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Peakal: Protons I Have Known and Loved — Fifty Shades of Grey-Market Spectra
PeakAL: Protons I Have Known and Loved — Fifty shades of grey-market spectra Stephen J. Chapman* and Arabo A. Avanes * Correspondence to: Isomer Design, 4103-210 Victoria St, Toronto, ON, M5B 2R3, Canada. E-mail: [email protected] 1H NMR spectra of 28 alleged psychedelic phenylethanamines from 15 grey-market internet vendors across North America and Europe were acquired and compared. Members from each of the principal phenylethanamine families were analyzed: eleven para- substituted 2,5-dimethoxyphenylethanamines (the 2C and 2C-T series); four para-substituted 3,5-dimethoxyphenylethanamines (mescaline analogues); two β-substituted phenylethanamines; and ten N-substituted phenylethanamines with a 2-methoxybenzyl (NBOMe), 2-hydroxybenzyl (NBOH), or 2,3-methylenedioxybenzyl (NBMD) amine moiety. 1H NMR spectra for some of these compounds have not been previously reported to our knowledge. Others have reported on the composition of “mystery pills,” single-dose formulations obtained from retail shops and websites. We believe this is the first published survey of bulk “research chemicals” marketed and sold as such. Only one analyte was unequivocally misrepresented. This collection of experimentally uniform spectra may help forensic and harm-reduction organizations identify these compounds, some of which appear only sporadically. The complete spectra are provided as supplementary data.[1] Keywords: 1H NMR, drug checking, grey markets, research chemicals, phenylethanamines, N-benzyl phenylethanamines, PiHKAL DOI: http://dx.doi.org/10.16889/isomerdesign-1 Published: 1 August 2015 Version: 1.03 “Once you get a serious spectrum collection, Nevertheless, an inherent weakness of grey markets is the the tendency is to push it as far as you can.”1 absence of regulatory oversight. -
Hallucinogens: an Update
National Institute on Drug Abuse RESEARCH MONOGRAPH SERIES Hallucinogens: An Update 146 U.S. Department of Health and Human Services • Public Health Service • National Institutes of Health Hallucinogens: An Update Editors: Geraline C. Lin, Ph.D. National Institute on Drug Abuse Richard A. Glennon, Ph.D. Virginia Commonwealth University NIDA Research Monograph 146 1994 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health National Institute on Drug Abuse 5600 Fishers Lane Rockville, MD 20857 ACKNOWLEDGEMENT This monograph is based on the papers from a technical review on “Hallucinogens: An Update” held on July 13-14, 1992. The review meeting was sponsored by the National Institute on Drug Abuse. COPYRIGHT STATUS The National Institute on Drug Abuse has obtained permission from the copyright holders to reproduce certain previously published material as noted in the text. Further reproduction of this copyrighted material is permitted only as part of a reprinting of the entire publication or chapter. For any other use, the copyright holder’s permission is required. All other material in this volume except quoted passages from copyrighted sources is in the public domain and may be used or reproduced without permission from the Institute or the authors. Citation of the source is appreciated. Opinions expressed in this volume are those of the authors and do not necessarily reflect the opinions or official policy of the National Institute on Drug Abuse or any other part of the U.S. Department of Health and Human Services. The U.S. Government does not endorse or favor any specific commercial product or company. -
Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected]
