Guide for the Selection of Chemical Agent and Toxic Industrial Material Detection Equipment for Emergency First Responders
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Fluoride (Developmental Neurotoxicity and Endocrine Disruption)
Bill Osmunson DDS, MPH November 6, 2015 [email protected] Dr. Kristina Thayer Director, Office of Health Assessment and Translation National Toxicology Program Email: [email protected] (1) DATA ON CURRENT PRODUCTION, USE PATTERNS, AND HUMAN EXPOSURE A. The FDA approved fluoride toothpaste caution, “Do Not Swallow.” No safe dosage or amount is stated. “Do Not Swallow” is simple to understand. Use a pea or smear size and if more than used for brushing is swallowed, contact the poison control center. A quarter milligram of fluoride is in a pea size of fluoride toothpaste, the same amount found in each 11 oz glass of 0.7 ppm fluoridated public water. Fluoridated water is dispensed to everyone without regards for other fluoride exposures, individual consent, health, or sensitivity. The only safe amount of fluoride is, “Do Not Swallow.” Swallowing fluoride is not safe, however, many children swallow their toothpaste due to taste and the swallow reflex is part of the spitting action. B. Fluoridated water is the primary source of fluoride for many people. Fluoridated toothpaste is considered the second primary source and for some is more than fluoridated water. Other significant sources of fluoride include bone meal, mechanically deboned meat, grape products with cryolite, several legend drugs and sulfuryl fluoride, a post harvest fumigant. C. The FDA sent a letter to about 35 fluoride supplement manufacturers, “. there is no substantial evidence of drug effectiveness as prescribed, recommended or suggested in its labeling. .” (Drug Therapy -
Phosphorus Oxychloride CAS No
Product Safety Summary Phosphorus Oxychloride CAS No. 10025-87-3 This Product Safety Summary is intended to provide a general overview of the chemical substance. The information in the summary is basic information and is not intended to provide emergency response information, medical information or treatment information. The summary should not be used to provide in-depth safety and health information. In-depth safety and health information can be found in the Safety Data Sheet (SDS) for the chemical substance. Names Phosphorus oxychloride Phosphorus trichloride oxide Phosphoric trichloride POCl 3 Product Overview Solvay Novecare does not sell phosphorus oxychloride directly to consumers. Phosphorus oxychloride (POCl3) is used as a chemical intermediate to produce a variety of products which are used in several applications including manufacture of triarylphosphate esters which are used as flame retardants as well as an intermediate in the production of pharmaceutical, textile and agricultural chemicals. Phosphorus oxychloride is used in industrial applications and other processes where workplace exposures can occur. Consumer exposure does not occur as phosphorus oxychloride is not used in any commercially available product. Phosphorus oxychloride is dangerous to human health. Phosphorus oxychloride may be fatal if inhaled, highly toxic if swallowed, harmful if absorbed through skin and can cause severe burns which may result in scarring. Phosphorus oxychloride is consumed in manufacturing processes. POCl3 can make its way into the environment through unintentional releases (spills). POCl3 will not bioaccumulate but is not biodegradable. POCl3 in higher concentrations can be harmful to aquatic life due to formation of acids from the hydrolysis of POCl3. When released into the atmosphere, phosphorus oxychloride exists as vapor. -
Residual Fluoride in Food Fumigated with Sulfuryl Fluoride
