Helicobacter Trogontum Sp. Nov., Isolated from the Rat Intestine EDILBERTO N
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Food Or Beverage Product, Or Probiotic Composition, Comprising Lactobacillus Johnsonii 456
(19) TZZ¥¥¥ _T (11) EP 3 536 328 A1 (12) EUROPEAN PATENT APPLICATION (43) Date of publication: (51) Int Cl.: 11.09.2019 Bulletin 2019/37 A61K 35/74 (2015.01) A61K 35/66 (2015.01) A61P 35/00 (2006.01) (21) Application number: 19165418.5 (22) Date of filing: 19.02.2014 (84) Designated Contracting States: • SCHIESTL, Robert, H. AL AT BE BG CH CY CZ DE DK EE ES FI FR GB Encino, CA California 91436 (US) GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO • RELIENE, Ramune PL PT RO RS SE SI SK SM TR Los Angeles, CA California 90024 (US) • BORNEMAN, James (30) Priority: 22.02.2013 US 201361956186 P Riverside, CA California 92506 (US) 26.11.2013 US 201361909242 P • PRESLEY, Laura, L. Santa Maria, CA California 93458 (US) (62) Document number(s) of the earlier application(s) in • BRAUN, Jonathan accordance with Art. 76 EPC: Tarzana, CA California 91356 (US) 14753847.4 / 2 958 575 (74) Representative: Müller-Boré & Partner (71) Applicant: The Regents of the University of Patentanwälte PartG mbB California Friedenheimer Brücke 21 Oakland, CA 94607 (US) 80639 München (DE) (72) Inventors: Remarks: • YAMAMOTO, Mitsuko, L. This application was filed on 27-03-2019 as a Alameda, CA California 94502 (US) divisional application to the application mentioned under INID code 62. (54) FOOD OR BEVERAGE PRODUCT, OR PROBIOTIC COMPOSITION, COMPRISING LACTOBACILLUS JOHNSONII 456 (57) The present invention relates to food products, beverage products and probiotic compositions comprising Lacto- bacillus johnsonii 456. EP 3 536 328 A1 Printed by Jouve, 75001 PARIS (FR) EP 3 536 328 A1 Description CROSS-REFERENCE TO RELATED APPLICATIONS 5 [0001] This application claims the benefit of U.S. -
Genomics of Helicobacter Species 91
Genomics of Helicobacter Species 91 6 Genomics of Helicobacter Species Zhongming Ge and David B. Schauer Summary Helicobacter pylori was the first bacterial species to have the genome of two independent strains completely sequenced. Infection with this pathogen, which may be the most frequent bacterial infec- tion of humanity, causes peptic ulcer disease and gastric cancer. Other Helicobacter species are emerging as causes of infection, inflammation, and cancer in the intestine, liver, and biliary tract, although the true prevalence of these enterohepatic Helicobacter species in humans is not yet known. The murine pathogen Helicobacter hepaticus was the first enterohepatic Helicobacter species to have its genome completely sequenced. Here, we consider functional genomics of the genus Helico- bacter, the comparative genomics of the genus Helicobacter, and the related genera Campylobacter and Wolinella. Key Words: Cytotoxin-associated gene; H-Proteobacteria; gastric cancer; genomic evolution; genomic island; hepatobiliary; peptic ulcer disease; type IV secretion system. 1. Introduction The genus Helicobacter belongs to the family Helicobacteriaceae, order Campylo- bacterales, and class H-Proteobacteria, which is also known as the H subdivision of the phylum Proteobacteria. The H-Proteobacteria comprise of a relatively small and recently recognized line of descent within this extremely large and phenotypically diverse phy- lum. Other genera that colonize and/or infect humans and animals include Campylobac- ter, Arcobacter, and Wolinella. These organisms are all microaerophilic, chemoorgano- trophic, nonsaccharolytic, spiral shaped or curved, and motile with a corkscrew-like motion by means of polar flagella. Increasingly, free living H-Proteobacteria are being recognized in a wide range of environmental niches, including seawater, marine sedi- ments, deep-sea hydrothermal vents, and even as symbionts of shrimp and tubeworms in these environments. -
Enterohepatic Lesions in SCID Mice Infected with Helicobacter Bilis
