A Long Term Follow up to a Randomized Controlled Trial of Comprehensive Behavioral Intervention for Tics Flint Martin Espil University of Wisconsin-Milwaukee
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Tic Disorders
No. 35 May 2012 Tic Disorders A tic is a problem in which a part of the body moves repeatedly, quickly, suddenly and uncontrollably. Tics can occur in any body part, such as the face, shoulders, hands or legs. They can be stopped voluntarily for brief periods. Sounds that are made involuntarily (such as throat clearing, sniffing) are called vocal tics. Most tics are mild and hardly noticeable. However, in some cases they are frequent and severe, and can affect many areas of a child's life. The most common tic disorder is called "transient tic disorder" and may affect up to 10 percent of children during the early school years. Teachers or others may notice the tics and wonder if the child is under stress or "nervous." Transient tics go away by themselves. Some may get worse with anxiety, tiredness, and some medications. Some tics do not go away. Tics which last one year or more are called "chronic tics." Chronic tics affect less than one percent of children and may be related to a special, more unusual tic disorder called Tourette's Disorder. Children with Tourette's Disorder have both body and vocal tics (throat clearing). Some tics disappear by early adulthood, and some continue. Children with Tourette's Disorder may also have problems with attention, and learning disabilities. They may act impulsively, and/or develop obsessions and compulsions. Sometimes people with Tourette's Disorder may blurt out obscene words, insult others, or make obscene gestures or movements. They cannot control these sounds and movements and should not be blamed for them. -
Neurobiology of the Premonitory Urge in Tourette Syndrome: Pathophysiology and Treatment Implications
View metadata, citation and similar papers at core.ac.uk brought to you by CORE HHS Public Access provided by Aston Publications Explorer Author manuscript Author ManuscriptAuthor Manuscript Author J Neuropsychiatry Manuscript Author Clin Neurosci Manuscript Author . Author manuscript; available in PMC 2017 April 28. Published in final edited form as: J Neuropsychiatry Clin Neurosci. 2017 ; 29(2): 95–104. doi:10.1176/appi.neuropsych.16070141. Neurobiology of the premonitory urge in Tourette syndrome: Pathophysiology and treatment implications Andrea E. Cavanna1,2,3,*, Kevin J Black4, Mark Hallett5, and Valerie Voon6,7,8 1Department of Neuropsychiatry Research Group, BSMHFT and University of Birmingham, Birmingham, UK 2School of Life and Health Sciences, Aston University, Birmingham, UK 3University College London and Institute of Neurology, London, UK 4Departments of Psychiatry, Neurology, Radiology, and Anatomy & Neuroscience, Washington University School of Medicine, St. Louis, MO, USA 5Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA 6Department of Psychiatry, University of Cambridge, Cambridge, UK 7Behavioural and Clinical Neurosciences Institute, Cambridge, UK 8Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK Abstract Motor and vocal tics are relatively common motor manifestations identified as the core features of Tourette syndrome. Although traditional descriptions have focused on objective phenomenological -
Tourette's Syndrome
Tourette’s Syndrome CHRISTOPHER KENNEY, MD; SHENG-HAN KUO, MD; and JOOHI JIMENEZ-SHAHED, MD Baylor College of Medicine, Houston, Texas Tourette’s syndrome is a movement disorder most commonly seen in school-age children. The incidence peaks around preadolescence with one half of cases resolving in early adult- hood. Tourette’s syndrome is the most common cause of tics, which are involuntary or semi- voluntary, sudden, brief, intermittent, repetitive movements (motor tics) or sounds (phonic tics). It is often associated with psychiatric comorbidities, mainly attention-deficit/hyperac- tivity disorder and obsessive-compulsive disorder. Given its diverse presentation, Tourette’s syndrome can mimic many hyperkinetic disorders, making the diagnosis challenging at times. The etiology of this syndrome is thought to be related to basal ganglia dysfunction. Treatment can be behavioral, pharmacologic, or surgical, and is dictated by the most incapacitating symp- toms. Alpha2-adrenergic agonists are the first line of pharmacologic therapy, but dopamine- receptor–blocking drugs are required for multiple, complex tics. Dopamine-receptor–blocking drugs are associated with potential side effects including sedation, weight gain, acute dystonic reactions, and tardive dyskinesia. Appropriate diagnosis and treatment can substantially improve quality of life and psychosocial functioning in affected children. (Am Fam Physician. 2008;77(5):651-658, 659-660. Copyright © 2008 American Academy of Family Physicians.) ▲ Patient information: n 1885, Georges Gilles de la Tourette normal context or in inappropriate situa- A handout on Tourette’s described the major clinical features tions, thus calling attention to the person syndrome, written by the authors of this article, is of the syndrome that now carries his because of their exaggerated, forceful, and provided on p. -
