Tic Disorders
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Inositol Safety: Clinical Evidences
European Review for Medical and Pharmacological Sciences 2011; 15: 931-936 Inositol safety: clinical evidences G. CARLOMAGNO, V. UNFER AGUNCO Obstetrics & Gynecology Center, Rome (Italy) Abstract. – Myo-inositol is a six carbon ent required by the human cells for the growth cyclitol that contains five equatorial and one axi- and survival in the culture. In humans and other al hydroxyl groups. Myo-inositol has been classi- species, Myo-inositol can be converted to either fied as an insulin sensitizing agent and it is L- or D-chiro-inositol by epimerases. Early stud- commonly used in the treatment of the Polycys- tic Ovary Syndrome (PCOS). However, despite ies showed that inositol urinary clearance was al- its wide clinical use, there is still scarce informa- tered in type 2 diabetes patients, the next step tion on the myo-inositol safety and/or side ef- was to link impaired inositol clearance with in- fects. The aim of the present review was to sum- sulin resistance (for a review see1). Because of marize and discuss available data on the myo-in- these properties, inositol have been classified as ositol safety both in non-clinical and clinical set- “insulin sensitizing agent”2. tings. The main outcome was that only the highest In the recent years, inositol has found more dose of myo-inositol (12 g/day) induced mild and more space in the reproductive clinical prac- gastrointestinal side effects such as nausea, fla- tice3-6. Indeed, since the main therapy for Poly- tus and diarrhea. The severity of side effects did cystic Ovary Syndrome (PCOS) is the use of in- not increase with the dosage. -
Anxiety Disorders in Children Revised 2020
Information about: Anxiety Disorders in Children Revised 2020 Vermont Family Network 600 Blair Park Road, Ste 240 Williston, VT 05495 1-800-800-4005 www.VermontFamilyNetwork.org Introduction According to The Child Mind Institute, “Children with anxiety disorders are overwhelmed by feelings of intense fear or worry that they are out of proportion to the situation or thing that triggers them. These emotional fears can be focused on separating from parents, physical illness, performing poorly, or embarrassing themselves. Or they can be attached to specific things, like dogs or insects or bridges.” We hope that this will give you a greater understanding of anxiety disorders and the ways that parents and professionals can support children at home, in school, and in the community. We have selected information from various sources and provided internet links when possible. The information we have presented was used by permission from various sources. We have provided links for you to find more, in-depth information at their sites. Contents Title Page Anxiety Disorders in Children and Adolescents 2 Additional Treatments and Guidance 2 The Anxious Child 3 Anxiety Quick Fact Sheet for School Personnel & 4 Parents/Guardians Children Who Won’t Go to School (Separation Anxiety) 6 Managing Anxiety with Siblings 6 Panic Disorder in Children and Adolescents 7 Parenting Tips for Anxious Kids 8 Getting Linked (local resources) 9 Advocating for Your Child: 25 Tips for Parents 10-12 Resources 13 Anxiety Disorders in Children and Adolescents What Are Anxiety Disorders? According to The National Alliance on Mental Illness (NAMI)*, “Anxiety disorders are the most common mental health concern in the United States. -
OCD Bingo Instructions
OCD Bingo Instructions Host Instructions: · Decide when to start and select your goal(s) · Designate a judge to announce events · Cross off events from the list below when announced Goals: · First to get any line (up, down, left, right, diagonally) · First to get any 2 lines · First to get the four corners · First to get two diagonal lines through the middle (an "X") · First to get all squares (a "coverall") Guest Instructions: · Check off events on your card as the judge announces them · If you satisfy a goal, announce "BINGO!". You've won! · The judge decides in the case of disputes This is an alphabetical list of all 29 events: Anxiety, Aviator, Brain, C.B.T., Clomipramine, Comorbidity, Compulsions, Counting, Cyclical, Hand-washing, Hepburn, History, Hughes, Indirect