Florida International University FIU Digital Commons FIU Electronic Theses and Dissertations University Graduate School 4-25-2018 Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances Joshua Zolton Seither [email protected] DOI: 10.25148/etd.FIDC006565 Follow this and additional works at: https://digitalcommons.fiu.edu/etd Part of the Chemistry Commons Recommended Citation Seither, Joshua Zolton, "Application of High Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances" (2018). FIU Electronic Theses and Dissertations. 3823. https://digitalcommons.fiu.edu/etd/3823 This work is brought to you for free and open access by the University Graduate School at FIU Digital Commons. It has been accepted for inclusion in FIU Electronic Theses and Dissertations by an authorized administrator of FIU Digital Commons. For more information, please contact [email protected]. FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida APPLICATION OF HIGH RESOLUTION MASS SPECTROMETRY FOR THE SCREENING AND CONFIRMATION OF NOVEL PSYCHOACTIVE SUBSTANCES A dissertation submitted in partial fulfillment of the requirements for the degree of DOCTOR OF PHILOSOPHY in CHEMISTRY by Joshua Zolton Seither 2018 To: Dean Michael R. Heithaus College of Arts, Sciences and Education This dissertation, written by Joshua Zolton Seither, and entitled Application of High- Resolution Mass Spectrometry for the Screening and Confirmation of Novel Psychoactive Substances, having been approved in respect to style and intellectual content, is referred to you for judgment. We have read this dissertation and recommend that it be approved. _______________________________________ Piero Gardinali _______________________________________ Bruce McCord _______________________________________ DeEtta Mills _______________________________________ Stanislaw Wnuk _______________________________________ Anthony DeCaprio, Major Professor Date of Defense: April 25, 2018 The dissertation of Joshua Zolton Seither is approved. -
2003-Pickard-Lsd-Trial-Transcript-Gordontoddskinner-01.Pdf
Case 5:00-cr-40104-RDR Document 269 Filed 02/11/03 Page 1 of 131 1 " . 'I 1 IN THE UNITED STATES DISTRICt '"COURT,; '\ i FOR THE DISTRICT OF KANSAS 2 TOPEKA, KANSAS I: 21-1 3 ::'~'":r"r"'" '. v ~.' , 4 UNITED STATES OF AMERICA, :.. , . .-.-.... ------ Plaintiff,) ~ 5 ) vs. ) Case No. 6 ) 00-40104-01/02 WILLIAM L. PICKARD and } 7 CLYDE APPERSON! } ------------- Defendants. } 8 TRANSCRIPT OF VOLUME I OF THE TESTIMONY OF 9 GORDON TODD SKINNER HAD DURING TRIAL BEFORE 10 HONORABLE RICHARD D. ROGERS and a jury of 12 11 on January 28, 2003 12 13 APPEARANCES: 14 For the Plaintiff: Mr. Gregory G. Hough Asst. U.S. Attorney 15 290 Federal Building 444 Quincy Street 16 Topeka, Kansas 66683 17 For the Defendant: Mr. William Rork (Pickard) Rork Law Office 18 1321 SW Topeka Blvd. Topeka, Kansas 66612 19 20 For the Defendant: Mr. Mark Bennett (Apperson) Bennett, Hendrix & Moylan 21 5605 SW Barrington Court S Topeka, Kansas 66614 22 Court Reporter: Kelli Stewart! CSR, RPR 23 Nora Lyon & Associates 1515 South Topeka Avenue 24 Topeka, Kansas 66612 25 NORA LYON & ASSOCIATES, INC. 1515 S.W. Topeka Blvd., Topeka, KS 66612 Phone: (785) 232-2545 FAX: (785) 232-2720 ?Jo~ Case 5:00-cr-40104-RDR Document 269 Filed 02/11/03 Page 2 of 131 1 I N D E X ~ 2 Certificate------------------- 131 3 4 WIT N E S 5 ON BEHALF OF THE GOVERNMENT: PAGE 6 GORDON TODD SKINNER 7 Direct Examination by Mr. Hough 3 8 9 10 11 12 13 '-' 14 15 16 17 18 19 20 21 22 23 24 25 NORA LYON & ASSOCIATES, INC. -
Neuropsychedelia
Neuropsychedelia The Revival of Hallucinogen Research since the Decade of the Brain Nicolas Langlitz UNIVERSITY OF CALIFORNIA PRESS Berkeley • Los Angeles • London Contents. University of California Press, one of the most distinguished university presses in the United States, enriches lives around the world by advancing scholarship in the humanities, social sciences, and natural sciences. Its activities are supported by the UC Press Foundation and by philanthropic contributions from individuals and institutions. For more information, visit www.ucpress.edu. University of California Press Berkeley and Los Angeles, California University of California Press, Ltd. London, England © 2013 by The Regents of the University of California Acknowledgments Vtl Library of Congress Cataloging-in-Publication Data Introduction: Neuropsychopharmacology Langlitz, Nicolas, 1975-. Neuropsychedelia : the revival of hallucinogen as Spiritual Technology I research since the decade of the brain I Nicolas Langlitz. 1. Psychedelic Revival p. cm. Includes bibliographical references and index. 2. Swiss Psilocybin and US Dollars 53 ISBN 978-0-520-27481-5 (cloth: alk. paper) ISBN 978-0-520-27482-2 (pbk. : alk. paper) 3. The Varieties of Psychedelic Lab Experience I. Hallucinogenic drugs-Research. 