Fluoride 2005;38(3):175–177 Editorial 175 RESIDUAL FLUORIDE IN FOOD FUMIGATED WITH SULFURYL FLUORIDE SUMMARY: New US federal allowances for inorganic fluoride residues in food fumigated with sulfuryl fluoride are excessively high and are at levels known to cause serious adverse health effects, including crippling skeletal fluorosis. Fluoride in food has long been recognized as a potential source of adverse health effects including dental fluorosis, bone and joint defects, gastrointestinal disturbances, and muscular-neurological disorders,1-2 plus even crippling skeletal fluorosis.3 In China, food contaminated by fluoride (F) from unvented coal burning used to dry and preserve grains and other crops is an important source of F intake,4 and F levels from such exposure ranging from 18 to 87 ppm in corn and 114 to 1109 ppm in chili have been reported.5 In these coal-burning F-endemic areas, even with very little F in the drinking water, the total daily F intake by affected adults has been estimated to be between 6.12 and 9.65 mg, with the major contribution coming from food.5 By contrast, in non-endemic areas, daily F intake was estimated to be only 0.8 mg/day.5 Therefore, any appreciable increase in F intake resulting from commercial food fumigation procedures can only be viewed with grave concern. In place of methyl bromide as an insecticide fumigant because of its upper atmosphere ozone depleting ability, a number of substitutes are already in use with varying results. For example, various combinations of phosphine (PH3) and carbon dioxide have been fairly successful for food as well as general fumigation, although equipment corrosion from phosphine and insect resistance to it are among its drawbacks. -
Downloads/DL Praevention/Fachwissen/Gefahrstoffe/TOXIKOLOGI SCHE BEWERTUNGEN/Bewertungen/Toxbew072-L.Pdf
Distribution Agreement In presenting this thesis or dissertation as a partial fulfillment of the requirements for an advanced degree from Emory University, I hereby grant to Emory University and its agents the non-exclusive license to archive, make accessible, and display my thesis or dissertation in whole or in part in all forms of media, now or hereafter known, including display on the world wide web. I understand that I may select some access restrictions as part of the online submission of this thesis or dissertation. I retain all ownership rights to the copyright of the thesis or dissertation. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation. Signature: _____________________________ ______________ Jedidiah Samuel Snyder Date Statistical analysis of concentration-time extrapolation factors for acute inhalation exposures to hazardous substances By Jedidiah S. Snyder Master of Public Health Global Environmental Health _________________________________________ P. Barry Ryan, Ph.D. Committee Chair _________________________________________ Eugene Demchuk, Ph.D. Committee Member _________________________________________ Paige Tolbert, Ph.D. Committee Member Statistical analysis of concentration-time extrapolation factors for acute inhalation exposures to hazardous substances By Jedidiah S. Snyder Bachelor of Science in Engineering, B.S.E. The University of Iowa 2010 Thesis Committee Chair: P. Barry Ryan, Ph.D. An abstract of A thesis submitted to the Faculty of the Rollins School of Public Health of Emory University in partial fulfillment of the requirements for the degree of Master of Public Health in Global Environmental Health 2015 Abstract Statistical analysis of concentration-time extrapolation factors for acute inhalation exposures to hazardous substances By Jedidiah S. -
5 Phosphorus Oxychloride1 Acute Exposure Guideline Levels
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 Committee on Acute Exposure Guideline Levels Committee on Toxicology Board on Environmental Studies and Toxicology Division on Earth and Life Studies Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 10 THE NATIONAL ACADEMIES PRESS 500 FIFTH STREET, NW WASHINGTON, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Insti- tute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This project was supported by Contract No. W81K04-06-D-0023 and EP-W-09-007 be- tween the National Academy of Sciences and the U.S. Department of Defense and the U.S. Environmental Protection Agency. Any opinions, findings, conclusions, or recom- mendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project. International Standard Book Number-13: 978-0-309-21987-7 International Standard Book Number-10: 0-309-21987-6 Additional copies of this report are available from The National Academies Press 500 Fifth Street, NW Box 285 Washington, DC 20055 800-624-6242 202-334-3313 (in the Washington metropolitan area) http://www.nap.edu Copyright 2011 by the National Academy of Sciences. -