Tourette's Syndrome: a Review from a Developmental Perspective
Isr J Psychiatry Relat Sci - Vol. 47 - No 2 (2010) Tourette's Syndrome: A Review from a Developmental Perspective Tamar Steinberg, MD, 1 Robert King, MD, 2 and Alan Apter, MD 1 1 The Harry Freund Neuro-Psychiatric Clinic, Schneider Children's Medical Center, Petah Tikva, Israel 2 Yale Child Study Center, New Haven, Connecticut, U.S.A. izations. Simple motor tics are sudden, fleeting or ABSTRACT fragmentary movements such as blinking, grimacing, head jerking, or shoulder shrugs. Complex motor tics The object of this review is to summarize some of the consist of several simple motor tics occurring in an recent developments in the understanding of Tourette’s orchestrated sequence or semi-purposeful movements, Syndrome which can be regarded as the prototype of a such as touching or tapping; these may also have a more developmental psychopathological entity. The review sustained, twisting, and dystonic character (2). covers the following topics: tics and their developmental Simple phonic tics consist of simple, unarticulated course; sensory phenomena related to tics including sounds such as throat clearing, sniffing, grunting, measurement of these phenomena; pathophysiology squeaking, or coughing. Complex phonic tics consist of of tics and compensatory phenomena and the parallel out-of-context syllables, words, phrases or paroxysmal development of the various psychiatric comorbidities as changes of prosody. they emerge over the life span. Finally there is an attempt Complex tics may involve socially inappropriate or to summarize the major points and future directions. obscene gestures (copropraxia) or utterances (coprola- lia), as well as echo phenomena, such as echolalia or echopraxia (repeating others’ words or gestures), which exemplify the suggestibility of tics. -
Ziprasidone Monotherapy for Tourette Syndrome with Comorbid ADHD
f Ps al o ych rn ia u tr o y J Journal of Psychiatry Naguy and At-Tajali, J Psychiatry 2015, S1 DOI: 10.4172/2378-5756..S1-002 ISSN: 2378-5756 ShortResearch Communication Article OpenOpen Access Access Ziprasidone Monotherapy for Tourette Syndrome with Comorbid ADHD Ahmed Naguy1* and Ali At-Tajali2 1Child and Adolescent Psychiatrist, Kuwait Centre for Mental Health (KCMH), Kuwait 2General Adult Psychiatrist, Head of Neuromodulation Unit, KCMH, Kuwait Abbreviations: TS: de la Tourette Syndrome; OCD: Obsessive- There is no hard and fast rule, but antipsychotics, especially atypical Compulsive Disorder; PANDAS: Paediatric Autoimmune (AAPs), by and large, produce the most robust results controlling tics Neuropsychiatric Disorders Associated with Streptococcal Infection; when socially-embarrassing or functionally impairing. Nonetheless, ADHD: Attention-Deficit/Hyperactivity Disorder; AAP: Atypical clinicians ’enthusiasm is commonly tempered by the ominous Antipsychotics; ECG: Electrocardiogram; OPD: Outpatient metabolic and/or neurologic syndromes subsequent to antipsychotic Department; HRT: Habit Reversal Therapy; Y-GTSS: Yale-Global use. Pharmacologic options for TS are legion [11] (Table 4). Tic Severity Scale; IQ: Intelligence Quotient; DSST: Digital Symbol Here, we are reporting a case of adolescent TS with comorbid Substitution Test; CPT: Continuous Performance Test. severe ADHD where stimulants were deleterious for tics, atomoxetine (Strattera®) was ineffective addressing ADHD, and clonidine (Catapres®) Short Communication was too soporific -
Tourette Syndrome in Children
Focus | Clinical Tourette syndrome in children Valsamma Eapen, Tim Usherwood UP TO 20% OF CHILDREN exhibit rapid jerky peak severity at the age of approximately movements (motor tics) that are made 10–12 years, and typically improve by without conscious intention as part of a adolescence or thereafter.6 Background Gilles de la Tourette syndrome (GTS), developmental phase that often lasts a few 1 characterised by motor and vocal tics, weeks to months. Similarly, involuntary has a prevalence of approximately 1% sounds, vocalisations or noises (vocal or Clinical features in school-aged children. Commonly phonic tics) such as coughing and even In addition to simple motor and vocal/ encountered comorbidities of GTS brief screams or shouts may be observed in phonic tics, complex tics may be present include attention deficit hyperactivity some children for brief periods of time. Tics (Table 1). Some complex tics – such as disorder (ADHD) and obsessive- lasting for a few weeks to months are known spitting, licking, kissing, etc – may be compulsive behaviour/disorder (OCB/ OCD). Genetic factors play an important as ‘transient tic disorder’. When single misunderstood or misinterpreted and part in the aetiology of GTS, and family or multiple motor or vocal tics – but not a may result in the young person getting members may exhibit tics or related combination of both – have been present in trouble, especially if these tics include disorders such as ADHD, OCB or OCD. for more than one year, the term ‘chronic involuntary and inappropriate obscene tic disorder’ is used. When both (multiple) gesturing (copropraxia) or copying the Objective The aim of this article is to present a motor and (one or more) vocal tics have been movements of other people (echopraxia). -