pathway, O.C.D., O.C.P.D., Obsessions, Persistent, Plane crash, Psychology, Recurrent, Screen Room, Scrupulosity, Stress, Tic Disorder, Washing, Y-BOCS, Zwangsneurose, phlebotomy. BuzzBuzzBingo.com · Create, Download, Print, Play, BINGO! · Copyright © 2003-2021 · All rights reserved OCD Bingo Call Sheet This is a randomized list of all 29 bingo events in square format that you can mark off in order, choose from randomly, or cut up to pull from a hat: Stress C.B.T. Hughes Hand-washing Aviator Tic Washing Obsessions O.C.D. Persistent Disorder Screen Psychology phlebotomy O.C.P.D. Scrupulosity Room Plane Compulsions Counting Zwangsneurose Comorbidity crash Clomipramine Y-BOCS Anxiety History Hepburn Indirect Cyclical Brain Recurrent pathway BuzzBuzzBingo.com · Create, Download, Print, Play, BINGO! · Copyright © 2003-2021 · All rights reserved B I N G O Screen Brain History Y-BOCS Aviator Room Zwangsneurose Hughes phlebotomy Persistent Anxiety Plane C.B.T. -
Tourette's Syndrome
Tourette’s Syndrome CHRISTOPHER KENNEY, MD; SHENG-HAN KUO, MD; and JOOHI JIMENEZ-SHAHED, MD Baylor College of Medicine, Houston, Texas Tourette’s syndrome is a movement disorder most commonly seen in school-age children. The incidence peaks around preadolescence with one half of cases resolving in early adult- hood. Tourette’s syndrome is the most common cause of tics, which are involuntary or semi- voluntary, sudden, brief, intermittent, repetitive movements (motor tics) or sounds (phonic tics). It is often associated with psychiatric comorbidities, mainly attention-deficit/hyperac- tivity disorder and obsessive-compulsive disorder. Given its diverse presentation, Tourette’s syndrome can mimic many hyperkinetic disorders, making the diagnosis challenging at times. The etiology of this syndrome is thought to be related to basal ganglia dysfunction. Treatment can be behavioral, pharmacologic, or surgical, and is dictated by the most incapacitating symp- toms. Alpha2-adrenergic agonists are the first line of pharmacologic therapy, but dopamine- receptor–blocking drugs are required for multiple, complex tics. Dopamine-receptor–blocking drugs are associated with potential side effects including sedation, weight gain, acute dystonic reactions, and tardive dyskinesia. Appropriate diagnosis and treatment can substantially improve quality of life and psychosocial functioning in affected children. (Am Fam Physician. 2008;77(5):651-658, 659-660. Copyright © 2008 American Academy of Family Physicians.) ▲ Patient information: n 1885, Georges Gilles de la Tourette normal context or in inappropriate situa- A handout on Tourette’s described the major clinical features tions, thus calling attention to the person syndrome, written by the authors of this article, is of the syndrome that now carries his because of their exaggerated, forceful, and provided on p. -
Cognitive-Behavioural Therapy of Obsessive- Compulsive Disorder
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Veterinary medicine - Repository of PHD, master's thesis UNIVERSITY OF ZAGREB SCHOOL OF MEDICINE Veronika Nives Zoric Cognitive-Behavioural Therapy of Obsessive- Compulsive Disorder GRADUATE THESIS Zagreb, 2017. This graduate thesis was made at the Department of Psychiatry KBC Zagreb, University of Zagreb School of Medicine, mentored by prof. dr. sc. Dražen Begić and was submitted for evaluation in the 2016/2017 academic year. Mentor: prof. dr. sc. Dražen Begić ABBREVIATIONS USED IN THE TEXT: Behaviour Therapy (BT) Bibliotherapy administered CBT (bCBT) Cognitive-Behavioural Therapy (CBT) Cognitive Therapy (CT) Computerized CBT (cCBT) Danger Ideation Reduction Therapy (DIRT) Deep Brain Stimulation (DBS) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Exposure and Response Prevention (ERP) Generalized Anxiety Disorder (GAD) International Classification of Disease (ICD-10) Internet-administered CBT (iCBT) Major Depressive Disorder (MDD) Monoamine Oxidase Inhibitors (MAO) Obsessive-Compulsive Disorder (OCD) Obsessive-Compulsive Personality Disorder (OCPD) Selective Serotonin Reuptake Inhibitor (SSRI) Serotonin; 5-hydroxytryptamine (5HT) Serotonin Reuptake Inhibitor (SRI) Subjective Units of Distress Scale (SUDS) Telephone administered CBT (tCBT) Tricyclic Antidepressants (TCA) Videoconferencing administered CBT (vCBT) Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) TABLE OF CONTENTS 1. SUMMARY 2. SAŽETAK 3. INTRODUCTION ............................................................................................................ -
