Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances 2017
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Retention Indices for Frequently Reported Compounds of Plant Essential Oils
Retention Indices for Frequently Reported Compounds of Plant Essential Oils V. I. Babushok,a) P. J. Linstrom, and I. G. Zenkevichb) National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA (Received 1 August 2011; accepted 27 September 2011; published online 29 November 2011) Gas chromatographic retention indices were evaluated for 505 frequently reported plant essential oil components using a large retention index database. Retention data are presented for three types of commonly used stationary phases: dimethyl silicone (nonpolar), dimethyl sili- cone with 5% phenyl groups (slightly polar), and polyethylene glycol (polar) stationary phases. The evaluations are based on the treatment of multiple measurements with the number of data records ranging from about 5 to 800 per compound. Data analysis was limited to temperature programmed conditions. The data reported include the average and median values of retention index with standard deviations and confidence intervals. VC 2011 by the U.S. Secretary of Commerce on behalf of the United States. All rights reserved. [doi:10.1063/1.3653552] Key words: essential oils; gas chromatography; Kova´ts indices; linear indices; retention indices; identification; flavor; olfaction. CONTENTS 1. Introduction The practical applications of plant essential oils are very 1. Introduction................................ 1 diverse. They are used for the production of food, drugs, per- fumes, aromatherapy, and many other applications.1–4 The 2. Retention Indices ........................... 2 need for identification of essential oil components ranges 3. Retention Data Presentation and Discussion . 2 from product quality control to basic research. The identifi- 4. Summary.................................. 45 cation of unknown compounds remains a complex problem, in spite of great progress made in analytical techniques over 5. -
Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole Kate Cummings Clemson University, [email protected]
Clemson University TigerPrints All Theses Theses 5-2012 Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole Kate Cummings Clemson University, [email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_theses Part of the Forest Sciences Commons Recommended Citation Cummings, Kate, "Sassafras Tea: Using a Traditional Method of Preparation to Reduce the Carcinogenic Compound Safrole" (2012). All Theses. 1345. https://tigerprints.clemson.edu/all_theses/1345 This Thesis is brought to you for free and open access by the Theses at TigerPrints. It has been accepted for inclusion in All Theses by an authorized administrator of TigerPrints. For more information, please contact [email protected]. SASSAFRAS TEA: USING A TRADITIONAL METHOD OF PREPARATION TO REDUCE THE CARCINOGENIC COMPOUND SAFROLE A Thesis Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirements for the Degree Master of Science Forest Resources by Kate Cummings May 2012 Accepted by: Patricia Layton, Ph.D., Committee Chair Karen C. Hall, Ph.D Feng Chen, Ph. D. Christina Wells, Ph. D. ABSTRACT The purpose of this research is to quantify the carcinogenic compound safrole in the traditional preparation method of making sassafras tea from the root of Sassafras albidum. The traditional method investigated was typical of preparation by members of the Eastern Band of Cherokee Indians and other Appalachian peoples. Sassafras is a tree common to the eastern coast of the United States, especially in the mountainous regions. Historically and continuing until today, roots of the tree are used to prepare fragrant teas and syrups. -
End-Of-Line Hyphenation of Chemical Names (IUPAC Provisional
Pure Appl. Chem. 2020; aop IUPAC Recommendations Albert J. Dijkstra*, Karl-Heinz Hellwich, Richard M. Hartshorn, Jan Reedijk and Erik Szabó End-of-line hyphenation of chemical names (IUPAC Provisional Recommendations) https://doi.org/10.1515/pac-2019-1005 Received October 16, 2019; accepted January 21, 2020 Abstract: Chemical names and in particular systematic chemical names can be so long that, when a manu- script is printed, they have to be hyphenated/divided at the end of a line. Many systematic names already contain hyphens, but sometimes not in a suitable division position. In some cases, using these hyphens as end-of-line divisions can lead to illogical divisions in print, as can also happen when hyphens are added arbi- trarily without considering the ‘chemical’ context. The present document provides recommendations and guidelines for authors of chemical manuscripts, their publishers and editors, on where to divide chemical names at the end of a line and instructions on how to avoid these names being divided at illogical places as often suggested by desk dictionaries. Instead, readability and chemical sense should prevail when authors insert optional hyphens. Accordingly, the software used to convert electronic manuscripts to print can now be programmed to avoid illogical end-of-line hyphenation and thereby save the author much time and annoy- ance when proofreading. The recommendations also allow readers of the printed article to determine which end-of-line hyphens are an integral part of the name and should not be deleted when ‘undividing’ the name. These recommendations may also prove useful in languages other than English. -
COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Application of Biomarker Compounds As Tracers for Sources and Fates of Natural and Anthropogenic Organic Matter in Tile Environment
AN ABSTRACT OF THE DISSERTATION OF Daniel R. Oros for the degree of Doctor of Philosophy in Environmental Sciences presented on September 24. 1999. Title: Application of Biomarker Compoundsas Tracers for Sources and Fates of Natural and Anthropogenic Organic Matter in the Environment. Redacted for Privacy Abstract approved: Bernd R.T. Simoneit Determination of the source and fate of natural (higher plant lipids, marine lipids, etc.) and anthropogenically (e.g., petroleum, coal emissions) derived hydrocarbons and oxygenated compounds in the environment was accomplished using gas chromatography (GC) and gas chromatography-mass spectrometry (GC- MS) to characterize or identify molecular biomarkers to be utilized as tracers. The distributions and abundances of biomarkers such as straight chain homologous series (e.g., n-alkanes, n-alkanoic acids, n-alkan-2-ones, n-alkanols, etc.) and cyclic terpenoid compounds (e.g., sesquiterpenoids, diterpenoids, steroids, triterpenoids) were identified in epicuticular waxes from conifers of western North America (natural emissions). These biomarkers and their thermal alteration derivativeswere also identified in smoke emissions from known vegetation sources (e.g., conifers, deciduous trees and grasses) and were then applied as tracers in soils, soils that contained wildfire residues and soillriver mud washout after wildfire burning. Where possible, the reaction pathways of transformation from the parentprecursor compounds to intermediate and final alteration products were determined from GC- MS data. In addition, molecular tracer analysis was applied to air, water and sediment samples collected from a lacustrine setting (Crater Lake, OR) in order to determine the identities, levels and fates of anthropogenic (i.e., petroleum hydrocarbon contamination from boating and related activities) hydrocarbons ina pristine organic matter sink. -
Analysis of Ammonia and Volatile Organic Amine Emissions in a Confined Poultry Facility
Utah State University DigitalCommons@USU All Graduate Theses and Dissertations Graduate Studies 5-2010 Analysis of Ammonia and Volatile Organic Amine Emissions in a Confined Poultry Facility Hanh Hong Thi Dinh Utah State University Follow this and additional works at: https://digitalcommons.usu.edu/etd Part of the Analytical Chemistry Commons Recommended Citation Dinh, Hanh Hong Thi, "Analysis of Ammonia and Volatile Organic Amine Emissions in a Confined Poultry Facility" (2010). All Graduate Theses and Dissertations. 598. https://digitalcommons.usu.edu/etd/598 This Thesis is brought to you for free and open access by the Graduate Studies at DigitalCommons@USU. It has been accepted for inclusion in All Graduate Theses and Dissertations by an authorized administrator of DigitalCommons@USU. For more information, please contact [email protected]. Copyright © Hanh Hong Thi Dinh 2010 All Right Reserved iii ABSTRACT Analysis of Ammonia and Volatile Organic Amine Emissions in a Confined Poultry Facility by Hanh Hong Thi Dinh, Master of Science Utah State University, 2010 Major Professor: Dr Robert S. Brown Department: Chemistry and Biochemistry The National Air Emission Monitoring Study (NAEMS) project was funded by the Agricultural Air Research Council (AARC) to evaluate agricultural emissions nationwide. Utah State University (USU) is conducting a parallel study on agricultural emissions at a Cache Valley poultry facility. As part of this parallel study, samples of animal feed, eggs and animal waste were collected weekly from three manure barns (designated: manure barn, barn 4 - manure belt and barn 5 - high rise) from May 2008 to November 2009. These samples were analyzed to determine ammonia content, total Kjeldahl nitrogen content and ammonia emission. -
Synthetic Drugs: Overview and Issues for Congress