( 12 ) United States Patent
US009853326B2 (12 ) United States Patent ( 10 ) Patent No. : US 9 ,853 , 326 B2 Tokuda et al. ( 45 ) Date of Patent: Dec. 26 , 2017 ( 54 ) NONAQUEOUS ELECTROLYTE FOR (58 ) Field of Classification Search SECONDARY BATTERY AND CPC .. .. HO1M 10 /0569 ; HOTM 10 /0567 ; HOLM NONAQUEOUS - ELECTROLYTE 10 /0525 ; HOTM 4 /587 ; HOTM 4 / 134 ; SECONDARY BATTERY EMPLOYING THE HO1M 2300 /0025 ; YO2E 60 / 122 SAME See application file for complete search history . References Cited ( 71 ) Applicant: MITSUBISHI CHEMICAL (56 ) CORPORATION , Chiyoda- ku ( JP ) U . S . PATENT DOCUMENTS 5 ,580 ,684 A 12 / 1996 Yokoyama et al . (72 ) Inventors : Hiroyuki Tokuda, Ibaraki ( JP ) ; 5 , 754 , 393 A 5 / 1998 Hiratsuka et al. Minoru Kotato , Ibaraki ( JP ) ; Masahiro 6 ,001 , 325 A 12 / 1999 Salmon et al. Takehara , Ibaraki ( JP ) ; Shinichi 6 ,033 , 808 A 3 / 2000 Salmon et al. Kinoshita , Ibaraki ( JP ) 6 , 436, 582 B1 8 / 2002 Hamamoto et al. 6 , 919, 145 B1 7 / 2005 Kotato et al . 2001/ 0044051 AL 11/ 2001 Hamamoto et al. ( 73 ) Assignee : MITSUBISHI CHEMICAL 2002 / 0192564 Al 12 /2002 Ota et al. CORPORATION , Chiyoda -ku ( JP ) 2004 / 0048164 Al 3 /2004 Jung et al . 2004 / 0091786 A1 5 / 2004 Unoki et al. 2004 / 0191636 A1 9 / 2004 Kida et al . ( * ) Notice: Subject to any disclaimer , the term of this 2005 / 0008939 A1 1 / 2005 Ota et al. patent is extended or adjusted under 35 2005 /0014071 A1 1 / 2005 Noda et al. U . S . C . 154 ( b ) by 412 days. 2005 / 0084765 A1 4 / 2005 Lee et al . 2005 / 0118512 Al 6 / 2005 Onuki et al . -
Medicine with Deeper, More Biochemical Conception Of
Edinburgh Medical Journal May 1951 APPLICATIONS of chemical defence research IN MEDICINET? By Professor R. A. PETERS to be invited It is a great responsibility, as well as a great honour, to Cameron lecturers give this lecture ; and I expect that with other I this ancient seat of share a sense of awe upon standing here in is learning. For me it is an awe tinged with much feeling (it possible that this is partly because some forebears of my mother came from near to recent of the this ; it is in part due the perusal city) perhaps " address here Froude in on the Times of John Knox, given by 1865 " " entitled Influence of the Reformation upon the Scottish Character ; this address drives home to the Sassenach the sterner stuff of which all of us in the the Scots are made ; but I really think it is more that as south, even if we come as I do from a Medical School as ancient the Hospital of St Bartholomew, know full well that Edinburgh stands high indeed in the world of Medical Schools as Scotland itself stands in the world of intellect. Elsewhere I have discussed fully the historical background of our for me back researches upon Chemical Defence substances, which go to World War I.23 Again in my Dixon lecture,24 I have indicated some of the interest for pharmacology. The outlook for medicine has not the been reviewed so far. Therefore I propose to-day to discuss of British influence upon the future of therapeutics of the discovery anti-lewisite and of some of the other researches upon war gas but substances ; and to consider not only the leads towards therapy, the possible newer trends given to medicine itself. -
2018 Annual Survey of Biological and Chemical Agents Regulated by Homeland Security (And Carcinogens Regulated by OSHA)
