, cymoxanil, diclomeZine, dodine, ferimZone, tion): diflumetorim, benodanil, benzovindiflupyr, bixafen, flusulfamide, flutianil, fosetyl-aluminium, metrafenone, boscalid, carboxin, fenfuram, fluopyram, flutolanil, fluxapy Oxathiapiprolin, picarbutraZOX, pyriofenone, tebufloquin, roXad, furametpyr, isofetamid, isopyrazam, mepronil, oxy tolprocarb, triaZOxide, potassium hydrogen carbonate, carboxin, penflufen, penthiopyrad, sedaxane, thifluZamide, Sodium hydrogen carbonate, Chinese mushroom mycelium azoxystrobin, coumoxystrobin, dimoxystrobin, enestrobin, extract, Chinese mushroom carpophore extract, BCF-082 enoxastrobin, famoxadone, fenamidone, fenaminstrobin, (test name), NNF-0721 (test name), and ZF-9646 (test flufenoxystrobin, fluoxastrobin, kresoxim-methyl, mande name). strobin, metominostrobin, orysastrobin, picoxystrobin, pyra clostrobin, pyrametostrobin, pyraoxystrobin, pyribencarb 0031 Active ingredient group M (insecticides): abamec methyl, pyriminostrobin, triclopyricab, trifloxystrobin, tin, acephate, acetamiprid, afidopyropen, afoxolaner, alany amisulbrom, cyaZofamid, dinocap, fluaZinam, meptylidi carb, aldicarb, allethrin, azamethiphos, azinphos-ethyl, azin nocap, fentin, tributyltin oxide, silthiofam, and ametoctra phos-methyl, Bacillus thuringiensis, bendiocarb, din. benfluthrin, benfuracarb, bensultap, bifenthrin, bioallethrin, 0022 Active ingredient group D (inhibitors of amino acid bioresmethrin, bistrifluron, buprofezin, butocarboxim, car biosyntheses and protein biosyntheses): cyprodinil, mepa baryl, carbofuran, carbosulfan, cartap, chlorantraniliprole, nipyrim, pyrimethanil, blasticidin-S, and kasugamycin. chlorethoxyfos, chlorfeinapyr, chlorfenvinphos, chlorflua 0023 Active ingredient group E (chemicals affecting Zuron, chlormephos, chlorpyrifos, chlorpyrifos-methyl, signal transduction systems): produinazid, quinoxyfen, fen chromafenozide, clothianidin, cyanophos, cyantraniliprole, piclonil, fludioxonil, chloZolinate, iprodione, procymidone, cyclaniliprole, cycloprothrin, cyfluthrin, beta-cyfluthrin, and VincloZolin. cyhalothrin, gamma-cyhalothrin, lambda-cyhalothrin, 0024 Active ingredient group F (inhibitors of lipid syn cypermethrin, alpha-cypermethrin, beta-cypermethrin, Zeta theses and cell membrane syntheses): edifenphos, iproben cypermethrin, cyphenothrin, cyromazine, deltamethrin, fos, isoprothiolane, pyrazophos, biphenyl, chloroneb, diclo diafenthiuron, diazinon, dichlorvos, diflubenZuron, dime ran, etridiazole, quintoZene, tecnaZene, tolclofoS-methyl, thoate, dimethylvinphos, dinotefuran, diofenolan, disulfo propamocarb hydrochloride, and Bacillus subtilis (Strain: ton, emamectin-benzoate, empenthrin, endosulfan, alpha D747, FZB24, GBO3, HAI0404, MBI600, QST713, Y1336, endosulfan, EPN, esfenvalerate, ethiofencarb, ethiprole, and the like). etofemprox, etrimfos, fenitrothion, fenobucarb, fenoxycarb, 0025 Active ingredient group G (inhibitors of sterol fenthion, fenvalerate, fipronil, flometoquin, flonicamid, flua biosyntheses): azaconazole, bitertanol, bromuconazole, Zuron, flubendiamide, flucycloxuron, flucythrinate, flufen climbazole, cyproconazole, diclobutraZol, difenoconazole, erim, flufenoxuron, flufiprole, fluhexafon, flumethrin, diniconazole, diniconazole-M, epoxiconazole, etaconazole, flupyradifurone, fluvalinate, tau-fluvalinate, fonofos, fura fenarimol, fenbuconazole, fluotrimazole, fluguinconazole, thiocarb, halofenozide, heptafluthrin, hexaflumuron, flusilaZole, flutriafol, furconazole, hexaconazole, imazalil, hydramethylnon, imidacloprid, imiprothrin, indoxacarb, imibenconazole, ipconazole, metconazole, myclobutanil, indoxacarb-MP, isoprocarb, isoxathion, lepimectin, nuarimol, Oxpoconazole fumarate, pefurazoate, pencon lufenuron, malathion, meperfluthrin, metaflumizone, metal azole, prochloraz, propiconazole, prothioconazole, dehyde, methacrifos, methamidophos, methidathion, pyrifenox, pyrisoxazole, simeconazole, tebuconazole, tetra methomyl, methoprene, methoxychlor, methoxyfenozide, conazole, triadimefon, triadimenol, triflumizole, triforine, metofluthrin, muscalure, nitenpyram, novaluron, noviflu triticonazole, aldimorph, dodemorph-acetate, fenpropidin, muron, omethoate, oxydemeton-methyl, parathion-methyl, fenpropimorph, piperalin, spiroxamine, tridemorph, fenhex permethrin, phenothrin, phenthoate, phorate, phosalone, amid, and fenpyraZamine. phosmet, phoxim, pirimicarb, pirimiphos-methyl, profeno 0026 Active ingredient group H (inhibitors of cell wall fos, prothiofos, pymetrozine, pyraclofos, pyrethrins, pyrida syntheses): validamycin, polyoxins, polyoxin-D (polyoxo lyl, pyrifluquinazon, pyriprole, pyriproxyfen, resmethrin, rim), benthiavalicarb-isopropyl, dimethomorph, flumorph, rotenone, Silafluofen, spinetoram, spinosad, spirotetramat, iprovalicarb, mandipropamid, pyrimorph, and Valifenalate. sulfotep, sulfoxaflor, tebufenozide, teflubenzuron, tefluthrin, 0027 Active ingredient group I (inhibitors of melanin terbufos, tetrachlorvinphos, tetramethrin, d-tetramethrin, syntheses): phthalide, pyroquilon, tricyclazole, carprop tetramethylfluthrin, tetraniliprole, thiacloprid, thiame amid, diclocymet, and fenoxanil. thoxam, thiocyclam, thiodicarb, thiofanox, thiometon, 0028 Active ingredient group J (chemicals inducing host tolfenpyrad, tralomethrin, transfluthrin, triaZamate, trichlo defense): acibenzolar-S-methyl, probenazole, isotianil, tia rfon, triflumeZopyrim, triflumuron, ME5382 (test name), dinil, and laminarin. MIE-1209 (test name), and ZDI2501 (test name). 0029 Active ingredient group K (multifunctional chemi 0032) Active ingredient group N (miticides): acequino cals): bordeaux mixture, cheshunt mixture, basic copper cyl, acrinathrin, amidoflumet, amitraz, azocyclotin, benzo carbonate, copper hydroxide, copper naphthenate, copper ximate, bifenazate, bromopropylate, clofentezine, cyenopy oleate, copper oxychloride, copper Sulfate, basic copper rafen, cyflumetofen, dicofol, dienochlor, etoxazole, Sulfate, Oxine copper, calcium polysulfide, Sulfur, amobam, fenaZaquin, fenbutatin oxide, fenothiocarb, fenpropathrin, ferbam, mancoZeb, maneb, metiram, polycarbamate, fenpyroximate, fluacrypyrim, formetanate, halfenprox. US 2017/O 135347 A1 May 18, 2017 hexythiazox, milbemectin, propargite, pyflubumide, pyrida dient group M consisting of chlorantraniliprole, ben, pyrimidifen, Spirodiclofen, Spiromesifen, tebufenpyrad, cyantraniliprole, flubendiamide, and gamma-cyhalothrin. and NA-89 (test name). 0043 5 0033 Active ingredient group O (nematicides): cadusa 0044. The insecticidal, miticidal, nematicidal, microbi fos, dichlofenthion, ethoprophos, fenamiphos, fluenSulfone, cidal, or bactericidal composition according to any one of fosthiazate, fosthietan, imicyafos, isamidofos, isazofos, 1 to 4), in which the active compound I is 4-5-(3.5- methyl bromide, methyl isothiocyanate, oxamyl, sodium dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole azide, thiaxazafen, BYI-1921 (test name), and MAI-08015 3-yl)-2-methyl-N-(2-oxo-2-(2.2.2-trifluoroethyl)amino (test name). ethylbenzamide. 0034 Active ingredient group P ( removing chemi 0045 (6) cals): acriflavine, albendazole, atovaguone, azithromycin, 0046. The insecticidal, miticidal, nematicidal, microbi bithionol, bromofenofos, cambendazole, carnidazole, chlo cidal, or bactericidal composition according to any one of roquine, claZuril, clindamycin hydrochloride, clorSulon, 1 to 4, in which the active compound I is (Z)-4-5-(3.5- closantel, coumaphos, cymiaZol, dichlorophen, diethylcar dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3- bamazine, diminaZene, disophenol, dithiazanine iodide, yl-N-(methoxyiminomethyl)-2-methylbenzamide. doxycycline hydrochloride, doramectin, emodepside, epri 0047 7 nomectin, febantel, fenbendazole, flubendazole, furazoli 0048. A method for controlling pests and diseases char done, glycalpyramide, imidocarb, ivermectin, levamisole, acterized in that a treatment is conducted with the one or two mebendazole, mefloquine, melarsamine hydrochloride, met active compound(s) I as described in 1 and the one or more ronidazole, metyridine, milbemycin oxime, monepantel, active compound(s) II as described in 1 at the same time morantel tartrate, moxidectin, nicarbazin, niclosamide, or at different times that are close to each other. nitroscanate, nitroxynil, omphalotin, oxantel pamoate, oxan 0049 (8) tel tartrate, Oxfendazolee, oxibendazole, oxyclozanide, 0050. A method for controlling pests characterized in that pamaquine, phenothiazine, piperazine adipate, piperazine a treatment is conducted with the one or more active citrate, piperazine phosphate, PNU-97333 (paraherquamide compound(s) I as described in 1 and the one or more active A), PNU-141962 (2-deoxyparaherquamide), praziquantel, compound(s) II as described in 3 at the same time or at primaquine, propetamphos, propoXur, pyrantel pamoate, different times that are close to each other. pyrimethamine, Santonin, Selamectin, Sulfadimethoxine, Sul 0051 9 fadoxine, sulfamerazine, Sulfamonomethoxine, Sulfam 0.052 A chemical for controlling a pest parasitic to honey oildapsone, thiabendazole, tinidazole, toltraZuril, tribro bees comprising at least one of 4-5-(3,5-dichlorophenyl)- msalan, and triclabendazole. 4,5-dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl 0035 Active ingredient group Q (antifungal agents): N-2-oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide, ketoconazole and miconazole nitrate. (Z)-4-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihy 0036 Active ingredient group R (antimicrobial agents): droisoxazole-3-yl-N-(methoxyiminomethyl)-2-methylben amoxicillin, amplicillin, bethoxazin, bithionol, bronopol, Zamide, and salts thereof. cefapirin, cefazolin, cefauinome, ceftiofur, chlortetracy 0053 (10) cline, clavulanic acid, danofloxacin, difloxacin, dinitolmide, 0054 The chemical for controlling a pest parasitic to enrofloxacin, florfenicol, lincomycin, lomefloxacin, marbo honey bees according to 9. in which the pest parasitic to floxacin, miloxacin, mirosamycin, nitrapyrin, norfloxacin, honeybees is Varroa mite, Tropilaelaps clareae, or Acarapis octhillinone, ofloxacin, orbifloxacin, oxolinic acid, oxytetra woodi. cycline, penicillin, Streptomycin, thiamphenicol, tiamulin 0.055 (11) fumarate, tilmicosin phosphate, acetylisovaleryltylosin, 0056. The chemical for controlling a pest parasitic to tylosin phosphate, tulathromycin, valnemulin, calcinated honey bees according to 10, in which the pest parasitic to shell calcium (calcium oxide), Talaromyces, genus honey bees is Varroa mite. Trichoderma, and genus Coniothyrium. 0057 12 0037 (2) 0.058 Amethod for controlling the pest parasitic to honey 0038. The insecticidal, miticidal, nematicidal, microbi bees, in which the chemical for controlling the pest parasitic cidal, or bactericidal composition according to 1, compris to honey bees according to 9 is used. ing the active compound II selected from the active ingre dients M. Effects of the Invention 0039) 3 0059. The composition of the present invention and the 0040. The insecticidal, miticidal, nematicidal, microbi method of the present invention provide excellent synergis cidal, or bactericidal composition according to 2, compris tic control effects to a variety of pests, and provide sufficient ing the active compound II selected from the active ingre synergistic control effects also to pests acquired resistances dient group M consisting of chlorantraniliprole, to conventional pesticides. Accordingly, the present inven cyantraniliprole, flubendiamide, gamma-cyhalothrin, cycla tion can provide a useful novel pesticide composition and an niliprole, tetraniliprole, spinosad, spinetoram, metaflumi effective control method using the composition. Zone, flupyradifurone, flometoquin, bifenthrin, and flufenoxuron. MODES FOR CARRYING OUT THE 0041) 4 INVENTION 0042. The insecticidal, miticidal, nematicidal, microbi 0060. One of the first active ingredients of the composi cidal, or bactericidal composition according to 3, compris tion of the present invention is 4-5-(3,5-dichlorophenyl)-4, ing the active compound II selected from the active ingre 5-dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl-N- US 2017/O 135347 A1 May 18, 2017

2-oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide ascorbic acid, lactic acid, gluconic acid, and citric acid; and hereinafter, referred to as Compound (1) that is known as a salt of amino acid, Such as glutamic acid and aspartic acid. an isoxazoline-Substituted benzamide compound. This is a 0065. Among the first active ingredient compounds I in well-known compound, and is described in WO2005/ the present invention, examples of a compound that can O85216. become a metal salt by a conventional procedure include a salt of an alkali metal. Such as lithium, Sodium, and potas sium; a salt of an alkaline earth metal. Such as calcium, (1) barium, and magnesium; and a salt of aluminum. 0066. The second active ingredient compounds II of the FC s composition of the present invention are well-known as insecticidal, miticidal, nematicidal, molluscicidal, microbi C O cidal, or bactericidal compounds, and specific examples thereof are shown in Table 1 with the compound symbols. f N1 N1c, The first active ingredient compound I in the present inven C CH, O tion, that is, each of Compound (1) and Compound (2) can be used in combination with each of the second active ingredient compounds II shown in Table 1. Specific 0061 The other one of the first active ingredients of the examples of the combination include “Compound (1)+Com composition of the present invention is (Z)-4-5-(3,5-dichlo pound (a) and “Compound (2)+Compound (gy). Due to rophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl)-N- appearances of resistant pests or resistant microbes, and due (methoxyiminomethyl)-2-methylbenzamide hereinafter, to lack of insecticidal or microbicidal spectra and residual activities in these compounds, spraying amounts and spray referred to as Compound (2) that is known as an isoxazo ing frequencies of the chemicals tend to be increased, which line-substituted benzamide compound. This is a well-known in turn increases risk to humans, , and aquatic compound, and is described in WO2007/026965. organisms. Thus, improvements in some of these com pounds are required not only for control effects, but also for (2) environmental safety. FC O NN TABLE 1. No. Compound Name (Common Name) C OCH 8. abamectin b acephate C acetamiprid d afidiopyropen C CH, O e afoxolaner alanycarb 9. aldicarb l allethrin 0062. The first active ingredient compounds of the com i azamethiphos position of the present invention, Compound (1) and Com azinphos-ethyl & azinphos-methyl pound (2), have optically active Substances caused by one bacillus thuringiensis asymmetric carbon atom existing on an isoxazoline ring, and l bendiocarb the optically active substances may encompass racemates or l benfluthrin O benfuracarb optically active Substances having any enantiomeric benSultap CXCCSSS. C bifenthrin 0063 Also, the first active ingredient compound of the r bioallethrin S bioresmethrin composition of the present invention, Compound (2), may bistrifluron encompass a mixture of geometric isomers containing l buprofezin E-bodies with any percentages. w butocarboxim W carbaryl 0064. Among the first active ingredient compounds in the X carbofuran present invention, that is, among Compounds (1) and Com y carbosulfan Z. cartap pounds (2), (hereinafter, abbreviated as the “first active 88 chlorantraniliprole ingredient compounds I), examples of a compound that can ab chlorethoxyfos become an acid addition salt by a conventional procedure 80 chlorfeinapyr include a salt of a hydrohalic acid. Such as hydrofluoric acid, ad chlorfenvinphos hydrochloric acid, hydrobromic acid, and hydroiodic acid; a 8t chlorfluaZuron af chlormephos salt of an inorganic acid, such as nitric acid, Sulfuric acid, ag chlorpyrifos phosphoric acid, chloric acid, and perchloric acid; a salt of ah chlorpyrifos-methyl a Sulfonic acid, such as methanesulfonic acid, ethanesulfonic ai chromafenozide a. clothianidin acid, trifluoromethanesulfonic acid, benzenesulfonic acid, ak cyanophos and p-toluenesulfonic acid; a salt of a carboxylic acid. Such al cyantraniliprole as formic acid, acetic acid, propionic acid, trifluoroacetic 8 cyclaniliprole acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, 8 cycloprothrin malic acid, Succinic acid, benzoic acid, mandelic acid, US 2017/O 135347 A1 May 18, 2017

TABLE 1-continued TABLE 1-continued No. Compound Name (Common Name) Compound Name (Common Name) cyfluthrin muscalure beta-cyfluthrin nitenpyram cyhalothrin novaluron gamma-cyhalothrin noviflumuron lambda-cyhalothrin omethoate cypermethrin Oxydemeton-methyl Zeta-cypermethrin parathion-methyl cyphenothrin permethrin cyromazine phenothrin deltamethrin phenthoate diafenthiuron phorate diazinon phosalone dichlorvos phosmet diflubenzuron phoxim dimethoate pirimicarb dimethylvinphos pirimiphos-methyl dinotefuran profenofos diofenolan brothiofos disulfoton pymetrozine emamectin-benzoate pyrifluguinazon empenthrin pyriprole endosulfan pyriproxy fen alpha-endosulfan e resmethrin EPN roteinOne esfenvalerate silafluofen ethiofencarb spinetoram ethiprole spinosad etofenprox spirotetramat etrimfos Sulfotep enitrothion Sulfoxaflor enobucarb ebufenozide enoxycarb efubenzuron enthion S efluthrin envalerate erbufos fipronil etrachlorvinphos lometoquin etramethrin lonicamid d-tetramethrin 8ZOl etramethylfluthrin lubendiamide etraniliprole flucycloXuron hiacloprid flucythrinate hiamethoxam flufenerim hiocyclam ClOXOl hiodicarb flufiprole hiofanox fluhexafon hiometon flumethrin olfenpyrad lupyradifurone trifumuron fluvalinate NC-515 au-fluvalinate MES382 onofos MIE-1209 urathiocarb ZDI-2SO1 halofenozide acequinocyl heptafluthrin acrinathrin hexaflumuron amidoflumet hydramethylnon amitraz S imidacloprid aZocyclotin imiprothrin benzoximate l indoxacarb bifenazate indoxacarb-MP bromopropylate isoprocarb clofentezine CX isoxathion cyenopyrafen lepimectin cyflumetofen lufenuron dicofol malathion dienochlor meperfluthrin etoxazole metaflumizone fenazaquin metaldehyde fenbutatin oxide methacrifos fenpyroximate methamidophos flua.crypyrim methidathion formetanate methomyl halfenprox menoprene hexythiazox methoxychlor milbemectin methoxyfenozide propargite metofluthrin spirodiclofen US 2017/O 135347 A1 May 18, 2017