Synthetic Drugs: Overview and Issues for Congress Lisa N. Sacco Analyst in Illicit Drugs and Crime Policy Kristin Finklea Specialist in Domestic Security May 3, 2016 Congressional Research Service 7-5700 www.crs.gov R42066 Synthetic Drugs: Overview and Issues for Congress Summary Synthetic drugs, as opposed to natural drugs, are chemically produced in a laboratory. Their chemical structure can be either identical to or different from naturally occurring drugs, and their effects are designed to mimic or even enhance those of natural drugs. When produced clandestinely, they are not typically controlled pharmaceutical substances intended for legitimate medical use. Designer drugs are a form of synthetic drugs. They contain slightly modified molecular structures of illegal or controlled substances, and they are modified in order to circumvent existing drug laws. While the issue of synthetic drugs and their abuse is not new, Congress has demonstrated a renewed concern with the issue. From 2009 to 2011, synthetic drug abuse was reported to have dramatically increased. During this time period, calls to poison control centers for incidents relating to harmful effects of synthetic cannabinoids (such as “K2” and “Spice”) and stimulants (such as “bath salts”) increased at what some considered to be an alarming rate. The number of hospital emergency department visits involving synthetic cannabinoids more than doubled from 2010 to 2011. In 2012 and 2013, however, the number of calls to poison control centers for incidents relating to harmful effects of synthetic cannabinoids and synthetic stimulants decreased. Calls regarding bath salts have declined each year since 2011, while calls regarding synthetic cannabinoids have increased since the drops in 2012 and 2013. -
Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017
Q UO N T FA R U T A F E BERMUDA PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 BR 111 / 2017 The Minister responsible for health, in exercise of the power conferred by section 48A(1) of the Pharmacy and Poisons Act 1979, makes the following Order: Citation 1 This Order may be cited as the Pharmacy and Poisons (Third and Fourth Schedule Amendment) Order 2017. Repeals and replaces the Third and Fourth Schedule of the Pharmacy and Poisons Act 1979 2 The Third and Fourth Schedules to the Pharmacy and Poisons Act 1979 are repealed and replaced with— “THIRD SCHEDULE (Sections 25(6); 27(1))) DRUGS OBTAINABLE ONLY ON PRESCRIPTION EXCEPT WHERE SPECIFIED IN THE FOURTH SCHEDULE (PART I AND PART II) Note: The following annotations used in this Schedule have the following meanings: md (maximum dose) i.e. the maximum quantity of the substance contained in the amount of a medicinal product which is recommended to be taken or administered at any one time. 1 PHARMACY AND POISONS (THIRD AND FOURTH SCHEDULE AMENDMENT) ORDER 2017 mdd (maximum daily dose) i.e. the maximum quantity of the substance that is contained in the amount of a medicinal product which is recommended to be taken or administered in any period of 24 hours. mg milligram ms (maximum strength) i.e. either or, if so specified, both of the following: (a) the maximum quantity of the substance by weight or volume that is contained in the dosage unit of a medicinal product; or (b) the maximum percentage of the substance contained in a medicinal product calculated in terms of w/w, w/v, v/w, or v/v, as appropriate. -
2020 International Narcotics Control Strategy Report
United States Department of State Bureau for International Narcotics and Law Enforcement Affairs International Narcotics Control Strategy Report Volume I Drug and Chemical Control March 2020 INCSR 2020 Volume 1 Table of Contents Table of Contents Common Abbreviations ..................................................................................................................................... iii International Agreements.................................................................................................................................... v INTRODUCTION ..................................................................................................................................... 1 Legislative Basis for the INCSR ......................................................................................................................... 2 Presidential Determination ................................................................................................................................. 7 Policy and Program Developments .................................................................................................... 12 Overview ......................................................................................................................................................... 13 Methodology for U.S. Government Estimates of Illegal Drug Production .......................................................... 18 Parties to UN Conventions .............................................................................................................................. -