Sensory Phenomena Related to Tics, Obsessive-Compulsive Symptoms
Available online at www.sciencedirect.com ScienceDirect Comprehensive Psychiatry 62 (2015) 141–146 www.elsevier.com/locate/comppsych Sensory phenomena related to tics, obsessive-compulsive symptoms, and global functioning in Tourette syndrome ⁎ Yukiko Kanoa, , Natsumi Matsudab, Maiko Nonakab, Miyuki Fujioc, Hitoshi Kuwabarad, Toshiaki Konoe aDepartment of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-8655, Japan bDepartment of Child Psychiatry, The University of Tokyo Hospital, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-8655, Japan cCourse of Clinical Psychology, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-0033, Japan dDisability Services Office, The University of Tokyo, 7-3-1 Hongo, Bukyo-ku, Tokyo 113-0033, Japan eDepartment of Forensic Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira-shi, Tokyo 187-8551, Japan Abstract Objectives: Sensory phenomena, including premonitory urges, are experienced by patients with Tourette syndrome (TS) and obsessive- compulsive disorder (OCD). The goal of the present study was to investigate such phenomena related to tics, obsessive-compulsive symptoms (OCS), and global functioning in Japanese patients with TS. Methods: Forty-one patients with TS were assessed using the University of São Paulo Sensory Phenomena Scale (USP-SPS), the Premonitory Urge for Tics Scale (PUTS), the Yale Global Tic Severity Scale (YGTSS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), and the Global Assessment of Functioning (GAF) Scale. Results: USP-SPS and PUTS total scores were significantly correlated with YGTSS total and vocal tics scores. -
Tourette Syndrome and Tic Disorders
Tourette Syndrome and Tic Disorders Presentation by Kiran Singh, PGY-3 UCI/CHOC Pediatrics Residency Program Case 1: Leslie ● 8 year old previously healthy female. At age 6, she started developing involuntary blinking and head jerking. These movements will sometimes recede for a couple of weeks but then reappear without any known triggers. She has a family history of generalized anxiety disorder in mom, OCD in dad. She is not on any medications currently. Otherwise, she is doing well in school, and has been told she has “above average intelligence. Mom does, however, report that she has “an anxious temperament.” What is her diagnosis? Case 2: Benjamin ● 11 year old with history of inattention and hyperactivity presenting with a history of throat clearing since age 10, with grimacing and shoulder shrugging. Mom is frustrated with his behavior, saying “first he wouldn’t stop disrupting class by clearing his throat loudly, which finally got better over the last few weeks, but now he’s starting to make grunting sounds!” Benjamin says he can’t control these actions, that he just has an urge to them and feels better after doing them. He otherwise is not on any medications. His brother has a history of ADHD. What is his diagnosis? Tic Disorders: DSM V diagnoses ● Tourette’s disorder: the presence of both motor and vocal tics for more than 1 year (Case 2: Benjamin) ● Persistent (chronic) motor or vocal tic disorder: single or multiple motor or vocal tics for more than 1 year, but not both motor and vocal (Case 1: Leslie) ● Provisional tic disorder -
Tourette Syndrome— Much More Than Tics Moving Beyond Misconceptions to a Diagnosis