TABLE 1-continued TABLE 1-continued Compound Name (Common Name) Compound Name (Common Name) spiromesifen kasugamycin tebufenpyrad proquinazid NA-89 quinoxyfen benalaxyl fempiclonil benalaxyl-M tudioxonil furalaxy chlozolinate metalaxyl iprodione metalaxyl-M procymidone ofurace Vinclozolin oxadixy edifenphos bupirimate iprobenfos ethirimol isoprothiolane hymexazol pyrazophos benomy biphenyl carbendazim chloroneb uberidazole icloran hiabendazole etridiazole hiophanate-methyl quintozene diethofencarb tecnaZene ethalboxam tolclofos-methyl Zoxamide Bacillus subtilis pencycuron aZaconazole fluopicolide bitertanol diflumetorim bromuconazole benodanil climbazole benzovindiflupyr i diclobutrazol bixafen difenoconazole boscalid diniconazole carboxin diniconazole-M enfuram epoxiconazole luopyram etaconazole flutolani fenarimol fluxapyroxad fenbuconazole urametpyr fluotrimazole isofetamide fluquinconazole isopyrazam flusiazole mepronil flutriafol oxycarboxin furconazole penflufen hexaconazole penthiopyriad imazalil Sedaxane imibenconazole thifluzamide ipconazole azoxystrobin metconazole columoxystrobin myclobutanil dimoxystrobin nuarimol enestrobin Oxpoconazole fumarate enoxastrobin pefurazoate amoxadone penconazole enamidone prochloraz enaminstrobin propiconazole flufenoxystrobin prothioconazole fluoxastrobin pyrifenox kresoxim-methyl pyrisoxazole mandestrobin simeconazole metominostrobin ebuconazole orysastrobin etraconazole pyrametostrobin triadimefon pyraoxystrobin triadimenol pyribencarb-methyl trifumizole S pyriminostrobin triforine Ericlopyricarb triticonazole trifloxystrobin aldimorph amisulbrom dodemorph-acetate cyazofamid empropidin dinocap empropimorph luazinam piperalin meptylidinocap spiroxamine entin h tridemorph tributyltin oxide enhexamid silthiofam enpyrazamine ametoctradin validamycin cyprodinil polyoxins mepanipyrim polyoxin-D pyrimethanil benthiavalicarb-isopropyl blasticidin-s dimethomorph US 2017/O 135347 A1 May 18, 2017

TABLE 1-continued cidal, microbicidal, or bactericidal effects are clearly enhanced compared to when those chemicals are used No. Compound Name (Common Name) individually, and rapid insecticidal, miticidal, nematicidal, m flumorph molluscicidal, microbicidal, or bactericidal effects are given. mk iprovalicarb Second, broad insecticidal, miticidal, nematicidal, mollus ml mandipropamid cicidal, microbicidal, or bactericidal spectra and longer l pyrimorph l valifenalate residual activities are induced, which have not been seen in O phthalide any of the conventional insecticides, miticides, nematicides, mp pyroquilon molluscicides, microbicides, and bactericides. Third, spray Ind tricyclazole ing amounts can be reduced compared to when those chemi carpropamid S diclocymet cals are used individually. int enoxanil 0068 That is, the composition of the present invention acilbenzolar-S-methyl and the method of the present invention provide synergistic my probenazole W isotianil insecticidal, miticidal, nematicidal, molluscicidal, microbi X iadinil cidal, or bactericidal effects. The synergistic insecticidal, my aminarin miticidal, nematicidal, molluscicidal, microbicidal, or bac Z. bordeaux mixture tericidal effects cannot be expected from an individual l cheshunt mixture l basic copper carbonate insecticidal, miticidal, nematicidal, molluscicidal, microbi C copper hydroxide cidal, or bactericidal effect that each of the chemicals ind copper naphthenate provides, and thus usefulness of the composition of the le copper oleate present invention and the method of the present invention is l copper oxychloride ng copper Sulfate that the certain control effects can be provided to a variety ill basic copper Sulfate of pests than the case where each of the compounds is used ni oxine copper individually. ni calcium polysulfide 0069. Among the compounds shown in Table 1 above, K Sulfur l amobam the compounds whose control effects are synergistically ill ferbam improved in combination with the first active ingredient ill mancOZeb compound I are shown in Table 2. O maneb metiram Ind polycarbamate TABLE 2 l propineb S thiram Compound Name Compound Name Ziram No. (Common Name) No. (Common Name) captain 88 chlorantraniliprole al cyantraniliprole w folpet 8 cyclaniliprole 8 gamma-cyhalothrin W chlorothalonil C8 flubendiamide ey tetraniliprole X dichlofuanid Cl spinosad el spinetoram ny tolylfluanid dc metaflumizone ci flupyradifurone Z. guaZatine bx flometoquin C bifenthrin O8. iminoctadline-albesilate Ce flufenoxuron O iminoctadline-triacetate OC anilazine od dithianon Ot chinomethionat 0070 The one or two first active ingredient compound(s) O fluoroimide I and the one or more second active ingredient compound(s) Og cyflufenamid II in the present invention can be applied to a variety of Ol cymoxanil methods as described below. oi diclomezine oi dodine 0071 1. Simultaneous applications, that is, OK erimzone O usulfamide 0.072 a) Mixed applications (i.e., for example, as mix Ol flutiani tures for immediate uses such as formula, or mixtures Oil osetyl-aluminium in tanks) and OO metrafenone O Oxathiapiprolin 0.073 b) Individual applications (i.e., applications with Oq picarbutraZox individual tanks), or, O pyriofenone 0.074 2. Sequential individual applications, in which OS ebufloquin O olprocarb order of the applications generally does not affect the Ol triazoxide results of the control method in any way. OW potassium hydrogen carbonate 0075 Accordingly, the method for controlling harmful OW Sodium hydrogen carbonate OX Chinese mushroom mycelium extract organism, mites, nematodes, molluscs, harmful microbes, oy Chinese mushroom carpophore extract and bacteria is conducted by applying at least one of the first OZ BCF-082 active ingredient compounds I and at least one of the second pa NNF-0721 active ingredient compounds II separately or together, or pb ZF-9646 applying a mixture of at least one of the first active ingre dient compounds I and at least one of the second active 0067. The characteristics of the composition of the pres ingredient compounds II to seeds, , or soil by spraying ent invention and the method of the present invention are as or dusting, before or after seeding, or before or after budding follows. First, insecticidal, miticidal, nematicidal, mollusci of the plants. US 2017/O 135347 A1 May 18, 2017

0076. In the composition of the present invention and the (Leguminivora glycinivorella), Soybean podworm (Mat method of the present invention, the optimal mixing ratio sumuraeses phaseoli), Grape berry moth (Endopiza (ratio by weight) of the first active ingredient compound I viteana), Smaller tea tortrix (Adoxophyes honnai), Summer and the second active ingredient compound II is within a fruit tortrix (Adoxophyes Oranafasciata), Asiatic leafroller range of 100:1 to 1:100, preferably 20:1 to 1:20, and (Archips breviplicanus), Apple tortrix (Archipsfiascocuprea particularly 10:1 to 1:10, depending on characteristics of the nus), Oriental tea tortrix (Homona magnanima), Dark fruit compounds. tree tortrix (Pandemis heparana), Pine moth (Dendrolimus 0077. In the composition of the present invention and the spectabilis), Japanese hemlock caterpillar (Dendrolimus method of the present invention, although the preferable superans), Japanese bamboo lappet moth (Euthrix alb treating amounts of the active ingredient compounds vary Omaculata), Drinker moth (Euthrix potatoria), Oriental lap depending on types of the pests to be controlled, it is usually pet (Gastropacha Orientalis), Kunugia undans, Kunugia 0.1 g ai/ha to 1,000 g ai/ha for the first active ingredient yamadai, Tomato hornworm (Manduca quinquemaculata), compound I and 0.1 g ai/ha to 1,000 g ai/ha for the second Tobacco hornworm (Manduca sexta), Fall webworm moth active ingredient compound II; and preferably 1 g ai/ha to (Hyphantria cunea), Mulberry tiger moth (Lemyra impari 300 g ai/ha for the former and 1 g ai/ha to 300 g ai/ha for the lis), Eilema fiscodorsalis, Eilema laevis, Oriental tussock latter. moth (Artaxa subflava), Euproctis piperita, Tea tussock 0078. The composition of the present invention can be moth (Euproctis pseudoconspersa), Swan moth (Sphragei applied to "agricultural pests and "agricultural diseases” dus similis), Gypsy moth (Lymantria dispar), White-spotted which inflict horticultural crops, trees, and the like: “live tussock moth (Orgvia thvellina), Rice green caterpillar (Na stock pests that are parasitic to livestock and poultry; ranga aenescens), Adris tyrannus, Sweet potato leaf worm “sanitary pests’ that adversely affect living environments of (Aedia leucomelas), Cabbage armyworm (Mamestra bras humans, such as houses; and mites, nematodes, and mol sicae), Oriental armyworm (Pseudaletia separata), Lawn luscs, which rise and inflict in Such situations. Specific grass cutworm (Spodoptera depravata), Southern army examples of the pests, mites, nematodes, molluscs, and worm (Spodoptera eridania), Beet armyworm (Spodoptera diseases which can be controlled with the composition of the exigua), Fall armyworm (Spodoptera fugiperda), Cotton present invention will be listed below, but not limited leafworm (Spodoptera littoralis), Common cutworm thereto. (Spodoptera litura), Cotton bollworm (Helicoverpa armig 0079. Examples of the pests are as follows. Hymenoptera era), Oriental tobacco budworm (Helicoverpa assulta), insects, such as Chestnut gall wasp (Dryocosmus kuriphi Tobacco budworm (Heliothis virescens), Corn earworm lus), Argentine ant (Linepithema humile), Army ant (Eciton (Helicoverpa zea), Black cutworm (Agrotis ipsilon), Turnip burchelli, E. Schmitti), Japanese carpenterant (Camponotus moth (Agrotis segetum), Asiatic common looper (Au japonicus), Pharaoh ant (Monomorium pharaonis), Bulldog tographa nigrisigna), Threespotted plusia (Ctenoplusia ant (Myrmecia spp.), Fire ant (Solenopsis spp.), Asian giant agnata), Soybean looper (Pseudoplusia includens), Cabbage hornet (Vespa mandarina), Japanese yellow hornet (Vespa looper (Trichoplusia ni), Japanese giant looper (Ascotis simillima), Large rose sawfly (Arge pagana), European pine selenaria), Large white (Pieris brassicae), Cabbage white sawfly (Neodiprion sertifer), Chestnut sawfly (Apethymus butterfly (Pieris rapae crucivora), Straight swift (Parnara kuri), Cabbage sawfly (Athalia infimata), and Turnip Sawfly guttata), cotton leafworm (Alabama argillacea), and Sugar (Athalia rosae). cane borer (Diatraea Sacharalis). 0080 Lepidoptera insects, such as Pear leaf miner (Buc I0081. Diptera insects, such as Melon (Bactrocera culatrix pyrivorella), Tea leafroller (Caloptilia theivora), cucurbitae). Oriental fruit fly (Bactrocera dorsalis), Queen Apple leafminer (Phyllonorycter ringoniella), leaf sland fruit fly (Bactrocera tryoni), Japanese orange fly miner (Phyllocnistis citrella), Sweetpotato leaffolder (Hel (Bactrocera tsuneonis), Mediterranean fruit fly (Ceratitis cystogramma triannulella), Pink bollworm (Pectinophora capitata), Mexican fruit fly (Anastrepha ludens), Apple gossypiella), Persimmon fruit moth (Stathmopoda mas maggot (Rhagoletispomonella), Rice leaf miner (Agromyza inissa), Peach fruit moth (Carposina Sasakii), Allium leaf Oryzae), Pea leaf miner (Chromatomyia horticola), Cabbage miner (Acrolepiopsis sapporensis), Yam leafminer (Acrole leafminer (Liriomyza brassicae), Tomato leaf miner (Liri piopsis Suzukiella), Peach leafminer (Lyonetia clerkella), omyza bryoniae), Stone leek leafminer (Liriomyza chinen Lyonetia prunifoliella malinella, Diamondback moth (Plu sis), Pea leafminer (Liriomyza huidobrensis), Tomato leaf tella xylostella), Rice stem borer (Chilo suppressalis), Blue miner (Liriomyza sativae), Serpentine leafminer (Liriomyza grass webworm (Parapediasia teterrella), Cabbage web trifolii), Japanese fruit fly (Drosophila Suzukii), Smaller rice worm (Hellula undalis), Rice leafroller (Cnaphalocrocis leaf miner (Hydrellia griseola), Tsetse fly (Glossina morsi medinalis), Yellow peach moth (Conogethes punctiferalis), tans, G palpalis). Forest fly (Hippobosca equina), Sheep ked Cucumber moth (Diaphania indica), Mulberry pyralid (Gly (Melophagus Ovinus), Onion fly (Delia antiqua), Seed corn phodes pyloalis), Asian corn borer (Ostrinia firmacalis), maggot (Delia platura), Beet leaf miner (Pegomya cunicu European corn borer (Ostrinia nubilalis), Adzuki bean borer laria), Lesser house fly ( canicularis), Sheep headfly (Ostrinia Scapulalis), Lesser corn Stalk borer (Elasmopalpus (Hydrotaea irritans), Sweat fly (Morellia simplex), Face fly lignosellus), Limabean pod borer (Etiella Zinckenella), (Musca autumnalis), (Musca domestica), Austra Peach tree borer (Synanthedon exitiosa), Cherry tree borer lian bush fly (Musca vetustissima), Horn fly (Haematobia (Synanthedon hector), Toleria romanovi. Oriental moth irritans), Stable fly (Stomoxys calcitrans), Caliphora lata, (Monemafiavescens), Parasa consocia, Parasa lepida, Bottle fly (Calliphora vicina), Old World screw-worm fly Parasa siniea, Artona martini, Illiberis pruni, Illiberis (Chrysomya bezziana), Blow fly (Chrysomya chloropyga), rotundata, Carpenter moth (Cossus insularis), Codling moth Oriental latrine fly (Chrysomya megacephala), New World (Cydiapomonella), Plum fruit moth (Grapholita dimorpha), screw-worm fly (Cochliomyia hominivorax), Black blow fly Oriental fruit moth (Grapholita molesta), Soybean pod borer (Phormia regina), Northern blowfly (Protophormia terrae US 2017/O 135347 A1 May 18, 2017 novae), Australian sheep blowfly (Lucilia cuprina), Green I0084. insects, such as Asian citrus psyllid bottle fly (Lucilia illustris), Common green bottle fly (Lu (Diaphorina citri), Pear Sucker (Psylla pyrisuga), Camelia cilia sericata), Bot (Cuterebra spp.), Human botfly spiny whitefly (Aleurocanthus cameliae), Orange spiny (Dermatobia hominis), Horse nose bot fly (Gasterophilus whitefly (Aleurocanthus spiniferus), Silverleaf whitefly (Be haemorrhoidalis), Horse botfly (Gasterophilus intestinalis), misia argentifolii), Sweetpotato whitefly (Bemisia tabaci), Throat bot fly (Gasterophilus nasalis), Warble fly (Hypo Citrus whitefly (Dialeurodes citri), Greenhouse whitefly derma bovis), Common cattle grub (Hypoderma lineatum), (Trialeurodes vaporariorum), Pea (Acyrthosiphon Sheep nasal bot fly (Oestrus ovis), Flesh fly (Sarcophaga pisum), Cowpea aphid (Aphis craccivora), Black bean aphid carnaria), Flesh fly (Sarcophaga peregrina), Splayed deer (Aphis fabae), Soybean aphid (Aphis glycines), Cotton aphid fly (Chrysops caecutiens), Deerfly (Chrysops suavis), Com (Aphis gossypii), Green apple aphid (Aphispomi), Spiraea mon horse fly (Haematopota pluvialis), Greenhead horse fly (Tabanus nigrovittatus), Horse fly (Tabanus trigonus), Soy aphid (), Foxglove aphid (Aulacorthum bean pod gall midge (Asphondylia yushimai), Hessian fly Solani), Leafcurl plum aphid (Brachycaudus helichrysi), (Mayetiola destructor), Orange wheat blossom midge (Sito Cabbage aphid (Brevicoryne brassicae), Walnut aphid diplosis mosellana), Biting midge (Culicoides arakawae), (Chromaphis juglandicola), Russian wheat aphid (Diura Black gnat (Leptoconops nipponensis), Prosimulium phis noxia), Rosy apple aphid (Dysaphis plantaginea), yezoensis, Black fly (Simulium ochraceum), African malaria Mealy plum aphid (Hyalopteruspruni), Turnip aphid (Lipa mosquito (Anopheles gambiae). Anopheles hyrcanus sinesis, phis erysimi), Potato aphid (Macrosiphum euphorbiae), Anopheles lesteri, Yellow fever mosquito (Aedes aegypti), Blackmargined aphid (Monellia carvella), Green peach Asian tiger mosquito (Aedes albopictus), House mosquito aphid (Myzus persicae), Lettuce aphid (Nasonovia ribisini (Culex pipiens molestus), House mosquito (Culex pipiens gri). Onion aphid (Neotoxoptera formosana), Bird cherry pallens), Culex tritaeniorhynchus, Sandfly (Phlebotomus oat aphid (Rhopalosiphum padi), Rice root aphid (Rhopalo spp.), and Moth fly (Telmatoscopus albipunctatus). siphum rufiabdominalis), Corn leaf aphid (Sitobion akebiae), English grain aphid (Sitobion avenae), Greenbug 0082 Siphonaptera insects, such as Hen flea (Cerato (Schizaphis graminum), Black citrus aphid ( phyllus gallinae), Chigoe flea (Tungapenetrans), Dog flea aurantii), Brown citrus aphid (Toxoptera citricida), Wooly (Ctenocephalides canis), Cat flea (Ctenocephalides felis), apple aphid (Eriosoma lanigerum), Grape phylloxera (Viteus Sticktight flea (Echidnophaga gallinacea), Human flea vitifolii), Indian wax scale (Ceroplastes ceriferus), Red wax (Pulex irritans), and Oriental rat flea (Xenopsylla cheopis). scale (Ceroplastes rubens), Citricola Scale (Coccus pseudo I0083 Coleoptera insects, such as Tobacco beetle (Lasio magnoliarum), California red scale (AOnidiella aurantii), derma serricorne), Common bean weevil (Acanthoscelides San jose scale (Comstockaspis perniciosa), Tea Scale obtectus), Adzuki bean beetle (Callosobruchus chinensis), (Fiorinia theae), Peony scale (Pseudaonidia paeoniae), Grape borer (Xylotrechuspyrrhoderus), Asian long-horn Mulberry scale (Pseudaulacaspis pentagona), White peach beetle (Anoplophora glabripennis), White-spotted longicorn scale (Pseudaulacaspis prunicola), Citrus Snow scale (Un beetle (Anoplophora malasiaca), Japanese pine Sawyer aspis citri), Euonymus scale (Unaspis euonymi), Arrowhead (Monochamus alternatus), Yellow-spotted longicorn beetle scale (Unaspis vanonensis), Giant margarodid scale (Drosi (Psacothea hilaris), Colorado potato beetle (Leptinotarsa cha corpulenta), Cottony cushion scale (Iceryapurchasi), decemlineata), Mustard leaf beetle (Phaedon cochleariae), Cotton mealy bug (Phenacoccus Solani), Citrus mealybug Rice leaf beetle (Oulema oryzae), Reaf beetle (Demotina (Planococcus citri), Japanese mealybug (Planococcus fasciculata), Cucurbit leaf beetle (Aulacophora femoralis), kuraunhiae), Comstock mealybug (Pseudococcus com Beet flea beetle (Chaetocnema concinna), Northern corn stocki), Grape mealybug (Pseudococcus maritimus), Small rootworm (Diabrotica barberi), Southern corn rootworm brown planthopper (Laodelphax striatella), Brown rice (Diabrotica undecimpunctata), Western corn rootworm planthopper (Nilaparvata lugens), White-backed rice plan (Diabrotica virgifera), Striped flea beetle (Phyllotreta strio thopper (Sogatella furcifera), Grape Leafhopper (Epiacan lata), Solanum flea beetle (Psylliodes angusticollis), Mexi thus strainineus), Indian cotton leafhopper (Amrasca dev can been beetle (Epillachna varivestis), Large twenty-eight astans), Beardsley leafhopper (Balclutha Saltuella), Aster spotted ladybird (Epilachna vigintioctomaculata), leafhopper (Macrosteles fasci?ions), Macrosteles strifrons, Twentyeight-spotted ladybird (Epillachna vigintioctopunc Green rice leafhopper (Nephotettix cincticeps), Grape Leaf tata), Epuraea domina, Pollen beetle (Melligethes aeneus), hopper (Arboridia apicalis), Potato Leafhopper (Empoas Peach curculio (Rhynchites heros), Sweetpotato weevil (Cy cafabae), Empoasca nipponica, Tea green leafhopper (Em las formicarius), West Indian Sweet potato weevil (Euscepes poasca Onuki), Bean's Smaller green leafhopper (Empoasca postfasciatus), Boll weevil (Anthonomus grandis), White Sakai), Sloe bug (Dolycoris baccarum), Cabbage bug (Eu fringed beetle (Graphognatus leucoloma), Black vine wee rydema rugosa), Whitespotted spined bug (Eysarcoris vil (Otiorhynchus sulcatus), Alfalfa weevil (Hyperapostica), aeneus), Eysarcoris lewisii, White-spotted Stink bug (Eysar Granary weevil (Sitophilus granarius), Maize weevil (Sito coris ventralis). Sheildbug (Glaucias subpunctatus), Brown philus zeamais), Hunting billbug (Sphenophorus venatus marmorated Stink bug (Halyomorpha halys), Eastern green vestitus), Rice weevil (Echinocnemus squameus), Rice Stink bug (Nezara antennata), Southern green Stink bug water weevil (Lissohoptrus Oryzophilus), Yellow mealworm (Nezara viridula), Redbanded stink bug (Piezodorus guil (Tenebrio molitor), Red flour beetle (Tribolium castaneum), dinii), Redbanded shield bug (Piezodorus hybneri), Brown Sweetpotato wireworm (Melanotus fortnumi), Sugarcane winged green bug (Plautia crossota), Japanese black rice wireworm (Melanotus tamsuyensis), Citrus flower chafer bug (Scotinophora lurida), Bean bug (Riptortus clavatus), (Gamnetisjucunda), Yellowish elongate chafer (Heptophyl Rice bug (Leptocorisa chinensis), Rice Stink bug (Cletus lapicea), Cupreous chafer (Anomala cuprea), Soybean punctiger), Squash bug (Paradasynus spinosus), Rhopalid beetle (Anomala rufocuprea), Japanese beetle (Popillia bug (Rhopalus maculatus), True chinch bug (Blissus leu japonica), and Rove beetle (Paederusfiscipes). copterus), Oriental chinch bug (Cavelerius saccharivorus), US 2017/O 135347 A1 May 18, 2017

