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Toxicology Reference Material toxicology Toxicology covers a wide range of disciplines, including therapeutic drug monitoring, clinical toxicology, forensic toxicology (drug driving, criminal and coroners), drugs in sport and work place drug testing, as well as academia and research. Those working in the field have a professional interest in the detection and measurement of alcohol, drugs, poisons and their breakdown products in biological samples, together with the interpretation of these measurements. Abuse and misuse of drugs is one of the biggest problems facing our society today. Acute poisoning remains one of the commonest medical emergencies, accounting for 10-20% of hospital admissions for general medicine [Dargan & Jones, 2001]. Many offenders charged with violent crimes, or victims of violent crime may have been under the influence of drugs at the time the act was committed. The use of mind-altering drugs in the work place, or whilst in control of a motor vehicle places others in danger [Drummer, 2001]. Performance enhancing drugs in sport make for an uneven playing field and distract from the core ethic of sportsmanship. Patterns of drug abuse around the world are constantly evolving. They vary between geographies; from one country to another and even from region to region or population to population within countries. With a European presence, a wide reaching network of global customers and distributors, and activate participation in relevant professional societies, Chiron is well positioned to develop and deliver relevant, and current standards to meet customer demand in this challenging field. Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA CONTENTS SINGLE STANDARDS Analgesics (non-opioid) 1-4 Anaesthetics 4 Antibiotics 5 Anticancer 5 Anticoagulants 6 Anticonvulsants / Antiepileptics 6-7 Antidepressants 7-10 Antidiabetics 10 Antidyskinetic / Antimuscarinics / Antiparkinsonian 11 Antiemetics 11-12 Antifungals 12 Antihistamines 12-13 Anti-impotence 13 Anti-insomnia 13-14 Antimalarial 14 Antimicrobial 14 Antipsycotics 15-16 Antiretrovirals 16 Barbiturates 16 Benzodiazepines 16-20 Cannabinoids (Phyto) 21 Cardiac drugs 21-23 Cocaine and related compounds 23-25 Contrast media 25 Enzymes 25 Ephedrines 25-26 Ethanol and related compounds 26-28 Gastrointestinal drugs 28-29 Neurotransmitters 29 New psychoactive substances (NPS) 29-52 Amphetamines 29-31 Methamphetamines 31-33 Methylenedioxyphenethylamines 33 2C Phenethylamines (psychedelics) 34 Benzofuries (APBs and APDBs) 35 Indanes 35-36 Cathinones 36-38 Piperazines 38-39 Synthetic cannabinoids (Spice) 39-47 Designer forms of pharmaceuticals 47 Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA Quinazolinones 47 Methylphenidate related compounds 47-48 Other pharmaceuticals 48-49 Synthetic opioids 49 GHB and GBL 49 Diarylethylamines 50 Aryl cyclohexylamines 50 Tryptamines 50-51 Plant chemicals 51 Miscellaneous NPS 51-52 Nicotine and related compounds 52-53 Obstetrics 53 Opioids 53-58 Respiratory agents (including methylxanthines) 58-59 Steroids and Hormones 59-60 Vitamins 61 DRUG MIXTURES Amphetamines 62 Anticonvulsants / Antiepileptics 62 Antidepressants 