Laboratory Animal Science Vol 48, No 4 Copyright 1998 August 1998 by the American Association for Laboratory Animal Science Enterohepatic Lesions in SCID Mice Infected with Helicobacter bilis Craig L. Franklin, Lela K. Riley, Robert S. Livingston, Catherine S. Beckwith, Cynthia L. Besch-Williford, and Reuel R. Hook, Jr. Abstract _ Helicobacter bilis is a recently identified species that colonizes the intestine and liver of mice. In immunocompetent mice, infections have been associated with mild hepatitis, and in immunocompromised mice, inflammatory bowel disease has been induced by intraperitoneal inoculation of the organism. We re- port inoculation of 6-week-old C.B-17 scid/scid mice by gastric gavage with approximately 107 H. bilis colony- forming units. Groups of mice were euthanized and necropsied 12, 24, and 36 weeks after inoculation. Mild to moderate proliferative typhlitis was evident in all mice at 12 and 36 weeks after inoculation and in most mice 24 weeks after inoculation. Mild to severe chronic active hepatitis was detected in 10 of 10 male mice and 3 of 10 female mice. These results indicate that H. bilis can cause moderate to severe enterohepatic disease in immunocompromised mice. The genus Helicobacter is a rapidly expanding genus volved in lesion development. Culture of specimens from currently containing 17 named species. Members of this mice confirmed intestinal colonization with H. hepaticus. Fox genus are microaerophilic, have curved to spiral rod mor- et al. reported enteric lesions in immunocompetent germ- phology, and are motile by flagella that vary in number free Swiss Webster mice infected with H. hepaticus (15), and and location among various species (1). -
Development of a Gut Microbiota Diagnostic Tool for Pediatric Inflammatory Bowel Disease Based on GA-Maptm Technology Platform
Development of a gut microbiota diagnostic tool for pediatric inflammatory bowel disease based on GA-mapTM technology platform DINA LILLESETH VANGEN Norwegian University of Life Science Department of Chemistry, Biotechnology and Food Science Master Thesis 2011/2012 ! ""! ! ABSTRACT Inflammatory bowel disease (IBD) is an idiopathic, severe disease, which is characterized by chronic inflammation of the gastrointestinal tract. The incidence of IBD has increased through the last decades and specially among the pediatric population. The time from onset of symptoms to a final diagnose is made, is often related to delays and for many patients it is an emotionally demanding process. Early investigation in suspected cases may reduce the delay so that a treatment can begin as soon as possible. The involvement of intestinal microflora for pathogenesis of IBD is a link to further investigations to understand the disease, and to help people who suffer from IBD. The aim of the present work was to distinguish between pediatric IBD and non-IBD by identifying signatures in the microbiota. This was accomplished by use of a diagnostic tool based on GA-mapTM technology and the use of single nucleotide primer extension (SNuPE) probes to search for complementary bacterial 16S rRNA gene sequences. Seventy-four feces samples were collected from cohort and tested against 77 SNuPE probes. Statistical analysis was performed with Partial Least Squares – Discriminant Analysis and presented specificity by 82 % and sensitivity by 86 %. Classification error presented 16 % and indicated how many that was misclassified by the model. Inflammatory bowel disease is considered to include two major disorders where Crohn’s disease is one of them, and best correlation was found between Crohn’s disease and non-IBD through statistical analysis. -
COMICR-D-15-00068R1 Title
Elsevier Editorial System(tm) for Current Opinion in Microbiology Manuscript Draft Manuscript Number: COMICR-D-15-00068R1 Title: Motility in the epsilon-proteobacteria Article Type: SI: 28 Growth&Devel:Eukar/Prokar 2015 Corresponding Author: Dr. Morgan Beeby, Corresponding Author's Institution: Imperial College London First Author: Morgan Beeby Order of Authors: Morgan Beeby Abstract: The epsilon-proteobacteria are a widespread group of flagellated bacteria frequently associated with either animal digestive tracts or hydrothermal vents, with well-studied examples in the human pathogens of Helicobacter and Campylobacter genera. Flagellated motility is important to both pathogens and hydrothermal vent members, and a number of curious differences between the epsilon-proteobacterial and enteric bacterial motility paradigms make them worthy of further study. The epsilon-proteobacteria have evolved to swim at high speed and through viscous media that immobilize enterics, a phenotype that may be accounted for by the molecular