Seed bug (Togo hemipterus), Red cotton bug (Dysdercus 0092. Siphonostomatoida crustaceans, such as Sealouse cingulatus), Blood-sucking bug (Rhodnius prolixus), Kissing (Caligus curtus, C. elongatus) and Salmon louse (Lep bug (Triatoma dimidiata), Kissing bug (Triatoma infestans), eophtheirus salmonis). green Stink bug (Acrosternum hilare), brown Stink bug 0093 Astigmata: Acarina, such as Storage mite (Glycy (Euschistus servus), Southern green Stink bug (Nezara phagus destructor), House itch mite (Glycyphagus domes viridula), Tarnished plant bug (Lygus lineolaris), Dichelops ticus), Brown-legged grain mite (Aleuroglyphus ovatus), fircatus, Sugarcane Spittlebug (Mahanarva fimbriolata), Cheese mite (Trophagus putrescentiae), Tyrophagus simi Azalea lace bug (Stephanitispyrioides), Bed bug (Cimex lis, Bulb mite (Rhizoglyphus robini), Feather mite (Pteroli lectularius), Pale greenplant bug (Apolygus spinolae), West chus obtusus), Feather mite (Megninia cubitalis), American ern tarnished plant bug (Lygus hesperus), Tarnished plant house dust mite (Dermatophagoidesfarinae), House dust bug (Lygus lineolaris), Rice Stink bug (Stenodema Sibiri mite (Dermatophagoidespteronyssinus), Chorioptic mange cum), Sorghum plant bug (Stenotus rubrovittatus), Rice leaf mite (Chorioptes bovis), Dog ear mite (Otodectes cynotis), bug (Trigonotylus caelestialium), Island fleahopper (Halti Psoroptic mite (Psoroptes communis), Rabbit ear mite (Pso cus insularis), and Cotton fleahopper (Pseudatomoscelis roptes cuniculi), Sheep scab mite (Psoroptes ovis), Itch mite seriatus). (Sarcoptes scabiei), and Cat mange mite (Notoedres cati). 0085 Thysanoptera insects, such as Flower thrips 0094 Oribatida: Acarina, such as Haplochthonius sim (Frankliniella intonsa), Western flower thrips (Frankliniella plex. occidentalis), Greenhouse thrips (Heliothrips haemor rhoidalis), Yellow tea thrips (Scirtothrips dorsalis), Melon 0.095 Prostigmata: Acarina, such as Chelacaropsis thrips (Thrips palmi). Onion thrips (Thrips tabaci), and moorei, Cheyletiella blakei, Rabbit fur mite (Cheyletiella Japanese gall-forming thrips (Ponticulothrips diospyrosi). parasitovorax), Cheyletiella vasguri, Cheyletus eruditus, Cheyletus malaccensis, Dog follicle mite (Demodex canis), I0086) Psocodea insects, such as Body louse (Menacan Cat follicle mite (Demodex cati), Face mite (Demodexfoli thus cornutus), Small body louse (Menacanthus pallidulus), culorum), Wheat curl mite (Aceria tulipae), Pear rust mite Chicken body louse (Menacanthus stramineus), Chicken (Eriophyes chibaensis), Peach bud mite (Eriophyes insidi shaft louse (Menopon gallinae), Chickenhead louse (Cuclo Osus), Pearleaf blister mite (Eriophyespyri), Tea rust mite togaster heterographa), Brown chicken louse (Goniodes (Acaphylla theavagrams), Tomato russet mite (Aculops lyco dissimilis), Fluff louse (Goniodes gallinae), Large hen louse persici), Pink citrus rust mite (Aculopspelekassi), Apple rust (Goniodes gigas), Wing louse (Lipeurus caponis), Cattle mite (Aculus Schlechtendali), Citrus rust mite (Phyllocop chewing louse (Damalinia bovis), Cat louse (Felicola sub truta oleivOra), Broad mite (Polyphagotarisonemus latus), rostrata), Dog biting louse (Trichodectes canis), Short Cyclamen mite (Phytonemuspallidus), Tarsonemid mite nosed cattle louse (Haematopinus eurysternus), Tail Switch (Tarsonemus bilobatus), Oligonychus Shinkai, Citrus red louse (Haematopinus quadripertusus), Large pig louse mite (Panonychus citri), Spider mite (Panonychus mori), (Haematopinus suis), Buffalo louse (Haematopinus tuber European red mite (Panonychus ulmi), Kanzawa spider mite culatus), Dog Sucking louse (Linognathus Setosus), Long (Tetranychus kanzawai). Two-spotted spider mite (Tetrany nosed cattle louse (Linognathus vituri), Rabbit louse (Hae chus urticae), Penthaleus erythrocephalus, Winter grain modipsius ventricosus), Little blue cattle louse (Solenopotes mite (Penthaleus major), Eutrombicula wichmanni, Trom capillatus), Head louse (Pediculus humanus), Mouse louse biculid mite (Helenicula miyagawaii), Leptotrombidium aka (Polyplax serratus), and Crab louse (Pthirus pubis). mushi, Leptotrombidium pallida, and Tsutsugamushi mite 0087 Orthoptera insects, such as Desert locust (Schisto (Leptotrombidium scutellare). cerca gregaria), Australian plague locust (Chortoicetes ter 0096 Metastigmata: Acarina, such as English fowl tick minifera), Migratory locust (Locusta migratoria), Lesser (Argas persicus), Soft tick (Ornithodoros moubata), Relaps paddy grasshopper (Oxyajaponica), Rice grasshopper (Oxya ing fever tick (Ornithodoros turicata), Spinose ear tick yezoensis), Emma field cricket (Teleogryllus emma), and (Otobius megnini), Lone star tick (Amblyomma america Oriental mole cricket (Gryllotalpa Orientalis). num), Gulf coast tick (Amblyomma maculatum), Haemaph 0088 Dictyoptera insects, such as German cockroach lysalis campanulata, Haemaphysalis flava, Bush tick (Hae (Blattella germanica), American cockroach (Periplaneta maphysalis longicornis), Haemaphysalis megaspinosa, americana), Smoky-brown cockroach (Periplaneta fuligi Tortoise tick (Hyalomma aegyptium), Mediterranean tick nosa), Japanese cockroach (Periplanetaiaponica), Daikoku (Hyalomma marginiatum), Tropical cattle tick (Boophilus dry-wood termite (Cryptotermes domesticus), Western dry microplus), Ixodes nipponensis, Ixodes ovatus, Western wood termite (Incisitermes minor), Formosan Subterranean black-legged tick (Ixodes pacifcus), Taiga tick (Ixodes per termite (Coptotermesformosanus), Japanese Subterranean sulcatus), Castor bean tick (Ixodes ricinus), Black-legged termite (Reticulitermes speratus), and Black-winged subter tick (Ixodes scapularis), Tropical horse tick (Anocentor ranean termite (Odontotermes formosanus). nitens), Rocky Mountain wood tick (Dermacentor ander soni), Pacific Coast tick (Dermacentor Occidentalis), Ornate 0089 Collembola: Hexapoda, such as Rootfeeding cow tick (Dermacentor reticulatus), American dog tick springtail (Onychiurus folsomi), Onychiurus Sibiricus, and (Dermacentor variabilis), Rhipicentor spp., American cattle Garden springtail (Bourletiella hortensis). tick (Rhipicephalus annulatus), and Brown dog tick (Rhi 0090. Isopoda crustaceans, such as Pill bug (Armadil picephalus Sanguineus). lidium vulgare) and Common rough woodlouse (Porcellio 0097 Mesostigmata: Acarina, such as Red mite (Derma scaber). nyssus gallinae), Tropical rat mite (Ornithonyssus bacoti), 0.091 Arguloida crustaceans, such as Argulus coregoni, Northern fowl mite (Ornithonyssus Sylviarum), Honeybee Japanese fishlouse (Argulusjaponicus), and Argulus Scuti mite (Varroa destructor), and Varroa mite (Varroajacob formis. soni). US 2017/O 135347 A1 May 18, 2017 11

0098. Architaenioglossa: , such as Apple snail nematode (Pratylenchus loosi), Cobb’s root-lesion nema (Pomacea canaliculata). tode (Pratylenchuspenetrans), and Walnut root-lesion nema 0099 : Gastropoda, such as Giant Afri tode (Pratylenchus vulnus). can Snail (Achatina fitica), Terrestrial slug (Limax margin 0105. Oxyurida Nematoda, such as Pinworm (Enterobius atus), Slug (Meghimatium bilineatum), Korean round Snail vermicularis), Equine pinworm (Oxyuris equi), and Rabbit ( despecta Sieboldiana), and (Euhadra pinworm (Passalurus ambiguus). peliomphala). 0106 Ascaridida Nematoda, such as Pig roundworm 0100 Enoplida Nematoda, such as Giant kidney worm (Ascaris suum), Horse roundworm (Parascaris equorum), (Dioctophyma renale). Thread worms (Capillaria annulata), Dog roundworm (Toxascaris leonina), Dog intestinal round Cropworm (Capillaria contorta), Capillary liver worm worm (Toxocara canis), Feline roundworm (Toxocara cati), (Capillaria hepatica), Capillaria perforans, Capillaria phil Large cattle roundworm (Toxocara vitulorum), Anisakis ippinensis, Capillaria Suis, Whipworm (Trichuris discolor), spp., Pseudoterranova spp., Caecal worm (Heterakis galli Whipworm (Trichuris ovis), Pig whipworm (Trichuris suis), narum), and Chicken roundworm (Ascaridia galli). Human whipworm (Trichuris trichiura), Dog whipworm 0107 Spirurida Nematoda, such as Guinea worm (Dra (Trichuris vulpis), and Pork worm (Trichinella spiralis). cunculus medimensis), Gnathostoma doloresi, Gnathostoma 0101 Rhabditida Nematoda, such as Intestinal thread hispidum, Gnathostoma nipponicum, Reddish-coloured worm (Strongyloides papillosus), Strongyloides planiceps, worm (Gnathostoma spinigerum), Dog Stomach worm (Ph Pig threadworm (Strongyloides ransomi). Threadworm vsaloptera canis), Cat Stomach worm (Physaloptera felidis, (Strongyloides stercoralis), and Micronema spp. P. praeputialis), Feline/canine stomach worm (Physaloptera 0102 Strongylida Nematoda, such as Hookworm (Ancy rara), Eye worm ( callipaeda), Bovine eyeworm lostoma braziliense), Dog hookworm (Ancylostoma cani (Thelazia rhodesi), Large mouth Stomach worm (Draschia num), Old World hookworm (Ancylostoma duodenale), Cat megastoma), Equine stomach worm (Habronema micro hookworm (Ancylostoma tubaeforme), The Northern hook stoma), Stomach worm (Habronema muscae), Gullet worm worm of dogs (Uncinaria Stenocephala), Cattle hookworm (Gongylonema pulchrum). Thick stomach worm (Ascarops (Bunostomum phlebotomum), Small ruminant hookworm strongylina), Parafilaria (Parafilaria bovicola), Parafilaria (Bunostomum trigonocephalum), New World hookworm multipapillosa, Stephanofilaria Okinawaensis, Bancroft (Necator americanus), Cyathostomum spp., Cylicocyclus filaria (Wuchereria bancrofti), Brugia malayi, Neck thread spp., Cylicodontophorus spp., Cylicostephanus spp., worm (Onchocerca cervicalis). Onchocerca gibsoni, Cattle Strongylus asini, Strongylus edentatus, Blood worm filarial worm (Onchocerca gutturosa). Onchocerca volvulus, (Strongylus equinus), Blood worm (Strongylus vulgaris), Bovine filarial worm (Setaria digitata), Peritoneal worm Large-mouthed bowel worm (Chabertia ovina), Nodular (Setaria equina), Setaria labiatopapillosa, Setaria mar worm (Oesophagostomum brevicaudatum), Nodule worm shalli, Dog heartworm (Dirofilaria immitis), and African eye (Oesophagostomum columbianum), Nodule worm (Oesoph worm (Loa loa). agostomum dentatum), Nodular worm (Oesophagostomum georgianum), Nodular worm (Oesophagostomum maplesto 0.108 Acanthocephala, such as Moniliformis monilifor nei). Nodular worm (Oesophagostomum quadrispinulatum), mis and Giant thorny-headed worm (Macracanthorhynchus Nodular worm (Oesophagostomum radiatum), Nodular hirudinaceus). worm (Oesophagostomum venulosum), Syngamus Skriabi 0109 Pseudophyllidean cestodes, such as Fish tapeworm nomorpha, Gapeworm (Syngamus trachea), Swine kidney (Diphyllobothrium latum), Diphyllobothrium nihonkaiense, worm (Stephanurus dentatus), Cattle bankrupt worm (Coo Manson tapeworm (Spirometra erinaceieuropaei), and Dipl.- peria oncophora), Red Stomach worm (Hyostrongylus rubi Ogonoporus grandis. dus), Stomach hair worm (Trichostrongylus axei), Tricho 0110. Cyclophyllidean cestodes, such as Mesocestoides strongylus colubriformis, Oriental trichoStrongylus lineatus, Chicken tapeworm (Raillietina Cesticillus), Fowl (Trichostrongylus Orientalis), Red Stomach worm (Haemon tapeworm (Raillietina echinobothrida), Chicken tapeworm chus contortus), Cattle stomach worm (Mecistocirrus digi (Raillietina tetragona), Canine tapeworm (Taenia hydati tatus), Brown stomach worm (Ostertagia Ostertagi), Com gena), Canine tapeworm (Taenia multiceps), Sheep measles mon lungworm (Dictyocaulus filaria), Bovine lungworm (Taenia ovis), Dog tapeworm (Taenia pisiformis), Beef (Dictyocaulus viviparus). Thin-necked intestinal worm tapeworm (Taenia saginata), Tapeworm (Taenia serialis), (Nematodirus filicollis), Swine lungworm (Metastrongylus Pork tapeworm (Taenia solium), Feline tapeworm (Taenia elongatus), Lungworm (Filaroides hirthi), Lungworm taeniaeformis), Hydatid tapeworm (Echinococcus granulo (Crenosoma aerophila), Fox lungworm (Crenosoma vulpis), sus), Small fox tapeworm (Echinococcus multilocularis), Rat lungworm (Angiostrongylus cantonensis), French heart Echinococcus oligarthrus, Echinococcus vogeli, Rat tape worm (Angiostrongylus vasorum), and Protostrongylus spp. worm ( diminuta), Dwarf tapeworm (Hyme 0103) Aphelenchida Nematoda, such as Rice white tip molepis mana), Double-pored dog tapeworm (Dipylidium nematode (Aphelenchoides besseyi) and Pine wood nema caninum), Amoebotaenia sphenoides, Choanotaenia infin tode (Bursaphelenchus xylophilus). dibulum, Metroliasthes Coturnix, Equine tapeworm (Anop 0104 Tylenchida Nematoda, such as Potato cyst nema locephala magna), Cecal tapeworm (Anoplocephala perfo tode (Globodera rostochiensis), Cereal cyst nematode (Het liata), Dwarf equine tapeworm (Paranoplocephala erodera avenae), Soybean cyst nematode (Heterodera gly manillana), Common tapeworm (Moniezia benedeni), cines), Peanut root-knot nematode (Meloidogyne arenaria), Sheep tapeworm (Moniezia expansa), and Stilesia spp. Northern root-knot nematode (Meloidogyne hapla), South 0111 Strigeidida trematodes, such as Pharyngostomum ern root-knot nematode (Meloidogyne incognita), Javanese cordatum, Blood fluke (Schistosoma haematobium), Blood root-knot nematode (Meloidogyne javanica), Coffee root fluke (Schistosomajaponicum), and Blood fluke (Schisto lesion nematode (Pratylenchus coffeae), Tea root-lesion Soma mansoni). US 2017/O 135347 A1 May 18, 2017