2. Neuropsychopharmacology. 3. Hallucinogenic 4. Enacting Experimental Psychoses 2 drugs and religious experience. 1. Title. I3 BF209·H34L36 2013 - I54·4-dc23 5. Between Animality and Divinity I66 2012022916 6. Mystic Materialism 2°4 Manufactured in the United States of America Conclusion: Fieldwork in Perennial Philosophy 243 21 20 19 18 17 16 15 14 13 10 9 8 7 6 5 4 3 2 In keeping with a commitment to support Notes environmentally responsible and sustainable printing practices, UC Press has printed this book on 50-pound Bibliography Enterprise, a 30% post-consumer-waste, recycled, Index deinked fiber that is processed chlorine-free. -
Appendix-2Final.Pdf 663.7 KB
North West ‘Through the Gate Substance Misuse Services’ Drug Testing Project Appendix 2 – Analytical methodologies Overview Urine samples were analysed using three methodologies. The first methodology (General Screen) was designed to cover a wide range of analytes (drugs) and was used for all analytes other than the synthetic cannabinoid receptor agonists (SCRAs). The analyte coverage included a broad range of commonly prescribed drugs including over the counter medications, commonly misused drugs and metabolites of many of the compounds too. This approach provided a very powerful drug screening tool to investigate drug use/misuse before and whilst in prison. The second methodology (SCRA Screen) was specifically designed for SCRAs and targets only those compounds. This was a very sensitive methodology with a method capability of sub 100pg/ml for over 600 SCRAs and their metabolites. Both methodologies utilised full scan high resolution accurate mass LCMS technologies that allowed a non-targeted approach to data acquisition and the ability to retrospectively review data. The non-targeted approach to data acquisition effectively means that the analyte coverage of the data acquisition was unlimited. The only limiting factors were related to the chemical nature of the analyte being looked for. The analyte must extract in the sample preparation process; it must chromatograph and it must ionise under the conditions used by the mass spectrometer interface. The final limiting factor was presence in the data processing database. The subsequent study of negative MDT samples across the North West and London and the South East used a GCMS methodology for anabolic steroids in addition to the General and SCRA screens. -
US Censors LSD Trial, Double Life Sentence Without Parole
FACT exposé : US censors LSD trial, double life sentence without parole The Strange Trip and Fall of Leonard Pickard Criminal Injustice in the Heartland CJ Hinke [email protected] Freedom Against Censorship Thailand (FACT) http://facthai.wordpress.com More than 13 million Americans have tried LSD. US President John F. Kennedy himself engaged in LSD sessions with his lover Mary Pinchot with acid supplied by Timothy Leary. His brother, US Attorney General Robert F. Kennedy, was a vocal critic of the LSD ban; his wife, Ethel, was successfully treated for alcoholism in LSD sessions at Vancouver’s Hollywood Hospital, under the auspices of the International Association for Psychedelic Therapy, which claimed a success rate of 80%. Both brothers were assassinated; few know that Pinchot was also assassinated in her Washington apartment in 1964; her address book was never found. This article addresses another kind of assassination, life sentences for LSD. Nike Atlas Minuteman ICBM The heartland of the United States is riddled with hundreds of nuclear missile silos, now relics of the cold war. Many of these 20+ acre properties were sold to individuals including those doomsday proponents who saw them as the perfect place for survival come Armageddon. The silos have 47-ton fortified blast doors and a 66,000-pound battery bank. They also seem to be popular as a great modern location for server farms and hacker camps. Wamego, Kansas, is the heart of the heartland and welcomed the silos for their government employment opportunities in the country’s farm belt. Waumego was named after Potawatomie chief Waumego but all the Potawatomies were killed in the American Indian Wars in frontier massacres during the mid-1800s. -
Toxicology Reference Material