63 Benzodiazepines 63 Cocaine 64 Congener alcohols 64 Opiates 64 Pharmaceutical residues 65 X-ray Contrast media 66 Z-Drugs 66 CALIBRATION SETS Amphetamines and Opiates 67 Benzoylecgonine and Benzodiazepines 67 THC-acid 67 Zopiclone, Zolpidem and 6-MAM 67 INDEX Alphabetical category index 68-89 Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA 1 SINGLE STANDARDS Analgesics (non-opioid) Catalogue No. Description (Abbreviation) Cas No. Concentration Solvent Volume Aceclofenac 9470.16-100-ME Aceclofenac 89796-99-6 100 µg/mL methanol 1 mL Aceclofenac Imp. I 9818.14-100-ME 15362-40-0 100 µg/mL methanol 1 mL (1-(2,6-Dichlorophenyl)indolin-2-one) Aceclofenac Imp. I 9818.14-10MG 15362-40-0 neat neat 10 mg (1-(2,6-Dichlorophenyl)indolin-2-one) Acetaminophen (Paracetamol) 2524.8-K-ME Acetaminophen 103-90-2 1000 µg/mL methanol 1 mL 2524.8-500MG Acetaminophen 103-90-2 neat neat 500 mg 9244.8-K-ME Acetaminophen-d3 (acetamide-d3 ) 60902-28-5 100 µg/mL methanol 1 mL 9244.8-10MG Acetaminophen-d3 (acetamide-d3 ) 60902-28-5 neat neat 10 mg 9244.8-100MG Acetaminophen-d3 (acetamide-d3 ) 60902-28-5 neat neat 100 mg 9245.8-100-ME Acetaminophen-d4 (phenyl-d4 ) 64315-36-2 100 µg/mL methanol 1 mL 9245.8-K-ME Acetaminophen-d4 (phenyl-d4 ) 64315-36-2 1000 µg/mL methanol 1 mL 9245.8-10MG Acetaminophen-d4 (phenyl-d4 ) 64315-36-2 neat neat 10 mg 9245.8-100MG Acetaminophen-d4 (phenyl-d4 ) 64315-36-2 neat neat 100 mg Acetaminophen Imp. B 2549.9-100-ME 1693-37-4 100 µg/mL methanol 1 mL (N -(4-Hydroxyphenyl)-propionamide) Acetaminophen Imp. B 2549.9-100MG 1693-37-4 neat neat 100 mg (N -(4-Hydroxyphenyl)-propionamide) Acetaminophen Imp. E 9821.8-100MG 99-93-4 neat neat 100 mg (1-(4-Hydroxyphenyl)ethanone) Acetaminophen Imp. F 2087.6-K-ME 100-02-7 1000 µg/mL methanol 1 mL (4-Nitrophenol) Acetaminophen Imp. F 2087.6-100MG 100-02-7 neat neat 100 mg (4-Nitrophenol) Acetaminophen Imp. H 2550.10-100-ME 2633-33-8 100 µg/mL methanol 1 mL (N,O- Diacetyl-4-aminophenol) Acetaminophen Imp. H 2550.10-100MG 2633-33-8 neat neat 100 mg (N,O- Diacetyl-4-aminophenol) Acetaminophen Imp. I 9221.8-100MG 118-93-4 neat neat 100 mg (1-(2-Hydroxyphenyl)ethanone, 2-Hydroxyacetophenone) Acetaminophen Imp. J 2512.8-K-ME 539-03-7 1000 µg/mL methanol 1 mL (4'-Chloroacetanilide) Acetaminophen Imp. J 2512.8-100MG 539-03-7 neat neat 100 mg (4'-Chloroacetanilide) Acetaminophen Imp. K 2519.6-K-ME 123-30-8 1000 µg/mL methanol 1 mL (4-Aminophenol) Acetaminophen Imp. K 2519.6-500MG 123-30-8 neat neat 500 mg (4-Aminophenol) Acetylsalicylic acid (Aspirin) 2513.9-K-ME Acetylsalicylic acid 50-78-2 1000 µg/mL methanol 1 mL 2513.9-100MG Acetylsalicylic acid 50-78-2 neat neat 100 mg 2513.9-500MG Acetylsalicylic acid 50-78-2 neat neat 500 mg Acetylsalicylic acid Imp. A 2514.7-K-ME 99-96-7 1000 µg/mL methanol 1 mL (4-Hydroxybenzoic acid) Acetylsalicylic acid Imp. A 2514.7-100MG 99-96-7 neat neat 100 mg (4-Hydroxybenzoic acid) Acetylsalicylic acid Imp. B 2539.8-K-ME 636-46-4 1000 µg/mL methanol 1 mL (4-Hydroxyisophthalic acid, 4-Hydroxybenzene-1,3-dicarboxylic acid) Acetylsalicylic acid Imp. B 2539.8-100MG 636-46-4 neat neat 100 mg (4-Hydroxyisophthalic acid, 4-Hydroxybenzene-1,3-dicarboxylic acid) Acetylsalicylic acid Imp. C 2515.7-K-ME 69-72-7 1000 µg/mL methanol 1 mL (Salicylic acid, 2-Hydroxybenzoic acid) Acetylsalicylic acid Imp. C 2515.7-500MG 69-72-7 neat neat 500 mg (Salicylic acid, 2-Hydroxybenzoic acid) Chiron AS Stiklestadvn. 