0112 Echinostomida trematodes, such as Echinostoma 0.125 Diseases of Eddoe: Leaf mold (Cladosporium cinetorchis, Echinostoma hortense, Giant liver fluke (Fas colocasiae), Dry rot (Fusarium oxysporum f.sp. colocasiae), ciola gigantica), Common liver fluke (Fasciola hepatica), Black rot (Ceratocystis sp.), Phytophthora blight (Phy Fasciolopsis buski, and Homalogaster paloniae. tophthora colocasiae), Pythium aristosporum, P. myrioty 0113 Plagiorchiida trematodes, such as Dicrocoelium lum, and Bacterial soft rot (Pectobacterium carotovorum). chinensis, Lancet liver fluke (Dicrocoelium dendriticum), 0.126 Diseases of Alliaceae crops: Leaf spot (Heterospo African lancet fluke (Dicrocoelium hospes), Eurytrema coe rium allii). Alternaria leaf spot (Alternaria porri), Leaf spot lomaticum, Pancreatic fluke (Eurytrena pancreaticum), (Pleospora herbarum, Stemphylium botryosum, S. vesi Paragonimus miyazaki, Paragoninus Ohirai, and Lung carium), Pink root rot (Pyrenochaeta terrestris, Pyreno fluke (Paragonimus westermani). chaeta sp.), Leaf blight (Botrytis cinerea, B. byssoidea, B. 0114. Opisthorchida trematodes, such as Amphimerus squamosa), Gray mold (Botrytis cinerea), Onion gray mold spp., Chinese liver fluke (Clonorchis sinensis), Cat liver neck rot (Botrytis allii), Small sclerotial rot (Botrytis squa fluke (Opisthorchisfelineus), Southeast Aasian liver fluke mosa), Leaf blight (Ciborinia allii), Dry rot (Fusarium (Opisthorchis viverrini), Pseudamphistomum spp., Oxysporum), Fusarium basal rot (Fusarium oxysporum f.sp. Metorchis spp., Parametorchis spp., Intestinal fluke (Het allii, F solani f. sp. radicicola), Onion fitsarium basal rot erophyes heterophyes), Metagonimus yokokawai, and (Fusarium oxysporum f.sp. cepae), Rust (Puccinia allii), Pygidiopsis summa. Smut (Urocystis cepulae), Allium white rot (Sclerotium 0115 Amebas, such as Entamoeba histolytica, or E. cepivorum), Southern blight (Athelia rolfsii), Damping-off invadens. (Rhizoctonia solani, Pythium sp.), Downy mildew (Perono 0116 Piroplasmida: Sporozoa, such as Babesia big spora destructor), Phytophthora blight (Phytophthora nico emina, Babesia bovis, Babesia caballi, Babesia Canis, Babe tianae), Leaf blight (Phytophthoraporri), Onion soft rot sia felis, Babesia gibsoni, Babesia ovata, Cytauxzoon felis, (Burkholderia cepacia), Bacterial rot (Pseudomonas Theileria annulata, Theileria mutans, Theileria Orientalis, cichorii, P. marginalis pv. marginalis, Erwinia sp.), Bacte and Theileria parva. rial basal bulb rot (Pseudomonas sp.), and Bacterial soft rot 0117 Haemosporida: Sporozoa, such as Haemoproteus (Pectobacterium carotovorum). mansoni, Leucocytozoon caulleryi, Plasmodium falciparum, 0127 Diseases of asparagus: Leaf spot (Cercospora Plasmodium malariae, Plasmodium ovale, and Plasmodium asparagi), Stemphylium leaf spot (Stemphylium botryosum), vivax. and Stem blight (Phomopsis asparagi). 0118 Eucoccidiorida: Sporozoa, such as Caryospora I0128. Diseases of Chinese yam: Brown rot (Fusarium spp., Eimeria acervulina, Eimeria bovis, Eimeria brunetti, Oxysporum, F Solani f. sp. pisi, f. sp. radicicola), Anthra Eimeria maxima, Eimeria necatrix, Eimeria ovinoidalis, cnose (Glomerella cingulata), and Leaf spot (Pseudophloeo Eimeria Stiedae, Eimeria tenella, Isospora Canis, Isospora sporella dioScoreae). felis, Isospora suis, Tizzeria alleni, Tizzeria anseris, TvZZe I0129. Diseases of rice: Stem rot (Helminthosporium sig ria perniciosa, Wenyonella anatis, Wenyonella gagari, moideum var. irregulare), Brown spot (Cochliobolus miya Cryptosporidium canis, Cryptosporidium felis, Cryptospo beanus), Seedling blight (Phoma sp., Trichoderma viride, ridium hominis, Cryptosporidium meleagridis, Cryptospo Fusarium Solani, Gibberella avenacea, Mucor fragilis, ridium muris, Cryptosporidium parvum, Sarcocystis canis, Rhizopus arrhizus, R. Chinensis, R. oryzae, Pythium arrhe Sarcocystis Cruzi, Sarcocystis felis, Sarcocystis hominis, nomanes, P. graminicola, P irregulare, P. spinosum, P Sarcocystis miescheriana, Sarcocystis neurona, Sarcocystis Sylvaticum), False Smut (Villosiclava virens), “Bakanae' tenella, Sarcocystis Ovalis, Toxoplasma gondii, Hepatozoon disease (Gibberellafiujikuroi), Blast (Magnaporthe grisea), canis, and Hepatozoon felis. Stem rot (Magnaporthe salvinii), Sheath blight (Thanate 0119 Vestibuliferida: Ciliata, such as Balantidium coli. phorus cucumeris), Bacterial grain rot (Burkholderia gladi 0120 Trichomonadida: Mastigophora, such as Histoma oli, B. glumae), Bacterial seedling blight (Burkholderia nas meleagridis, Pentatrichomonas hominis, and Trichomo plantarii), Bacterial brown Stripe (Acidovorax avenae Subsp. FaaS tena X. avenae), Bacterial leaf blight (Xanthomonas Oryzae pv. 0121 Diplomonadida: Mastigophora, such as Giardia Oryzae), and Bacterial palea browning (Pantoea anamatis). intestinalis, Giardia muris, Hexamita meleagridis, and Hex 0.130 Diseases of wheat varieties: Speckled leaf blotch amita parva. (Mycosphaerella graminicola), Glume blotch (Phaeospha 0122 Kinetoplastida: Mastigophora, Such as Leishmania eria nodorum), Spot blotch (Cochliobolus sativus), Barley donovani, Leishmania infantum, Leishmania major; Leish stripe (Pyrenophora graminea), Barley net blotch (Pyreno mania tropica, Trypanosoma bruceii gambiense, Trypano phora teres), Barley powdery mildew (Blumeria graminis f. Soma bruceii rhodesiense, Trypanosoma Cruzi, Trypanosoma sp. hordei). Wheat powdery mildew (Blumeria graminis f. equiperdun, and Trypanosoma evansi. Harmful organisms sp. tritici), Rye powdery mildew (Blumeria graminis f. sp. in the horticulture field, and external or internal parasites of secalis), Eyespot (Tapesia acuformis, T. yallundae), Sclero livestock, poultry, pets, or the like, which can be controlled tinia Snow blight (Sclerotinia borealis), Ergot (Claviceps by using the compound of the present invention, are not purpurea), Fusarium blight (Fusarium Crookwellense, F limited to the examples above. culmorum, Gibberella avenacea, G zeae), Take-all (Gaeu 0123. Meanwhile, specific examples of the diseases will mannomyces graminis), Snow mold (Monographella niva be listed below. lis), Cephalosporium stripe (Cephalosporium gramineum), 012.4 Diseases of koniac: Dry rot (Fusarium oxysporum, Scald (Rhynchosporium secalis), Stem rust (Puccinia F solani f.sp. radicicola), Stem rot (Athelia rolfsii), Root rot graminis), Barley leaf rust (Puccinia hordei), Brown rust (Pythium aristosporum), Bacterial leaf blight (Acidovorax (Puccinia recondita), Stripe rust (Puccinia striiformis var. koniaci), and Soft rot (Erwinia carotovora Subsp. caroto Striiformis), Flag Smut (Urocystis agropyri), Covered Smut vora). (Ustilago hordei). Loose Smut (Ustilago nuda), Bunt (Tille US 2017/O 135347 A1 May 18, 2017

tia caries, T. laevis), Stinking Smut (Tilletia controversa), eola), Ascochyta blight (Ascochytapisi), Brown spot Typhula Snow blight (Tiphula incarnate, Tishikariensis var. (Didymella fabae), Powdery mildew (Erysiphe pisi, Spha ishikariensis), Foot-rot (Ceratobasidium cornigerum), erotheca fuliginea), Gray mold (Botrytis cinerea), Chocolate Browning root rot (Pythium graminicola, P horinouchiense, spot (Botrytis cinerea, B. elliptica, B. fabae), Stem rot Piwayamai, P. Okanoganense, P. paddicum, P. vanterpoolii, (Sclerotinia sclerotiorum), Crown and root rot (Calonectria P. volutum), Bacterial halo blight (Pseudomonas Syringae ilicicola), Root rot (Fusarium arthrosporioides, F. avena pV. coronafaciens), and Bacterial black node (Pseudomonas ceum, F sporotrichioides), Fusarium root-rot (Fusarium Syringae pv. Syringae). cuneirostrum), Fusarium wilt (Fusarium oxysporum f.sp. 0131 Diseases of grasses: Dollar spot (Sclerotinia adzukicola), Stem wilt (Fusarium avenaceum, Foxysporum homoeocarpa), Fairy rings (Bovista dermoxantha, Cono f. sp. fabae), Root rot (Fusarium Solani f.sp. pisi), Anthra cybe apala, Lepista subnuda, Lycoperdon curtisii, L. perla cnose (Colletotrichum lindemuthianum), Anthracnose (Col tum, Marasmius Oreades), Rhizoctonia patch (Ceratoba letotrichum phaseolorum), Anthracnose (Colletotrichum tri sidium spp.), Brown patch, Large patch (Rhizoctonia folii, C. truncatum, Glomerella glycines, Gloeosporium sp.), Solani), Rust (Puccinia Zoysiae), and Pythium blight (Py Brown stem rot (Phialophora gregata), Soybean rust (Pha thium graminicola, P. periplocum, P. vanterpoolii). kopsora pachyrhizi), Rust (Uromyces phaseoli var. azuki 0132 Diseases of Sugarcane: Leaf Scorch (Stagonospora cola), Rust (Uromyces phaseoli var. phaseoli), Rust (Uro sacchari), Top rot (Fusarium moniliforme var. majus, Gib myces viciae-fabae var. viciae-fabae), Southern blight berellafiujikuroi, G. fijikuroi var. subglutinans), Orange rust (Athelia rolfsii), Downy mildew (Peronospora manshurica), (Puccinia kuehnii), Brown rust (Puccinia melanocephala), Phytophthora root and stem rot (Phytophthora soiae), Phy and Sugarcane Smut (Sporisorium scitamineum). tophthora vignae f. sp. adzukicola, Bacterial pustule 0.133 Diseases of corns: Southern leafblight (Cochliobo (Xanthomonas campestris pv. glycines), Bacterial blight lus heterostrophus), Northern leaf blight (Setosphaeria tur (Pseudomonas Savastanoi pv. glycinea), Halo blight cica), Seedling blight (Gibberella avenacea, Penicillium (Pseudomonas Savastanoi pv. phaseolicola), and Pseudomo sp.), Southern rust (Pucciniapolysora), Corn Smut (Ustilago nas Syringae pv. Syringae. maydis). Sheath blight (Thanatephorus cucumeris), and 0140 Diseases of hops: Powdery mildew (Oidium sp., Browning root rot (Pythium arrhenomanes, Pgraminicola). Sphaerotheca intermedia), Gray mold (Botrytis cinerea), 0134 Diseases of bananas: Black sigatoka (Mycospha Hop wilt (Verticillium albo-atrum), and Downy mildew erellafijiensis), Yellow Sigatoka leaf spot (Mycosphaerella (Pseudoperonospora humuli). musicola), and Panama disease (Fusarium oxysporum f.sp. 0141 Diseases of fig trees: Souring (Candida sorbosa, cubense). Candida sp., Pichia kluyveri), Fig scab (Sphacelona cari 0135 Diseases of Zingiberaceae crops: Leaf spot (My cae), Gray mold (Botrytis cinerea), Ceratocystis canker cosphaerella Zingiberis), Leaf spot (Phyllosticta Zingiberis), (Ceratocystis fimbriata), White root rot (Rosellinia neca Blast (Pyricularia Zingiberis), Rhizoctonia Solani, and Root trix), Anthracnose (Glomerella cingulata), Rust (Phakop rot (Pythium ultimum, P. Zingiberis). Sora nishidana), Rhizopus rot (Rhizopus stolonifer var. 0.136 Diseases of sugar beets: Cercospora leaf spot (Cer stolonifer), and White powdery rot (Phytophthora palm cospora beticola), Ramularia leaf spot (Ranularia beticola), ivora). Leaf spot (Pleospora betae), Powdery mildew (Erysiphe 0.142 Diseases of mulberries: Powdery mildew (Phyllac betae), Leaf blight/Root rot (Thanatephorus cucumeris), tinia moricola), Twig blight (Hypomyces Solani f.sp. mori, Aphanomyces root rot (Aphanomyces cochlioides), and f. sp. pisi, Gibberella baccata), Dieback (Diaporthe nomu Damping-off (Pleospora betae, Fusarium sp., Colletotri rai), White root rot (Rosellinia necatrix), Violet root rot chum dematium, Rhizoctonia Solani, Aphanomyces coch (Helicobasidium longisporum), Red rust (Aecidium mori), lioides, Pythium debaryanum). Bacterial blight (Pseudomonas Syringae pv. mori), and 0.137 Diseases of spinach: Leaf spot (Cercospora beti Shoot soft rot (Pectobacterium carotovorum). cola), Leaf mold (Cladosporium variabile), Fusarium wilt 0.143 Diseases of roses: Stem canker (Leptosphaeria (Fusarium oxysporum f.sp. spinaciae), Anthracnose (Col coniothyrium), Powdery mildew (Podosphaerapannosa, letotrichum dematium f. spinaciae), Foot rot (Rhizoctonia Uncinuliella simulans), Black spot (Diplocarpon rosae), Solani), Root rot (Aphanomyces cochlioides), Downy mil Botrytis blight (Botrytis cinerea), Rust (Kuehneola japonica, dew (Peronospora farinosa f. sp. spinaciae), Damping-off Phragmidium fusiforme, P. mucronatum, P. rosae-multiflo (Pythium aphanidermatum, P. myriotylum, P. paroecan rae), Downy mildew (Peronospora sparsa), and Crown gall drum, P. ultimum var. ultinum), and Bacterial leaf spot (Agrobacterium tumefaciens). (Pseudomonas Syringae pv. Spinaciae). 0144. Diseases of strawberries: Leaf spot (Mycosphaer 0.138. Diseases of grapes: Isariopsis leaf spot (Pseudo ella fragariae), Powdery mildew (Sphaerotheca aphanis cercospora vitis), Anthracnose (Elsinoe ampelina), Powdery var. aphanis), Gray mold (Botrytis cinerea), Fusarium wilt mildew (Uncinula necator), Gray mold (Botrytis cinerea), (Fusarium oxysporum f.sp. fragariae), Leaf blight (Pho Swelling arm (Diaporthe kyushuensis), Bud blight (Dia mopsis obscurans), Crown rot (Colletotrichum acutatum, C. porthe rudis), Dead arm (Phomopsis viticola), Ripe rot fragariae, Glomerella Cingulata), Phytophthora rot (Phy (Colletotrichum acutatum, Glomerella cingulata), Rust tophthora cactorum, P. nicotianae, Phytophthora sp.), and (Physopella ampelopsidis), and Downy mildew (Plas Red stele (Phytophthora fragariae). mopara viticola). 0145 Diseases of loquats: Entomosporium leaf spot 0139 Diseases of Fabaceae crops: Purple stain (Cer (Diplocarpon mespili), Gray leaf spot (Pestalotia eriobot cospora kikuchii), Ring spot (Cercospora Zonata), Brown rifolia, Pestalotiopsis fitnereal, P. neglecta), White root rot Leaf spot (Mycosphaerella arachidis), Leaf spot (My (Rosellinia necatrix), Anthracnose (Colletotrichum acuta cosphaerella berkeleyi), Mycosphaerella blight (Mycospha tum, Glomerella cingulata), and Canker (Pseudomonas erella pinodes), Angular leaf spot (Phaeoisariopsis gris syringae pv. eriobotryae). US 2017/O 135347 A1 May 18, 2017 14