toxicology Toxicology covers a wide range of disciplines, including therapeutic drug monitoring, clinical toxicology, forensic toxicology (drug driving, criminal and coroners), drugs in sport and work place drug testing, as well as academia and research. Those working in the field have a professional interest in the detection and measurement of alcohol, drugs, poisons and their breakdown products in biological samples, together with the interpretation of these measurements. Abuse and misuse of drugs is one of the biggest problems facing our society today. Acute poisoning remains one of the commonest medical emergencies, accounting for 10-20% of hospital admissions for general medicine [Dargan & Jones, 2001]. Many offenders charged with violent crimes, or victims of violent crime may have been under the influence of drugs at the time the act was committed. The use of mind-altering drugs in the work place, or whilst in control of a motor vehicle places others in danger [Drummer, 2001]. Performance enhancing drugs in sport make for an uneven playing field and distract from the core ethic of sportsmanship. Patterns of drug abuse around the world are constantly evolving. They vary between geographies; from one country to another and even from region to region or population to population within countries. With a European presence, a wide reaching network of global customers and distributors, and activate participation in relevant professional societies, Chiron is well positioned to develop and deliver relevant, and current standards to meet customer demand in this challenging field. Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. -
Stimulant Analytical Standards
Stimulant Analytical Standards Stimulants belong to a diverse group of psychoactive drugs whose function exerts a constant contribution to hyperactivity and impulse control. Illegal stimulant derivatives including amphetamines, arylcyclohexylamines, cathinones, cocaine/tropanes, phenethylamines, and piperazines are among the most widely abused across the US and Europe. However, the popularity of each substance, particularly in party culture settings, is frequently changing. Cayman offers more than 700 analytical standards for the identification of stimulants and is dedicated to working with the forensic community to quickly make reference standards available for new psychoactive substances (NPS). A library of mass spectral data containing many of Cayman’s emerging stimulant standards is freely available for download at www.caymanchem.com/CSL. More than 700 Stimulant Standards Available for · Amphetamines · Indanes · Arylcyclohexylamines · Phenethylamines · Cathinones · Piperazines · Cocaine & Tropanes · And More Tools to Rapidly Screen for Major Controlled Stimulants Cocaine/Heroin/Methamphetamine Mixture (CRM) Item No. 9002662 A CRM mixture of cocaine, heroin, and methamphetamine (1 mg/ml of each) GC-MS Drug Standard Mixture 4 Item No. 24632 A mixture of common stimulants, opioids, and Representative chromatogram of the compounds steroids as well as a synthetic cannabinoid and a included in the GC-MS Drug Standard Mixture 4 benzodiazepine (250 μg/ml of each) Peak order from left to right: α-Pyrrolidinobutiophenone, α-Pyrrolidinopentiophenone, -
Regulation on the Amendments of Regulation No. 233.2001.Pdf Date
REGULATION on the (12th) amendment of Regulation No. 233/2001, on habit-forming and narcotic substances and other controlled substances. Article 1 The title “The Minister of Health and Social Security” in the second paragraph of Article 2, the first paragraph of Article 6, in two places in the first paragraph of Article 7 and in Article 8 of the Regulation shall be replaced (with the appropriate grammatical case inflexions in Icelandic) by: The Icelandic Medicines Agency. Article 2 The words “the Minister” in two places in the second paragraph of Article two and in the third paragraph of Article 7 of the Regulation shall be replaced (with the appropriate grammatical cases inflections in Icelandic): the Icelandic Medicines Agency. Article 3 The words “on the prescribing of drugs and the design of prescriptions and the Regulation on the processing of prescriptions, the recording and dispensing of medicinal