Exactly As Received Mic 61-929 MERRYMAN, Earl L Ew Is. THE
This dissertation has been microfilmed exactly as received Mic 61-929 MERRYMAN, Earl Lewis. THE ISOTOPIC EXCHANGE REACTION BETWEEN Mn AND MnO” . 4 The Ohio State University, Ph.D, 1960 Chemistry, physical University Microfilms, Inc., Ann Arbor, Michigan THE ISOTOPIC EXCHANGE REACTION BETTAIEEN Mn** AND ItaO ^ DISSERTATION Presented in P&rtial Fulfillment of the Requirements for the Degree Doctor of Philosophy In the Graduate School of The Ohio S tate U niversity By Earl Lewis Ferryman, B.Sc* The Ohio State University I960 Approved by Department oy Chenletry 1C mnriEDGiBiT The author wlshea to e:qpr«as his approoiation to Profoaaor Alfred B. Garrett for hie superrieion and enocur- agement during the oouree of this research* and for his sincere interest in mj eelfare both as an undergraduate and graduate student at Ohio State University. I also wish to thank the Ohio State University Cheidstry Depsurtnent for the Assistant ships granted me during the 1 9 5 6* 7 "^ aeademlo years. The author also gratefully acknowledges the Fellowships granted me by the American Cyansuald Company during the 1959*60 academic year and by the National Science Foundation during the Summer Q u a rte r of I960* i i TABI£ OP CONTEHTS PAOE INTRODUCTION ............................................................................................................... 1 Àpplloationa of Radloaotirlty in Chomiatry 1 The Problem and Its H latory ....................................................... .. 1 The Problem Reeulting from Early Work 5 Statement of the Problem .......................... -
APPENDIX G Acid Dissociation Constants
harxxxxx_App-G.qxd 3/8/10 1:34 PM Page AP11 APPENDIX G Acid Dissociation Constants § ϭ 0.1 M 0 ؍ (Ionic strength ( † ‡ † Name Structure* pKa Ka pKa ϫ Ϫ5 Acetic acid CH3CO2H 4.756 1.75 10 4.56 (ethanoic acid) N ϩ H3 ϫ Ϫ3 Alanine CHCH3 2.344 (CO2H) 4.53 10 2.33 ϫ Ϫ10 9.868 (NH3) 1.36 10 9.71 CO2H ϩ Ϫ5 Aminobenzene NH3 4.601 2.51 ϫ 10 4.64 (aniline) ϪO SNϩ Ϫ4 4-Aminobenzenesulfonic acid 3 H3 3.232 5.86 ϫ 10 3.01 (sulfanilic acid) ϩ NH3 ϫ Ϫ3 2-Aminobenzoic acid 2.08 (CO2H) 8.3 10 2.01 ϫ Ϫ5 (anthranilic acid) 4.96 (NH3) 1.10 10 4.78 CO2H ϩ 2-Aminoethanethiol HSCH2CH2NH3 —— 8.21 (SH) (2-mercaptoethylamine) —— 10.73 (NH3) ϩ ϫ Ϫ10 2-Aminoethanol HOCH2CH2NH3 9.498 3.18 10 9.52 (ethanolamine) O H ϫ Ϫ5 4.70 (NH3) (20°) 2.0 10 4.74 2-Aminophenol Ϫ 9.97 (OH) (20°) 1.05 ϫ 10 10 9.87 ϩ NH3 ϩ ϫ Ϫ10 Ammonia NH4 9.245 5.69 10 9.26 N ϩ H3 N ϩ H2 ϫ Ϫ2 1.823 (CO2H) 1.50 10 2.03 CHCH CH CH NHC ϫ Ϫ9 Arginine 2 2 2 8.991 (NH3) 1.02 10 9.00 NH —— (NH2) —— (12.1) CO2H 2 O Ϫ 2.24 5.8 ϫ 10 3 2.15 Ϫ Arsenic acid HO As OH 6.96 1.10 ϫ 10 7 6.65 Ϫ (hydrogen arsenate) (11.50) 3.2 ϫ 10 12 (11.18) OH ϫ Ϫ10 Arsenious acid As(OH)3 9.29 5.1 10 9.14 (hydrogen arsenite) N ϩ O H3 Asparagine CHCH2CNH2 —— —— 2.16 (CO2H) —— —— 8.73 (NH3) CO2H *Each acid is written in its protonated form. -
United States Patent [19] [11] Patent Number: 5,368,832 Buckholtz Et A1
USOO5368832A United States Patent [19] [11] Patent Number: 5,368,832 Buckholtz et a1. [45] Date of Patent: Nov. 29, 1994 [54] ZERO DISCI'IARGE PRQCESS FOR 4,330,515 5/1982 Campbell .......................... .. 423/316 MANUFACI'URING OF PHOSPHOROUS 4,380,531 4/1983 Wisnouskas ....................... .. 423/316 ACID AND HYPOPHOSPHOROUS ACID FOREIGN PATENT DOCUMENTS [75] 1I1v¢m°rs= HWY E- Buckh‘?tz, Lewiswn; 0007493 2/1980 European Pat. Off. .......... .. 423/317 Mohan S. Saran, Grand Island, both 254166 11/1986 Japan _ Of N.Y.; Frederick C. Leiterf, 7900920 11/1979 WIPO ............................... .. 423/316 Madison; David A. Flautt, Ashtabula, both of Ohio Primary iExaminer-Michael Lewis Assistant Examiner—-Stephen G. Kalinchak [73] Assignee: gggiggg?gg? Corporation’ gltltglrgey, Agent, or Firm-Wayne A. Jones; Richard D. [21] Appl. No.: 711,841 [57] ' ABS Cr [22] Flled' : Jun . 7 ’ 1991 Dlsclosed. 1s. a method of making. phosphorous acid. or [51] Int. Cl.5 .................. .. C01B 25/165; COlB 25/163 hypophosphomus acid by reacting hydrogen chloride U:S. C1. ................................... .. 423/ 316; 423/ 317 with a sodium phosphite or a sodium hypophosphite’ [58] Field of Search ............. .. 423/ 167, 307, 316, 317, respectively, in the presence of water to precipitate 423/321 R sodium chloride crystals and form the acid. The acid is [56] References Cited separated from the sodium chloride crystals and-can be US PATENT DOCUMENTS passed through amon exchange column that 1s pref erably loaded with phosphite or hypophosphite lons, 2,595,198 4/1952 Leffore et a1. ............ .. 423/316 respectively, to remove'residual chloride ions_ 2,711,388 6/1955 Mottern et a1.