0146 Diseases of apples: Fruit spot (Mycosphaerella cinerea), Sclerotinia rot (Sclerotinia Sclerotiorum), pomi). Alternaria blotch (Alternaria mali), Scab (Venturia Fusarium wilt (Fusarium oxysporum f.sp. cucumerinum, f. Inaequalis), Ring rot (Botryosphaeria berengeriana f. sp. sp. lagenariae, f. sp. luffae, f. sp. melonis, f. sp. niveum), piricola), Fly speck (Schizothyrium pomi), Powdery mildew Fusarium basal rot (Fusarium Solani f. sp. cucurbitae), (Podosphaera leucotricha), Blotch (Diplocarpon mali), Phomopsis sp., Root rot (Monosporascus cannonballus), Blossom blight (Monilinia mali), Valsa canker (Valsa cera Plectosporium blight (Monographella cucumerina), Anthra tosperma), White root rot (Rosellinia necatrix), Bitter rot cnose (Colletotrichum Orbiculare, Glomerella cingulata), (Colletotrichum acutatum, Glomerella cingulata), Sooty Southern blight (Athelia rolfsii), Damping-off (Rhizoctonia blotch (Phyllachora ponigena), Violet root rot (Helicoba Solani, Pythium cucurbitacearum, P. debaryanum, P. spino sidium longisporum), Rust (Gymnosporangium yamadae), sum), Downy mildew (Pseudoperonospora cubensis), and Fire blight (Erwinia amylovora). Brown rot (Phytophthora capsici), Phytophthora rot (Phy 0147 Diseases of nashi pears: Black spot (Alternaria tophthora capsici, P. cryptogea, P. melonis, P. nicotianae), kikuchiana), Brown spot (Stemphylium sp.), Scab (Venturia Pythium fruit rot (Pythium aphanidermatum), Bacterial fruit nashicola), Ring rot (Botryosphaeria berengeriana f. sp. blotch (Acidovorax avenae Subsp. citrulli), Bacterial spot piricola), Shoot blight (Botryosphaeria dothidea), Powdery (Xanthomonas campestris pv. cucurbitae), Marginal blight mildew (Phyllactinia mali), Phomopsis canker (Phomopsis (Pseudomonas marginalis pv. marginalis, P viridiflava), and fiukushi), Coral spot (Nectria cinnabarina), White root rot Angular leaf spot (Pseudomonas Syringae pv. lachrymans). (Rosellinia necatrix), Anthracnose (Colletotrichum acuta 0154 Diseases of Japanese chestnuts: Endothia canker tum, Glomerella cingulata), Rust (Gymnosporangium asi (Cryphonectria parasitica) and Anthracnose (Glomerella aticum), Phytophthora fruit rot (Phytophthora cactorum, P. Cingulata). syringae), Bacterial black spot (Pseudomonas Syringae pv. 0155 Diseases of Brassicaceae vegetables: White spot syringae), and Fire blight (Erwinia amylovora). (Pseudocercosporella capselae), Black leg (Leptosphaeria 0148 Diseases of apricots: Scab (Venturia carpophila), maculans). Alternaria leaf spot (Alternaria brassicae, A. Zonate leaf spot (Grovesinia pruni), Brown rot (Monilinia brassicicola, A. japonica). Alternaria Sooty spot (Alternaria fructicola, M. fructigena, M. laxa), Shoot blight (Coryneum brassicicola), Black leg (Phoma wasabiae), Gray mold sp.), Anthracnose (Gloeosporium sp., Colletotrichum acu (Botrytis cinerea), Snow mold (Sclerotinia nivalis, Tiphula tatum), and Bacterial shot hole (Xanthomonas campestris japonica, T incarnate, T ishikariensis var. ishikariensis), pV. pruni). Sclerotinia rot (Sclerotinia sclerotiorum), Yellows 0149 Diseases of Japanese apricots: Scab (Venturia car (Fusarium oxysporum f. sp. conglutinans), Yellows pophila), Gray mold (Botrytis cinerea), Zonate leaf spot (Fusarium oxysporum f.sp. raphani), Verticillium black spot (Grovesinia pruni), Brown rot (Monilia mumecola, (Verticillium albo-atrum, V. dahliae), Yellows (Verticillium Monilinia fructicola, M. laxa), Anthracnose (Colletotrichum dahliae), Verticillium wilt (Verticillium longisporum), acutatum, Glomerella cingulata), Sooty blotch (Peltaster Anthracnose (Colletotrichum dematium, C. destructivum, C. sp.), Chloranthy (Blastospora Smilacis), and Bacterial can higginsianum), Damping-off (Rhizoctonia Solani), Club root ker (Pseudomonas syringae pv. morsprunorum, Erwinia (Plasmodiophora brassicae), White rust (Albugo mac sp.). rospora), White rust (Albugo wasabiae), Downy mildew 0150 Diseases of Japanese plums: Plum pockets (Taph (Hyaloperonospora brassicae), Downy mildew (Perono rinapruni), Brown rot (Monilinia fructicola, M. fructigena), spora alliariae-wasabi), Downy mildew (Peronospora Anthracnose (Colletotrichum acutatum), and Bacterial leaf parasitica), Damping-off (Pythium buismaniae, P. Zingib spot (Xanthomonas arboricola pv. pruni). eris, Rhizoctonia Solani), Damping-off (Pythium sp.), Black 0151. Diseases of peaches: Leaf curl (Taphrina defor rot (Xanthomonas campestris pV. campestris), Head rot mans), Scab (Venturia carpophila), Blister canker (Botry (Pseudomonas fluorescens, P. viridiflava, Pectobacterium Osphaeria berengeriana f. sp. perscicae), Powdery mildew carotovorum), Bacterial black spot (Pseudomonas syringae (Podosphaerapannosa, P. tridactyla var. tridactyla), Brown pV. maculicola), and Bacterial soft rot (Pectobacterium rot (Monilinia fructicola, M. fructigena), Phomopsis rot carotovorum, P wasabiae). (Phomopsis sp.), Cytospora canker (Leucostoma persoonii), 0156 Diseases of papayas: Phytophthora blight (Phy Anthracnose (Colletotrichum acutatum, Glomerella Cingu tophthora nicotianae). lata), Fruit red spot (Ellisembia sp.), Brown rust (Tranz schelia discolor), and Bacterial shot hole (Xanthomonas 0157 Diseases of okras: Brown leaf mold (Pseudocer arboricola pv. pruni, Pseudomonas Syringae pv. Syringae, cospora abelmoschi), Alternaria rot (Alternaria alternata), Brenneria nigrifluens). Pod spot (Phoma exigua var. exigua), Powdery mildew 0152 Diseases of cherries: Cylindrosporium leaf spot (Leveillula taurica), Gray mold (Botrytis cinerea), Black (Mycosphaerella cerasella, Blumeriella jaapi), Brown rot root rot (Thielaviopsis basicola), Damping-off (Rhizoctonia (Monilinia fructicola, M. fructigena, M. laxa), Young-fruit Solani, Pythium ultimum var. ultimum, Pythium sp.), and rot (Monilinia kusanoi), White root rot (Rosellinia necatrix), Pseudomonas cichorii, P viridiflava. Anthracnose (Colletotrichum acutatum, Glomerella Cingu 0158 Diseases of mangos: Anthracnose (Colletotrichum lata), Rhizopus rot (Rhizopus stolonifer var. Stolonifer), and acutatum, Glomerella Cingulata). Bacterial canker (Pseudomonas syringae, P. S. pv. Syringae, 0159. Diseases of : Greasy spot (Mycosphaerella P. viridiflava). citri, M. horii), Scab (Elsinoefawcettii), Black rot (Alter 0153 Diseases of pepos: Scab (Cladosporium cucumeri naria citri), Common green mold (Penicillium digitatum), num), Corynespora leaf spot (Corynespora Cassicola), Blue mold (Penicillium italicum), Gray mold (Botrytis Gummy stem blight (Didymella bryoniae), Powdery mildew cinerea), Melanose (Diaporthe citri), Melanose like blemish (Erysiphe betae, Leveillula taurica, Oidium sp., Podospha (Alternaria citri, Diaporthe rudis), White root rot (Ro era xanthii, Sphaerotheca fuliginea), Gray mold (Botrytis sellinia necatrix), Anthracnose (Glomerella cingulata), US 2017/O 135347 A1 May 18, 2017

Brown rot (Phytophthora citricola, P. citrophthora, P. nico tans), Bacterial wilt (Ralstonia Solanacearum), and Necrotic tianae, P. palmivora), and Citrus canker (Xanthomonas citri leaf spot (Pseudomonas cichorii). Subsp. citri). 0169 Diseases of potatoes: Early blight (Alternaria 0160 Diseases of kiwifruits: Sooty spot (Pseudocer Solani), Dry rot (Fusarium oxysporum, Fusarium Solani f. cospora actinidiae), Soft rot (Botryosphaeria dothidea, sp. eumarti, f.sp. radicicola), Anthracnose (Colletotrichum Lasiodiplodia theobromae, Diaporthe sp.), Gray mold coccodes), Black Scurf (Thanatephorus cucumeris), Pow (Botrytis cinerea), White root rot (Rosellinia necatrix), dery Scab (Spongospora subterranea f. sp. subterranea), Anthracnose (Colletotrichum acutatum, Glomerella Cingu Late blight (Phytophthora infestans), Ring rot (Clavibacter lata), Bacterial blossom blight (Pseudomonas marginalis pv. michiganensis Subsp. Sepedonicus), Scab (Streptomyces marginalis, P. syringae pv. Syringae, P viridiflava), and spp.), Bacterial wilt (Ralstonia Solanacearum), Black leg Bacterial canker (Pseudomonas Syringae pv. actinidiae). (Dickeya dianthicola, Pectobacterium atrosepticum, P 0161 Diseases of kaki persimmons: Angular leaf spot carotovorum), and Bacterial soft rot (Pectobacterium caro (Cercospora kaki), Circular leaf spot (Mycosphaerella tovorum). nawae), Black spot (Fusicladium levieri), Fly speck 0170 Diseases of chili peppers and bell peppers: Frogeye (Schizothyrium pomi), Powdery mildew (Phyllactinia kaki leaf spot (Cercospora capsici), Corynespora blight (Coryne cola), Gray mold (Botrytis cinerea), Black leaf spot (Dis spora cassicola), Stemphyrium leaf spot (Stemphylium costroma sp.), and Anthracnose (Glomerella cingulata). lycopersici), Powdery mildew (Leveillula taurica), Gray 0162 Diseases of blueberries: Gray mold (Botrytis mold (Botrytis cinerea), Sclerotinia rot (Sclerotinia Sclero cinerea) and Valdensia leaf blight (Valdensia heterodoxia). tiorum), Fusarium wilt (Fusarium oxysporum), Anthracnose 0163 Diseases of tea plants: Brown round spot (Cer (Colletotrichum acutatum, C. capsici, C. nigrum), Southern cospora chaae, Pseudocercospora Ocellata), Anthracnose blight (Athelia rolfsii), Damping-off (Rhizoctonia Solani), (Discula theae-simensis), Gray blight (Pestalotiopsis long Phytophthora blight (Phytophthora capsici), Bacterial wilt iseta, P theae). White root rot (Rosellinia necatrix), Brown (Ralstonia Solanacearum), Bacterial spot (Xanthomonas blight (Glomerella cingulata), Net blister blight (Exoba campestris pv. vesicatoria), and Bacterial Soft rot (Pecto sidium reticulatum), Blister blight (Exobasidium vexans), bacterium carotovorum). Black rot (Ceratobasidium sp.), and Bacterial shoot blight 0171 Diseases of tobaccos: Brown spot (Alternaria (Pseudomonas Syringae pv. theae). alternata), Sore shin (Rhizoctonia Solani), Black shank 0164 Diseases of shiso: Corynespora leaf spot (Coryne (Phytophthora nicotianae), and Bacterial wilt (Ralstonia spora Cassicola) and Rust (Coleosporium plectranthi). Solanacearum). 0.165 Diseases of sesame: Stem rot (Athelia rolfsii), 0172 Diseases of celery: Early blight (Cercospora apii), Bacterial wilt (Ralstonia Solanacearum), and Bacterial leaf Late blight (Septoria apicola), and Bacterial soft rot (Pec spots (Pseudomonas Syringae pv. Sesami). tobacterium carotovorum). 0166 Diseases of sweet potatoes: Stem rot (Fusarium 0173 Diseases of Japanese honeywort: Sclerotinia rot Oxysporum f.sp. batatas, F solani), Black rot (Ceratocyst (Sclerotinia Sclerotiorum), Fusarium oxysporum f.sp. apii, isfimbriata), Violet root rot (Helicobasidium longisporum), Rust (Puccinia tokvensis), Rhizoctonia Solani, Downy mil Soft rot (Rhizopus stolonifer var. stolonifer; R. tritici), and dew (Plasmopara nivea), and Pythium aphanidermatum, P Soil rot (Streptomyces ipomoeae). apleroticum, Pythium sp. 0167 Diseases of tomatoes: Leaf mold (Mycovellosiella 0.174 Diseases of carrots: Cercospora blight (Cer filva), Cercospora leaf mold (Pseudocercospora filligena), cospora carotae), Leafblight (Alternaria dauci). Alternaria Corynespora target spot (Corynespora Cassicola), Early black rot (Alternaria radicina), Powdery mildew (Erysiphe blight (Alternaria Solani), Leaf spot (Stemphyllium lycoper heraclei), Sclerotinia rot (Sclerotinia minor; S. Sclerotio Sici, S. Solani), Brown root rot (Pyrenochaeta lycopersici), rum), Dry rot (Fusarium solani f.sp. radicicola, Gibberella Powdery mildew (Leveillula taurica, Oidium neolycoper avenacea), Violet root rot (Helicobasidium longisporum), Sici, Oidium sp.), Gray mold (Botrytis cinerea), Stem rot Southern blight (Athelia rolfsii), Southern blight (Athelia (Sclerotinia sclerotiorum), Fusarium wilt (Fusarium Oxysporum f.sp. lycopersici), Crown and root rot (Fusarium rolfsii), Damping-off (Rhizoctonia Solani), Brown blotted Oxysporum f.sp. radicis-lycopersici), Verticillium wilt (Ver root rot (Pythium sulcatum), Crown gall (Agrobacterium ticillium dahliae), Southern blight (Athelia rolfsii), Damp tumefaciens), and Bacterial Soft rot (Pectobacterium caro ing-off (Rhizoctonia Solani, Pythium vexans), Late blight tovorum). (Phytophthora infestans), Bacterial canker (Clavibacter 0.175 Diseases of parsley: Leaf spot (Cercospora apii), michiganensis Subsp. michiganensis), Bacterial wilt (Ral Powdery mildew (Erysiphe heraclei), Phytophthora nicoti stonia Solanacearum), Bacterial spot (Xanthomonas camp anae, and Bacterial soft rot (Pectobacterium carotovorum). estris pv. vesicatoria), and Bacterial soft rot (Pectobacte 0176 Diseases of Aralia elata: Spot anthracnose (Elsinoe rium carotovorum). araliae) and Phytophthora cactorum. 0168 Diseases of eggplants: Leaf mold (Mycovellosiella 0177 Diseases of udos: Leaf spot (Alternariapanax, nattrassii), Leaf spot (Paracercospora egenula), Black Alternaria sp.), Sclerotinia rot (Sclerotinia Sclerotiorum), blight (Corynespora cassicola), Early blight (Alternaria Verticillium wilt (Verticillium dahliae, V nigrescens), South Solani), Powdery mildew (Erysiphe cichoracearum, Leveil ern blight (Athelia rolfsii), and Phytophthora rot (Phy lula taurica, Sphaerotheca fuliginea), Gray mold (Botrytis tophthora cactorum). cinerea), Stem rot (Sclerotinia Sclerotiorum), Fusarium 0.178 Diseases of lettuce. Gray mold (Botrytis cinerea), Oxysporum f.sp. melongenae, Verticillium wilt (Verticillium Stem rot (Sclerotinia sclerotiorum), Root rot (Fusarium dahliae), Brown spot (Phomopsis vexans), Southern blight Oxysporum f.sp. lactucae), Bottom rot (Rhizoctonia Solani), (Athelia rolfsii), Damping-off (Rhizoctonia Solani), Brown Downy mildew (Bremia lactucae), Bacterial spot rot (Phytophthora capsici), Late blight (Phytophthora infes (Xanthomonas axonopodis pv. vitians), Bacterial rot US 2017/O 135347 A1 May 18, 2017