1 N-7041 Trondheim Norway Phone No.: +47 73 87 44 90 Fax No.: +47 73 87 44 99 E-mail: [email protected] Website: www.chiron.no Org. No.: NO 967 607 657 MVA 2 Analgesics (non-opioid) continued… Catalogue No. Description (Abbreviation) Cas No. Concentration Solvent Volume Acetylsalicylic acid (Aspirin) Acetylsalicylic acid Imp. D 2516.16-100-ME 530-75-6 100 µg/mL methanol 1 mL (Acetylsalicylsalicylic acid) Acetylsalicylic acid Imp. D 2516.16-10MG 530-75-6 neat neat 10 mg (Acetylsalicylsalicylic acid) Acetylsalicylic acid Imp. D 2516.16-25MG 530-75-6 neat neat 25 mg (Acetylsalicylsalicylic acid) Acetylsalicylic acid Imp. D 2516.16-100MG 530-75-6 neat neat 100 mg (Acetylsalicylsalicylic acid) Acetylsalicylic acid Imp. F 2551.18-100-ME 1466-82-6 100 µg/mL methanol 1 mL (O- Acetylsalicylic anhydride) Acetylsalicylic acid Imp. F 2551.18-100MG 1466-82-6 neat neat 100 mg (O- Acetylsalicylic anhydride) 2710.14-100-ME 2-(2,4-Dihydroxybenzoyl)benzoic acid 2513-33-9 100 µg/mL methanol 1 mL Salicylic acid 2515.7-K-ME 69-72-7 1000 µg/mL methanol 1 mL (2-Hydroxybenzoic acid) Salicylic acid 2515.7-500MG 69-72-7 neat neat 500 mg (2-Hydroxybenzoic acid) 9242.7-K-ME Salicylic acid-d4 (3,4,5,6-d4 ) 78646-17-0 1000 µg/mL methanol 1 mL 9242.7-K-MEx10 Salicylic acid-d4 (3,4,5,6-d4 ) 78646-17-0 1000 µg/mL methanol 1 mL 9242.7-10MG Salicylic acid-d4 (3,4,5,6-d4 ) 78646-17-0 neat neat 10 mg 9243.7-K-ME Salicylic acid-d6 (perdeuterated) 285979-87-5 1000 µg/mL methanol 1 mL 9243.7-K-MEx10 Salicylic acid-d6 (perdeuterated) 285979-87-5 1000 µg/mL methanol 1 mL 9243.7-K-10MG Salicylic acid-d6 (perdeuterated) 285979-87-5 neat neat 10 mg Salicylic acid Imp. C 1427.6-K-ME 108-95-2 1000 µg/mL methanol 1 mL (Phenol) Salicylic acid Imp. C 1427.6-1G 108-95-2 neat neat 1 g (Phenol) 10258.7-1G 4-Aminosalicylic acid 65-49-6 neat neat 1 g Diclofenac 9467.14-K-ME Diclofenac 15307-86-5 1000 µg/mL methanol 1 mL 9321.14-K-ME Diclofenac-d4 (phenyl-d4 ) 153466-65-0 1000 µg/mL methanol 1 mL 9321.14-5MG Diclofenac-d4 (phenyl-d4 ) 153466-65-0 neat neat 5 mg Ethenzamide (2-Ethoxybenzamide) 10439.9-K-ME Ethenzamide 938-73-8 1000 µg /mL methanol 1 mL 10439.9-10MG Ethenzamide 938-73-8 neat neat 10 mg 10439.9-100MG Ethenzamide 938-73-8 neat neat 100 mg Etoricoxib (Arcoxia) 11414.18-10MG Etoricoxib 202409-33-4 neat neat 10 mg Hydroxychloroquine Hydroxychloroquine 11348.18-100MG 118-42-3 neat neat 100 mg (2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol) Hydroxychloroquine sulfate 11347.18-100MG 2-((4-(7-Chloroquinolin-4-ylamino)pentyl)(ethyl)amino)ethanol 747-36-4 neat neat 100 mg sulfate Ibuprofen 2525.13-K-ME (± )- Ibuprofen 15687-27-1 1000 µg/mL methanol 1 mL 2525.13-100MG (± )- Ibuprofen 15687-27-1 neat neat 100 mg 2525.13-500MG (± )- Ibuprofen 15687-27-1 neat neat 500 mg 3851.13-K-ME (±)- Ibuprofen-d3 (α-methyl-d3 ) 121662-14-4 1000 µg/mL methanol 1 mL 3851.13-K-IO (±)- Ibuprofen-d3 (α-methyl-d3 ) 121662-14-4 1000 µg/mL isooctane 1 mL Ibuprofen Imp.
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