architecture of the unusually large epsilon- proteobacterial flagellar motor. This review summarizes what is known about epsilon-proteobacterial motility and focuses on a number of recent discoveries that rationalize the differences with enteric flagellar motility. *Manuscript Click here to view linked References 1 Motility in the epsilon-proteobacteria 2 3 Morgan Beebya, * 4 5 aDepartment of Life Sciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK. 6 *Corresponding author: MB: email: [email protected]. Telephone: +44 (0) 20 7594 5251, Fax: +44 7 (0)20 7594 3057 8 Abstract 9 The epsilon-proteobacteriaare a widespread group of flagellated bacteria frequently associated with either 10 animal digestive tracts or hydrothermal vents, with well-studied examples in the human pathogens of 11 Helicobacter and Campylobacter genera. -
CHRO Guidebook
Downloaded from orbit.dtu.dk on: Oct 07, 2021 A viable quantitative approach (v-qPCR) for detecting Arcobacter species Salas-Masso, N.; Than Linh, Quyen; Chin, Wai Hoe; Wolff, Anders; Andree, K. B.; Furones, M. D.; Figueras, M. D.; Bang, Dang Duong Published in: Proceedings of the 18th International workshop on Campylobacter, Helicobacter & Related Organisms - CHRO 2015 Publication date: 2015 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Salas-Masso, N., Than Linh, Q., Chin, W. H., Wolff, A., Andree, K. B., Furones, M. D., Figueras, M. D., & Bang, D. D. (2015). A viable quantitative approach (v-qPCR) for detecting Arcobacter species. In Proceedings of the 18th International workshop on Campylobacter, Helicobacter & Related Organisms - CHRO 2015: Delegate Handbook (pp. 65-65). [0067]. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and -
MESTRADO INTEGRADO EM MEDICINA DENTÁRIA Dissertação
MESTRADO INTEGRADO EM MEDICINA DENTÁRIA BIOLOGIA COMPUTACIONAL CRIAÇÃO DA BASE DE DADOS ORALM ASSOCIADA À BASE ORALOME Dissertação apresentada à Universidade Católica Portuguesa para obtenção do grau de Mestre em Medicina Dentária Por: Carlos Eduardo Nogueira de Sá Viseu, 2014 MESTRADO INTEGRADO EM MEDICINA DENTÁRIA BIOLOGIA COMPUTACIONAL CRIAÇÃO DA BASE DE DADOS ORALM ASSOCIADA À BASE ORALOME Dissertação apresentada à Universidade Católica Portuguesa para obtenção do grau de Mestre em Medicina Dentária Orientador: Professora Doutora Maria José Correia Co-orientador: Professor Doutor Joel Arrais Por: Carlos Eduardo Nogueira de Sá Viseu, 2014 “Learn the rules like a pro, so you can break them like an artist.” Pablo Picasso I Dedicada aos meus pais, António e Maria Helena, por todo o amor e por todos os valores que me incutiram ao longo da vida, à confiança e liberdade depositada que me permitiram desenvolver espírito crítico para olhar o mundo com os meus próprios olhos! III Agradecimentos À Professora Doutora Maria José Correia, Manifesto a minha maior gratidão pela orientação e disponibilidade ao longo de todo o trabalho e por toda a sabedoria e simpatia disponibilizada ao longo de todo o meu percurso académico. Ao Professor Doutor Joel Arrais, Pela co-orientação disponibilizada que permitiu a realização deste trabalho. À Professora Doutora Marlene Barros e ao Professor Doutor Nuno Rosa, Pela disponibilidade e agilidade em ensinar e ajudar a ultrapassar os obstáculos. À Professora Doutora Filomena Capucho, Pela oportunidade e acompanhamento da minha experiência Erasmus, que me permitiu desenvolver capacidades e acima de tudo crescer como pessoa. Aos meus pais, Por tudo. -
2019 AAVLD Proceedings
Cover art created with Fotosketcher IFC leave blank AAVLD Strategic Plan Updated August 7, 2019 Vision The AAVLD is a world leader in advancing the discipline of veterinary diagnostic laboratory science to promote global animal health and One Health. Mission The AAVLD promotes continuous improvement and public awareness of veterinary diagnostic laboratories by advancing the discipline of veterinary diagnostic laboratory science. The AAVLD provides avenues for education, communication, peer-reviewed publication, collaboration, outreach, and laboratory accreditation. Motto: Advancing veterinary diagnostic laboratory science Core values The AAVLD is committed to these core values: • Continuous improvement • Engagement of members • Effective communication • Collaboration • Support of One Health Goals 1. Advocate for the role of veterinary diagnostic laboratories in One Health by engaging in development of animal health initiatives, policies, and dissemination of surveillance information. 