Cover article LOWELL HANDLER First of two parts Tourette syndrome— much more than tics Moving beyond misconceptions to a diagnosis By Samuel H. Zinner, MD Far more people have heard of Tourette syndrome than know what it actually looks and sounds like—or how it feels to the person who has it. That’s a major reason the diagnosis of this condition—the most severe tic disorder—is often missed. A change of perception begins with understanding the breadth and variability of symptoms and being aware of comorbidity. ore than a century has passed since the ical figures (including the Roman Emperor Claudius, French neurologist Georges Gilles de la Wolfgang Amadeus Mozart, and 18th century English Tourette first described the condition literary scholar Samuel Johnson) testify to the wide- that bears his name, a name familiar to spread awareness of TS across cultures and time, de- the lay public and health professionals spite (or perhaps because of) its perceived rarity. So it alike. Once considered so rare that neurologists might seems that the medical community trailed the un- Mexpect to witness the disorder perhaps once in their trained community by centuries in recognizing the professional lifetime, Tourette syndrome (TS) is, in syndrome. fact, common enough that virtually all pediatricians From the time of its initial medical description in will have several patients with this condition in their 1885 until the 1960s, medical experts viewed TS as a practice. Yet, despite its name recognition and the psychological disorder, and treatment was customarily number of people it affects, TS often goes undiag- directed toward psychotherapy. -
The Course and Clinical Features of Obsessive Compulsive Disorder
111 THE COURSE AND CLINICAL FEATURES OF OBSESSIVE- COMPULSIVE DISORDER STEVEN A. RASMUSSEN JANE L. EISEN Twenty years have passed since the landmark National Epi- to 3% of the general population in the United States meet demiology Catchment Area Survey first demonstrated the lifetime DSM criteria for OCD (4). In a World Health prevalence of obsessive-compulsive disorder (OCD) in the Organization study that determined the leading causes of general population to be 50 to 100 times greater than had mortality and morbidity in developed countries, OCDwas been previously believed (1). This unexpected finding was found to be the eighth leading cause of disability for any instrumental in the renewed interest in and rapid growth of medical or psychiatric condition for ages 15 through 44 (5). our understanding of the clinical features, pathophysiology, Total costs of the disorder in the United States have been and treatment of OCD. Epidemiologic studies in different estimated at $8 billion in 1990, including $2.1 billion in cultures have confirmed the findings that up to 1% to 2% of direct costs and $5.9 billion in indirect costs related to lost the general population worldwide suffer from the disorder at productivity (6). any given time (2). Widespread attention in the media, in However, despite the increased recognition of the public addition to growing recognition of the disorder among health significance of OCDduring the last decade, surpris- health care professionals, has resulted in improvements in ingly little is known about the long-term course and prog- the diagnosis and treatment of large numbers of patients nosis of the disorder. -
5-HT2A Receptors in the Central Nervous System the Receptors
The Receptors Bruno P. Guiard Giuseppe Di Giovanni Editors 5-HT2A Receptors in the Central Nervous System The Receptors Volume 32 Series Editor Giuseppe Di Giovanni Department of Physiology & Biochemistry Faculty of Medicine and Surgery University of Malta Msida, Malta The Receptors book Series, founded in the 1980’s, is a broad-based and well- respected series on all aspects of receptor neurophysiology. The series presents published volumes that comprehensively review neural receptors for a specific hormone or neurotransmitter by invited leading specialists. Particular attention is paid to in-depth studies of receptors’ role in health and neuropathological processes. Recent volumes in the series cover chemical, physical, modeling, biological, pharmacological, anatomical aspects and drug discovery regarding different receptors. All books in this series have, with a rigorous editing, a strong reference value and provide essential up-to-date resources for neuroscience researchers, lecturers, students and pharmaceutical research. More information about this series at http://www.springer.com/series/7668 Bruno P. Guiard • Giuseppe Di Giovanni Editors 5-HT2A Receptors in the Central Nervous System Editors Bruno P. Guiard Giuseppe Di Giovanni Faculté de Pharmacie Department of Physiology Université Paris Sud and Biochemistry Université Paris-Saclay University of Malta Chatenay-Malabry, France Msida MSD, Malta Centre de Recherches sur la Cognition Animale (CRCA) Centre de Biologie Intégrative (CBI) Université de Toulouse; CNRS, UPS Toulouse, France The Receptors ISBN 978-3-319-70472-2 ISBN 978-3-319-70474-6 (eBook) https://doi.org/10.1007/978-3-319-70474-6 Library of Congress Control Number: 2017964095 © Springer International Publishing AG 2018 This work is subject to copyright. -