products” in the third paragraph of Article 3 shall be replaced by: medicinal product prescriptions and the dispensing of medicinal products, with subsequent amendments. Article 4 The word “prescribed” in the first paragraph of Article 4, the title of Chapter IV, in three places in the first, second and fourth paragraphs of Article 10 and in two places in the first and second paragraphs of Article 11 of the Regulation shall be replaced (with the appropriate grammatical case inflexions in Icelandic) by: dispensed. Article 5 The following amendments shall be made to the fifth paragraph of Article 5 of the Regulation: a. The title “the Ministry of Health and Social Security” shall be replaced by: the Icelandic Medicines Agency. -
New Psychoactive Substances (NPS)
New Psychoactive Substances (NPS) LGC Quality Reference ISO 9001 ISO/IEC 17025 ISO Guide 34 materials GMP/GLP ISO 13485 2019 ISO/IEC 17043 Science for a safer world LGC offers the most extensive and up-to-date range of New LGC is a global leader in Psychoactive Substances (NPS) measurement standards, reference materials. reference materials, laboratory services and proficiency testing. With 2,600 professionals working When you make a decision using The challenge The LGC response We are the UK’s in 21 countries, our analytical our resources, you can be sure it’s designated National measurement and quality control based on precise, robust data. And New Psychoactive Substances In response to the ever-expanding LGC Standards provides the widest Measurement services are second-to-none. together, we’re creating fairer, safer, (NPS) continue to be identified, range of NPS being developed, LGC range of reference materials Institute for chemical more confident societies worldwide. and it appears that moves by the has produced a comprehensive available from any single supplier. and bioanalytical As a global leader, we provide the United Nations and by individual range of reference materials that We work closely with leading widest range of reference materials lgcstandards.com countries to control lists of meet the rapidly changing demands manufacturers to provide improved measurement. available from any single supplier. named NPS may be encouraging of the NPS landscape. Many of access to reference materials, the development of yet further these products are produced under with an increasingly large range variants to avoid these controls. the rigorous quality assurance of parameters, for laboratories standards set out in ISO Guide 34. -
3~/3I·-I!.-- -Against- Index No.: Rjino.: DAN HEINS, Doing Business As SHINING STAR ENTERPRISES
SUPREME COURT OF THE STATE OF NEW YORK COUNTY OF ALBANY PEOPLE OF THE STATE OF NEW YORK, by ERIC T. SCHNEIDERMAN, Attorney General of the State ofNew York, Petitioner, AFFIRMATION 3~/3i·-I!.-- -against- Index No.: RJINo.: DAN HEINS, doing business as SHINING STAR ENTERPRISES, Respondent. DEANJ'JA R. NELSON, an attorney duly admitted to practice law in the State of New York, affirms the following under the penalties of perjury: 1. I am an Assistant Attorney General In Charge in the office of Eric T. Schneiderman, Attorney General of the State of New York (OAG), assigned to the Watertown Regional Office. I am fully familiar with the facts and circumstance of this proceeding, which are based on investigative materials contained in the files of the Attorney General's office. 2. I submit this Affirmation in support of Petitioner's application for an Order and Judgment permanently enjoining Respondent from engaging in deceptive, fraudulent and illegal business practices, requiring that Respondent produce an accounting of mislabeled and misbranded products sold and awarding and penalties and· costs to the State ofNew York 3. Unless otherwise indicated, I make this affirmation upon information and .belief, based upon my investigation, a review of documents and other evidence on file with the Department of Law. Annexed hereto in support of this petition are the fo Howing documents: Ex. I. Affidavit of Senior Investigator Chad Shelmidine, dated 7/6/12, together with Exhibits A-K; Ex. II. Affidavit of Dr. Maja Lundborg-Gray, M.D., FAAEM, FACEP, sworn to on July 5,2012, together with Exhibits A-G; Ex.