(Pseudomonas cichorii, P. marginalis pv. Marginalis, P 0189 Examples of the honey bees include bumblebees, viridiflava), and Bacterial soft rot (Pectobacterium caroto stingless bees, Apis dorsata, Apis laboriosa, Apis florea, vorum). Apis andreniformis, Apis mellifera, Apis cerama, and Apis 0179 Diseases of Chrysanthemum morifolium: Leaf spot koschevnikovi. Among them, Apis mellifera and Apis cerana (Septoria chrysanthemella), Leaf blight (Septoria obesa), are preferred. The honey bees refer to all members in the Ray blight (Didymella chrysanthemi), Powdery mildew population, including Workers, drones, eggs, larvae, pupae, (Erysiphe cichoracearum var. cichoracearum), Botrytis and queen. blight (Botrytis cinerea), Stem rot (Sclerotinia sclerotio 0190. That is, the composition of the present invention rum), Wilt (Verticillium dahliae), Rust (Phakopsora artemi and the method of the present invention are extremely siae), Rust (Puccinia horiana), Rust (Puccinia tanaceti var. effective to harmful organisms that are resistant to conven tanaceti), Petal blight (Itersonilia perplexans), Southern tional insecticides, such as organophosphorus compounds, blight (Athelia rolfsii), Root and stem rot (Ceratobasidium carbamate compounds and pyrethroid compounds; and cornigerum, Rhizoctonia Solani), Downy mildew (Perono harmful organisms belonging to insects of Coleoptera, spora danica), Phytophthora rot (Phytophthora cactorum, Hymenoptera, Lepidoptera, Diptera, Siphonaptera, Thys Phytophthora sp.), Crown gall (Agrobacterium tumefa anoptera, Hemiptera, Psocodea (Mallophage and Anoplura), ciens), Bacterial wilt (Ralstonia Solanacearum), and Bacte Orthoptera, Dictyoptera, Isoptera, Collembola, or the like: rial stem rot (Pectobacterium carotovorum). crustaceans of Isopoda or the like; mites of Astigmata 0180 Diseases of crown daisies: Leaf blight (Cercospora (Acaridae, Analgidae, Psoroptidae, and Sarcoptidae), Pros chrysanthemi), Anthracnose (Colletotrichum acutatum), and tigmata (Cheyletidae, Demodicidae, Eriophyidae, Tarson Downy mildew (Peronospora chrysanthemi-coronarii). emidae, Tetranychidae, Penthaleidae, and Trombiculidae), 0181 Diseases of sunflowers: Leaf spot (Septoria helian Metastigmata (Argasidae and Ixodidae), Mesostigmata thi), Leaf spot (Alternaria helianthi), Powdery mildew (Ery (Dermanyssidae, Macronyssidae, and Varroidae), or the like; siphe cichoracearum, Golovinomyces cichoracearum var. Gastropoda; and nematodes of Trichocephalida, Rhabditida, latisporus, Oidium sp., Podosphaerafisca), Gray mold Strongylida, Aphelenchida, Tylenchida, Ascaridida, Camal (Botrytis cinerea), Sclerotinia rot (Sclerotinia Sclerotiorum), lanida, Oxyurida, Spirurida, or the like: can effectively be Root and stem rot (Rhizoctonia Solani), Downy mildew controlled with low concentrations. Meanwhile, the compo (Plasmopara halstedii), Bacterial leaf spot (Pseudomonas sition of the present invention and the method of the present syringae pv. helianthi), and Pectobacterium carotovorum. invention have extremely little adverse effects to mammals, fishes, crustaceans, and beneficial insects (useful insects, 0182 Diseases of fuki: Verticillium wilt (Verticillium Such as honey bees and bumble Bees; and natural enemy dahliae) and Southern blight (Athelia rolfsii). insects, such as Aphelinidae, Aphidiidae, Tachinidae, and 0183 Diseases of burdocks: Leaf spot (Phoma exigua Orius), and thus have useful characteristics. var. exigua), Powdery mildew (Podosphaerafisca), Black 0191) When the first active ingredient compound I and streak (Itersonilia perplexans), Black Scurf (Rhizoctonia the second active ingredient compound II shown in Table 1 Solani), Pythium irregulare, and Bacterial spot (Xanthomo are combined in the composition of the present invention, nas campestris pv. nigromaculans). Diseases of plants, the composition of the present invention and the method of which can be controlled by using the compound of the the present invention provide excellent synergistic effects, present invention, are not limited to the examples above. particularly to mites and Hemiptera pests. The Synergistic 0184 Compound (1) and a composition of the present effects are more prominent to spider mites, such as Panony invention containing Compound (1) are useful for control chus citri, Tetranychus urticae, and Tetranychus kanzawai ling Stink bugs, Hemiptera Pentatomidae, which have been among the mites; and to and whiteflies among the problematic in Soybean fields in recent years, or are useful Hemiptera pests. for controlling weevils, Curculionidae Family, which have 0.192 The “plants' herein refers to Tracheophyta, such as been problematic in cotton fields. grain, fruits, and vegetables, which are cultivated as food of 0185. Also, Compound (2) and a composition of the humans; forage crops for livestock, poultry, and the like; present invention containing Compound (2) are useful for ornamental plants for cherishing their appearances; and controlling Stink bugs, Hemiptera Pentatomidae, which plantings at parks, streets, and the like. Specific examples have been problematic in Soybean fields in recent years, or include the plants listed below, but not limited thereto. are useful for controlling weevils, Curculionidae Family, 0193 Pinales plants such as Japanese Red Pine (Pinus which have been problematic in cotton fields. densiflora), Scots Pine (Pinus Sylvestris), and Japanese 0186 Compound (1) and the composition of the present Black Pine (Pinus thunbergii) belonging to Pinaceae or the invention containing Compound (1) are useful for control like. ling pests parasitic to honey bees, which have been prob 0194 Magnoliids such as Pepper (Piper nigrum) belong lematic in recent years. ing to Piperaceae; AVocado (Persea americana) belonging 0187. Also, Compound (2) and the composition of the to Lauraceae; or the like. present invention containing Compound (2) are useful for 0.195 Monocots such as Konjac (Amorphophallus kon controlling pests parasitic to honey bees, which have been jac) and Eddoe (Colocasia esculenta) belonging to Araceae; problematic in recent years. Chinese yam (Dioscorea batatas) and Japanese yam (Di 0188 Examples of the pest parasitic to honey bees OsCorea japonica) belonging to Dioscoreaceae; Leek (Al include honeybee microsporidia (Nosema apis), Varroa lium ampeloprasum var. porrum), Onion (Allium cepa). mite, Acarapis woodi, Aethina tumida, Achroia innotata Rakkyo (Allium chinense), Welsh onion (Allium fistulosum), obscurevittella, and Galleria mellonella (wax moth larvae). Garlic (Allium sativum), Chives (Allium Schoenoprasum), Among them, Varroa mite, Tropilaelaps clareae, and Acara Chive (Allium Schoenoprasum var. foliosum). Oriental garlic pis woodi are preferred. (Allium tuberosum), and Scallion (Alliumxwakegi) belong US 2017/O 135347 A1 May 18, 2017 ing to Alliaceae; Asparagus (Asparagus officinalis) belong Mustard (Brassica rapa var. nipposinica), Napa cabbage ing to Asparagaceae; Coconut palm (Cocos nucifera) and (Brassica rapa Var. pekinensis), Turnip leaf (Brassica rapa Oil palm (Elaeis guineensis) belonging to Arecoideae of var. perviridis), Turnip (Brassica rapa Var. rapa), Garden Arecaceae; Date palm (Phoenix dactylifera) belonging to rocket (Eruca vesicaria), Daikon (Raphanus sativus var. Coryphoideae of Arecaceae; Pineapple (Ananas comosus) longipinnatus), and Wasabi (Wasabia japonica) belonging to belonging to Bromeliaceae; Rice (Oryza sativa) belonging Brassicaceae; Papaya (Carica papaya) belonging to Cari to Ehrhartoideae of Poaceae; Bent grass (Agrostis spp.), caceae; Okra (Abelmoschus esculentus), Cotton plant (Gos Blue grass (Poa spp.), Barley (Hordeum vulgare). Wheat sypium spp.), and Cacao (Theobroma cacao) belonging to (Triticum aestivum, T. durum), and Rye (Secale cereale) Malvaceae; Grape (Vitis spp.) belonging to Vitaceae; Sugar belonging to Pooideae of Poaceae; Bermuda grass (Cynodon beet (Beta vulgaris ssp. vulgaris var. altissima), Table beet dactylon) and Grass (Zoysia spp.) belonging to Chlori (Beta vulgaris ssp. vulgaris var. vulgaris), and Spinach doideae of Poaceae; Sugarcane (Saccharum officinarum), (Spinacia oleracea) belonging to Amaranthaceae; Buckweat Sorgum (Sorghum bicolor), and Corn (Zea mays) belonging (Fagopyrum esculentum) belonging to Polygonaceae; Kaki to Panicoideae of Poaceae; Banana (Musa spp.) belonging to Persimmon (Diospyros kaki) belonging to Ebenaceae; Tea Musaceae; Myoga (Zingiber mioga) and Ginger (Zingiber plant (Camelia sinensis) belonging to Theaceae; Kiwifruit officinale) belonging to Zingiberaceae; or the like. (Actinidia deliciosa, A. chinensis) belonging to Actinidi aceae; Blueberry (Vaccinium spp.) and Cranberry (Vac 0196) such as Lotus root (Nelumbo nucifera) cinium spp.) belonging to Ericaceae; Coffee plants (Coffea belonging to Nelumbonaceae; Peanut (Arachis hypogaea), spp.) belonging to Rubiaceae; Lemon balm (Melissa offici Chickpea (Cicer arietinum), Lentil (Lens culinaris), Pea nalis), Mint (Mentha spp.), Basil (Ocimum basilicum), Shiso (Pisum sativum), Broad bean (Vicia faba), Soybean (Glycine (Perilla frutescens var. crispa). Perilla frutescens var. frute max), Common bean (Phaseolus vulgaris), Adzuki bean scens, Common Sage (Salvia officinalis), and Thyme (Thy (Vigna angularis), and Cowpea (Vigna unguiculata) belong mus spp.) belonging to Lamiaceae, Sesame (Sesamum indi ing to Fabaceae; Hop (Humulus lupulus) belonging to Can cum) belonging to Pedaliaceae; Olive (Olea europaea) nabaceae: Fig Tree (Ficus carica) and Mulberry (Morus belonging to Oleaceae; Sweet potato (Ipomoea batatas) spp.) belonging to Moraceae; Common jujube (Ziziphus belonging to Convolvulaceae; Tomato (Solanum lycopersi jujuba) belonging to Rhamnaceae; Strawberry (Fragaria) cum), Eggplant (Solanum melongena), Potato (Solanum and Rose (Rosa spp.) belonging to Rosoideae of Rosaceae; tuberosum), Chili pepper (Capsicum annuum), Bell pepper Japanese loquat (Eriobotrya japonica), Apple (Malus (Capsicum annuum var. grossum), and Tobacco (Nicotiana pumila), European Pear (Pyrus communis), and Nashi Pear tabacum) belonging to Solanaceae; Celery (Apium graveO (Pyrus pyrifolia var. culta) belonging to Maloideae of Rosa lens var. dulce), Coriander (Coriandrum sativum), Japanese ceae; Peach (Amygdalus persica), Apricot (Prunus arme honeywort (Cryptotaenia Canadensis Subsp. japonica), Car niaca), Cherry (Prunus avium), Prune (Prunus domestica), rot (Daucus carota Subsp. sativus), Parsley (Petroselium Almond (Prunus dulcis), Japanese Apricot (Prunus mume), crispum), and Italian parsley (Petroselinum neapolitanum) Japanese Plum (Prunus Salicina), Cerasus speciosa, and belonging to Apiaceae; Udo (Aralia cordata) and Aralia Cerasus X vedoensis Somei-yoshino’ belonging to elata belonging to Araliaceae; Artichoke (Cynara scolymus) Prunoideae of Rosaceae; Winter melon (Benincasa hispida), belonging to Carduoideae ; Chicory (Cichorium Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria inty bus) and Lettuce (Lactuca sativa) belonging to Aster Siceraria var. hispida), Lufla (Luffa cylindrica), Pumpkin aceae of Asteraceae, Florists’ daisy (Dendranthema gran (Cucurbita spp.), Zucchini (Cucurbita pepo), Bitter melon diflorum), Crown daisy (Glebionis coronaria), Sunflower (Momordica charantia var. pavel), Muskmelon (Cucumis (Helianthus annuus), Fuki ( japonicus), and Bur melo), Oriental pickling melon (Cucumis melo var. Con dock (Arctium lappa) belonging to Asteraceae of Aster Omon), Oriental melon (Cucumis melo var. makuwa), and Cucumber (Cucumis sativus) belonging to Cucurbitaceae; aceae; or the like. Japanese Chestnut (Castanea crenata) belonging to (0197) The “plants' herein also refers to plants that have Fagaceae; Walnut (Juglans spp.) belonging to Juglandaceae; acquired tolerance to HPPD inhibitors, such as isoxaflutole; Cashew (Anacardium occidentale), Mango (Mangifera ALS inhibitors, such as imazethapyr and thifensulfuron indica), and Pistachio (Pistacia vera) Such as Anacar methyl EPSP synthetase inhibitors, such as glyphosate; diaceae, Japanese pepper (Zanthoxylum piperitum) belong glutamine synthetase inhibitors, such as glufosinate; acetyl ing to Rutoideae of Rutaceae; Bitter orange (Citrus auran CoA carboxylase inhibitors, such as sethoxydim; PPO tium), Lime (Citrus aurantifolia), Hassaku orange (Citrus inhibitors, such as flumioxazin; and herbicides, such as hassaku), Yuzu (Citrus junos), Lemon (Citrus limon), Nat bromoxynil, dicamba, and 2,4-D, by classical breeding Sumikan (Citrus natsudaidai), Grapefruit (Citrus X para methods and gene recombinant technologies. disi), Orange (Citrus sinensis), KaboSu (Citrus sphaero (0198 Examples of the “horticultural plants” that have carpa), Sudachi (Citrus sudachi), Mandarin Orange (Citrus acquired tolerance by classical breeding methods include the tangerina), Satsuma (Citrus unshiu), and Kumquat (For rapeseed, wheat, Sunflower, rice, and corn, which are toler tunella spp.) belonging to Aurantioideae of Rutaceae; ant to ALS-inhibitory imidazolinone herbicides, such as Horseradish (Armoracia rusticana), Mustard (Brassicajun imazethapyr. Such plants are already commercially available cea), Takana (Brassica juncea var. integrifolia), Rapeseed with the product name of Clearfield

0209. These plants further include stacked varieties in esters, such as fatty acid methyl esters, succinic acid dialkyl which two or more useful traits such as classical herbicide esters, glutamic acid dialkyl esters, adipic acid dialkyl traits; herbicide resistant genes; insecticidal pest resistant esters, and phthalic acid dialkyl esters; acid amides, such as genes; anti-pathogenic Substance producing genes; and traits a N-alkyl (C, C, C, or the like) pyrrolidone; and oils, of reformed oil and fat components or traits of enhanced Such as soybean oil, flaxseed oil, canola oil, coconut oil, amino acid components are combined. cottonseed oil, and castor oil; dimethyl Sulfoxide; and water. 0210 Although the composition of the present invention 0213. These solid and liquid carriers may be used alone, can be used as a mixture comprising one or two selected or two or more of them may be used in combination. from the first active ingredient compounds I and one or more 0214) Examples of the surfactant include nonionic sur selected from the second active ingredient compounds II factants, such as a polyoxyethylene alkyl ether, a polyoxy exclusively, usually the composition is mixed with a suitable ethylene alkyl (mono or di)phenyl ether, a polyoxyethylene Solid carrier or a liquid carrier, and if desired, a Surfactant, (mono, di, or tri)Styrylphenyl ether, a polyoxyethylene a penetrant, a spreading agent, a thickener, an antifreezing polyoxypropylene block copolymer, a polyoxyethylene fatty agent, a binder, an anticaking agent, a disintegrant, an acid (mono or di)ester, a Sorbitan fatty acid ester, a poly antifoaming agent, a preservative, a stabilizing agent, and oxyethylene Sorbitan fatty acid ester, a castor oil ethylene the like are further added thereto, so that the composition oxide adduct, acetylene glycol, an acetylene alcohol, an can be provided for uses as a formulation of any dosage ethylene oxide adduct of acetylene glycol, an ethylene oxide form, Such as a soluble concentrate, an emulsifiable con adduct of an acetylene alcohol, and an alkyl glycoside; centrate, a wettable powder, a water soluble powder, water anionic Surfactants, such as an alkyl Sulfuric acid ester salt, dispersible granules, water soluble granules, a suspension an alkylbenzenesulfonate, lignin Sulfonate, an alkyl Sulfo concentrate, a concentrated emulsion, a Suspoemulsion, a Succinate, naphthalenesulfonate, an alkyl naphthalenesul microemulsion, a dustable powder, granules, a tablet, and an fonate, a salt of a formalin condensate of naphthalenesul emulsifiable gel. From the point of view of saving labor and fonate, a salt of a formalin condensate of an alkyl improving safety, the formulation of any dosage form of naphthalenesulfonate; a polyoxyethylene alkyl ether sulfuric above can be provided by including it in a water-soluble acid or phosphoric acid ester salt, a polyoxyethylene (mono packaging body, Such as a water-soluble capsule and a or di)alkyl phenyl ether sulfuric acid or phosphoric acid water-soluble film. ester salt, a polyoxyethylene (mono, di, or tri)Styrylphenyl 0211 Examples of the solid carrier include natural min ether Sulfuric acid or phosphoric acid ester salt, a polycar erals, such as quartZ, calcite, meerschaum, dolomite, chalk, boxylate (for example, a polyacrylate, a polymaleate, a kaolinite, pyrophyllite, sericite, halloysite, metahalloysite, copolymer of maleic acid and olefin, and the like), and kibushi clay, potter's clay, pottery stone, Zeeklite, allophane, polystyrene Sulfonate; cationic Surfactants, such as an alky Silas, mica, talc, bentonite, activated white clay, acid clay, lamine Salt and an alkyl quaternary ammonium salt; ampho pumice Stone, attapulgite, Zeolite, and diatomaceous earth; teric Surfactants, such as amino acid Surfactants and betaine burned natural products, such as burned clay, pearl Surfactants; silicone-based surfactants; and fluorine-based ite, Silas balloon, Vermiculite, attapulgus clay, and burned Surfactants. Although the content of the Surfactant is not diatomaceous earth; inorganic salts, such as magnesium particularly limited, it is preferably within a range of 0.05 carbonate, calcium carbonate, sodium carbonate, sodium part by weight to 20 parts by weight with respect to 100 parts hydrogen carbonate, ammonium Sulfate, sodium sulfate, by weight of the formulation of the present invention. These magnesium sulfate, diammonium hydrogen phosphate, Surfactants may be used alone, or two or more of them may ammonium dihydrogen phosphate, and potassium chloride; be used in combination. Sugars, such as glucose, fructose, Sucrose, and lactose; 0215 Next, mixing examples of formulations in which polysaccharides, such as starch, powder cellulose, and dex the composition of the present invention is used will be trin; organic Substances, such as urea, urea derivative, ben shown. However, mixing examples of the present invention Zoic acid, and salts of benzoic acid; plants, such as wood are not limited thereto. Note that, in the mixing examples powder, cork powder, corn rachises, walnut shells, and below, “part(s) refers to part(s) by weight, and “active tobacco stems; fly ashes; white carbon (such as aqueous ingredient compound is a collective term referring to the synthetic silica, anhydrous synthetic silica, and aqueous first active ingredient compound I and the second active synthetic silicate); and fertilizers. ingredient compound II of the composition of the present 0212. Examples of the liquid carrier include aromatic invention. hydrocarbons. Such as Xylene, an alkyl (Co., Co, or the like) 0216 Wettable Powder benzene, phenylxylyl ethane, and an alkyl (C, C, or the like) naphthalene; aliphatic hydrocarbons, such as a machine Active ingredient compound 0.1 part to 80 parts oil, normal paraffin, isoparaffin, and naphthene; a mixture of Solid carrier 5 parts to 98.9 parts an aromatic hydrocarbon and an aliphatic hydrocarbon, Such Surfactant 1 part to 10 parts as kerosene; alcohols, such as ethanol, isopropanol (2-pro Others O part to 5 parts panol), cyclohexanol, phenoxyethanol, and benzyl alcohol; polyalcohols, such as ethylene glycol, propylene glycol, 0217 Examples of “others' include an anticalking agent diethylene glycol, hexylene glycol, polyethylene glycols, and a stabilizing agent. and polypropylene glycols; ethers, such as propyl celloSolve, butyl celloSolve, phenyl cellosolve, propylene glycol 0218 Emulsifiable Concentrate monomethyl ether, propylene glycol monoethyl ether, pro pylene glycol monopropyl ether, propylene glycol monobu Active ingredient compound 0.1 part to 30 parts tyl ether, and propylene glycol monophenyl ether, ketones, Liquid carrier 45 parts to 95 parts Such as acetophenone, cyclohexanone, and Y-butyrolactone; US 2017/O 135347 A1 May 18, 2017 20

-continued Mixing Example 1 Wettable Powder Surfactant 4.9 parts to 15 parts 0232 Others O part to 10 parts Compound (1) 10 parts Compound No. mu 10 parts 0219. Examples of “others' include a spreading agent Pyrophyllite 76 parts and a stabilizing agent. SORPOL SO39 2 parts (a mixture of a nonionic Surfactant and an 0220 Suspension Concentrate anionic Surfactant: the name of the product of TOHO Chemical Industry Co., Ltd.) Carplex #8OD 2 parts Active ingredient compound 0.1 part to 70 parts (synthetic hydrous silicate: the name of Liquid carrier 15 parts to 98.89 parts the product of Shionogi & Co., Ltd.) Surfactant 1 part to 12 parts Others 0.01 part to 30 parts 0233. These materials are uniformly mixed and pulver ized to prepare a wettable powder. 0221 Examples of “others' include an antifreezing agent and a thickener. Mixing Example 2 Emulsifiable Concentrate 0222 Water Dispersible Granule 0234

Active ingredient compound 0.1 part to 90 parts Compound (1) 3 parts Solid carrier O part to 98.9 parts Compound No. nr 2 parts Surfactant 1 part to 20 parts Xylene 75 parts Others O part to 10 parts N-methylpyrrollidone 15 parts SORPOL 268O 5 parts (a mixture of a nonionic Surfactant and 0223 Examples of “others’ include a binder and a sta an anionic Surfactant: the name of the bilizing agent. product of TOHO Chemical Industry Co., Ltd.) 0224 Soluble Concentrate 0235. These materials are uniformly mixed to prepare an emulsifiable concentrate. Active ingredient compound 0.01 part to 70 parts Liquid carrier 20 parts to 99.99 parts Mixing Example 3 Suspension Concentrate Others O part to 10 parts 0236