Pediatric Autoimmune Neuropsychiatric Disorder
Research Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection (PANDAS): Clinical Manifestations, IVIG Treatment Outcomes, Results from a Cohort of Italian Patients Piero Pavone1, Raffaele Falsaperla1, Francesco Nicita2, Andreana Zecchini3, Chiara Battaglia1, Alberto Spalice 2, Lucia Iozzi3, Enrico Parano4, Giovanna Vitaliti1, Alberto Verrotti5, Vincenzo Belcastro6, Sung Yoon Cho7,†, Dong-Kyu Jin7, Salvatore Savasta3 Abstract Pediatric Autoimmune Neuropsychiatric Disorder associated with Streptococcal Infection (PANDAS) is characterized with main clinical features including obsessive-compulsive disorders and tics, acute-onset in prepubertal age, relapsing-remitting course, association with neurological abnormalities (mainly choreiform movements and motor hyperactivity), and temporal relationship with group A streptococcal infections. Thirty- four children with a serious- severe grade of PANDAS were enrolled in Italian Institutions with the aim to report clinical manifestations of the patients and their response to the intravenous immunoglobulin (IVIG) treatment. All patients were selected according to the Swedo‘s criteria and specific laboratory investigations as suggested by Chang for the PANS and treated with IVIG at the dosage of 2 g/kg/day for two consecutive days. At the onset, all patients presented with at least, one psychiatric manifestation including anxiety, emotional lability, bedwetting, enuresis, and phobia, and oppositional behavior including temper tantrums, personality changes, and deterioration in math skills and handwriting. At the laboratory investigations, positivity of pharyngeal swab for streptococcal infection in most of the patients and variable titers of anti-DNase B and ASO were found. In 29 patients reduction or disappearing of the motor symptoms were reached after 1 or 2 cycles of IVIG treatment, while in 5 patients the symptoms reappeared after the third cycle of IVIG. -
Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children with Tourette Syndrome
ARTICLE Adulthood Outcome of Tic and Obsessive-Compulsive Symptom Severity in Children With Tourette Syndrome Michael H. Bloch, BA; Bradley S. Peterson, MD; Lawrence Scahill, MSN, PhD; Jessica Otka, BA; Lily Katsovich, MS; Heping Zhang, PhD; James F. Leckman, MD Background: Tourette syndrome (TS) is a childhood- Main Outcome Measures: Expert-rated tic and OCD onset neuropsychiatric disorder that is characterized by symptom severity at follow-up interview an average of both motor and phonic tics. One half to two thirds of chil- 7.6 years later (range, 3.8-12.8 years). dren with TS experience a reduction or complete reso- lution of tic symptoms during adolescence. At least one Results: Eighty-five percent of subjects reported a re- third of adults with TS have comorbid obsessive- duction in tic symptoms during adolescence. Only in- compulsive disorder (OCD). creased tic severity in childhood was associated with increased tic severity at follow-up. The average age at worst- Objectives: To clarify the clinical course of tic and OCD ever tic severity was 10.6 years. Forty-one percent of pa- symptoms in children with TS and determine if baseline tients with TS reported at one time experiencing at least clinical measurements in childhood are associated with moderate OCD symptoms. Worst-ever OCD symptoms future symptom severity in late adolescence and early occurred approximately 2 years later than worst-ever tic adulthood. symptoms. Increased childhood IQ was strongly associ- ated with increased OCD severity at follow-up. Design: Prospective cohort study. Conclusion: Obsessive-compulsive disorder symp- Setting: Yale Child Study Center tic and OCD outpa- tient specialty clinic.