Name: Dept: Date: 2018 Annual Survey of Biological and Chemical Agents regulated by Homeland Security (and carcinogens regulated by OSHA) Due (date) All labs that do not have a current chemical inventory in Chematix MUST complete this survey. The University is required to make an annual report of all chemicals on the Chemical Facility Anti-Terrorism Standards (CFATS) lists. Additional information regarding the regulations is available on the EH&S website at http://www.safety.rochester.edu/restricted/occsafe/chemicalagent.html and https://www.selectagents.gov. 1. Please review the lists on the following pages and indicate if any are possessed by your lab. The CAS# has been added to the list for ease of searching databases. The CAS# is a Chemical Abstract Service numbering system which assigns a unique number to every chemical substance based on structure; this helps avoid confusion by use of synonyms or different naming conventions. a. If yes for possession, place an X in the applicable box and if requested, include the quantity held in your lab. b. If no, leave blank. 2. After reviewing the list, please complete the information box below (or on last page for possession), then sign, date and return to EH&S. 3. Please call Donna Douglass at 275-2402 if you have any questions. Thank you for your cooperation in collecting data required by the Department of Homeland Security! Possession: 1) Fill in applicable boxes, 2) have PI sign last page, 3) return all pages to Donna Douglass OR Non-possession: 1) Check only one box on the left, 2) sign, 3) return just this page to Donna Douglass I do not have a lab, do not work in a lab, nor do I possess any of the agents in this survey. -
SAPRC07T Mechanism Species Definition Molecular Weight ACETONE Acetone 58.08 ACETYLENE Acetylene 26.04 ACROLEIN Acrolein 56.06 A
SAPRC07T Mechanism Species Molecular Species Definition weight ACETONE Acetone 58.08 ACETYLENE Acetylene 26.04 ACROLEIN Acrolein 56.06 ACROLEIN_PRIMARY Acrolein emissions tracer 56.06 Lumped photoreactive monounsaturated dicarbonyl aromatic AFG1 fragmentation products that photolyze to form radicals 98.10 Lumped photoreactive monounsaturated dicarbonyl aromatic fragmentation products that photolyze to form non-radical AFG2 products 98.10 Lumped diunsaturatred dicarbonyl aromatic fragmentation AFG3 product. 124.14 Alkanes and other non-aromatic compounds that react only with OH, and have kOH between 2 and 5 x 102 ppm-1 min-1. ALK1 (Primarily ethane) 30.07 Alkanes and other non-aromatic compounds that react only with OH, and have kOH between 5 x 102 and 2.5 x 103 ppm-1 ALK2 min-1. (Primarily propane and acetylene) 36.73 Alkanes and other non-aromatic compounds that react only with OH, and have kOH between 2.5 x 103 and 5 x 103 ppm-1 ALK3 min-1. 58.61 Alkanes and other non-aromatic compounds that react only with OH, and have kOH between 5 x 103 and 1 x 104 ppm-1 ALK4 min-1. 77.6 Alkanes and other non-aromatic compounds that react only ALK5 with OH, and have kOH greater than 1 x 104 ppm-1 min-1. 118.89 SAPRC07T Mechanism Species Molecular Species Definition weight SOA precursor compounds products from largest alkanes ALK5RXN (ALK5) 118.9 APIN -pinene 136.23 ARO1 Aromatics with kOH < 2x104 ppm-1 min-1. 95.16 ARO2 Aromatics with kOH > 2x104 ppm-1 min-1. 118.72 BACL Biacetyl 86.09 BALD Aromatic aldehydes (e.g., benzaldehyde) 106.13 BENZENE Benzene 78.11 SOA precursor compounds from benzene via peroxy radical BNZHRXN reaction with HO2 127 SOA precursor compounds from benzene via peroxy radical BNZNRXN reaction with NO 127 BNZRO2 SOA precursor surrogate from benzene 127 BUTADIENE13 1,3-butadiene 54.09 BZCO3 Peroxyacyl radical formed from Aromatic Aldehydes 137.11 BZO Phenoxy Radicals 93 CCHO Acetaldehyde 44.05 CCHO_PRIMARY Acetaldehyde Emissions Tracer 44.05 CCOOH Acetic Acid. -
Assessment of Portable HAZMAT Sensors for First Responders
The author(s) shown below used Federal funds provided by the U.S. Department of Justice and prepared the following final report: Document Title: Assessment of Portable HAZMAT Sensors for First Responders Author(s): Chad Huffman, Ph.D., Lars Ericson, Ph.D. Document No.: 246708 Date Received: May 2014 Award Number: 2010-IJ-CX-K024 This report has not been published by the U.S. Department of Justice. To provide better customer service, NCJRS has made this Federally- funded grant report available electronically. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. Department of Justice. Assessment of Portable HAZMAT Sensors for First Responders DOJ Office of Justice Programs National Institute of Justice Sensor, Surveillance, and Biometric Technologies (SSBT) Center of Excellence (CoE) March 1, 2012 Submitted by ManTech Advanced Systems International 1000 Technology Drive, Suite 3310 Fairmont, West Virginia 26554 Telephone: (304) 368-4120 Fax: (304) 366-8096 Dr. Chad Huffman, Senior Scientist Dr. Lars Ericson, Director UNCLASSIFIED This project was supported by Award No. 2010-IJ-CX-K024, awarded by the National Institute of Justice, Office of Justice Programs, U.S. Department of Justice. The opinions, findings, and conclusions or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect those of the Department of Justice. This document is a research report submitted to the U.S. Department of Justice. This report has not been published by the Department. Opinions or points of view expressed are those of the author(s) and do not necessarily reflect the official position or policies of the U.S. -
NPR72: the Pavlodar Chemical Weapons Plant in Kazakhstan
GULBARSHYN BOZHEYEVA Report The Pavlodar Chemical Weapons Plant in Kazakhstan: History and Legacy GULBARSHYN BOZHEYEVA Gulbarshyn Bozheyeva holds a Ph.D. degree in Chemical Physics from the Kazakh State University. From 1996-97, she was a Visiting Scholar and Research Associate at the Center for Nonproliferation Studies at the Monterey Institute of International Studies. She is now completing a master’s degree in International Development Policy at Duke University. he former Soviet Union’s chemical weapons theless, manufacturing lines and equipment for primary (CW) program consisted of many production and intermediate CW precursors and buildings for fill- plants that created the world’s largest stockpile ing CW munitions were constructed at Pavlodar. The T 1 of chemical weapons. Most of the CW production and plant also acquired personnel with expertise in CW pro- storage facilities were located in Russia, but a few fa- duction.5 cilities existed in other Soviet republics. In recent years, This report is devoted to the role of the Pavlodar Western countries have provided significant financial Chemical Plant in the former Soviet CW program and assistance for dismantling former CW facilities in Rus- its current status. The first part of the report describes sia and converting former CW production facilities for the history of the Pavlodar plant and its military and 2 commercial use. Although a fair amount has been writ- civilian infrastructures. The second part deals with the ten about Russian CW facilities, little is known about CW capability of the plant and the nature of the chemi- the CW programs in other former Soviet republics. -
Decision-Making in Chemical Warfare Agent (CWA) Response There Is a Lot of Fear Associated with Chemical Will Act Accordingly
Application Note: 102 Decision-Making in Chemical Warfare Agent (CWA) Response There is a lot of fear associated with Chemical will act accordingly. If the first responders Warfare Agents (CWAs). The misnomer over-react and immediately jump into full “Nerve Gas” quickly brings horrible images to encapsulation protection it could panic the the minds of many civilians. But if we lay aside public and cause unnecessary worry and the politics and fear, CWA detection should even injury. treated like other gas/vapor detection challenges. It should be a collaborative Over Protection Can Be Dangerous process encompassing physical clues, threat to the Responder scenario, biological clues, and a variety of Heat stress is the number one injury in sensing technologies. No one clue or HazMat response and immediately jumping technology is always correct. Experience and into full Level A encapsulation is a good way the use of multiple clues and technologies are of overheating oneself. Level A the keys to successful CWA response. encapsulation also makes one much more Understanding what the clues are and how to susceptible to slip, trip and fall injuries. layer them to make a decision is critical to Finally, over protection makes it harder to get successful CWA response. things done. When properly used, detection allows responders to respond at lower levels Why is Gas Detection Important? of Personal Protective Equipment (PPE) to Responders cannot rely on their senses for provide the highest levels of safety to decision-making. Without effectively knowing themselves and to the community that they how to use detection techniques responders protect.