2. Foster continuous improvement of diagnostic laboratories through accreditation and continuing education activities while encouraging discovery and innovation in veterinary laboratory diagnostic sciences. 3. Strengthen communication with members and promote their continued professional growth. Our membership spans more than 32 countries worldwide. Join us today and discover for yourself the benefits and resources that AAVLD provides to its members. https://www.aavld.org https://www.facebook.com/AAVLD American Association of Veterinary Laboratory Diagnosticians The American Association of Veterinary Laboratory Diagnosticians (AAVLD) is a not-for-profit professional organization. AAVLD Officers, 2019 President Keith Bailey, Stillwater, OK President-elect Deepanker Tewari, Harrisburg, PA Vice-president Shuping Zhang, Columbia, MO Secretary-Treasurer Kristy Pabilonia, Fort Collins, CO Immediate Past-President Steve Hooser, West Lafayette, IN AAVLD Executive Director David H. -
Role of Campylobacter Jejuni Gamma-Glutamyl Transpeptidase On
Floch et al. Gut Pathogens 2014, 6:20 http://www.gutpathogens.com/content/6/1/20 RESEARCH Open Access Role of Campylobacter jejuni gamma-glutamyl transpeptidase on epithelial cell apoptosis and lymphocyte proliferation Pauline Floch1,2, Vincent Pey1,2, Michel Castroviejo3, Jean William Dupuy4, Marc Bonneu4, Anaïs Hocès de la Guardia1,2, Vincent Pitard5, Francis Mégraud1,2 and Philippe Lehours1,2,6* Abstract Background: A gamma-glutamyl transpeptidase (GGT) is produced by up to 31% of strains of Campylobacter jejuni isolates. C. jejuni GGT is close to Helicobacter pylori GGT suggesting a conserved activity but unlike the latter, C. jejuni GGT has not been studied extensively. In line with the data available for H. pylori, our objectives were to purify C. jejuni GGT from the bacteria, and to evaluate its inhibitory and proapoptotic activities on epithelial cells and human lymphocytes. Methods: C. jejuni GGT was purified from culture supernatants by chromatography. After verification of the purity by using mass spectrometry of the purified enzyme, its action on two epithelial cell lines and human lymphocytes was investigated. Cell culture as well as flow cytometry experiments were developed for these purposes. Results: This study demonstrated that C. jejuni GGT is related to Helicobacter GGTs and inhibits the proliferation of epithelial cells with no proapoptotic activity. C. jejuni GGT also inhibits lymphocyte proliferation by causing a cell cycle arrest in the G0/G1 phase. These effects are abolished in the presence of a specific pharmacological inhibitor of GGT. Conclusion: C. jejuni GGT activity is comparable to that of other Epsilonproteobacteria GGTs and more generally to Helicobacter bilis (inhibition of epithelial cell and lymphocyte proliferation, however with no proapoptotic activity). -
Title: Bartonella Dynamics in Indigenous
Molecular diversity and prevalence of Helicobacter, Bartonella and Streptococcus in Mus musculus from sub-Antarctic Marion Island in relation to host diversity By Candice Eadie Submitted in partial fulfillment of the requirements for the degree Master of Science (Zoology) Faculty of Natural and Agricultural Sciences Department of Zoology and Entomology University of Pretoria Pretoria South Africa Supervisors: Prof A.D.S. Bastos, Prof M.N. Bester and Prof S.N. Venter December 2011 1 © University of Pretoria Declaration I, Candice Eadie hereby declare that the dissertation, which I hereby submit for the degree Master of Science (Zoology) at the University of Pretoria, is my own work and has not previously been submitted by me for a degree at this or any other tertiary institution. Signature: Date : 9/12/2011 2 Disclaimer This thesis consists of a series of chapters that have been prepared as stand-alone manuscripts for subsequent submission for publication purposes. Consequently, unavoidable overlaps and/or repetitions may occur between chapters. 3 Molecular diversity and prevalence of Helicobacter, Bartonella and Streptococcus in Mus musculus from sub-Antarctic Marion Island in relation to host diversity by Candice Eadie Mammal Research Institute (MRI), Department of Zoology and Entomology, University of Pretoria, Private Bag X20, Hatfield, 0028 South Africa SUPERVISORS: Prof. A.D.S. Bastos Mammal Research Institute (MRI), Department of Zoology and Entomology, University of Pretoria, Private Bag X20, Hatfield, 0028 South Africa Prof. M.N. Bester Mammal Research Institute (MRI), Department of Zoology and Entomology, University of Pretoria, Private Bag X20, Hatfield, 0028 South Africa. Prof. S.N. Venter Department of Microbiology and Plant pathology, University of Pretoria, Private Bag X20, Hatfield, 0028 South Africa. -
