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Product Data Sheet Product data sheet MedKoo Cat#: 317118 Name: Eliprodil CAS#: 119431-25-3 Chemical Formula: C20H23ClFNO Exact Mass: 347.14522 Molecular Weight: 347.86 Product supplied as: Powder Purity (by HPLC): ≥ 98% Shipping conditions Ambient temperature Storage conditions: Powder: -20°C 3 years; 4°C 2 years. In solvent: -80°C 3 months; -20°C 2 weeks. 1. Product description: Eliprodil, aslo known as SL-82,0715; is a NMDA antagonist. NMDA receptors are a key component in mediating glutamate-induced excitotoxicity, and it is believed that NMDA antagonists would be neuroprotective after a stroke or other traumatic brain injury. Eliprodil protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Eliprodil stimulates CNS myelination, may be a new prospect for multiple sclerosis. 2. CoA, QC data, SDS, and handling instruction SDS and handling instruction, CoA with copies of QC data (NMR, HPLC and MS analytical spectra) can be downloaded from the product web page under “QC And Documents” section. Note: copies of analytical spectra may not be available if the product is being supplied by MedKoo partners. Whether the product was made by MedKoo or provided by its partners, the quality is 100% guaranteed. 3. Solubility data Solvent Max Conc. mg/mL Max Conc. mM DMSO 11.25 32.34 DMF 10.0 28.75 Ethanol 4.0 11.50 4. Stock solution preparation table: Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg 1 mM 2.87 mL 14.37 mL 28.75 mL 5 mM 0.57 mL 2.87 mL 5.75 mL 10 mM 0.29 mL 1.44 mL 2.87 mL 50 mM 0.06 mL 0.29 mL 0.57 mL 5. Molarity Calculator, Reconstitution Calculator, Dilution Calculator Please refer the product web page under section of “Calculator” 6. Recommended literature which reported protocols for in vitro and in vivo study In vitro study 1. Demerens C, Stankoff B, Zalc B, Lubetzki C. Eliprodil stimulates CNS myelination: new prospects for multiple sclerosis? Neurology. 1999 Jan 15;52(2):346-50. doi: 10.1212/wnl.52.2.346. PMID: 9932955. 2. Reyes M, Reyes A, Opitz T, Kapin MA, Stanton PK. Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Brain Res. 1998 Jan 26;782(1-2):212-8. doi: 10.1016/s0006- 8993(97)01280-8. PMID: 9519265. In vivo study 1. Lengyel C, Dézsi L, Biliczki P, Horváth C, Virág L, Iost N, Németh M, Tálosi L, Papp JG, Varró A. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143(1):152-8. doi: 10.1038/sj.bjp.0705901. Epub 2004 Aug 9. PMID: 15302678; PMCID: PMC1575264. 2. Thomas JD, Garcia GG, Dominguez HD, Riley EP. Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology (Berl). 2004 Sep;175(2):189-95. doi: 10.1007/s00213-004-1806-x. Epub 2004 Apr 3. PMID: 15064913. MedKoo Biosciences || http://www.medkoo.com || [email protected] 2500 Gateway Centre Blvd Suite 400, Morrisville, NC27560, USA. Tel: 919-636-5577, Fax: 919-980-4831 Product data sheet 7. Bioactivity Biological target: Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM). In vitro activity Under both culture conditions, addition of 10(-6) M eliprodil did not modify significantly the total number of either microtubule associated protein-2-positive neurons or MBP-positive oligodendrocytes. However, eliprodil induced a twofold (p < 0.01) increase in myelination when added to B-S medium, and a 4.7-fold (p < 0.0001) increase when added to D medium. Reference: Neurology. 1999 Jan 15;52(2):346-50. https://pubmed.ncbi.nlm.nih.gov/9932955/ In vivo activity Newman-Keuls follow-up tests demonstrated that the ethanol-exposed rats treated with 5 mg/kg eliprodil committed statistically significantly fewer errors compared to ethanol subjects treated with vehicle. Reference: Psychopharmacology (Berl). 2004 Sep;175(2):189-95. https://pubmed.ncbi.nlm.nih.gov/15064913/ Note: The information listed here was extracted from literature. MedKoo has not independently retested and confirmed the accuracy of these methods. Customer should use it just for a reference only. MedKoo Biosciences || http://www.medkoo.com || [email protected] 2500 Gateway Centre Blvd Suite 400, Morrisville, NC27560, USA. Tel: 919-636-5577, Fax: 919-980-4831 .
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