0225. Examples of “others' include an antifreezing agent Compound (1) 15 parts and a spreading agent. Compound No. no 10 parts AGRISOLS-710 10 parts 0226 Granule (nonionic Surfactant: the name of the product of Kao Corporation) Lunox 1000C 0.5 part Active ingredient compound 0.01 part to 80 parts (anionic Surfactant: the name of Solid carrier 10 parts to 99.99 parts the product of TOHO Chemical Industry Co., Ltd.) Others O part to 10 parts Xanthan gum 0.2 part Water 64.3 parts

0227 Examples of “others’ include a binder and a sta 0237. These materials are uniformly mixed, and then wet bilizing agent. milled to prepare a suspension concentrate. 0228. Dustable Powder Mixing Example 4 Water Dispersible Granule Active ingredient compound 0.01 part to 30 parts 0238 Solid carrier 65 parts to 99.99 parts Others O part to 5 parts Compound (1) 40 parts Compound No. ny 35 parts 0229. Examples of “others' include an anti drift agent HITENOLNE-15 5 parts (anionic Surfactant: the name of and a stabilizing agent. the product of DKS Co. Ltd.) 0230. Next, specific examples of the agrochemical for WANILLEXN 10 parts (anionic Surfactant: the name of mulation containing the composition of the present inven the product of Nippon Paper Industries Co., Ltd.) tion as the active ingredient will be shown; however, the Carplex #8OD 10 parts present invention is not limited thereto. (synthetic hydrous silicate: the name of the product of Shionogi & Co., Ltd.) 0231. Note that, “part(s) in the mixing examples below refers to part(s) by weight. US 2017/O 135347 A1 May 18, 2017

0239. These materials are uniformly mixed and pulver nyl)-5-trifluoromethyl-4,5-dihydroisoxazole (2-1) that was ized. After a small amount of water is added thereto, the synthesized according to the method described in WO2010/ mixture is stirred. Then, the mixture is granulated with an 005048, 1.24 g (7.95 mmol) of 2-amino-N-(2.2.2-trifluoro extrusion granulator, and is dried to obtain water dispersible ethyl)acetamide, 1.1 g (7.95 mmol) of potassium carbonate, granules. 41.0 mg (0.099 mmol) of 1,3-bis(diphenylphosphino)pro pane, 0.14 g (0.033 mmol) of 5% by mass palladium-carbon Mixing Example 5 Granule (50% aqueous), and 30 ml of 1,2-dimethoxyethane were placed. After the reaction vessel was purged with nitrogen, 0240 then with carbon monoxide, the reaction vessel was filled with the carbon monoxide at 1.0 MPa. The temperature was Compound (1) 3 parts raised to 105° C., and a reaction was performed for 5 hours Compound No. nx 2 parts as stirred at the same temperature. During the reaction, the Bentonite 50 parts pressure inside was increased to 1.3 MPa at most. After that, Talc 45 parts the reaction vessel was cooled to room temperature, the pressure inside of the vessel was reduced to atmospheric 0241 These materials are uniformly mixed and pulver pressure, and the reaction vessel was purged with nitrogen. ized. After a small amount of water is added thereto, the Insoluble matter in the reaction solution was filtered off by mixture is stirred. Then, the mixture is granulated with an celite filtration, and the celite was washed with ethyl acetate extrusion granulator, and is dried to obtain granules. and water. The obtained filtrate was made to be acidic by adding concentrated hydrochloric acid. After an aqueous Mixing Example 6 Dustable Powder phase was separated, an organic phase was washed with saline. The organic phase was dried with anhydrous mag 0242 nesium sulfate. After filtering off, a solvent was removed by vacuum distillation. The obtained residue was crystallized Compound (1) 2 parts with ethyl acetate/hexane-3/18 (ml) to obtain 2.54 g (4.57 Compound No. nb 1 parts mmol) of the target material as a light yellow solid. Carplex #8OD 0.5 part (white carbon: the name of the product of Shionogi & Co., Ltd.) Synthesis Example 2 Manufacture of Compound Kaolinite 95 parts (2) Diisopropyl phosphate 1.5 parts Synthesis Example 2-1: Synthesis of 4-5-(3,5-di 0243 These materials are uniformly mixed and pulver chlorophenyl)-5-trifluoromethyl-4,5-dihydroisox ized to prepare a dustable powder. azole-3-yl)-2-methylbenzamide 0244. At the time of use, the wettable powder, emulsifi able concentrate, flowable agent, and water dispersible gran 0248. To a reaction vessel equipped with a Dean-Stark ules are diluted to 50 to 20,000-fold with water in order to apparatus whose trap was filled with toluene, 10.0 g of spray 0.005 kg to 50 kg of the active ingredient per 1 hectare 4-acetyl-2-methylbenzamide, 143.7 g of toluene, and 1.9 g, (ha). of water were added in this order, and the mixture was 0245. In the present invention, the composition of the heated at 85°C. as stirred for 1 hour. After the stirring was present invention, which contains the first active ingredient completed, 13.9 g of 3',5'-dichloro-2.2.2-trifluoromethyl compound I and the second active ingredient compound II, acetophenone and 2.8 g of a 5% by weight tetrabutyl can be made as a formulation for uses, as described above. ammonium hydroxide aqueous solution were added thereto, However, a chemical containing the first active ingredient and the mixture was heated at 85°C. as stirred for 1 hour. compound I or the second active ingredient compound II as After the stirring was completed, the reaction mixture was an active ingredient can be prepared separately, and then continued to be stirred at 65° C. for 3 hours. After the stirring these chemicals can be used at the same time or at different was completed, the pressure was reduced to 20 kPa, and the times that are close to each other, in order to obtain excellent mixture was refluxed for 12 hours to be azeotropically synergistic control effects. Note that, when these chemicals dehydrated. After the stirring was completed, the mixture are used at different times that are close to each other, the was cooled to 0°C., and 2.5g of 1,8-diazabicyclo5.4.0- second chemical is preferably sprayed after the first sprayed 7-undecene, 9.5 g of 1,1,3,3-tetramethylguanidine, and 18.3 chemical is sufficiently dried. However, it may vary depend g of a 25% by weight hydroxyamine aqueous solution were ing on control methods, diseases to be controlled, and the added thereto. After the addition was completed, the reaction like. mixture was stirred for 21 hours at the same temperature. After the stirring was completed, 8.0 g of a 20% by weight EXAMPLES hydrochloric acid aqueous Solution and 63.1 g of 2-propanol were added thereto. The obtained reaction mixture was 0246 Hereinafter, a method for manufacturing Com washed three times with 53.4 g of water, and then 50.4 g of pound (1) and Compound (2) used in the composition of the the solvent was removed by vacuum distillation. 28.8g of present invention will be specifically explained. toluene was further added thereto, and the mixture was heated to 100° C. to dissolve slurry, and then cooled to 0°C. Synthesis Example 1 Manufacture of Compound to be crystallized. After the obtained slurry was filtrated, the (1) obtained crystal was washed with 19.2 g of toluene that was 0247. In a 100 ml pressure reaction vessel, 3.00 g (6.62 cooled to 0° C. The obtained solid was vacuum-dried to mmol) of 3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophe obtain 16.7 g of the target material. The obtained solid was US 2017/O 135347 A1 May 18, 2017 22 analyzed by an internal reference analysis method using 0259 X: an observed value at an X concentration of HPLC, and the result showed that the purity was 98.3%. Chemical A (the percentage of dead insects) 0249. The conditions of the analysis using HPLC are shown below. 0260 Y: an observed value at a y concentration of (0250 Column: Inertsil Ph-3 50 mm 4.6 mm (b 3 um Chemical B (the percentage of dead insects) (manufactured by GL Sciences Inc.) 0261 E: the percentage of dead insects expected at the 0251 Flow rate: 1 mL/min time of a mixed treatment with Chemical A and Chemical B. 0252 Eluent: acetonitrile/waterfacetic acid=800/1, 200/1.2 (volume ratio) 0262 The obtained results were analyzed as follows. If 0253 Detection: UV 220 nm. the observed value was larger than the expected value, there 0254 Internal standard material: 4-t-butylbiphenyl was a synergistic effect; if the expected value was larger than the observed value, there was an antagonist effect; and if the Synthesis Example 2-2: Synthesis of Compound (2) observed value and the expected value were same, there was 0255 2.00 g of 4-5-(3,5-dichlorophenyl)-5-trifluorom an additive effect. The combinations that showed synergistic ethyl-4,5-dihydroisoxazole-3-yl)-2-methylbenzamide that effects are listed in Tables 3 to 8 below. was obtained in Synthesis Example 2-1, 4.26 g of ortho formic acid triethyl, and 10 ml of a 0.60 g methoxyamine TABLE 3 hydrochloride toluene solution were stirred at 35° C. for 24 Percentage of Percentage of hours. After the stirring was completed, 10 ml of toluene was Concentration Dead Insect (%) Dead Insect (%) added to the reaction solution. After the addition was com Active ingredient (ppm) Observed Value Expected Value pleted, the reaction solution was heated to 60° C. to 65° C. Compound (1) O.O17 28.6 and washed with water (4 milx3 times). 10 ml of toluene was Compound (2) O.O17 35.7 removed from the obtained toluene solution by vacuum Compound aa O.083 21.4 Compoundar O.S 35.7 distillation. After the removal by vacuum distillation, the Compound (1) + 0.017 + 0.083 85.7 43.9 toluene solution was cooled from about 70° C. at a rate of Compound aa about 20° C./hour. After crystals were generated in the Compound (1) + 0.017 + 0.5 78.6 54.1 toluene solution, the solution was stirred at 0°C. to 5° C. for Compoundar 3 hours. After the stirring was completed, the deposited Compound (2) + 0.017 + 0.083 85.7 49.5 Compound aa crystals were separated by vacuum filtration, and the Compound (2) + 0.017 + 0.5 71.4 58.7 obtained crystals were vacuum-dried to obtain 1.92 g of the Compoundar target material as white crystals. Non-treated O O Test Example 0256 Next, the usefulness of the present invention will TABLE 4 be specifically explained in the Efficacy Test Examples below. However, the present invention is not limited thereto. Percentage of Percentage of Concentration Dead Insect (%) Dead Insect (%) Test Example 1 Efficacy Test for Common Active ingredient (ppm) Observed Value Expected Value Cutworm Compound (2) O.O2S 35.7 Compound em 32 6O.O 0257 Each of Compound (1) or Compound (2) and the Compound (2) + O.O25 - 32 92.9 74.3 compounds listed in Table 1 was formulated into a 10% Compound em emulsifiable concentrate (some compound was formulated Non-treated O O into a 25% wettable powder). The formulations were diluted with water containing a spreading agent to prepare chemical Solutions of given concentrations. Cabbage leaves were TABLE 5 dipped in the chemical solutions for 10 seconds. The dipped cabbage leaves were transferred on filter papers placed in 7 Percentage of Percentage of cm petri dishes with one leaf per one petri dish, and the Concentration Dead Insect (%) Dead Insect (%) leaves were air dried. After the air drying was completed, the Active ingredient (ppm) Observed Value Expected Value Compound (2) O.O2S 35.7 seven third instar larvae of common cutworms were placed Compound el 4.4 78.6 in each petri dish and then the petri dishes were placed in an Compound (2) + O.O25 - 32 100 86.2 incubator at 25°C. Six days after the treatment, the numbers Compound el of dead larvae were checked, and the percentages of dead Non-treated O O insects were calculated according to the calculating equation below. Note that the tests were conducted in duplicate. The percentage of dead insects (%)=the number of TABLE 6 dead insects the number of tested insectsx100 Percentage of Percentage of 0258 To each concentration of chemical solutions, the Concentration Dead Insect (%) Dead Insect (%) synergistic effect was calculated from the percentage of dead Active ingredient (ppm) Observed Value Expected Value insects by using Colby's method (Colby S. R. 1976, Weeds Compound (2) O.O2S 35.7 15, 20-22). The calculation method was as follows. Compound dc 1.7 53.8 US 2017/O 135347 A1 May 18, 2017 23

TABLE 6-continued 0267 E: the percentage of dead insects expected at the time of a mixed treatment with Chemical A and Chemical B. Percentage of Percentage of 0268. The obtained results were analyzed as follows. If Concentration Dead Insect (%) Dead Insect (%) the observed value was larger than the expected value, there Active ingredient (ppm) Observed Value Expected Value was a synergistic effect; if the expected value was larger than Compound (2) + O.O25 - 1.7 83.3 70.3 the observed value, there was an antagonist effect; and if the Compound dc observed value and the expected value were same, there was Non-treated O O an additive effect. The combinations that showed synergistic effects are listed in Table 9 below.

TABLE 7 TABLE 9 Percentage of Percentage of Percentage of Percentage of Concentration Dead Insect (%) Dead Insect (%) Concentration Dead Insect (%) Dead Insect (%) Active ingredient (ppm) Observed Value Expected Value Active ingredient (ppm) Observed Value Expected Value Compound (2) O.OOS 14.3 Compound (1) O.12S 28.6 Compoundam O.17 7.7 Compound (2) O.12S 35.7 Compound (2) + O.005 - 0.17 61.5 20.9 Compound all O.25 42.9 Compoundam Compound ca. O.O2S 35.7 Non-treated O O Compound (1) + 0.125 + 0.25 92.9 59.2 Compound all Compound (1) + 0.125 + 0.025 85.7 54.1 Compound ca. TABLE 8 Compound (2) + 0.125 + 0.25 85.7 6.3.3 Compound all Percentage of Percentage of Compound (2) + 0.125 + 0.025 100 58.7 Concentration Dead Insect (%) Dead Insect (%) Compound ca. Active ingredient (ppm) Observed Value Expected Value Non-treated O O Compound (2) O.OOS 14.3 Compound ey 1.7 64.3 Compound (2) + O.005 - 0.17 846 69.4 Test Example 3 Efficacy Test for Sweetpotato Compound ey Whitefly Biotype B Non-treated O O 0269. Each of Compound (1) or Compound (2) and the compounds listed in Table 1 was formulated into a 10% Test Example 2 Efficacy Test for Cotton emulsifiable concentrate. The formulations were diluted with water to prepare chemical solutions of given concen Bollworm trations. A styrol cup (having the diameter of the lid of 7.5 0263. Each of Compound (1) or Compound (2) and the cm, and the height of 4 cm) was filled with tap water, and a compounds listed in Table 1 was formulated into a 10% lid having a hole in its center was placed on the Styrol cup, emulsifiable concentrate (some compound was formulated and a filter paper was placed on the lid to absorb tap water. into a 25% wettable powder). The formulations were diluted An absorbent cotton (5 cmx5 cm) wetted with tap water was with water containing a spreading agent to prepare chemical placed on the filter paper, and a leaf disk (having the Solutions of given concentrations. Cabbage leaves were diameter of 3 cm) made of a common bean leaf was placed dipped in the chemical solutions for 10 seconds. The dipped on the absorbent cotton. Each of the test containers was cabbage leaves were transferred on filter papers placed in 7 treated with a spray Solution as was uniformly sprayed by cm petri dishes with one leaf per one petri dish, and the using a spraying apparatus (2.5 ml/cup). The 20 Sweetpotato leaves were air dried. After the air drying was completed, the whitefly adult insects were placed on the leaf disk, and a seven fourth instar larvae of cotton bollworms were placed mesh lid was placed over the container to prevent escape of in each petri dish, and then, the petri dishes were placed in the insects. Examinations were conducted 5 days after an incubator at 25° C. Six days after the treatment, the spraying, and the percentages of dead insects were calcu numbers of dead larvae were checked, and the percentages lated according to the calculating equation below. Note that of dead insects were calculated according to the calculating the tests were conducted in duplicate. equation below. Note that the tests were conducted in The percentage of dead insects (%)=the number of duplicate. dead insects the number of tested insectsx100 The percentage of dead insects (%)=the number of To each concentration of chemical Solutions, the Synergistic dead insects the number of tested insectsx100 effect was calculated from the percentage of dead insects by 0264. To each concentration of chemical solutions, the using Colby's method (Colby S.R. 1976, Weeds 15, 20-22). synergistic effect was calculated from the percentage of dead The calculation method was as follows. insects by using Colby's method (Colby S. R. 1976, Weeds 15, 20-22). The calculation method was as follows. 0270 X: an observed value at an X concentration of Chemical A (the percentage of dead insects) 0265 X: an observed value at an X concentration of 0271 Y: an observed value at a y concentration of Chemical A (the percentage of dead insects) Chemical B (the percentage of dead insects) 0266 Y: an observed value at a y concentration of 0272 E: the percentage of dead insects expected at the Chemical B (the percentage of dead insects) time of a mixed treatment with Chemical A and Chemical B. US 2017/O 135347 A1 May 18, 2017 24