Sensory Phenomena Related to Tics, Obsessive-Compulsive Symptoms
Available online at www.sciencedirect.com ScienceDirect Comprehensive Psychiatry 62 (2015) 141–146 www.elsevier.com/locate/comppsych Sensory phenomena related to tics, obsessive-compulsive symptoms, and global functioning in Tourette syndrome ⁎ Yukiko Kanoa, , Natsumi Matsudab, Maiko Nonakab, Miyuki Fujioc, Hitoshi Kuwabarad, Toshiaki Konoe aDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-8655, Japan bDepartment of Child Psychiatry, The University of Tokyo Hospital, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-8655, Japan cCourse of Clinical Psychology, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-0033, Japan dDisability Services Office, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-0033, Japan eDepartment of Forensic Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira-shi, Tokyo 187-8551, Japan Abstract Objectives: Sensory phenomena, including premonitory urges, are experienced by patients with Tourette syndrome (TS) and obsessive- compulsive disorder (OCD). The goal of the present study was to investigate such phenomena related to tics, obsessive-compulsive symptoms (OCS), and global functioning in Japanese patients with TS. Methods: Forty-one patients with TS were assessed using the University of São Paulo Sensory Phenomena Scale (USP-SPS), the Premonitory Urge for Tics Scale (PUTS), the Yale Global Tic Severity Scale (YGTSS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), and the Global Assessment of Functioning (GAF) Scale. Results: USP-SPS and PUTS total scores were significantly correlated with YGTSS total and vocal tics scores. -
Tourette Syndrome and Tic Disorders
Tourette Syndrome and Tic Disorders Presentation by Kiran Singh, PGY-3 UCI/CHOC Pediatrics Residency Program Case 1: Leslie ● 8 year old previously healthy female. At age 6, she started developing involuntary blinking and head jerking. These movements will sometimes recede for a couple of weeks but then reappear without any known triggers. She has a family history of generalized anxiety disorder in mom, OCD in dad. She is not on any medications currently. Otherwise, she is doing well in school, and has been told she has “above average intelligence. Mom does, however, report that she has “an anxious temperament.” What is her diagnosis? Case 2: Benjamin ● 11 year old with history of inattention and hyperactivity presenting with a history of throat clearing since age 10, with grimacing and shoulder shrugging. Mom is frustrated with his behavior, saying “first he wouldn’t stop disrupting class by clearing his throat loudly, which finally got better over the last few weeks, but now he’s starting to make grunting sounds!” Benjamin says he can’t control these actions, that he just has an urge to them and feels better after doing them. He otherwise is not on any medications. His brother has a history of ADHD. What is his diagnosis? Tic Disorders: DSM V diagnoses ● Tourette’s disorder: the presence of both motor and vocal tics for more than 1 year (Case 2: Benjamin) ● Persistent (chronic) motor or vocal tic disorder: single or multiple motor or vocal tics for more than 1 year, but not both motor and vocal (Case 1: Leslie) ● Provisional tic disorder -
Tourette Syndrome— Much More Than Tics Moving Beyond Misconceptions to a Diagnosis
Cover article LOWELL HANDLER First of two parts Tourette syndrome— much more than tics Moving beyond misconceptions to a diagnosis By Samuel H. Zinner, MD Far more people have heard of Tourette syndrome than know what it actually looks and sounds like—or how it feels to the person who has it. That’s a major reason the diagnosis of this condition—the most severe tic disorder—is often missed. A change of perception begins with understanding the breadth and variability of symptoms and being aware of comorbidity. ore than a century has passed since the ical figures (including the Roman Emperor Claudius, French neurologist Georges Gilles de la Wolfgang Amadeus Mozart, and 18th century English Tourette first described the condition literary scholar Samuel Johnson) testify to the wide- that bears his name, a name familiar to spread awareness of TS across cultures and time, de- the lay public and health professionals spite (or perhaps because of) its perceived rarity. So it alike. Once considered so rare that neurologists might seems that the medical community trailed the un- Mexpect to witness the disorder perhaps once in their trained community by centuries in recognizing the professional lifetime, Tourette syndrome (TS) is, in syndrome. fact, common enough that virtually all pediatricians From the time of its initial medical description in will have several patients with this condition in their 1885 until the 1960s, medical experts viewed TS as a practice. Yet, despite its name recognition and the psychological disorder, and treatment was customarily number of people it affects, TS often goes undiag- directed toward psychotherapy. -