Xenobiotics: Interaction with the Intestinal Microflora
ILAR Journal, 2015, Vol. 56, No. 2, 218–227 doi: 10.1093/ilar/ilv018 Article Xenobiotics: Interaction with the Intestinal Microflora Kun Lu, Ridwan Mahbub, and James G. Fox Downloaded from Kun Lu, PhD, is an Assistant Professor in the Department of Environmental Health Science at the University of Georgia, Athens, Georgia. Ridwan Mahbub, BSA, MS, was a graduate student in the laboratory of Dr. Kun Lu at University of Georgia, Athens, Georgia. James G. Fox, DVM, is currently Professor and Director of the Division of Comparative Medicine at the Massachusetts Institute of Technology, Cambridge, Massachusetts. http://ilarjournal.oxfordjournals.org/ Address correspondence and reprint requests to Dr. Kun Lu, 140 Environmental Health Science Building, University of Georgia, Athens, GA 30602 or email [email protected]. Abstract The human body is host to 100 trillion gut microbes, approximately 10-times more than all human cells. It is estimated that the approximately 500–1000 species residing in the human gut encode 150-fold more unique genes than the human genome. The gut microbiota has important functions in metabolic processing, such as energy production, immune cell development, food digestion, and epithelial homeostasis. It has been increasingly recognized that a dysregulated gut microbiome contributes in asignificant way to a variety of diseases, including diabetes, obesity, cardiovascular diseases, allergies, and inflammatory at King's College London on December 19, 2015 bowel disease. In particular, accumulating evidence indicates that functional interactions between the gut microbiome and xenobiotics play a role in mediating chemical toxicity and causing or exacerbating human disease. This review summarizes emerging evidence that illustrates how xenobiotics can affect the gut microbiome structure, create functional changes to the gut microbiome, and become biotransformed by the gut microbiome. -
Framework for the Development Of
Standards for Pathology Informatics in Australia (SPIA) Reporting Terminology and Codes Microbiology (v3.0) Superseding and incorporating the Australian Pathology Units and Terminology Standards and Guidelines (APUTS) ISBN: Pending State Health Publication Number (SHPN): Pending Online copyright © RCPA 2017 This work (Standards and Guidelines) is copyright. You may download, display, print and reproduce the Standards and Guidelines for your personal, non- commercial use or use within your organisation subject to the following terms and conditions: 1. The Standards and Guidelines may not be copied, reproduced, communicated or displayed, in whole or in part, for profit or commercial gain. 2. Any copy, reproduction or communication must include this RCPA copyright notice in full. 3. No changes may be made to the wording of the Standards and Guidelines including commentary, tables or diagrams. Excerpts from the Standards and Guidelines may be used. References and acknowledgments must be maintained in any reproduction or copy in full or part of the Standards and Guidelines. Apart from any use as permitted under the Copyright Act 1968 or as set out above, all other rights are reserved. Requests and inquiries concerning reproduction and rights should be addressed to RCPA, 207 Albion St, Surry Hills, NSW 2010, Australia. This material contains content from LOINC® (http://loinc.org). The LOINC table, LOINC codes, LOINC panels and forms file, LOINC linguistic variants file, LOINC/RSNA Radiology Playbook, and LOINC/IEEE Medical Device Code Mapping Table are copyright © 1995-2016, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/terms-of-use.” This material includes SNOMED Clinical Terms® (SNOMED CT®) which is used by permission of the International Health Terminology Standards Development Organisation (IHTSDO®).