0273. The obtained results were analyzed as follows. If TABLE 11 the observed value was larger than the expected value, there was a synergistic effect; if the expected value was larger than Percentage of Percentage of the observed value, there was an antagonist effect; and if the Concentration Dead Insect (%) Dead Insect (%) observed value and the expected value were same, there was Active ingredient (ppm) Observed Value Expected Value an additive effect. The combinations that showed synergistic Compound (2) 5 42.1 effects are listed in Table 10 below. Compound bX 2.5 S2.6 Compound (2) + 5 - 2.5 84.2 72.6 Compound bX TABLE 10 Non-treated O 15 Percentage of Percentage of Concentration Dead Insect (%) Dead Insect (%) Active ingredient (ppm) Observed Value Expected Value Test Example 5 Efficacy Test for Western Flower Compound (2) 5 36.6 Thrips Larva Compound ci 25 4.O.S Compound (2) + 5 - 25 82.1 62.3 0280 A styrol cup (having the diameter of the lid of 7.5 Compound ci cm, and the height of 4 cm) was filled with tap water, and a Non-treated O 15.8 lid having a hole in its center was placed on the Styrol cup, and a leaf disk (having the diameter of 1.7 cm) made of a common bean leaf was placed on the lid. Suitable amounts Test Example 4 Efficacy Test for Melon Thrips of eggs of Western flower thrips were placed on the leaf disk, Female Adult Insect and were controlled in a thermostatic chamber for 24 hours to be hatched. Each of Compound (1) or Compound (2) and 0274 Each of Compound (1) or Compound (2) and the the compounds listed in Table 1 was formulated into a 10% compounds listed in Table 1 was formulated into a 10% emulsifiable concentrate. The formulations were diluted emulsifiable concentrate. The formulations were diluted with water to prepare chemical solutions of given concen with water to prepare chemical solutions of given concen trations. Each of the test containers was treated with a spray trations. A styrol cup (having the diameter of the lid of 7.5 Solution as was uniformly sprayed by using a spraying cm, and the height of 4 cm) was filled with tap water, and a apparatus (2.5 ml/cup). Examinations were conducted 1 day lid having a hole in its center was placed on the styrol cup, after spraying, and the percentages of dead insects were and a filter paper was placed on the lid to absorb tap water. calculated according to the calculating equation below. Note An absorbent cotton (5 cmx5 cm) wetted with tap water was that the tests were conducted in duplicate. placed on the filter paper, and a leaf disk (having the The percentage of dead insects (%)=the number of diameter of 1.7 cm) made of a cucumber leaf was placed on dead insects the number of tested insectsx100 the absorbent cotton. The ten melon thrips female adult insects were placed on the leaf disk. Each of the test 0281. To each concentration of chemical solutions, the containers was treated with a spray solution as was uni synergistic effect was calculated from the percentage of dead formly sprayed by using a spraying apparatus (2.5 ml/cup). insects by using Colby's method (Colby S. R. 1976, Weeds Examinations were conducted 2 days after spraying, and the 15, 20-22). The calculation method was as follows. percentages of dead insects were calculated according to the E=X-Y-XY/100 calculating equation below. Note that the tests were con 0282 X: an observed value at an X concentration of ducted in duplicate. Chemical A (the percentage of dead insects) The percentage of dead insects (%)=the number of 0283 Y: an observed value at a y concentration of dead insects the number of tested insectsx100 Chemical B (the percentage of dead insects) 0275 To each concentration of chemical solutions, the 0284 E: the percentage of dead insects expected at the synergistic effect was calculated from the percentage of dead time of a mixed treatment with Chemical A and Chemical B. insects by using Colby's method (Colby S. R. 1976, Weeds 0285. The obtained results were analyzed as follows. If 15, 20-22). The calculation method was as follows. the observed value was larger than the expected value, there was a synergistic effect; if the expected value was larger than the observed value, there was an antagonist effect; and if the 0276 X: an observed value at an X concentration of observed value and the expected value were same, there was Chemical A (the percentage of dead insects) an additive effect. The combinations that showed synergistic 0277 Y: an observed value at a y concentration of effects are listed in Table 12 below. Chemical B (the percentage of dead insects) 0278 E: the percentage of dead insects expected at the TABLE 12 time of a mixed treatment with Chemical A and Chemical B. Percentage of Percentage of Concentration Dead Insect (%) Dead Insect (%) 0279. The obtained results were analyzed as follows. If Active ingredient (ppm) Observed Value Expected Value the observed value was larger than the expected value, there Compound (2) 1 29.5 was a synergistic effect; if the expected value was larger than Compound q. 2O 8.5 the observed value, there was an antagonist effect; and if the Compound ce 2O 27.2 observed value and the expected value were same, there was Compound (2) + 1 + 20 56.6 35.4 an additive effect. The combinations that showed synergistic Compound q. effects are listed in Table 11 below. US 2017/O 135347 A1 May 18, 2017 25

TABLE 12-continued 2) one or more active compound(s) II selected from active ingredient groups A to R below: Percentage of Percentage of active ingredient group A: benalaxyl, benalaxyl-M, fural Concentration Dead Insect (%) Dead Insect (%) axyl, metalaxyl, metalaxyl-M, ofurace, oxadixyl, Active ingredient (ppm) Observed Value Expected Value bupirimate, ethirimol, and hymexaZol; Compound (2) + 1 + 20 72.0 48.7 active ingredient group B: benomyl, carbendazim, Compound ce fuberidazole, thiabendazole, thiophanate-methyl, Non-treated O 8.0 diethofencarb, ethaboxam, Zoxamide, pencycuron, and fluopicolide; active ingredient group C: diflumetorim, benodanil, ben Reference Example 1 Efficacy Test for Varroa Zovindiflupyr, bixafen, boscalid, carboxin, fenfuram, Mite fluopyram, flutolanil, fluxapyroxad, furametpyr, isofe 0286 The Compound (1) or Compound (2) was adjusted tamid, isopyrazam, mepronil, oxycarboxin, penflufen, to a given concentration with acetone. After the adjustment, penthiopyrad, sedaxane, thifluZamide, azoxystrobin, 300 ul of each of the prepared solutions was poured into a coumoxystrobin, dimoxystrobin, enestrobin, enoxas 20 ml screw bottle. The solvent was volatilized as the inner trobin, famoxadone, fenamidone, fenaminstrobin, surface of the bottle was uniformly coated with the solution, flufenoxystrobin, fluoxastrobin, kresoxim-methyl, and then the bottle was stored in a cool and dark place mandestrobin, metominostrobin, orysastrobin, picox overnight. To obtain varroa mites, a blood comb was taken yStrobin, pyraclostrobin, pyrametostrobin, pyraox out from a beehive of honey bees on the day before placing yStrobin, pyribencarb-methyl, pyriminostrobin, tric of mites, and pupae having varroa mites were taken and lopyricab, trifloxystrobin, amisulbrom, cyaZofamid, placed in a petri dish. The petri dish was stored in an dinocap, fluazinam, meptylidinocap, fentin, tributyltin incubator at 34° C. overnight under the total darkness oxide, silthiofam, and ametoctradin; condition, and then only Surviving varroa mites were col active ingredient group D: cyprodinil, mepanipyrim, lected. The collected varroa mites were placed in each of the pyrimethanil, blasticidin-S, and kasugamycin; screw bottles that were treated with the above-described active ingredient group E: produinazid, quinoxyfen, fen chemicals, and the screw bottles were closed with caps. piclonil, fludioxonil, chloZolinate, iprodione, procymi After three hours, the pupae of honeybees were placed in the done, and VincloZolin; screw bottles; the screw bottles were closed with caps again, active ingredient group F: edifenphos, iprobenfos, isopro and were stored in an incubator at 34° C. under the total thiolane, pyrazophos, biphenyl, chloroneb, dicloran, darkness condition. The number of dead insects 24 hours etridiazole, quintoZene, tecnaZene, tolclofoS-methyl, after placing was checked, and the percentages of dead propamocarb hydrochloride, and Bacillus subtilis, insects were calculated according to the calculating equation active ingredient group G: azaconazole, bitertanol, bro below. The results are shown in Table 13. Note that the tests muconazole, climbazole, cyproconazole, diclobutraZol, were conducted in quadruplicate of three in one plot. difenoconazole, diniconazole, diniconazole-M, epoxi The percentage of dead insects (%)=the number of conazole, etaconazole, fenarimol, fenbuconazole, flu dead insects the number of tested insectsx100 otrimazole, fluquinconazole, flusilaZole, flutriafol, fur conazole, hexaconazole, imazalil, imibenconazole, ipconazole, metconazole, myclobutanil, nuarimol, TABLE 13 Oxpoconazole fumarate, pefurazoate, penconazole, Concentration Percentage of prochloraz, propiconazole, prothioconazole, pyrifenox, Active ingredient (ug tube) Dead Insect (%) pyrisoxazole, Simeconazole, tebuconazole, tetracon Compound No. (1) 1OO 100 azole, triadimefon, triadimenol, triflumizole, triforine, Compound No. (2) 1OO 100 triticonazole, aldimorph, dodemorph-acetate, fenpropi Non-treated O O din, fempropimorph, piperalin, Spiroxamine, tride morph, fenhexamid, and fenpyraZamine; active ingredient group H: validamycin, polyoxins, poly OXorin-D, benthiavalicarb-isopropyl, dimethomorph, INDUSTRIAL APPLICABILITY flumorph, iprovalicarb, mandipropamid, pyrimorph, 0287. The composition of the present invention and the and valifenalate; method of the present invention can be used for controlling active ingredient group I: phthalide, pyroquilon, tricycla various pests. Zole, carpropamid, diclocymet, and fenoxanil; 1. An insecticidal, miticidal, nematicidal, molluscicidal, active ingredient group J. acibenzolar-S-methyl, probena microbicidal, or bactericidal composition comprising at Zole, isotianil, tiadinil, and laminarin; least two types of active compounds with amounts that active ingredient group K: bordeaux mixture, cheshunt are synergistically active, wherein the two types of mixture, basic copper carbonate, copper hydroxide, active compounds include: copper naphthenate, copper oleate, copper oxychloride, 1) one or two active compound(s) I containing 4-5-(3.5- copper Sulfate, basic copper Sulfate, oxine copper, dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isox calcium polysulfide, Sulfur, amobam, ferbam, manco azole-3-yl)-2-methyl-N-(2-oxo-2-(2.2.2-trifluoro Zeb, maneb, metiram, polycarbamate, propineb, thiram, ethyl)aminoethylbenzamide O (Z)-4-5-(3.5- Ziram, captan, folpet, chlorothalonil, dichlofluanid, dichlorophenyl)-5-trifluoromethyl-4,5- tolylfluanid, guaZatine, iminoctadine-albesilate, imi dihydroisoxazole-3-yl)-N-(methoxyiminomethyl)-2- noctadine-triacetate, anilazine, dithianon, chinomethio methylbenzamide; and nat, and fluoroimide; US 2017/0135347 A1 May 18, 2017 26

active ingredient group L: cyflufenamid, cymoxaniil, active ingredient group 0: cadusafos, dichlofenthion, diclomezine, dodine, ferimzone, flusulfamide, flutianil, ethoprophos, fenamiphos, fluensulfone, fosthiazate, fosetyl-aluminium, metrafenone, oxathiapiprolin, fosthietan, imicyafos, isamidofos, isazofos, methyl bro picarbutraZox, pyriofenone, tebufloquin, tolprocarb, mide, methyl isothiocyanate, oxamyl, sodium azide, triazoxide, potassium hydrogen carbonate, sodium thiaxazafen, BYI-1921 (test name), and MAI-080 15 hydrogen carbonate, Chinese mushroom mycelium (test name); extract, Chinese mushroom carpophore extract, BCF active ingredient group P: acriflavine, albendazole, 082 (test name), NNF-0721 (test name), and ZF-9646 atovaguone, azithromycin, bithionol, bromofenofos, (test name); active ingredient group M: abamectin, cambendazole, carnidazole, chloroquine, claZuril, clin acephate, acetamiprid, afidopyropen, afoxolaner, damycin hydrochloride, clorsulon, closantel, couma alanycarb, aldicarb, allethrin, azamethiphos, azinphos phos, cymiazol, dichlorophen, diethylcarbamazine, ethyl, azinphos-methyl, Bacillus thuringiensis, bendio diminaZene, disophenol, dithiazanine iodide, doxycy carb, benfluthrin, benfuracarb, bensultap, bifenthrin, cline hydrochloride, doramectin, emodepside, epri bioallethrin, bioresmethrin, bistrifluron, buprofezin, nomectin, febantel, fenbendazole, flubendazole, fura butocarboxim, carbaryl, carbofuran, carbosulfan, car Zolidone, glycalpyramide, imidocarb, ivermectin, tap, chlorantraniliprole, chlorethoxyfos, chlorfenapyr, levamisole, mebendazole, mefloquine, melarsamine chlorfenvinphos, chlorfluazuron, chlormephos, chlo hydrochloride, metronidazole, metyridine, milbemycin rpyrifos, chlorpyrifos-methyl, chromafenozide, cloth Oxime, monepantel, morantel tartrate, moxidectin, ianidin, cyanophos, cyantraniliprole, cyclaniliprole, nicarbazin, niclosamide, nitroscanate, nitroxynil, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, omphalotin, oxantel pamoate, oxantel tartrate, Oxfen gamma-cyhalothrin, lambda-cyhalothrin, cyper daZolee, oxibendazole, oxyclozanide, pamaquine, phe methrin, alpha-cypermethrin, beta-cypermethrin, Zeta nothiazine, piperazine adipate, piperazine citrate, pip cypermethrin, cyphenothrin, cyromazine, deltamethrin, erazine phosphate, PNU-97333, PNU-141962, diafenthiuron, diazinon, dichlorvos, diflubenzuron, praziquantel, primaquine, propetamphos, propoxur. dimethoate, dimethylvinphos, dinotefuran, diofenolan, pyrantel pamoate, pyrimethamine, santonin, selamec disulfoton, emamectin-benzoate, empenthrin, endosul tin, sulfadimethoxine, sulfadoxine, sulfamerazine, sul fan, alpha-endosulfan, EPN, esfenvalerate, ethiofen famonomethoxine, sulfamoildapsone, thiabendazole, carb, ethiprole, etofemprox, etrimfos, fenitrothion, tinidazole, toltraZuril, tribromsalan, and triclabenda fenobucarb, fenoxycarb, fenthion, fenvalerate, fipronil, Zole; flometoquin, flonicamid, fluaZuron, flubendiamide, flu active ingredient group Q: ketoconazole and miconazole cycloxuron, flucythrinate, flufenerim, flufenoxuron, nitrate; and flufiprole, fluhexafon, flumethrin, flupyradifurone, flu active ingredient group R: amoxicillin, ampicillin, valinate, tau-fluvalinate, fonofos, furathiocarb, halofe bethoxazin, bithionol, bronopol, cefapirin, cefazolin, nozide, heptafluthrin, hexaflumuron, hydramethylnon, cefauinome, ceftiofur, chlortetracycline, clavulanic imidacloprid, imiprothrin, indoxacarb, indoxacarb-MP. acid, danofloxacin, difloxacin, dinitolmide, enrofloxa isoprocarb, isoxathion, lepimectin, lufenuron, mala cin, florfenicol, lincomycin, lomefloxacin, marbofloxa thion, meperfluthrin, metaflumizone, metaldehyde, cin, miloxacin, mirosamycin, nitrapyrin, norfloxacin, methacrifos, methamidophos, methidathion, octhillinone, ofloxacin, orbifloxacin, oxolinic acid, methomyl, methoprene, methoxychlor, methoxyfenoz Oxytetracycline, penicillin, streptomycin, thiampheni ide, metofluthrin, muscalure, nitenpyram, novaluron, col, tiamulin fumarate, tilmicosin phosphate, acetylis noviflumuron, omethoate, Oxydemeton-methyl, para ovaleryltylosin, tylosin phosphate, tulathromycin, val thion-methyl, permethrin, phenothrin, phenthoate, nemulin, calcinated shell calcium (calcium oxide), phorate, phosalone, phosmet, phoxim, pirimicarb, genus Talaromyces, genus Trichoderma, and genus pirimiphos-methyl, profenofos, prothiofos, pymetro Coniothyrium. Zine, pyraclofos, pyrethrins, pyridalyl pyrifluquinazon, 2. The insecticidal, miticidal, nematicidal, microbicidal, pyriprole, pyriproxy fen, resmethrin, rotenone, silaflu or bactericidal composition according to claim 1, compris ofen, spinetoram, spinosad, spirotetramat, sulfotep, sul ing the active compound II selected from the active ingre foxaflor, tebufenozide, teflubenzuron, tefluthrin, terbu dients M. fos, tetrachlorvinphos, tetramethrin, d-tetramethrin, 3. The insecticidal, miticidal, nematicidal, microbicidal, tetramethylfluthrin, tetraniliprole, thiacloprid, thiame or bactericidal composition according to claim 2, compris thoxam, thiocyclam, thiodicarb, thiofanox, thiometon, ing the active compound II selected from the active ingre tolfenpyrad, tralomethrin, transfluthrin, triazamate, dient group M consisting of chlorantraniliprole, cyantra trichlorfon, triflumeZopyrim, triflumuron, ME5382 niliprole, flubendiamide, gamma-cyhalothrin, (test name), MIE-1209 (test name), and ZDI2501 (test cyclaniliprole, tetraniliprole, spinosad, spinetoram, metaflu name); mizone, flupyradifurone, flometoquin, bifenthrin, and active ingredient group N. acequinocyl, acrinathrin, flufenoxuron. amidoflumet, amitraz, azocyclotin, benzoximate, 4. The insecticidal, miticidal, nematicidal, microbicidal, bifenazate, bromopropylate, clofentezine, cyenopyra or bactericidal composition according to claim 3, compris fen, cyflumetofen, dicofol, dienochlor, etoxazole, ing the active compound II selected from the active ingre fenaZaquin, fenbutatin oxide, fenothiocarb, fenpropath dient group M consisting of chlorantraniliprole, cyantra rin, fenpyroximate, fluacrypyrim, formetanate, halfen niliprole, flubendiamide, and gamma-cyhalothrin. proX, hexythiazox, milbemectin, propargite, py flubu 5. The insecticidal, miticidal, nematicidal, microbicidal, mide, pyridaben, pyrimidifen, spirodiclofen, or bactericidal composition according to any one of claim 1, spiromesi?en, tebufenpyrad, and NA-89 (test name); wherein the active compound I is 4-5-(3,5-dichlorophenyl)- US 2017/O 135347 A1 May 18, 2017 27

4,5-dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl 10. The insecticidal, miticidal, nematicidal, microbicidal, N-2-oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide. or bactericidal composition according to claim 3, wherein 6. The insecticidal, miticidal, nematicidal, microbicidal, the active compound I is 4-5-(3,5-dichlorophenyl)-4,5- or bactericidal composition according to any one of claim 1, dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl-N-2- wherein the active compound I is (Z)-4-5-(3,5-dichlorophe oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide. 11. The insecticidal, miticidal, nematicidal, microbicidal, nyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl)-N- or bactericidal composition according to claim 4, wherein (methoxyiminomethyl)-2-methylbenzamide. the active compound I is 4-5-(3,5-dichlorophenyl)-4,5- 7. A method for controlling pests and diseases wherein dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl-N-2- treatment is conducted with the one or two active compound oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide. (s) I as claimed in claim 1 and the one or more active 12. The insecticidal, miticidal, nematicidal, microbicidal, compound(s) II as claimed in claim 1 at the same time or at or bactericidal composition according to claim 2, wherein different times that are close to each other. the active compound I is (Z)-4-5-(3,5-dichlorophenyl)-5- 8. A method for controlling pests wherein a treatment is trifluoromethyl-4,5-dihydroisoxazole-3-yl-N-(methoxy conducted with the one or more active compound(s) I as iminomethyl)-2-methylbenzamide. claimed in claim 1 and the one or more active compound(s) 13. The insecticidal, miticidal, nematicidal, microbicidal, II selected from the active ingredient group M consisting of or bactericidal composition according to claim 3, wherein chlorantraniliprole, cyantraniliprole, flubendiamide, the active compound I is (Z)-4-5-(3,5-dichlorophenyl)-5- gamma-cyhalothrin cyclaniliprole, tetraniliprole, tetranil trifluoromethyl-4,5-dihydroisoxazole-3-yl-N-(methoxy prole, spinosad, spinetoram, metaflunizone, flupyradifurone, iminomethyl)-2-methylbenzamide. flometoquin, bifenthrin, and flufenoxuron. 14. The insecticidal, miticidal, nematicidal, microbicidal, 9. The insecticidal, miticidal, nematicidal, microbicidal, or bactericidal composition according to claim 4, wherein or bactericidal composition according to claim 2, wherein the active compound I is (Z)-4-5-(3,5-dichlorophenyl)-5- the active compound I is 4-5-(3,5-dichlorophenyl)-4,5- trifluoromethyl-4,5-dihydroisoxazole-3-yl-N-(methoxy dihydro-5-(trifluoromethyl)isoxazole-3-yl)-2-methyl-N-2- iminomethyl)-2-methylbenzamide. oxo-2-(2.2.2-trifluoroethyl)aminoethylbenzamide. k k k k k