Pediatric Autoimmune Neuropsychiatric Disorder
Research Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS): Clinical Manifestations, IVIG Treatment Outcomes, Results from a Cohort of Italian Patients Piero Pavone1, Raffaele Falsaperla1, Francesco Nicita2, Andreana Zecchini3, Chiara Battaglia1, Alberto Spalice 2, Lucia Iozzi3, Enrico Parano4, Giovanna Vitaliti1, Alberto Verrotti5, Vincenzo Belcastro6, Sung Yoon Cho7,†, Dong-Kyu Jin7, Salvatore Savasta3 Abstract Pediatric Autoimmune Neuropsychiatric Disorder associated with Streptococcal Infection (PANDAS) is characterized with main clinical features including obsessive-compulsive disorders and tics, acute-onset in prepubertal age, relapsing-remitting course, association with neurological abnormalities (mainly choreiform movements and motor hyperactivity), and temporal relationship with group A streptococcal infections. Thirty- four children with a serious- severe grade of PANDAS were enrolled in Italian Institutions with the aim to report clinical manifestations of the patients and their response to the intravenous immunoglobulin (IVIG) treatment. All patients were selected according to the Swedo‘s criteria and specific laboratory investigations as suggested by Chang for the PANS and treated with IVIG at the dosage of 2 g/kg/day for two consecutive days. At the onset, all patients presented with at least, one psychiatric manifestation including anxiety, emotional lability, bedwetting, enuresis, and phobia, and oppositional behavior including temper tantrums, personality changes, and deterioration in math skills and handwriting. At the laboratory investigations, positivity of pharyngeal swab for streptococcal infection in most of the patients and variable titers of anti-DNase B and ASO were found. In 29 patients reduction or disappearing of the motor symptoms were reached after 1 or 2 cycles of IVIG treatment, while in 5 patients the symptoms reappeared after the third cycle of IVIG. -
Eye Movement Measures of Cognitive Control in Children with Tourette Syndrome
The Texas Medical Center Library DigitalCommons@TMC The University of Texas MD Anderson Cancer Center UTHealth Graduate School of The University of Texas MD Anderson Cancer Biomedical Sciences Dissertations and Theses Center UTHealth Graduate School of (Open Access) Biomedical Sciences 5-2010 Eye Movement Measures of Cognitive Control in Children with Tourette Syndrome Cameron B. Jeter Follow this and additional works at: https://digitalcommons.library.tmc.edu/utgsbs_dissertations Part of the Cognitive Neuroscience Commons, Nervous System Diseases Commons, Other Psychiatry and Psychology Commons, and the Systems Neuroscience Commons Recommended Citation Jeter, Cameron B., "Eye Movement Measures of Cognitive Control in Children with Tourette Syndrome" (2010). The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access). 26. https://digitalcommons.library.tmc.edu/utgsbs_dissertations/26 This Dissertation (PhD) is brought to you for free and open access by the The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences at DigitalCommons@TMC. It has been accepted for inclusion in The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access) by an authorized administrator of DigitalCommons@TMC. For more information, please contact [email protected]. EYE MOVEMENT MEASURES OF COGNITIVE CONTROL IN CHILDREN WITH TOURETTE SYNDROME by Cameron Beth -
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children with Tourette Syndrome
ARTICLE Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome Michael H. Bloch, BA; Bradley S. Peterson, MD; Lawrence Scahill, MSN, PhD; Jessica Otka, BA; Lily Katsovich, MS; Heping Zhang, PhD; James F. Leckman, MD Background: Tourette syndrome (TS) is a childhood- Main Outcome Measures: Expert-rated tic and OCD onset neuropsychiatric disorder that is characterized by symptom severity at follow-up interview an average of both motor and phonic tics. One half to two thirds of chil- 7.6 years later (range, 3.8-12.8 years). dren with TS experience a reduction or complete reso- lution of tic symptoms during adolescence. At least one Results: Eighty-five percent of subjects reported a re- third of adults with TS have comorbid obsessive- duction in tic symptoms during adolescence. Only in- compulsive disorder (OCD). creased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst- Objectives: To clarify the clinical course of tic and OCD ever tic severity was 10.6 years. Forty-one percent of pa- symptoms in children with TS and determine if baseline tients with TS reported at one time experiencing at least clinical measurements in childhood are associated with moderate OCD symptoms. Worst-ever OCD symptoms future symptom severity in late adolescence and early occurred approximately 2 years later than worst-ever tic adulthood. symptoms. Increased childhood IQ was strongly associ- ated with increased OCD severity at follow-up. Design: Prospective cohort study. Conclusion: Obsessive-compulsive disorder symp- Setting: Yale Child Study Center tic and OCD outpa- tient specialty clinic.